Result of FASTA (ccds) for
pFN21AB4489
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4489, 467 aa
1>>>pF1KB4489 467 - 467 aa - 467 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.8538+/-0.000974; mu= -2.5690+/- 0.059
mean_var=222.2871+/-45.233, 0's: 0 Z-trim(113.1): 19 B-trim: 2 in 1/51
Lambda= 0.086024
statistics sampled from 13787 (13801) to 13787 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.424), width: 16
Scan time: 2.870
The best scores are: opt bits E(32554)
CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13 ( 467) 3298 421.9 7e-118
CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4 ( 465) 2642 340.5 2.2e-93
CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5 ( 465) 2584 333.3 3.3e-91
CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13 ( 430) 1599 211.0 1.9e-54
CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18 ( 467) 1320 176.4 5.5e-44
CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15 ( 320) 1153 155.6 6.9e-38
CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15 ( 381) 1153 155.7 8e-38
CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15 ( 425) 1153 155.7 8.8e-38
CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15 ( 230) 1113 150.6 1.6e-36
CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18 ( 552) 493 73.8 5e-13
>>CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13 (467 aa)
initn: 3298 init1: 3298 opt: 3298 Z-score: 2229.8 bits: 421.9 E(32554): 7e-118
Smith-Waterman score: 3298; 100.0% identity (100.0% similar) in 467 aa overlap (1-467:1-467)
10 20 30 40 50 60
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 FQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 FQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 SGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 SGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 FTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 FTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 NCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 NCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVK
370 380 390 400 410 420
430 440 450 460
pF1KB4 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
430 440 450 460
>>CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4 (465 aa)
initn: 2637 init1: 1354 opt: 2642 Z-score: 1789.9 bits: 340.5 E(32554): 2.2e-93
Smith-Waterman score: 2642; 81.5% identity (90.8% similar) in 465 aa overlap (7-467:3-465)
10 20 30 40 50 60
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
..:::::::::::::::::::::::::::::::.::::::::::::.:::.:::
CCDS37 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS
10 20 30 40 50
70 80 90 100 110 120
pF1KB4 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 CPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB4 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
:::::::::::.:::.::::::::::::::::: ::::.::. . ..:: :: :::.:::
CCDS37 QKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG-QNEPHMPLNATFPDS
120 130 140 150 160 170
190 200 210 220 230
pF1KB4 FQQPPCSALPPSPSHAFSQSPCTAS--YPHSPGSPSEPESPYQHSVDTPPLPYHATEASE
:::: .: ::. .. .:: ..: ::::: : :.: ::.: .:::: : :
CCDS37 FQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTS-SDPGSPFQMPADTPPPAYLPPEDPM
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB4 TQSG-QPVDATADRHVVLS-IPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSV
::.: ::.:.. . : : :: . : ::::.::::..::::::::::.:.::: ::
CCDS37 TQDGSQPMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSV
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB4 LIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIF
:.:::::::::.:::::::::::::::::::::::::::::::::::::::::.::::::
CCDS37 LVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIF
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB4 VQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRM
::::::::.:::::.::::::::::::.:::: :::::::::.::::.::::::::::::
CCDS37 VQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRM
360 370 380 390 400 410
420 430 440 450 460
pF1KB4 SFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
:::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 SFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
420 430 440 450 460
>>CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5 (465 aa)
initn: 2563 init1: 1333 opt: 2584 Z-score: 1751.0 bits: 333.3 E(32554): 3.3e-91
Smith-Waterman score: 2584; 78.8% identity (91.0% similar) in 466 aa overlap (5-467:2-465)
10 20 30 40 50 60
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
: ..:::::::::::::::::::::::::::::::.::::::::::::.:::.:::
CCDS75 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS
10 20 30 40 50
70 80 90 100 110 120
pF1KB4 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
:::::::::::::::::::::::::::::::::::::::::::::::::. ::::::::
CCDS75 SPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB4 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
:::::::::::.:::.:::::::::::.:.::: :::..::. : :.:: ::.:::.:::
CCDS75 QKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLS-HNEPHMPQNATFPDS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB4 FQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQ
:.:: . .: ::. . :: ...::.::.: : : ::.: .:::: : . . :
CCDS75 FHQPNNTPFPLSPNSPYPPSPASSTYPNSPAS-SGPGSPFQLPADTPPPAYMPPDDQMGQ
180 190 200 210 220 230
250 260 270 280 290
pF1KB4 -SGQPVDATADR--HVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVL
..::.:.. . ... :: . : .:: ::::.::::..::::::::::.:.::: :::
CCDS75 DNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB4 IDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFV
.:::::::::..::::::::::::::::::::::::::::::::::::::::.:::::::
CCDS75 VDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFV
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB4 QSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMS
::::::..:::::.:::::::.::::.:::: :::::::::.::::.:::::::::::::
CCDS75 QSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMS
360 370 380 390 400 410
420 430 440 450 460
pF1KB4 FVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
:::::::::::::::::::::::::::::::::::::::::: :::::::
CCDS75 FVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
420 430 440 450 460
>>CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13 (430 aa)
initn: 1593 init1: 1593 opt: 1599 Z-score: 1090.8 bits: 211.0 E(32554): 1.9e-54
Smith-Waterman score: 2966; 92.1% identity (92.1% similar) in 467 aa overlap (1-467:1-430)
10 20 30 40 50 60
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 FQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQ
:::::::::::::::::::::::::::::::::::::::::::
CCDS93 FQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHS-----------------
190 200 210 220
250 260 270 280 290 300
pF1KB4 SGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDG
::::::::::::::::::::::::::::::::::::::::
CCDS93 --------------------DFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDG
230 240 250 260
310 320 330 340 350 360
pF1KB4 FTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 FTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSR
270 280 290 300 310 320
370 380 390 400 410 420
pF1KB4 NCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 NCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVK
330 340 350 360 370 380
430 440 450 460
pF1KB4 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
390 400 410 420 430
>>CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18 (467 aa)
initn: 1759 init1: 894 opt: 1320 Z-score: 903.1 bits: 176.4 E(32554): 5.5e-44
Smith-Waterman score: 1754; 56.7% identity (72.0% similar) in 504 aa overlap (7-467:1-467)
10 20 30 40
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDSLVKKLKK
.::.. :: :.:::::::: :. .:::: :::: ::::::::
CCDS11 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKK
10 20 30 40 50
50 60 70
pF1KB4 KKGAMDELERALSCPGQPSKCVTIP------------------------------RSLDG
: .::::.:.. . .:::::: :::::
CCDS11 T-GRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDG
60 70 80 90 100 110
80 90 100 110 120 130
pF1KB4 RLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETP
:::::::::::::::::.::::::.:::::: .: ::. :. :. :::.:::::.:::::
CCDS11 RLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETP
120 130 140 150 160 170
140 150 160 170 180 190
pF1KB4 VLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAF
::::::::::.: .: : . :: .:.:...: ... : . .: .:
CCDS11 VLPPVLVPRHTEILTELPPLDDYT----HS---IPENTNFPAGIE-PQSNYIPETP----
180 190 200 210 220
200 210 220 230 240 250
pF1KB4 SQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQSGQPVDATADRHVVLSI
: .: : :. . ..:.:: : .: : : . .::. : .
CCDS11 --PP---GYISEDGETSDQQ--LNQSMDTGS-P---AELSPT-TLSPVN-----HSL---
230 240 250 260
260 270 280 290 300 310
pF1KB4 PNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLS
:..:: : :: :::.::::::.::::::.::. :. .::::::::.. ::::::::
CCDS11 ---DLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE-RFCLGLLS
270 280 290 300 310
320 330 340 350 360 370
pF1KB4 NVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIP
:::::.:.: ::::::.::.:::.::::.:::.:::.::::: ::: ..:.:::::::::
CCDS11 NVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIP
320 330 340 350 360 370
380 390 400 410 420 430
pF1KB4 SGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCW
::.::.:::: :: ::::::..:::.::.::.::::::::::::::::.:: :::::::
CCDS11 PGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCW
380 390 400 410 420 430
440 450 460
pF1KB4 IEIHLHGPLQWLDKVLTQMGSPHNPISSVS
::.::.:::::::::::::::: ::.:
CCDS11 IELHLNGPLQWLDKVLTQMGSPSVRCSSMS
440 450 460
>>CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15 (320 aa)
initn: 1115 init1: 898 opt: 1153 Z-score: 793.6 bits: 155.6 E(32554): 6.9e-38
Smith-Waterman score: 1337; 57.9% identity (75.8% similar) in 359 aa overlap (110-467:1-320)
80 90 100 110 120 130
pF1KB4 QVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVL
.: ::: :. :. :::.:::::.:::::::
CCDS53 MELCEFAFNMKKDEVCVNPYHYQRVETPVL
10 20 30
140 150 160 170 180 190
pF1KB4 PPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQ
::::::::.: .. : . :: .:.:...: ... : : .: .:
CCDS53 PPVLVPRHTEIPAEFPPLDDYS----HS---IPENTNFPAGIE--PQSNIPETP------
40 50 60 70
200 210 220 230 240 250
pF1KB4 SPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEA-SETQSGQPVDATADRHVVLSIP
: :: :: .:... :. .: : . : .:.. . .
CCDS53 -P--------PGYLSEDGETSDHQMN------HSMDAGSPNLSPNPMSPAHN--------
80 90 100 110
260 270 280 290 300 310
pF1KB4 NGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSN
: :..:: : :: :::..:::::.::::::.::. :. .::::::::.. :::::::::
CCDS53 NLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSN
120 130 140 150 160 170
320 330 340 350 360 370
pF1KB4 VNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPS
::::...: ::::::.::.:::.::::.:::.:::.::::: ::: ..:.:::::::::
CCDS53 VNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPP
180 190 200 210 220 230
380 390 400 410 420 430
pF1KB4 GCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWI
::.::.:::: :: ::::::..:::.::.::.::::::::::::::::.:: ::::::::
CCDS53 GCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWI
240 250 260 270 280 290
440 450 460
pF1KB4 EIHLHGPLQWLDKVLTQMGSPHNPISSVS
:.::.:::::::::::::::: ::::
CCDS53 ELHLNGPLQWLDKVLTQMGSPSIRCSSVS
300 310 320
>>CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15 (381 aa)
initn: 1371 init1: 898 opt: 1153 Z-score: 792.5 bits: 155.7 E(32554): 8e-38
Smith-Waterman score: 1593; 60.9% identity (77.8% similar) in 396 aa overlap (73-467:25-381)
50 60 70 80 90 100
pF1KB4 KKLKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQ
::::::::::::::::::::::.::::::.
CCDS45 MSCLHPRQTWKGAALVHRKAWWMGRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH
10 20 30 40 50
110 120 130 140 150 160
pF1KB4 SHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRS
:::::. .: ::: :. :. :::.:::::.:::::::::::::::.: .. : .
CCDS45 SHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYS-
60 70 80 90 100 110
170 180 190 200 210 220
pF1KB4 ASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQH
:: .:.:...: ... : : .: .: : :: :: .:
CCDS45 ---HS---IPENTNFPAGIE--PQSNIPETP-------------P--PGYLSEDGETSDH
120 130 140 150
230 240 250 260 270 280
pF1KB4 SVDTPPLPYHATEA-SETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYEL
... :. .: : . : .:.. . . : :..:: : :: :::..::::
CCDS45 QMN------HSMDAGSPNLSPNPMSPAHN--------NLDLQPVTYCEPAFWCSISYYEL
160 170 180 190
290 300 310 320 330 340
pF1KB4 NNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYV
:.::::::.::. :. .::::::::.. :::::::::::::...: ::::::.::.:::.
CCDS45 NQRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYI
200 210 220 230 240 250
350 360 370 380 390 400
pF1KB4 GGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHG
::::.:::.:::.::::: ::: ..:.::::::::: ::.::.:::: :: ::::::..:
CCDS45 GGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQG
260 270 280 290 300 310
410 420 430 440 450 460
pF1KB4 FEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHN
::.::.::.::::::::::::::::.:: :::::::::.::.::::::::::::::::
CCDS45 FEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSI
320 330 340 350 360 370
pF1KB4 PISSVS
::::
CCDS45 RCSSVS
380
>>CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15 (425 aa)
initn: 1559 init1: 898 opt: 1153 Z-score: 791.8 bits: 155.7 E(32554): 8.8e-38
Smith-Waterman score: 1852; 60.6% identity (77.8% similar) in 465 aa overlap (7-467:1-425)
10 20 30 40 50
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWKQGDE---EEKWAEKAVDSLVKKLKKKKGAMDELER
.::.. :: : ::::::::.:.. :::: :::: :::::::: : .::::.
CCDS10 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEK
10 20 30 40 50
60 70 80 90 100 110
pF1KB4 ALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPF
:.. . .::.:::::::::::::::::::::::::.::::::.:::::. .: ::: :
CCDS10 AITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB4 GSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATY
. :. :::.:::::.:::::::::::::::.: .. : . :: .:.:...
CCDS10 NMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYS----HS---IPENTNF
120 130 140 150 160
180 190 200 210 220 230
pF1KB4 PDSFQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEA-
: ... : : .: .: : :: :: .:... :. .:
CCDS10 PAGIE--PQSNIPETP-------------P--PGYLSEDGETSDHQMN------HSMDAG
170 180 190 200
240 250 260 270 280 290
pF1KB4 SETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSV
: . : .:.. . . : :..:: : :: :::..:::::.::::::.::. :.
CCDS10 SPNLSPNPMSPAHN--------NLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSM
210 220 230 240 250
300 310 320 330 340 350
pF1KB4 LIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIF
.::::::::.. :::::::::::::...: ::::::.::.:::.::::.:::.:::.::
CCDS10 TVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIF
260 270 280 290 300 310
360 370 380 390 400 410
pF1KB4 VQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRM
::: ::: ..:.::::::::: ::.::.:::: :: ::::::..:::.::.::.::::::
CCDS10 VQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRM
320 330 340 350 360 370
420 430 440 450 460
pF1KB4 SFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
::::::::::.:: :::::::::.::.:::::::::::::::: ::::
CCDS10 SFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
380 390 400 410 420
>>CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15 (230 aa)
initn: 963 init1: 898 opt: 1113 Z-score: 769.0 bits: 150.6 E(32554): 1.6e-36
Smith-Waterman score: 1113; 75.1% identity (90.9% similar) in 209 aa overlap (259-467:23-230)
230 240 250 260 270 280
pF1KB4 LPYHATEASETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGET
: :..:: : :: :::..:::::.:::::
CCDS53 MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGET
10 20 30 40 50
290 300 310 320 330 340
pF1KB4 FQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAE
:.::. :. .::::::::.. :::::::::::::...: ::::::.::.:::.::::.::
CCDS53 FHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAE
60 70 80 90 100 110
350 360 370 380 390 400
pF1KB4 CVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYEL
:.:::.::::: ::: ..:.::::::::: ::.::.:::: :: ::::::..:::.::.:
CCDS53 CLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQL
120 130 140 150 160 170
410 420 430 440 450 460
pF1KB4 TKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
:.::::::::::::::::.:: :::::::::.::.:::::::::::::::: ::::
CCDS53 TRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
180 190 200 210 220 230
>>CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18 (552 aa)
initn: 741 init1: 231 opt: 493 Z-score: 347.4 bits: 73.8 E(32554): 5e-13
Smith-Waterman score: 794; 36.1% identity (59.5% similar) in 457 aa overlap (3-397:7-451)
10 20 30 40 50
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELE
..:: :. .. :. :. .:: : : .:..:..:::::::.:: .: :
CCDS11 MDNMSITNTPTSNDACLS--IVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLI
10 20 30 40 50
60 70 80 90 100 110
pF1KB4 RALSCPG-QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEF
:.. : .::::::: :.:::::::. :::.::::: :.::::::... ::: .. :..
CCDS11 TAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQY
60 70 80 90 100 110
120 130 140 150 160
pF1KB4 PFGSKQKEVCINPYHYRRVETPVL-----------PPVLVPRHS---EYNPQLSLLAKFR
: : ::.:::::.:: .: . : .. . ... : :: .. .
CCDS11 AFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGH
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB4 SASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASYPHSP-GSPSEPESPY
: . ..: : : . .... : . : :: :.: : ::..:. : .: :.: :
CCDS11 SIQTIQHP--PSNRASTETYSTP--ALLAPSESNATS----TANFPNIPVASTSQPASIL
180 190 200 210 220
230 240 250
pF1KB4 --QHS-----VDTPPLP-------------YHATEASETQSGQPVDATAD----------
.:: . . : : :: . .. ... . : .
CCDS11 GGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQ
230 240 250 260 270 280
260 270 280 290
pF1KB4 RHVVLSIPNGDFRPVCYE-----------EPQHWCSVAYYELNNRVGETFQASSRS--VL
.: . : . :: : :..:::.::.:.. .:::::.. : :
CCDS11 HHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVT
290 300 310 320 330 340
300 310 320 330 340 350
pF1KB4 IDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECVSDSSIF
.::..:::.. .::::: ::::.:. .:: .: ::::::.: : :.:...:.:: ..:
CCDS11 VDGYVDPSGG-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVF
350 360 370 380 390 400
360 370 380 390 400 410
pF1KB4 VQSRNCNYQHGFHPA-TVCKIPSGCSLKVFN-NQLFAQLLAQSVHHGFEVVYELTKMCTI
::: . . : :. .: :: . .:::. : :. :.
CCDS11 VQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGN
410 420 430 440 450 460
420 430 440 450 460
pF1KB4 RMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
CCDS11 IPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIH
470 480 490 500 510 520
467 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 03:01:25 2016 done: Fri Nov 4 03:01:26 2016
Total Scan time: 2.870 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]