Result of FASTA (omim) for
pFN21AB6618
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6618, 433 aa
1>>>pF1KB6618 433 - 433 aa - 433 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5828+/-0.000372; mu= 16.1691+/- 0.023
mean_var=80.5926+/-15.524, 0's: 0 Z-trim(114.0): 188 B-trim: 18 in 1/54
Lambda= 0.142865
statistics sampled from 23430 (23644) to 23430 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.277), width: 16
Scan time: 8.070
The best scores are: opt bits E(85289)
NP_002794 (OMIM: 154365) 26S protease regulatory s ( 433) 2856 598.5 1.1e-170
NP_001186092 (OMIM: 601681) 26S protease regulator ( 398) 1168 250.6 5.4e-66
NP_002796 (OMIM: 601681) 26S protease regulatory s ( 406) 1168 250.6 5.5e-66
NP_002797 (OMIM: 602708) 26S protease regulatory s ( 403) 1077 231.8 2.4e-60
NP_001317141 (OMIM: 602706) 26S protease regulator ( 367) 1050 226.3 1.1e-58
XP_016876959 (OMIM: 602706) PREDICTED: 26S proteas ( 367) 1050 226.3 1.1e-58
NP_002793 (OMIM: 602706) 26S protease regulatory s ( 440) 1050 226.3 1.2e-58
XP_016876961 (OMIM: 602708) PREDICTED: 26S proteas ( 288) 1020 220.0 6.3e-57
NP_002795 (OMIM: 186852) 26S protease regulatory s ( 439) 982 212.3 2e-54
NP_694546 (OMIM: 602707) 26S protease regulatory s ( 387) 973 210.4 6.6e-54
NP_006494 (OMIM: 602707) 26S protease regulatory s ( 418) 960 207.7 4.5e-53
XP_016873515 (OMIM: 186852) PREDICTED: 26S proteas ( 461) 934 202.4 2e-51
XP_005250562 (OMIM: 154365) PREDICTED: 26S proteas ( 141) 916 198.4 1e-50
NP_001191382 (OMIM: 154365) 26S protease regulator ( 141) 916 198.4 1e-50
XP_011523903 (OMIM: 604581,610246,614487) PREDICTE ( 730) 706 155.5 4e-37
NP_006787 (OMIM: 604581,610246,614487) AFG3-like p ( 797) 706 155.6 4.3e-37
NP_009057 (OMIM: 167320,601023,613954,616687) tran ( 806) 703 155.0 6.7e-37
XP_011515297 (OMIM: 611941) PREDICTED: ATPase fami ( 953) 647 143.5 2.3e-33
XP_011515296 (OMIM: 611941) PREDICTED: ATPase fami (1260) 647 143.5 2.9e-33
NP_054828 (OMIM: 611941) ATPase family AAA domain- (1390) 647 143.6 3.1e-33
XP_011531234 (OMIM: 615347) PREDICTED: ATPase fami ( 791) 636 141.1 9.5e-33
XP_011531233 (OMIM: 615347) PREDICTED: ATPase fami ( 837) 636 141.2 9.9e-33
XP_011531232 (OMIM: 615347) PREDICTED: ATPase fami ( 841) 636 141.2 1e-32
XP_011531231 (OMIM: 615347) PREDICTED: ATPase fami ( 843) 636 141.2 1e-32
XP_011531230 (OMIM: 615347) PREDICTED: ATPase fami ( 849) 636 141.2 1e-32
XP_006712094 (OMIM: 615347) PREDICTED: ATPase fami (1067) 636 141.2 1.2e-32
XP_011531227 (OMIM: 615347) PREDICTED: ATPase fami (1079) 636 141.2 1.2e-32
XP_011531226 (OMIM: 615347) PREDICTED: ATPase fami (1083) 636 141.2 1.2e-32
NP_001229267 (OMIM: 615347) ATPase family AAA doma (1453) 636 141.3 1.5e-32
NP_060022 (OMIM: 615347) ATPase family AAA domain- (1458) 636 141.3 1.5e-32
XP_006712093 (OMIM: 615347) PREDICTED: ATPase fami (1460) 636 141.3 1.5e-32
XP_011531223 (OMIM: 615347) PREDICTED: ATPase fami (1467) 636 141.3 1.6e-32
XP_005264429 (OMIM: 615347) PREDICTED: ATPase fami (1472) 636 141.3 1.6e-32
XP_016859864 (OMIM: 615347) PREDICTED: ATPase fami (1492) 636 141.3 1.6e-32
XP_011531222 (OMIM: 615347) PREDICTED: ATPase fami (1497) 636 141.3 1.6e-32
XP_011531221 (OMIM: 615347) PREDICTED: ATPase fami (1506) 636 141.3 1.6e-32
XP_011531220 (OMIM: 615347) PREDICTED: ATPase fami (1511) 636 141.3 1.6e-32
NP_003110 (OMIM: 602783,607259) paraplegin isoform ( 795) 622 138.3 7e-32
XP_006721327 (OMIM: 602783,607259) PREDICTED: para ( 809) 622 138.3 7.1e-32
XP_016879086 (OMIM: 602783,607259) PREDICTED: para ( 618) 618 137.4 1e-31
XP_016879087 (OMIM: 602783,607259) PREDICTED: para ( 561) 613 136.3 1.9e-31
NP_001240795 (OMIM: 607472) ATP-dependent zinc met ( 683) 588 131.2 8e-30
NP_055078 (OMIM: 607472) ATP-dependent zinc metall ( 716) 588 131.2 8.3e-30
XP_011517602 (OMIM: 607472) PREDICTED: ATP-depende ( 740) 588 131.2 8.5e-30
NP_647473 (OMIM: 607472) ATP-dependent zinc metall ( 773) 588 131.2 8.9e-30
NP_001304728 (OMIM: 613940,616577) spermatogenesis ( 695) 554 124.2 1e-27
XP_011529981 (OMIM: 613940,616577) PREDICTED: sper ( 790) 554 124.2 1.2e-27
XP_016863317 (OMIM: 613940,616577) PREDICTED: sper ( 819) 554 124.3 1.2e-27
NP_001332785 (OMIM: 613940,616577) spermatogenesis ( 892) 554 124.3 1.3e-27
NP_660208 (OMIM: 613940,616577) spermatogenesis-as ( 893) 554 124.3 1.3e-27
>>NP_002794 (OMIM: 154365) 26S protease regulatory subun (433 aa)
initn: 2856 init1: 2856 opt: 2856 Z-score: 3185.6 bits: 598.5 E(85289): 1.1e-170
Smith-Waterman score: 2856; 100.0% identity (100.0% similar) in 433 aa overlap (1-433:1-433)
10 20 30 40 50 60
pF1KB6 MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKIN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 ELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 FVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 IGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTML
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 ELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHAR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 SMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSY
370 380 390 400 410 420
430
pF1KB6 AKFSATPRYMTYN
:::::::::::::
NP_002 AKFSATPRYMTYN
430
>>NP_001186092 (OMIM: 601681) 26S protease regulatory su (398 aa)
initn: 1149 init1: 1149 opt: 1168 Z-score: 1305.8 bits: 250.6 E(85289): 5.4e-66
Smith-Waterman score: 1168; 50.8% identity (73.9% similar) in 372 aa overlap (53-418:14-384)
30 40 50 60 70
pF1KB6 RALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGI---KESDTGLAPPALWD
: :.::.:: : : .. .
NP_001 MELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNE
10 20 30 40
80 90 100 110 120 130
pF1KB6 LAADKQTLQSEQPL---QVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEE
: : . :. : : : . ... : . : ...:. .:::::.. .. .:.
NP_001 LNAKVRLLREELQLLQEQGSYVGEVVRA-MDKKKVLVKVHPEGKFVVDVDKNIDINDVTP
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB6 GMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLL
. ::.. ..: .: :: :.:: :..:.::. :: :: .:: .::....::.: :.
NP_001 NCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVK
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB6 HPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARM
::: : ::: ::::::.::::::::: :::::..:: :::: :::::::..::::::
NP_001 HPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARM
170 180 190 200 210 220
260 270 280 290 300 310
pF1KB6 VRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIK
::::: ::: . .::.::::.::..:.. :.:::.:::::::::.::::::. :::
NP_001 VRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIK
230 240 250 260 270 280
320 330 340 350 360 370
pF1KB6 VLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARL
:.::::: : :: ::.::::.:::::: :. :.: :.:::.:.:.. : : .. .:.:
NP_001 VIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAEL
290 300 310 320 330 340
380 390 400 410 420 430
pF1KB6 CPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
:...:::...:::::::.:.: :: .:..:: :: ::..
NP_001 MPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
350 360 370 380 390
>>NP_002796 (OMIM: 601681) 26S protease regulatory subun (406 aa)
initn: 1149 init1: 1149 opt: 1168 Z-score: 1305.7 bits: 250.6 E(85289): 5.5e-66
Smith-Waterman score: 1168; 50.8% identity (73.9% similar) in 372 aa overlap (53-418:22-392)
30 40 50 60 70
pF1KB6 RALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGI---KESDTGLAPPALWD
: :.::.:: : : .. .
NP_002 MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNE
10 20 30 40 50
80 90 100 110 120 130
pF1KB6 LAADKQTLQSEQPL---QVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEE
: : . :. : : : . ... : . : ...:. .:::::.. .. .:.
NP_002 LNAKVRLLREELQLLQEQGSYVGEVVRA-MDKKKVLVKVHPEGKFVVDVDKNIDINDVTP
60 70 80 90 100 110
140 150 160 170 180 190
pF1KB6 GMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLL
. ::.. ..: .: :: :.:: :..:.::. :: :: .:: .::....::.: :.
NP_002 NCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVK
120 130 140 150 160 170
200 210 220 230 240 250
pF1KB6 HPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARM
::: : ::: ::::::.::::::::: :::::..:: :::: :::::::..::::::
NP_002 HPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARM
180 190 200 210 220 230
260 270 280 290 300 310
pF1KB6 VRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIK
::::: ::: . .::.::::.::..:.. :.:::.:::::::::.::::::. :::
NP_002 VRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIK
240 250 260 270 280 290
320 330 340 350 360 370
pF1KB6 VLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARL
:.::::: : :: ::.::::.:::::: :. :.: :.:::.:.:.. : : .. .:.:
NP_002 VIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAEL
300 310 320 330 340 350
380 390 400 410 420 430
pF1KB6 CPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
:...:::...:::::::.:.: :: .:..:: :: ::..
NP_002 MPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
360 370 380 390 400
>>NP_002797 (OMIM: 602708) 26S protease regulatory subun (403 aa)
initn: 1104 init1: 1052 opt: 1077 Z-score: 1204.4 bits: 231.8 E(85289): 2.4e-60
Smith-Waterman score: 1078; 45.5% identity (75.1% similar) in 374 aa overlap (46-419:34-391)
20 30 40 50 60 70
pF1KB6 EKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPP
:... ...: ....::: :.. .
NP_002 PGIPYERRLLIMADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSEN----
10 20 30 40 50
80 90 100 110 120 130
pF1KB6 ALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIE
:: : ::: :.. .... .:. :.:... . ..:: :. . ..
NP_002 ---DLKA----LQSVG--QIV--GEVLKQLTEE-KFIVKATNGPRYVVGCRRQLDKSKLK
60 70 80 90 100
140 150 160 170 180 190
pF1KB6 EGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPL
: ::..: . : :: ..:: : :. :. .:.::..:: .:::..::::.: ::
NP_002 PGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPL
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB6 LHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGAR
.:: : .:: :::: ::.::::::::: :::::.. : :..:..: .:.::.::.::
NP_002 TNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESAR
170 180 190 200 210 220
260 270 280 290 300 310
pF1KB6 MVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNI
..::.:..:: .. :.::.:::::::: ::..:...: :.:::..::.::.:::: .
NP_002 LIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRV
230 240 250 260 270 280
320 330 340 350 360 370
pF1KB6 KVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLAR
:..:::::::::::::.:::::::::...::. ..: :.:::: .. . .: .: ...
NP_002 KMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVK
290 300 310 320 330 340
380 390 400 410 420 430
pF1KB6 LCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
: . .::..:.:::::::::::: . .....::..:: :: :
NP_002 LSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV
350 360 370 380 390 400
>>NP_001317141 (OMIM: 602706) 26S protease regulatory su (367 aa)
initn: 1022 init1: 1022 opt: 1050 Z-score: 1174.9 bits: 226.3 E(85289): 1.1e-58
Smith-Waterman score: 1050; 47.3% identity (76.2% similar) in 336 aa overlap (92-427:33-362)
70 80 90 100 110 120
pF1KB6 LTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKF
:..:. .:: .: . :.... ..
NP_001 EEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEII----DDNHAIVSTSVGSEH
10 20 30 40 50
130 140 150 160 170 180
pF1KB6 VVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCK
:.. . : .: : : .... . . : :: ::.:.::. :. ::.:.::
NP_001 YVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLD
60 70 80 90 100 110
190 200 210 220 230 240
pF1KB6 EQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVI
.::....: :: :: ::: . ..::.:::::.:.::::::::: :.::::.:.: :.::.
NP_001 NQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVV
120 130 140 150 160 170
250 260 270 280 290 300
pF1KB6 GSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLE
::::.:::.:.: ..:::::..:. . ..:.::::::: :.:...::. :.::::::
NP_001 GSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLE
180 190 200 210 220 230
310 320 330 340 350 360
pF1KB6 LINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARS
:.::::::: ::..::.::::: .::::::.::::.:::::: ::: . . .::.::.
NP_001 LLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSR
240 250 260 270 280 290
370 380 390 400 410 420
pF1KB6 MSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYA
:.. :. .. : . .::.:...:::::..:.: :: .:..:: .. ..:. :
NP_001 MTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVL--YK
300 310 320 330 340 350
430
pF1KB6 KFSATPRYMTYN
: .::
NP_001 KQEGTPEGLYL
360
>>XP_016876959 (OMIM: 602706) PREDICTED: 26S protease re (367 aa)
initn: 1022 init1: 1022 opt: 1050 Z-score: 1174.9 bits: 226.3 E(85289): 1.1e-58
Smith-Waterman score: 1050; 47.3% identity (76.2% similar) in 336 aa overlap (92-427:33-362)
70 80 90 100 110 120
pF1KB6 LTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKF
:..:. .:: .: . :.... ..
XP_016 EEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEII----DDNHAIVSTSVGSEH
10 20 30 40 50
130 140 150 160 170 180
pF1KB6 VVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCK
:.. . : .: : : .... . . : :: ::.:.::. :. ::.:.::
XP_016 YVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLD
60 70 80 90 100 110
190 200 210 220 230 240
pF1KB6 EQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVI
.::....: :: :: ::: . ..::.:::::.:.::::::::: :.::::.:.: :.::.
XP_016 NQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVV
120 130 140 150 160 170
250 260 270 280 290 300
pF1KB6 GSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLE
::::.:::.:.: ..:::::..:. . ..:.::::::: :.:...::. :.::::::
XP_016 GSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLE
180 190 200 210 220 230
310 320 330 340 350 360
pF1KB6 LINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARS
:.::::::: ::..::.::::: .::::::.::::.:::::: ::: . . .::.::.
XP_016 LLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSR
240 250 260 270 280 290
370 380 390 400 410 420
pF1KB6 MSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYA
:.. :. .. : . .::.:...:::::..:.: :: .:..:: .. ..:. :
XP_016 MTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVL--YK
300 310 320 330 340 350
430
pF1KB6 KFSATPRYMTYN
: .::
XP_016 KQEGTPEGLYL
360
>>NP_002793 (OMIM: 602706) 26S protease regulatory subun (440 aa)
initn: 1022 init1: 1022 opt: 1050 Z-score: 1173.8 bits: 226.3 E(85289): 1.2e-58
Smith-Waterman score: 1050; 47.3% identity (76.2% similar) in 336 aa overlap (92-427:106-435)
70 80 90 100 110 120
pF1KB6 LTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKF
:..:. .:: .: . :.... ..
NP_002 EEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEII----DDNHAIVSTSVGSEH
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB6 VVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCK
:.. . : .: : : .... . . : :: ::.:.::. :. ::.:.::
NP_002 YVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLD
140 150 160 170 180 190
190 200 210 220 230 240
pF1KB6 EQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVI
.::....: :: :: ::: . ..::.:::::.:.::::::::: :.::::.:.: :.::.
NP_002 NQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVV
200 210 220 230 240 250
250 260 270 280 290 300
pF1KB6 GSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLE
::::.:::.:.: ..:::::..:. . ..:.::::::: :.:...::. :.::::::
NP_002 GSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLE
260 270 280 290 300 310
310 320 330 340 350 360
pF1KB6 LINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARS
:.::::::: ::..::.::::: .::::::.::::.:::::: ::: . . .::.::.
NP_002 LLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSR
320 330 340 350 360 370
370 380 390 400 410 420
pF1KB6 MSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYA
:.. :. .. : . .::.:...:::::..:.: :: .:..:: .. ..:. :
NP_002 MTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVL--YK
380 390 400 410 420
430
pF1KB6 KFSATPRYMTYN
: .::
NP_002 KQEGTPEGLYL
430 440
>>XP_016876961 (OMIM: 602708) PREDICTED: 26S protease re (288 aa)
initn: 1068 init1: 1020 opt: 1020 Z-score: 1143.0 bits: 220.0 E(85289): 6.3e-57
Smith-Waterman score: 1020; 54.7% identity (83.1% similar) in 267 aa overlap (153-419:10-276)
130 140 150 160 170 180
pF1KB6 VDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKE
:: ..:: : :. :. .:.::..:: .:
XP_016 MTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSE
10 20 30
190 200 210 220 230 240
pF1KB6 QIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIG
::..::::.: :: .:: : .:: :::: ::.::::::::: :::::.. : :..:..
XP_016 QIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVS
40 50 60 70 80 90
250 260 270 280 290 300
pF1KB6 SELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLEL
: .:.::.::.::..::.:..:: .. :.::.:::::::: ::..:...: :.:::..::
XP_016 SSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMEL
100 110 120 130 140 150
310 320 330 340 350 360
pF1KB6 INQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSM
.::.:::: .:..:::::::::::::.:::::::::...::. ..: :.:::: .
XP_016 LNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPI
160 170 180 190 200 210
370 380 390 400 410 420
pF1KB6 SVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAK
. . .: .: ...: . .::..:.:::::::::::: . .....::..:: :: :
XP_016 TKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKL
220 230 240 250 260 270
430
pF1KB6 FSATPRYMTYN
XP_016 ESKLDYKPV
280
>>NP_002795 (OMIM: 186852) 26S protease regulatory subun (439 aa)
initn: 981 init1: 958 opt: 982 Z-score: 1098.0 bits: 212.3 E(85289): 2e-54
Smith-Waterman score: 984; 40.4% identity (66.6% similar) in 416 aa overlap (3-416:27-427)
10 20 30
pF1KB6 MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTY
: .: . : . .: .. : :: ..: ..:.
NP_002 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRT-RLLD-SEIKIMKS-
10 20 30 40 50
40 50 60 70 80 90
pF1KB6 GQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVA
.. .: ..: . ::.: .:. . .: :... : . .: .
NP_002 -------EVLRVTHELQAMKDKIKE-----NSEKIKVNKTLPYLVSNVIELLDVDPNDQE
60 70 80 90 100
100 110 120 130 140 150
pF1KB6 RCTKIINADSEDPKYIINVKQFAK--FVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLP
. :. ::. .: .. . . . : .. : :::....: : ::
NP_002 EDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLP
110 120 130 140 150 160
160 170 180 190 200 210
pF1KB6 PKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLL
. : : :.:.:.: :::.:: .::..: :.. :. : :.: ::::.::::::.
NP_002 TEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLM
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB6 FGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFF
.::::::::: ::: : .: : :... : .::: ..:.::..::. : .:. : .::.
NP_002 YGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFI
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB6 DEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRP
::.:::: :::. .:: :::::::::.::::::.: ..::. :::: : :::::.:
NP_002 DELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRS
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB6 GRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGM
::::::::: .:. :.:..:..::.:.:.: :. .: ::: . .::. ..::.::::
NP_002 GRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGM
350 360 370 380 390 400
400 410 420 430
pF1KB6 FAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
.:.: :..:..:.. .:
NP_002 IALRRGATELTHEDYMEGILEVQAKKKANLQYYA
410 420 430
>>NP_694546 (OMIM: 602707) 26S protease regulatory subun (387 aa)
initn: 955 init1: 955 opt: 973 Z-score: 1088.8 bits: 210.4 E(85289): 6.6e-54
Smith-Waterman score: 973; 42.5% identity (69.9% similar) in 379 aa overlap (45-418:8-377)
20 30 40 50 60 70
pF1KB6 DEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAP
.....:.: : . . ::. : : :
NP_694 MEEIGILVEKAQDEIPALSVSRPQ-TGL--SFLGPEP
10 20 30
80 90 100 110 120 130
pF1KB6 PALWDLAAD-KQTLQSEQ--PLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAP
: :: . :. .. : :: ... . .. .. :.. ... : . . .
NP_694 EDLEDLYSRYKEEVKRIQSIPLVIGQFLEAVDQNTA----IVGSTTGSNYYVRILSTIDR
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB6 TDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVV
.. . :.. ... . :::. : .. :. ..:::: :.:.:: : ...::.:
NP_694 ELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAV
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB6 ETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVG
: :: : : . ..::.::.:::..:::: :::. :.:::..: : ::::.:::.::::.:
NP_694 ELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLG
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB6 EGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDP
:: ::::..:..:. . .::.::::::. ::: .:.: :::: .:::.::.::::
NP_694 EGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQ
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB6 RGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFE
:.::.::::: :::::::.::::::::::: ::: . . ::. . .:.. ... .:
NP_694 NVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLE
280 290 300 310 320 330
380 390 400 410 420
pF1KB6 -LLARLCPNS-TGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRY
.:: :.. .::.: :.: :.::.:.: : :. ::: .: . :::
NP_694 DYVAR--PDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
340 350 360 370 380
430
pF1KB6 MTYN
433 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:07:33 2016 done: Sat Nov 5 11:07:34 2016
Total Scan time: 8.070 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]