FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5211, 207 aa 1>>>pF1KE5211 207 - 207 aa - 207 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0847+/-0.000334; mu= 14.7314+/- 0.021 mean_var=63.4128+/-12.829, 0's: 0 Z-trim(115.8): 24 B-trim: 468 in 1/53 Lambda= 0.161059 statistics sampled from 26506 (26530) to 26506 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.311), width: 16 Scan time: 4.390 The best scores are: opt bits E(85289) NP_003245 (OMIM: 305370) metalloproteinase inhibit ( 207) 1451 345.3 4e-95 NP_003246 (OMIM: 188825) metalloproteinase inhibit ( 220) 554 136.9 2.3e-32 NP_000353 (OMIM: 136900,188826) metalloproteinase ( 211) 528 130.9 1.5e-30 NP_003247 (OMIM: 601915) metalloproteinase inhibit ( 224) 502 124.8 1e-28 XP_016885255 (OMIM: 305370) PREDICTED: metalloprot ( 261) 297 77.3 2.6e-14 >>NP_003245 (OMIM: 305370) metalloproteinase inhibitor 1 (207 aa) initn: 1451 init1: 1451 opt: 1451 Z-score: 1828.7 bits: 345.3 E(85289): 4e-95 Smith-Waterman score: 1451; 100.0% identity (100.0% similar) in 207 aa overlap (1-207:1-207) 10 20 30 40 50 60 pF1KE5 MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 YEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 TCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEK 130 140 150 160 170 180 190 200 pF1KE5 GFQSRHLACLPREPGLCTWQSLRSQIA ::::::::::::::::::::::::::: NP_003 GFQSRHLACLPREPGLCTWQSLRSQIA 190 200 >>NP_003246 (OMIM: 188825) metalloproteinase inhibitor 2 (220 aa) initn: 547 init1: 199 opt: 554 Z-score: 701.9 bits: 136.9 E(85289): 2.3e-32 Smith-Waterman score: 554; 42.8% identity (67.7% similar) in 201 aa overlap (7-199:10-203) 10 20 30 40 50 pF1KE5 MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQ-TT :: :.::: :. :. ::.: : ::: ::::.:.::::: :. ::.. . NP_003 MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGND 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 LY----QR--YEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAG .: .: ::::. ::.:: . ::.:.:: .::: .. .:.:::: NP_003 IYGNPIKRIQYEIKQIKMFKGPE-----KDIEFIYTAPSSAVCGVSLDVGGK-KEYLIAG 70 80 90 100 110 120 130 140 150 160 pF1KE5 KLQ-DGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCL : . :: .::: :.:..::..:: .:...... : .::: : . : ::: ..: .:: NP_003 KAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCE-CKITRCPMIPCYISSPDECL 120 130 140 150 160 170 170 180 190 200 pF1KE5 WTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA : : . . . .: :.. .::. : : :.: NP_003 WMDWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP 180 190 200 210 220 >>NP_000353 (OMIM: 136900,188826) metalloproteinase inhi (211 aa) initn: 512 init1: 160 opt: 528 Z-score: 669.5 bits: 130.9 E(85289): 1.5e-30 Smith-Waterman score: 528; 38.6% identity (65.8% similar) in 202 aa overlap (1-199:1-194) 10 20 30 40 50 pF1KE5 MAPFEPLASGILLLLWLIAP--SRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLY :.:. : .:: : .. ..:::: : ::: ::::::.::::: :: :.. . NP_000 MTPWLGLI--VLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFG 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 QR-YEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLL : ::. :::.:: . .....: : ::.:: . . . ..:..:.. :: . NP_000 TLVYTIKQMKMYRGFTKM---PHVQYIHTEASESLCGL--KLEVNKYQYLLTGRVYDGKM 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 HITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQG . :.:: :..:.:.::.:.. : .::. : . : .:: . : ..:::::.: . NP_000 YTGLCNFVERWDQLTLSQRKGLNYRYHLGCN-CKIKSCYYLPCFVTSKNECLWTDMLSNF 120 130 140 150 160 170 180 190 200 pF1KE5 SEKGFQSRHLACLPREPGLCTWQSLRSQIA . :.::.: ::. .. : :.: NP_000 GYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP 180 190 200 210 >>NP_003247 (OMIM: 601915) metalloproteinase inhibitor 4 (224 aa) initn: 411 init1: 152 opt: 502 Z-score: 636.4 bits: 124.8 E(85289): 1e-28 Smith-Waterman score: 502; 37.4% identity (67.0% similar) in 206 aa overlap (6-199:7-207) 10 20 30 40 50 pF1KE5 MAPFEPLASGILLL--LWLIAP---SRACTCVPPHPQTAFCNSDLVIRAKFVGTPEV-- : : .::: : :. : ..::.:.: ::: .:.: ::::::. . : NP_003 MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA 10 20 30 40 50 60 60 70 80 90 100 pF1KE5 ----NQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLI .: . :::::. ::.:::. . :....::: :.:: . : ....:. NP_003 SADPADTEKMLRYEIKQIKMFKGFEKV---KDVQYIYTPFDSSLCGV-KLEANSQKQYLL 70 80 90 100 110 110 120 130 140 150 160 pF1KE5 AGK-LQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTH .:. :.:: . : :... ::..:::.::..... : ..: : . : ..:: ... .. NP_003 TGQVLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCG-CQITTCYTVPCTISAPNE 120 130 140 150 160 170 170 180 190 200 pF1KE5 CLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA ::::: ::. . :.:..: .:. . : :.: NP_003 CLWTDWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP 180 190 200 210 220 >>XP_016885255 (OMIM: 305370) PREDICTED: metalloproteina (261 aa) initn: 315 init1: 297 opt: 297 Z-score: 378.0 bits: 77.3 E(85289): 2.6e-14 Smith-Waterman score: 297; 100.0% identity (100.0% similar) in 43 aa overlap (110-152:104-146) 80 90 100 110 120 130 pF1KE5 DIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGF :::::::::::::::::::::::::::::: XP_016 FSLSEGRAFGSLAAQPITSCLSVPAPPFSLGKLQDGLLHITTCSFVAPWNSLSLAQRRGF 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE5 TKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTW ::::::::::::: XP_016 TKTYTVGCEECTVSAWTLTSNGRSFPGPFPKSWACFLLPLAILCPCGCSPTLRAVPDLSC 140 150 160 170 180 190 207 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 22:32:45 2016 done: Mon Nov 7 22:32:46 2016 Total Scan time: 4.390 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]