Result of FASTA (omim) for
pFN21AE0413
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0413, 334 aa
1>>>pF1KE0413 334 - 334 aa - 334 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9862+/-0.000394; mu= 17.6898+/- 0.024
mean_var=66.9364+/-13.310, 0's: 0 Z-trim(111.8): 25 B-trim: 35 in 1/54
Lambda= 0.156763
statistics sampled from 20490 (20510) to 20490 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.24), width: 16
Scan time: 7.610
The best scores are: opt bits E(85289)
NP_037415 (OMIM: 605527) methionine adenosyltransf ( 334) 2253 518.6 7.1e-147
NP_877725 (OMIM: 605527) methionine adenosyltransf ( 323) 2113 487.0 2.4e-137
XP_011519367 (OMIM: 616145,616146) PREDICTED: dTDP ( 318) 139 40.5 0.0057
NP_001291359 (OMIM: 616145,616146) dTDP-D-glucose ( 318) 139 40.5 0.0057
XP_011519368 (OMIM: 616145,616146) PREDICTED: dTDP ( 318) 139 40.5 0.0057
NP_055120 (OMIM: 616145,616146) dTDP-D-glucose 4,6 ( 350) 139 40.6 0.0062
>>NP_037415 (OMIM: 605527) methionine adenosyltransferas (334 aa)
initn: 2253 init1: 2253 opt: 2253 Z-score: 2757.9 bits: 518.6 E(85289): 7.1e-147
Smith-Waterman score: 2253; 99.7% identity (99.7% similar) in 334 aa overlap (1-334:1-334)
10 20 30 40 50 60
pF1KE0 MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 RRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 AKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 AKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 RIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 RIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRML
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 DPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQCPRNAQLDCSKL
:::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::
NP_037 DPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKL
250 260 270 280 290 300
310 320 330
pF1KE0 ETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
::::::::::::::::::::::::::::::::::
NP_037 ETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
310 320 330
>>NP_877725 (OMIM: 605527) methionine adenosyltransferas (323 aa)
initn: 2113 init1: 2113 opt: 2113 Z-score: 2586.9 bits: 487.0 E(85289): 2.4e-137
Smith-Waterman score: 2113; 99.4% identity (99.7% similar) in 314 aa overlap (21-334:10-323)
10 20 30 40 50 60
pF1KE0 MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGF
.:::::::::::::::::::::::::::::::::::::::
NP_877 MPEMPEDMEQEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGF
10 20 30 40
70 80 90 100 110 120
pF1KE0 RRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_877 RRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE0 AKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_877 AKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVL
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE0 RIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_877 RIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRML
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE0 DPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQCPRNAQLDCSKL
:::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::
NP_877 DPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKL
230 240 250 260 270 280
310 320 330
pF1KE0 ETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
::::::::::::::::::::::::::::::::::
NP_877 ETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
290 300 310 320
>>XP_011519367 (OMIM: 616145,616146) PREDICTED: dTDP-D-g (318 aa)
initn: 87 init1: 58 opt: 139 Z-score: 174.3 bits: 40.5 E(85289): 0.0057
Smith-Waterman score: 139; 21.8% identity (52.1% similar) in 284 aa overlap (66-334:39-304)
40 50 60 70 80 90
pF1KE0 ATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAA
:: : .. ::. :. ... . ...: ::
XP_011 YPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAA
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE0 ERRPDVVENQPDAASQLNVDASGNLAKEA--AAVGAFLIYISSDYVFDGTNPPYREEDIP
. . :. . . .:: .. :.. : : : : ::.:.: :. :. .:. :
XP_011 QTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKF-IYVSTDEVYGGSLDKEFDESSP
70 80 90 100 110 120
160 170 180 190 200
pF1KE0 A-PLNLYGKTKLDGEKAVL----ENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSN
: : :...: .: : . .. ... : .:: .. :... ... .: .
XP_011 KQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGP-HQYPEKVIPKFISLLQHNR
130 140 150 160 170 180
210 220 230 240 250 260
pF1KE0 KSA-NMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSG-NEQMTKYEMACAIA
: . . : : .. ::. : .: . : .. : : .:. ..: .
XP_011 KCCIHGSGLQTRNFLYATDVVE-----AFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELI
190 200 210 220 230 240
270 280 290 300 310 320
pF1KE0 DAFNLPSSH------LRPITDSPVLGAQCPRNAQLDCSKLETLGIGQRTPFRIGIKESLW
. .. .:. . ..: :. . : ... :.. :: ..:.. :::...
XP_011 QLIKETNSESEMENWVDYVNDRPTNDMRYPMKSE----KIHGLGWRPKVPWKEGIKKTI-
250 260 270 280 290
330
pF1KE0 PFLIDKRWRQTVFH
.: . ::
XP_011 ------EWYRENFHNWKNVEKALEPFPV
300 310
>>NP_001291359 (OMIM: 616145,616146) dTDP-D-glucose 4,6- (318 aa)
initn: 87 init1: 58 opt: 139 Z-score: 174.3 bits: 40.5 E(85289): 0.0057
Smith-Waterman score: 139; 21.8% identity (52.1% similar) in 284 aa overlap (66-334:39-304)
40 50 60 70 80 90
pF1KE0 ATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAA
:: : .. ::. :. ... . ...: ::
NP_001 YPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAA
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE0 ERRPDVVENQPDAASQLNVDASGNLAKEA--AAVGAFLIYISSDYVFDGTNPPYREEDIP
. . :. . . .:: .. :.. : : : : ::.:.: :. :. .:. :
NP_001 QTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKF-IYVSTDEVYGGSLDKEFDESSP
70 80 90 100 110 120
160 170 180 190 200
pF1KE0 A-PLNLYGKTKLDGEKAVL----ENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSN
: : :...: .: : . .. ... : .:: .. :... ... .: .
NP_001 KQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGP-HQYPEKVIPKFISLLQHNR
130 140 150 160 170 180
210 220 230 240 250 260
pF1KE0 KSA-NMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSG-NEQMTKYEMACAIA
: . . : : .. ::. : .: . : .. : : .:. ..: .
NP_001 KCCIHGSGLQTRNFLYATDVVE-----AFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELI
190 200 210 220 230 240
270 280 290 300 310 320
pF1KE0 DAFNLPSSH------LRPITDSPVLGAQCPRNAQLDCSKLETLGIGQRTPFRIGIKESLW
. .. .:. . ..: :. . : ... :.. :: ..:.. :::...
NP_001 QLIKETNSESEMENWVDYVNDRPTNDMRYPMKSE----KIHGLGWRPKVPWKEGIKKTI-
250 260 270 280 290
330
pF1KE0 PFLIDKRWRQTVFH
.: . ::
NP_001 ------EWYRENFHNWKNVEKALEPFPV
300 310
>>XP_011519368 (OMIM: 616145,616146) PREDICTED: dTDP-D-g (318 aa)
initn: 87 init1: 58 opt: 139 Z-score: 174.3 bits: 40.5 E(85289): 0.0057
Smith-Waterman score: 139; 21.8% identity (52.1% similar) in 284 aa overlap (66-334:39-304)
40 50 60 70 80 90
pF1KE0 ATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAA
:: : .. ::. :. ... . ...: ::
XP_011 YPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAA
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE0 ERRPDVVENQPDAASQLNVDASGNLAKEA--AAVGAFLIYISSDYVFDGTNPPYREEDIP
. . :. . . .:: .. :.. : : : : ::.:.: :. :. .:. :
XP_011 QTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKF-IYVSTDEVYGGSLDKEFDESSP
70 80 90 100 110 120
160 170 180 190 200
pF1KE0 A-PLNLYGKTKLDGEKAVL----ENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSN
: : :...: .: : . .. ... : .:: .. :... ... .: .
XP_011 KQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGP-HQYPEKVIPKFISLLQHNR
130 140 150 160 170 180
210 220 230 240 250 260
pF1KE0 KSA-NMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSG-NEQMTKYEMACAIA
: . . : : .. ::. : .: . : .. : : .:. ..: .
XP_011 KCCIHGSGLQTRNFLYATDVVE-----AFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELI
190 200 210 220 230 240
270 280 290 300 310 320
pF1KE0 DAFNLPSSH------LRPITDSPVLGAQCPRNAQLDCSKLETLGIGQRTPFRIGIKESLW
. .. .:. . ..: :. . : ... :.. :: ..:.. :::...
XP_011 QLIKETNSESEMENWVDYVNDRPTNDMRYPMKSE----KIHGLGWRPKVPWKEGIKKTI-
250 260 270 280 290
330
pF1KE0 PFLIDKRWRQTVFH
.: . ::
XP_011 ------EWYRENFHNWKNVEKALEPFPV
300 310
>>NP_055120 (OMIM: 616145,616146) dTDP-D-glucose 4,6-deh (350 aa)
initn: 122 init1: 58 opt: 139 Z-score: 173.7 bits: 40.6 E(85289): 0.0062
Smith-Waterman score: 140; 21.3% identity (51.1% similar) in 348 aa overlap (21-334:7-336)
10 20 30 40 50
pF1KE0 MVGREKELSIHFVPGSCRLVEEEVNIPN---RRVLVTGATGLLGRAVHKEFQQN--NWHA
:: ..:. .::::::..:... . . .. :.
NP_055 MSAACWEEPWGLPGGFAKRVLVTGGAGFIASHMIVSLVEDYPNYMI
10 20 30 40
60 70 80 90 100
pF1KE0 VG------CGF--------RRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDV
.. :. . :: : .. ::. :. ... . ...: ::. . :.
NP_055 INLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDL
50 60 70 80 90 100
110 120 130 140 150
pF1KE0 VENQPDAASQLNVDASGNLAKEA--AAVGAFLIYISSDYVFDGTNPPYREEDIPA-PLNL
. . .:: .. :.. : : : : ::.:.: :. :. .:. : : :
NP_055 SFVRAFEFTYVNVYGTHVLVSAAHEARVEKF-IYVSTDEVYGGSLDKEFDESSPKQPTNP
110 120 130 140 150 160
160 170 180 190 200 210
pF1KE0 YGKTKLDGEKAVL----ENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSNKSA-NM
:...: .: : . .. ... : .:: .. :... ... .: . : .
NP_055 YASSKAAAECFVQSYWEQYKFPVVITRSSNVYGP-HQYPEKVIPKFISLLQHNRKCCIHG
170 180 190 200 210 220
220 230 240 250 260 270
pF1KE0 DHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSG-NEQMTKYEMACAIADAFNLP
. : : .. ::. : .: . : .. : : .:. ..: . . ..
NP_055 SGLQTRNFLYATDVVE-----AFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELIQLIKET
230 240 250 260 270
280 290 300 310 320
pF1KE0 SSH------LRPITDSPVLGAQCPRNAQLDCSKLETLGIGQRTPFRIGIKESLWPFLIDK
.:. . ..: :. . : ... :.. :: ..:.. :::...
NP_055 NSESEMENWVDYVNDRPTNDMRYPMKSE----KIHGLGWRPKVPWKEGIKKTI-------
280 290 300 310 320
330
pF1KE0 RWRQTVFH
.: . ::
NP_055 EWYRENFHNWKNVEKALEPFPV
330 340 350
334 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 11:37:56 2016 done: Thu Nov 3 11:37:57 2016
Total Scan time: 7.610 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]