Result of FASTA (omim) for
pFN21AB8434
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8434, 138 aa
1>>>pF1KB8434 138 - 138 aa - 138 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6081+/-0.000341; mu= 9.8479+/- 0.021
mean_var=123.8027+/-25.609, 0's: 0 Z-trim(117.4): 307 B-trim: 611 in 2/54
Lambda= 0.115268
statistics sampled from 28875 (29408) to 28875 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.345), width: 16
Scan time: 4.990
The best scores are: opt bits E(85289)
NP_004927 (OMIM: 600431) cyclin-dependent kinase 4 ( 138) 905 160.9 6.2e-40
NP_000068 (OMIM: 155601,155755,600160,606719) cycl ( 156) 682 123.8 9.7e-29
NP_001182061 (OMIM: 155601,155755,600160,606719) c ( 167) 682 123.9 1e-28
XP_011515978 (OMIM: 155601,155755,600160,606719) P ( 172) 682 123.9 1e-28
XP_011515977 (OMIM: 155601,155755,600160,606719) P ( 184) 682 123.9 1.1e-28
XP_005251400 (OMIM: 155601,155755,600160,606719) P ( 105) 522 97.0 7.7e-21
XP_011515981 (OMIM: 155601,155755,600160,606719) P ( 105) 522 97.0 7.7e-21
NP_511042 (OMIM: 600431) cyclin-dependent kinase 4 ( 78) 344 67.3 5.2e-12
NP_524145 (OMIM: 600927) cyclin-dependent kinase 4 ( 166) 333 65.8 3e-11
NP_001791 (OMIM: 600927) cyclin-dependent kinase 4 ( 166) 333 65.8 3e-11
NP_001253 (OMIM: 603369) cyclin-dependent kinase 4 ( 168) 289 58.5 4.8e-09
NP_523240 (OMIM: 603369) cyclin-dependent kinase 4 ( 168) 289 58.5 4.8e-09
XP_016884079 (OMIM: 613383) PREDICTED: ankyrin rep ( 235) 216 46.5 2.7e-05
NP_620152 (OMIM: 613383) ankyrin repeat domain-con ( 300) 213 46.2 4.5e-05
XP_016884080 (OMIM: 613383) PREDICTED: ankyrin rep ( 180) 196 43.1 0.00023
XP_011515651 (OMIM: 609172) PREDICTED: protein pho ( 465) 189 42.4 0.00094
NP_001316373 (OMIM: 609172) protein phosphatase 1 ( 528) 175 40.1 0.0051
NP_001316371 (OMIM: 609172) protein phosphatase 1 ( 528) 175 40.1 0.0051
NP_116291 (OMIM: 609172) protein phosphatase 1 reg ( 528) 175 40.1 0.0051
XP_016869403 (OMIM: 609172) PREDICTED: protein pho ( 528) 175 40.1 0.0051
NP_001316372 (OMIM: 609172) protein phosphatase 1 ( 528) 175 40.1 0.0051
NP_001316374 (OMIM: 609172) protein phosphatase 1 ( 528) 175 40.1 0.0051
NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens (1166) 177 40.9 0.0068
XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 (1169) 177 40.9 0.0068
XP_016863601 (OMIM: 106410,600919) PREDICTED: anky (1689) 179 41.4 0.0069
XP_016863600 (OMIM: 106410,600919) PREDICTED: anky (1755) 179 41.4 0.007
XP_016863599 (OMIM: 106410,600919) PREDICTED: anky (1763) 179 41.4 0.0071
XP_016863598 (OMIM: 106410,600919) PREDICTED: anky (1770) 179 41.4 0.0071
XP_016863597 (OMIM: 106410,600919) PREDICTED: anky (1772) 179 41.4 0.0071
XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797) 179 41.4 0.0071
XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 179 41.4 0.0072
XP_016863594 (OMIM: 106410,600919) PREDICTED: anky (1810) 179 41.4 0.0072
XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816) 179 41.4 0.0072
XP_016863593 (OMIM: 106410,600919) PREDICTED: anky (1818) 179 41.4 0.0072
XP_016863591 (OMIM: 106410,600919) PREDICTED: anky (1838) 179 41.4 0.0072
XP_016863590 (OMIM: 106410,600919) PREDICTED: anky (1839) 179 41.4 0.0072
XP_016863589 (OMIM: 106410,600919) PREDICTED: anky (1846) 179 41.4 0.0073
XP_016863588 (OMIM: 106410,600919) PREDICTED: anky (1850) 179 41.4 0.0073
XP_016863587 (OMIM: 106410,600919) PREDICTED: anky (1851) 179 41.4 0.0073
XP_016863586 (OMIM: 106410,600919) PREDICTED: anky (1858) 179 41.4 0.0073
XP_016863585 (OMIM: 106410,600919) PREDICTED: anky (1862) 179 41.4 0.0073
NP_001120965 (OMIM: 106410,600919) ankyrin-2 isofo (1863) 179 41.4 0.0073
XP_016863583 (OMIM: 106410,600919) PREDICTED: anky (1871) 179 41.4 0.0073
XP_016863584 (OMIM: 106410,600919) PREDICTED: anky (1871) 179 41.4 0.0073
NP_066187 (OMIM: 106410,600919) ankyrin-2 isoform (1872) 179 41.5 0.0073
XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879) 179 41.5 0.0074
XP_016863582 (OMIM: 106410,600919) PREDICTED: anky (1881) 179 41.5 0.0074
XP_016863581 (OMIM: 106410,600919) PREDICTED: anky (1882) 179 41.5 0.0074
XP_016863579 (OMIM: 106410,600919) PREDICTED: anky (1886) 179 41.5 0.0074
XP_016863578 (OMIM: 106410,600919) PREDICTED: anky (1887) 179 41.5 0.0074
>>NP_004927 (OMIM: 600431) cyclin-dependent kinase 4 inh (138 aa)
initn: 905 init1: 905 opt: 905 Z-score: 838.0 bits: 160.9 E(85289): 6.2e-40
Smith-Waterman score: 905; 99.3% identity (99.3% similar) in 138 aa overlap (1-138:1-138)
10 20 30 40 50 60
pF1KB8 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMDSAR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_004 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA
70 80 90 100 110 120
130
pF1KB8 EERGHRDVAGYLRTATGD
::::::::::::::::::
NP_004 EERGHRDVAGYLRTATGD
130
>>NP_000068 (OMIM: 155601,155755,600160,606719) cyclin-d (156 aa)
initn: 737 init1: 676 opt: 682 Z-score: 636.9 bits: 123.8 E(85289): 9.7e-29
Smith-Waterman score: 682; 82.0% identity (88.7% similar) in 133 aa overlap (9-137:3-135)
10 20 30 40 50
pF1KB8 MREENKGMPSGGGSDEG----LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM
:..:.: : ::.::::: ::.:: :::::: ::. : .::: ::::::
NP_000 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 DSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP
60 70 80 90 100 110
120 130
pF1KB8 VDLAEERGHRDVAGYLRTATGD
:::::: :::::: :::.:.:
NP_000 VDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD
120 130 140 150
>>NP_001182061 (OMIM: 155601,155755,600160,606719) cycli (167 aa)
initn: 737 init1: 676 opt: 682 Z-score: 636.6 bits: 123.9 E(85289): 1e-28
Smith-Waterman score: 682; 82.0% identity (88.7% similar) in 133 aa overlap (9-137:3-135)
10 20 30 40 50
pF1KB8 MREENKGMPSGGGSDEG----LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM
:..:.: : ::.::::: ::.:: :::::: ::. : .::: ::::::
NP_001 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 DSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP
60 70 80 90 100 110
120 130
pF1KB8 VDLAEERGHRDVAGYLRTATGD
:::::: :::::: :::.:.:
NP_001 VDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSEMIGNHLWVCRSRHA
120 130 140 150 160
>>XP_011515978 (OMIM: 155601,155755,600160,606719) PREDI (172 aa)
initn: 737 init1: 676 opt: 682 Z-score: 636.4 bits: 123.9 E(85289): 1e-28
Smith-Waterman score: 682; 82.0% identity (88.7% similar) in 133 aa overlap (9-137:3-135)
10 20 30 40 50
pF1KB8 MREENKGMPSGGGSDEG----LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM
:..:.: : ::.::::: ::.:: :::::: ::. : .::: ::::::
XP_011 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 DSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP
60 70 80 90 100 110
120 130
pF1KB8 VDLAEERGHRDVAGYLRTATGD
:::::: :::::: :::.:.:
XP_011 VDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSVTASIQVPGGEEGDFGSSYS
120 130 140 150 160 170
>>XP_011515977 (OMIM: 155601,155755,600160,606719) PREDI (184 aa)
initn: 737 init1: 676 opt: 682 Z-score: 636.1 bits: 123.9 E(85289): 1.1e-28
Smith-Waterman score: 682; 82.0% identity (88.7% similar) in 133 aa overlap (9-137:3-135)
10 20 30 40 50
pF1KB8 MREENKGMPSGGGSDEG----LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM
:..:.: : ::.::::: ::.:: :::::: ::. : .::: ::::::
XP_011 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 DSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLP
60 70 80 90 100 110
120 130
pF1KB8 VDLAEERGHRDVAGYLRTATGD
:::::: :::::: :::.:.:
XP_011 VDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSAGWTNLRISKPNCAWHHLEISR
120 130 140 150 160 170
>>XP_005251400 (OMIM: 155601,155755,600160,606719) PREDI (105 aa)
initn: 585 init1: 522 opt: 522 Z-score: 495.1 bits: 97.0 E(85289): 7.7e-21
Smith-Waterman score: 522; 94.0% identity (96.4% similar) in 84 aa overlap (54-137:1-84)
30 40 50 60 70 80
pF1KB8 RGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMDSARVAELLLLHGAEPNCADPATLTRP
::: ::::::::::::::::::::::::::
XP_005 MMMGSARVAELLLLHGAEPNCADPATLTRP
10 20 30
90 100 110 120 130
pF1KB8 VHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD
::::::::::::::::::::::::::::::::::::::: :::::: :::.:.:
XP_005 VHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSN
40 50 60 70 80 90
XP_005 HARIDAAEGPSDIPD
100
>>XP_011515981 (OMIM: 155601,155755,600160,606719) PREDI (105 aa)
initn: 585 init1: 522 opt: 522 Z-score: 495.1 bits: 97.0 E(85289): 7.7e-21
Smith-Waterman score: 522; 94.0% identity (96.4% similar) in 84 aa overlap (54-137:1-84)
30 40 50 60 70 80
pF1KB8 RGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMDSARVAELLLLHGAEPNCADPATLTRP
::: ::::::::::::::::::::::::::
XP_011 MMMGSARVAELLLLHGAEPNCADPATLTRP
10 20 30
90 100 110 120 130
pF1KB8 VHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD
::::::::::::::::::::::::::::::::::::::: :::::: :::.:.:
XP_011 VHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSN
40 50 60 70 80 90
XP_011 HARIDAAEGPSDIPD
100
>>NP_511042 (OMIM: 600431) cyclin-dependent kinase 4 inh (78 aa)
initn: 387 init1: 344 opt: 344 Z-score: 336.7 bits: 67.3 E(85289): 5.2e-12
Smith-Waterman score: 344; 100.0% identity (100.0% similar) in 53 aa overlap (1-53:1-53)
10 20 30 40 50 60
pF1KB8 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMDSAR
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_511 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVAGAPGPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA
NP_511 RQGARERGARPRRIGAGT
70
>>NP_524145 (OMIM: 600927) cyclin-dependent kinase 4 inh (166 aa)
initn: 363 init1: 208 opt: 333 Z-score: 323.0 bits: 65.8 E(85289): 3e-11
Smith-Waterman score: 333; 50.9% identity (75.0% similar) in 116 aa overlap (18-132:12-126)
10 20 30 40 50
pF1KB8 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAG-ADPNGVNRFGRRAIQVMMMDSA
:..::::: :..::.::. . :...::::. :.::::. :.
NP_524 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGST
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 RVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDL
.: :: .:: :: : .. : ::::::: :::::: :: . :: ..: :. : ::. :
NP_524 AIALELLKQGASPNVQD-TSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHL
60 70 80 90 100 110
120 130
pF1KB8 AEERGHRDVAGYLRTATGD
: ..:: :...:
NP_524 AVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
120 130 140 150 160
>>NP_001791 (OMIM: 600927) cyclin-dependent kinase 4 inh (166 aa)
initn: 363 init1: 208 opt: 333 Z-score: 323.0 bits: 65.8 E(85289): 3e-11
Smith-Waterman score: 333; 50.9% identity (75.0% similar) in 116 aa overlap (18-132:12-126)
10 20 30 40 50
pF1KB8 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAG-ADPNGVNRFGRRAIQVMMMDSA
:..::::: :..::.::. . :...::::. :.::::. :.
NP_001 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGST
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 RVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDL
.: :: .:: :: : .. : ::::::: :::::: :: . :: ..: :. : ::. :
NP_001 AIALELLKQGASPNVQD-TSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHL
60 70 80 90 100 110
120 130
pF1KB8 AEERGHRDVAGYLRTATGD
: ..:: :...:
NP_001 AVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
120 130 140 150 160
138 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 01:32:50 2016 done: Sat Nov 5 01:32:51 2016
Total Scan time: 4.990 Total Display time: -0.040
Function used was FASTA [36.3.4 Apr, 2011]