Result of FASTA (ccds) for
pFN21AE0353
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0353, 543 aa
1>>>pF1KE0353 543 - 543 aa - 543 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4143+/-0.000827; mu= 13.5111+/- 0.050
mean_var=94.1859+/-18.419, 0's: 0 Z-trim(109.7): 24 B-trim: 0 in 0/52
Lambda= 0.132154
statistics sampled from 11045 (11068) to 11045 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.34), width: 16
Scan time: 3.480
The best scores are: opt bits E(32554)
CCDS5025.1 GJA10 gene_id:84694|Hs108|chr6 ( 543) 3781 731.2 7.6e-211
CCDS432.1 GJA9 gene_id:81025|Hs108|chr1 ( 515) 1213 241.5 1.8e-63
CCDS30834.1 GJA8 gene_id:2703|Hs108|chr1 ( 433) 955 192.3 9.8e-49
CCDS9289.1 GJA3 gene_id:2700|Hs108|chr13 ( 435) 955 192.3 9.9e-49
CCDS929.1 GJA5 gene_id:2702|Hs108|chr1 ( 358) 916 184.8 1.4e-46
CCDS30669.1 GJA4 gene_id:2701|Hs108|chr1 ( 333) 881 178.1 1.4e-44
CCDS5123.1 GJA1 gene_id:2697|Hs108|chr6 ( 382) 847 171.7 1.4e-42
CCDS9290.1 GJB2 gene_id:2706|Hs108|chr13 ( 226) 457 97.2 2.2e-20
CCDS1569.1 GJC2 gene_id:57165|Hs108|chr1 ( 439) 455 97.0 4.9e-20
CCDS383.1 GJB4 gene_id:127534|Hs108|chr1 ( 266) 441 94.2 2.1e-19
CCDS11487.1 GJC1 gene_id:10052|Hs108|chr17 ( 396) 438 93.7 4.3e-19
CCDS384.1 GJB3 gene_id:2707|Hs108|chr1 ( 270) 431 92.3 7.8e-19
CCDS9291.1 GJB6 gene_id:10804|Hs108|chr13 ( 261) 427 91.5 1.3e-18
CCDS14408.1 GJB1 gene_id:2705|Hs108|chrX ( 283) 413 88.9 8.8e-18
CCDS5008.1 GJB7 gene_id:375519|Hs108|chr6 ( 223) 407 87.7 1.6e-17
CCDS382.1 GJB5 gene_id:2709|Hs108|chr1 ( 273) 398 86.0 6.2e-17
CCDS10040.1 GJD2 gene_id:57369|Hs108|chr15 ( 321) 399 86.2 6.2e-17
CCDS58547.1 GJD3 gene_id:125111|Hs108|chr17 ( 294) 362 79.2 7.7e-15
CCDS7191.1 GJD4 gene_id:219770|Hs108|chr10 ( 370) 300 67.4 3.4e-11
CCDS34697.1 GJC3 gene_id:349149|Hs108|chr7 ( 279) 298 67.0 3.5e-11
>>CCDS5025.1 GJA10 gene_id:84694|Hs108|chr6 (543 aa)
initn: 3781 init1: 3781 opt: 3781 Z-score: 3898.8 bits: 731.2 E(32554): 7.6e-211
Smith-Waterman score: 3781; 100.0% identity (100.0% similar) in 543 aa overlap (1-543:1-543)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 TLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 TLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHSSFGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 TMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHSSFGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 QNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLHSHCRDSEGSMRESGVWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 QNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLHSHCRDSEGSMRESGVWI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 DRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHWENSPSPLPSVTGHRTSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 DRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHWENSPSPLPSVTGHRTSM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 VRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGGGDYLWRDKIIHSIHSVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 VRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGGGDYLWRDKIIHSIHSVK
490 500 510 520 530 540
pF1KE0 FNS
:::
CCDS50 FNS
>>CCDS432.1 GJA9 gene_id:81025|Hs108|chr1 (515 aa)
initn: 1190 init1: 1190 opt: 1213 Z-score: 1253.1 bits: 241.5 E(32554): 1.8e-63
Smith-Waterman score: 1219; 47.7% identity (70.1% similar) in 461 aa overlap (1-414:1-453)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
:::::::: ::::: :::..:::::::::::::::: :::::::.::::.: :::.:::
CCDS43 MGDWNLLGDTLEEVHIHSTMIGKIWLTILFIFRMLVLGVAAEDVWNDEQSGFICNTEQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
: :.:::.::::::::.::::.:::::::::::::::::::..:..::: :..::...:.
CCDS43 CRNVCYDQAFPISLIRYWVLQVIFVSSPSLVYMGHALYRLRVLEEERQRMKAQLRVELEE
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 PDLDL-EEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILY
.... ....:...:: .::..: ..:.::.: :: :::.::.::::.:::::::::.::
CCDS43 VEFEMPRDRRRLEQELCQLEKRK-LNKAPLRGTLLCTYVIHIFTRSVVEVGFMIGQYLLY
130 140 150 160 170
180 190 200 210 220 230
pF1KE0 GFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIM
::...::.:: :::: .:::::::::::::.:::.:::.:::.::::::::::..::
CCDS43 GFHLEPLFKCHGHPCPNIIDCFVSRPTEKTIFLLFMQSIATISLFLNILEIFHLGFKKIK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 RTLYKKSSSEGIEDETGPPFHLKK--YSVAQ-QCMICSSLPERISPLQAN--NQQQVIRV
: :. : . . ..: :: .: .::. : .:: . : . : ..:. .
CCDS43 RGLWGKYKLKKEHNE----FHANKAKQNVAKYQSTSANSLKRLPSAPDYNLLVEKQTHTA
240 250 260 270 280 290
300 310 320
pF1KE0 NVPK--SKTMWQIPQPRQLEVDP------------------------------SNGKKDW
:. :....: :.: . :. ::..::
CCDS43 VYPSLNSSSVFQ-PNPDNHSVNDEKCILDEQETVLSNEISTLSTSCSHFQHISSNNNKDT
300 310 320 330 340 350
330 340 350 360 370
pF1KE0 SE---KDQHSGQLHVHSPCPWAGSAGNQHL-GQQS-DHSSFGLQNTMSQSWLGTTTAPRN
. :. ...:: . : : . :..: .. .:.: :: . . : :
CCDS43 HKIFGKELNGNQLMEKRETEGKDSKRNYYSRGHRSIPGVAIDGENNMRQSPQTVFSLPAN
360 370 380 390 400 410
380 390 400 410 420 430
pF1KE0 C---PSFAVGTWEQSQDPEPSGEPLT-DLHSHCRDSEGSMRESGVWIDRSRPGSRKASFL
: : . .:: .: . : : : .:... : .:..:
CCDS43 CDWKPRWLRATWGSSTEHENRGSPPKGNLKGQFR--KGTVRTLPPSQGDSQSLDIPNTAD
420 430 440 450 460 470
440 450 460 470 480 490
pF1KE0 SRLLSEKRHLHSDSGSSGSRNSSCLDFPHWENSPSPLPSVTGHRTSMVRQAALPIMELSQ
CCDS43 SLGGLSFEPGLVRTCNNPVCPPNHVVSLTNNLIGRRVPTDLQI
480 490 500 510
>>CCDS30834.1 GJA8 gene_id:2703|Hs108|chr1 (433 aa)
initn: 973 init1: 557 opt: 955 Z-score: 988.4 bits: 192.3 E(32554): 9.8e-49
Smith-Waterman score: 963; 38.2% identity (66.2% similar) in 456 aa overlap (1-439:1-429)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..::.:::::. :::..:..:::.:::::.:.: .::: :: :::: :.:::.:::
CCDS30 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.:::.::::: ::.:::::::::.:::.:.:::.. .: :: ..:. .: : .
CCDS30 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 ---PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYI
:: : . .. .: .: :.: :::::. ::. ....::::..:.:.
CCDS30 NGGPD-----QGSV----KKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYF
130 140 150 160 170
180 190 200 210 220 230
pF1KE0 LYGFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRK
::::.. :::.:.. ::::.::::::::::::::.::: :.:..::.::..:. :::..
CCDS30 LYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 IMRTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVP
: :. :. .:. : . . .:.: ::. .. . : ...... :
CCDS30 I-RSALKRP----VEQPLGEIPEKSLHSIA-----VSSI-QKAKGYQLLEEEKIVSHYFP
240 250 260 270 280
300 310 320 330 340
pF1KE0 KSKT-MWQI-PQP----RQLEVDPSNGK-KDWSEKDQHS-------GQLHVHSPCPWAGS
... : . : : :.: :.: : :. :.. : .:.. : :
CCDS30 LTEVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEE
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE0 AGNQHLGQQSDHSSFGLQNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLH
... ..:...... . .. ...:.. . :. .... ::..: ..
CCDS30 GAEPEVGEKKEEA-----ERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQG
350 360 370 380 390
410 420 430 440 450 460
pF1KE0 SHCRDSEGSMRESGVWIDRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHW
. . . : . : .:: :: .. :: :.
CCDS30 LPAEKTPSLCPE--LTTDDARPLSRLSKASSRARSDDLTV
400 410 420 430
470 480 490 500 510 520
pF1KE0 ENSPSPLPSVTGHRTSMVRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGG
>>CCDS9289.1 GJA3 gene_id:2700|Hs108|chr13 (435 aa)
initn: 945 init1: 551 opt: 955 Z-score: 988.4 bits: 192.3 E(32554): 9.9e-49
Smith-Waterman score: 955; 52.9% identity (79.7% similar) in 261 aa overlap (1-258:1-253)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..:: .::... :::..::.:::.:::::.::: .:::::: :::: :.:::.:::
CCDS92 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.::: ::::: ::::.:::::::.:.:.:.::.:. .: :: ..:.. . . . :.
CCDS92 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEE-QLKRES
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
:. : : : : ... :.. . : ::::::..:. ....::::. :::.:::
CCDS92 PS-PKEPPQ--DNPSSR-DDRGRVR---MAGALLRTYVFNIIFKTLFEVGFIAGQYFLYG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
:...:::.: . ::::.::::.:::::::::..:: ..: :::::.:::.::: .:. .
CCDS92 FELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQ
180 190 200 210 220 230
250 260 270 280 290
pF1KE0 TLYKKSSSEGIEDETG---PPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVP
. .. . .. : : ::
CCDS92 GVTSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPP
240 250 260 270 280 290
>>CCDS929.1 GJA5 gene_id:2702|Hs108|chr1 (358 aa)
initn: 917 init1: 558 opt: 916 Z-score: 949.5 bits: 184.8 E(32554): 1.4e-46
Smith-Waterman score: 916; 44.4% identity (69.1% similar) in 324 aa overlap (1-320:1-320)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..::..:::::.:::.:::.:::.::::::::: .:::. : :::. : :.: :::
CCDS92 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.:::.::::: ::.:::::::::.:::::::::.. .: :: . :. ::.
CCDS92 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAE--RAKEVR
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
. . : :: :: . .. :.: :: ::: :: :...::::..:::..::
CCDS92 GSGSYEYPVAEKAELSCWEEGN--GRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
. . :. : . :::. :.:.:::::::..:..:: ..::.::::.. :..::: .:: .
CCDS92 IFLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQ
180 190 200 210 220 230
250 260 270 280 290
pF1KE0 TLYKKSSSEGIEDETGPPFHLKKYSVA----QQCMICSSLPERISPLQANNQQQVIRVNV
. : . . . .:: . . . .::. . . ..:.. : .: :.
CCDS92 RFVKPRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 PKSKTMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHS
.. : : . .. :.:
CCDS92 VTEQVRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDL
300 310 320 330 340 350
>>CCDS30669.1 GJA4 gene_id:2701|Hs108|chr1 (333 aa)
initn: 887 init1: 522 opt: 881 Z-score: 913.9 bits: 178.1 E(32554): 1.4e-44
Smith-Waterman score: 881; 41.8% identity (70.9% similar) in 337 aa overlap (1-331:1-329)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..: .:..:. :::.:::::::.:::::.:.: .:.:.:: :::: : ::: :::
CCDS30 MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPG
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRA-QME
:.:.:::.::::: ::.::::..:::.:.:::.::..: : :. :: :...::: .
CCDS30 CTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQ-KEGELRALPAK
70 80 90 100 110
120 130 140 150 160 170
pF1KE0 NPDLDLEEQQRIDRELRRLE--EQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYI
.:... . ..:.. .. :. :.. ..: :. ::: .: .::::.::. ::.
CCDS30 DPQVE-RALAAVERQMAKISVAEDGRLR---IRGALMGTYVASVLCKSVLEAGFLYGQWR
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 LYGFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRK
:::. :.:.. : . ::: ::::::::::::::..:: .. :::.::.::. :: :
CCDS30 LYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRC
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 IMRTLYKKSSSEG--IEDETGPPFHLKKYSVAQQCMICSSLP-ERISPLQANNQQQVIRV
. : . ...... . .. :. . . . :: : . :....:. .
CCDS30 LSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWA---
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 NVPKSKTMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSD
:. . . . : :. :.::.: :. .. ...
CCDS30 NLTTEERLASSRPPLFLDPPPQNGQKPPSRPSSSASKKQYV
300 310 320 330
360 370 380 390 400 410
pF1KE0 HSSFGLQNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLHSHCRDSEGSMR
>>CCDS5123.1 GJA1 gene_id:2697|Hs108|chr6 (382 aa)
initn: 846 init1: 512 opt: 847 Z-score: 877.9 bits: 171.7 E(32554): 1.4e-42
Smith-Waterman score: 847; 42.5% identity (73.1% similar) in 294 aa overlap (1-291:1-289)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::. :: .:..:...:: ::.::..:::::.:.: .:.:..: :::::: :::.:::
CCDS51 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.::: .:::: .::::::::::: :.:.:..:..: .: :: .... :: ..
CCDS51 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIH-KVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILY
..:.. .: :..... . : :: ..: :::::.. :: .:..::.:.. :. .:
CCDS51 VNVDMHLKQI---EIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY
130 140 150 160 170
180 190 200 210 220 230
pF1KE0 GFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIM
::.. .: : . :::. ::::.:::::::::..:: .. .:: :::.:.:.. .. .
CCDS51 GFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 RTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMI--CSSLPERISPLQANNQQQVIRVNVP
. :..:. . .: : . . .. ::: .::.. . . :
CCDS51 DRV--KGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNN
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 KSKTMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHSS
CCDS51 SSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQP
300 310 320 330 340 350
>>CCDS9290.1 GJB2 gene_id:2706|Hs108|chr13 (226 aa)
initn: 715 init1: 435 opt: 457 Z-score: 479.6 bits: 97.2 E(32554): 2.2e-20
Smith-Waterman score: 715; 47.7% identity (71.9% similar) in 235 aa overlap (3-236:2-216)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::. : :: :..::: .::::::.:::::...: :::..:: :::. :.::: :::
CCDS92 MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPG
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.::: :::: ::.:.::.::::.:.:. :. : : :: :. :........
CCDS92 CKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAY--RRHEKKRKFIKGEIKSEFK-
60 70 80 90 100 110
130 140 150 160 170
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILY-
:.:: . .:: ..: : ::. :. : ..:..:: :..:
CCDS92 ---DIEEI--------------KTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYD
120 130 140 150
180 190 200 210 220 230
pF1KE0 GFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIM
::.:. : ::. ::::.::::::::::::.: .:: ....: .:::. :. .: ::
CCDS92 GFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCS
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE0 RTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKS
CCDS92 GKSKKPV
220
>>CCDS1569.1 GJC2 gene_id:57165|Hs108|chr1 (439 aa)
initn: 786 init1: 420 opt: 455 Z-score: 473.1 bits: 97.0 E(32554): 4.9e-20
Smith-Waterman score: 713; 36.9% identity (64.1% similar) in 309 aa overlap (4-258:6-305)
10 20 30 40 50
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQ
:..: .:::.:.:::.:::.:::.: .::... :..: ...:::. :.:::::
CCDS15 MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 PGCNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRL-RAFEKDRQRK-------
:::.:.::: :.: .::::.::. .:.::..:.:.:..:: :: :..:.:
CCDS15 PGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGP
70 80 90 100 110 120
120 130 140 150
pF1KE0 KSHLRAQMENPDLDLEEQQRIDRE-----LRRLEEQKRIHKVPLKG-----------C--
. ::.. : : . .: : . ::... . : :
CCDS15 RRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTK
130 140 150 160 170 180
160 170 180
pF1KE0 ----------------------------LLRTYVLHILTRSVLEVGFMIGQYILYGFQMH
:.:.:: ....:...::.:..:::.::::...
CCDS15 AVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVR
190 200 210 220 230 240
190 200 210 220 230 240
pF1KE0 PLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMRTLYK
:.. :.. :::..::::::::::::.:.: :. .. . ::::. :. :::.
CCDS15 PFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGL---------
250 260 270 280 290
250 260 270 280 290 300
pF1KE0 KSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKSKTMWQ
:...... . :::
CCDS15 GSAQDAVRGRRGPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLA
300 310 320 330 340 350
>>CCDS383.1 GJB4 gene_id:127534|Hs108|chr1 (266 aa)
initn: 628 init1: 423 opt: 441 Z-score: 462.0 bits: 94.2 E(32554): 2.1e-19
Smith-Waterman score: 647; 38.1% identity (67.2% similar) in 265 aa overlap (3-263:2-241)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
.: .: :.: :...::....:::...::::.:: ::::.::::::. :.:::.:::
CCDS38 MNWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPG
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
: :.:::. ::.: .:.:.::.:.:. :::. . :. :: ..:.::. ::. .
CCDS38 CPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYR-----EERERKH-HLKHGPNA
60 70 80 90 100 110
130 140 150 160 170
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILY-
:.: : .. .: : ::.: .. ......::. . ::
CCDS38 PSL-------YDNLSKK------------RGGLWWTYLLSLIFKAAVDAGFLYIFHRLYK
120 130 140 150
180 190 200 210 220 230
pF1KE0 GFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIM
..: . :. :::..:::..:::::: .: :: . ::: .:::. :.:.: .. :
CCDS38 DYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVGKRCM
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE0 RTL---YKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNV
. . ... . .: ::. :..
CCDS38 EIFGPRHRRPRCRECLPDTCPPYVLSQGGHPEDGNSVLMKAGSAPVDAGGYP
220 230 240 250 260
543 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 14:34:28 2016 done: Thu Nov 3 14:34:28 2016
Total Scan time: 3.480 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]