Result of FASTA (omim) for
pFN21AE0524
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0524, 239 aa
1>>>pF1KE0524 239 - 239 aa - 239 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0307+/-0.000363; mu= 16.5151+/- 0.022
mean_var=78.5869+/-16.376, 0's: 0 Z-trim(115.4): 21 B-trim: 1592 in 3/55
Lambda= 0.144677
statistics sampled from 25755 (25777) to 25755 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.671), E-opt: 0.2 (0.302), width: 16
Scan time: 6.800
The best scores are: opt bits E(85289)
NP_001129223 (OMIM: 610305) derlin-3 isoform 1 [Ho ( 239) 1609 345.0 6.8e-95
NP_001002862 (OMIM: 610305) derlin-3 isoform 2 [Ho ( 235) 1402 301.8 6.8e-82
XP_011528808 (OMIM: 610305) PREDICTED: derlin-3 is ( 233) 1391 299.5 3.3e-81
NP_940842 (OMIM: 610305) derlin-3 isoform 3 [Homo ( 205) 1386 298.4 6.2e-81
XP_011528807 (OMIM: 610305) PREDICTED: derlin-3 is ( 234) 1383 297.8 1.1e-80
XP_016884570 (OMIM: 610305) PREDICTED: derlin-3 is ( 249) 1176 254.6 1.1e-67
NP_057125 (OMIM: 610304) derlin-2 isoform a [Homo ( 239) 1158 250.9 1.5e-66
NP_001291706 (OMIM: 610304) derlin-2 isoform b [Ho ( 238) 1139 246.9 2.3e-65
XP_016884571 (OMIM: 610305) PREDICTED: derlin-3 is ( 165) 1108 240.3 1.6e-63
XP_016884567 (OMIM: 610305) PREDICTED: derlin-3 is ( 299) 742 164.1 2.4e-40
XP_016884568 (OMIM: 610305) PREDICTED: derlin-3 is ( 298) 723 160.2 3.7e-39
NP_077271 (OMIM: 608813) derlin-1 isoform a [Homo ( 251) 493 112.1 9.3e-25
NP_001128143 (OMIM: 608813) derlin-1 isoform b [Ho ( 231) 415 95.8 7e-20
XP_016884569 (OMIM: 610305) PREDICTED: derlin-3 is ( 279) 409 94.6 1.9e-19
NP_001291708 (OMIM: 610304) derlin-2 isoform c [Ho ( 74) 280 67.1 9.2e-12
NP_001317530 (OMIM: 608813) derlin-1 isoform c [Ho ( 151) 256 62.4 5e-10
XP_006716720 (OMIM: 608813) PREDICTED: derlin-1 is ( 151) 256 62.4 5e-10
>>NP_001129223 (OMIM: 610305) derlin-3 isoform 1 [Homo s (239 aa)
initn: 1609 init1: 1609 opt: 1609 Z-score: 1824.6 bits: 345.0 E(85289): 6.8e-95
Smith-Waterman score: 1609; 100.0% identity (100.0% similar) in 239 aa overlap (1-239:1-239)
10 20 30 40 50 60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
130 140 150 160 170 180
190 200 210 220 230
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
190 200 210 220 230
>>NP_001002862 (OMIM: 610305) derlin-3 isoform 2 [Homo s (235 aa)
initn: 1453 init1: 1389 opt: 1402 Z-score: 1591.2 bits: 301.8 E(85289): 6.8e-82
Smith-Waterman score: 1402; 92.6% identity (94.3% similar) in 229 aa overlap (1-229:1-228)
10 20 30 40 50 60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
130 140 150 160 170 180
190 200 210 220 230
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
::::::::::::::::::::::::: : . ::: . . . : ::
NP_001 IYYFLEDVFPNQPGGKRLLQTPGFLKLLLD-APAEDPNYLPLPEEQPGPHLPPPQQ
190 200 210 220 230
>>XP_011528808 (OMIM: 610305) PREDICTED: derlin-3 isofor (233 aa)
initn: 1386 init1: 1386 opt: 1391 Z-score: 1578.9 bits: 299.5 E(85289): 3.3e-81
Smith-Waterman score: 1391; 96.7% identity (98.1% similar) in 213 aa overlap (1-213:1-213)
10 20 30 40 50 60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
130 140 150 160 170 180
190 200 210 220 230
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
::::::::::::::::::::::::: ... :
XP_011 IYYFLEDVFPNQPGGKRLLQTPGFLLATAQQCPHRTGPSAGDFRAARPQLAVA
190 200 210 220 230
>>NP_940842 (OMIM: 610305) derlin-3 isoform 3 [Homo sapi (205 aa)
initn: 1386 init1: 1386 opt: 1386 Z-score: 1574.0 bits: 298.4 E(85289): 6.2e-81
Smith-Waterman score: 1386; 100.0% identity (100.0% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
130 140 150 160 170 180
190 200 210 220 230
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
:::::::::::::::::::::::::
NP_940 IYYFLEDVFPNQPGGKRLLQTPGFL
190 200
>>XP_011528807 (OMIM: 610305) PREDICTED: derlin-3 isofor (234 aa)
initn: 1432 init1: 1186 opt: 1383 Z-score: 1569.8 bits: 297.8 E(85289): 1.1e-80
Smith-Waterman score: 1383; 92.1% identity (93.9% similar) in 229 aa overlap (1-229:1-227)
10 20 30 40 50 60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_011 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAV-LELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
120 130 140 150 160 170
190 200 210 220 230
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
::::::::::::::::::::::::: : . ::: . . . : ::
XP_011 IYYFLEDVFPNQPGGKRLLQTPGFLKLLLD-APAEDPNYLPLPEEQPGPHLPPPQQ
180 190 200 210 220 230
>>XP_016884570 (OMIM: 610305) PREDICTED: derlin-3 isofor (249 aa)
initn: 1176 init1: 1176 opt: 1176 Z-score: 1336.0 bits: 254.6 E(85289): 1.1e-67
Smith-Waterman score: 1176; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175)
10 20 30 40 50 60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGEPPGT
130 140 150 160 170 180
190 200 210 220 230
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
XP_016 SSPPQAGHSPQDTLLMPWGPSPILAGVLLTPGSIPIFLPSQLLCSYSPSSQPAHIICIVR
190 200 210 220 230 240
>>NP_057125 (OMIM: 610304) derlin-2 isoform a [Homo sapi (239 aa)
initn: 1158 init1: 1158 opt: 1158 Z-score: 1315.9 bits: 250.9 E(85289): 1.5e-66
Smith-Waterman score: 1158; 79.0% identity (95.1% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
::.:.: :.::.: :.::::.:::::::::::::..::::::::.:.:..::.:::.::
NP_057 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
::::::.::.:.:::.:..:::::::::::::::::::::::::: ::::.::. :: ::
NP_057 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
:::. :::::::::.: ::.::::::.::::::::.::::::::::::.::::::::::
NP_057 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
130 140 150 160 170 180
190 200 210 220 230
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
::.:::::::::::: :.:.::..:
NP_057 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
190 200 210 220 230
>>NP_001291706 (OMIM: 610304) derlin-2 isoform b [Homo s (238 aa)
initn: 1016 init1: 1016 opt: 1139 Z-score: 1294.5 bits: 246.9 E(85289): 2.3e-65
Smith-Waterman score: 1139; 78.5% identity (94.6% similar) in 205 aa overlap (1-205:1-204)
10 20 30 40 50 60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
::.:.: :.::.: :.::::.::::::::: :::..::::::::.:.:..::.:::.::
NP_001 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAV-LELITPFQLYFNPELIFKHFQIWRLITN
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
::::::.::.:.:::.:..:::::::::::::::::::::::::: ::::.::. :: ::
NP_001 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
:::. :::::::::.: ::.::::::.::::::::.::::::::::::.::::::::::
NP_001 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
120 130 140 150 160 170
190 200 210 220 230
pF1KE0 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
::.:::::::::::: :.:.::..:
NP_001 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
180 190 200 210 220 230
>>XP_016884571 (OMIM: 610305) PREDICTED: derlin-3 isofor (165 aa)
initn: 1108 init1: 1108 opt: 1108 Z-score: 1261.6 bits: 240.3 E(85289): 1.6e-63
Smith-Waterman score: 1108; 100.0% identity (100.0% similar) in 165 aa overlap (75-239:1-165)
50 60 70 80 90 100
pF1KE0 PHLVFRKFQVWRLVTNFLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFG
::::::::::::::::::::::::::::::
XP_016 MLFVFRYCRMLEEGSFRGRTADFVFMFLFG
10 20 30
110 120 130 140 150 160
pF1KE0 GVLMTLLGLLGSLFFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVLMTLLGLLGSLFFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLL
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE0 LGNSILVDLLGIAVGHIYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGNSILVDLLGIAVGHIYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQ
100 110 120 130 140 150
230
pF1KE0 SQGGPGTAGELAAPS
:::::::::::::::
XP_016 SQGGPGTAGELAAPS
160
>>XP_016884567 (OMIM: 610305) PREDICTED: derlin-3 isofor (299 aa)
initn: 792 init1: 742 opt: 742 Z-score: 845.4 bits: 164.1 E(85289): 2.4e-40
Smith-Waterman score: 742; 99.1% identity (100.0% similar) in 110 aa overlap (1-110:1-110)
10 20 30 40 50 60
pF1KE0 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
:::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTVSFPQALEPRA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
XP_016 RAPRRPACVGPGANTAMPERDTVAVSSLVCVEGPLCAQLQGSGLDLQCCMQNTKPCTKEP
130 140 150 160 170 180
239 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 01:56:10 2016 done: Thu Nov 3 01:56:11 2016
Total Scan time: 6.800 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]