Result of FASTA (omim) for
pFN21AB8011
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8011, 414 aa
1>>>pF1KB8011 414 - 414 aa - 414 aa
Library: /omim/omim.rfq.tfa
64092750 residues in 91774 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7832+/-0.000411; mu= 14.2750+/- 0.025
mean_var=89.0931+/-17.689, 0's: 0 Z-trim(113.1): 269 B-trim: 399 in 1/51
Lambda= 0.135879
statistics sampled from 22738 (23103) to 22738 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.252), width: 16
Scan time: 3.960
The best scores are: opt bits E(91774)
NP_057457 (OMIM: 133239,605131,614322,616211) WW d ( 414) 2794 558.3 1.4e-158
NP_001278926 (OMIM: 133239,605131,614322,616211) W ( 301) 2001 402.7 6.6e-112
NP_570607 (OMIM: 133239,605131,614322,616211) WW d ( 189) 1171 239.9 4.4e-63
NP_057110 (OMIM: 607849,616108) retinol dehydrogen ( 318) 539 116.2 1.3e-25
NP_689656 (OMIM: 608830,612712) retinol dehydrogen ( 316) 538 116.0 1.5e-25
NP_653284 (OMIM: 616157) dehydrogenase/reductase S ( 377) 518 112.1 2.6e-24
NP_065956 (OMIM: 616796) retinol dehydrogenase 14 ( 336) 517 111.9 2.7e-24
NP_001239579 (OMIM: 607849,616108) retinol dehydro ( 248) 299 69.0 1.6e-11
NP_001257353 (OMIM: 616163) dehydrogenase/reductas ( 317) 275 64.4 4.9e-10
XP_005260627 (OMIM: 606409,613385) E3 ubiquitin-pr ( 692) 257 61.1 1.1e-08
XP_011527381 (OMIM: 606409,613385) E3 ubiquitin-pr ( 692) 257 61.1 1.1e-08
NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-pr ( 752) 257 61.1 1.1e-08
XP_016883580 (OMIM: 606409,613385) E3 ubiquitin-pr ( 752) 257 61.1 1.1e-08
NP_001311127 (OMIM: 606409,613385) E3 ubiquitin-pr ( 862) 257 61.2 1.2e-08
NP_113671 (OMIM: 606409,613385) E3 ubiquitin-prote ( 862) 257 61.2 1.2e-08
XP_016883579 (OMIM: 606409,613385) E3 ubiquitin-pr ( 900) 257 61.2 1.3e-08
XP_016883578 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 257 61.2 1.3e-08
NP_001244066 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 257 61.2 1.3e-08
NP_001311126 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 257 61.2 1.3e-08
XP_024307773 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 257 61.2 1.3e-08
XP_016868486 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 719) 229 55.6 4.9e-07
XP_016868484 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 743) 229 55.7 5e-07
XP_016868485 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 743) 229 55.7 5e-07
XP_024302824 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 898) 229 55.7 5.8e-07
XP_016868483 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 898) 229 55.7 5.8e-07
XP_016868482 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 921) 229 55.7 5.9e-07
XP_005250818 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 921) 229 55.7 5.9e-07
NP_008944 (OMIM: 602307) NEDD4-like E3 ubiquitin-p ( 922) 229 55.7 5.9e-07
XP_005250817 (OMIM: 602307) NEDD4-like E3 ubiquiti ( 922) 229 55.7 5.9e-07
NP_001186776 (OMIM: 605568) E3 ubiquitin-protein l ( 728) 202 50.4 1.9e-05
NP_851994 (OMIM: 605568) E3 ubiquitin-protein liga ( 731) 202 50.4 1.9e-05
NP_001316141 (OMIM: 602278) E3 ubiquitin-protein l ( 753) 174 44.9 0.00089
XP_011519927 (OMIM: 602278) E3 ubiquitin-protein l ( 849) 174 44.9 0.00097
XP_011519928 (OMIM: 602278) E3 ubiquitin-protein l ( 849) 174 44.9 0.00097
XP_011519926 (OMIM: 602278) E3 ubiquitin-protein l ( 875) 174 44.9 0.001
NP_006145 (OMIM: 602278) E3 ubiquitin-protein liga ( 900) 174 44.9 0.001
NP_057329 (OMIM: 612831) estradiol 17-beta-dehydro ( 300) 167 43.2 0.0011
NP_940682 (OMIM: 602278) E3 ubiquitin-protein liga (1247) 174 45.0 0.0013
NP_001271269 (OMIM: 602278) E3 ubiquitin-protein l (1302) 174 45.0 0.0014
NP_001271268 (OMIM: 602278) E3 ubiquitin-protein l (1303) 174 45.0 0.0014
NP_001271267 (OMIM: 602278) E3 ubiquitin-protein l (1319) 174 45.0 0.0014
XP_016881165 (OMIM: 606384,617201) E3 ubiquitin-pr ( 856) 171 44.3 0.0015
NP_065715 (OMIM: 615839) peroxisomal 2,4-dienoyl-C ( 292) 161 42.0 0.0025
NP_078981 (OMIM: 616163) dehydrogenase/reductase S ( 242) 157 41.2 0.0037
NP_001026889 (OMIM: 616163) dehydrogenase/reductas ( 271) 157 41.2 0.004
XP_011508777 (OMIM: 612131) dehydrogenase/reductas ( 319) 156 41.1 0.0052
NP_954674 (OMIM: 612131) dehydrogenase/reductase S ( 319) 156 41.1 0.0052
NP_001135743 (OMIM: 612131) dehydrogenase/reductas ( 319) 156 41.1 0.0052
NP_001135742 (OMIM: 612131) dehydrogenase/reductas ( 319) 156 41.1 0.0052
NP_001291442 (OMIM: 606756) 3-keto-steroid reducta ( 111) 149 39.4 0.0059
>>NP_057457 (OMIM: 133239,605131,614322,616211) WW domai (414 aa)
initn: 2794 init1: 2794 opt: 2794 Z-score: 2968.8 bits: 558.3 E(91774): 1.4e-158
Smith-Waterman score: 2794; 99.8% identity (100.0% similar) in 414 aa overlap (1-414:1-414)
10 20 30 40 50 60
pF1KB8 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVETM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_057 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 TLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 QLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 ILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTV
310 320 330 340 350 360
370 380 390 400 410
pF1KB8 YCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 YCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG
370 380 390 400 410
>>NP_001278926 (OMIM: 133239,605131,614322,616211) WW do (301 aa)
initn: 2001 init1: 2001 opt: 2001 Z-score: 2130.6 bits: 402.7 E(91774): 6.6e-112
Smith-Waterman score: 2001; 99.7% identity (100.0% similar) in 301 aa overlap (114-414:1-301)
90 100 110 120 130 140
pF1KB8 TYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKS
::::::::::::::::::::::::::::::
NP_001 MEILQGRDFTGKVVVVTGANSGIGFETAKS
10 20 30
150 160 170 180 190 200
pF1KB8 FALHGAHVILACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSVQHFAEAFKAKNVP
:::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_001 FALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVP
40 50 60 70 80 90
210 220 230 240 250 260
pF1KB8 LHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESH
100 110 120 130 140 150
270 280 290 300 310 320
pF1KB8 RFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHP
160 170 180 190 200 210
330 340 350 360 370 380
pF1KB8 GNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCM
220 230 240 250 260 270
390 400 410
pF1KB8 PSPEAQSEETARTLWALSERLIQERLGSQSG
:::::::::::::::::::::::::::::::
NP_001 PSPEAQSEETARTLWALSERLIQERLGSQSG
280 290 300
>>NP_570607 (OMIM: 133239,605131,614322,616211) WW domai (189 aa)
initn: 1171 init1: 1171 opt: 1171 Z-score: 1254.1 bits: 239.9 E(91774): 4.4e-63
Smith-Waterman score: 1171; 100.0% identity (100.0% similar) in 172 aa overlap (1-172:1-172)
10 20 30 40 50 60
pF1KB8 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_570 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_570 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVETM
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_570 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWKTKYHPPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 TLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLV
NP_570 EKCRIKIFH
>>NP_057110 (OMIM: 607849,616108) retinol dehydrogenase (318 aa)
initn: 656 init1: 390 opt: 539 Z-score: 581.4 bits: 116.2 E(91774): 1.3e-25
Smith-Waterman score: 661; 42.4% identity (67.4% similar) in 288 aa overlap (124-405:41-313)
100 110 120 130 140 150
pF1KB8 VDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVIL
::::::::::.::: :::: .: .::.: :
NP_057 LLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYL
20 30 40 50 60 70
160 170 180 190 200 210
pF1KB8 ACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAAT
:::.. .. ....: . .: . :::. .:.. ::..: :.. ::::. ::..
NP_057 ACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGV
80 90 100 110 120 130
220 230 240 250 260 270
pF1KB8 FALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLG
. :.: : ::.: . ::::::: :..:: . : .:::.:.. ::: .:. ::
NP_057 MMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHH-------LG
140 150 160 170 180
280 290 300 310 320 330
pF1KB8 KLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHR
.. : :. : : : ::: .::: ::::..:: :::. :::. .::::... ...
NP_057 RIHFHNLQGEKF-YNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRH
190 200 210 220 230 240
340 350 360 370 380
pF1KB8 S------WWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPE
: ::.... : :. :::: :...:: . :: :.: .:..: : .
NP_057 SSFMRWMWWLFSF-------FIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQ
250 260 270 280 290
390 400 410
pF1KB8 AQSEETARTLWALSERLIQERLGSQSG
:..: :: :: .: :.
NP_057 ARNETIARRLWDVSCDLLGLPID
300 310
>>NP_689656 (OMIM: 608830,612712) retinol dehydrogenase (316 aa)
initn: 694 init1: 408 opt: 538 Z-score: 580.3 bits: 116.0 E(91774): 1.5e-25
Smith-Waterman score: 712; 41.6% identity (68.8% similar) in 308 aa overlap (101-408:20-314)
80 90 100 110 120 130
pF1KB8 GQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVT
:. :. . :.. .. .. :::::.:
NP_689 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNV----QLPGKVVVIT
10 20 30 40
140 150 160 170 180 190
pF1KB8 GANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSV
:::.::: :::. .: .::.: .:::.. .. :.:.: . ....: . :::. .:.
NP_689 GANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSI
50 60 70 80 90 100
200 210 220 230 240 250
pF1KB8 QHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRS
. :::.: :.. ::.:. ::... :.: : ::.:: . ::::::: :. :: . : :
NP_689 RAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVS
110 120 130 140 150 160
260 270 280 290 300 310
pF1KB8 APARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRR
:::::. ::: .:. .::. : :. : : .:: .::: :.::. :: .:
NP_689 APARVVNVSSVAHH-------IGKIPFHDLQSEKR-YSRGFAYCHSKLANVLFTRELAKR
170 180 190 200 210
320 330 340 350 360 370
pF1KB8 LSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEG
:. :::. ::::: .. :.. : . ::. : ::.:. ..:: :...:: . ::
NP_689 LQGTGVTTYAVHPG-VVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEP
220 230 240 250 260 270
380 390 400 410
pF1KB8 LGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG
:.: ::..: : ::.:....::. :: .: .:. :
NP_689 LSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGIRWE
280 290 300 310
>>NP_653284 (OMIM: 616157) dehydrogenase/reductase SDR f (377 aa)
initn: 563 init1: 216 opt: 518 Z-score: 558.1 bits: 112.1 E(91774): 2.6e-24
Smith-Waterman score: 547; 38.7% identity (61.7% similar) in 287 aa overlap (121-404:33-310)
100 110 120 130 140 150
pF1KB8 AFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAH
.. :...:::::::::: :: .: .::.
NP_653 ALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGAR
10 20 30 40 50 60
160 170 180 190 200 210
pF1KB8 VILACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSVQHFAEAFKAKNVPLHVLVCN
:.::::.. :. :. . .: . .: :.:::: : ::. :: :: ... : .:. :
NP_653 VVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILIHN
70 80 90 100 110 120
220 230 240 250 260 270
pF1KB8 AATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDIND
:. . . :..... ..:::.: : :..:: : ::.::.::.: .:
NP_653 AGISSC--GRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAH-------
130 140 150 160 170
280 290 300 310 320
pF1KB8 SLGKLDFSRLS-PTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPG--NMM
:.:::.::. :. . . :: .:: :.::. :: .: ::: :.::: :
NP_653 CRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSE
180 190 200 210 220 230
330 340 350 360 370 380
pF1KB8 YSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPE
: :. :: :: .. . :: : .::: .: :.: :: :: :
NP_653 LFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPA
240 250 260 270 280 290
390 400 410
pF1KB8 AQSEETARTLWALSERLIQERLGSQSG
:.....:. :: :.::
NP_653 ARDDRAAHRLWEASKRLAGLGPGEDAEPDEDPQSEDSEAPSSLSTPHPEEPTVSQPYPSP
300 310 320 330 340 350
>>NP_065956 (OMIM: 616796) retinol dehydrogenase 14 [Hom (336 aa)
initn: 666 init1: 259 opt: 517 Z-score: 557.7 bits: 111.9 E(91774): 2.7e-24
Smith-Waterman score: 632; 40.5% identity (65.9% similar) in 299 aa overlap (124-405:43-332)
100 110 120 130 140 150
pF1KB8 VDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVIL
::.:..::::::.: :: . ::.::.
NP_065 LGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARVIM
20 30 40 50 60 70
160 170 180 190 200
pF1KB8 ACRNMARASEAVSRILEEWHKA-------------KVETMTLDLALLRSVQHFAEAFKAK
.::. ::: ::.... .: ..: .. . :::: ::::. : . . .
NP_065 GCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQE
80 90 100 110 120 130
210 220 230 240 250 260
pF1KB8 NVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSS
. : ::. ::. : :. :.::.: : ::::::: :..:: .: :::.:..::::
NP_065 EPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSS
140 150 160 170 180 190
270 280 290 300 310 320
pF1KB8 ESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNA
. ... ::: :. :. ....: . :.:::: ::::. :: ::: .:: :.
NP_065 KLYKYGDIN-------FDDLN-SEQSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNV
200 210 220 230 240
330 340 350 360 370
pF1KB8 VHPGNMMYSNIHRSWWVYTL---LFTLAR-PFTKSMQQGAATTVYCAAVPELEGLGGMYF
.::: .. .:. : . : ::.:. : :. .:: :..: :. ::.::..: ::
NP_065 LHPG-IVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSGRYF
250 260 270 280 290 300
380 390 400 410
pF1KB8 NNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG
..: . :.:..: .:: :: .:: ..
NP_065 GDCKEEELLPKAMDESVARKLWDISEVMVGLLK
310 320 330
>>NP_001239579 (OMIM: 607849,616108) retinol dehydrogena (248 aa)
initn: 482 init1: 299 opt: 299 Z-score: 328.6 bits: 69.0 E(91774): 1.6e-11
Smith-Waterman score: 326; 29.9% identity (49.3% similar) in 288 aa overlap (124-405:41-243)
100 110 120 130 140 150
pF1KB8 VDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVIL
::::::::::.::: :::: .: .::.: :
NP_001 LLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYL
20 30 40 50 60 70
160 170 180 190 200 210
pF1KB8 ACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAAT
:::.. .. ....: . .: . :::. .:.. ::..: :.. ::::. ::..
NP_001 ACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGV
80 90 100 110 120 130
220 230 240 250 260 270
pF1KB8 FALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLG
. :.: : ::.: . :::::
NP_001 MMCPYSKTADGFEMHIGVNHLGS-------------------------------------
140 150
280 290 300 310 320 330
pF1KB8 KLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHR
:::. .::::... ...
NP_001 -----------------------------------------GVTTYSVHPGTVQSELVRH
160 170
340 350 360 370 380
pF1KB8 S------WWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPE
: ::.... : :. :::: :...:: . :: :.: .:..: : .
NP_001 SSFMRWMWWLFSF-------FIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQ
180 190 200 210 220
390 400 410
pF1KB8 AQSEETARTLWALSERLIQERLGSQSG
:..: :: :: .: :.
NP_001 ARNETIARRLWDVSCDLLGLPID
230 240
>>NP_001257353 (OMIM: 616163) dehydrogenase/reductase SD (317 aa)
initn: 257 init1: 143 opt: 275 Z-score: 301.7 bits: 64.4 E(91774): 4.9e-10
Smith-Waterman score: 285; 32.3% identity (62.7% similar) in 201 aa overlap (124-324:40-230)
100 110 120 130 140 150
pF1KB8 VDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVIL
:.: .:::.::::: :: .: .:. : :
NP_001 FAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHL
10 20 30 40 50 60
160 170 180 190 200 210
pF1KB8 ACRNMARASEAVSRILEEWHKAKVETMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAAT
.::..: : .: ..:..: . .. .::. ... .:.: :: .. ::::. ::.
NP_001 VCRDQAPAEDARGEIIRESGNQNIFLHIVDLSDPKQIWKFVENFKQEH-KLHVLINNAGC
70 80 90 100 110 120
220 230 240 250 260 270
pF1KB8 FALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLG
.. ::.:::: .: .: :: . :. : :: . :::.::: . .
NP_001 MVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGML-------VQ
130 140 150 160 170 180
280 290 300 310 320 330
pF1KB8 KLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHR
::. . :. .. . . ..: ..: ..... : . : .. ...:::
NP_001 KLNTNDLQSERTPFDGTMVYAQNKRQQVVLT-ERWAQGHP-AIHFSSMHPGWADTPGVRQ
190 200 210 220 230
340 350 360 370 380 390
pF1KB8 SWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEET
NP_001 AMPGFHARFGDRLRSEAQGADTMLWLALSSAAAAQPSGRFFQDRKPVSTHLPLATASSSP
240 250 260 270 280 290
>>XP_005260627 (OMIM: 606409,613385) E3 ubiquitin-protei (692 aa)
initn: 497 init1: 150 opt: 257 Z-score: 277.8 bits: 61.1 E(91774): 1.1e-08
Smith-Waterman score: 257; 43.5% identity (67.1% similar) in 85 aa overlap (13-97:224-307)
10 20 30 40
pF1KB8 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKT
: ::::::.:: ..: ::..::. . :
XP_005 SQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRIT
200 210 220 230 240 250
50 60 70 80 90 100
pF1KB8 QWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPT
::: :.. . . :: :::.. .: .:::: . :::.::: . .. ::
XP_005 QWEDPRS-QGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIA
260 270 280 290 300 310
110 120 130 140 150 160
pF1KB8 TRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARAS
XP_005 YVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPG
320 330 340 350 360 370
>--
initn: 370 init1: 143 opt: 232 Z-score: 251.4 bits: 56.2 E(91774): 3.1e-07
Smith-Waterman score: 232; 33.3% identity (64.0% similar) in 111 aa overlap (14-124:113-210)
10 20 30 40
pF1KB8 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQ
.. ::::::.:. . : :::..:.:..:
XP_005 NTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTT
90 100 110 120 130 140
50 60 70 80 90 100
pF1KB8 WEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTT
:..:. :: :::...:. :....:::... ::. : : .: .
XP_005 WDRPEP---------LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE-SVRNYEQWQLQ
150 160 170 180 190
110 120 130 140 150 160
pF1KB8 RQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASE
:.. .: ::. .. : . :
XP_005 RSQLQG---AMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHN
200 210 220 230 240
414 residues in 1 query sequences
64092750 residues in 91774 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Jul 16 15:40:44 2019 done: Tue Jul 16 15:40:45 2019
Total Scan time: 3.960 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]