Result of FASTA (omim) for
pFN21AB8891
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8891, 211 aa
1>>>pF1KB8891 211 - 211 aa - 211 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5706+/-0.000273; mu= 13.7894+/- 0.017
mean_var=84.5843+/-16.798, 0's: 0 Z-trim(120.5): 27 B-trim: 211 in 1/57
Lambda= 0.139453
statistics sampled from 35781 (35810) to 35781 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.783), E-opt: 0.2 (0.42), width: 16
Scan time: 5.950
The best scores are: opt bits E(85289)
NP_000505 (OMIM: 171300,209880,600837,613711) glia ( 211) 1441 298.7 4.7e-81
NP_001177397 (OMIM: 171300,209880,600837,613711) g ( 228) 1441 298.7 5e-81
XP_016864826 (OMIM: 171300,209880,600837,613711) P ( 185) 1097 229.4 2.9e-60
NP_954701 (OMIM: 171300,209880,600837,613711) glia ( 185) 1097 229.4 2.9e-60
NP_001177398 (OMIM: 171300,209880,600837,613711) g ( 202) 1097 229.4 3.1e-60
XP_011512332 (OMIM: 171300,209880,600837,613711) P ( 159) 1089 227.8 7.8e-60
NP_001265027 (OMIM: 171300,209880,600837,613711) g ( 159) 1089 227.8 7.8e-60
XP_011526343 (OMIM: 602018) PREDICTED: neurturin i ( 197) 336 76.3 3.7e-14
NP_004549 (OMIM: 602018) neurturin preproprotein [ ( 197) 336 76.3 3.7e-14
NP_476432 (OMIM: 603886) artemin isoform 1 preprop ( 220) 240 57.1 2.6e-08
NP_476431 (OMIM: 603886) artemin isoform 3 [Homo s ( 228) 240 57.1 2.7e-08
NP_001129687 (OMIM: 603886) artemin isoform 3 [Hom ( 228) 240 57.1 2.7e-08
NP_004149 (OMIM: 602921) persephin preproprotein [ ( 156) 230 54.9 8.2e-08
>>NP_000505 (OMIM: 171300,209880,600837,613711) glial ce (211 aa)
initn: 1441 init1: 1441 opt: 1441 Z-score: 1576.2 bits: 298.7 E(85289): 4.7e-81
Smith-Waterman score: 1441; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KB8 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR
130 140 150 160 170 180
190 200 210
pF1KB8 PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
:::::::::::::::::::::::::::::::
NP_000 PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
190 200 210
>>NP_001177397 (OMIM: 171300,209880,600837,613711) glial (228 aa)
initn: 1441 init1: 1441 opt: 1441 Z-score: 1575.7 bits: 298.7 E(85289): 5e-81
Smith-Waterman score: 1441; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:18-228)
10 20 30 40
pF1KB8 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRA
:::::::::::::::::::::::::::::::::::::::::::
NP_001 MQSLPNSNGAAAGRDFKMKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB8 PFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB8 RGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNL
130 140 150 160 170 180
170 180 190 200 210
pF1KB8 SRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
190 200 210 220
>>XP_016864826 (OMIM: 171300,209880,600837,613711) PREDI (185 aa)
initn: 1097 init1: 1097 opt: 1097 Z-score: 1202.9 bits: 229.4 E(85289): 2.9e-60
Smith-Waterman score: 1197; 87.2% identity (87.7% similar) in 211 aa overlap (1-211:1-185)
10 20 30 40 50 60
pF1KB8 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQ
:::::::::::::::::::::::: .:::::::::
XP_016 MKLWDVVAVCLVLLHTASAFPLPA--------------------------ANMPEDYPDQ
10 20 30
70 80 90 100 110 120
pF1KB8 FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB8 TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR
100 110 120 130 140 150
190 200 210
pF1KB8 PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
:::::::::::::::::::::::::::::::
XP_016 PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
160 170 180
>>NP_954701 (OMIM: 171300,209880,600837,613711) glial ce (185 aa)
initn: 1097 init1: 1097 opt: 1097 Z-score: 1202.9 bits: 229.4 E(85289): 2.9e-60
Smith-Waterman score: 1197; 87.2% identity (87.7% similar) in 211 aa overlap (1-211:1-185)
10 20 30 40 50 60
pF1KB8 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQ
:::::::::::::::::::::::: .:::::::::
NP_954 MKLWDVVAVCLVLLHTASAFPLPA--------------------------ANMPEDYPDQ
10 20 30
70 80 90 100 110 120
pF1KB8 FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB8 TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR
100 110 120 130 140 150
190 200 210
pF1KB8 PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
:::::::::::::::::::::::::::::::
NP_954 PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
160 170 180
>>NP_001177398 (OMIM: 171300,209880,600837,613711) glial (202 aa)
initn: 1097 init1: 1097 opt: 1097 Z-score: 1202.4 bits: 229.4 E(85289): 3.1e-60
Smith-Waterman score: 1197; 87.2% identity (87.7% similar) in 211 aa overlap (1-211:18-202)
10 20 30 40
pF1KB8 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRA
::::::::::::::::::::::::
NP_001 MQSLPNSNGAAAGRDFKMKLWDVVAVCLVLLHTASAFPLPA-------------------
10 20 30 40
50 60 70 80 90 100
pF1KB8 PFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENS
.::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------ANMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENS
50 60 70 80 90
110 120 130 140 150 160
pF1KB8 RGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNL
100 110 120 130 140 150
170 180 190 200 210
pF1KB8 SRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
160 170 180 190 200
>>XP_011512332 (OMIM: 171300,209880,600837,613711) PREDI (159 aa)
initn: 1089 init1: 1089 opt: 1089 Z-score: 1195.2 bits: 227.8 E(85289): 7.8e-60
Smith-Waterman score: 1089; 100.0% identity (100.0% similar) in 159 aa overlap (53-211:1-159)
30 40 50 60 70 80
pF1KB8 PAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQ
::::::::::::::::::::::::::::::
XP_011 MPEDYPDQFDDVMDFIQATIKRLKRSPDKQ
10 20 30
90 100 110 120 130 140
pF1KB8 MAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIF
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB8 RYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRK
100 110 120 130 140 150
210
pF1KB8 HSAKRCGCI
:::::::::
XP_011 HSAKRCGCI
>>NP_001265027 (OMIM: 171300,209880,600837,613711) glial (159 aa)
initn: 1089 init1: 1089 opt: 1089 Z-score: 1195.2 bits: 227.8 E(85289): 7.8e-60
Smith-Waterman score: 1089; 100.0% identity (100.0% similar) in 159 aa overlap (53-211:1-159)
30 40 50 60 70 80
pF1KB8 PAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQ
::::::::::::::::::::::::::::::
NP_001 MPEDYPDQFDDVMDFIQATIKRLKRSPDKQ
10 20 30
90 100 110 120 130 140
pF1KB8 MAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIF
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB8 RYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRK
100 110 120 130 140 150
210
pF1KB8 HSAKRCGCI
:::::::::
NP_001 HSAKRCGCI
>>XP_011526343 (OMIM: 602018) PREDICTED: neurturin isofo (197 aa)
initn: 322 init1: 156 opt: 336 Z-score: 375.1 bits: 76.3 E(85289): 3.7e-14
Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (98-211:87-197)
70 80 90 100 110 120
pF1KB8 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV
:.:. :...: : : : : ... :
XP_011 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD
..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..:
XP_011 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED
120 130 140 150 160 170
190 200 210
pF1KB8 DLSFLDDNLVYHILRKHSAKRCGCI
..:::: . :: ... ::..:.:.
XP_011 EVSFLDAHSRYHTVHELSARECACV
180 190
>>NP_004549 (OMIM: 602018) neurturin preproprotein [Homo (197 aa)
initn: 322 init1: 156 opt: 336 Z-score: 375.1 bits: 76.3 E(85289): 3.7e-14
Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (98-211:87-197)
70 80 90 100 110 120
pF1KB8 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV
:.:. :...: : : : : ... :
NP_004 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD
..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..:
NP_004 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED
120 130 140 150 160 170
190 200 210
pF1KB8 DLSFLDDNLVYHILRKHSAKRCGCI
..:::: . :: ... ::..:.:.
NP_004 EVSFLDAHSRYHTVHELSARECACV
180 190
>>NP_476432 (OMIM: 603886) artemin isoform 1 preproprote (220 aa)
initn: 252 init1: 129 opt: 240 Z-score: 270.1 bits: 57.1 E(85289): 2.6e-08
Smith-Waterman score: 246; 30.2% identity (53.0% similar) in 215 aa overlap (3-211:23-219)
10 20 30 40
pF1KB8 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGR
:: ..:. :.:: ... : .. : : :: :
NP_476 MELGLGGLSTLSHCPWPRQQPALWPTLAA-LALLSSVAEASLGSAPRSP-AP-------R
10 20 30 40 50
50 60 70 80 90
pF1KB8 RRAPFALSSDS-NMPEDYPDQF-DDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAA
. : .:.: . ..: .. . .: : ..::: .: : :.
NP_476 EGPPPVLASPAGHLPGGRTARWCSGRARRPPPQPSRPAPPPPAPPSALPRG--GRAARAG
60 70 80 90 100
100 110 120 130 140 150
pF1KB8 NPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDK
.: : :.. . ::: : . . : ::::... : . ::.::::: :.. .:
NP_476 GP------GSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDL
110 120 130 140 150 160
160 170 180 190 200 210
pF1KB8 ILKNLSRNRRLV----SDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
: .: : : :.: :::: .. .::.: : ... . . :: :::.
NP_476 SLASLLGAGALRPPPGSRPVSQPCCRPTRYEA-VSFMDVNSTWRTVDRLSATACGCLG
170 180 190 200 210 220
211 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 16:22:27 2016 done: Fri Nov 4 16:22:27 2016
Total Scan time: 5.950 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]