Result of FASTA (ccds) for
pFN21AE0435
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0435, 257 aa
1>>>pF1KE0435 257 - 257 aa - 257 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3262+/-0.000943; mu= 14.0779+/- 0.056
mean_var=62.4440+/-13.170, 0's: 0 Z-trim(104.4): 29 B-trim: 0 in 0/49
Lambda= 0.162304
statistics sampled from 7879 (7893) to 7879 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.242), width: 16
Scan time: 2.220
The best scores are: opt bits E(32554)
CCDS10184.1 APH1B gene_id:83464|Hs108|chr15 ( 257) 1679 401.8 2.4e-112
CCDS41391.1 APH1A gene_id:51107|Hs108|chr1 ( 247) 999 242.6 2e-64
CCDS41390.1 APH1A gene_id:51107|Hs108|chr1 ( 265) 994 241.4 4.7e-64
CCDS45276.1 APH1B gene_id:83464|Hs108|chr15 ( 216) 755 185.4 2.7e-47
CCDS58025.1 APH1A gene_id:51107|Hs108|chr1 ( 195) 517 129.7 1.5e-30
>>CCDS10184.1 APH1B gene_id:83464|Hs108|chr15 (257 aa)
initn: 1679 init1: 1679 opt: 1679 Z-score: 2130.6 bits: 401.8 E(32554): 2.4e-112
Smith-Waterman score: 1679; 99.6% identity (100.0% similar) in 257 aa overlap (1-257:1-257)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
CCDS10 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
190 200 210 220 230 240
250
pF1KE0 CLLCQDKNFLLYNQRSR
:::::::::::::::::
CCDS10 CLLCQDKNFLLYNQRSR
250
>>CCDS41391.1 APH1A gene_id:51107|Hs108|chr1 (247 aa)
initn: 972 init1: 536 opt: 999 Z-score: 1270.3 bits: 242.6 E(32554): 2e-64
Smith-Waterman score: 999; 58.7% identity (82.6% similar) in 247 aa overlap (1-246:1-247)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
: :::::::.:.:::::.::...:.: .:::.:.:.:::::::::::..:.:::. .
CCDS41 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAP-SMRLLAYV
: .:. : :::::: ::: ..:.::::::::::::.::: :.. .: :.: .:::
CCDS41 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFD
:::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.::::
CCDS41 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK
.::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::..
CCDS41 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
190 200 210 220 230 240
240 250
pF1KE0 LCLLCQDKNFLLYNQRSR
:::.:
CCDS41 RSLLCKD
>>CCDS41390.1 APH1A gene_id:51107|Hs108|chr1 (265 aa)
initn: 963 init1: 527 opt: 994 Z-score: 1263.5 bits: 241.4 E(32554): 4.7e-64
Smith-Waterman score: 994; 56.8% identity (81.3% similar) in 257 aa overlap (1-253:1-257)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
: :::::::.:.:::::.::...:.: .:::.:.:.:::::::::::..:.:::. .
CCDS41 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAP-SMRLLAYV
: .:. : :::::: ::: ..:.::::::::::::.::: :.. .: :.: .:::
CCDS41 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFD
:::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.::::
CCDS41 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK
.::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::..
CCDS41 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
190 200 210 220 230 240
240 250
pF1KE0 LCLLC---QDKNFLLYNQRSR
::: .:. ..:.
CCDS41 RSLLCRRQEDSRVMVYSALRIPPED
250 260
>>CCDS45276.1 APH1B gene_id:83464|Hs108|chr15 (216 aa)
initn: 777 init1: 755 opt: 755 Z-score: 962.4 bits: 185.4 E(32554): 2.7e-47
Smith-Waterman score: 1313; 83.7% identity (84.0% similar) in 257 aa overlap (1-257:1-216)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
CCDS45 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAY--
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
:::::::::::::::::::::
CCDS45 ---------------------------------------AFMTLVIILLHVFWGIVFFDG
120 130
190 200 210 220 230 240
pF1KE0 CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
140 150 160 170 180 190
250
pF1KE0 CLLCQDKNFLLYNQRSR
:::::::::::::::::
CCDS45 CLLCQDKNFLLYNQRSR
200 210
>>CCDS58025.1 APH1A gene_id:51107|Hs108|chr1 (195 aa)
initn: 683 init1: 509 opt: 517 Z-score: 661.9 bits: 129.7 E(32554): 1.5e-30
Smith-Waterman score: 560; 40.2% identity (59.8% similar) in 256 aa overlap (1-253:1-187)
10 20 30 40 50 60
pF1KE0 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
: :::::::.:.:::::.::...:.: .:::.:.:.:: :.:
CCDS58 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGRC--------SAL---------
10 20 30 40
70 80 90 100 110 120
pF1KE0 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
:: . : .:
CCDS58 -----PTTSCL-----------------------------------------------IS
50
130 140 150 160 170 180
pF1KE0 GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.::::.
CCDS58 GLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDA
60 70 80 90 100 110
190 200 210 220 230 240
pF1KE0 CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::..
CCDS58 CERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQR
120 130 140 150 160 170
250
pF1KE0 CLLC---QDKNFLLYNQRSR
::: .:. ..:.
CCDS58 SLLCRRQEDSRVMVYSALRIPPED
180 190
257 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 09:19:27 2016 done: Thu Nov 3 09:19:27 2016
Total Scan time: 2.220 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]