Result of FASTA (omim) for
pFN21AB8273
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8273, 277 aa
1>>>pF1KB8273 277 - 277 aa - 277 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4350+/-0.000392; mu= 13.7611+/- 0.024
mean_var=64.7117+/-12.959, 0's: 0 Z-trim(111.3): 30 B-trim: 0 in 0/54
Lambda= 0.159435
statistics sampled from 19791 (19820) to 19791 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.607), E-opt: 0.2 (0.232), width: 16
Scan time: 5.920
The best scores are: opt bits E(85289)
NP_002790 (OMIM: 604030) proteasome subunit beta t ( 277) 1801 423.2 2.6e-118
NP_002792 (OMIM: 176847) proteasome subunit beta t ( 273) 1086 258.8 8.2e-69
NP_002789 (OMIM: 600307) proteasome subunit beta t ( 239) 342 87.6 2.4e-17
NP_002791 (OMIM: 177045) proteasome subunit beta t ( 219) 316 81.6 1.4e-15
NP_001093250 (OMIM: 611137) proteasome subunit bet ( 300) 314 81.2 2.5e-15
NP_001257410 (OMIM: 600307) proteasome subunit bet ( 213) 309 80.0 4.2e-15
NP_002788 (OMIM: 600306) proteasome subunit beta t ( 263) 294 76.6 5.5e-14
NP_004150 (OMIM: 177046,256040) proteasome subunit ( 272) 284 74.3 2.8e-13
NP_683720 (OMIM: 177046,256040) proteasome subunit ( 276) 284 74.3 2.8e-13
NP_001124197 (OMIM: 600306) proteasome subunit bet ( 160) 202 55.3 8.4e-08
XP_005267928 (OMIM: 600306) PREDICTED: proteasome ( 169) 187 51.9 9.6e-07
NP_001138404 (OMIM: 600306) proteasome subunit bet ( 203) 187 51.9 1.1e-06
NP_002787 (OMIM: 602177) proteasome subunit beta t ( 264) 160 45.8 0.0001
NP_002783 (OMIM: 606607) proteasome subunit alpha ( 248) 159 45.5 0.00012
NP_002786 (OMIM: 602176) proteasome subunit beta t ( 205) 154 44.3 0.00022
NP_002784 (OMIM: 602017) proteasome subunit beta t ( 241) 150 43.4 0.00048
NP_001317605 (OMIM: 176846) proteasome subunit alp ( 261) 148 43.0 0.0007
NP_001096137 (OMIM: 176846) proteasome subunit alp ( 261) 148 43.0 0.0007
NP_002780 (OMIM: 176846) proteasome subunit alpha ( 261) 148 43.0 0.0007
>>NP_002790 (OMIM: 604030) proteasome subunit beta type- (277 aa)
initn: 1801 init1: 1801 opt: 1801 Z-score: 2245.1 bits: 423.2 E(85289): 2.6e-118
Smith-Waterman score: 1801; 100.0% identity (100.0% similar) in 277 aa overlap (1-277:1-277)
10 20 30 40 50 60
pF1KB8 MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT
190 200 210 220 230 240
250 260 270
pF1KB8 RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
:::::::::::::::::::::::::::::::::::::
NP_002 RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
250 260 270
>>NP_002792 (OMIM: 176847) proteasome subunit beta type- (273 aa)
initn: 1116 init1: 987 opt: 1086 Z-score: 1356.4 bits: 258.8 E(85289): 8.2e-69
Smith-Waterman score: 1086; 58.3% identity (86.5% similar) in 266 aa overlap (10-275:8-271)
10 20 30 40 50 60
pF1KB8 MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD
: :::::.::.::: :: . : :.:..:::::::::.:..::..::::
NP_002 MLKPALEPRGGFSFENCQRNASLERVLP--GLKVPHARKTGTTIAGLVFQDGVILGAD
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV
::::. :::::.: :::::.:.:::::::.:::..:::....:..:::.::::: :::.
NP_002 TRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV
:..:.:.: ::::::..::.:..::::.:::.::...:::: ..::....:::. ::.::
NP_002 TVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAV
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB8 FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT
.::.:.:.: : :..:. ::..:::..:::::.:.: :::.:. .:: . :..
NP_002 LEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVK
180 190 200 210 220 230
250 260 270
pF1KB8 RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
: :::. :::::::. . :: .:..:::::.:.
NP_002 RSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
240 250 260 270
>>NP_002789 (OMIM: 600307) proteasome subunit beta type- (239 aa)
initn: 336 init1: 259 opt: 342 Z-score: 432.4 bits: 87.6 E(85289): 2.4e-17
Smith-Waterman score: 342; 32.1% identity (65.2% similar) in 187 aa overlap (42-227:33-219)
20 30 40 50 60 70
pF1KB8 GGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVAD
::::: .: . :.:::::.:.: : .:.
NP_002 ATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIAN
10 20 30 40 50 60
80 90 100 110 120 130
pF1KB8 KNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLF
. .:. : :.:: .:.::::. ... .. .: .::. .. : : :: ..:.: .
NP_002 RVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCY
70 80 90 100 110 120
140 150 160 170 180 190
pF1KB8 RYQGYIGAALVLGGVDVT-GPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDME
::. . :.....: : : ..::. : . .. :::: .. . .: :
NP_002 RYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMT
130 140 150 160 170 180
200 210 220 230 240 250
pF1KB8 EEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKG
.:: .....:.: .. : .::. : : .:... ..
NP_002 KEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
190 200 210 220 230
260 270
pF1KB8 TTAVLTEKITPLEIEVLEETVQTMDTS
>>NP_002791 (OMIM: 177045) proteasome subunit beta type- (219 aa)
initn: 326 init1: 302 opt: 316 Z-score: 400.7 bits: 81.6 E(85289): 1.4e-15
Smith-Waterman score: 316; 29.2% identity (64.6% similar) in 195 aa overlap (36-227:11-204)
10 20 30 40 50 60
pF1KB8 VYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRK--TGTTIAGVVYKDGIVLGADTRA
::.. . ::::: .: . :.:.:.:.:.
NP_002 MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRV
10 20 30 40
70 80 90 100 110 120
pF1KB8 TEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTAN
. : .:... .:. . ::: .:.:::.. .... . .::::.. . : :..:
NP_002 SAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAA
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB8 RMLKQMLFRYQGYIGAALVLGGVDVT-GPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFE
..... ..:. ..: :...: : : ..:. : . :.. :::: .. .
NP_002 NVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLG-GMLTRQPFAIGGSGSTFIYGYVD
110 120 130 140 150
190 200 210 220 230 240
pF1KB8 DKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRL
..: : :: . ....::: .. : .::. : : .:. .:
NP_002 AAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
160 170 180 190 200 210
250 260 270
pF1KB8 GRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
>>NP_001093250 (OMIM: 611137) proteasome subunit beta ty (300 aa)
initn: 312 init1: 166 opt: 314 Z-score: 396.1 bits: 81.2 E(85289): 2.5e-15
Smith-Waterman score: 314; 29.6% identity (59.3% similar) in 216 aa overlap (5-218:18-225)
10 20 30 40
pF1KB8 MAAVSVYAPPVGGFSFD-NCRRNAVLEADFAKRGYKLPKVRKTGTTI
: . : .::.. .: .. :. .: .: . :::
NP_001 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQI----HGPRLAH----GTTT
10 20 30 40 50
50 60 70 80 90 100
pF1KB8 AGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNL
. .. :.. .::::.. : :: :. . .. .::.:: .... .:
NP_001 LAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQREL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB8 ELHSLSTGRLPRVVTANRMLKQMLFRYQGY-IGAALVLGGVDVTGPHLYSIYPHGSTDKL
.:. : :.:: :..: ..:. :. .:.: . .: .: : : .::.:. .: :. .
NP_001 RLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB8 PYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNK
..:::: :..:.. .: :: .:: :. :.: . : ::...::
NP_001 DIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESG
180 190 200 210 220 230
230 240 250 260 270
pF1KB8 LDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
NP_001 WEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSR
240 250 260 270 280 290
>>NP_001257410 (OMIM: 600307) proteasome subunit beta ty (213 aa)
initn: 284 init1: 240 opt: 309 Z-score: 392.2 bits: 80.0 E(85289): 4.2e-15
Smith-Waterman score: 309; 32.9% identity (64.6% similar) in 161 aa overlap (42-201:33-193)
20 30 40 50 60 70
pF1KB8 GGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVAD
::::: .: . :.:::::.:.: : .:.
NP_001 ATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIAN
10 20 30 40 50 60
80 90 100 110 120 130
pF1KB8 KNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLF
. .:. : :.:: .:.::::. ... .. .: .::. .. : : :: ..:.: .
NP_001 RVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCY
70 80 90 100 110 120
140 150 160 170 180 190
pF1KB8 RYQGYIGAALVLGGVDVT-GPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDME
::. . :.....: : : ..::. : . .. :::: .. . .: :
NP_001 RYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMT
130 140 150 160 170 180
200 210 220 230 240 250
pF1KB8 EEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKG
.:: .....:
NP_001 KEECLQFTANAFFFYPQLSLWPWSGMAPVEE
190 200 210
>>NP_002788 (OMIM: 600306) proteasome subunit beta type- (263 aa)
initn: 232 init1: 125 opt: 294 Z-score: 372.1 bits: 76.6 E(85289): 5.5e-14
Smith-Waterman score: 294; 28.8% identity (65.5% similar) in 177 aa overlap (43-218:59-235)
20 30 40 50 60 70
pF1KB8 GFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADK
::: . .. :....::.::: : .:..
NP_002 DLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQ
30 40 50 60 70 80
80 90 100 110 120 130
pF1KB8 NCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFR
. .:. :.: . :: ::: .. .:.. . ... : . . :..:...: .:...
NP_002 TVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQ
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB8 YQGY-IGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEE
:.:. .. . .. : : :: :: . .:. . ..::::. :..:.. . :.:
NP_002 YKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEV
150 160 170 180 190 200
200 210 220 230 240 250
pF1KB8 EEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGT
:.: .:. .:: . . : ::. ..:
NP_002 EQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
210 220 230 240 250 260
>>NP_004150 (OMIM: 177046,256040) proteasome subunit bet (272 aa)
initn: 240 init1: 137 opt: 284 Z-score: 359.4 bits: 74.3 E(85289): 2.8e-13
Smith-Waterman score: 284; 28.7% identity (63.5% similar) in 178 aa overlap (43-218:68-244)
20 30 40 50 60 70
pF1KB8 GFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADK
::: . .. :.. ..:.::. : ..
NP_004 SSGCPGLEPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISAL
40 50 60 70 80 90
80 90 100 110 120 130
pF1KB8 NCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFR
.:. :.: . .: ::: .. .:.... .:. : .:. : .:...:..:. .
NP_004 RVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQ
100 110 120 130 140 150
140 150 160 170 180 190
pF1KB8 YQGYIGAAL--VLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDME
:.: .: .. .. : : :: :: . ::. . . . :::. :..:... .::..
NP_004 YRG-MGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLS
160 170 180 190 200 210
200 210 220 230 240 250
pF1KB8 EEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKG
::: .: .::: . : ::. ...
NP_004 PEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
220 230 240 250 260 270
>>NP_683720 (OMIM: 177046,256040) proteasome subunit bet (276 aa)
initn: 217 init1: 137 opt: 284 Z-score: 359.3 bits: 74.3 E(85289): 2.8e-13
Smith-Waterman score: 284; 28.7% identity (63.5% similar) in 178 aa overlap (43-218:72-248)
20 30 40 50 60 70
pF1KB8 GFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADK
::: . .. :.. ..:.::. : ..
NP_683 LALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISAL
50 60 70 80 90 100
80 90 100 110 120 130
pF1KB8 NCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFR
.:. :.: . .: ::: .. .:.... .:. : .:. : .:...:..:. .
NP_683 RVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQ
110 120 130 140 150 160
140 150 160 170 180 190
pF1KB8 YQGYIGAAL--VLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDME
:.: .: .. .. : : :: :: . ::. . . . :::. :..:... .::..
NP_683 YRG-MGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLS
170 180 190 200 210 220
200 210 220 230 240 250
pF1KB8 EEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKG
::: .: .::: . : ::. ...
NP_683 PEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
230 240 250 260 270
>>NP_001124197 (OMIM: 600306) proteasome subunit beta ty (160 aa)
initn: 140 init1: 125 opt: 202 Z-score: 261.1 bits: 55.3 E(85289): 8.4e-08
Smith-Waterman score: 202; 28.2% identity (65.6% similar) in 131 aa overlap (89-218:2-132)
60 70 80 90 100 110
pF1KB8 ADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPR
:: ::: .. .:.. . ... : . .
NP_001 MAGGAADCSFWERLLARQCRIYELRNKERIS
10 20 30
120 130 140 150 160 170
pF1KB8 VVTANRMLKQMLFRYQGY-IGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAA
:..:...: .:...:.:. .. . .. : : :: :: . .:. . ..::::. :
NP_001 VAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYA
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB8 MAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNK
..:.. . :.: :.: .:. .:: . . : ::. ..:
NP_001 YGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADL
100 110 120 130 140 150
240 250 260 270
pF1KB8 KGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
NP_001 HEKYSGSTP
160
277 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 11:17:21 2016 done: Fri Nov 4 11:17:22 2016
Total Scan time: 5.920 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]