Result of FASTA (omim) for
pFN21AB8993
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8993, 401 aa
1>>>pF1KB8993 401 - 401 aa - 401 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4291+/-0.000352; mu= 12.4397+/- 0.022
mean_var=95.5240+/-19.886, 0's: 0 Z-trim(116.6): 31 B-trim: 1172 in 1/49
Lambda= 0.131225
statistics sampled from 27950 (27976) to 27950 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.68), E-opt: 0.2 (0.328), width: 16
Scan time: 8.700
The best scores are: opt bits E(85289)
NP_149099 (OMIM: 400029,415000) heat shock transcr ( 401) 2641 510.1 3.9e-144
XP_005262622 (OMIM: 400029,415000) PREDICTED: heat ( 323) 2104 408.4 1.3e-113
XP_016885574 (OMIM: 400029,415000) PREDICTED: heat ( 328) 2104 408.4 1.3e-113
NP_689797 (OMIM: 400029,415000) heat shock transcr ( 203) 1125 222.9 5.5e-58
NP_001230023 (OMIM: 140581) heat shock factor prot ( 230) 169 42.0 0.0018
NP_001129036 (OMIM: 140581) heat shock factor prot ( 518) 169 42.1 0.0037
NP_004497 (OMIM: 140581) heat shock factor protein ( 536) 169 42.1 0.0038
>>NP_149099 (OMIM: 400029,415000) heat shock transcripti (401 aa)
initn: 2641 init1: 2641 opt: 2641 Z-score: 2708.7 bits: 510.1 E(85289): 3.9e-144
Smith-Waterman score: 2641; 100.0% identity (100.0% similar) in 401 aa overlap (1-401:1-401)
10 20 30 40 50 60
pF1KB8 MAHVSSETQDVSPKDELTASEASTRSPLCEHTFPGDSDLRSMIEEHAFQVLSQGSLLESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 MAHVSSETQDVSPKDELTASEASTRSPLCEHTFPGDSDLRSMIEEHAFQVLSQGSLLESP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SYTVCVSEPDKDDDFLSLNFPRKLWKIVESDQFKSISWDENGTCIVINEELFKKEILETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 SYTVCVSEPDKDDDFLSLNFPRKLWKIVESDQFKSISWDENGTCIVINEELFKKEILETK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 APYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESSVLSKLKFYYNPNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 APYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESSVLSKLKFYYNPNF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 KRGYPQLLVRVKRRIGVKNASPISTLFNEDFNKKHFRAGANMENHNSALAAEASEESLFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 KRGYPQLLVRVKRRIGVKNASPISTLFNEDFNKKHFRAGANMENHNSALAAEASEESLFS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ASKNLNMPLTRESSVRQIIANSSVPIRSGFPPPSPSTSVGPSEQIATDQHAILNQLTTIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 ASKNLNMPLTRESSVRQIIANSSVPIRSGFPPPSPSTSVGPSEQIATDQHAILNQLTTIH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 MHSHSTYMQARGHIVNFITTTTSQYHIISPLQNGYFGLTVEPSAVPTRYPLVSVNEAPYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 MHSHSTYMQARGHIVNFITTTTSQYHIISPLQNGYFGLTVEPSAVPTRYPLVSVNEAPYR
310 320 330 340 350 360
370 380 390 400
pF1KB8 NMLPAGNPWLQMPTIADRSAAPHSRLALQPSPLDKYHPNYN
:::::::::::::::::::::::::::::::::::::::::
NP_149 NMLPAGNPWLQMPTIADRSAAPHSRLALQPSPLDKYHPNYN
370 380 390 400
>>XP_005262622 (OMIM: 400029,415000) PREDICTED: heat sho (323 aa)
initn: 2104 init1: 2104 opt: 2104 Z-score: 2160.7 bits: 408.4 E(85289): 1.3e-113
Smith-Waterman score: 2104; 100.0% identity (100.0% similar) in 320 aa overlap (82-401:4-323)
60 70 80 90 100 110
pF1KB8 SQGSLLESPSYTVCVSEPDKDDDFLSLNFPRKLWKIVESDQFKSISWDENGTCIVINEEL
::::::::::::::::::::::::::::::
XP_005 MLFRKLWKIVESDQFKSISWDENGTCIVINEEL
10 20 30
120 130 140 150 160 170
pF1KB8 FKKEILETKAPYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESSVLSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FKKEILETKAPYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESSVLSK
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB8 LKFYYNPNFKRGYPQLLVRVKRRIGVKNASPISTLFNEDFNKKHFRAGANMENHNSALAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKFYYNPNFKRGYPQLLVRVKRRIGVKNASPISTLFNEDFNKKHFRAGANMENHNSALAA
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB8 EASEESLFSASKNLNMPLTRESSVRQIIANSSVPIRSGFPPPSPSTSVGPSEQIATDQHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EASEESLFSASKNLNMPLTRESSVRQIIANSSVPIRSGFPPPSPSTSVGPSEQIATDQHA
160 170 180 190 200 210
300 310 320 330 340 350
pF1KB8 ILNQLTTIHMHSHSTYMQARGHIVNFITTTTSQYHIISPLQNGYFGLTVEPSAVPTRYPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILNQLTTIHMHSHSTYMQARGHIVNFITTTTSQYHIISPLQNGYFGLTVEPSAVPTRYPL
220 230 240 250 260 270
360 370 380 390 400
pF1KB8 VSVNEAPYRNMLPAGNPWLQMPTIADRSAAPHSRLALQPSPLDKYHPNYN
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSVNEAPYRNMLPAGNPWLQMPTIADRSAAPHSRLALQPSPLDKYHPNYN
280 290 300 310 320
>>XP_016885574 (OMIM: 400029,415000) PREDICTED: heat sho (328 aa)
initn: 2104 init1: 2104 opt: 2104 Z-score: 2160.6 bits: 408.4 E(85289): 1.3e-113
Smith-Waterman score: 2104; 100.0% identity (100.0% similar) in 320 aa overlap (82-401:9-328)
60 70 80 90 100 110
pF1KB8 SQGSLLESPSYTVCVSEPDKDDDFLSLNFPRKLWKIVESDQFKSISWDENGTCIVINEEL
::::::::::::::::::::::::::::::
XP_016 MALRHLVARKLWKIVESDQFKSISWDENGTCIVINEEL
10 20 30
120 130 140 150 160 170
pF1KB8 FKKEILETKAPYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESSVLSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKKEILETKAPYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESSVLSK
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB8 LKFYYNPNFKRGYPQLLVRVKRRIGVKNASPISTLFNEDFNKKHFRAGANMENHNSALAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKFYYNPNFKRGYPQLLVRVKRRIGVKNASPISTLFNEDFNKKHFRAGANMENHNSALAA
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB8 EASEESLFSASKNLNMPLTRESSVRQIIANSSVPIRSGFPPPSPSTSVGPSEQIATDQHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EASEESLFSASKNLNMPLTRESSVRQIIANSSVPIRSGFPPPSPSTSVGPSEQIATDQHA
160 170 180 190 200 210
300 310 320 330 340 350
pF1KB8 ILNQLTTIHMHSHSTYMQARGHIVNFITTTTSQYHIISPLQNGYFGLTVEPSAVPTRYPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILNQLTTIHMHSHSTYMQARGHIVNFITTTTSQYHIISPLQNGYFGLTVEPSAVPTRYPL
220 230 240 250 260 270
360 370 380 390 400
pF1KB8 VSVNEAPYRNMLPAGNPWLQMPTIADRSAAPHSRLALQPSPLDKYHPNYN
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSVNEAPYRNMLPAGNPWLQMPTIADRSAAPHSRLALQPSPLDKYHPNYN
280 290 300 310 320
>>NP_689797 (OMIM: 400029,415000) heat shock transcripti (203 aa)
initn: 1143 init1: 1125 opt: 1125 Z-score: 1162.1 bits: 222.9 E(85289): 5.5e-58
Smith-Waterman score: 1125; 98.9% identity (100.0% similar) in 174 aa overlap (1-174:1-174)
10 20 30 40 50 60
pF1KB8 MAHVSSETQDVSPKDELTASEASTRSPLCEHTFPGDSDLRSMIEEHAFQVLSQGSLLESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MAHVSSETQDVSPKDELTASEASTRSPLCEHTFPGDSDLRSMIEEHAFQVLSQGSLLESP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SYTVCVSEPDKDDDFLSLNFPRKLWKIVESDQFKSISWDENGTCIVINEELFKKEILETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 SYTVCVSEPDKDDDFLSLNFPRKLWKIVESDQFKSISWDENGTCIVINEELFKKEILETK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 APYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESSVLSKLKFYYNPNF
:::::::::::::::::::::::::::::::::::::::::::::::::::..:
NP_689 APYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESSVLSKIRFTKMKLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 KRGYPQLLVRVKRRIGVKNASPISTLFNEDFNKKHFRAGANMENHNSALAAEASEESLFS
NP_689 RSSTYENRYLCCNLHLKDESNYS
190 200
>>NP_001230023 (OMIM: 140581) heat shock factor protein (230 aa)
initn: 176 init1: 92 opt: 169 Z-score: 183.1 bits: 42.0 E(85289): 0.0018
Smith-Waterman score: 211; 29.4% identity (62.0% similar) in 187 aa overlap (80-259:10-179)
50 60 70 80 90 100
pF1KB8 VLSQGSLLESPSYTVCVSEPDKDDDFLSLNFPRKLWKIVESDQFKS-ISWDENG-TCIVI
: ::: .:: . . :.:..:: . .:.
NP_001 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVL
10 20 30
110 120 130 140 150 160
pF1KB8 NEELFKKEILETKAPYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESS
.:. : :::: : . :. . . :::::::.::: :. . . . ....:...
NP_001 DEQRFAKEIL----P-KYFKHNNMASFVRQLNMYGFRKVVH------IDSGIVKQERDGP
40 50 60 70 80
170 180 190 200 210 220
pF1KB8 VLSKLKFYYNPNFKRGYPQLLVRVKRRIGVKNASPISTLFNEDFNK---KHFRAGANMEN
: . .: ::.: .:: .::... .. . . .::..: . .. ..:.
NP_001 VE-----FQHPYFKQGQDDLLENIKRKVSSSKPEE-NKIRQEDLTKIISSAQKVQIKQET
90 100 110 120 130 140
230 240 250 260 270 280
pF1KB8 HNSALAAEASE-ESLFSASKNLNMPLTRESSV-RQIIANSSVPIRSGFPPPSPSTSVGPS
.: :. :: :::.. ..: .....: :.:.
NP_001 IESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQFIVTLVQNNQLVSLKRKRPLLL
150 160 170 180 190 200
290 300 310 320 330 340
pF1KB8 EQIATDQHAILNQLTTIHMHSHSTYMQARGHIVNFITTTTSQYHIISPLQNGYFGLTVEP
NP_001 NTNGAQKKNLFQHIVKEPTDNHHHKVIF
210 220 230
>>NP_001129036 (OMIM: 140581) heat shock factor protein (518 aa)
initn: 182 init1: 92 opt: 169 Z-score: 177.8 bits: 42.1 E(85289): 0.0037
Smith-Waterman score: 211; 29.4% identity (62.0% similar) in 187 aa overlap (80-259:10-179)
50 60 70 80 90 100
pF1KB8 VLSQGSLLESPSYTVCVSEPDKDDDFLSLNFPRKLWKIVESDQFKS-ISWDENG-TCIVI
: ::: .:: . . :.:..:: . .:.
NP_001 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVL
10 20 30
110 120 130 140 150 160
pF1KB8 NEELFKKEILETKAPYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESS
.:. : :::: : . :. . . :::::::.::: :. . . . ....:...
NP_001 DEQRFAKEIL----P-KYFKHNNMASFVRQLNMYGFRKVVH------IDSGIVKQERDGP
40 50 60 70 80
170 180 190 200 210 220
pF1KB8 VLSKLKFYYNPNFKRGYPQLLVRVKRRIGVKNASPISTLFNEDFNK---KHFRAGANMEN
: . .: ::.: .:: .::... .. . . .::..: . .. ..:.
NP_001 VE-----FQHPYFKQGQDDLLENIKRKVSSSKPEE-NKIRQEDLTKIISSAQKVQIKQET
90 100 110 120 130 140
230 240 250 260 270 280
pF1KB8 HNSALAAEASE-ESLFSASKNLNMPLTRESSV-RQIIANSSVPIRSGFPPPSPSTSVGPS
.: :. :: :::.. ..: .....: :.:.
NP_001 IESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQFIVTLVQNNQLVSLKRKRPLLL
150 160 170 180 190 200
290 300 310 320 330 340
pF1KB8 EQIATDQHAILNQLTTIHMHSHSTYMQARGHIVNFITTTTSQYHIISPLQNGYFGLTVEP
NP_001 NTNGAQKKNLFQHIVKEPTDNHHHKVPHSRTEGLKPRERISDDIIIYDVTDDNADEENIP
210 220 230 240 250 260
>>NP_004497 (OMIM: 140581) heat shock factor protein 2 i (536 aa)
initn: 182 init1: 92 opt: 169 Z-score: 177.5 bits: 42.1 E(85289): 0.0038
Smith-Waterman score: 211; 29.4% identity (62.0% similar) in 187 aa overlap (80-259:10-179)
50 60 70 80 90 100
pF1KB8 VLSQGSLLESPSYTVCVSEPDKDDDFLSLNFPRKLWKIVESDQFKS-ISWDENG-TCIVI
: ::: .:: . . :.:..:: . .:.
NP_004 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVL
10 20 30
110 120 130 140 150 160
pF1KB8 NEELFKKEILETKAPYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFLSEEKESS
.:. : :::: : . :. . . :::::::.::: :. . . . ....:...
NP_004 DEQRFAKEIL----P-KYFKHNNMASFVRQLNMYGFRKVVH------IDSGIVKQERDGP
40 50 60 70 80
170 180 190 200 210 220
pF1KB8 VLSKLKFYYNPNFKRGYPQLLVRVKRRIGVKNASPISTLFNEDFNK---KHFRAGANMEN
: . .: ::.: .:: .::... .. . . .::..: . .. ..:.
NP_004 VE-----FQHPYFKQGQDDLLENIKRKVSSSKPEE-NKIRQEDLTKIISSAQKVQIKQET
90 100 110 120 130 140
230 240 250 260 270 280
pF1KB8 HNSALAAEASE-ESLFSASKNLNMPLTRESSV-RQIIANSSVPIRSGFPPPSPSTSVGPS
.: :. :: :::.. ..: .....: :.:.
NP_004 IESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQFIVTLVQNNQLVSLKRKRPLLL
150 160 170 180 190 200
290 300 310 320 330 340
pF1KB8 EQIATDQHAILNQLTTIHMHSHSTYMQARGHIVNFITTTTSQYHIISPLQNGYFGLTVEP
NP_004 NTNGAQKKNLFQHIVKEPTDNHHHKVPHSRTEGLKPRERISDDIIIYDVTDDNADEENIP
210 220 230 240 250 260
401 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 16:54:22 2016 done: Fri Nov 4 16:54:24 2016
Total Scan time: 8.700 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]