Result of FASTA (omim) for
pFN21AB5566
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5566, 264 aa
1>>>pF1KB5566 264 - 264 aa - 264 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3804+/-0.000356; mu= 14.4556+/- 0.022
mean_var=63.2239+/-12.621, 0's: 0 Z-trim(114.0): 17 B-trim: 17 in 1/51
Lambda= 0.161300
statistics sampled from 23533 (23550) to 23533 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.276), width: 16
Scan time: 6.850
The best scores are: opt bits E(85289)
NP_002787 (OMIM: 602177) proteasome subunit beta t ( 264) 1755 416.8 2e-116
NP_004150 (OMIM: 177046,256040) proteasome subunit ( 272) 213 58.0 2.1e-08
NP_683720 (OMIM: 177046,256040) proteasome subunit ( 276) 213 58.0 2.1e-08
NP_002784 (OMIM: 602017) proteasome subunit beta t ( 241) 190 52.6 7.8e-07
NP_002785 (OMIM: 602175) proteasome subunit beta t ( 201) 186 51.7 1.3e-06
NP_002788 (OMIM: 600306) proteasome subunit beta t ( 263) 187 51.9 1.4e-06
NP_001186708 (OMIM: 602175) proteasome subunit bet ( 176) 169 47.7 1.8e-05
NP_002790 (OMIM: 604030) proteasome subunit beta t ( 277) 160 45.7 0.00011
NP_002789 (OMIM: 600307) proteasome subunit beta t ( 239) 143 41.7 0.0015
NP_002791 (OMIM: 177045) proteasome subunit beta t ( 219) 138 40.5 0.0031
NP_001093250 (OMIM: 611137) proteasome subunit bet ( 300) 139 40.8 0.0035
>>NP_002787 (OMIM: 602177) proteasome subunit beta type- (264 aa)
initn: 1755 init1: 1755 opt: 1755 Z-score: 2211.3 bits: 416.8 E(85289): 2e-116
Smith-Waterman score: 1755; 100.0% identity (100.0% similar) in 264 aa overlap (1-264:1-264)
10 20 30 40 50 60
pF1KB5 MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 SLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEK
190 200 210 220 230 240
250 260
pF1KB5 GVEIEGPLSTETNWDIAHMISGFE
::::::::::::::::::::::::
NP_002 GVEIEGPLSTETNWDIAHMISGFE
250 260
>>NP_004150 (OMIM: 177046,256040) proteasome subunit bet (272 aa)
initn: 189 init1: 128 opt: 213 Z-score: 271.8 bits: 58.0 E(85289): 2.1e-08
Smith-Waterman score: 213; 28.6% identity (53.5% similar) in 213 aa overlap (47-258:62-265)
20 30 40 50 60 70
pF1KB5 APGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYG
: :. ::..:. ::. ::. :.: .: :
NP_004 TLPTPVSSGCPGLEPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAG
40 50 60 70 80 90
80 90 100 110 120 130
pF1KB5 SLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSW
: .......: . :: :: :: ...:.. : .:. : : .
NP_004 SYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKEC-RLYYLRNGERISVSAASKL
100 110 120 130 140 150
140 150 160 170 180 190
pF1KB5 LTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLR
:. : . :. :. ..:. : : . : ::: :. . ..:: : : ..
NP_004 LSNMMCQYRG-MGLSMGSMICGWDKKGPG-LYYVDEHGTRLSGNMFSTGSGNTYAYGVMD
160 170 180 190 200
200 210 220 230 240 250
pF1KB5 EVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEKG-VEIEGPLSTETNWD
.: :: :: :: .: . .::. : . .. . : : :..: ::... :
NP_004 SGY--RPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVE---STDVS-D
210 220 230 240 250 260
260
pF1KB5 IAHMISGFE
. :
NP_004 LLHQYREANQ
270
>>NP_683720 (OMIM: 177046,256040) proteasome subunit bet (276 aa)
initn: 189 init1: 128 opt: 213 Z-score: 271.7 bits: 58.0 E(85289): 2.1e-08
Smith-Waterman score: 213; 28.6% identity (53.5% similar) in 213 aa overlap (47-258:66-269)
20 30 40 50 60 70
pF1KB5 APGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYG
: :. ::..:. ::. ::. :.: .: :
NP_683 SMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAG
40 50 60 70 80 90
80 90 100 110 120 130
pF1KB5 SLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSW
: .......: . :: :: :: ...:.. : .:. : : .
NP_683 SYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKEC-RLYYLRNGERISVSAASKL
100 110 120 130 140 150
140 150 160 170 180 190
pF1KB5 LTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLR
:. : . :. :. ..:. : : . : ::: :. . ..:: : : ..
NP_683 LSNMMCQYRG-MGLSMGSMICGWDKKGPG-LYYVDEHGTRLSGNMFSTGSGNTYAYGVMD
160 170 180 190 200 210
200 210 220 230 240 250
pF1KB5 EVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEKG-VEIEGPLSTETNWD
.: :: :: :: .: . .::. : . .. . : : :..: ::... :
NP_683 SGY--RPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVE---STDVS-D
220 230 240 250 260
260
pF1KB5 IAHMISGFE
. :
NP_683 LLHQYREANQ
270
>>NP_002784 (OMIM: 602017) proteasome subunit beta type- (241 aa)
initn: 100 init1: 48 opt: 190 Z-score: 243.7 bits: 52.6 E(85289): 7.8e-07
Smith-Waterman score: 190; 25.5% identity (55.7% similar) in 235 aa overlap (22-245:8-234)
10 20 30 40 50
pF1KB5 MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMV-TGTSVLGV
: :. : :.: : ::. .:.: .: ..:..
NP_002 MLSSTAMYSAPGR-DLGMEPHRAA--GPLQLRFSPYVFNGGTILAI
10 20 30 40
60 70 80 90 100 110
pF1KB5 KFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDE
: ...:.: : : . :. . ......:..: :: ..: : ... . .
NP_002 AGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKII-EARLKM
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB5 ELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGY-ADGESFLGYVDMLGVAYE
....... :: . :. .:::: . : . .::: .:.. . : .: .:.
NP_002 YKHSNNKAMTTGAIAAMLSTILYSRR--FFPYYVYNIIGGLDEEGKGAVYSFDPVG-SYQ
110 120 130 140 150
180 190 200 210 220
pF1KB5 APSL-ATGYGAYLAQPLLR--------EVLEKQPVLSQTEARDLVERCMRVLYYRDARSY
:. : : .. . :::: . .:. : :: .: ::. . ::. .
NP_002 RDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVP-LSLDRAMRLVKDVFISAAERDVYTG
160 170 180 190 200 210
230 240 250 260
pF1KB5 NRFQIATVTEKGVEIEGPLSTETNWDIAHMISGFE
. ..: ::..:.. :
NP_002 DALRICIVTKEGIREETVSLRKD
220 230 240
>>NP_002785 (OMIM: 602175) proteasome subunit beta type- (201 aa)
initn: 89 init1: 55 opt: 186 Z-score: 239.9 bits: 51.7 E(85289): 1.3e-06
Smith-Waterman score: 186; 21.2% identity (59.3% similar) in 189 aa overlap (56-242:4-188)
30 40 50 60 70 80
pF1KB5 STPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNIS
..:.. :..:.: ... . . . .
NP_002 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHD
10 20 30
90 100 110 120 130 140
pF1KB5 RIMRVNNSTMLGASGDYAD-FQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSR
........ .: :. .: :. . . : .. . .:. :: : .. : . .
NP_002 KMFKMSEKILLLCVGEAGDTVQFAEYI--QKNVQLYKMRNGYELSPTAAANFTRRNLADC
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB5 RSKMNPLWNTMVIGGYADGES-FLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQP
. .: .....:: . :. : :.:.:.. .:: : ::::.:. .: . :
NP_002 LRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYT--P
100 110 120 130 140
210 220 230 240 250 260
pF1KB5 VLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSTETNWDIAHMISGF
..:. .: .:...:.. : : . :.. . ..:.
NP_002 TISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
150 160 170 180 190 200
pF1KB5 E
>>NP_002788 (OMIM: 600306) proteasome subunit beta type- (263 aa)
initn: 169 init1: 117 opt: 187 Z-score: 239.3 bits: 51.9 E(85289): 1.4e-06
Smith-Waterman score: 188; 25.3% identity (54.0% similar) in 237 aa overlap (5-241:21-242)
10 20 30 40
pF1KB5 MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPIT
::.:. : :: :.. : :. :. .. . :
NP_002 MALASVLERPLPVNQRGFFGLGGRADLLDLGP--GSL----SDGLSLAAPGWGVPEEPGI
10 20 30 40 50
50 60 70 80 90 100
pF1KB5 RTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYAD
. :. ::..:. ::. ::..::: .. :. .........: . .: ::
NP_002 E----MLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAAD
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB5 FQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGE
.. ...:... :: . . : : . :. .:. .. :. .::. : :
NP_002 CSFWERLLARQCRIYELR-NKERISVAAASKLLANMVYQYKG-MGLSMGTMICGWDKRGP
120 130 140 150 160
170 180 190 200 210 220
pF1KB5 SFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYR
. : ::: : . ....: :. : .. . . : .: ::..: . ::
NP_002 G-LYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYD--LEVEQAYDLARRAIYQATYR
170 180 190 200 210 220
230 240 250 260
pF1KB5 DARSYNRFQIATVTEKGVEIEGPLSTETNWDIAHMISGFE
:: : . .. : : :
NP_002 DAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
230 240 250 260
>>NP_001186708 (OMIM: 602175) proteasome subunit beta ty (176 aa)
initn: 89 init1: 55 opt: 169 Z-score: 219.4 bits: 47.7 E(85289): 1.8e-05
Smith-Waterman score: 169; 22.6% identity (59.1% similar) in 159 aa overlap (86-242:9-163)
60 70 80 90 100 110
pF1KB5 VLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYAD-FQYLKQVLGQ
........ .: :. .: :. . . :
NP_001 MEYLIDHDKMFKMSEKILLLCVGEAGDTVQFAEYI--Q
10 20 30
120 130 140 150 160 170
pF1KB5 MVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGES-FLGYVDML
.. . .:. :: : .. : . . . .: .....:: . :. : :.:.:
NP_001 KNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYL
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB5 GVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQ
.. .:: : ::::.:. .: . :..:. .: .:...:.. : : . :.
NP_001 AALAKAPFAAHGYGAFLTLSILDRYYT--PTISRERAVELLRKCLEELQKRFILNLPTFS
100 110 120 130 140 150
240 250 260
pF1KB5 IATVTEKGVEIEGPLSTETNWDIAHMISGFE
. . ..:.
NP_001 VRIIDKNGIHDLDNISFPKQGS
160 170
>>NP_002790 (OMIM: 604030) proteasome subunit beta type- (277 aa)
initn: 130 init1: 104 opt: 160 Z-score: 205.0 bits: 45.7 E(85289): 0.00011
Smith-Waterman score: 160; 20.6% identity (56.0% similar) in 218 aa overlap (33-249:28-233)
10 20 30 40 50 60
pF1KB5 AFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFE
: :. :. : .: :::.. :: ..
NP_002 MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRK-----TGTTIAGVVYK
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 GGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELL
:.:..:: .. : .. .: :.: .. . . ..: :: .. :.... . ::
NP_002 DGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNL---ELH
60 70 80 90 100
130 140 150 160 170 180
pF1KB5 GDGHSYSPRAIHS-WLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPS
. . . ::.. . . . : : . . . ..:.:: : . : . . :
NP_002 SLSTGRLPRVVTANRMLKQMLFRYQGY--IGAALVLGGVDVTGPHLYSIYPHGSTDKLPY
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB5 LATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEKG
.. : :. :. .... . .: . . ::..:: . . . . : : . ... .....
NP_002 VTMGSGSLAAMAVFEDKF--RPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNK
170 180 190 200 210 220
250 260
pF1KB5 VEIEGPLSTETNWDIAHMISGFE
... : .
NP_002 LDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
230 240 250 260 270
>>NP_002789 (OMIM: 600307) proteasome subunit beta type- (239 aa)
initn: 169 init1: 114 opt: 143 Z-score: 184.6 bits: 41.7 E(85289): 0.0015
Smith-Waterman score: 143; 23.5% identity (52.6% similar) in 196 aa overlap (52-243:33-219)
30 40 50 60 70 80
pF1KB5 YRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARF
:::....:.:.::::..:: . ::
NP_002 ATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIAN
10 20 30 40 50 60
90 100 110 120 130
pF1KB5 RNISRIMRVNNSTMLGASGDYADFQYLKQ-VLGQMVIDEELLGDGHSYSPRAIHSW--LT
: ... ... . ::. :: : . . : :. . :.. : .:. :
NP_002 RVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNE-----PPLVHTAASLF
70 80 90 100 110
140 150 160 170 180 190
pF1KB5 RAMYSRRSKMNPLWNTMVIGGYADGESFLGY-VDMLGVAYEAPSLATGYGAYLAQPLLRE
. : : . : ..:.:. :. : : : :. . : :. .
NP_002 KEMCYRYRE--DLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDA
120 130 140 150 160 170
200 210 220 230 240 250
pF1KB5 VLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSTETNWDIA
. .. ... : ... . . . ::. : . ...:...:.:::
NP_002 TYREG--MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAV
180 190 200 210 220 230
260
pF1KB5 HMISGFE
NP_002 ATLPPA
>>NP_002791 (OMIM: 177045) proteasome subunit beta type- (219 aa)
initn: 127 init1: 100 opt: 138 Z-score: 178.9 bits: 40.5 E(85289): 0.0031
Smith-Waterman score: 138; 21.9% identity (53.6% similar) in 192 aa overlap (52-243:19-204)
30 40 50 60 70 80
pF1KB5 YRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARF
:::....:.:.::::...: : : .
NP_002 MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVN
10 20 30 40
90 100 110 120 130 140
pF1KB5 RNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAM
: .... ... . . ::. :: : . .. . .. :: : : .. . .
NP_002 RVFDKLSPLHERIYCALSGSAADAQAVADMAAYQL---ELHGIELEEPPLVLAAANVVRN
50 60 70 80 90 100
150 160 170 180 190 200
pF1KB5 YSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEK
: . . . : ....:. . :. : . :. . : : :. . . .
NP_002 ISYKYRED-LSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAY--
110 120 130 140 150 160
210 220 230 240 250 260
pF1KB5 QPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSTETNWDIAHMIS
.: .: : : .. . . . ::. : . . ..:.: ::.
NP_002 KPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
170 180 190 200 210
pF1KB5 GFE
264 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 03:53:59 2016 done: Fri Nov 4 03:54:00 2016
Total Scan time: 6.850 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]