FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8352, 693 aa 1>>>pF1KB8352 693 - 693 aa - 693 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.4827+/-0.00107; mu= -12.1215+/- 0.063 mean_var=471.3751+/-103.550, 0's: 0 Z-trim(116.1): 107 B-trim: 279 in 1/51 Lambda= 0.059073 statistics sampled from 16595 (16698) to 16595 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.792), E-opt: 0.2 (0.513), width: 16 Scan time: 3.290 The best scores are: opt bits E(32554) CCDS35444.1 IRAK1 gene_id:3654|Hs108|chrX ( 682) 2933 264.7 3.2e-70 CCDS14740.1 IRAK1 gene_id:3654|Hs108|chrX ( 712) 2933 264.7 3.3e-70 CCDS35443.1 IRAK1 gene_id:3654|Hs108|chrX ( 633) 2665 241.8 2.3e-63 CCDS33697.1 IRAK2 gene_id:3656|Hs108|chr3 ( 625) 705 74.8 4.3e-13 >>CCDS35444.1 IRAK1 gene_id:3654|Hs108|chrX (682 aa) initn: 3268 init1: 2929 opt: 2933 Z-score: 1374.2 bits: 264.7 E(32554): 3.2e-70 Smith-Waterman score: 4470; 94.2% identity (94.2% similar) in 708 aa overlap (1-693:1-682) 10 20 30 40 50 60 pF1KB8 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFGGWRRAAGGREARGL ::::::::::::::::::::::::::::::::::::::::::::: CCDS35 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQF--------------- 10 20 30 40 70 80 90 100 110 120 pF1KB8 LAPTPDAPRPAAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLR ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 -----------AALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLR 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 ARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 ARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 GPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 GPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSE 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 ELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 ELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB8 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB8 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB8 YIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 YIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQS 400 410 420 430 440 450 490 500 510 520 pF1KB8 TLQAGLAADAWAAPIAMQIYKKHL---------------GQLACCCLHRRAKRRPPMTQE :::::::::::::::::::::::: ::::::::::::::::::::: CCDS35 TLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQE 460 470 480 490 500 510 530 540 550 560 570 580 pF1KB8 NSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 NSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHL 520 530 540 550 560 570 590 600 610 620 630 640 pF1KB8 TPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 TPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINP 580 590 600 610 620 630 650 660 670 680 690 pF1KB8 ARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS :::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 ARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS 640 650 660 670 680 >>CCDS14740.1 IRAK1 gene_id:3654|Hs108|chrX (712 aa) initn: 4411 init1: 2929 opt: 2933 Z-score: 1373.9 bits: 264.7 E(32554): 3.3e-70 Smith-Waterman score: 4309; 90.2% identity (90.2% similar) in 725 aa overlap (1-680:1-699) 10 20 30 40 50 60 pF1KB8 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFGGWRRAAGGREARGL ::::::::::::::::::::::::::::::::::::::::::::: CCDS14 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQF--------------- 10 20 30 40 70 80 90 100 110 120 pF1KB8 LAPTPDAPRPAAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLR ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 -----------AALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLR 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 ARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 ARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 GPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 GPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSE 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 ELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 ELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB8 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB8 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB8 YIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 YIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQS 400 410 420 430 440 450 490 500 510 520 pF1KB8 TLQAGLAADAWAAPIAMQIYKKHL---------------GQLACCCLHRRAKRRPPMTQ- :::::::::::::::::::::::: :::::::::::::::::::: CCDS14 TLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQV 460 470 480 490 500 510 530 540 550 pF1KB8 -----------------------------ENSYVSSTGRAHSGAAPWQPLAAPSGASAQA ::::::::::::::::::::::::::::::: CCDS14 YERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQA 520 530 540 550 560 570 560 570 580 590 600 610 pF1KB8 AEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 AEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSG 580 590 600 610 620 630 620 630 640 650 660 670 pF1KB8 PGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 PGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPG 640 650 660 670 680 690 680 690 pF1KB8 LGLEQDRQGPEESDEFQS ::::: CCDS14 LGLEQDRQGPEESDEFQS 700 710 >>CCDS35443.1 IRAK1 gene_id:3654|Hs108|chrX (633 aa) initn: 4138 init1: 2656 opt: 2665 Z-score: 1251.2 bits: 241.8 E(32554): 2.3e-63 Smith-Waterman score: 4042; 88.7% identity (90.2% similar) in 693 aa overlap (1-693:1-633) 10 20 30 40 50 60 pF1KB8 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFGGWRRAAGGREARGL ::::::::::::::::::::::::::::::::::::::::::::: CCDS35 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQF--------------- 10 20 30 40 70 80 90 100 110 120 pF1KB8 LAPTPDAPRPAAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLR ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 -----------AALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLR 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 ARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 ARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 GPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 GPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSE 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 ELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 ELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB8 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB8 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB8 YIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQS :::::::::::::::::::::::::::::::::::::::: : :. :.. :. CCDS35 YIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYL---VYER-------LEKLQA 400 410 420 430 440 490 500 510 520 530 540 pF1KB8 TLQAGLAADAWAAPIAMQIYKKHLGQLACCCLHRRAKRRPPMTQENSYVSSTGRAHSGAA .. ::. . . :: :. :: ::::::::::::::::: CCDS35 VV-AGVPGHSEAAS----------------CI-------PPSPQENSYVSSTGRAHSGAA 450 460 470 480 550 560 570 580 590 600 pF1KB8 PWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 PWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAG 490 500 510 520 530 540 610 620 630 640 650 660 pF1KB8 CPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 CPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDG 550 560 570 580 590 600 670 680 690 pF1KB8 ALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS ::::::::::::::::::::::::::::::::: CCDS35 ALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS 610 620 630 >>CCDS33697.1 IRAK2 gene_id:3656|Hs108|chr3 (625 aa) initn: 648 init1: 194 opt: 705 Z-score: 348.5 bits: 74.8 E(32554): 4.3e-13 Smith-Waterman score: 787; 28.4% identity (55.3% similar) in 682 aa overlap (18-668:4-623) 10 20 30 40 50 60 pF1KB8 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFGGWRRAAGGREARGL ..:..: ::. . . :::: :: .: CCDS33 MACYIYQLPSWVLDDLCRNMDALSEWDWMEF--------------- 10 20 30 70 80 90 100 110 pF1KB8 LAPTPDAPRPAAALIVRDQTELRLCERSGQRTASV------LWPWINRNARVADLVHILT :. .. : :.:: .: .:. .: :: : :.: : .:: .: CCDS33 -----------ASYVITDLTQLRKI-KSMERVQGVSITRELLWWWGMRQATVQQLVDLLC 40 50 60 70 120 130 140 150 160 pF1KB8 HLQLLRARDIITAWHP-PA---PLPS-PGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFL .:.: :: .:: :.: : :.:. : .. :. . .:: . . : .:: CCDS33 RLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFP 80 90 100 110 120 130 170 180 190 200 210 220 pF1KB8 SPAFPGSQTHSGPELGLVP---SPASLWPPPPSPAPS----STKPGPESSVSLLQGARPF .:. ...:. : . : .: :: :. . : .. : :. .:: : : CCDS33 GPGSSPARAHQ-PAFLQPPEEDAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSL-AGDSLF 140 150 160 170 180 190 230 240 250 260 270 280 pF1KB8 PFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSF : .. ..: .:... ::..: :. :::. .. .. :.:.:.: .... : CCDS33 ---WSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFF 200 210 220 230 240 250 290 300 310 320 330 340 pF1KB8 LTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRL .:.. : :::.. :.:: :. ..: .. ::::.:::. : . :: ::::. CCDS33 QAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQG-GSDPLPWPQRV 260 270 280 290 300 310 350 360 370 380 390 400 pF1KB8 DILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSS .: : :...:: . .::...::::::::. :::::. .:.. .. :. . CCDS33 SICSGLLCAVEYLH--GLEIIHSNVKSSNVLLDQNLTPKLAH-PMAHLCPV--NKRSKYT 320 330 340 350 360 410 420 430 440 450 460 pF1KB8 MVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKD :. .:. .: . :::::..:..:.:. .: :: :.:. :.:.: :. .. . . :::: CCDS33 MM-KTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPV-YLKD 370 380 390 400 410 420 470 480 490 500 510 pF1KB8 LVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLGQL-----------ACCC :. . . ..: : .. .. .: . : .. .: :.: :: : CCDS33 LLLSDIPSSTASLCSRKTGVENVMAKE-----ICQKYLEKGAGRLPEDCAEALATAACLC 430 440 450 460 470 480 520 530 540 550 560 570 pF1KB8 LHRRAKRRPPMTQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDE :.:: . . : :.. ::. :. .:.:... :. . :. .... CCDS33 LRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDASS 490 500 510 520 530 540 580 590 600 610 620 pF1KB8 SLGGLSAALRSWHLTPSCPLDPAP--LREAGCPQGDTAGESSWGSGPGSRPTAVEGLALG : .:.: . :: : . . :: ..:...:. : : : : CCDS33 S---MSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEP---PQDV------ 550 560 570 580 630 640 650 660 670 680 pF1KB8 SSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESD . :: :: :..:..... ::.. .::..:. CCDS33 -----TETSWQIEINEAKRKLMENILLYKEEKVDSIELFGP 590 600 610 620 690 pF1KB8 EFQS 693 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 12:00:10 2016 done: Fri Nov 4 12:00:10 2016 Total Scan time: 3.290 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]