Result of FASTA (ccds) for
pFN21AB8353
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8353, 347 aa
1>>>pF1KB8353 347 - 347 aa - 347 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4038+/-0.000771; mu= 15.2934+/- 0.047
mean_var=59.2119+/-11.919, 0's: 0 Z-trim(107.1): 27 B-trim: 0 in 0/50
Lambda= 0.166675
statistics sampled from 9326 (9344) to 9326 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.287), width: 16
Scan time: 1.710
The best scores are: opt bits E(32554)
CCDS2615.1 HDAC11 gene_id:79885|Hs108|chr3 ( 347) 2316 565.1 2.9e-161
CCDS46760.1 HDAC11 gene_id:79885|Hs108|chr3 ( 296) 1605 394.1 7.5e-110
CCDS82738.1 HDAC11 gene_id:79885|Hs108|chr3 ( 268) 1224 302.5 2.6e-82
CCDS43493.2 HDAC2 gene_id:3066|Hs108|chr6 ( 488) 305 81.6 1.5e-15
CCDS360.1 HDAC1 gene_id:3065|Hs108|chr1 ( 482) 292 78.5 1.3e-14
CCDS14420.1 HDAC8 gene_id:55869|Hs108|chrX ( 377) 278 75.1 1.1e-13
CCDS4264.1 HDAC3 gene_id:8841|Hs108|chr5 ( 428) 241 66.2 5.6e-11
>>CCDS2615.1 HDAC11 gene_id:79885|Hs108|chr3 (347 aa)
initn: 2316 init1: 2316 opt: 2316 Z-score: 3008.6 bits: 565.1 E(32554): 2.9e-161
Smith-Waterman score: 2316; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347)
10 20 30 40 50 60
pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
250 260 270 280 290 300
310 320 330 340
pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
310 320 330 340
>>CCDS46760.1 HDAC11 gene_id:79885|Hs108|chr3 (296 aa)
initn: 1605 init1: 1605 opt: 1605 Z-score: 2085.7 bits: 394.1 E(32554): 7.5e-110
Smith-Waterman score: 1906; 92.8% identity (92.8% similar) in 319 aa overlap (29-347:1-296)
10 20 30 40 50 60
pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
::::::::::::::::::::::::::::::::
CCDS46 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
10 20 30
70 80 90 100 110 120
pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
:::::::::::::::::::::::: :::::::::::::
CCDS46 VEAREASEEDLLVVHTRRYLNELK-----------------------RKVLRPLRTQTGG
40 50 60
130 140 150 160 170 180
pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
70 80 90 100 110 120
190 200 210 220 230 240
pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
130 140 150 160 170 180
250 260 270 280 290 300
pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
190 200 210 220 230 240
310 320 330 340
pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
250 260 270 280 290
>>CCDS82738.1 HDAC11 gene_id:79885|Hs108|chr3 (268 aa)
initn: 1224 init1: 1224 opt: 1224 Z-score: 1591.3 bits: 302.5 E(32554): 2.6e-82
Smith-Waterman score: 1608; 77.2% identity (77.2% similar) in 347 aa overlap (1-347:1-268)
10 20 30 40 50 60
pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
::::::::::::::::::::::::
CCDS82 VEAREASEEDLLVVHTRRYLNELK------------------------------------
70 80
130 140 150 160 170 180
pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
:::::::::::::::::
CCDS82 -------------------------------------------FLFERVEGISRATIIDL
90 100
190 200 210 220 230 240
pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
110 120 130 140 150 160
250 260 270 280 290 300
pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
170 180 190 200 210 220
310 320 330 340
pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
230 240 250 260
>>CCDS43493.2 HDAC2 gene_id:3066|Hs108|chr6 (488 aa)
initn: 200 init1: 103 opt: 305 Z-score: 392.8 bits: 81.6 E(32554): 1.5e-15
Smith-Waterman score: 305; 27.4% identity (56.9% similar) in 288 aa overlap (35-307:29-307)
10 20 30 40 50 60
pF1KB8 TQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAR
::. . . :.: . : . . .
CCDS43 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 EASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPL----RTQTGG
.:. :.. :. .:.. :. :. ...: . : . :. : . .:::
CCDS43 KATAEEMTKYHSDEYIKFLR-SIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGG
60 70 80 90 100 110
130 140 150 160 170
pF1KB8 TIMAGKLAVER---GWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATI
.. :: . ..: :.: .::.:: ......::: ::.::: .: .. .:.
CCDS43 SV-AGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQRVLY
120 130 140 150 160 170
180 190 200 210 220
pF1KB8 IDLDAHQGNGHERDFMDDKRVYIMDVYNR-HIYPG-----DRFAKQAIRRKVELEW--GT
::.: :.:.: :. :. ::. .. .. . .:: : : .. :.. :
CCDS43 IDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGI
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB8 EDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMV
.:. : . . :.: .. . :..:: . :.: : ::::: .... : .: :.:
CCDS43 DDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVV----
240 250 260 270 280
290 300 310 320 330 340
pF1KB8 RGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
. .:.::. .::: :
CCDS43 KTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPS
290 300 310 320 330 340
>>CCDS360.1 HDAC1 gene_id:3065|Hs108|chr1 (482 aa)
initn: 185 init1: 103 opt: 292 Z-score: 375.9 bits: 78.5 E(32554): 1.3e-14
Smith-Waterman score: 292; 27.2% identity (56.8% similar) in 287 aa overlap (35-307:28-306)
10 20 30 40 50 60
pF1KB8 TQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAR
::. . . :.: . : . . .
CCDS36 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 EASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPL----RTQTGG
.:. :.. :. :.. :. :. ...: . : . :. : . .:::
CCDS36 KANAEEMTKYHSDDYIKFLR-SIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGG
60 70 80 90 100 110
130 140 150 160 170
pF1KB8 TIMAG-KLAVER-GWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATII
.. .. :: .. :.: .::.:: ......::: ::.::: .: .. .:. :
CCDS36 SVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQRVLYI
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB8 DLDAHQGNGHERDFMDDKRVYIMDVYNR-HIYPG-----DRFAKQAIRRKVE--LEWGTE
:.: :.:.: :. :. ::. .. .. . .:: : : .. :. :. : .
CCDS36 DIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGID
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB8 DDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVR
:. : . ..: .. :..:: . :.: : ::::: .... : .: :.: .
CCDS36 DESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFV----K
240 250 260 270 280
300 310 320 330 340
pF1KB8 GRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
. .:.::. .::: :
CCDS36 SFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSN
290 300 310 320 330 340
>>CCDS14420.1 HDAC8 gene_id:55869|Hs108|chrX (377 aa)
initn: 186 init1: 100 opt: 278 Z-score: 359.5 bits: 75.1 E(32554): 1.1e-13
Smith-Waterman score: 278; 26.6% identity (55.8% similar) in 312 aa overlap (17-310:16-313)
10 20 30 40 50
pF1KB8 MLHTTQLYQHVPETRWPI-VYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSM
:. .:::.: .: :. : : ..... : : : .:
CCDS14 MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKI-P----KRASMVHSLIEAYALHKQM
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 -LVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLP---NFLVQRKVLRPLR
.:. . :: :.. . :: ::..:. . . . : : . . . ..
CCDS14 RIVKPKVASMEEMATFHTDAYLQHLQ-KVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 TQTGGTIMAGKLAVERGW---AINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGI
. :.:: :.. .. : ::: .::.:: ..:...::: : .:.: : .. :
CCDS14 AIGGATITAAQCLID-GMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFE--
120 130 140 150 160 170
180 190 200 210 220
pF1KB8 SRATIIDLDAHQGNGHERDFMDDKRVYIMDV--YNRHIYPGDRFAKQAIRRK-------V
: .::: :.:.: : : ..:. ... .. ..:: .... : :
CCDS14 -RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNV
180 190 200 210 220
230 240 250 260 270 280
pF1KB8 ELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDE
.. : .:..: . : .:. : : .:: . :.: . :: . .....:.:: :
CCDS14 PIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGK---
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB8 LVFRMVRGRRVPILMVTSGGYQ-KRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLL
.... .. :.. .:::. :::
CCDS14 -CLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYV
290 300 310 320 330 340
>>CCDS4264.1 HDAC3 gene_id:8841|Hs108|chr5 (428 aa)
initn: 91 init1: 91 opt: 241 Z-score: 310.5 bits: 66.2 E(32554): 5.6e-11
Smith-Waterman score: 241; 24.6% identity (54.9% similar) in 293 aa overlap (35-307:22-301)
10 20 30 40 50 60
pF1KB8 TQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAR
::. . . . ... . : . .. .
CCDS42 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPY
10 20 30 40 50
70 80 90 100 110
pF1KB8 EASEEDLLVVHTRRYLNELKW-----------SFAVATITEIPPVIFLPNFLVQRKVLRP
.::..:. :.. :.. :. :. . .. . :: .:... .
CCDS42 QASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPV--FPGLFEFCSRYTG
60 70 80 90 100
120 130 140 150 160 170
pF1KB8 LRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGIS
: :.: . .:. ::: .::.:: .. ...::: ::...: .: ..
CCDS42 ASLQ-GATQLNNKIC---DIAINWAGGLHHAKKFEASGFCYVNDIVIGI---LELLKYHP
110 120 130 140 150 160
180 190 200 210 220
pF1KB8 RATIIDLDAHQGNGHERDFMDDKRVYIMDV--YNRHIYPG--DRFAKQAIRRK-----VE
:. ::.: :.:.: .. :. ::. .. :. ...:: : . : . :
CCDS42 RVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVP
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB8 LEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDEL
:. : .:. : . :.. .. . : .: . :.: : :::: ...: : . :
CCDS42 LRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRG---HGEC
230 240 250 260 270
290 300 310 320 330 340
pF1KB8 VFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPP
: ..:.. .:.:.. .::: :
CCDS42 V-EYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTL
280 290 300 310 320 330
347 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 12:00:54 2016 done: Fri Nov 4 12:00:54 2016
Total Scan time: 1.710 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]