Result of FASTA (omim) for
pFN21AB5815
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5815, 471 aa
1>>>pF1KB5815 471 - 471 aa - 471 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2609+/-0.000488; mu= 11.6191+/- 0.031
mean_var=324.9892+/-69.183, 0's: 0 Z-trim(117.8): 115 B-trim: 1806 in 1/58
Lambda= 0.071144
statistics sampled from 29926 (30059) to 29926 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.713), E-opt: 0.2 (0.352), width: 16
Scan time: 8.710
The best scores are: opt bits E(85289)
NP_001012496 (OMIM: 191318) splicing factor U2AF 6 ( 471) 3169 339.6 1.1e-92
NP_009210 (OMIM: 191318) splicing factor U2AF 65 k ( 475) 3151 337.7 4.1e-92
XP_011524712 (OMIM: 191318) PREDICTED: splicing fa ( 371) 2430 263.6 6.8e-70
XP_006723057 (OMIM: 191318) PREDICTED: splicing fa ( 311) 2039 223.3 7.5e-58
>>NP_001012496 (OMIM: 191318) splicing factor U2AF 65 kD (471 aa)
initn: 3169 init1: 3169 opt: 3169 Z-score: 1784.8 bits: 339.6 E(85289): 1.1e-92
Smith-Waterman score: 3169; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471)
10 20 30 40 50 60
pF1KB5 MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 RSKPLTRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSKPLTRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 APGNPVLAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGNPVLAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 NPSVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPSVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 GYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAKNATLSTINQTPVTLQVPGLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAKNATLSTINQTPVTLQVPGLM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 SSQVQMGGHPTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSQVQMGGHPTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGV
370 380 390 400 410 420
430 440 450 460 470
pF1KB5 EVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
430 440 450 460 470
>>NP_009210 (OMIM: 191318) splicing factor U2AF 65 kDa s (475 aa)
initn: 3155 init1: 2295 opt: 3151 Z-score: 1774.8 bits: 337.7 E(85289): 4.1e-92
Smith-Waterman score: 3151; 99.2% identity (99.2% similar) in 475 aa overlap (1-471:1-475)
10 20 30 40 50 60
pF1KB5 MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 RSKPLTRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 RSKPLTRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 APGNPVLAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 APGNPVLAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 NPSVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 NPSVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSK
250 260 270 280 290 300
310 320 330 340 350
pF1KB5 GYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAKNATL----STINQTPVTLQV
:::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_009 GYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAKNATLVSPPSTINQTPVTLQV
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 PGLMSSQVQMGGHPTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 PGLMSSQVQMGGHPTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRP
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 VDGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 VDGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
430 440 450 460 470
>>XP_011524712 (OMIM: 191318) PREDICTED: splicing factor (371 aa)
initn: 2434 init1: 1574 opt: 2430 Z-score: 1375.8 bits: 263.6 E(85289): 6.8e-70
Smith-Waterman score: 2430; 98.9% identity (98.9% similar) in 371 aa overlap (105-471:1-371)
80 90 100 110 120 130
pF1KB5 GLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGLAVTP
::::::::::::::::::::::::::::::
XP_011 MQYKAMQAAGQIPATALLPTMTPDGLAVTP
10 20 30
140 150 160 170 180 190
pF1KB5 TPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQD
40 50 60 70 80 90
200 210 220 230 240 250
pF1KB5 KNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVV
100 110 120 130 140 150
260 270 280 290 300 310
pF1KB5 PDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTD
160 170 180 190 200 210
320 330 340 350 360 370
pF1KB5 QAIAGLNGMQLGDKKLLVQRASVGAKNATL----STINQTPVTLQVPGLMSSQVQMGGHP
:::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_011 QAIAGLNGMQLGDKKLLVQRASVGAKNATLVSPPSTINQTPVTLQVPGLMSSQVQMGGHP
220 230 240 250 260 270
380 390 400 410 420 430
pF1KB5 TEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFV
280 290 300 310 320 330
440 450 460 470
pF1KB5 EFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
:::::::::::::::::::::::::::::::::::::::::
XP_011 EFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
340 350 360 370
>>XP_006723057 (OMIM: 191318) PREDICTED: splicing factor (311 aa)
initn: 2043 init1: 1183 opt: 2039 Z-score: 1159.6 bits: 223.3 E(85289): 7.5e-58
Smith-Waterman score: 2039; 98.7% identity (98.7% similar) in 311 aa overlap (165-471:1-311)
140 150 160 170 180 190
pF1KB5 TPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQD
::::::::::::::::::::::::::::::
XP_006 MMDFFNAQMRLGGLTQAPGNPVLAVQINQD
10 20 30
200 210 220 230 240 250
pF1KB5 KNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVV
40 50 60 70 80 90
260 270 280 290 300 310
pF1KB5 PDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTD
100 110 120 130 140 150
320 330 340 350 360 370
pF1KB5 QAIAGLNGMQLGDKKLLVQRASVGAKNATL----STINQTPVTLQVPGLMSSQVQMGGHP
:::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_006 QAIAGLNGMQLGDKKLLVQRASVGAKNATLVSPPSTINQTPVTLQVPGLMSSQVQMGGHP
160 170 180 190 200 210
380 390 400 410 420 430
pF1KB5 TEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFV
220 230 240 250 260 270
440 450 460 470
pF1KB5 EFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
:::::::::::::::::::::::::::::::::::::::::
XP_006 EFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
280 290 300 310
471 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 10:25:03 2016 done: Sat Nov 5 10:25:05 2016
Total Scan time: 8.710 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]