Result of FASTA (omim) for
pFN21AB8180
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8180, 425 aa
1>>>pF1KB8180 425 - 425 aa - 425 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8762+/-0.000304; mu= 20.8408+/- 0.019
mean_var=87.4622+/-19.490, 0's: 0 Z-trim(117.8): 616 B-trim: 2925 in 2/55
Lambda= 0.137140
statistics sampled from 29406 (30183) to 29406 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.354), width: 16
Scan time: 7.340
The best scores are: opt bits E(85289)
XP_016856594 (OMIM: 602392) PREDICTED: orexin rece ( 425) 2860 575.7 7.7e-164
XP_016856595 (OMIM: 602392) PREDICTED: orexin rece ( 425) 2860 575.7 7.7e-164
NP_001516 (OMIM: 602392) orexin receptor type 1 [H ( 425) 2860 575.7 7.7e-164
XP_016856596 (OMIM: 602392) PREDICTED: orexin rece ( 389) 2466 497.7 2.1e-140
NP_001517 (OMIM: 602393) orexin receptor type 2 [H ( 444) 1892 384.2 3.6e-106
XP_016866287 (OMIM: 602393) PREDICTED: orexin rece ( 461) 1892 384.2 3.7e-106
NP_071429 (OMIM: 607448) neuropeptide FF receptor ( 430) 500 108.8 2.8e-23
NP_444264 (OMIM: 607449) neuropeptide FF receptor ( 420) 490 106.8 1.1e-22
NP_001138228 (OMIM: 607449) neuropeptide FF recept ( 423) 490 106.8 1.1e-22
NP_004876 (OMIM: 607449) neuropeptide FF receptor ( 522) 490 106.9 1.3e-22
NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 447 98.3 4.1e-20
XP_005263090 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 430 94.9 3.9e-19
NP_000901 (OMIM: 162642) neuropeptide Y receptor t ( 381) 430 94.9 3.9e-19
XP_005263091 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 430 94.9 3.9e-19
NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 427 94.2 5.7e-19
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 413 91.6 4.4e-18
NP_002502 (OMIM: 162341) neuromedin-B receptor iso ( 390) 411 91.1 5.3e-18
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 404 89.8 1.6e-17
NP_620414 (OMIM: 607122) prokineticin receptor 1 [ ( 393) 403 89.5 1.6e-17
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 403 89.7 2.1e-17
NP_000721 (OMIM: 118444) cholecystokinin receptor ( 428) 399 88.8 2.9e-17
NP_057624 (OMIM: 605569) probable G-protein couple ( 423) 388 86.6 1.3e-16
NP_658986 (OMIM: 244200,607123) prokineticin recep ( 384) 386 86.2 1.6e-16
XP_016883135 (OMIM: 244200,607123) PREDICTED: prok ( 384) 386 86.2 1.6e-16
XP_011527461 (OMIM: 244200,607123) PREDICTED: prok ( 348) 385 85.9 1.7e-16
NP_056542 (OMIM: 162323) substance-P receptor isof ( 311) 379 84.7 3.7e-16
NP_001049 (OMIM: 162323) substance-P receptor isof ( 407) 379 84.8 4.4e-16
NP_000900 (OMIM: 162641) neuropeptide Y receptor t ( 384) 378 84.6 4.8e-16
XP_011530312 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 378 84.6 4.8e-16
XP_005263088 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 378 84.6 4.8e-16
XP_005253267 (OMIM: 118445) PREDICTED: gastrin/cho ( 516) 373 83.7 1.2e-15
NP_795344 (OMIM: 118445) gastrin/cholecystokinin t ( 447) 368 82.7 2.1e-15
NP_001050 (OMIM: 162332,614840) neuromedin-K recep ( 465) 368 82.7 2.2e-15
NP_001048 (OMIM: 162321) substance-K receptor [Hom ( 398) 366 82.2 2.6e-15
NP_001304020 (OMIM: 602001) neuropeptide Y recepto ( 445) 366 82.3 2.8e-15
NP_006165 (OMIM: 602001) neuropeptide Y receptor t ( 445) 366 82.3 2.8e-15
XP_005263095 (OMIM: 602001) PREDICTED: neuropeptid ( 445) 366 82.3 2.8e-15
NP_001304021 (OMIM: 602001) neuropeptide Y recepto ( 445) 366 82.3 2.8e-15
XP_011530319 (OMIM: 602001) PREDICTED: neuropeptid ( 445) 366 82.3 2.8e-15
XP_016863745 (OMIM: 602001) PREDICTED: neuropeptid ( 452) 366 82.3 2.8e-15
XP_011530317 (OMIM: 602001) PREDICTED: neuropeptid ( 452) 366 82.3 2.8e-15
XP_016863744 (OMIM: 602001) PREDICTED: neuropeptid ( 452) 366 82.3 2.8e-15
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 360 81.0 5.8e-15
XP_016881180 (OMIM: 600377) PREDICTED: galanin rec ( 269) 358 80.4 5.9e-15
NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 358 80.6 7.1e-15
NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 356 80.2 9.8e-15
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 356 80.2 1e-14
NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 356 80.2 1e-14
XP_016864182 (OMIM: 606925) PREDICTED: pyroglutamy ( 190) 352 79.1 1.1e-14
NP_005305 (OMIM: 305670) gastrin-releasing peptide ( 384) 351 79.2 2e-14
>>XP_016856594 (OMIM: 602392) PREDICTED: orexin receptor (425 aa)
initn: 2860 init1: 2860 opt: 2860 Z-score: 3062.4 bits: 575.7 E(85289): 7.7e-164
Smith-Waterman score: 2860; 100.0% identity (100.0% similar) in 425 aa overlap (1-425:1-425)
10 20 30 40 50 60
pF1KB8 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
370 380 390 400 410 420
pF1KB8 TTVLP
:::::
XP_016 TTVLP
>>XP_016856595 (OMIM: 602392) PREDICTED: orexin receptor (425 aa)
initn: 2860 init1: 2860 opt: 2860 Z-score: 3062.4 bits: 575.7 E(85289): 7.7e-164
Smith-Waterman score: 2860; 100.0% identity (100.0% similar) in 425 aa overlap (1-425:1-425)
10 20 30 40 50 60
pF1KB8 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
370 380 390 400 410 420
pF1KB8 TTVLP
:::::
XP_016 TTVLP
>>NP_001516 (OMIM: 602392) orexin receptor type 1 [Homo (425 aa)
initn: 2860 init1: 2860 opt: 2860 Z-score: 3062.4 bits: 575.7 E(85289): 7.7e-164
Smith-Waterman score: 2860; 100.0% identity (100.0% similar) in 425 aa overlap (1-425:1-425)
10 20 30 40 50 60
pF1KB8 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
370 380 390 400 410 420
pF1KB8 TTVLP
:::::
NP_001 TTVLP
>>XP_016856596 (OMIM: 602392) PREDICTED: orexin receptor (389 aa)
initn: 2448 init1: 2448 opt: 2466 Z-score: 2641.6 bits: 497.7 E(85289): 2.1e-140
Smith-Waterman score: 2466; 96.6% identity (97.7% similar) in 384 aa overlap (1-382:1-381)
10 20 30 40 50 60
pF1KB8 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
310 320 330 340 350 360
370 380 390 400 410
pF1KB8 LSGKFREQFKAAFSC--CLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLT
::: .:. . :.:: : :: :
XP_016 LSG-CKEK-SLALSCPSC-PGHDPHLAAALCS
370 380
>>NP_001517 (OMIM: 602393) orexin receptor type 2 [Homo (444 aa)
initn: 1853 init1: 1261 opt: 1892 Z-score: 2027.1 bits: 384.2 E(85289): 3.6e-106
Smith-Waterman score: 1892; 69.2% identity (85.6% similar) in 416 aa overlap (17-425:24-433)
10 20 30 40 50
pF1KB8 MEPSATPGAQMGVPPGSREPSPVPPDYEDE-FLRYLWRDYLYPKQYEWVLIAA
..:: : ::.:: :::::::.::.::.:::::::.
NP_001 MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 YVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESW
:. ::::::.::.:::.:::.::::::::::::::::::::::: ::::.:.:::::.:
NP_001 YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB8 LFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVS
.::..:::::::::.:::::.::::: :::::::::::::.:::::.:::.::. :: ::
NP_001 FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB8 LAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMA
::.::: :::::.:.: :::.: ::.::::::. ..:::.:: :::.:::.::: ::.
NP_001 CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
190 200 210 220 230 240
240 250 260 270 280
pF1KB8 MAYFQIFRKLWGRQIPGTTSALVRNWK--RPSDQLGDLEQGLSGEP-QPRARAFLAEVKQ
.::.::::::: ::::::.:.. :.:: .: .: .: :.: . : : ::.::
NP_001 LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQ----PRG-PGQPTKSRMSAVAAEIKQ
250 260 270 280 290
290 300 310 320 330 340
pF1KB8 MRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYA
.:::::::.:::.::::::.::::::.::::::::::: .. :::.::: ::::::::::
NP_001 IRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB8 NSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSA-SHKSLSLQSRC--
::::::::::::::::::.:::::::: :. . :.:. :.:::. :
NP_001 NSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFD
360 370 380 390 400 410
410 420
pF1KB8 SISKISEHVVLTSVTTVLP
.:::.::.:::::..: ::
NP_001 NISKLSEQVVLTSIST-LPAANGAGPLQNW
420 430 440
>>XP_016866287 (OMIM: 602393) PREDICTED: orexin receptor (461 aa)
initn: 1853 init1: 1261 opt: 1892 Z-score: 2026.9 bits: 384.2 E(85289): 3.7e-106
Smith-Waterman score: 1892; 69.2% identity (85.6% similar) in 416 aa overlap (17-425:24-433)
10 20 30 40 50
pF1KB8 MEPSATPGAQMGVPPGSREPSPVPPDYEDE-FLRYLWRDYLYPKQYEWVLIAA
..:: : ::.:: :::::::.::.::.:::::::.
XP_016 MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 YVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESW
:. ::::::.::.:::.:::.::::::::::::::::::::::: ::::.:.:::::.:
XP_016 YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB8 LFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVS
.::..:::::::::.:::::.::::: :::::::::::::.:::::.:::.::. :: ::
XP_016 FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB8 LAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMA
::.::: :::::.:.: :::.: ::.::::::. ..:::.:: :::.:::.::: ::.
XP_016 CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
190 200 210 220 230 240
240 250 260 270 280
pF1KB8 MAYFQIFRKLWGRQIPGTTSALVRNWK--RPSDQLGDLEQGLSGEP-QPRARAFLAEVKQ
.::.::::::: ::::::.:.. :.:: .: .: .: :.: . : : ::.::
XP_016 LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQ----PRG-PGQPTKSRMSAVAAEIKQ
250 260 270 280 290
290 300 310 320 330 340
pF1KB8 MRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYA
.:::::::.:::.::::::.::::::.::::::::::: .. :::.::: ::::::::::
XP_016 IRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB8 NSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSA-SHKSLSLQSRC--
::::::::::::::::::.:::::::: :. . :.:. :.:::. :
XP_016 NSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFD
360 370 380 390 400 410
410 420
pF1KB8 SISKISEHVVLTSVTTVLP
.:::.::.:::::..: ::
XP_016 NISKLSEQVVLTSIST-LPAANGAGPLQNWCLQQGPPSSLPSTWLDV
420 430 440 450 460
>>NP_071429 (OMIM: 607448) neuropeptide FF receptor 1 [H (430 aa)
initn: 707 init1: 396 opt: 500 Z-score: 538.8 bits: 108.8 E(85289): 2.8e-23
Smith-Waterman score: 650; 33.9% identity (60.3% similar) in 401 aa overlap (2-398:4-357)
10 20 30 40 50
pF1KB8 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFV
::: :... . .. . . . : . : : : . . ..:.::. .:.
NP_071 MEGEPSQPPNSSWPLSQNGTN-TEATPATNLTFSSY----YQHTSPVAAMFIVAYALIFL
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 VALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHAL
. .:::::::. : .:.::.::::.::.::...:.:: .:.:..:. .. .: : .:
NP_071 LCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 CKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVP
::. .:..:::..:.:: ::..:. : ::. : : :.: .: :::..: :: :
NP_071 CKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB8 QAAVM----ECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMA
.:... : . . ::. . : : : . . ..: . .: :::::.:...
NP_071 SAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVM
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB8 YFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARR
: .: ::: : :: :. : : . .::: : :
NP_071 YARIARKL--CQAPG-----------PAP--GGEEAA-----DPRAS---------RRRA
240 250 260
300 310 320 330 340 350
pF1KB8 KTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAAN
....::..: : :.: .::. .: .: .:.. . . .. : :.:::.. ::.::
NP_071 RVVHMLVMVALFFTLSWLPLWALLLLID-YGQLSAPQLHLVTVYAFPFAHWLAFFNSSAN
270 280 290 300 310 320
360 370 380 390 400 410
pF1KB8 PIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEH
::::.... .::. :.::: : : :: :.:::
NP_071 PIIYGYFNENFRRGFQAAFRARL-----C-------PRPSGSHKEAYSERPGGLLHRRVF
330 340 350 360 370
420
pF1KB8 VVLTSVTTVLP
NP_071 VVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI
380 390 400 410 420 430
>>NP_444264 (OMIM: 607449) neuropeptide FF receptor 2 is (420 aa)
initn: 638 init1: 402 opt: 490 Z-score: 528.3 bits: 106.8 E(85289): 1.1e-22
Smith-Waterman score: 618; 33.2% identity (60.3% similar) in 355 aa overlap (27-373:27-348)
10 20 30 40 50 60
pF1KB8 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
: : . :. ::. : ..: .: .: .
NP_444 MNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYV-NYYLHQPQVAAIFIISYFLIFFLC
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
..:::.::. : ::.::.:::: ::.::...:.:: .:.: .:: .: .: ::...::
NP_444 MMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
. .:..::...:.:: ::.::. . .:. : : . : :. ::.....:: :.:
NP_444 ISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSA
120 130 140 150 160 170
190 200 210 220 230
pF1KB8 AVMECSSVLPELANRTRLFSV--------CDERWADDLYPKIYHSCFFIVTYLAPLGLMA
.... : : :.:: : : : : .. . ::: . .: :::::.:..
NP_444 VMLH---VQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIV
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB8 MAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRA
. : .: .:. .: : ..:. : :
NP_444 IMYGRIGISLFRAAVPHTGRKNQEQWHVVS----------------------------RK
240 250 260
300 310 320 330 340 350
pF1KB8 RRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSA
..: :::..: :.: : .::. .: .:. . . . .: . :.:::...::.
NP_444 KQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYI-YPFAHWLAFGNSS
270 280 290 300 310 320
360 370 380 390 400 410
pF1KB8 ANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKIS
.:::::.:.. .::. :. ::
NP_444 VNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQN
330 340 350 360 370 380
>>NP_001138228 (OMIM: 607449) neuropeptide FF receptor 2 (423 aa)
initn: 638 init1: 402 opt: 490 Z-score: 528.2 bits: 106.8 E(85289): 1.1e-22
Smith-Waterman score: 618; 33.2% identity (60.3% similar) in 355 aa overlap (27-373:30-351)
10 20 30 40 50
pF1KB8 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVF
: : . :. ::. : ..: .: .:
NP_001 MFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYV-NYYLHQPQVAAIFIISYFLIF
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 VVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHA
. ..:::.::. : ::.::.:::: ::.::...:.:: .:.: .:: .: .: ::..
NP_001 FLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 LCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMV
.::. .:..::...:.:: ::.::. . .:. : : . : :. ::.....::
NP_001 MCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMS
120 130 140 150 160 170
180 190 200 210 220
pF1KB8 PQAAVMECSSVLPELANRTRLFSV--------CDERWADDLYPKIYHSCFFIVTYLAPLG
:.:.... : : :.:: : : : : .. . ::: . .: :::::.
NP_001 PSAVMLH---VQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLS
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB8 LMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQ
:... : .: .:. .: : ..:. :
NP_001 LIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVS---------------------------
240 250 260
290 300 310 320 330 340
pF1KB8 MRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYA
: ..: :::..: :.: : .::. .: .:. . . . .: . :.:::...
NP_001 -RKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYI-YPFAHWLAFG
270 280 290 300 310 320
350 360 370 380 390 400
pF1KB8 NSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSIS
::..:::::.:.. .::. :. ::
NP_001 NSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQEST
330 340 350 360 370 380
>>NP_004876 (OMIM: 607449) neuropeptide FF receptor 2 is (522 aa)
initn: 583 init1: 402 opt: 490 Z-score: 527.1 bits: 106.9 E(85289): 1.3e-22
Smith-Waterman score: 618; 33.2% identity (60.3% similar) in 355 aa overlap (27-373:129-450)
10 20 30 40 50
pF1KB8 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAV
: : . :. ::. : ..: .: .
NP_004 ERFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYV-NYYLHQPQVAAIFIISYFLI
100 110 120 130 140 150
60 70 80 90 100 110
pF1KB8 FVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGH
: . ..:::.::. : ::.::.:::: ::.::...:.:: .:.: .:: .: .: ::.
NP_004 FFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGN
160 170 180 190 200 210
120 130 140 150 160 170
pF1KB8 ALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIM
..::. .:..::...:.:: ::.::. . .:. : : . : :. ::.....::
NP_004 TMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIM
220 230 240 250 260 270
180 190 200 210 220
pF1KB8 VPQAAVMECSSVLPELANRTRLFSV--------CDERWADDLYPKIYHSCFFIVTYLAPL
:.:.... : : :.:: : : : : .. . ::: . .: :::::
NP_004 SPSAVMLH---VQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPL
280 290 300 310 320 330
230 240 250 260 270 280
pF1KB8 GLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVK
.:... : .: .:. .: : ..:. :
NP_004 SLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVS--------------------------
340 350 360
290 300 310 320 330 340
pF1KB8 QMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVY
: ..: :::..: :.: : .::. .: .:. . . . .: . :.:::..
NP_004 --RKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYI-YPFAHWLAF
370 380 390 400 410 420
350 360 370 380 390 400
pF1KB8 ANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSI
.::..:::::.:.. .::. :. ::
NP_004 GNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQES
430 440 450 460 470 480
425 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 10:17:47 2016 done: Fri Nov 4 10:17:49 2016
Total Scan time: 7.340 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]