Result of FASTA (omim) for
pFN21AB7680
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7680, 406 aa
1>>>pF1KB7680 406 - 406 aa - 406 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.0053+/-0.000386; mu= 5.2419+/- 0.024
mean_var=430.2708+/-88.405, 0's: 0 Z-trim(124.4): 21 B-trim: 0 in 0/60
Lambda= 0.061831
statistics sampled from 46079 (46129) to 46079 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.812), E-opt: 0.2 (0.541), width: 16
Scan time: 11.370
The best scores are: opt bits E(85289)
NP_002922 (OMIM: 602045) E3 ubiquitin-protein liga ( 406) 2796 263.2 8.4e-70
XP_011508153 (OMIM: 608985) PREDICTED: E3 ubiquiti ( 336) 882 92.3 1.9e-18
XP_011508154 (OMIM: 608985) PREDICTED: E3 ubiquiti ( 336) 882 92.3 1.9e-18
NP_009143 (OMIM: 608985) E3 ubiquitin-protein liga ( 336) 882 92.3 1.9e-18
XP_005245470 (OMIM: 608985) PREDICTED: E3 ubiquiti ( 287) 674 73.7 6.7e-13
>>NP_002922 (OMIM: 602045) E3 ubiquitin-protein ligase R (406 aa)
initn: 2796 init1: 2796 opt: 2796 Z-score: 1374.1 bits: 263.2 E(85289): 8.4e-70
Smith-Waterman score: 2796; 100.0% identity (100.0% similar) in 406 aa overlap (1-406:1-406)
10 20 30 40 50 60
pF1KB7 MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 TKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEGE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 GDGEDVSSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRGGTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GDGEDVSSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRGGTLG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 GGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 LRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGVSEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGVSEKQ
310 320 330 340 350 360
370 380 390 400
pF1KB7 YTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
370 380 390 400
>>XP_011508153 (OMIM: 608985) PREDICTED: E3 ubiquitin-pr (336 aa)
initn: 1379 init1: 872 opt: 882 Z-score: 452.2 bits: 92.3 E(85289): 1.9e-18
Smith-Waterman score: 1244; 55.2% identity (69.8% similar) in 400 aa overlap (8-406:11-336)
10 20 30 40 50
pF1KB7 MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKN
: :::::::::::.::::::: :: ::.:::::::::::::::::::::
XP_011 MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 TMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEY
::::::::::::.:::.::::::::::::::::::::::::::::::::::::::::.::
XP_011 TMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 EAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPG
::::.::: :... .:::::: ::::::..:::.: :: :. : . .: : .
XP_011 EAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQR------GKKQ--QIENGSG--A
130 140 150 160 170
180 190 200 210 220 230
pF1KB7 EGEGDGEDVSSDSA-PDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRG
: .::. :. :. .. ::. :: . :.::: .
XP_011 EDNGDSSHCSNASTHSNQEAGPSNKRTKT-----------------------SDDSGLEL
180 190 200
240 250 260 270 280 290
pF1KB7 GTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLS
. ... : :: .:::::::::: :.:: . ::::.::.:::::::::
XP_011 DNNNAAMAIDPVMDGA-------SEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLS
210 220 230 240 250 260
300 310 320 330 340 350
pF1KB7 KYLALRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGV
::::.:.:::. ... ::.. .:. .
XP_011 KYLAVRLALEELRSK----------------------GESNQM------------NLDTA
270 280
360 370 380 390 400
pF1KB7 SEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
:::::::::: ..: ::.::::..::::.::.:::..:.:: :::::. :
XP_011 SEKQYTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKEHK
290 300 310 320 330
>>XP_011508154 (OMIM: 608985) PREDICTED: E3 ubiquitin-pr (336 aa)
initn: 1379 init1: 872 opt: 882 Z-score: 452.2 bits: 92.3 E(85289): 1.9e-18
Smith-Waterman score: 1244; 55.2% identity (69.8% similar) in 400 aa overlap (8-406:11-336)
10 20 30 40 50
pF1KB7 MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKN
: :::::::::::.::::::: :: ::.:::::::::::::::::::::
XP_011 MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 TMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEY
::::::::::::.:::.::::::::::::::::::::::::::::::::::::::::.::
XP_011 TMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 EAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPG
::::.::: :... .:::::: ::::::..:::.: :: :. : . .: : .
XP_011 EAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQR------GKKQ--QIENGSG--A
130 140 150 160 170
180 190 200 210 220 230
pF1KB7 EGEGDGEDVSSDSA-PDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRG
: .::. :. :. .. ::. :: . :.::: .
XP_011 EDNGDSSHCSNASTHSNQEAGPSNKRTKT-----------------------SDDSGLEL
180 190 200
240 250 260 270 280 290
pF1KB7 GTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLS
. ... : :: .:::::::::: :.:: . ::::.::.:::::::::
XP_011 DNNNAAMAIDPVMDGA-------SEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLS
210 220 230 240 250 260
300 310 320 330 340 350
pF1KB7 KYLALRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGV
::::.:.:::. ... ::.. .:. .
XP_011 KYLAVRLALEELRSK----------------------GESNQM------------NLDTA
270 280
360 370 380 390 400
pF1KB7 SEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
:::::::::: ..: ::.::::..::::.::.:::..:.:: :::::. :
XP_011 SEKQYTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKEHK
290 300 310 320 330
>>NP_009143 (OMIM: 608985) E3 ubiquitin-protein ligase R (336 aa)
initn: 1379 init1: 872 opt: 882 Z-score: 452.2 bits: 92.3 E(85289): 1.9e-18
Smith-Waterman score: 1244; 55.2% identity (69.8% similar) in 400 aa overlap (8-406:11-336)
10 20 30 40 50
pF1KB7 MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKN
: :::::::::::.::::::: :: ::.:::::::::::::::::::::
NP_009 MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 TMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEY
::::::::::::.:::.::::::::::::::::::::::::::::::::::::::::.::
NP_009 TMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 EAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPG
::::.::: :... .:::::: ::::::..:::.: :: :. : . .: : .
NP_009 EAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQR------GKKQ--QIENGSG--A
130 140 150 160 170
180 190 200 210 220 230
pF1KB7 EGEGDGEDVSSDSA-PDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRG
: .::. :. :. .. ::. :: . :.::: .
NP_009 EDNGDSSHCSNASTHSNQEAGPSNKRTKT-----------------------SDDSGLEL
180 190 200
240 250 260 270 280 290
pF1KB7 GTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLS
. ... : :: .:::::::::: :.:: . ::::.::.:::::::::
NP_009 DNNNAAMAIDPVMDGA-------SEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLS
210 220 230 240 250 260
300 310 320 330 340 350
pF1KB7 KYLALRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGV
::::.:.:::. ... ::.. .:. .
NP_009 KYLAVRLALEELRSK----------------------GESNQM------------NLDTA
270 280
360 370 380 390 400
pF1KB7 SEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
:::::::::: ..: ::.::::..::::.::.:::..:.:: :::::. :
NP_009 SEKQYTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKEHK
290 300 310 320 330
>>XP_005245470 (OMIM: 608985) PREDICTED: E3 ubiquitin-pr (287 aa)
initn: 1174 init1: 667 opt: 674 Z-score: 352.6 bits: 73.7 E(85289): 6.7e-13
Smith-Waterman score: 1036; 52.1% identity (67.6% similar) in 361 aa overlap (47-406:1-287)
20 30 40 50 60 70
pF1KB7 SLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCSDCIVTA
:::::::::::::::::::::::.:::.::
XP_005 MCPICLDMLKNTMTTKECLHRFCADCIITA
10 20 30
80 90 100 110 120 130
pF1KB7 LRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSRLHNQQA
::::::::::::::::::::::::::::::::::::::.::::::.::: :... .::::
XP_005 LRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQA
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB7 LSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEGEGDGEDVSSDSA-PDSA
:: ::::::..:::.: :: :. : . .: : .: .::. :. :. ..
XP_005 LSHSIEEGLKIQAMNRLQR------GKKQQ--IENGSG--AEDNGDSSHCSNASTHSNQE
100 110 120 130 140
200 210 220 230 240 250
pF1KB7 PGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSP
::. :: . :.::: . . ... : ::
XP_005 AGPSNKRTKT-----------------------SDDSGLELDNNNAAMAIDPVMDGA---
150 160 170
260 270 280 290 300 310
pF1KB7 PEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQEAGE
.:::::::::: :.:: . ::::.::.:::::::::::::.:.:::. ...
XP_005 ----SEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSK----
180 190 200 210 220
320 330 340 350 360 370
pF1KB7 PGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTL
::.. .:. .:::::::::: ..: ::.:
XP_005 ------------------GESNQM------------NLDTASEKQYTIYIATASGQFTVL
230 240 250
380 390 400
pF1KB7 NGSLTLELVNEKFWKVSRPLELCYAPTKDPK
:::..::::.::.:::..:.:: :::::. :
XP_005 NGSFSLELVSEKYWKVNKPMELYYAPTKEHK
260 270 280
406 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 21:32:01 2016 done: Fri Nov 4 21:32:03 2016
Total Scan time: 11.370 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]