Result of FASTA (omim) for
pFN21AB5718
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5718, 724 aa
1>>>pF1KB5718 724 - 724 aa - 724 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.5937+/-0.000373; mu= -10.1522+/- 0.023
mean_var=295.2716+/-61.997, 0's: 0 Z-trim(122.2): 36 B-trim: 1059 in 2/54
Lambda= 0.074639
statistics sampled from 39822 (39861) to 39822 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.467), width: 16
Scan time: 9.980
The best scores are: opt bits E(85289)
NP_997006 (OMIM: 604439) GRB2-associated-binding p ( 724) 4965 548.4 3.6e-155
XP_016863457 (OMIM: 604439) PREDICTED: GRB2-associ ( 711) 4804 531.1 5.8e-150
XP_016863460 (OMIM: 604439) PREDICTED: GRB2-associ ( 621) 4257 472.2 2.8e-132
NP_002030 (OMIM: 604439) GRB2-associated-binding p ( 694) 3711 413.4 1.5e-114
XP_016863458 (OMIM: 604439) PREDICTED: GRB2-associ ( 648) 3631 404.8 5.7e-112
XP_006714230 (OMIM: 604439) PREDICTED: GRB2-associ ( 648) 3631 404.8 5.7e-112
XP_016863459 (OMIM: 604439) PREDICTED: GRB2-associ ( 648) 3631 404.8 5.7e-112
XP_006714231 (OMIM: 604439) PREDICTED: GRB2-associ ( 648) 3631 404.8 5.7e-112
XP_016863456 (OMIM: 604439) PREDICTED: GRB2-associ ( 734) 3631 404.8 6.3e-112
XP_016863455 (OMIM: 604439) PREDICTED: GRB2-associ ( 738) 3631 404.8 6.4e-112
NP_536739 (OMIM: 606203) GRB2-associated-binding p ( 676) 1166 139.3 4.7e-32
NP_036428 (OMIM: 606203) GRB2-associated-binding p ( 638) 921 113.0 3.9e-24
XP_006718816 (OMIM: 606203) PREDICTED: GRB2-associ ( 638) 921 113.0 3.9e-24
NP_001269212 (OMIM: 300482) GRB2-associated-bindin ( 548) 580 76.2 3.9e-13
XP_011529408 (OMIM: 300482) PREDICTED: GRB2-associ ( 572) 580 76.2 4e-13
NP_001075042 (OMIM: 300482) GRB2-associated-bindin ( 587) 580 76.2 4.1e-13
XP_011529407 (OMIM: 300482) PREDICTED: GRB2-associ ( 587) 580 76.2 4.1e-13
XP_005274705 (OMIM: 300482) PREDICTED: GRB2-associ ( 587) 580 76.2 4.1e-13
XP_006724867 (OMIM: 300482) PREDICTED: GRB2-associ ( 587) 580 76.2 4.1e-13
XP_016884765 (OMIM: 300482) PREDICTED: GRB2-associ ( 609) 580 76.2 4.3e-13
XP_011529405 (OMIM: 300482) PREDICTED: GRB2-associ ( 611) 580 76.2 4.3e-13
NP_542179 (OMIM: 300482) GRB2-associated-binding p ( 586) 576 75.8 5.6e-13
>>NP_997006 (OMIM: 604439) GRB2-associated-binding prote (724 aa)
initn: 4965 init1: 4965 opt: 4965 Z-score: 2906.8 bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4965; 100.0% identity (100.0% similar) in 724 aa overlap (1-724:1-724)
10 20 30 40 50 60
pF1KB5 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
670 680 690 700 710 720
pF1KB5 KSVK
::::
NP_997 KSVK
>>XP_016863457 (OMIM: 604439) PREDICTED: GRB2-associated (711 aa)
initn: 4800 init1: 4800 opt: 4804 Z-score: 2813.2 bits: 531.1 E(85289): 5.8e-150
Smith-Waterman score: 4804; 98.7% identity (99.2% similar) in 713 aa overlap (12-724:1-711)
10 20 30 40 50 60
pF1KB5 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
.:: :. :. ::::::::::::::::::::::::::::::::::::
XP_016 MRK--PHLYKKKKAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
10 20 30 40
70 80 90 100 110 120
pF1KB5 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB5 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB5 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB5 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB5 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB5 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB5 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB5 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH
470 480 490 500 510 520
550 560 570 580 590 600
pF1KB5 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
530 540 550 560 570 580
610 620 630 640 650 660
pF1KB5 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
590 600 610 620 630 640
670 680 690 700 710 720
pF1KB5 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
650 660 670 680 690 700
pF1KB5 KSVK
::::
XP_016 KSVK
710
>>XP_016863460 (OMIM: 604439) PREDICTED: GRB2-associated (621 aa)
initn: 4257 init1: 4257 opt: 4257 Z-score: 2495.8 bits: 472.2 E(85289): 2.8e-132
Smith-Waterman score: 4257; 100.0% identity (100.0% similar) in 621 aa overlap (104-724:1-621)
80 90 100 110 120 130
pF1KB5 FNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQ
::::::::::::::::::::::::::::::
XP_016 MNKWVRCICDICGFNPTEEDPVKPPGSSLQ
10 20 30
140 150 160 170 180 190
pF1KB5 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
40 50 60 70 80 90
200 210 220 230 240 250
pF1KB5 PEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSAS
100 110 120 130 140 150
260 270 280 290 300 310
pF1KB5 VDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTP
160 170 180 190 200 210
320 330 340 350 360 370
pF1KB5 GNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSY
220 230 240 250 260 270
380 390 400 410 420 430
pF1KB5 CIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVL
280 290 300 310 320 330
440 450 460 470 480 490
pF1KB5 TVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPA
340 350 360 370 380 390
500 510 520 530 540 550
pF1KB5 HMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDF
400 410 420 430 440 450
560 570 580 590 600 610
pF1KB5 ATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSH
460 470 480 490 500 510
620 630 640 650 660 670
pF1KB5 DSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQ
520 530 540 550 560 570
680 690 700 710 720
pF1KB5 KSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
580 590 600 610 620
>>NP_002030 (OMIM: 604439) GRB2-associated-binding prote (694 aa)
initn: 3667 init1: 3667 opt: 3711 Z-score: 2177.3 bits: 413.4 E(85289): 1.5e-114
Smith-Waterman score: 4696; 95.9% identity (95.9% similar) in 724 aa overlap (1-724:1-694)
10 20 30 40 50 60
pF1KB5 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH
::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRK------------
490 500 510 520
550 560 570 580 590 600
pF1KB5 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
::::::::::::::::::::::::::::::::::::::::::
NP_002 ------------------VKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
530 540 550 560 570
610 620 630 640 650 660
pF1KB5 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB5 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
640 650 660 670 680 690
pF1KB5 KSVK
::::
NP_002 KSVK
>>XP_016863458 (OMIM: 604439) PREDICTED: GRB2-associated (648 aa)
initn: 3596 init1: 3596 opt: 3631 Z-score: 2131.2 bits: 404.8 E(85289): 5.7e-112
Smith-Waterman score: 4187; 95.7% identity (95.8% similar) in 648 aa overlap (104-724:1-648)
80 90 100 110 120 130
pF1KB5 FNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQ
::::::::::::::::::::::::::::::
XP_016 MNKWVRCICDICGFNPTEEDPVKPPGSSLQ
10 20 30
140 150 160 170 180 190
pF1KB5 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
40 50 60 70 80 90
200 210 220
pF1KB5 PEPT---------------------------RTHADSAKSTSSETDCNDNVPSHKNPASS
:::: .::::::::::::::::::::::::::::
XP_016 PEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDCNDNVPSHKNPASS
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB5 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB5 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB5 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
280 290 300 310 320 330
410 420 430 440 450 460
pF1KB5 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
340 350 360 370 380 390
470 480 490 500 510 520
pF1KB5 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
400 410 420 430 440 450
530 540 550 560 570 580
pF1KB5 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
460 470 480 490 500 510
590 600 610 620 630 640
pF1KB5 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
520 530 540 550 560 570
650 660 670 680 690 700
pF1KB5 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
580 590 600 610 620 630
710 720
pF1KB5 WTDGRQSTESETPAKSVK
::::::::::::::::::
XP_016 WTDGRQSTESETPAKSVK
640
>>XP_006714230 (OMIM: 604439) PREDICTED: GRB2-associated (648 aa)
initn: 3596 init1: 3596 opt: 3631 Z-score: 2131.2 bits: 404.8 E(85289): 5.7e-112
Smith-Waterman score: 4187; 95.7% identity (95.8% similar) in 648 aa overlap (104-724:1-648)
80 90 100 110 120 130
pF1KB5 FNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQ
::::::::::::::::::::::::::::::
XP_006 MNKWVRCICDICGFNPTEEDPVKPPGSSLQ
10 20 30
140 150 160 170 180 190
pF1KB5 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
40 50 60 70 80 90
200 210 220
pF1KB5 PEPT---------------------------RTHADSAKSTSSETDCNDNVPSHKNPASS
:::: .::::::::::::::::::::::::::::
XP_006 PEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDCNDNVPSHKNPASS
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB5 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB5 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB5 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
280 290 300 310 320 330
410 420 430 440 450 460
pF1KB5 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
340 350 360 370 380 390
470 480 490 500 510 520
pF1KB5 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
400 410 420 430 440 450
530 540 550 560 570 580
pF1KB5 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
460 470 480 490 500 510
590 600 610 620 630 640
pF1KB5 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
520 530 540 550 560 570
650 660 670 680 690 700
pF1KB5 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
580 590 600 610 620 630
710 720
pF1KB5 WTDGRQSTESETPAKSVK
::::::::::::::::::
XP_006 WTDGRQSTESETPAKSVK
640
>>XP_016863459 (OMIM: 604439) PREDICTED: GRB2-associated (648 aa)
initn: 3596 init1: 3596 opt: 3631 Z-score: 2131.2 bits: 404.8 E(85289): 5.7e-112
Smith-Waterman score: 4187; 95.7% identity (95.8% similar) in 648 aa overlap (104-724:1-648)
80 90 100 110 120 130
pF1KB5 FNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQ
::::::::::::::::::::::::::::::
XP_016 MNKWVRCICDICGFNPTEEDPVKPPGSSLQ
10 20 30
140 150 160 170 180 190
pF1KB5 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
40 50 60 70 80 90
200 210 220
pF1KB5 PEPT---------------------------RTHADSAKSTSSETDCNDNVPSHKNPASS
:::: .::::::::::::::::::::::::::::
XP_016 PEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDCNDNVPSHKNPASS
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB5 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB5 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB5 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
280 290 300 310 320 330
410 420 430 440 450 460
pF1KB5 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
340 350 360 370 380 390
470 480 490 500 510 520
pF1KB5 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
400 410 420 430 440 450
530 540 550 560 570 580
pF1KB5 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
460 470 480 490 500 510
590 600 610 620 630 640
pF1KB5 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
520 530 540 550 560 570
650 660 670 680 690 700
pF1KB5 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
580 590 600 610 620 630
710 720
pF1KB5 WTDGRQSTESETPAKSVK
::::::::::::::::::
XP_016 WTDGRQSTESETPAKSVK
640
>>XP_006714231 (OMIM: 604439) PREDICTED: GRB2-associated (648 aa)
initn: 3596 init1: 3596 opt: 3631 Z-score: 2131.2 bits: 404.8 E(85289): 5.7e-112
Smith-Waterman score: 4187; 95.7% identity (95.8% similar) in 648 aa overlap (104-724:1-648)
80 90 100 110 120 130
pF1KB5 FNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQ
::::::::::::::::::::::::::::::
XP_006 MNKWVRCICDICGFNPTEEDPVKPPGSSLQ
10 20 30
140 150 160 170 180 190
pF1KB5 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
40 50 60 70 80 90
200 210 220
pF1KB5 PEPT---------------------------RTHADSAKSTSSETDCNDNVPSHKNPASS
:::: .::::::::::::::::::::::::::::
XP_006 PEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDCNDNVPSHKNPASS
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB5 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB5 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB5 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
280 290 300 310 320 330
410 420 430 440 450 460
pF1KB5 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
340 350 360 370 380 390
470 480 490 500 510 520
pF1KB5 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
400 410 420 430 440 450
530 540 550 560 570 580
pF1KB5 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
460 470 480 490 500 510
590 600 610 620 630 640
pF1KB5 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
520 530 540 550 560 570
650 660 670 680 690 700
pF1KB5 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
580 590 600 610 620 630
710 720
pF1KB5 WTDGRQSTESETPAKSVK
::::::::::::::::::
XP_006 WTDGRQSTESETPAKSVK
640
>>XP_016863456 (OMIM: 604439) PREDICTED: GRB2-associated (734 aa)
initn: 3596 init1: 3596 opt: 3631 Z-score: 2130.4 bits: 404.8 E(85289): 6.3e-112
Smith-Waterman score: 4723; 96.1% identity (96.3% similar) in 727 aa overlap (25-724:8-734)
10 20 30 40 50 60
pF1KB5 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
::::::::::::::::::::::::::::::::::::
XP_016 MLKADECAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
10 20 30 40
70 80 90 100 110 120
pF1KB5 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB5 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
110 120 130 140 150 160
190 200 210
pF1KB5 QDYLLLINCQSKKPEPT---------------------------RTHADSAKSTSSETDC
::::::::::::::::: .:::::::::::::::
XP_016 QDYLLLINCQSKKPEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDC
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB5 NDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKV
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB5 SPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB5 LDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDL
350 360 370 380 390 400
400 410 420 430 440 450
pF1KB5 NKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPN
410 420 430 440 450 460
460 470 480 490 500 510
pF1KB5 SPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVAD
470 480 490 500 510 520
520 530 540 550 560 570
pF1KB5 CEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWE
530 540 550 560 570 580
580 590 600 610 620 630
pF1KB5 ELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNL
590 600 610 620 630 640
640 650 660 670 680 690
pF1KB5 FGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVD
650 660 670 680 690 700
700 710 720
pF1KB5 QQKTLALKSTREAWTDGRQSTESETPAKSVK
:::::::::::::::::::::::::::::::
XP_016 QQKTLALKSTREAWTDGRQSTESETPAKSVK
710 720 730
>>XP_016863455 (OMIM: 604439) PREDICTED: GRB2-associated (738 aa)
initn: 3596 init1: 3596 opt: 3631 Z-score: 2130.4 bits: 404.8 E(85289): 6.4e-112
Smith-Waterman score: 4734; 95.0% identity (95.5% similar) in 740 aa overlap (12-724:1-738)
10 20 30 40 50 60
pF1KB5 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
.:: :. :. ::::::::::::::::::::::::::::::::::::
XP_016 MRK--PHLYKKKKAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
10 20 30 40
70 80 90 100 110 120
pF1KB5 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB5 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
110 120 130 140 150 160
190 200 210
pF1KB5 QDYLLLINCQSKKPEPT---------------------------RTHADSAKSTSSETDC
::::::::::::::::: .:::::::::::::::
XP_016 QDYLLLINCQSKKPEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDC
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB5 NDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKV
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB5 SPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB5 LDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDL
350 360 370 380 390 400
400 410 420 430 440 450
pF1KB5 NKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPN
410 420 430 440 450 460
460 470 480 490 500 510
pF1KB5 SPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVAD
470 480 490 500 510 520
520 530 540 550 560 570
pF1KB5 CEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWE
530 540 550 560 570 580
580 590 600 610 620 630
pF1KB5 ELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNL
590 600 610 620 630 640
640 650 660 670 680 690
pF1KB5 FGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVD
650 660 670 680 690 700
700 710 720
pF1KB5 QQKTLALKSTREAWTDGRQSTESETPAKSVK
:::::::::::::::::::::::::::::::
XP_016 QQKTLALKSTREAWTDGRQSTESETPAKSVK
710 720 730
724 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 16:11:38 2016 done: Sat Nov 5 16:11:40 2016
Total Scan time: 9.980 Total Display time: 0.170
Function used was FASTA [36.3.4 Apr, 2011]