Result of FASTA (omim) for
pFN21AB8258
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8258, 239 aa
1>>>pF1KB8258 239 - 239 aa - 239 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7225+/-0.000363; mu= 17.2608+/- 0.022
mean_var=56.9435+/-11.428, 0's: 0 Z-trim(114.2): 30 B-trim: 521 in 1/51
Lambda= 0.169962
statistics sampled from 23874 (23904) to 23874 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.28), width: 16
Scan time: 5.270
The best scores are: opt bits E(85289)
NP_002789 (OMIM: 600307) proteasome subunit beta t ( 239) 1583 396.1 2.9e-110
NP_001257410 (OMIM: 600307) proteasome subunit bet ( 213) 1299 326.4 2.4e-89
NP_002791 (OMIM: 177045) proteasome subunit beta t ( 219) 879 223.4 2.5e-58
NP_001093250 (OMIM: 611137) proteasome subunit bet ( 300) 354 94.8 1.8e-19
NP_002788 (OMIM: 600306) proteasome subunit beta t ( 263) 343 92.0 1.1e-18
NP_002790 (OMIM: 604030) proteasome subunit beta t ( 277) 342 91.8 1.3e-18
NP_004150 (OMIM: 177046,256040) proteasome subunit ( 272) 331 89.1 8.4e-18
NP_683720 (OMIM: 177046,256040) proteasome subunit ( 276) 331 89.1 8.5e-18
NP_002792 (OMIM: 176847) proteasome subunit beta t ( 273) 328 88.4 1.4e-17
XP_005267928 (OMIM: 600306) PREDICTED: proteasome ( 169) 225 63.0 3.8e-10
NP_001138404 (OMIM: 600306) proteasome subunit bet ( 203) 222 62.3 7.4e-10
NP_002786 (OMIM: 602176) proteasome subunit beta t ( 205) 213 60.1 3.4e-09
NP_001124197 (OMIM: 600306) proteasome subunit bet ( 160) 205 58.0 1.1e-08
NP_002784 (OMIM: 602017) proteasome subunit beta t ( 241) 166 48.6 1.2e-05
NP_002785 (OMIM: 602175) proteasome subunit beta t ( 201) 151 44.9 0.00013
NP_001186708 (OMIM: 602175) proteasome subunit bet ( 176) 146 43.6 0.00027
NP_002787 (OMIM: 602177) proteasome subunit beta t ( 264) 143 43.0 0.00062
NP_002780 (OMIM: 176846) proteasome subunit alpha ( 261) 134 40.8 0.0028
NP_001096137 (OMIM: 176846) proteasome subunit alp ( 261) 134 40.8 0.0028
NP_001317605 (OMIM: 176846) proteasome subunit alp ( 261) 134 40.8 0.0028
>>NP_002789 (OMIM: 600307) proteasome subunit beta type- (239 aa)
initn: 1583 init1: 1583 opt: 1583 Z-score: 2100.5 bits: 396.1 E(85289): 2.9e-110
Smith-Waterman score: 1583; 100.0% identity (100.0% similar) in 239 aa overlap (1-239:1-239)
10 20 30 40 50 60
pF1KB8 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
130 140 150 160 170 180
190 200 210 220 230
pF1KB8 MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
190 200 210 220 230
>>NP_001257410 (OMIM: 600307) proteasome subunit beta ty (213 aa)
initn: 1299 init1: 1299 opt: 1299 Z-score: 1724.9 bits: 326.4 E(85289): 2.4e-89
Smith-Waterman score: 1299; 99.5% identity (100.0% similar) in 194 aa overlap (1-194:1-194)
10 20 30 40 50 60
pF1KB8 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
130 140 150 160 170 180
190 200 210 220 230
pF1KB8 MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
:::::::::::::.
NP_001 MTKEECLQFTANAFFFYPQLSLWPWSGMAPVEE
190 200 210
>>NP_002791 (OMIM: 177045) proteasome subunit beta type- (219 aa)
initn: 877 init1: 518 opt: 879 Z-score: 1168.2 bits: 223.4 E(85289): 2.5e-58
Smith-Waterman score: 879; 62.4% identity (89.1% similar) in 202 aa overlap (30-231:16-216)
10 20 30 40 50 60
pF1KB8 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
:: ::::::::.::::::.:.:::...: .
NP_002 MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAV
10 20 30 40
70 80 90 100 110 120
pF1KB8 ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
.::: :::.:.:.::.: ::::::.::::: ..::: .:.:::.::::: .::.. ...
NP_002 VNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNI
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB8 CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
:.::::: : ...:::: .::::::.. .:::..:: ::::::::..:::::::.:. :
NP_002 SYKYREDLSAHLMVAGWDQREGGQVYGT-LGGMLTRQPFAIGGSGSTFIYGYVDAAYKPG
110 120 130 140 150 160
190 200 210 220 230
pF1KB8 MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
:. ::: .::..:.:::: ::::::::: :..:. .::...:.::...:::
NP_002 MSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
170 180 190 200 210
>>NP_001093250 (OMIM: 611137) proteasome subunit beta ty (300 aa)
initn: 332 init1: 305 opt: 354 Z-score: 470.5 bits: 94.8 E(85289): 1.8e-19
Smith-Waterman score: 354; 32.7% identity (60.7% similar) in 214 aa overlap (9-219:23-234)
10 20 30 40
pF1KB8 MAATLLAARGAGPAPAWG--PEAFTPDWESREVSTGTTIMAVQFDG
:..: : : :..: : .. ::: .: .:
NP_001 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPR-LAHGTTTLAFRFRH
10 20 30 40 50
50 60 70 80 90 100
pF1KB8 GVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIEL
::. .::.:.. :::.: .. :. :.:.... ::..:: . .. .: .. ..
NP_001 GVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELRE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB8 NEPPLVHTAASLFKEMCYRYRE-DLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGG
.. : : .::.:.. : .:: :: .. . ::: . : ... : : .. .. :
NP_001 GQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWD-RSGPELFYVYSDGTRLQGDIFSVG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB8 SGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVL
::: : :: .: :: :. .: .. :.: : .::. ::: . : . ::: :
NP_001 SGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSR
180 190 200 210 220 230
230
pF1KB8 LGDQIPKFAVATLPPA
NP_001 SDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTE
240 250 260 270 280 290
>>NP_002788 (OMIM: 600306) proteasome subunit beta type- (263 aa)
initn: 318 init1: 262 opt: 343 Z-score: 456.7 bits: 92.0 E(85289): 1.1e-18
Smith-Waterman score: 343; 32.2% identity (60.0% similar) in 205 aa overlap (14-217:43-242)
10 20 30 40
pF1KB8 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFD
::.:: .:. . :. ::: .: .:
NP_002 VNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWG----VPEEPGIEMLHGTTTLAFKFR
20 30 40 50 60
50 60 70 80 90 100
pF1KB8 GGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIE
::...::::.:.:.:::.... :. :. .. .:.::: . .. : .. ..
NP_002 HGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELR
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB8 LNEPPLVHTAASLFKEMCYRYR-EDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIG
.: : .:..:. .: :.:. : : .: ::: . : : :. . .:..:
NP_002 NKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVG
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB8 GSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQV
::: : :: .: : . :. ... :. : ::. :::.. : . :.:
NP_002 -SGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVS
190 200 210 220 230 240
230
pF1KB8 LLGDQIPKFAVATLPPA
NP_002 SDNVADLHEKYSGSTP
250 260
>>NP_002790 (OMIM: 604030) proteasome subunit beta type- (277 aa)
initn: 336 init1: 259 opt: 342 Z-score: 455.1 bits: 91.8 E(85289): 1.3e-18
Smith-Waterman score: 342; 32.1% identity (65.2% similar) in 187 aa overlap (33-219:42-227)
10 20 30 40 50 60
pF1KB8 ATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIAN
::::: .: . :.:::::.:.: : .:.
NP_002 GGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVAD
20 30 40 50 60 70
70 80 90 100 110 120
pF1KB8 RVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCY
. .:. : :.:: .:.::::. ... .. .: .::. .. : : :: ..:.: .
NP_002 KNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLF
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB8 RYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMT
::. . :.....: : : ..::. : . .. :::: .. . .: :
NP_002 RYQGYIGAALVLGGVDVT-GPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDME
140 150 160 170 180 190
190 200 210 220 230
pF1KB8 KEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
.:: .....:.: .. : .::. : : .:... ..
NP_002 EEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKG
200 210 220 230 240 250
NP_002 TTAVLTEKITPLEIEVLEETVQTMDTS
260 270
>>NP_004150 (OMIM: 177046,256040) proteasome subunit bet (272 aa)
initn: 322 init1: 280 opt: 331 Z-score: 440.6 bits: 89.1 E(85289): 8.4e-18
Smith-Waterman score: 331; 32.8% identity (62.4% similar) in 189 aa overlap (30-217:64-251)
10 20 30 40 50
pF1KB8 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSY
:.. ::: .: .:. ::. ..:::...:::
NP_004 PTPVSSGCPGLEPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSY
40 50 60 70 80 90
60 70 80 90 100 110
pF1KB8 IANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKE
:. ..:. :. .. :: ::: : .. . .. .. .: : .:..:...
NP_004 ISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSN
100 110 120 130 140 150
120 130 140 150 160 170
pF1KB8 MCYRYR-EDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYR
: .:: : : .: ::: ..: .: : : . .. :::..: :: .:. ::
NP_004 MMCQYRGMGLSMGSMICGWD-KKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYR
160 170 180 190 200 210
180 190 200 210 220 230
pF1KB8 EGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPP
... :: .. :.: : .::. ::::. . . :.:
NP_004 PNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
220 230 240 250 260 270
pF1KB8 A
>>NP_683720 (OMIM: 177046,256040) proteasome subunit bet (276 aa)
initn: 322 init1: 280 opt: 331 Z-score: 440.5 bits: 89.1 E(85289): 8.5e-18
Smith-Waterman score: 331; 32.8% identity (62.4% similar) in 189 aa overlap (30-217:68-255)
10 20 30 40 50
pF1KB8 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSY
:.. ::: .: .:. ::. ..:::...:::
NP_683 RSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSY
40 50 60 70 80 90
60 70 80 90 100 110
pF1KB8 IANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKE
:. ..:. :. .. :: ::: : .. . .. .. .: : .:..:...
NP_683 ISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSN
100 110 120 130 140 150
120 130 140 150 160 170
pF1KB8 MCYRYR-EDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYR
: .:: : : .: ::: ..: .: : : . .. :::..: :: .:. ::
NP_683 MMCQYRGMGLSMGSMICGWD-KKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYR
160 170 180 190 200 210
180 190 200 210 220 230
pF1KB8 EGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPP
... :: .. :.: : .::. ::::. . . :.:
NP_683 PNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
220 230 240 250 260 270
pF1KB8 A
>>NP_002792 (OMIM: 176847) proteasome subunit beta type- (273 aa)
initn: 286 init1: 245 opt: 328 Z-score: 436.6 bits: 88.4 E(85289): 1.4e-17
Smith-Waterman score: 328; 29.9% identity (65.8% similar) in 187 aa overlap (33-219:38-223)
10 20 30 40 50 60
pF1KB8 ATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIAN
::::: .. :. ::.::::.:.:. : .:.
NP_002 PRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVAD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 RVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCY
. .:. : .:.:: .: :::.. .. :. .. .:.. .. : : :.. .... .
NP_002 KSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 RYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMT
::. . :..:..: : : :.:.: : . : :. :::.. . .. .. .::
NP_002 RYQGHVGASLIVGGVD-LTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMT
130 140 150 160 170 180
190 200 210 220 230
pF1KB8 KEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
: . ..:.. .. : .::: . .:...:..
NP_002 LEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPG
190 200 210 220 230 240
NP_002 TTAVLTQTVKPLTLELVEETVQAMEVE
250 260 270
>>XP_005267928 (OMIM: 600306) PREDICTED: proteasome subu (169 aa)
initn: 195 init1: 139 opt: 225 Z-score: 303.1 bits: 63.0 E(85289): 3.8e-10
Smith-Waterman score: 225; 32.8% identity (63.4% similar) in 131 aa overlap (14-143:43-169)
10 20 30 40
pF1KB8 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFD
::.:: .:. . :. ::: .: .:
XP_005 VNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWG----VPEEPGIEMLHGTTTLAFKFR
20 30 40 50 60
50 60 70 80 90 100
pF1KB8 GGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIE
::...::::.:.:.:::.... :. :. .. .:.::: . .. : .. ..
XP_005 HGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELR
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB8 LNEPPLVHTAASLFKEMCYRYR-EDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIG
.: : .:..:. .: :.:. : : .: ::: . :
XP_005 NKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPG
130 140 150 160
170 180 190 200 210 220
pF1KB8 GSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQV
239 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 11:06:06 2016 done: Fri Nov 4 11:06:07 2016
Total Scan time: 5.270 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]