Result of FASTA (omim) for
pFN21AB5955
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5955, 491 aa
1>>>pF1KB5955 491 - 491 aa - 491 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.0021+/-0.000676; mu= 3.0219+/- 0.040
mean_var=886.6936+/-204.892, 0's: 0 Z-trim(113.7): 1389 B-trim: 1478 in 1/56
Lambda= 0.043071
statistics sampled from 21304 (23110) to 21304 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.271), width: 16
Scan time: 8.480
The best scores are: opt bits E(85289)
XP_016868905 (OMIM: 165120) PREDICTED: tyrosine-pr ( 491) 3318 223.1 1.4e-57
NP_001104567 (OMIM: 165120) tyrosine-protein kinas ( 491) 3318 223.1 1.4e-57
NP_002341 (OMIM: 165120) tyrosine-protein kinase L ( 512) 3175 214.3 6.8e-55
XP_011515831 (OMIM: 165120) PREDICTED: tyrosine-pr ( 682) 3162 213.7 1.3e-54
NP_001165600 (OMIM: 142370) tyrosine-protein kinas ( 505) 2409 166.7 1.4e-40
NP_001165604 (OMIM: 142370) tyrosine-protein kinas ( 505) 2409 166.7 1.4e-40
NP_001165603 (OMIM: 142370) tyrosine-protein kinas ( 506) 2409 166.7 1.4e-40
NP_002101 (OMIM: 142370) tyrosine-protein kinase H ( 526) 2409 166.7 1.5e-40
NP_001165602 (OMIM: 142370) tyrosine-protein kinas ( 504) 2407 166.5 1.6e-40
NP_001165601 (OMIM: 142370) tyrosine-protein kinas ( 525) 2407 166.6 1.6e-40
NP_001036236 (OMIM: 153390,615758) tyrosine-protei ( 509) 2237 156.0 2.4e-37
NP_005347 (OMIM: 153390,615758) tyrosine-protein k ( 509) 2237 156.0 2.4e-37
NP_001706 (OMIM: 191305,613375) tyrosine-protein k ( 505) 2117 148.5 4.1e-35
NP_001317394 (OMIM: 191305,613375) tyrosine-protei ( 434) 2065 145.1 3.7e-34
XP_016881449 (OMIM: 164880) PREDICTED: tyrosine-pr ( 543) 1945 137.9 7e-32
NP_005424 (OMIM: 164880) tyrosine-protein kinase Y ( 543) 1945 137.9 7e-32
XP_016866143 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1929 136.9 1.4e-31
NP_002028 (OMIM: 137025) tyrosine-protein kinase F ( 537) 1929 136.9 1.4e-31
XP_016866141 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1929 136.9 1.4e-31
XP_016866142 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1929 136.9 1.4e-31
XP_016866139 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1929 136.9 1.4e-31
XP_016866140 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1929 136.9 1.4e-31
XP_016868904 (OMIM: 165120) PREDICTED: tyrosine-pr ( 499) 1892 134.5 6.7e-31
XP_005266947 (OMIM: 137025) PREDICTED: tyrosine-pr ( 534) 1888 134.3 8.1e-31
NP_694592 (OMIM: 137025) tyrosine-protein kinase F ( 534) 1888 134.3 8.1e-31
NP_938033 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1866 133.0 2.1e-30
XP_011527315 (OMIM: 114500,190090,616937) PREDICTE ( 536) 1866 133.0 2.1e-30
NP_005408 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1866 133.0 2.1e-30
XP_006710515 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 1857 132.4 3.1e-30
NP_001036194 (OMIM: 164940) tyrosine-protein kinas ( 529) 1857 132.4 3.1e-30
NP_005239 (OMIM: 164940) tyrosine-protein kinase F ( 529) 1857 132.4 3.1e-30
XP_011539312 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 1857 132.4 3.1e-30
NP_001036212 (OMIM: 164940) tyrosine-protein kinas ( 529) 1857 132.4 3.1e-30
XP_016883515 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1854 132.2 3.5e-30
XP_016883514 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1854 132.2 3.5e-30
XP_016883516 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1854 132.2 3.5e-30
XP_016883513 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1854 132.2 3.5e-30
XP_011533957 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1568 114.4 7.7e-25
XP_016866134 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1568 114.4 7.7e-25
XP_011533955 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1568 114.4 7.7e-25
XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1568 114.4 7.7e-25
NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 1568 114.4 7.7e-25
XP_005266939 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1568 114.4 7.7e-25
XP_005266938 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1568 114.4 7.7e-25
XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1568 114.4 7.7e-25
XP_011539313 (OMIM: 164940) PREDICTED: tyrosine-pr ( 460) 1480 108.8 3.3e-23
XP_005258196 (OMIM: 164880) PREDICTED: tyrosine-pr ( 499) 1455 107.4 1e-22
XP_011533958 (OMIM: 606573) PREDICTED: tyrosine-pr ( 392) 1399 103.7 1e-21
XP_016856162 (OMIM: 164940) PREDICTED: tyrosine-pr ( 325) 1351 100.5 7.5e-21
XP_011539316 (OMIM: 164940) PREDICTED: tyrosine-pr ( 325) 1351 100.5 7.5e-21
>>XP_016868905 (OMIM: 165120) PREDICTED: tyrosine-protei (491 aa)
initn: 3318 init1: 3318 opt: 3318 Z-score: 1154.7 bits: 223.1 E(85289): 1.4e-57
Smith-Waterman score: 3318; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:1-491)
10 20 30 40 50 60
pF1KB5 MGCIKSKGKDSLSDDGVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGCIKSKGKDSLSDDGVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 LSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 QLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 PCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 WMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 MAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 KIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 IPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY
430 440 450 460 470 480
490
pF1KB5 TATEGQYQQQP
:::::::::::
XP_016 TATEGQYQQQP
490
>>NP_001104567 (OMIM: 165120) tyrosine-protein kinase Ly (491 aa)
initn: 3318 init1: 3318 opt: 3318 Z-score: 1154.7 bits: 223.1 E(85289): 1.4e-57
Smith-Waterman score: 3318; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:1-491)
10 20 30 40 50 60
pF1KB5 MGCIKSKGKDSLSDDGVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGCIKSKGKDSLSDDGVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 LSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 QLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 PCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 WMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 MAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 KIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 IPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY
430 440 450 460 470 480
490
pF1KB5 TATEGQYQQQP
:::::::::::
NP_001 TATEGQYQQQP
490
>>NP_002341 (OMIM: 165120) tyrosine-protein kinase Lyn i (512 aa)
initn: 3173 init1: 3173 opt: 3175 Z-score: 1106.6 bits: 214.3 E(85289): 6.8e-55
Smith-Waterman score: 3266; 95.9% identity (95.9% similar) in 512 aa overlap (1-491:1-512)
10 20 30
pF1KB5 MGCIKSKGKDSLSDDGVDLKTQPV---------------------PESQLLPGQRFQTKD
:::::::::::::::::::::::: :::::::::::::::
NP_002 MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB5 PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB5 LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB5 KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB5 EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB5 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB5 KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB5 TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
430 440 450 460 470 480
460 470 480 490
pF1KB5 KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
::::::::::::::::::::::::::::::::
NP_002 KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
490 500 510
>>XP_011515831 (OMIM: 165120) PREDICTED: tyrosine-protei (682 aa)
initn: 3162 init1: 3162 opt: 3162 Z-score: 1101.3 bits: 213.7 E(85289): 1.3e-54
Smith-Waterman score: 3162; 98.7% identity (99.6% similar) in 474 aa overlap (18-491:209-682)
10 20 30 40
pF1KB5 MGCIKSKGKDSLSDDGVDLKTQPVPESQLLPGQRFQTKDPEEQGDIV
... . ::::::::::::::::::::::::
XP_011 QQPPHTQVLLGRPVAPPTLNSSHRGAPPPRNFHRERVPESQLLPGQRFQTKDPEEQGDIV
180 190 200 210 220 230
50 60 70 80 90 100
pF1KB5 VALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEE
240 250 260 270 280 290
110 120 130 140 150 160
pF1KB5 WFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSL
300 310 320 330 340 350
170 180 190 200 210 220
pF1KB5 DNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIK
360 370 380 390 400 410
230 240 250 260 270 280
pF1KB5 LVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAV
420 430 440 450 460 470
290 300 310 320 330 340
pF1KB5 VTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDL
480 490 500 510 520 530
350 360 370 380 390 400
pF1KB5 RAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWS
540 550 560 570 580 590
410 420 430 440 450 460
pF1KB5 FGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERP
600 610 620 630 640 650
470 480 490
pF1KB5 TFDYLQSVLDDFYTATEGQYQQQP
::::::::::::::::::::::::
XP_011 TFDYLQSVLDDFYTATEGQYQQQP
660 670 680
>>NP_001165600 (OMIM: 142370) tyrosine-protein kinase HC (505 aa)
initn: 1321 init1: 1262 opt: 2409 Z-score: 849.4 bits: 166.7 E(85289): 1.4e-40
Smith-Waterman score: 2427; 71.1% identity (87.0% similar) in 506 aa overlap (1-491:1-505)
10 20 30 40
pF1KB5 MGCIKSK----GKDSLSDDGVDLKTQ-----PVPESQLLPG-QRFQTKDP--EEQGD---
:::.::: : ...: .. . . : : : . :: . ... : .: :.
NP_001 MGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDI
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLET
:::::: :..:: .::::.::..: :::: ::::::.:: :.:::.:::::::....:::
NP_001 IVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLET
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 EEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIR
:::::: :.::::::::::::: :.:.::.::: :::.::::::.:: .::..::::::
NP_001 EEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIR
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 SLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRES
.:::::.::::: :: ..... ::.: ::::..: :.: ::::::.::::::::::
NP_001 TLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRES
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY
.:: :.:::::::::::. ::. :::::::.:::.:::.::: :::.::::::::::.:.
NP_001 LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLH
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR
::::.: :::::::.:::::::::::::::.: ::::::::::::::::.::..:::::
NP_001 AVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR
310 320 330 340 350
350 360 370 380 390 400
pF1KB5 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV
::::::.::: ::.:::::::::::::::::::::::::::::::::::::: :::::::
NP_001 DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE
:::::::.::::::.::::: .: .:. :: .:::::: ::::.:::.:: :::.. ::
NP_001 WSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEE
420 430 440 450 460 470
470 480 490
pF1KB5 RPTFDYLQSVLDDFYTATEGQYQQQP
::::.:.::::::::::::.::::::
NP_001 RPTFEYIQSVLDDFYTATESQYQQQP
480 490 500
>>NP_001165604 (OMIM: 142370) tyrosine-protein kinase HC (505 aa)
initn: 1321 init1: 1262 opt: 2409 Z-score: 849.4 bits: 166.7 E(85289): 1.4e-40
Smith-Waterman score: 2427; 71.1% identity (87.0% similar) in 506 aa overlap (1-491:1-505)
10 20 30 40
pF1KB5 MGCIKSK----GKDSLSDDGVDLKTQ-----PVPESQLLPG-QRFQTKDP--EEQGD---
:::.::: : ...: .. . . : : : . :: . ... : .: :.
NP_001 MGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDI
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLET
:::::: :..:: .::::.::..: :::: ::::::.:: :.:::.:::::::....:::
NP_001 IVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLET
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 EEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIR
:::::: :.::::::::::::: :.:.::.::: :::.::::::.:: .::..::::::
NP_001 EEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIR
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 SLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRES
.:::::.::::: :: ..... ::.: ::::..: :.: ::::::.::::::::::
NP_001 TLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRES
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY
.:: :.:::::::::::. ::. :::::::.:::.:::.::: :::.::::::::::.:.
NP_001 LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLH
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR
::::.: :::::::.:::::::::::::::.: ::::::::::::::::.::..:::::
NP_001 AVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR
310 320 330 340 350
350 360 370 380 390 400
pF1KB5 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV
::::::.::: ::.:::::::::::::::::::::::::::::::::::::: :::::::
NP_001 DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE
:::::::.::::::.::::: .: .:. :: .:::::: ::::.:::.:: :::.. ::
NP_001 WSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEE
420 430 440 450 460 470
470 480 490
pF1KB5 RPTFDYLQSVLDDFYTATEGQYQQQP
::::.:.::::::::::::.::::::
NP_001 RPTFEYIQSVLDDFYTATESQYQQQP
480 490 500
>>NP_001165603 (OMIM: 142370) tyrosine-protein kinase HC (506 aa)
initn: 1321 init1: 1262 opt: 2409 Z-score: 849.3 bits: 166.7 E(85289): 1.4e-40
Smith-Waterman score: 2427; 71.1% identity (87.0% similar) in 506 aa overlap (1-491:2-506)
10 20 30 40
pF1KB5 MGCIKSK----GKDSLSDDGVDLKTQ-----PVPESQLLPG-QRFQTKDP--EEQGD--
:::.::: : ...: .. . . : : : . :: . ... : .: :.
NP_001 MMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSED
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 -IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLE
:::::: :..:: .::::.::..: :::: ::::::.:: :.:::.:::::::....::
NP_001 IIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLE
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI
::::::: :.::::::::::::: :.:.::.::: :::.::::::.:: .::..:::::
NP_001 TEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKI
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRE
:.:::::.::::: :: ..... ::.: ::::..: :.: ::::::.:::::::::
NP_001 RTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRE
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 SIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRL
:.:: :.:::::::::::. ::. :::::::.:::.:::.::: :::.::::::::::.:
NP_001 SLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 YAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIH
.::::.: :::::::.:::::::::::::::.: ::::::::::::::::.::..::::
NP_001 HAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIH
310 320 330 340 350
350 360 370 380 390 400
pF1KB5 RDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSD
:::::::.::: ::.:::::::::::::::::::::::::::::::::::::: ::::::
NP_001 RDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSD
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 VWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAE
::::::::.::::::.::::: .: .:. :: .:::::: ::::.:::.:: :::.. :
NP_001 VWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPE
420 430 440 450 460 470
470 480 490
pF1KB5 ERPTFDYLQSVLDDFYTATEGQYQQQP
:::::.:.::::::::::::.::::::
NP_001 ERPTFEYIQSVLDDFYTATESQYQQQP
480 490 500
>>NP_002101 (OMIM: 142370) tyrosine-protein kinase HCK i (526 aa)
initn: 1321 init1: 1262 opt: 2409 Z-score: 849.2 bits: 166.7 E(85289): 1.5e-40
Smith-Waterman score: 2427; 71.1% identity (87.0% similar) in 506 aa overlap (1-491:22-526)
10 20 30
pF1KB5 MGCIKSK----GKDSLSDDGVDLKTQ-----PVPESQLL
:::.::: : ...: .. . . : : : .
NP_002 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
10 20 30 40 50 60
40 50 60 70 80
pF1KB5 PG-QRFQTKDP--EEQGD---IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSL
:: . ... : .: :. :::::: :..:: .::::.::..: :::: ::::::.::
NP_002 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
70 80 90 100 110 120
90 100 110 120 130 140
pF1KB5 LTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSF
:.:::.:::::::....::::::::: :.::::::::::::: :.:.::.::: :::.
NP_002 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB5 SLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKA
::::::.:: .::..::::::.:::::.::::: :: ..... ::.: ::::..:
NP_002 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB5 CISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQ
:.: ::::::.::::::::::.:: :.:::::::::::. ::. :::::::.:::.:::.
NP_002 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
250 260 270 280 290 300
270 280 290 300 310 320
pF1KB5 AFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLI
::: :::.::::::::::.:.::::.: :::::::.:::::::::::::::.: :::::
NP_002 AFLAEANVMKTLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLI
310 320 330 340 350
330 340 350 360 370 380
pF1KB5 DFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKF
:::::::::::.::..:::::::::::.::: ::.:::::::::::::::::::::::::
NP_002 DFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKF
360 370 380 390 400 410
390 400 410 420 430 440
pF1KB5 PIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRV
::::::::::::: ::::::::::::::.::::::.::::: .: .:. :: .::::::
NP_002 PIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP
420 430 440 450 460 470
450 460 470 480 490
pF1KB5 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
::::.:::.:: :::.. ::::::.:.::::::::::::.::::::
NP_002 ENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
480 490 500 510 520
>>NP_001165602 (OMIM: 142370) tyrosine-protein kinase HC (504 aa)
initn: 1321 init1: 1262 opt: 2407 Z-score: 848.7 bits: 166.5 E(85289): 1.6e-40
Smith-Waterman score: 2424; 71.3% identity (86.9% similar) in 505 aa overlap (1-491:1-504)
10 20 30 40
pF1KB5 MGCIKSK----GKDSLSDDGVDLKTQ-----PVPESQLLPG-QRFQTKDP---EEQGDI-
:::.::: : ...: .. . . : : : . :: . ... : : . ::
NP_001 MGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREGSEDII
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 VVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETE
::::: :..:: .::::.::..: :::: ::::::.:: :.:::.:::::::....::::
NP_001 VVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETE
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 EWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRS
::::: :.::::::::::::: :.:.::.::: :::.::::::.:: .::..::::::.
NP_001 EWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRT
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 LDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESI
:::::.::::: :: ..... ::.: ::::..: :.: ::::::.::::::::::.
NP_001 LDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESL
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 KLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYA
:: :.:::::::::::. ::. :::::::.:::.:::.::: :::.::::::::::.:.:
NP_001 KLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 VVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRD
:::.: :::::::.:::::::::::::::.: ::::::::::::::::.::..::::::
NP_001 VVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRD
310 320 330 340 350
350 360 370 380 390 400
pF1KB5 LRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVW
:::::.::: ::.:::::::::::::::::::::::::::::::::::::: ::::::::
NP_001 LRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVW
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 SFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEER
::::::.::::::.::::: .: .:. :: .:::::: ::::.:::.:: :::.. :::
NP_001 SFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEER
420 430 440 450 460 470
470 480 490
pF1KB5 PTFDYLQSVLDDFYTATEGQYQQQP
:::.:.::::::::::::.::::::
NP_001 PTFEYIQSVLDDFYTATESQYQQQP
480 490 500
>>NP_001165601 (OMIM: 142370) tyrosine-protein kinase HC (525 aa)
initn: 1321 init1: 1262 opt: 2407 Z-score: 848.6 bits: 166.6 E(85289): 1.6e-40
Smith-Waterman score: 2424; 71.3% identity (86.9% similar) in 505 aa overlap (1-491:22-525)
10 20 30
pF1KB5 MGCIKSK----GKDSLSDDGVDLKTQ-----PVPESQLL
:::.::: : ...: .. . . : : : .
NP_001 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
10 20 30 40 50 60
40 50 60 70 80
pF1KB5 PG-QRFQTKDP---EEQGDI-VVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLL
:: . ... : : . :: ::::: :..:: .::::.::..: :::: ::::::.::
NP_001 PGPNSHNSNTPGIREGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLA
70 80 90 100 110 120
90 100 110 120 130 140
pF1KB5 TKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFS
:.:::.:::::::....::::::::: :.::::::::::::: :.:.::.::: :::.:
NP_001 TRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYS
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB5 LSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKAC
:::::.:: .::..::::::.:::::.::::: :: ..... ::.: ::::..: :
NP_001 LSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPC
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB5 ISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQA
.: ::::::.::::::::::.:: :.:::::::::::. ::. :::::::.:::.:::.:
NP_001 MSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEA
250 260 270 280 290 300
270 280 290 300 310 320
pF1KB5 FLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLID
:: :::.::::::::::.:.::::.: :::::::.:::::::::::::::.: ::::::
NP_001 FLAEANVMKTLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
310 320 330 340 350
330 340 350 360 370 380
pF1KB5 FSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFP
::::::::::.::..:::::::::::.::: ::.::::::::::::::::::::::::::
NP_001 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
360 370 380 390 400 410
390 400 410 420 430 440
pF1KB5 IKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVE
:::::::::::: ::::::::::::::.::::::.::::: .: .:. :: .:::::: :
NP_001 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
420 430 440 450 460 470
450 460 470 480 490
pF1KB5 NCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
:::.:::.:: :::.. ::::::.:.::::::::::::.::::::
NP_001 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
480 490 500 510 520
491 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 10:45:16 2016 done: Sat Nov 5 10:45:18 2016
Total Scan time: 8.480 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]