Result of FASTA (omim) for
pFN21AB6672
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6672, 454 aa
1>>>pF1KB6672 454 - 454 aa - 454 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6855+/-0.000358; mu= 16.4259+/- 0.022
mean_var=81.4733+/-15.831, 0's: 0 Z-trim(114.7): 77 B-trim: 421 in 1/51
Lambda= 0.142091
statistics sampled from 24556 (24637) to 24556 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.289), width: 16
Scan time: 8.240
The best scores are: opt bits E(85289)
NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 3080 641.2 1.7e-183
NP_001316683 (OMIM: 112265) bone morphogenetic pro ( 417) 2466 515.3 1.2e-145
XP_011513119 (OMIM: 112265) PREDICTED: bone morpho ( 357) 2275 476.1 6.7e-134
NP_001316685 (OMIM: 112265) bone morphogenetic pro ( 348) 2273 475.7 8.8e-134
NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 1643 346.6 9e-95
NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 1632 344.3 3.7e-94
XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 1562 329.8 4.9e-90
NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 1218 259.4 1.2e-68
XP_011540324 (OMIM: 602284) PREDICTED: bone morpho ( 357) 940 202.4 1.6e-51
XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427) 645 142.0 3e-33
XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 534 119.3 2.4e-26
NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 534 119.3 2.4e-26
NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 534 119.3 2.4e-26
XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 502 112.6 1.7e-24
XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 502 112.6 1.7e-24
XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 502 112.7 1.9e-24
NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 502 112.7 1.9e-24
NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 502 112.7 1.9e-24
XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 502 112.7 1.9e-24
XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 488 109.6 9.2e-24
NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 488 109.8 1.4e-23
XP_016857645 (OMIM: 602284) PREDICTED: bone morpho ( 236) 474 106.8 6.6e-23
XP_011540327 (OMIM: 602284) PREDICTED: bone morpho ( 230) 466 105.1 2e-22
XP_005271206 (OMIM: 602284) PREDICTED: bone morpho ( 231) 466 105.1 2e-22
NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 452 102.4 2.5e-21
NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 449 101.8 3.9e-21
NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 421 96.0 1.8e-19
NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 404 92.6 2.4e-18
NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 398 91.4 5.3e-18
NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 396 90.9 6.2e-18
NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 383 88.3 4.4e-17
NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 371 85.8 2.3e-16
XP_016857644 (OMIM: 602284) PREDICTED: bone morpho ( 382) 367 85.0 3.9e-16
NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 368 85.2 4.1e-16
NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 343 79.9 7.4e-15
NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 343 80.0 1.1e-14
NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 344 80.3 1.1e-14
XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 344 80.3 1.1e-14
XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 344 80.3 1.2e-14
XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 344 80.3 1.4e-14
NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 298 70.8 7.5e-12
XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276) 290 69.1 1.7e-11
XP_005272014 (OMIM: 601918) PREDICTED: growth/diff ( 366) 290 69.2 2.1e-11
NP_001275754 (OMIM: 601918) growth/differentiation ( 366) 290 69.2 2.1e-11
XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366) 290 69.2 2.1e-11
XP_011541612 (OMIM: 601918) PREDICTED: growth/diff ( 366) 290 69.2 2.1e-11
NP_001275757 (OMIM: 601918) growth/differentiation ( 366) 290 69.2 2.1e-11
NP_001275755 (OMIM: 601918) growth/differentiation ( 366) 290 69.2 2.1e-11
NP_001275756 (OMIM: 601918) growth/differentiation ( 366) 290 69.2 2.1e-11
NP_001275753 (OMIM: 601918) growth/differentiation ( 366) 290 69.2 2.1e-11
>>NP_066551 (OMIM: 112265) bone morphogenetic protein 5 (454 aa)
initn: 3080 init1: 3080 opt: 3080 Z-score: 3415.2 bits: 641.2 E(85289): 1.7e-183
Smith-Waterman score: 3080; 100.0% identity (100.0% similar) in 454 aa overlap (1-454:1-454)
10 20 30 40 50 60
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA
370 380 390 400 410 420
430 440 450
pF1KB6 PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
::::::::::::::::::::::::::::::::::
NP_066 PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
430 440 450
>>NP_001316683 (OMIM: 112265) bone morphogenetic protein (417 aa)
initn: 2799 init1: 2459 opt: 2466 Z-score: 2735.5 bits: 515.3 E(85289): 1.2e-145
Smith-Waterman score: 2729; 91.9% identity (91.9% similar) in 454 aa overlap (1-454:1-417)
10 20 30 40 50 60
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA
:::::::: :::::::::::::::
NP_001 SFRDLGWQ-------------------------------------VHLMFPDHVPKPCCA
370 380
430 440 450
pF1KB6 PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
::::::::::::::::::::::::::::::::::
NP_001 PTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
390 400 410
>>XP_011513119 (OMIM: 112265) PREDICTED: bone morphogene (357 aa)
initn: 2304 init1: 2275 opt: 2275 Z-score: 2524.9 bits: 476.1 E(85289): 6.7e-134
Smith-Waterman score: 2275; 99.7% identity (100.0% similar) in 343 aa overlap (1-343:1-343)
10 20 30 40 50 60
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
::::::::::::::::::::::::::::::::::::::::::.
XP_011 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGETLHKTTRWNSLDFS
310 320 330 340 350
370 380 390 400 410 420
pF1KB6 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA
>>NP_001316685 (OMIM: 112265) bone morphogenetic protein (348 aa)
initn: 2273 init1: 2273 opt: 2273 Z-score: 2522.8 bits: 475.7 E(85289): 8.8e-134
Smith-Waterman score: 2273; 100.0% identity (100.0% similar) in 342 aa overlap (1-342:1-342)
10 20 30 40 50 60
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYV
::::::::::::::::::::::::::::::::::::::::::
NP_001 MVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGGSSDVS
310 320 330 340
370 380 390 400 410 420
pF1KB6 SFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCA
>>NP_001709 (OMIM: 112266) bone morphogenetic protein 6 (513 aa)
initn: 1074 init1: 810 opt: 1643 Z-score: 1822.4 bits: 346.6 E(85289): 9e-95
Smith-Waterman score: 1742; 59.3% identity (79.6% similar) in 450 aa overlap (36-454:64-513)
10 20 30 40 50 60
pF1KB6 FLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRP
:.:.::::...:.::.:.::::.:::::::
NP_001 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP
40 50 60 70 80 90
70 80 90
pF1KB6 RPFS---------------------------PGKQASSAPLFMLDLYNAMTNEENPE-ES
::. : . .::::::::::::.. ... . :
NP_001 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAPLFMLDLYNALSADNDEDGAS
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB6 EYSVRASLAEET-RGARKGYPASPNGYP-RRIQLSRTTPLTTQSPPLASLHDTNFLNDAD
: . : .:. .... : ..: : .: . . ::.: .:. ::::::
NP_001 EGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDAD
160 170 180 190 200 210
160 170 180 190 200 210
pF1KB6 MVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIK
:::::::::: ::.:: ..::.:::.:.:.:::.::.::::::::::: . :.:.:.
NP_001 MVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFL
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB6 ISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAET
:::::...:. .::.:::::::: . : . ::: ::::.::: ::..::.:.:::: . :
NP_001 ISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVT
280 290 300 310 320 330
280 290 300 310 320 330
pF1KB6 GDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAAN-KRKNQNRNKSSSHQD
:: .. ..::::::.:: .::::::::::.::: .:..:.:. .:..:.::.:.. ::
NP_001 RDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQD
340 350 360 370 380 390
340 350 360 370 380 390
pF1KB6 SSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHM
.:.::..:::.:: : ::.::::::::.:::::::::::.:::: ::::::::::::::
NP_001 VARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHM
400 410 420 430 440 450
400 410 420 430 440 450
pF1KB6 NATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
::::::::::::::: :..:::::::::::::::::::::.::::::::::::::.::::
NP_001 NATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
460 470 480 490 500 510
>>NP_001710 (OMIM: 112267) bone morphogenetic protein 7 (431 aa)
initn: 1098 init1: 874 opt: 1632 Z-score: 1811.3 bits: 344.3 E(85289): 3.7e-94
Smith-Waterman score: 1898; 64.7% identity (84.2% similar) in 442 aa overlap (15-454:17-431)
10 20 30 40 50
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLG-DNHVHSSFIYRRLRNHERREIQREILS
::. :. : . .. ::.::::::.::::..::::.::::::
NP_001 MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 ILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYP
:::::::::: ::. .:::.:::::::::. ::. :. :
NP_001 ILGLPHRPRPHLQGKH-NSAPMFMLDLYNAMAVEEG-----------------GGPGGQG
70 80 90 100
120 130 140 150 160 170
pF1KB6 ASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHY
: :: . .: ::.::::::.:..::.:::::::::::::.::.: : : :.
NP_001 FS---YPYKAVFS------TQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHH
110 120 130 140 150
180 190 200 210 220 230
pF1KB6 KEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDT
.::::::..::.:::::::::::::: .::.:::..::.::...:. .:..::::::.
NP_001 REFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDS
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB6 RKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSK
: : . ::::::::.::::::.::..:::::: .:: ::.::: : :::.::.:::.:
NP_001 RTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNK
220 230 240 250 260 270
300 310 320 330 340 350
pF1KB6 QPFMVAFFKASEVLLRSVRAA-NKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKH
::::::::::.:: .::.:.. .:...:::.:. ..:.. ::..:.. ..:.:.::::::
NP_001 QPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKH
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB6 ELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPK
:::::::::::::::::::::::.::.:::.::::..::::::::::::::.. :. :::
NP_001 ELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPK
340 350 360 370 380 390
420 430 440 450
pF1KB6 PCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
::::::.::::::::::::::::::::::::::.::::
NP_001 PCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH
400 410 420 430
>>XP_016866687 (OMIM: 112265) PREDICTED: bone morphogene (239 aa)
initn: 1562 init1: 1562 opt: 1562 Z-score: 1737.5 bits: 329.8 E(85289): 4.9e-90
Smith-Waterman score: 1562; 99.6% identity (99.6% similar) in 229 aa overlap (226-454:11-239)
200 210 220 230 240 250
pF1KB6 AEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVT
: ::::::::::::::::::::::::::::
XP_016 MEAERAQVLPTVRDADLFLLDTRKAQALDVGWLVFDITVT
10 20 30 40
260 270 280 290 300 310
pF1KB6 SNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSV
50 60 70 80 90 100
320 330 340 350 360 370
pF1KB6 RAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPE
110 120 130 140 150 160
380 390 400 410 420 430
pF1KB6 GYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDS
170 180 190 200 210 220
440 450
pF1KB6 SNVILKKYRNMVVRSCGCH
:::::::::::::::::::
XP_016 SNVILKKYRNMVVRSCGCH
230
>>NP_001711 (OMIM: 602284) bone morphogenetic protein 8B (402 aa)
initn: 895 init1: 765 opt: 1218 Z-score: 1353.1 bits: 259.4 E(85289): 1.2e-68
Smith-Waterman score: 1342; 47.5% identity (72.3% similar) in 455 aa overlap (8-454:1-402)
10 20 30 40 50
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDN----HVHSSFIYRRLRNHERREIQREIL
. .. : :: :.: : .:: . . . ::: .:::..:::::
NP_001 MTALPGPLW----LLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREIL
10 20 30 40
60 70 80 90 100 110
pF1KB6 SILGLPHRPRPFSP---GKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGAR
..:::: :::: .: .. .::::::::::.::..... .
NP_001 AVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDED------------------
50 60 70 80 90
120 130 140 150 160 170
pF1KB6 KGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQ
: :: :: :. ::.::::::.::::. ..::
NP_001 -GAPAE-----RR------------------------LGRADLVMSFVNMVERDRALGHQ
100 110 120
180 190 200 210 220 230
pF1KB6 RRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLF
. :.::::::::::: ::::::::::::: : . . :.:...:..:...: .::..:::
NP_001 EPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL-NRTLHVSMFQVVQEQSNRESDLF
130 140 150 160 170 180
240 250 260 270 280 290
pF1KB6 LLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQG
.:: . .: : ::::.:.:..:. :... ...:::.: .:: ::.:.. :::.:...
NP_001 FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA
190 200 210 220 230 240
300 310 320 330 340 350
pF1KB6 PQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSV-GDYNTSEQKQA
:.:.:::.:.::.:: .:. ::. . .. .::. ...:. .. : . :. .:.
NP_001 PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB6 CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPD
:..:::::::.:::: ::.:::.::.:.::.:::::::.. ::::::::.:.:::::.::
NP_001 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD
310 320 330 340 350 360
420 430 440 450
pF1KB6 HVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
::: :::::::.: ::::.:.:.::::.:.:::::..::::
NP_001 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
370 380 390 400
>>XP_011540324 (OMIM: 602284) PREDICTED: bone morphogene (357 aa)
initn: 904 init1: 484 opt: 940 Z-score: 1045.9 bits: 202.4 E(85289): 1.6e-51
Smith-Waterman score: 1064; 44.1% identity (69.7% similar) in 406 aa overlap (8-405:1-353)
10 20 30 40 50
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDN----HVHSSFIYRRLRNHERREIQREIL
. .. : :: :.: : .:: . . . ::: .:::..:::::
XP_011 MTALPGPLW----LLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREIL
10 20 30 40
60 70 80 90 100 110
pF1KB6 SILGLPHRPRPFSP---GKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGAR
..:::: :::: .: .. .::::::::::.::..... .
XP_011 AVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDED------------------
50 60 70 80 90
120 130 140 150 160 170
pF1KB6 KGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQ
: :: :: :. ::.::::::.::::. ..::
XP_011 -GAPAE-----RR------------------------LGRADLVMSFVNMVERDRALGHQ
100 110 120
180 190 200 210 220 230
pF1KB6 RRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLF
. :.::::::::::: ::::::::::::: : . . :.:...:..:...: .::..:::
XP_011 EPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL-NRTLHVSMFQVVQEQSNRESDLF
130 140 150 160 170 180
240 250 260 270 280 290
pF1KB6 LLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQG
.:: . .: : ::::.:.:..:. :... ...:::.: .:: ::.:.. :::.:...
XP_011 FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA
190 200 210 220 230 240
300 310 320 330 340 350
pF1KB6 PQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSV-GDYNTSEQKQA
:.:.:::.:.::.:: .:. ::. . .. .::. ...:. .. : . :. .:.
XP_011 PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB6 CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPD
:..:::::::.:::: ::.:::.::.:.::.:::::::.. ::::::::.:.:
XP_011 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLEVQR
310 320 330 340 350
420 430 440 450
pF1KB6 HVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
>>XP_011540326 (OMIM: 602284) PREDICTED: bone morphogene (427 aa)
initn: 1213 init1: 617 opt: 645 Z-score: 717.9 bits: 142.0 E(85289): 3e-33
Smith-Waterman score: 1186; 43.5% identity (67.5% similar) in 480 aa overlap (8-454:1-427)
10 20 30 40 50
pF1KB6 MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDN----HVHSSFIYRRLRNHERREIQREIL
. .. : :: :.: : .:: . . . ::: .:::..:::::
XP_011 MTALPGPLW----LLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREIL
10 20 30 40
60 70 80 90 100 110
pF1KB6 SILGLPHRPRPFSP---GKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGAR
..:::: :::: .: .. .::::::::::.::..... .
XP_011 AVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDED------------------
50 60 70 80 90
120 130 140 150 160 170
pF1KB6 KGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQ
: :: :: :. ::.::::::.::::. ..::
XP_011 -GAPAE-----RR------------------------LGRADLVMSFVNMVERDRALGHQ
100 110 120
180 190 200 210 220 230
pF1KB6 RRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLF
. :.::::::::::: ::::::::::::: : . . :.:...:..:...: .::..:::
XP_011 EPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLL-NRTLHVSMFQVVQEQSNRESDLF
130 140 150 160 170 180
240 250 260 270 280
pF1KB6 LLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSIN----VKSAGL-
.:: . .: : ::::.:.:..:. :... ...:::.: .:: ::.. . .:.. :
XP_011 FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGETWTGWGWTKDSRLQ
190 200 210 220 230 240
290 300 310 320
pF1KB6 -----VGRQ---------GPQ---SKQPFMVAF---FKASEVLLRSVRAANKRKNQNRNK
..: :: ...:.. . :: .:. ::. . .. .:
XP_011 MWKLRLSRTPWVLSLHAPGPAQAPAERPLLCLLQGHCPASPSPIRTPRAVRPLRRRQPKK
250 260 270 280 290 300
330 340 350 360 370 380
pF1KB6 SSSHQDSSRMSSV-GDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECS
:. ...:. .. : . :. .:.:..:::::::.:::: ::.:::.::.:.::.::::
XP_011 SNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECS
310 320 330 340 350 360
390 400 410 420 430 440
pF1KB6 FPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMV
:::.. ::::::::.:.:::::.:: ::: :::::::.: ::::.:.:.::::.:.::::
XP_011 FPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMV
370 380 390 400 410 420
450
pF1KB6 VRSCGCH
:..::::
XP_011 VKACGCH
454 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:20:17 2016 done: Sat Nov 5 11:20:18 2016
Total Scan time: 8.240 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]