Result of FASTA (omim) for
pFN21AB6684
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6684, 456 aa
1>>>pF1KB6684 456 - 456 aa - 456 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1200+/-0.000367; mu= 18.7031+/- 0.023
mean_var=69.4937+/-13.724, 0's: 0 Z-trim(114.0): 35 B-trim: 0 in 0/54
Lambda= 0.153851
statistics sampled from 23508 (23543) to 23508 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.276), width: 16
Scan time: 9.080
The best scores are: opt bits E(85289)
NP_056984 (OMIM: 607460) phospholipase A1 member A ( 456) 3095 696.2 4.6e-200
NP_001280154 (OMIM: 607460) phospholipase A1 membe ( 440) 2904 653.8 2.6e-187
NP_001193889 (OMIM: 607460) phospholipase A1 membe ( 440) 2070 468.7 1.4e-131
XP_016862061 (OMIM: 607460) PREDICTED: phospholipa ( 283) 1934 438.4 1.2e-122
NP_001193890 (OMIM: 607460) phospholipase A1 membe ( 283) 1934 438.4 1.2e-122
NP_640341 (OMIM: 604379,607365) lipase member H pr ( 451) 891 207.0 8.5e-53
NP_001289930 (OMIM: 145750,609252) lipase member I ( 375) 878 204.1 5.4e-52
NP_945347 (OMIM: 145750,609252) lipase member I is ( 481) 867 201.7 3.6e-51
XP_006724028 (OMIM: 145750,609252) PREDICTED: lipa ( 404) 861 200.3 7.8e-51
NP_001289927 (OMIM: 145750,609252) lipase member I ( 460) 861 200.4 8.7e-51
XP_011510833 (OMIM: 604379,607365) PREDICTED: lipa ( 408) 857 199.4 1.5e-50
XP_011510832 (OMIM: 604379,607365) PREDICTED: lipa ( 408) 857 199.4 1.5e-50
NP_001289929 (OMIM: 145750,609252) lipase member I ( 454) 832 193.9 7.5e-49
XP_006713592 (OMIM: 604379,607365) PREDICTED: lipa ( 421) 537 128.4 3.6e-29
NP_001289928 (OMIM: 145750,609252) lipase member I ( 430) 507 121.8 3.7e-27
NP_006024 (OMIM: 603684) endothelial lipase isofor ( 500) 506 121.6 4.9e-27
NP_005387 (OMIM: 604423) pancreatic lipase-related ( 470) 501 120.5 1e-26
XP_005258447 (OMIM: 603684) PREDICTED: endothelial ( 536) 486 117.2 1.1e-25
NP_000927 (OMIM: 246600,614338) pancreatic triacyl ( 465) 467 112.9 1.9e-24
XP_011524569 (OMIM: 603684) PREDICTED: endothelial ( 420) 446 108.2 4.3e-23
NP_006220 (OMIM: 604422) inactive pancreatic lipas ( 467) 420 102.5 2.6e-21
XP_011538170 (OMIM: 604422) PREDICTED: inactive pa ( 467) 420 102.5 2.6e-21
NP_001290064 (OMIM: 604422) inactive pancreatic li ( 467) 420 102.5 2.6e-21
NP_000228 (OMIM: 144250,238600,609708) lipoprotein ( 475) 414 101.2 6.6e-21
XP_016871828 (OMIM: 604423) PREDICTED: pancreatic ( 249) 400 97.8 3.4e-20
NP_000227 (OMIM: 125853,151670,612797,614025) hepa ( 499) 386 95.0 5.1e-19
XP_005254429 (OMIM: 125853,151670,612797,614025) P ( 499) 386 95.0 5.1e-19
XP_016861341 (OMIM: 604379,607365) PREDICTED: lipa ( 417) 385 94.7 5.1e-19
XP_016877665 (OMIM: 125853,151670,612797,614025) P ( 398) 383 94.2 6.7e-19
XP_005254431 (OMIM: 125853,151670,612797,614025) P ( 511) 383 94.3 8.2e-19
XP_006720565 (OMIM: 125853,151670,612797,614025) P ( 452) 381 93.8 1e-18
XP_016881584 (OMIM: 603684) PREDICTED: endothelial ( 303) 303 76.4 1.2e-13
NP_001294935 (OMIM: 603684) endothelial lipase iso ( 426) 267 68.5 4e-11
XP_011538171 (OMIM: 604422) PREDICTED: inactive pa ( 318) 259 66.6 1.1e-10
XP_011524567 (OMIM: 603684) PREDICTED: endothelial ( 462) 247 64.1 9.2e-10
>>NP_056984 (OMIM: 607460) phospholipase A1 member A iso (456 aa)
initn: 3095 init1: 3095 opt: 3095 Z-score: 3712.7 bits: 696.2 E(85289): 4.6e-200
Smith-Waterman score: 3095; 100.0% identity (100.0% similar) in 456 aa overlap (1-456:1-456)
10 20 30 40 50 60
pF1KB6 MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 PSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 WIYGSTGVYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 WIYGSTGVYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 GQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 DQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 LLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 FLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFC
370 380 390 400 410 420
430 440 450
pF1KB6 TALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
::::::::::::::::::::::::::::::::::::
NP_056 TALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
430 440 450
>>NP_001280154 (OMIM: 607460) phospholipase A1 member A (440 aa)
initn: 2904 init1: 2904 opt: 2904 Z-score: 3483.8 bits: 653.8 E(85289): 2.6e-187
Smith-Waterman score: 2904; 100.0% identity (100.0% similar) in 432 aa overlap (25-456:9-440)
10 20 30 40 50 60
pF1KB6 MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSN
::::::::::::::::::::::::::::::::::::
NP_001 MHKSSSIWGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSN
10 20 30 40
70 80 90 100 110 120
pF1KB6 PSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVD
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB6 WIYGSTGVYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WIYGSTGVYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFG
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB6 GQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQ
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB6 DQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPF
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB6 LLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVT
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB6 FLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFC
350 360 370 380 390 400
430 440 450
pF1KB6 TALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
::::::::::::::::::::::::::::::::::::
NP_001 TALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
410 420 430 440
>>NP_001193889 (OMIM: 607460) phospholipase A1 member A (440 aa)
initn: 2070 init1: 2070 opt: 2070 Z-score: 2483.3 bits: 468.7 E(85289): 1.4e-131
Smith-Waterman score: 2965; 96.5% identity (96.5% similar) in 456 aa overlap (1-456:1-440)
10 20 30 40 50 60
pF1KB6 MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 PSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 WIYGSTGVYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFG
:::::::::::::::: ::::::::::::::::::::::::::::
NP_001 WIYGSTGVYFSAVKNV----------------LGVSESSIHIIGVSLGAHVGGMVGQLFG
130 140 150 160
190 200 210 220 230 240
pF1KB6 GQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQ
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB6 DQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPF
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB6 LLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVT
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB6 FLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFC
350 360 370 380 390 400
430 440 450
pF1KB6 TALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
::::::::::::::::::::::::::::::::::::
NP_001 TALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
410 420 430 440
>>XP_016862061 (OMIM: 607460) PREDICTED: phospholipase A (283 aa)
initn: 1934 init1: 1934 opt: 1934 Z-score: 2322.9 bits: 438.4 E(85289): 1.2e-122
Smith-Waterman score: 1934; 100.0% identity (100.0% similar) in 283 aa overlap (174-456:1-283)
150 160 170 180 190 200
pF1KB6 SLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRASVEE
::::::::::::::::::::::::::::::
XP_016 MVGQLFGGQLGQITGLDPAGPEYTRASVEE
10 20 30
210 220 230 240 250 260
pF1KB6 RLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRA
40 50 60 70 80 90
270 280 290 300 310 320
pF1KB6 VHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKE
100 110 120 130 140 150
330 340 350 360 370 380
pF1KB6 VKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKG
160 170 180 190 200 210
390 400 410 420 430 440
pF1KB6 IIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQA
220 230 240 250 260 270
450
pF1KB6 SVTVSCDLKIACV
:::::::::::::
XP_016 SVTVSCDLKIACV
280
>>NP_001193890 (OMIM: 607460) phospholipase A1 member A (283 aa)
initn: 1934 init1: 1934 opt: 1934 Z-score: 2322.9 bits: 438.4 E(85289): 1.2e-122
Smith-Waterman score: 1934; 100.0% identity (100.0% similar) in 283 aa overlap (174-456:1-283)
150 160 170 180 190 200
pF1KB6 SLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRASVEE
::::::::::::::::::::::::::::::
NP_001 MVGQLFGGQLGQITGLDPAGPEYTRASVEE
10 20 30
210 220 230 240 250 260
pF1KB6 RLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRA
40 50 60 70 80 90
270 280 290 300 310 320
pF1KB6 VHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKE
100 110 120 130 140 150
330 340 350 360 370 380
pF1KB6 VKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKG
160 170 180 190 200 210
390 400 410 420 430 440
pF1KB6 IIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQA
220 230 240 250 260 270
450
pF1KB6 SVTVSCDLKIACV
:::::::::::::
NP_001 SVTVSCDLKIACV
280
>>NP_640341 (OMIM: 604379,607365) lipase member H precur (451 aa)
initn: 751 init1: 622 opt: 891 Z-score: 1068.9 bits: 207.0 E(85289): 8.5e-53
Smith-Waterman score: 891; 35.4% identity (69.1% similar) in 404 aa overlap (23-416:14-411)
10 20 30 40 50
pF1KB6 MPPGPWESCFWVGGLILWLSVGSSGDAPPT-PQPKCADFQSANLFEGTDLKVQFLLFVPS
: .:: : :. .:.:: . :: :.:...:.. .
NP_640 MLRFYLFISLLCLSRSDAEETCPSFTRLSFHSAVV--GTGLNVRLMLYTRK
10 20 30 40
60 70 80 90 100 110
pF1KB6 NPSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAV
: .:.: .. :: . : .:.: : .:.:::: :. : :.: ... :: . . ::..:
NP_640 NLTCAQTIN-SSAFGN--LNVTKKTTFIVHGFRPTGSPPVWMDDLVKGLLSVEDMNVVVV
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 DWIYGSTG-VYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQL
:: :.: .: : ... :... .. :....:. :.: ..:..::::::::..:.::..
NP_640 DWNRGATTLIYTHASSKTRKVAMVLKEFIDQMLAEGASLDDIYMIGVSLGAHISGFVGEM
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB6 FGGQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNG
. : ::.::::::::: .. ..::: .:: ::..::.::: :: . :.:..:.. ::
NP_640 YDGWLGRITGLDPAGPLFNGKPHQDRLDPSDAQFVDVIHSDTDALGYKEPLGNIDFYPNG
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB6 GQDQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFN
: :::::: . .:..:. :::.:.:.::.:.:..:: . :.:: ::. . :.:..: .
NP_640 GLDQPGCPKTILGGFQYFKCDHQRSVYLYLSSLRESCTITAYPCDSYQDYRNGKCVSCGT
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB6 PFLLSCPRIGLVE---QGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHL--KELRNK
::: .: . .. . : .:... :. .:.::.: .:.. :..:
NP_640 SQKESCPLLGYYADNWKDHLRGKD-PPMTKAFFDTAEESPFCMYHYFVDIITWNKNVRRG
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB6 DTNIEVTFLSSNITSSSKITIPKQ-QRYGK-GIIAHATPQC-QINQVKFKFQSSNRVWKK
: .:.. ..: : :. : :.: . ...:. . . .. ... :.... . .
NP_640 DITIKLRDKAGNTTESKINHEPTTFQKYHQVSLLARFNQDLDKVAAISLMFSTGSLIGPR
350 360 370 380 390 400
420 430 440 450
pF1KB6 DRTTIIGKFCTALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
. :.
NP_640 YKLRILRMKLRSLAHPERPQLCRYDLVLMENVETVFQPILCPELQL
410 420 430 440 450
>>NP_001289930 (OMIM: 145750,609252) lipase member I iso (375 aa)
initn: 817 init1: 652 opt: 878 Z-score: 1054.4 bits: 204.1 E(85289): 5.4e-52
Smith-Waterman score: 878; 42.3% identity (73.9% similar) in 307 aa overlap (53-351:45-350)
30 40 50 60 70 80
pF1KB6 SSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSNPSCGQ-LVEGSSDLQNSGFNAT
..... .: .:.. : : ...: : .::.
NP_001 SDNKRPCLEFSQLSVKDSFRDLFIPRIETILMMYTRNNLNCAEPLFEQNNSL-NVNFNTQ
20 30 40 50 60 70
90 100 110 120 130 140
pF1KB6 LGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVDWIYGSTG-VYFSAVKNVIKLS
: .:::.: .:. : :...:.: :: . :::.::: :.: .: ::::. :..
NP_001 KKTVWLIHGYRPVGSIPLWLQNFVRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVA
80 90 100 110 120 130
150 160 170 180 190 200
pF1KB6 LEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRAS
. .:. ...:: :.: ...:.::::::::..:.::..: ::::.:::::::::...:
NP_001 VSLSVHIKNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKP
140 150 160 170 180 190
210 220 230 240 250 260
pF1KB6 VEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDH
::: :: ::..::.:...:::. :.::.:.. :::. ::::: ...: ... :.:
NP_001 PYSRLDYTDAKFVDVIHSDSNGLGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNH
200 210 220 230 240 250
270 280 290 300 310
pF1KB6 MRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQ--GGV---
.:::::....::..: ...::: ::: . .. :.:: ::::.: . ::
NP_001 QRAVHLFMASLETNCNFISFPCRSYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKE
260 270 280 290 300 310
320 330 340 350 360 370
pF1KB6 KIEPLPKEVKVYLLTTSSAPYCMHH-SLVEFHLKELRNKDTNIEVTFLSSNITSSSKITI
..: : .. :.: :... :.: :: . . ..:: :
NP_001 RMEGRPLRTTVFLDTSGTYPFCNHHFAGIILYLKTERKCFLIQTHVHQRTHKMPSSIKCT
320 330 340 350 360 370
380 390 400 410 420 430
pF1KB6 PKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVC
NP_001 CL
>>NP_945347 (OMIM: 145750,609252) lipase member I isofor (481 aa)
initn: 817 init1: 652 opt: 867 Z-score: 1039.7 bits: 201.7 E(85289): 3.6e-51
Smith-Waterman score: 867; 39.6% identity (70.7% similar) in 338 aa overlap (16-340:26-359)
10 20 30 40
pF1KB6 MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEG-TDL
.::: : . : : .:.. .. .. ::
NP_945 MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVCLRSDNKRP---CLEFSQLSVKDSFRDL
10 20 30 40 50
50 60 70 80 90 100
pF1KB6 KVQ-----FLLFVPSNPSCGQ-LVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDT
. ..... .: .:.. : : ...: : .::. : .:::.: .:. : :...
NP_945 FIPRIETILMMYTRNNLNCAEPLFEQNNSL-NVNFNTQKKTVWLIHGYRPVGSIPLWLQN
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 FIRTLLRATNANVIAVDWIYGSTG-VYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHI
:.: :: . :::.::: :.: .: ::::. :... .:. ...:: :.: ...:.
NP_945 FVRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHF
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB6 IGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDN
::::::::..:.::..: ::::.:::::::::...: ::: :: ::..::.:...
NP_945 IGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNG
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB6 LGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPC
:::. :.::.:.. :::. ::::: ...: ... :.:.:::::....::..: ...:::
NP_945 LGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPC
240 250 260 270 280 290
290 300 310 320 330
pF1KB6 ASYKAFLAGRCLDCFNPFLLSCPRIGLVEQ--GGV---KIEPLPKEVKVYLLTTSSAPYC
::: . .. :.:: ::::.: . :: ..: : .. :.: :... :.:
NP_945 RSYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFC
300 310 320 330 340 350
340 350 360 370 380 390
pF1KB6 MHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQV
..
NP_945 TYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFV
360 370 380 390 400 410
>>XP_006724028 (OMIM: 145750,609252) PREDICTED: lipase m (404 aa)
initn: 817 init1: 652 opt: 861 Z-score: 1033.6 bits: 200.3 E(85289): 7.8e-51
Smith-Waterman score: 861; 42.4% identity (74.6% similar) in 295 aa overlap (53-340:74-367)
30 40 50 60 70 80
pF1KB6 SSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSNPSCGQ-LVEGSSDLQNSGFNAT
..... .: .:.. : : ...: : .::.
XP_006 SDNKRPCLEFSQLSVKDSFRDLFIPRIETILMMYTRNNLNCAEPLFEQNNSL-NVNFNTQ
50 60 70 80 90 100
90 100 110 120 130 140
pF1KB6 LGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVDWIYGSTG-VYFSAVKNVIKLS
: .:::.: .:. : :...:.: :: . :::.::: :.: .: ::::. :..
XP_006 KKTVWLIHGYRPVGSIPLWLQNFVRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVA
110 120 130 140 150 160
150 160 170 180 190 200
pF1KB6 LEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRAS
. .:. ...:: :.: ...:.::::::::..:.::..: ::::.:::::::::...:
XP_006 VSLSVHIKNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKP
170 180 190 200 210 220
210 220 230 240 250 260
pF1KB6 VEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDH
::: :: ::..::.:...:::. :.::.:.. :::. ::::: ...: ... :.:
XP_006 PYSRLDYTDAKFVDVIHSDSNGLGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNH
230 240 250 260 270 280
270 280 290 300 310
pF1KB6 MRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQ--GGV---
.:::::....::..: ...::: ::: . .. :.:: ::::.: . ::
XP_006 QRAVHLFMASLETNCNFISFPCRSYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKE
290 300 310 320 330 340
320 330 340 350 360 370
pF1KB6 KIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIP
..: : .. :.: :... :.: ..
XP_006 RMEGRPLRTTVFLDTSGTYPFCTYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYE
350 360 370 380 390 400
>>NP_001289927 (OMIM: 145750,609252) lipase member I iso (460 aa)
initn: 817 init1: 652 opt: 861 Z-score: 1032.8 bits: 200.4 E(85289): 8.7e-51
Smith-Waterman score: 861; 42.4% identity (74.6% similar) in 295 aa overlap (53-340:45-338)
30 40 50 60 70 80
pF1KB6 SSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSNPSCGQ-LVEGSSDLQNSGFNAT
..... .: .:.. : : ...: : .::.
NP_001 SDNKRPCLEFSQLSVKDSFRDLFIPRIETILMMYTRNNLNCAEPLFEQNNSL-NVNFNTQ
20 30 40 50 60 70
90 100 110 120 130 140
pF1KB6 LGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVDWIYGSTG-VYFSAVKNVIKLS
: .:::.: .:. : :...:.: :: . :::.::: :.: .: ::::. :..
NP_001 KKTVWLIHGYRPVGSIPLWLQNFVRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVA
80 90 100 110 120 130
150 160 170 180 190 200
pF1KB6 LEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRAS
. .:. ...:: :.: ...:.::::::::..:.::..: ::::.:::::::::...:
NP_001 VSLSVHIKNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKP
140 150 160 170 180 190
210 220 230 240 250 260
pF1KB6 VEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDH
::: :: ::..::.:...:::. :.::.:.. :::. ::::: ...: ... :.:
NP_001 PYSRLDYTDAKFVDVIHSDSNGLGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNH
200 210 220 230 240 250
270 280 290 300 310
pF1KB6 MRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQ--GGV---
.:::::....::..: ...::: ::: . .. :.:: ::::.: . ::
NP_001 QRAVHLFMASLETNCNFISFPCRSYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKE
260 270 280 290 300 310
320 330 340 350 360 370
pF1KB6 KIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIP
..: : .. :.: :... :.: ..
NP_001 RMEGRPLRTTVFLDTSGTYPFCTYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYE
320 330 340 350 360 370
456 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:45:55 2016 done: Sat Nov 5 11:45:56 2016
Total Scan time: 9.080 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]