FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0359, 582 aa 1>>>pF1KE0359 582 - 582 aa - 582 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.4817+/-0.000333; mu= 10.3918+/- 0.021 mean_var=150.5999+/-31.025, 0's: 0 Z-trim(120.3): 107 B-trim: 1420 in 1/55 Lambda= 0.104511 statistics sampled from 35322 (35437) to 35322 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.745), E-opt: 0.2 (0.415), width: 16 Scan time: 9.230 The best scores are: opt bits E(85289) NP_001518 (OMIM: 605164) histone deacetylase 2 [Ho ( 488) 3343 515.7 1.4e-145 XP_016866288 (OMIM: 605164) PREDICTED: histone dea ( 458) 3116 481.5 2.6e-135 XP_011534090 (OMIM: 605164) PREDICTED: histone dea ( 458) 3116 481.5 2.6e-135 NP_004955 (OMIM: 601241) histone deacetylase 1 [Ho ( 482) 2880 445.9 1.4e-124 NP_003874 (OMIM: 605166) histone deacetylase 3 [Ho ( 428) 1833 288.0 4.3e-77 XP_011539611 (OMIM: 601241) PREDICTED: histone dea ( 289) 1614 254.9 2.7e-67 NP_060956 (OMIM: 300269) histone deacetylase 8 iso ( 377) 1089 175.8 2.3e-43 XP_011529288 (OMIM: 300269) PREDICTED: histone dea ( 441) 1083 174.9 4.8e-43 XP_011529289 (OMIM: 300269) PREDICTED: histone dea ( 379) 992 161.2 5.8e-39 XP_011535999 (OMIM: 605166) PREDICTED: histone dea ( 241) 933 152.1 1.9e-36 XP_016885135 (OMIM: 300269) PREDICTED: histone dea ( 274) 882 144.5 4.4e-34 NP_001159890 (OMIM: 300269) histone deacetylase 8 ( 286) 821 135.3 2.7e-31 XP_016885131 (OMIM: 300269) PREDICTED: histone dea ( 350) 816 134.6 5.3e-31 NP_001159891 (OMIM: 300269) histone deacetylase 8 ( 256) 721 120.2 8.5e-27 XP_016885130 (OMIM: 300269) PREDICTED: histone dea ( 389) 536 92.4 2.9e-18 XP_016885133 (OMIM: 300269) PREDICTED: histone dea ( 324) 530 91.4 4.8e-18 XP_016885129 (OMIM: 300269) PREDICTED: histone dea ( 415) 530 91.5 5.8e-18 XP_016885136 (OMIM: 300269) PREDICTED: histone dea ( 268) 469 82.2 2.4e-15 NP_001308157 (OMIM: 300272,300863) histone deacety (1215) 389 70.6 3.4e-11 NP_006035 (OMIM: 300272,300863) histone deacetylas (1215) 389 70.6 3.4e-11 NP_001308156 (OMIM: 300272,300863) histone deacety (1215) 389 70.6 3.4e-11 NP_001308158 (OMIM: 300272,300863) histone deacety (1215) 389 70.6 3.4e-11 NP_001308155 (OMIM: 300272,300863) histone deacety (1215) 389 70.6 3.4e-11 NP_001308154 (OMIM: 300272,300863) histone deacety (1229) 389 70.6 3.4e-11 XP_016885134 (OMIM: 300269) PREDICTED: histone dea ( 315) 374 67.9 5.6e-11 XP_016885132 (OMIM: 300269) PREDICTED: histone dea ( 341) 368 67.0 1.1e-10 XP_016868317 (OMIM: 606543) PREDICTED: histone dea (1025) 368 67.4 2.6e-10 NP_001308806 (OMIM: 606543) histone deacetylase 9 (1025) 368 67.4 2.6e-10 NP_001308826 (OMIM: 606543) histone deacetylase 9 (1025) 368 67.4 2.6e-10 XP_011513948 (OMIM: 606543) PREDICTED: histone dea (1035) 368 67.4 2.7e-10 XP_011513947 (OMIM: 606543) PREDICTED: histone dea (1038) 368 67.4 2.7e-10 XP_011513946 (OMIM: 606543) PREDICTED: histone dea (1038) 368 67.4 2.7e-10 XP_016868316 (OMIM: 606543) PREDICTED: histone dea (1043) 368 67.4 2.7e-10 XP_011513944 (OMIM: 606543) PREDICTED: histone dea (1043) 368 67.4 2.7e-10 XP_011513943 (OMIM: 606543) PREDICTED: histone dea (1043) 368 67.4 2.7e-10 XP_011513936 (OMIM: 606543) PREDICTED: histone dea (1044) 368 67.4 2.7e-10 NP_001308797 (OMIM: 606543) histone deacetylase 9 (1044) 368 67.4 2.7e-10 NP_848510 (OMIM: 606543) histone deacetylase 9 iso (1066) 368 67.4 2.7e-10 XP_016868315 (OMIM: 606543) PREDICTED: histone dea (1066) 368 67.4 2.7e-10 XP_011513940 (OMIM: 606543) PREDICTED: histone dea (1069) 368 67.4 2.7e-10 XP_011513941 (OMIM: 606543) PREDICTED: histone dea (1069) 368 67.4 2.7e-10 NP_848512 (OMIM: 606543) histone deacetylase 9 iso (1069) 368 67.4 2.7e-10 XP_011513939 (OMIM: 606543) PREDICTED: histone dea (1071) 368 67.4 2.7e-10 XP_011513938 (OMIM: 606543) PREDICTED: histone dea (1071) 368 67.4 2.7e-10 XP_011513950 (OMIM: 606543) PREDICTED: histone dea (1074) 368 67.4 2.7e-10 XP_011513937 (OMIM: 606543) PREDICTED: histone dea (1074) 368 67.4 2.7e-10 XP_011513951 (OMIM: 606543) PREDICTED: histone dea (1074) 368 67.4 2.7e-10 XP_011513931 (OMIM: 606543) PREDICTED: histone dea (1088) 368 67.4 2.8e-10 XP_011513933 (OMIM: 606543) PREDICTED: histone dea (1096) 368 67.4 2.8e-10 NP_478056 (OMIM: 606543) histone deacetylase 9 iso (1011) 342 63.5 4e-09 >>NP_001518 (OMIM: 605164) histone deacetylase 2 [Homo s (488 aa) initn: 3343 init1: 3343 opt: 3343 Z-score: 2734.7 bits: 515.7 E(85289): 1.4e-145 Smith-Waterman score: 3343; 100.0% identity (100.0% similar) in 488 aa overlap (95-582:1-488) 70 80 90 100 110 120 pF1KE0 PFLSRPSRGGSSSSSSSRRRSPVAAVAGEPMAYSQGGGKKKVCYYYDGDIGNYYYGQGHP :::::::::::::::::::::::::::::: NP_001 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHP 10 20 30 130 140 150 160 170 180 pF1KE0 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSK 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE0 QMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASG 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE0 FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTG 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE0 DLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE0 RLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELP 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE0 YNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAV 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE0 HEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEED 400 410 420 430 440 450 550 560 570 580 pF1KE0 KKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP :::::::::::::::::::::::::::::::::::::: NP_001 KKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP 460 470 480 >>XP_016866288 (OMIM: 605164) PREDICTED: histone deacety (458 aa) initn: 3116 init1: 3116 opt: 3116 Z-score: 2550.2 bits: 481.5 E(85289): 2.6e-135 Smith-Waterman score: 3116; 100.0% identity (100.0% similar) in 458 aa overlap (125-582:1-458) 100 110 120 130 140 150 pF1KE0 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA :::::::::::::::::::::::::::::: XP_016 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKA 10 20 30 160 170 180 190 200 210 pF1KE0 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE0 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE0 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE0 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE0 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM 280 290 300 310 320 330 460 470 480 490 500 510 pF1KE0 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE 340 350 360 370 380 390 520 530 540 550 560 570 pF1KE0 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT 400 410 420 430 440 450 580 pF1KE0 KSEQLSNP :::::::: XP_016 KSEQLSNP >>XP_011534090 (OMIM: 605164) PREDICTED: histone deacety (458 aa) initn: 3116 init1: 3116 opt: 3116 Z-score: 2550.2 bits: 481.5 E(85289): 2.6e-135 Smith-Waterman score: 3116; 100.0% identity (100.0% similar) in 458 aa overlap (125-582:1-458) 100 110 120 130 140 150 pF1KE0 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA :::::::::::::::::::::::::::::: XP_011 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKA 10 20 30 160 170 180 190 200 210 pF1KE0 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE0 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE0 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE0 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE0 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM 280 290 300 310 320 330 460 470 480 490 500 510 pF1KE0 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE 340 350 360 370 380 390 520 530 540 550 560 570 pF1KE0 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT 400 410 420 430 440 450 580 pF1KE0 KSEQLSNP :::::::: XP_011 KSEQLSNP >>NP_004955 (OMIM: 601241) histone deacetylase 1 [Homo s (482 aa) initn: 2924 init1: 2811 opt: 2880 Z-score: 2357.5 bits: 445.9 E(85289): 1.4e-124 Smith-Waterman score: 2880; 85.9% identity (95.0% similar) in 483 aa overlap (95-577:1-478) 70 80 90 100 110 120 pF1KE0 PFLSRPSRGGSSSSSSSRRRSPVAAVAGEPMAYSQGGGKKKVCYYYDGDIGNYYYGQGHP :: .:: ..:::::::::.:::::::::: NP_004 MAQTQGT-RRKVCYYYDGDVGNYYYGQGHP 10 20 130 140 150 160 170 180 pF1KE0 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSK ::::::::::::::::::::::::::::::.::::::::::.:::::::::::::::::: NP_004 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSK 30 40 50 60 70 80 190 200 210 220 230 240 pF1KE0 QMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASG ::::::::::::::::::::::::::::::.:::::.::::.:::::::::::::::::: NP_004 QMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASG 90 100 110 120 130 140 250 260 270 280 290 300 pF1KE0 FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTG 150 160 170 180 190 200 310 320 330 340 350 360 pF1KE0 DLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD ::::::::::::::::.:.::::::::: ::::..::::::.::::::::::.:::::: NP_004 DLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGD 210 220 230 240 250 260 370 380 390 400 410 420 pF1KE0 RLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELP ::::::::.:::::::: ::.::::.:::::::::::::::::::::::::: ::::::: NP_004 RLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELP 270 280 290 300 310 320 430 440 450 460 470 480 pF1KE0 YNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAV :::::::::::::::::::::::::: ::.:::::::::::::::::::::::::::::. NP_004 YNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAI 330 340 350 360 370 380 490 500 510 520 530 540 pF1KE0 HEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEED :.::::: .:::::::: .:::::::.:::::::.::::::.: .. :: ::... :.. NP_004 PEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKK-AKRVKTEDE 390 400 410 420 430 440 550 560 570 580 pF1KE0 KKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP :.. ..: .: ::.:.:. :: ..::.: : NP_004 KEKDPEEKKEVTEEEKTKE---EKPEAKGVKEEVKLA 450 460 470 480 >>NP_003874 (OMIM: 605166) histone deacetylase 3 [Homo s (428 aa) initn: 1131 init1: 978 opt: 1833 Z-score: 1505.1 bits: 288.0 E(85289): 4.3e-77 Smith-Waterman score: 1833; 58.8% identity (84.4% similar) in 422 aa overlap (104-523:3-421) 80 90 100 110 120 130 pF1KE0 GSSSSSSSRRRSPVAAVAGEPMAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMT : : :.:: :.::..:: ::::::::. .: NP_003 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALT 10 20 30 140 150 160 170 180 190 pF1KE0 HNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGE :.:.:.::::.:: ...:..:. ..: ..::..:: ::. . : ::. ..:... ::::. NP_003 HSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGD 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 DCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVL ::::: ::::::. ::.:. ::..:: . :.:.::::::::::: ::::::::::::. NP_003 DCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVI 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE0 AILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAG .:::::::: :::::::::::::::.:::: :::::::::::::.:: :::::. ..:: NP_003 GILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAE 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE0 KGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLT .:.:: .: :.::::::.:: ..:.:.:..:...:::. .:::::::::. ::::::::. NP_003 SGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLS 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE0 VKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYF ..::..::: ::.::.:::.:::::::.:::::::::::.. .. : .::::..::::: NP_003 IRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYF 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE0 GPDFKLHISPSN-MTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDE .::: :: . :. . :::. .:...:.: .::::.:: :::.::.. .: : . : :: NP_003 APDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE 340 350 360 370 380 390 500 510 520 530 540 550 pF1KE0 DGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDK : ..: . . . .: .:: :.. ... NP_003 --ADAEER-GPEENYSRPEAPNEFYDGDHDNDKESDVEI 400 410 420 560 570 580 pF1KE0 KTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP >>XP_011539611 (OMIM: 601241) PREDICTED: histone deacety (289 aa) initn: 1677 init1: 1565 opt: 1614 Z-score: 1329.0 bits: 254.9 E(85289): 2.7e-67 Smith-Waterman score: 1614; 80.6% identity (92.7% similar) in 289 aa overlap (289-577:1-285) 260 270 280 290 300 310 pF1KE0 LKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYA :::::::::::::::::::::::::::::: XP_011 MTVSFHKYGEYFPGTGDLRDIGAGKGKYYA 10 20 30 320 330 340 350 360 370 pF1KE0 VNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAK ::.:.::::::::: ::::..::::::.::::::::::.::::::::::::::.::::: XP_011 VNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAK 40 50 60 70 80 90 380 390 400 410 420 430 pF1KE0 CVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKL ::: ::.::::.:::::::::::::::::::::::::: ::::::::::::::::::::: XP_011 CVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKL 100 110 120 130 140 150 440 450 460 470 480 490 pF1KE0 HISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDK :::::::::::: ::.:::::::::::::::::::::::::::::. :.::::: .:::: XP_011 HISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDK 160 170 180 190 200 210 500 510 520 530 540 550 pF1KE0 RISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEE :::: .:::::::.:::::::.::::::.: .. :: ::... :..:.. ..: .: :: XP_011 RISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKK-AKRVKTEDEKEKDPEEKKEVTEE 220 230 240 250 260 560 570 580 pF1KE0 DKSKDNSGEKTDTKGTKSEQLSNP .:.:. :: ..::.: : XP_011 EKTKE---EKPEAKGVKEEVKLA 270 280 >>NP_060956 (OMIM: 300269) histone deacetylase 8 isoform (377 aa) initn: 953 init1: 551 opt: 1089 Z-score: 899.6 bits: 175.8 E(85289): 2.3e-43 Smith-Waterman score: 1089; 43.4% identity (77.1% similar) in 341 aa overlap (127-466:35-374) 100 110 120 130 140 150 pF1KE0 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA :.: :.:.:. :.:...:.: .:. :. NP_060 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 10 20 30 40 50 60 160 170 180 190 200 210 pF1KE0 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA :::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....: NP_060 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 70 80 90 100 110 120 220 230 240 250 260 270 pF1KE0 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD : . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.:::: NP_060 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD 130 140 150 160 170 180 280 290 300 310 320 330 pF1KE0 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI :::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: :: NP_060 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI 190 200 210 220 230 240 340 350 360 370 380 390 pF1KE0 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG . ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.::: NP_060 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG 250 260 270 280 290 300 400 410 420 430 440 450 pF1KE0 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME :::.. :.:::::: :.: : . .:.: ...: .:::. :.:.:: ..: :. .. NP_060 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQ 310 320 330 340 350 360 460 470 480 490 500 510 pF1KE0 KIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEF .: . . ::. NP_060 QILNYIKGNLKHVV 370 >>XP_011529288 (OMIM: 300269) PREDICTED: histone deacety (441 aa) initn: 525 init1: 525 opt: 1083 Z-score: 893.8 bits: 174.9 E(85289): 4.8e-43 Smith-Waterman score: 1083; 44.0% identity (77.7% similar) in 332 aa overlap (127-457:73-403) 100 110 120 130 140 150 pF1KE0 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA :.: :.:.:. :.:...:.: .:. :. XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE0 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA :::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....: XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE0 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD : . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.:::: XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE0 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI :::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: :: XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI 230 240 250 260 270 280 340 350 360 370 380 390 pF1KE0 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG . ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.::: XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG 290 300 310 320 330 340 400 410 420 430 440 450 pF1KE0 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME :::.. :.:::::: :.: : . .:.: ...: .:::. :.:.:: ..: :. .. XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQ 350 360 370 380 390 400 460 470 480 490 500 510 pF1KE0 KIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEF .: XP_011 QILNYIKEKWPVGFGAQCFYLGKCGKAKTTEGQRNLKHVV 410 420 430 440 >>XP_011529289 (OMIM: 300269) PREDICTED: histone deacety (379 aa) initn: 841 init1: 439 opt: 992 Z-score: 820.5 bits: 161.2 E(85289): 5.8e-39 Smith-Waterman score: 992; 45.2% identity (78.3% similar) in 299 aa overlap (127-424:73-370) 100 110 120 130 140 150 pF1KE0 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA :.: :.:.:. :.:...:.: .:. :. XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE0 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA :::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....: XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE0 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD : . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.:::: XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE0 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI :::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: :: XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI 230 240 250 260 270 280 340 350 360 370 380 390 pF1KE0 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG . ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.::: XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG 290 300 310 320 330 340 400 410 420 430 440 450 pF1KE0 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME :::.. :.:::::: :.: : . .:.: XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHENMPVNT 350 360 370 >>XP_011535999 (OMIM: 605166) PREDICTED: histone deacety (241 aa) initn: 869 init1: 716 opt: 933 Z-score: 775.2 bits: 152.1 E(85289): 1.9e-36 Smith-Waterman score: 933; 54.4% identity (82.3% similar) in 237 aa overlap (289-523:1-234) 260 270 280 290 300 310 pF1KE0 LKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYY :::::::::.:: :::::. ..:: .:.:: XP_011 MTVSFHKYGNYFFPGTGDMYEVGAESGRYY 10 20 30 320 330 340 350 360 370 pF1KE0 AVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHA .: :.::::::.:: ..:.:.:..:...:::. .:::::::::. ::::::::...::. XP_011 CLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG 40 50 60 70 80 90 380 390 400 410 420 430 pF1KE0 KCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFK .::: ::.::.:::.:::::::.:::::::::::.. .. : .::::..:::::.::: XP_011 ECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFT 100 110 120 130 140 150 440 450 460 470 480 490 pF1KE0 LHISPSN-MTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDP :: . :. . :::. .:...:.: .::::.:: :::.::.. .: : . : :: : XP_011 LHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE--ADA 160 170 180 190 200 500 510 520 530 540 550 pF1KE0 DKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVK ..: . . . .: .:: :.. ... XP_011 EER-GPEENYSRPEAPNEFYDGDHDNDKESDVEI 210 220 230 240 582 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 04:00:10 2016 done: Mon Nov 7 04:00:11 2016 Total Scan time: 9.230 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]