Result of FASTA (omim) for
pFN21AB5523
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5523, 2472 aa
1>>>pF1KB5523 2472 - 2472 aa - 2472 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.0113+/-0.000947; mu= -10.9419+/- 0.058
mean_var=571.4565+/-116.518, 0's: 0 Z-trim(109.9): 372 B-trim: 0 in 0/54
Lambda= 0.053652
statistics sampled from 17844 (18192) to 17844 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.493), E-opt: 0.2 (0.213), width: 16
Scan time: 24.100
The best scores are: opt bits E(85289)
NP_003118 (OMIM: 182810,613477) spectrin alpha cha (2472) 16018 1258.4 0
XP_006717312 (OMIM: 182810,613477) PREDICTED: spec (2484) 16018 1258.4 0
NP_001123910 (OMIM: 182810,613477) spectrin alpha (2477) 15998 1256.9 0
XP_006717311 (OMIM: 182810,613477) PREDICTED: spec (2489) 15998 1256.9 0
XP_016870548 (OMIM: 182810,613477) PREDICTED: spec (2471) 15937 1252.2 0
XP_006717313 (OMIM: 182810,613477) PREDICTED: spec (2483) 15937 1252.2 0
XP_006717309 (OMIM: 182810,613477) PREDICTED: spec (2505) 14437 1136.1 0
XP_006717317 (OMIM: 182810,613477) PREDICTED: spec (2498) 14424 1135.0 0
XP_006717308 (OMIM: 182810,613477) PREDICTED: spec (2510) 14424 1135.0 0
NP_001182461 (OMIM: 182810,613477) spectrin alpha (2452) 9241 733.9 6.3e-210
XP_006717316 (OMIM: 182810,613477) PREDICTED: spec (2464) 9241 733.9 6.3e-210
XP_006717314 (OMIM: 182810,613477) PREDICTED: spec (2478) 8231 655.7 2.2e-186
XP_006717310 (OMIM: 182810,613477) PREDICTED: spec (2490) 8231 655.7 2.2e-186
XP_016870550 (OMIM: 182810,613477) PREDICTED: spec (2457) 6802 545.1 4.3e-153
XP_016870549 (OMIM: 182810,613477) PREDICTED: spec (2463) 6802 545.1 4.3e-153
XP_006717315 (OMIM: 182810,613477) PREDICTED: spec (2469) 6802 545.1 4.3e-153
XP_011508221 (OMIM: 130600,182860,266140,270970) P (1695) 4031 330.4 1.2e-88
XP_011508220 (OMIM: 130600,182860,266140,270970) P (2041) 4031 330.5 1.4e-88
XP_011508219 (OMIM: 130600,182860,266140,270970) P (2413) 4031 330.6 1.6e-88
NP_003117 (OMIM: 130600,182860,266140,270970) spec (2419) 4031 330.6 1.6e-88
XP_011508218 (OMIM: 130600,182860,266140,270970) P (2419) 4031 330.6 1.6e-88
NP_842565 (OMIM: 182790) spectrin beta chain, non- (2155) 1889 164.7 1.2e-38
XP_005264575 (OMIM: 182790) PREDICTED: spectrin be (2351) 1889 164.8 1.2e-38
XP_006712150 (OMIM: 182790) PREDICTED: spectrin be (2364) 1889 164.8 1.2e-38
XP_016860270 (OMIM: 182790) PREDICTED: spectrin be (2364) 1889 164.8 1.2e-38
XP_016860268 (OMIM: 182790) PREDICTED: spectrin be (2364) 1889 164.8 1.2e-38
XP_005264574 (OMIM: 182790) PREDICTED: spectrin be (2364) 1889 164.8 1.2e-38
XP_016860269 (OMIM: 182790) PREDICTED: spectrin be (2364) 1889 164.8 1.2e-38
NP_003119 (OMIM: 182790) spectrin beta chain, non- (2364) 1889 164.8 1.2e-38
NP_057726 (OMIM: 605916) spectrin beta chain, non- (3674) 1781 156.6 5.6e-36
XP_016877789 (OMIM: 605916) PREDICTED: spectrin be (3694) 1781 156.6 5.6e-36
XP_016877791 (OMIM: 605916) PREDICTED: spectrin be (2793) 1774 155.9 6.7e-36
XP_016877790 (OMIM: 605916) PREDICTED: spectrin be (3442) 1774 156.0 7.7e-36
XP_016877788 (OMIM: 605916) PREDICTED: spectrin be (3734) 1774 156.1 8.2e-36
XP_006718734 (OMIM: 600224,604985,615386) PREDICTE (2390) 1733 152.7 5.4e-35
XP_016873667 (OMIM: 600224,604985,615386) PREDICTE (2390) 1733 152.7 5.4e-35
XP_016873664 (OMIM: 600224,604985,615386) PREDICTE (2390) 1733 152.7 5.4e-35
XP_016873665 (OMIM: 600224,604985,615386) PREDICTE (2390) 1733 152.7 5.4e-35
XP_016873666 (OMIM: 600224,604985,615386) PREDICTE (2390) 1733 152.7 5.4e-35
XP_005274250 (OMIM: 600224,604985,615386) PREDICTE (2390) 1733 152.7 5.4e-35
XP_016873663 (OMIM: 600224,604985,615386) PREDICTE (2390) 1733 152.7 5.4e-35
XP_005274249 (OMIM: 600224,604985,615386) PREDICTE (2390) 1733 152.7 5.4e-35
XP_006718732 (OMIM: 600224,604985,615386) PREDICTE (2397) 1733 152.7 5.4e-35
NP_008877 (OMIM: 600224,604985,615386) spectrin be (2390) 1729 152.4 6.7e-35
XP_016882540 (OMIM: 606214) PREDICTED: spectrin be (2129) 1344 122.5 5.8e-26
XP_011525475 (OMIM: 606214) PREDICTED: spectrin be (2351) 1344 122.6 6.2e-26
XP_016882539 (OMIM: 606214) PREDICTED: spectrin be (2450) 1344 122.6 6.4e-26
NP_066022 (OMIM: 606214) spectrin beta chain, non- (2564) 1344 122.6 6.6e-26
XP_016882538 (OMIM: 606214) PREDICTED: spectrin be (2564) 1344 122.6 6.6e-26
XP_011535407 (OMIM: 182870,616649) PREDICTED: spec (1554) 1287 118.0 9.9e-25
>>NP_003118 (OMIM: 182810,613477) spectrin alpha chain, (2472 aa)
initn: 16018 init1: 16018 opt: 16018 Z-score: 6724.7 bits: 1258.4 E(85289): 0
Smith-Waterman score: 16018; 100.0% identity (100.0% similar) in 2472 aa overlap (1-2472:1-2472)
10 20 30 40 50 60
pF1KB5 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB5 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB5 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB5 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB5 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB5 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB5 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB5 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB5 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB5 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB5 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB5 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB5 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB5 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KB5 DEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERG
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KB5 ACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEAL
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KB5 LASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRD
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KB5 TINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KB5 NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KB5 ARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KB5 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KB5 FNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALK
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KB5 DQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKA
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KB5 SAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSF
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KB5 RVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KB5 IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDN
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KB5 KYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKS
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KB5 GRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRET
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KB5 ENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAF
2410 2420 2430 2440 2450 2460
2470
pF1KB5 DYVEFTRSLFVN
::::::::::::
NP_003 DYVEFTRSLFVN
2470
>>XP_006717312 (OMIM: 182810,613477) PREDICTED: spectrin (2484 aa)
initn: 16018 init1: 16018 opt: 16018 Z-score: 6724.7 bits: 1258.4 E(85289): 0
Smith-Waterman score: 16018; 100.0% identity (100.0% similar) in 2472 aa overlap (1-2472:13-2484)
10 20 30 40
pF1KB5 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLSSFRKRRVQKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 FQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNL
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 MISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 EAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 KQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB5 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB5 LQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB5 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB5 VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB5 VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB5 DLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEA
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB5 LKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQA
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB5 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB5 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB5 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB5 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB5 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB5 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB5 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB5 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB5 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB5 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB5 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB5 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB5 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRG
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KB5 VIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIK
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KB5 DFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSS
1690 1700 1710 1720 1730 1740
1730 1740 1750 1760 1770 1780
pF1KB5 AFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVG
1750 1760 1770 1780 1790 1800
1790 1800 1810 1820 1830 1840
pF1KB5 SEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQF
1810 1820 1830 1840 1850 1860
1850 1860 1870 1880 1890 1900
pF1KB5 VEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGL
1870 1880 1890 1900 1910 1920
1910 1920 1930 1940 1950 1960
pF1KB5 LKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQR
1930 1940 1950 1960 1970 1980
1970 1980 1990 2000 2010 2020
pF1KB5 KAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAF
1990 2000 2010 2020 2030 2040
2030 2040 2050 2060 2070 2080
pF1KB5 QQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRK
2050 2060 2070 2080 2090 2100
2090 2100 2110 2120 2130 2140
pF1KB5 VEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFN
2110 2120 2130 2140 2150 2160
2150 2160 2170 2180 2190 2200
pF1KB5 QLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQ
2170 2180 2190 2200 2210 2220
2210 2220 2230 2240 2250 2260
pF1KB5 EFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDL
2230 2240 2250 2260 2270 2280
2270 2280 2290 2300 2310 2320
pF1KB5 GAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEF
2290 2300 2310 2320 2330 2340
2330 2340 2350 2360 2370 2380
pF1KB5 SMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSL
2350 2360 2370 2380 2390 2400
2390 2400 2410 2420 2430 2440
pF1KB5 QEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPY
2410 2420 2430 2440 2450 2460
2450 2460 2470
pF1KB5 VDGKGRELPTAFDYVEFTRSLFVN
::::::::::::::::::::::::
XP_006 VDGKGRELPTAFDYVEFTRSLFVN
2470 2480
>>NP_001123910 (OMIM: 182810,613477) spectrin alpha chai (2477 aa)
initn: 10272 init1: 10272 opt: 15998 Z-score: 6716.4 bits: 1256.9 E(85289): 0
Smith-Waterman score: 15998; 99.8% identity (99.8% similar) in 2477 aa overlap (1-2472:1-2477)
10 20 30 40 50 60
pF1KB5 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB5 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB5 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB5 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB5 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB5 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB5 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB5 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB5 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB5 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB5 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB5 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB5 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB5 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610
pF1KB5 DEIEAWISEKLQTASDESYKDPTNIQ-----SKHQKHQAFEAELHANADRIRGVIDMGNS
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 DEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNS
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KB5 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KB5 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KB5 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KB5 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL
1810 1820 1830 1840 1850 1860
1860 1870 1880 1890 1900 1910
pF1KB5 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF
1870 1880 1890 1900 1910 1920
1920 1930 1940 1950 1960 1970
pF1KB5 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN
1930 1940 1950 1960 1970 1980
1980 1990 2000 2010 2020 2030
pF1KB5 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN
1990 2000 2010 2020 2030 2040
2040 2050 2060 2070 2080 2090
pF1KB5 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT
2050 2060 2070 2080 2090 2100
2100 2110 2120 2130 2140 2150
pF1KB5 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR
2110 2120 2130 2140 2150 2160
2160 2170 2180 2190 2200 2210
pF1KB5 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN
2170 2180 2190 2200 2210 2220
2220 2230 2240 2250 2260 2270
pF1KB5 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA
2230 2240 2250 2260 2270 2280
2280 2290 2300 2310 2320 2330
pF1KB5 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF
2290 2300 2310 2320 2330 2340
2340 2350 2360 2370 2380 2390
pF1KB5 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM
2350 2360 2370 2380 2390 2400
2400 2410 2420 2430 2440 2450
pF1KB5 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE
2410 2420 2430 2440 2450 2460
2460 2470
pF1KB5 LPTAFDYVEFTRSLFVN
:::::::::::::::::
NP_001 LPTAFDYVEFTRSLFVN
2470
>>XP_006717311 (OMIM: 182810,613477) PREDICTED: spectrin (2489 aa)
initn: 10272 init1: 10272 opt: 15998 Z-score: 6716.3 bits: 1256.9 E(85289): 0
Smith-Waterman score: 15998; 99.8% identity (99.8% similar) in 2477 aa overlap (1-2472:13-2489)
10 20 30 40
pF1KB5 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLSSFRKRRVQKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 FQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNL
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 MISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 EAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 KQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB5 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB5 LQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB5 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB5 VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB5 VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB5 DLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEA
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB5 LKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQA
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB5 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB5 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB5 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB5 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB5 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB5 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB5 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB5 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB5 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB5 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB5 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB5 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB5 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQ-----SKHQKHQAFEAELHANA
:::::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_006 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KB5 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KB5 NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADS
1690 1700 1710 1720 1730 1740
1730 1740 1750 1760 1770 1780
pF1KB5 LMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEK
1750 1760 1770 1780 1790 1800
1790 1800 1810 1820 1830 1840
pF1KB5 KLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQ
1810 1820 1830 1840 1850 1860
1850 1860 1870 1880 1890 1900
pF1KB5 RLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLA
1870 1880 1890 1900 1910 1920
1910 1920 1930 1940 1950 1960
pF1KB5 AIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEK
1930 1940 1950 1960 1970 1980
1970 1980 1990 2000 2010 2020
pF1KB5 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA
1990 2000 2010 2020 2030 2040
2030 2040 2050 2060 2070 2080
pF1KB5 GLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQ
2050 2060 2070 2080 2090 2100
2090 2100 2110 2120 2130 2140
pF1KB5 SHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA
2110 2120 2130 2140 2150 2160
2150 2160 2170 2180 2190 2200
pF1KB5 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEEN
2170 2180 2190 2200 2210 2220
2210 2220 2230 2240 2250 2260
pF1KB5 DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLK
2230 2240 2250 2260 2270 2280
2270 2280 2290 2300 2310 2320
pF1KB5 KIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEE
2290 2300 2310 2320 2330 2340
2330 2340 2350 2360 2370 2380
pF1KB5 ALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRD
2350 2360 2370 2380 2390 2400
2390 2400 2410 2420 2430 2440
pF1KB5 GHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVS
2410 2420 2430 2440 2450 2460
2450 2460 2470
pF1KB5 HMKPYVDGKGRELPTAFDYVEFTRSLFVN
:::::::::::::::::::::::::::::
XP_006 HMKPYVDGKGRELPTAFDYVEFTRSLFVN
2470 2480
>>XP_016870548 (OMIM: 182810,613477) PREDICTED: spectrin (2471 aa)
initn: 14394 init1: 10272 opt: 15937 Z-score: 6690.9 bits: 1252.2 E(85289): 0
Smith-Waterman score: 15937; 99.6% identity (99.6% similar) in 2477 aa overlap (1-2472:1-2471)
10 20 30 40 50 60
pF1KB5 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB5 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB5 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB5 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB5 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB5 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB5 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB5 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB5 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB5 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB5 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB5 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB5 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB5 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610
pF1KB5 DEIEAWISEKLQTASDESYKDPTNIQ-----SKHQKHQAFEAELHANADRIRGVIDMGNS
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_016 DEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNS
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KB5 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KB5 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KB5 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KB5 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL
1810 1820 1830 1840 1850 1860
1860 1870 1880 1890 1900 1910
pF1KB5 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF
1870 1880 1890 1900 1910 1920
1920 1930 1940 1950 1960 1970
pF1KB5 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN
1930 1940 1950 1960 1970 1980
1980 1990 2000 2010 2020 2030
pF1KB5 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN
1990 2000 2010 2020 2030 2040
2040 2050 2060 2070 2080 2090
pF1KB5 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT
2050 2060 2070 2080 2090 2100
2100 2110 2120 2130 2140 2150
pF1KB5 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR
2110 2120 2130 2140 2150 2160
2160 2170 2180 2190 2200 2210
pF1KB5 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN
2170 2180 2190 2200 2210 2220
2220 2230 2240 2250 2260 2270
pF1KB5 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA
:::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFHQWIQETR------SCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA
2230 2240 2250 2260 2270
2280 2290 2300 2310 2320 2330
pF1KB5 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF
2280 2290 2300 2310 2320 2330
2340 2350 2360 2370 2380 2390
pF1KB5 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM
2340 2350 2360 2370 2380 2390
2400 2410 2420 2430 2440 2450
pF1KB5 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE
2400 2410 2420 2430 2440 2450
2460 2470
pF1KB5 LPTAFDYVEFTRSLFVN
:::::::::::::::::
XP_016 LPTAFDYVEFTRSLFVN
2460 2470
>>XP_006717313 (OMIM: 182810,613477) PREDICTED: spectrin (2483 aa)
initn: 14394 init1: 10272 opt: 15937 Z-score: 6690.8 bits: 1252.2 E(85289): 0
Smith-Waterman score: 15937; 99.6% identity (99.6% similar) in 2477 aa overlap (1-2472:13-2483)
10 20 30 40
pF1KB5 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLSSFRKRRVQKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 FQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNL
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 MISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 EAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 KQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB5 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB5 LQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB5 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB5 VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB5 VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB5 DLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEA
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB5 LKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQA
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB5 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB5 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB5 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB5 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB5 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB5 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB5 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB5 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB5 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB5 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB5 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB5 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB5 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQ-----SKHQKHQAFEAELHANA
:::::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_006 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KB5 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KB5 NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADS
1690 1700 1710 1720 1730 1740
1730 1740 1750 1760 1770 1780
pF1KB5 LMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEK
1750 1760 1770 1780 1790 1800
1790 1800 1810 1820 1830 1840
pF1KB5 KLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQ
1810 1820 1830 1840 1850 1860
1850 1860 1870 1880 1890 1900
pF1KB5 RLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLA
1870 1880 1890 1900 1910 1920
1910 1920 1930 1940 1950 1960
pF1KB5 AIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEK
1930 1940 1950 1960 1970 1980
1970 1980 1990 2000 2010 2020
pF1KB5 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA
1990 2000 2010 2020 2030 2040
2030 2040 2050 2060 2070 2080
pF1KB5 GLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQ
2050 2060 2070 2080 2090 2100
2090 2100 2110 2120 2130 2140
pF1KB5 SHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA
2110 2120 2130 2140 2150 2160
2150 2160 2170 2180 2190 2200
pF1KB5 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEEN
2170 2180 2190 2200 2210 2220
2210 2220 2230 2240 2250 2260
pF1KB5 DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLK
:::::::::::::::::::::: ::::::::::::::::::::::::::::::::
XP_006 DKLRQEFAQHANAFHQWIQETR------SCMVEESGTLESQLEATKRKHQEIRAMRSQLK
2230 2240 2250 2260 2270
2270 2280 2290 2300 2310 2320
pF1KB5 KIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEE
2280 2290 2300 2310 2320 2330
2330 2340 2350 2360 2370 2380
pF1KB5 ALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRD
2340 2350 2360 2370 2380 2390
2390 2400 2410 2420 2430 2440
pF1KB5 GHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVS
2400 2410 2420 2430 2440 2450
2450 2460 2470
pF1KB5 HMKPYVDGKGRELPTAFDYVEFTRSLFVN
:::::::::::::::::::::::::::::
XP_006 HMKPYVDGKGRELPTAFDYVEFTRSLFVN
2460 2470 2480
>>XP_006717309 (OMIM: 182810,613477) PREDICTED: spectrin (2505 aa)
initn: 16004 init1: 14437 opt: 14437 Z-score: 6063.3 bits: 1136.1 E(85289): 0
Smith-Waterman score: 15966; 99.2% identity (99.2% similar) in 2493 aa overlap (1-2472:13-2505)
10 20 30 40
pF1KB5 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLSSFRKRRVQKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 FQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNL
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 MISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 EAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 KQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB5 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB5 LQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB5 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB5 VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB5 VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB5 DLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEA
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB5 LKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQA
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB5 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB5 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB5 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB5 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB5 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB5 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB5 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB5 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB5 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB5 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB5 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB5 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB5 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRG
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KB5 VIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIK
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KB5 DFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSS
1690 1700 1710 1720 1730 1740
1730 1740 1750 1760 1770 1780
pF1KB5 AFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVG
1750 1760 1770 1780 1790 1800
1790 1800 1810 1820 1830 1840
pF1KB5 SEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQF
1810 1820 1830 1840 1850 1860
1850 1860 1870 1880 1890 1900
pF1KB5 VEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGL
1870 1880 1890 1900 1910 1920
1910 1920 1930 1940 1950 1960
pF1KB5 LKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQR
1930 1940 1950 1960 1970 1980
1970 1980 1990 2000 2010 2020
pF1KB5 KAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAF
1990 2000 2010 2020 2030 2040
2030 2040 2050 2060 2070 2080
pF1KB5 QQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRK
2050 2060 2070 2080 2090 2100
2090 2100 2110 2120 2130 2140
pF1KB5 VEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFN
2110 2120 2130 2140 2150 2160
2150 2160 2170 2180 2190 2200
pF1KB5 QLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQ
2170 2180 2190 2200 2210 2220
2210 2220 2230 2240
pF1KB5 EFAQHANAFHQWIQETRTYLLDG---------------------SCMVEESGTLESQLEA
::::::::::::::::::::::: ::::::::::::::::
XP_006 EFAQHANAFHQWIQETRTYLLDGIAYRRVIRVYQYEVGDDLSGRSCMVEESGTLESQLEA
2230 2240 2250 2260 2270 2280
2250 2260 2270 2280 2290 2300
pF1KB5 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHN
2290 2300 2310 2320 2330 2340
2310 2320 2330 2340 2350 2360
pF1KB5 LEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEP
2350 2360 2370 2380 2390 2400
2370 2380 2390 2400 2410 2420
pF1KB5 DPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKE
2410 2420 2430 2440 2450 2460
2430 2440 2450 2460 2470
pF1KB5 ELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN
:::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN
2470 2480 2490 2500
>>XP_006717317 (OMIM: 182810,613477) PREDICTED: spectrin (2498 aa)
initn: 11839 init1: 10272 opt: 14424 Z-score: 6057.9 bits: 1135.0 E(85289): 0
Smith-Waterman score: 15946; 99.0% identity (99.0% similar) in 2498 aa overlap (1-2472:1-2498)
10 20 30 40 50 60
pF1KB5 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB5 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB5 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB5 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB5 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB5 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB5 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB5 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB5 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB5 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB5 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB5 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB5 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB5 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610
pF1KB5 DEIEAWISEKLQTASDESYKDPTNIQ-----SKHQKHQAFEAELHANADRIRGVIDMGNS
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_006 DEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNS
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KB5 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KB5 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KB5 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KB5 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL
1810 1820 1830 1840 1850 1860
1860 1870 1880 1890 1900 1910
pF1KB5 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF
1870 1880 1890 1900 1910 1920
1920 1930 1940 1950 1960 1970
pF1KB5 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN
1930 1940 1950 1960 1970 1980
1980 1990 2000 2010 2020 2030
pF1KB5 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN
1990 2000 2010 2020 2030 2040
2040 2050 2060 2070 2080 2090
pF1KB5 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT
2050 2060 2070 2080 2090 2100
2100 2110 2120 2130 2140 2150
pF1KB5 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR
2110 2120 2130 2140 2150 2160
2160 2170 2180 2190 2200 2210
pF1KB5 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN
2170 2180 2190 2200 2210 2220
2220 2230 2240 2250
pF1KB5 AFHQWIQETRTYLLDG---------------------SCMVEESGTLESQLEATKRKHQE
:::::::::::::::: :::::::::::::::::::::::
XP_006 AFHQWIQETRTYLLDGIAYRRVIRVYQYEVGDDLSGRSCMVEESGTLESQLEATKRKHQE
2230 2240 2250 2260 2270 2280
2260 2270 2280 2290 2300 2310
pF1KB5 IRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQA
2290 2300 2310 2320 2330 2340
2320 2330 2340 2350 2360 2370
pF1KB5 RNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAI
2350 2360 2370 2380 2390 2400
2380 2390 2400 2410 2420 2430
pF1KB5 LDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLT
2410 2420 2430 2440 2450 2460
2440 2450 2460 2470
pF1KB5 REQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN
::::::::::::::::::::::::::::::::::::::
XP_006 REQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN
2470 2480 2490
>>XP_006717308 (OMIM: 182810,613477) PREDICTED: spectrin (2510 aa)
initn: 11839 init1: 10272 opt: 14424 Z-score: 6057.9 bits: 1135.0 E(85289): 0
Smith-Waterman score: 15946; 99.0% identity (99.0% similar) in 2498 aa overlap (1-2472:13-2510)
10 20 30 40
pF1KB5 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLSSFRKRRVQKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 FQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNL
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 MISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 EAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 KQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB5 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB5 LQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB5 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB5 VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB5 VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB5 DLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEA
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB5 LKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQA
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB5 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLED
850 860 870 880 890 900
890 900 910 920 930 940
pF1KB5 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB5 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB5 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB5 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB5 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB5 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB5 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KB5 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KB5 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB5 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB5 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KB5 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQ-----SKHQKHQAFEAELHANA
:::::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_006 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KB5 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KB5 NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADS
1690 1700 1710 1720 1730 1740
1730 1740 1750 1760 1770 1780
pF1KB5 LMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEK
1750 1760 1770 1780 1790 1800
1790 1800 1810 1820 1830 1840
pF1KB5 KLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQ
1810 1820 1830 1840 1850 1860
1850 1860 1870 1880 1890 1900
pF1KB5 RLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLA
1870 1880 1890 1900 1910 1920
1910 1920 1930 1940 1950 1960
pF1KB5 AIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEK
1930 1940 1950 1960 1970 1980
1970 1980 1990 2000 2010 2020
pF1KB5 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA
1990 2000 2010 2020 2030 2040
2030 2040 2050 2060 2070 2080
pF1KB5 GLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQ
2050 2060 2070 2080 2090 2100
2090 2100 2110 2120 2130 2140
pF1KB5 SHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA
2110 2120 2130 2140 2150 2160
2150 2160 2170 2180 2190 2200
pF1KB5 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEEN
2170 2180 2190 2200 2210 2220
2210 2220 2230 2240
pF1KB5 DKLRQEFAQHANAFHQWIQETRTYLLDG---------------------SCMVEESGTLE
:::::::::::::::::::::::::::: :::::::::::
XP_006 DKLRQEFAQHANAFHQWIQETRTYLLDGIAYRRVIRVYQYEVGDDLSGRSCMVEESGTLE
2230 2240 2250 2260 2270 2280
2250 2260 2270 2280 2290 2300
pF1KB5 SQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGM
2290 2300 2310 2320 2330 2340
2310 2320 2330 2340 2350 2360
pF1KB5 RMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMV
2350 2360 2370 2380 2390 2400
2370 2380 2390 2400 2410 2420
pF1KB5 EEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKP
2410 2420 2430 2440 2450 2460
2430 2440 2450 2460 2470
pF1KB5 YVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN
2470 2480 2490 2500 2510
>>NP_001182461 (OMIM: 182810,613477) spectrin alpha chai (2452 aa)
initn: 9155 init1: 9155 opt: 9241 Z-score: 3889.8 bits: 733.9 E(85289): 6.3e-210
Smith-Waterman score: 15852; 99.2% identity (99.2% similar) in 2472 aa overlap (1-2472:1-2452)
10 20 30 40 50 60
pF1KB5 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB5 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB5 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB5 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB5 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB5 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
:::::::::::::::::::::::::::::::: ::::::::
NP_001 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQ--------------------YHSLLELG
1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KB5 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KB5 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KB5 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KB5 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KB5 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KB5 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
1370 1380 1390 1400 1410 1420
1450 1460 1470 1480 1490 1500
pF1KB5 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
1430 1440 1450 1460 1470 1480
1510 1520 1530 1540 1550 1560
pF1KB5 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
1490 1500 1510 1520 1530 1540
1570 1580 1590 1600 1610 1620
pF1KB5 DEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERG
1550 1560 1570 1580 1590 1600
1630 1640 1650 1660 1670 1680
pF1KB5 ACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEAL
1610 1620 1630 1640 1650 1660
1690 1700 1710 1720 1730 1740
pF1KB5 LASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRD
1670 1680 1690 1700 1710 1720
1750 1760 1770 1780 1790 1800
pF1KB5 TINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ
1730 1740 1750 1760 1770 1780
1810 1820 1830 1840 1850 1860
pF1KB5 NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA
1790 1800 1810 1820 1830 1840
1870 1880 1890 1900 1910 1920
pF1KB5 ARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT
1850 1860 1870 1880 1890 1900
1930 1940 1950 1960 1970 1980
pF1KB5 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ
1910 1920 1930 1940 1950 1960
1990 2000 2010 2020 2030 2040
pF1KB5 FNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALK
1970 1980 1990 2000 2010 2020
2050 2060 2070 2080 2090 2100
pF1KB5 DQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKA
2030 2040 2050 2060 2070 2080
2110 2120 2130 2140 2150 2160
pF1KB5 SAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSF
2090 2100 2110 2120 2130 2140
2170 2180 2190 2200 2210 2220
pF1KB5 RVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW
2150 2160 2170 2180 2190 2200
2230 2240 2250 2260 2270 2280
pF1KB5 IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDN
2210 2220 2230 2240 2250 2260
2290 2300 2310 2320 2330 2340
pF1KB5 KYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKS
2270 2280 2290 2300 2310 2320
2350 2360 2370 2380 2390 2400
pF1KB5 GRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRET
2330 2340 2350 2360 2370 2380
2410 2420 2430 2440 2450 2460
pF1KB5 ENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAF
2390 2400 2410 2420 2430 2440
2470
pF1KB5 DYVEFTRSLFVN
::::::::::::
NP_001 DYVEFTRSLFVN
2450
2472 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 03:51:30 2016 done: Fri Nov 4 03:51:34 2016
Total Scan time: 24.100 Total Display time: 2.250
Function used was FASTA [36.3.4 Apr, 2011]