Result of FASTA (omim) for
pFN21AB9022
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9022, 1712 aa
1>>>pF1KB9022 1712 - 1712 aa - 1712 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.1788+/-0.00063; mu= -2.8799+/- 0.039
mean_var=656.9879+/-135.972, 0's: 0 Z-trim(121.0): 564 B-trim: 1231 in 1/58
Lambda= 0.050037
statistics sampled from 36248 (36882) to 36248 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.682), E-opt: 0.2 (0.432), width: 16
Scan time: 22.080
The best scores are: opt bits E(85289)
NP_001837 (OMIM: 120090,614483,614519) collagen al (1712) 12760 938.3 0
NP_001274687 (OMIM: 300914,303631) collagen alpha- (1707) 5864 440.5 6.2e-122
XP_006724680 (OMIM: 300914,303631) PREDICTED: coll (1708) 5863 440.4 6.5e-122
XP_011529155 (OMIM: 300914,303631) PREDICTED: coll (1680) 5681 427.3 5.8e-118
NP_378667 (OMIM: 300914,303631) collagen alpha-6(I (1690) 5194 392.1 2.2e-107
NP_001838 (OMIM: 300914,303631) collagen alpha-6(I (1691) 5194 392.1 2.2e-107
NP_001836 (OMIM: 120130,175780,180000,607595,61177 (1669) 4883 369.7 1.3e-100
XP_011519350 (OMIM: 120130,175780,180000,607595,61 (1605) 4820 365.1 2.9e-99
XP_011529154 (OMIM: 300914,303631) PREDICTED: coll (1684) 4779 362.2 2.3e-98
NP_001274688 (OMIM: 300914,303631) collagen alpha- (1666) 4707 357.0 8.5e-97
NP_000083 (OMIM: 120131,203780) collagen alpha-4(I (1690) 4629 351.3 4.2e-95
XP_005246338 (OMIM: 120131,203780) PREDICTED: coll (1690) 4629 351.3 4.2e-95
XP_011508860 (OMIM: 120131,203780) PREDICTED: coll (1654) 4600 349.2 1.8e-94
XP_011508859 (OMIM: 120131,203780) PREDICTED: coll (1663) 4523 343.7 8.5e-93
XP_016858786 (OMIM: 120131,203780) PREDICTED: coll (1651) 4506 342.4 2e-92
NP_001274689 (OMIM: 300914,303631) collagen alpha- (1633) 4446 338.1 3.9e-91
XP_011529156 (OMIM: 300914,303631) PREDICTED: coll (1266) 3840 294.2 5e-78
XP_011508874 (OMIM: 120131,203780) PREDICTED: coll (1132) 3542 272.6 1.4e-71
XP_005246334 (OMIM: 104200,120070,141200,203780) P (1635) 3391 262.0 3.3e-68
NP_000085 (OMIM: 120120,131705,131750,131850,13200 (2944) 3188 247.6 1.2e-63
XP_011531639 (OMIM: 120120,131705,131750,131850,13 (2944) 3188 247.6 1.2e-63
XP_016861177 (OMIM: 120120,131705,131750,131850,13 (2924) 3164 245.9 4.1e-63
XP_016861178 (OMIM: 120120,131705,131750,131850,13 (2609) 3142 244.2 1.1e-62
XP_011508857 (OMIM: 104200,120070,141200,203780) P (1609) 3122 242.5 2.3e-62
NP_000082 (OMIM: 104200,120070,141200,203780) coll (1670) 3122 242.5 2.4e-62
NP_000081 (OMIM: 120180,130020,130050) collagen al (1466) 2870 224.3 6.5e-57
XP_011508875 (OMIM: 120190,130000) PREDICTED: coll (1453) 2855 223.2 1.4e-56
NP_000384 (OMIM: 120190,130000) collagen alpha-2(V (1499) 2855 223.2 1.4e-56
XP_011512601 (OMIM: 120290,184840,215150,277610,60 (1498) 2824 221.0 6.6e-56
NP_542411 (OMIM: 120290,184840,215150,277610,60186 (1736) 2824 221.1 7.2e-56
XP_016865739 (OMIM: 120290,184840,215150,277610,60 (1736) 2824 221.1 7.2e-56
NP_542410 (OMIM: 120290,184840,215150,277610,60186 (1629) 2820 220.7 8.5e-56
XP_011512602 (OMIM: 120290,184840,215150,277610,60 (1438) 2816 220.4 9.6e-56
XP_011512604 (OMIM: 120290,184840,215150,277610,60 (1365) 2813 220.1 1.1e-55
NP_542412 (OMIM: 120290,184840,215150,277610,60186 (1650) 2815 220.4 1.1e-55
NP_542197 (OMIM: 120280,154780,228520,603932,60484 (1690) 2814 220.3 1.2e-55
NP_001177638 (OMIM: 120280,154780,228520,603932,60 (1767) 2814 220.3 1.2e-55
NP_001845 (OMIM: 120280,154780,228520,603932,60484 (1806) 2814 220.4 1.2e-55
NP_542196 (OMIM: 120280,154780,228520,603932,60484 (1818) 2814 220.4 1.2e-55
XP_016855824 (OMIM: 120280,154780,228520,603932,60 (1855) 2814 220.4 1.2e-55
XP_016855823 (OMIM: 120280,154780,228520,603932,60 (1857) 2814 220.4 1.2e-55
XP_016865740 (OMIM: 120290,184840,215150,277610,60 (1342) 2761 216.4 1.4e-54
NP_000079 (OMIM: 114000,120150,130000,130060,16620 (1464) 2750 215.6 2.6e-54
XP_011526344 (OMIM: 120216) PREDICTED: collagen al (1744) 2743 215.2 4.2e-54
NP_056534 (OMIM: 120216) collagen alpha-3(V) chain (1745) 2743 215.2 4.2e-54
NP_149162 (OMIM: 108300,120140,132450,150600,15121 (1418) 2694 211.6 4.3e-53
XP_016874319 (OMIM: 108300,120140,132450,150600,15 (1465) 2694 211.6 4.4e-53
NP_001835 (OMIM: 108300,120140,132450,150600,15121 (1487) 2694 211.6 4.4e-53
XP_016874318 (OMIM: 108300,120140,132450,150600,15 (1534) 2694 211.6 4.5e-53
XP_016874317 (OMIM: 108300,120140,132450,150600,15 (1535) 2694 211.6 4.5e-53
>>NP_001837 (OMIM: 120090,614483,614519) collagen alpha- (1712 aa)
initn: 12760 init1: 12760 opt: 12760 Z-score: 5000.5 bits: 938.3 E(85289): 0
Smith-Waterman score: 12760; 99.9% identity (100.0% similar) in 1712 aa overlap (1-1712:1-1712)
10 20 30 40 50 60
pF1KB9 MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLAGVKKFDVPCGGRDCSGGCQCYPEKGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLAGVKKFDVPCGGRDCSGGCQCYPEKGGR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 GQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYALPKEERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYALPKEERD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 RYRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVKG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 EKGDVGQPGPNGIPSDTLHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGISLKGEEGIMGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKGDVGQPGPNGIPSDTLHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGISLKGEEGIMGF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 PGLRGYPGLSGEKGSPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPPGLPAYSPHPSLAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGLRGYPGLSGEKGSPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPPGLPAYSPHPSLAKG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 ARGDPGFPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGLPGEMGPKGFIGDPGIPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARGDPGFPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGLPGEMGPKGFIGDPGIPAL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 YGGPPGPDGKRGPPGPPGLPGPPGPDGFLFGLKGAKGRAGFPGLPGSPGARGPKGWKGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGGPPGPDGKRGPPGPPGLPGPPGPDGFLFGLKGAKGRAGFPGLPGSPGARGPKGWKGDA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 GECRCTEGDEAIKGLPGLPGPKGFAGINGEPGRKGDKGDPGQHGLPGFPGLKGVPGNIGA
::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
NP_001 GECRCTEGDEAIKGLPGLPGPKGFAGINGEPGRKGDRGDPGQHGLPGFPGLKGVPGNIGA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 PGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDGSPGRDGLDGFPGLPGPPGDGIKGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDGSPGRDGLDGFPGLPGPPGDGIKGPP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 GDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFPGDAGLPGPPGFLGPPGPAGTPGQID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFPGDAGLPGPPGFLGPPGPAGTPGQID
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 CDTDVKRAVGGDRQEAIQPGCIAGPKGLPGLPGPPGPTGAKGLRGIPGFAGADGGPGPRG
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
NP_001 CDTDVKRAVGGDRQEAIQPGCIGGPKGLPGLPGPPGPTGAKGLRGIPGFAGADGGPGPRG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB9 LPGDAGREGFPGPPGFIGPRGSKGAVGLPGPDGSPGPIGLPGPDGPPGERGLPGEVLGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPGDAGREGFPGPPGFIGPRGSKGAVGLPGPDGSPGPIGLPGPDGPPGERGLPGEVLGAQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB9 PGPRGDAGVPGQPGLKGLPGDRGPPGFRGSQGMPGMPGLKGQPGLPGPSGQPGLYGPPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPRGDAGVPGQPGLKGLPGDRGPPGFRGSQGMPGMPGLKGQPGLPGPSGQPGLYGPPGL
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB9 HGFPGAPGQEGPLGLPGIPGREGLPGDRGDPGDTGAPGPVGMKGLSGDRGDAGFTGEQGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGFPGAPGQEGPLGLPGIPGREGLPGDRGDPGDTGAPGPVGMKGLSGDRGDAGFTGEQGH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB9 PGSPGFKGIDGMPGTPGLKGDRGSPGMDGFQGMPGLKGRPGFPGSKGEAGFFGIPGLKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGSPGFKGIDGMPGTPGLKGDRGSPGMDGFQGMPGLKGRPGFPGSKGEAGFFGIPGLKGL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB9 AGEPGFKGSRGDPGPPGPPPVILPGMKDIKGEKGDEGPMGLKGYLGAKGIQGMPGIPGLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGEPGFKGSRGDPGPPGPPPVILPGMKDIKGEKGDEGPMGLKGYLGAKGIQGMPGIPGLS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB9 GIPGLPGRPGHIKGVKGDIGVPGIPGLPGFPGVAGPPGITGFPGFIGSRGDKGAPGRAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIPGLPGRPGHIKGVKGDIGVPGIPGLPGFPGVAGPPGITGFPGFIGSRGDKGAPGRAGL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB9 YGEIGATGDFGDIGDTINLPGRPGLKGERGTTGIPGLKGFFGEKGTEGDIGFPGITGVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGEIGATGDFGDIGDTINLPGRPGLKGERGTTGIPGLKGFFGEKGTEGDIGFPGITGVTG
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB9 VQGPPGLKGQTGFPGLTGPPGSQGELGRIGLPGGKGDDGWPGAPGLPGFPGLRGIRGLHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQGPPGLKGQTGFPGLTGPPGSQGELGRIGLPGGKGDDGWPGAPGLPGFPGLRGIRGLHG
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB9 LPGTKGFPGSPGSDIHGDPGFPGPPGERGDPGEANTLPGPVGVPGQKGDQGAPGERGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPGTKGFPGSPGSDIHGDPGFPGPPGERGDPGEANTLPGPVGVPGQKGDQGAPGERGPPG
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB9 SPGLQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPGLQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPG
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB9 TPGTKGWAGDSGPQGRPGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPGTKGWAGDSGPQGRPGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPG
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB9 APGTVGAPGIAGIPQKIAVQPGTVGPQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGTVGAPGIAGIPQKIAVQPGTVGPQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB9 GRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQ
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB9 EPMCPVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPMCPVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASR
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KB9 NDKSYWLSTTAPLPMMPVAEDEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NDKSYWLSTTAPLPMMPVAEDEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLW
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KB9 IGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIP
1630 1640 1650 1660 1670 1680
1690 1700 1710
pF1KB9 EQSFQGSPSADTLKAGLIRTHISRCQVCMKNL
::::::::::::::::::::::::::::::::
NP_001 EQSFQGSPSADTLKAGLIRTHISRCQVCMKNL
1690 1700 1710
>>NP_001274687 (OMIM: 300914,303631) collagen alpha-6(IV (1707 aa)
initn: 6777 init1: 2681 opt: 5864 Z-score: 2310.1 bits: 440.5 E(85289): 6.2e-122
Smith-Waterman score: 5865; 51.8% identity (65.2% similar) in 1752 aa overlap (11-1712:3-1707)
10 20 30 40 50 60
pF1KB9 MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLAGVKKFDVPCGGRDCSGGCQCYPEKGGR
:.: :::: ::. . . . :: :.. ::::.::::.:::.::::.:
NP_001 MHPGL--WLLL--VTLCLTEELAAAGEKSYGKPCGGQDCSGSCQCFPEKGAR
10 20 30 40
70 80 90 100 110 120
pF1KB9 GQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIP
:.:::.: :: .:: :. : ::.: ::..: : : ::::: : :: :: : .:::
NP_001 GRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIP
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB9 GHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYALPKEERD
::::: :::: :: :::::::: : :: : :. :::: : ::.::.: : .
NP_001 GHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKG
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB9 RYRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVKG
..:.:: ::: :. :: : :: : .::.: :: :::::::: : .:: :::: : ::
NP_001 -MKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKG
170 180 190 200 210 220
250 260 270 280
pF1KB9 EKGDVGQPGPNGIPSDT--LHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGI---------
::::: ::: : : .: :. . : : ::: : .: ::: :
NP_001 VKGDVGLPGPAGPPPSTGELEFMGFPKG----KKGSKGEPGPKGFPGISGPPGFPGLGTT
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 ---SLKGEEGIMGFPGLRGYPGLSGEKGSPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPP
. :::.:: :.:: :: : : .: :::.:..: :. : .: .: .:. :: : :
NP_001 GEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB9 GLPAY-SPHPSLAKGARGDPG---FPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGL
: .. . .. .: :::: .:: .:. : :: : :.:: :.:: :.
NP_001 GPDVFIDIDGAVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALS--------GV
350 360 370 380 390
410 420 430 440 450
pF1KB9 PGEMGPKGFIG---DPGIPALYG-GPPGPDGKRGPPGPPGLPGPPGPDGFLFGLKGAKGR
:: .::.:: : : : :. : : :. : ::::: ::::.:. :.. .
NP_001 PGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKE--
400 410 420 430 440 450
460 470 480 490 500 510
pF1KB9 AGFPGLPGSPGARGP---KGWKGDAGECRCTEGDEAIKGLPGLPGPKGFAGINGEPGRKG
.::::: : : .: :: :::.: : : .: : :: ::: : :. : :: ::
NP_001 SGFPGLRGEQGPKGNLGLKGIKGDSGFCAC-DGGVPNTGPPGEPGPPGPWGLIGLPGLKG
460 470 480 490 500 510
520 530 540 550 560 570
pF1KB9 DKGDPGQHGLPGFPGLKGVPGNIGAPGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDG
.:: :. : : : :. : .: :::: ::. : .: :. : : :..: :
NP_001 ARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVIG
520 530 540 550 560 570
580 590 600 610 620 630
pF1KB9 SPGRDGLDGFPGLPGPPGDGIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFP
::.::. :.::::: :::: .: ::. : ::.:: :: :: : :: ::::: : ::.:
NP_001 EPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGNGLPGLPGPRGLP
580 590 600 610 620 630
640 650 660 670 680
pF1KB9 GDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKRAVG-GD--RQEAIQPGCIA----GPKGL
:: : : :: : :: : :: : :: :: ...: :: ::.:.
NP_001 GDKGKDGLPGQQGLPGSKG-----DC---CCREVGKGDLDTERGITLPCIIPGSYGPSGF
640 650 660 670 680
690 700 710 720 730 740
pF1KB9 PGLPGPPGPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVG-
:: :: ::: :: ::.:: : :. : .: ::. : .: ::: :::: :: :
NP_001 PGTPGFPGP---KGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGF
690 700 710 720 730 740
750 760 770 780 790 800
pF1KB9 --LPGPDGSPGPIGLPGPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPP
::: :: :: :: :: :: .: :...::. : :. :. : : ::. :: : :
NP_001 PGLPGKDGLPGMIGSPGL---PGSKGATGDIFGAENGAPGEQGLQGLTGHKGFLGDSGLP
750 760 770 780 790
810 820 830 840 850 860
pF1KB9 GFRGSQGMPGMPGLKGQPGLPGPSGQPGLYGPPGLHGFPGAPGQEGPLGLPGIPGREGLP
:..: .: ::. : ::. : :: :: : : :: : : :. : : ::.:: : :
NP_001 GLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHP
800 810 820 830 840 850
870 880 890 900 910 920
pF1KB9 GDRGDPGDTGAPGPVGMKGLSGDRGDAGFTGEQGHPGSPGFKGIDGMPGTPGLKGDRGSP
: .: : : :: . ::: : .: : : : :::: :. :.:. : ::..::
NP_001 GKKGTRGKKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSGPKGEKGSV
860 870 880 890 900 910
930 940 950 960 970 980
pF1KB9 GMDGFQGMPGLKGRPGFPGSKGEAGFFGIPGLKGLAGEPGFKGSRGDPGPPGPPPVILPG
:. :: :.::: : :: : :: : : : .: :: :: ::.::.::: : : :
NP_001 GFVGFPGIPGLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRP-
920 930 940 950 960 970
990 1000 1010 1020 1030 1040
pF1KB9 MKDI--KGEKGDEGPMGLKGYLGAKGIQGMPGIPGLSGIPGLPGRPGHIKGVKGDIGVPG
:... ::.::..: : .:. : .: .: : :: :.:: :: :: ::::.: : ::
NP_001 MSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPG
980 990 1000 1010 1020 1030
1050 1060 1070 1080 1090 1100
pF1KB9 IPGLPGFPGVAGPPGITGFPGFIGSRGDKGAPGRAGLYGEIGATGDFGDIGDTINLPGRP
. :. :.::. : :::::::. : :..: : :: : : : :: :.:... : :
NP_001 FMGIRGLPGLKGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSP
1040 1050 1060 1070 1080 1090
1110 1120 1130 1140 1150 1160
pF1KB9 GLKGERGTTGIPGLKGFFGEKGTEGDIGFPGITGVTGVQGPPGLKGQTGFPGLTGPPGSQ
: ::. : .:. : :: . : :.::::: : .: :..:..:.:: : ::
NP_001 GPKGQPGESGFKGTKG---RDGLIGNIGFPGNK---GEDGKVGVSGDVGLPGAPGFPGVA
1100 1110 1120 1130 1140 1150
1170 1180 1190 1200 1210
pF1KB9 GELGRIGLPGGKGDDGW--P-GAPGL--P-GFPGLRGIRGLHGLPGTKGFPGSPGSDIHG
: :. ::::..: .: : :.::: : ::::. :..::.::::::: :.:: .: :
NP_001 GMRGEPGLPGSSGHQGAIGPLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITG
1160 1170 1180 1190 1200 1210
1220 1230 1240 1250 1260 1270
pF1KB9 DPG---FPGPPGERGDPGEANTLPGPVGVPGQKGDQGAPGERGPPGSPGLQGFPGITPPS
:: .::: ::.: :: . :: :. :::::.: :: .:: : :: :::. ::
NP_001 VPGPAGLPGPKGEKGYPGIGIGAPGKPGLRGQKGDRGFPGLQGPAGLPGA---PGISLPS
1220 1230 1240 1250 1260
1280 1290 1300 1310 1320 1330
pF1KB9 NISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQ
:.: ::: : ::. : .: :: :::: . ...::::.:: :: :: :: :: :
NP_001 LIAGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGD---Q
1270 1280 1290 1300 1310 1320
1340 1350 1360 1370 1380 1390
pF1KB9 GRPGVFGLPGE---KGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIA
: :: ::::: :: ::: ::::. : .: :: : : :: : :. : : :: .
NP_001 GIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPGQT
1330 1340 1350 1360 1370 1380
1400 1410 1420 1430 1440 1450
pF1KB9 GIPQKIAVQPGTVGPQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGF
. . : :: .: : : :: :. : ::: : : .: :: : .: .:. . ::
NP_001 PTAEAVQVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGA
1390 1400 1410 1420 1430 1440
1460 1470 1480 1490 1500 1510
pF1KB9 RGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKL
:: : : ::: : :::::. : :.:::::.:. .:: ::::::..: : ::.::..:
NP_001 LGDPGLPGLQGPPGFEGAPGQQGPFGMPGMPGQSMRVGYTLVKHSQSEQVPPCPIGMSQL
1450 1460 1470 1480 1490 1500
1520 1530 1540 1550 1560 1570
pF1KB9 WSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTA
: :::::. ::::::::::::.::::: :::::::.::: ..::.:: ::::::::::::
NP_001 WVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTA
1510 1520 1530 1540 1550 1560
1580 1590 1600 1610 1620 1630
pF1KB9 PLPMMPVAEDEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAA
:.:::::.. .: :::::::::::. ::::::::..::.:: :::::::::::::::::
NP_001 PIPMMPVSQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAA
1570 1580 1590 1600 1610 1620
1640 1650 1660 1670 1680 1690
pF1KB9 GDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPE-QSFQGSPSA
: :::::::::::::::::::::::::.:.::::::.::::::::::. : :.: : .
NP_001 GAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGELPVS
1630 1640 1650 1660 1670 1680
1700 1710
pF1KB9 DTLKAGLIRTHISRCQVCMKNL
.::::: ..:..::::::::.:
NP_001 ETLKAGQLHTRVSRCQVCMKSL
1690 1700
>>XP_006724680 (OMIM: 300914,303631) PREDICTED: collagen (1708 aa)
initn: 6777 init1: 2681 opt: 5863 Z-score: 2309.7 bits: 440.4 E(85289): 6.5e-122
Smith-Waterman score: 5864; 51.8% identity (65.2% similar) in 1747 aa overlap (16-1712:7-1708)
10 20 30 40 50 60
pF1KB9 MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLAGVKKFDVPCGGRDCSGGCQCYPEKGGR
:::: ::. . . . :: :.. ::::.::::.:::.::::.:
XP_006 MLINKLWLLL--VTLCLTEELAAAGEKSYGKPCGGQDCSGSCQCFPEKGAR
10 20 30 40
70 80 90 100 110 120
pF1KB9 GQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIP
:.:::.: :: .:: :. : ::.: ::..: : : ::::: : :: :: : .:::
XP_006 GRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIP
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB9 GHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYALPKEERD
::::: :::: :: :::::::: : :: : :. :::: : ::.::.: : .
XP_006 GHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKG
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB9 RYRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVKG
..:.:: ::: :. :: : :: : .::.: :: :::::::: : .:: :::: : ::
XP_006 -MKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKG
170 180 190 200 210 220
250 260 270 280
pF1KB9 EKGDVGQPGPNGIPSDT--LHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGI---------
::::: ::: : : .: :. . : : ::: : .: ::: :
XP_006 VKGDVGLPGPAGPPPSTGELEFMGFPKG----KKGSKGEPGPKGFPGISGPPGFPGLGTT
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 ---SLKGEEGIMGFPGLRGYPGLSGEKGSPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPP
. :::.:: :.:: :: : : .: :::.:..: :. : .: .: .:. :: : :
XP_006 GEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB9 GLPAY-SPHPSLAKGARGDPG---FPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGL
: .. . .. .: :::: .:: .:. : :: : :.:: :.:: :.
XP_006 GPDVFIDIDGAVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALS--------GV
350 360 370 380 390
410 420 430 440 450
pF1KB9 PGEMGPKGFIG---DPGIPALYG-GPPGPDGKRGPPGPPGLPGPPGPDGFLFGLKGAKGR
:: .::.:: : : : :. : : :. : ::::: ::::.:. :.. .
XP_006 PGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKE--
400 410 420 430 440 450
460 470 480 490 500 510
pF1KB9 AGFPGLPGSPGARGP---KGWKGDAGECRCTEGDEAIKGLPGLPGPKGFAGINGEPGRKG
.::::: : : .: :: :::.: : : .: : :: ::: : :. : :: ::
XP_006 SGFPGLRGEQGPKGNLGLKGIKGDSGFCAC-DGGVPNTGPPGEPGPPGPWGLIGLPGLKG
460 470 480 490 500 510
520 530 540 550 560 570
pF1KB9 DKGDPGQHGLPGFPGLKGVPGNIGAPGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDG
.:: :. : : : :. : .: :::: ::. : .: :. : : :..: :
XP_006 ARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVIG
520 530 540 550 560 570
580 590 600 610 620 630
pF1KB9 SPGRDGLDGFPGLPGPPGDGIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFP
::.::. :.::::: :::: .: ::. : ::.:: :: :: : :: ::::: : ::.:
XP_006 EPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGNGLPGLPGPRGLP
580 590 600 610 620 630
640 650 660 670 680
pF1KB9 GDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKRAVGG---DRQEAIQPGCIA----GPKGL
:: : : :: : :: : :: : :: : ...: :: ::.:.
XP_006 GDKGKDGLPGQQGLPGSKG-----DC---CCREVGKGDLDTERGITLPCIIPGSYGPSGF
640 650 660 670 680
690 700 710 720 730 740
pF1KB9 PGLPGPPGPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVG-
:: :: ::: :: ::.:: : :. : .: ::. : .: ::: :::: :: :
XP_006 PGTPGFPGP---KGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGF
690 700 710 720 730 740
750 760 770 780 790 800
pF1KB9 --LPGPDGSPGPIGLPGPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPP
::: :: :: :: :: :: .: :...::. : :. :. : : ::. :: : :
XP_006 PGLPGKDGLPGMIGSPGL---PGSKGATGDIFGAENGAPGEQGLQGLTGHKGFLGDSGLP
750 760 770 780 790
810 820 830 840 850 860
pF1KB9 GFRGSQGMPGMPGLKGQPGLPGPSGQPGLYGPPGLHGFPGAPGQEGPLGLPGIPGREGLP
:..: .: ::. : ::. : :: :: : : :: : : :. : : ::.:: : :
XP_006 GLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHP
800 810 820 830 840 850
870 880 890 900 910 920
pF1KB9 GDRGDPGDTGAPGPVGMKGLSGDRGDAGFTGEQGHPGSPGFKGIDGMPGTPGLKGDRGSP
: .: : : :: . ::: : .: : : : :::: :. :.:. : ::..::
XP_006 GKKGTRGKKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSGPKGEKGSV
860 870 880 890 900 910
930 940 950 960 970 980
pF1KB9 GMDGFQGMPGLKGRPGFPGSKGEAGFFGIPGLKGLAGEPGFKGSRGDPGPPGPPPVILPG
:. :: :.::: : :: : :: : : : .: :: :: ::.::.::: : : :
XP_006 GFVGFPGIPGLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRP-
920 930 940 950 960 970
990 1000 1010 1020 1030 1040
pF1KB9 MKDI--KGEKGDEGPMGLKGYLGAKGIQGMPGIPGLSGIPGLPGRPGHIKGVKGDIGVPG
:... ::.::..: : .:. : .: .: : :: :.:: :: :: ::::.: : ::
XP_006 MSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPG
980 990 1000 1010 1020 1030
1050 1060 1070 1080 1090 1100
pF1KB9 IPGLPGFPGVAGPPGITGFPGFIGSRGDKGAPGRAGLYGEIGATGDFGDIGDTINLPGRP
. :. :.::. : :::::::. : :..: : :: : : : :: :.:... : :
XP_006 FMGIRGLPGLKGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSP
1040 1050 1060 1070 1080 1090
1110 1120 1130 1140 1150 1160
pF1KB9 GLKGERGTTGIPGLKGFFGEKGTEGDIGFPGITGVTGVQGPPGLKGQTGFPGLTGPPGSQ
: ::. : .:. : : :. : :.::::: : .: :..:..:.:: : ::
XP_006 GPKGQPGESGFKGTK---GRDGLIGNIGFPGNKGE---DGKVGVSGDVGLPGAPGFPGVA
1100 1110 1120 1130 1140 1150
1170 1180 1190 1200 1210
pF1KB9 GELGRIGLPGGKGDDGW--P-GAPGL--P-GFPGLRGIRGLHGLPGTKGFPGSPGSDIHG
: :. ::::..: .: : :.::: : ::::. :..::.::::::: :.:: .: :
XP_006 GMRGEPGLPGSSGHQGAIGPLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITG
1160 1170 1180 1190 1200 1210
1220 1230 1240 1250 1260 1270
pF1KB9 DPG---FPGPPGERGDPGEANTLPGPVGVPGQKGDQGAPGERGPPGSPGLQGFPGITPPS
:: .::: ::.: :: . :: :. :::::.: :: .:: : :: :::. ::
XP_006 VPGPAGLPGPKGEKGYPGIGIGAPGKPGLRGQKGDRGFPGLQGPAGLPGA---PGISLPS
1220 1230 1240 1250 1260
1280 1290 1300 1310 1320 1330
pF1KB9 NISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQ
:.: ::: : ::. : .: :: :::: . ...::::.:: :: :: :: :: :
XP_006 LIAGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGD---Q
1270 1280 1290 1300 1310 1320
1340 1350 1360 1370 1380 1390
pF1KB9 GRPGVFGLPGE---KGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIA
: :: ::::: :: ::: ::::. : .: :: : : :: : :. : : :: .
XP_006 GIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPGQT
1330 1340 1350 1360 1370 1380
1400 1410 1420 1430 1440 1450
pF1KB9 GIPQKIAVQPGTVGPQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGF
. . : :: .: : : :: :. : ::: : : .: :: : .: .:. . ::
XP_006 PTAEAVQVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGA
1390 1400 1410 1420 1430 1440
1460 1470 1480 1490 1500 1510
pF1KB9 RGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKL
:: : : ::: : :::::. : :.:::::.:. .:: ::::::..: : ::.::..:
XP_006 LGDPGLPGLQGPPGFEGAPGQQGPFGMPGMPGQSMRVGYTLVKHSQSEQVPPCPIGMSQL
1450 1460 1470 1480 1490 1500
1520 1530 1540 1550 1560 1570
pF1KB9 WSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTA
: :::::. ::::::::::::.::::: :::::::.::: ..::.:: ::::::::::::
XP_006 WVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTA
1510 1520 1530 1540 1550 1560
1580 1590 1600 1610 1620 1630
pF1KB9 PLPMMPVAEDEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAA
:.:::::.. .: :::::::::::. ::::::::..::.:: :::::::::::::::::
XP_006 PIPMMPVSQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAA
1570 1580 1590 1600 1610 1620
1640 1650 1660 1670 1680 1690
pF1KB9 GDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPE-QSFQGSPSA
: :::::::::::::::::::::::::.:.::::::.::::::::::. : :.: : .
XP_006 GAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGELPVS
1630 1640 1650 1660 1670 1680
1700 1710
pF1KB9 DTLKAGLIRTHISRCQVCMKNL
.::::: ..:..::::::::.:
XP_006 ETLKAGQLHTRVSRCQVCMKSL
1690 1700
>>XP_011529155 (OMIM: 300914,303631) PREDICTED: collagen (1680 aa)
initn: 6600 init1: 2681 opt: 5681 Z-score: 2238.8 bits: 427.3 E(85289): 5.8e-118
Smith-Waterman score: 5682; 51.4% identity (64.7% similar) in 1718 aa overlap (47-1712:6-1680)
20 30 40 50 60 70
pF1KB9 LLLGTVTVGFLAQSVLAGVKKFDVPCGGRDCSGGC--QCYPEKGGRGQPGPVGPQGYNGP
:: : . .. .:.:::.: :: .::
XP_011 MSATRCSDGVLGSANEDELLQGRPGPIGIQGPTGP
10 20 30
80 90 100 110 120 130
pF1KB9 PGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIPGHPGQGGPRGRPGY
:. : ::.: ::..: : : ::::: : :: :: : .:::::::: :::: ::
XP_011 QGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIPGHPGQPGPRGPPGL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB9 DGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYALPKEERDRYRGEPGEPGLVGF
:::::::: : :: : :. :::: : ::.::.: : . ..:.:: ::: :.
XP_011 DGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKG-MKGDPGLPGLDGI
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB9 QGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVKGEKGDVGQPGPNGIP
:: : :: : .::.: :: :::::::: : .:: :::: : :: ::::: ::: : :
XP_011 TGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKGVKGDVGLPGPAGPP
160 170 180 190 200 210
260 270 280 290 300
pF1KB9 SDT--LHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGI------------SLKGEEGIMGF
.: :. . : : ::: : .: ::: : . :::.:: :.
XP_011 PSTGELEFMGFPKG----KKGSKGEPGPKGFPGISGPPGFPGLGTTGEKGEKGEKGIPGL
220 230 240 250 260 270
310 320 330 340 350
pF1KB9 PGLRGYPGLSGEKGSPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPPGLPAY-SPHPSLAK
:: :: : : .: :::.:..: :. : .: .: .:. :: : :: .. . .. .
XP_011 PGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLPGPDVFIDIDGAVIS
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB9 GARGDPG---FPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGLPGEMGPKGFIG---
: :::: .:: .:. : :: : :.:: :.:: :.:: .::.:: :
XP_011 GNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALS--------GVPGALGPQGFPGLKG
340 350 360 370 380
420 430 440 450 460 470
pF1KB9 DPGIPALYG-GPPGPDGKRGPPGPPGLPGPPGPDGFLFGLKGAKGRAGFPGLPGSPGARG
: : :. : : :. : ::::: ::::.:. :.. . .::::: : : .:
XP_011 DQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKE--SGFPGLRGEQGPKG
390 400 410 420 430 440
480 490 500 510 520
pF1KB9 P---KGWKGDAGECRCTEGDEAIKGLPGLPGPKGFAGINGEPGRKGDKGDPGQHGLPGFP
:: :::.: : : .: : :: ::: : :. : :: :: .:: :. : :
XP_011 NLGLKGIKGDSGFCAC-DGGVPNTGPPGEPGPPGPWGLIGLPGLKGARGDRGSGGAQGPA
450 460 470 480 490
530 540 550 560 570 580
pF1KB9 GLKGVPGNIGAPGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDGSPGRDGLDGFPGLP
: :. : .: :::: ::. : .: :. : : :..: : ::.::. :.::::
XP_011 GAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVIGEPGKDGVPGLPGLP
500 510 520 530 540 550
590 600 610 620 630 640
pF1KB9 GPPGDGIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFPGDAGLPGPPGFLGP
: :::: .: ::. : ::.:: :: :: : :: ::::: : ::.::: : : :: :
XP_011 GLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGNGLPGLPGPRGLPGDKGKDGLPGQQGL
560 570 580 590 600 610
650 660 670 680 690 700
pF1KB9 PGPAGTPGQIDCDTDVKRAVGG---DRQEAIQPGCIA----GPKGLPGLPGPPGPTGAKG
:: : :: : :: : ...: :: ::.:.:: :: ::: ::
XP_011 PGSKG-----DC---CCREVGKGDLDTERGITLPCIIPGSYGPSGFPGTPGFPGP---KG
620 630 640 650 660
710 720 730 740 750
pF1KB9 LRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVG---LPGPDGSPGPIG
::.:: : :. : .: ::. : .: ::: :::: :: : ::: :: :: ::
XP_011 SRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGFPGLPGKDGLPGMIG
670 680 690 700 710 720
760 770 780 790 800 810
pF1KB9 LPGPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPPGFRGSQGMPGMPGL
: : :: .: :...::. : :. :. : : ::. :: : ::..: .: ::. :
XP_011 SP---GLPGSKGATGDIFGAENGAPGEQGLQGLTGHKGFLGDSGLPGLKGVHGKPGLLGP
730 740 750 760 770 780
820 830 840 850 860 870
pF1KB9 KGQPGLPGPSGQPGLYGPPGLHGFPGAPGQEGPLGLPGIPGREGLPGDRGDPGDTGAPGP
::. : :: :: : : :: : : :. : : ::.:: : :: .: : : ::
XP_011 KGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHPGKKGTRGKKGPPGS
790 800 810 820 830 840
880 890 900 910 920 930
pF1KB9 VGMKGLSGDRGDAGFTGEQGHPGSPGFKGIDGMPGTPGLKGDRGSPGMDGFQGMPGLKGR
. ::: : .: : : : :::: :. :.:. : ::..:: :. :: :.::: :
XP_011 IVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSGPKGEKGSVGFVGFPGIPGLPGI
850 860 870 880 890 900
940 950 960 970 980 990
pF1KB9 PGFPGSKGEAGFFGIPGLKGLAGEPGFKGSRGDPGPPGPPPVILPGMKDI--KGEKGDEG
:: : :: : : : .: :: :: ::.::.::: : : : :... ::.::..:
XP_011 PGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRP-MSNLWLKGDKGSQG
910 920 930 940 950 960
1000 1010 1020 1030 1040 1050
pF1KB9 PMGLKGYLGAKGIQGMPGIPGLSGIPGLPGRPGHIKGVKGDIGVPGIPGLPGFPGVAGPP
: .:. : .: .: : :: :.:: :: :: ::::.: : ::. :. :.::. :
XP_011 SAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMGIRGLPGLKGSS
970 980 990 1000 1010 1020
1060 1070 1080 1090 1100 1110
pF1KB9 GITGFPGFIGSRGDKGAPGRAGLYGEIGATGDFGDIGDTINLPGRPGLKGERGTTGIPGL
:::::::. : :..: : :: : : : :: :.:... : :: ::. : .:. :
XP_011 GITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPGESGFKGT
1030 1040 1050 1060 1070 1080
1120 1130 1140 1150 1160 1170
pF1KB9 KGFFGEKGTEGDIGFPGITGVTGVQGPPGLKGQTGFPGLTGPPGSQGELGRIGLPGGKGD
:: . : :.::::: : .: :..:..:.:: : :: : :. ::::..:
XP_011 KG---RDGLIGNIGFPGNK---GEDGKVGVSGDVGLPGAPGFPGVAGMRGEPGLPGSSGH
1090 1100 1110 1120 1130
1180 1190 1200 1210 1220
pF1KB9 DGW--P-GAPGL--P-GFPGLRGIRGLHGLPGTKGFPGSPGSDIHGDPG---FPGPPGER
.: : :.::: : ::::. :..::.::::::: :.:: .: : :: .::: ::.
XP_011 QGAIGPLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEK
1140 1150 1160 1170 1180 1190
1230 1240 1250 1260 1270 1280
pF1KB9 GDPGEANTLPGPVGVPGQKGDQGAPGERGPPGSPGLQGFPGITPPSNISGAPGDKGAPGI
: :: . :: :. :::::.: :: .:: : :: :::. :: :.: ::: : ::.
XP_011 GYPGIGIGAPGKPGLRGQKGDRGFPGLQGPAGLPGA---PGISLPSLIAGQPGDPGRPGL
1200 1210 1220 1230 1240 1250
1290 1300 1310 1320 1330 1340
pF1KB9 FGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQGRPGVFGLPGE---
: .: :: :::: . ...::::.:: :: :: :: :: :: :: :::::
XP_011 DGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGD---QGIPGFSGLPGELGL
1260 1270 1280 1290 1300 1310
1350 1360 1370 1380 1390 1400
pF1KB9 KGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVG
:: ::: ::::. : .: :: : : :: : :. : : :: . . . : :: .:
XP_011 KGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPGQTPTAEAVQVPPGPLG
1320 1330 1340 1350 1360 1370
1410 1420 1430 1440 1450 1460
pF1KB9 PQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIG
: : :: :. : ::: : : .: :: : .: .:. . :: :: : : ::: :
XP_011 LPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGALGDPGLPGLQGPPG
1380 1390 1400 1410 1420 1430
1470 1480 1490 1500 1510 1520
pF1KB9 QEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLLYFEGQEK
:::::. : :.:::::.:. .:: ::::::..: : ::.::..:: :::::. :::::
XP_011 FEGAPGQQGPFGMPGMPGQSMRVGYTLVKHSQSEQVPPCPIGMSQLWVGYSLLFVEGQEK
1440 1450 1460 1470 1480 1490
1530 1540 1550 1560 1570 1580
pF1KB9 AHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEDEIKP
:::::::.::::: :::::::.::: ..::.:: :::::::::::::.:::::.. .:
XP_011 AHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVSQTQIPQ
1500 1510 1520 1530 1540 1550
1590 1600 1610 1620 1630 1640
pF1KB9 YISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGS
:::::::::::. ::::::::..::.:: :::::::::::::::::: ::::::::::::
XP_011 YISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGS
1560 1570 1580 1590 1600 1610
1650 1660 1670 1680 1690 1700
pF1KB9 CLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPE-QSFQGSPSADTLKAGLIRTHISR
:::::::::::::.:.::::::.::::::::::. : :.: : ..::::: ..:..::
XP_011 CLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGELPVSETLKAGQLHTRVSR
1620 1630 1640 1650 1660 1670
1710
pF1KB9 CQVCMKNL
::::::.:
XP_011 CQVCMKSL
1680
>>NP_378667 (OMIM: 300914,303631) collagen alpha-6(IV) c (1690 aa)
initn: 5233 init1: 2671 opt: 5194 Z-score: 2048.7 bits: 392.1 E(85289): 2.2e-107
Smith-Waterman score: 5841; 51.7% identity (65.0% similar) in 1745 aa overlap (11-1712:3-1690)
10 20 30 40 50 60
pF1KB9 MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLAGVKKFDVPCGGRDCSGGCQCYPEKGGR
:.: :::: ::. . . . :: :.. ::::.::::.:::.::::.:
NP_378 MHPGL--WLLL--VTLCLTEELAAAGEKSYGKPCGGQDCSGSCQCFPEKGAR
10 20 30 40
70 80 90 100 110 120
pF1KB9 GQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIP
:.:::.: :: .:: :. : ::.: ::..: : : ::::: : :: :: : .:::
NP_378 GRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIP
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB9 GHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYALPKEERD
::::: :::: :: :::::::: : :: : :. :::: : ::.::.: : .
NP_378 GHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKG
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB9 RYRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVKG
..:.:: ::: :. :: : :: : .::.: :: :::::::: : .:: :::: : ::
NP_378 -MKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKG
170 180 190 200 210 220
250 260 270 280
pF1KB9 EKGDVGQPGPNGIPSDT--LHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGI---------
::::: ::: : : .: :. . : : ::: : .: ::: :
NP_378 VKGDVGLPGPAGPPPSTGELEFMGFPKG----KKGSKGEPGPKGFPGISGPPGFPGLGTT
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 ---SLKGEEGIMGFPGLRGYPGLSGEKGSPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPP
. :::.:: :.:: :: : : .: :::.:..: :. : .: .: .:. :: : :
NP_378 GEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB9 GLPAY-SPHPSLAKGARGDPG---FPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGL
: .. . .. .: :::: .:: .:. : :: : :.:: :.:: :.
NP_378 GPDVFIDIDGAVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALS--------GV
350 360 370 380 390
410 420 430 440 450
pF1KB9 PGEMGPKGFIG---DPGIPALYG-GPPGPDGKRGPPGPPGLPGPPGPDGFLFGLKGAKGR
:: .::.:: : : : :. : : :. : ::::: ::::.:. :.. .
NP_378 PGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKE--
400 410 420 430 440 450
460 470 480 490 500 510
pF1KB9 AGFPGLPGSPGARGP---KGWKGDAGECRCTEGDEAIKGLPGLPGPKGFAGINGEPGRKG
.::::: : : .: :: :::.: : : .: : :: ::: : :. : :: ::
NP_378 SGFPGLRGEQGPKGNLGLKGIKGDSGFCAC-DGGVPNTGPPGEPGPPGPWGLIGLPGLKG
460 470 480 490 500 510
520 530 540 550 560 570
pF1KB9 DKGDPGQHGLPGFPGLKGVPGNIGAPGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDG
.:: :. : : : :. : .: :::: ::. : .: :. : : :..: :
NP_378 ARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVIG
520 530 540 550 560 570
580 590 600 610 620 630
pF1KB9 SPGRDGLDGFPGLPGPPGDGIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFP
::.::. :.::::: :::: .: ::. : ::.:: :: :: : :: ::::: : ::.:
NP_378 EPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGNGLPGLPGPRGLP
580 590 600 610 620 630
640 650 660 670 680 690
pF1KB9 GDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKRAVGGDRQEAIQPGCIAGPKGLPGLPGPP
:: : : :: : :: : . : : :: ::.:.:: :: :
NP_378 GDKGKDGLPGQQGLPGSKGI--TLPC---------------IIPGSY-GPSGFPGTPGFP
640 650 660 670
700 710 720 730 740 750
pF1KB9 GPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVG---LPGPD
:: :: ::.:: : :. : .: ::. : .: ::: :::: :: : ::: :
NP_378 GP---KGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGFPGLPGKD
680 690 700 710 720 730
760 770 780 790 800 810
pF1KB9 GSPGPIGLPGPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPPGFRGSQG
: :: :: :: :: .: :...::. : :. :. : : ::. :: : ::..: .:
NP_378 GLPGMIGSPGL---PGSKGATGDIFGAENGAPGEQGLQGLTGHKGFLGDSGLPGLKGVHG
740 750 760 770 780
820 830 840 850 860 870
pF1KB9 MPGMPGLKGQPGLPGPSGQPGLYGPPGLHGFPGAPGQEGPLGLPGIPGREGLPGDRGDPG
::. : ::. : :: :: : : :: : : :. : : ::.:: : :: .: :
NP_378 KPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHPGKKGTRG
790 800 810 820 830 840
880 890 900 910 920 930
pF1KB9 DTGAPGPVGMKGLSGDRGDAGFTGEQGHPGSPGFKGIDGMPGTPGLKGDRGSPGMDGFQG
: :: . ::: : .: : : : :::: :. :.:. : ::..:: :. :: :
NP_378 KKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSGPKGEKGSVGFVGFPG
850 860 870 880 890 900
940 950 960 970 980 990
pF1KB9 MPGLKGRPGFPGSKGEAGFFGIPGLKGLAGEPGFKGSRGDPGPPGPPPVILPGMKDI--K
.::: : :: : :: : : : .: :: :: ::.::.::: : : : :... :
NP_378 IPGLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRP-MSNLWLK
910 920 930 940 950 960
1000 1010 1020 1030 1040 1050
pF1KB9 GEKGDEGPMGLKGYLGAKGIQGMPGIPGLSGIPGLPGRPGHIKGVKGDIGVPGIPGLPGF
:.::..: : .:. : .: .: : :: :.:: :: :: ::::.: : ::. :. :.
NP_378 GDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMGIRGL
970 980 990 1000 1010 1020
1060 1070 1080 1090 1100 1110
pF1KB9 PGVAGPPGITGFPGFIGSRGDKGAPGRAGLYGEIGATGDFGDIGDTINLPGRPGLKGERG
::. : :::::::. : :..: : :: : : : :: :.:... : :: ::. :
NP_378 PGLKGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPG
1030 1040 1050 1060 1070 1080
1120 1130 1140 1150 1160 1170
pF1KB9 TTGIPGLKGFFGEKGTEGDIGFPGITGVTGVQGPPGLKGQTGFPGLTGPPGSQGELGRIG
.:. : :: . : :.::::: : .: :..:..:.:: : :: : :. :
NP_378 ESGFKGTKG---RDGLIGNIGFPGNK---GEDGKVGVSGDVGLPGAPGFPGVAGMRGEPG
1090 1100 1110 1120 1130 1140
1180 1190 1200 1210 1220
pF1KB9 LPGGKGDDGW--P-GAPGL--P-GFPGLRGIRGLHGLPGTKGFPGSPGSDIHGDPG---F
:::..: .: : :.::: : ::::. :..::.::::::: :.:: .: : :: .
NP_378 LPGSSGHQGAIGPLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGL
1150 1160 1170 1180 1190 1200
1230 1240 1250 1260 1270 1280
pF1KB9 PGPPGERGDPGEANTLPGPVGVPGQKGDQGAPGERGPPGSPGLQGFPGITPPSNISGAPG
::: ::.: :: . :: :. :::::.: :: .:: : :: :::. :: :.: ::
NP_378 PGPKGEKGYPGIGIGAPGKPGLRGQKGDRGFPGLQGPAGLPGA---PGISLPSLIAGQPG
1210 1220 1230 1240 1250
1290 1300 1310 1320 1330 1340
pF1KB9 DKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQGRPGVFG
: : ::. : .: :: :::: . ...::::.:: :: :: :: :: :: :: :
NP_378 DPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGD---QGIPGFSG
1260 1270 1280 1290 1300 1310
1350 1360 1370 1380 1390
pF1KB9 LPGE---KGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIA
:::: :: ::: ::::. : .: :: : : :: : :. : : :: . . .
NP_378 LPGELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPGQTPTAEAVQ
1320 1330 1340 1350 1360 1370
1400 1410 1420 1430 1440 1450
pF1KB9 VQPGTVGPQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPI
: :: .: : : :: :. : ::: : : .: :: : .: .:. . :: :: :
NP_378 VPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGALGDPGLP
1380 1390 1400 1410 1420 1430
1460 1470 1480 1490 1500 1510
pF1KB9 GHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLL
: ::: : :::::. : :.:::::.:. .:: ::::::..: : ::.::..:: :::::
NP_378 GLQGPPGFEGAPGQQGPFGMPGMPGQSMRVGYTLVKHSQSEQVPPCPIGMSQLWVGYSLL
1440 1450 1460 1470 1480 1490
1520 1530 1540 1550 1560 1570
pF1KB9 YFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPV
. ::::::::::::.::::: :::::::.::: ..::.:: :::::::::::::.:::::
NP_378 FVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPV
1500 1510 1520 1530 1540 1550
1580 1590 1600 1610 1620 1630
pF1KB9 AEDEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQ
.. .: :::::::::::. ::::::::..::.:: :::::::::::::::::: :::::
NP_378 SQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQ
1560 1570 1580 1590 1600 1610
1640 1650 1660 1670 1680 1690
pF1KB9 SLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPE-QSFQGSPSADTLKAGL
::::::::::::::::::::.:.::::::.::::::::::. : :.: : ..:::::
NP_378 SLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGELPVSETLKAGQ
1620 1630 1640 1650 1660 1670
1700 1710
pF1KB9 IRTHISRCQVCMKNL
..:..::::::::.:
NP_378 LHTRVSRCQVCMKSL
1680 1690
>>NP_001838 (OMIM: 300914,303631) collagen alpha-6(IV) c (1691 aa)
initn: 5233 init1: 2671 opt: 5194 Z-score: 2048.7 bits: 392.1 E(85289): 2.2e-107
Smith-Waterman score: 5840; 51.7% identity (65.1% similar) in 1740 aa overlap (16-1712:7-1691)
10 20 30 40 50 60
pF1KB9 MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLAGVKKFDVPCGGRDCSGGCQCYPEKGGR
:::: ::. . . . :: :.. ::::.::::.:::.::::.:
NP_001 MLINKLWLLL--VTLCLTEELAAAGEKSYGKPCGGQDCSGSCQCFPEKGAR
10 20 30 40
70 80 90 100 110 120
pF1KB9 GQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIP
:.:::.: :: .:: :. : ::.: ::..: : : ::::: : :: :: : .:::
NP_001 GRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIP
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB9 GHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYALPKEERD
::::: :::: :: :::::::: : :: : :. :::: : ::.::.: : .
NP_001 GHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKG
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB9 RYRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVKG
..:.:: ::: :. :: : :: : .::.: :: :::::::: : .:: :::: : ::
NP_001 -MKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKG
170 180 190 200 210 220
250 260 270 280
pF1KB9 EKGDVGQPGPNGIPSDT--LHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGI---------
::::: ::: : : .: :. . : : ::: : .: ::: :
NP_001 VKGDVGLPGPAGPPPSTGELEFMGFPKG----KKGSKGEPGPKGFPGISGPPGFPGLGTT
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 ---SLKGEEGIMGFPGLRGYPGLSGEKGSPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPP
. :::.:: :.:: :: : : .: :::.:..: :. : .: .: .:. :: : :
NP_001 GEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB9 GLPAY-SPHPSLAKGARGDPG---FPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGL
: .. . .. .: :::: .:: .:. : :: : :.:: :.:: :.
NP_001 GPDVFIDIDGAVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALS--------GV
350 360 370 380 390
410 420 430 440 450
pF1KB9 PGEMGPKGFIG---DPGIPALYG-GPPGPDGKRGPPGPPGLPGPPGPDGFLFGLKGAKGR
:: .::.:: : : : :. : : :. : ::::: ::::.:. :.. .
NP_001 PGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKE--
400 410 420 430 440 450
460 470 480 490 500 510
pF1KB9 AGFPGLPGSPGARGP---KGWKGDAGECRCTEGDEAIKGLPGLPGPKGFAGINGEPGRKG
.::::: : : .: :: :::.: : : .: : :: ::: : :. : :: ::
NP_001 SGFPGLRGEQGPKGNLGLKGIKGDSGFCAC-DGGVPNTGPPGEPGPPGPWGLIGLPGLKG
460 470 480 490 500 510
520 530 540 550 560 570
pF1KB9 DKGDPGQHGLPGFPGLKGVPGNIGAPGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDG
.:: :. : : : :. : .: :::: ::. : .: :. : : :..: :
NP_001 ARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVIG
520 530 540 550 560 570
580 590 600 610 620 630
pF1KB9 SPGRDGLDGFPGLPGPPGDGIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFP
::.::. :.::::: :::: .: ::. : ::.:: :: :: : :: ::::: : ::.:
NP_001 EPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGNGLPGLPGPRGLP
580 590 600 610 620 630
640 650 660 670 680 690
pF1KB9 GDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKRAVGGDRQEAIQPGCIAGPKGLPGLPGPP
:: : : :: : :: : . : : :: ::.:.:: :: :
NP_001 GDKGKDGLPGQQGLPGSKGI--TLPC---------------IIPGSY-GPSGFPGTPGFP
640 650 660 670
700 710 720 730 740 750
pF1KB9 GPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVG---LPGPD
:: :: ::.:: : :. : .: ::. : .: ::: :::: :: : ::: :
NP_001 GP---KGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGFPGLPGKD
680 690 700 710 720 730
760 770 780 790 800 810
pF1KB9 GSPGPIGLPGPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPPGFRGSQG
: :: :: :: :: .: :...::. : :. :. : : ::. :: : ::..: .:
NP_001 GLPGMIGSPGL---PGSKGATGDIFGAENGAPGEQGLQGLTGHKGFLGDSGLPGLKGVHG
740 750 760 770 780
820 830 840 850 860 870
pF1KB9 MPGMPGLKGQPGLPGPSGQPGLYGPPGLHGFPGAPGQEGPLGLPGIPGREGLPGDRGDPG
::. : ::. : :: :: : : :: : : :. : : ::.:: : :: .: :
NP_001 KPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHPGKKGTRG
790 800 810 820 830 840
880 890 900 910 920 930
pF1KB9 DTGAPGPVGMKGLSGDRGDAGFTGEQGHPGSPGFKGIDGMPGTPGLKGDRGSPGMDGFQG
: :: . ::: : .: : : : :::: :. :.:. : ::..:: :. :: :
NP_001 KKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSGPKGEKGSVGFVGFPG
850 860 870 880 890 900
940 950 960 970 980 990
pF1KB9 MPGLKGRPGFPGSKGEAGFFGIPGLKGLAGEPGFKGSRGDPGPPGPPPVILPGMKDI--K
.::: : :: : :: : : : .: :: :: ::.::.::: : : : :... :
NP_001 IPGLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRP-MSNLWLK
910 920 930 940 950 960
1000 1010 1020 1030 1040 1050
pF1KB9 GEKGDEGPMGLKGYLGAKGIQGMPGIPGLSGIPGLPGRPGHIKGVKGDIGVPGIPGLPGF
:.::..: : .:. : .: .: : :: :.:: :: :: ::::.: : ::. :. :.
NP_001 GDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMGIRGL
970 980 990 1000 1010 1020
1060 1070 1080 1090 1100 1110
pF1KB9 PGVAGPPGITGFPGFIGSRGDKGAPGRAGLYGEIGATGDFGDIGDTINLPGRPGLKGERG
::. : :::::::. : :..: : :: : : : :: :.:... : :: ::. :
NP_001 PGLKGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPG
1030 1040 1050 1060 1070 1080
1120 1130 1140 1150 1160 1170
pF1KB9 TTGIPGLKGFFGEKGTEGDIGFPGITGVTGVQGPPGLKGQTGFPGLTGPPGSQGELGRIG
.:. : : :. : :.::::: : .: :..:..:.:: : :: : :. :
NP_001 ESGFKGTK---GRDGLIGNIGFPGNKGE---DGKVGVSGDVGLPGAPGFPGVAGMRGEPG
1090 1100 1110 1120 1130 1140
1180 1190 1200 1210 1220
pF1KB9 LPGGKGDDGW--P-GAPGL--P-GFPGLRGIRGLHGLPGTKGFPGSPGSDIHGDPG---F
:::..: .: : :.::: : ::::. :..::.::::::: :.:: .: : :: .
NP_001 LPGSSGHQGAIGPLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGL
1150 1160 1170 1180 1190 1200
1230 1240 1250 1260 1270 1280
pF1KB9 PGPPGERGDPGEANTLPGPVGVPGQKGDQGAPGERGPPGSPGLQGFPGITPPSNISGAPG
::: ::.: :: . :: :. :::::.: :: .:: : :: :::. :: :.: ::
NP_001 PGPKGEKGYPGIGIGAPGKPGLRGQKGDRGFPGLQGPAGLPGA---PGISLPSLIAGQPG
1210 1220 1230 1240 1250
1290 1300 1310 1320 1330 1340
pF1KB9 DKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQGRPGVFG
: : ::. : .: :: :::: . ...::::.:: :: :: :: :: :: :: :
NP_001 DPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGD---QGIPGFSG
1260 1270 1280 1290 1300 1310
1350 1360 1370 1380 1390
pF1KB9 LPGE---KGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIA
:::: :: ::: ::::. : .: :: : : :: : :. : : :: . . .
NP_001 LPGELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPGQTPTAEAVQ
1320 1330 1340 1350 1360 1370
1400 1410 1420 1430 1440 1450
pF1KB9 VQPGTVGPQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPI
: :: .: : : :: :. : ::: : : .: :: : .: .:. . :: :: :
NP_001 VPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGALGDPGLP
1380 1390 1400 1410 1420 1430
1460 1470 1480 1490 1500 1510
pF1KB9 GHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLL
: ::: : :::::. : :.:::::.:. .:: ::::::..: : ::.::..:: :::::
NP_001 GLQGPPGFEGAPGQQGPFGMPGMPGQSMRVGYTLVKHSQSEQVPPCPIGMSQLWVGYSLL
1440 1450 1460 1470 1480 1490
1520 1530 1540 1550 1560 1570
pF1KB9 YFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPV
. ::::::::::::.::::: :::::::.::: ..::.:: :::::::::::::.:::::
NP_001 FVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPV
1500 1510 1520 1530 1540 1550
1580 1590 1600 1610 1620 1630
pF1KB9 AEDEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQ
.. .: :::::::::::. ::::::::..::.:: :::::::::::::::::: :::::
NP_001 SQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQ
1560 1570 1580 1590 1600 1610
1640 1650 1660 1670 1680 1690
pF1KB9 SLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPE-QSFQGSPSADTLKAGL
::::::::::::::::::::.:.::::::.::::::::::. : :.: : ..:::::
NP_001 SLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGELPVSETLKAGQ
1620 1630 1640 1650 1660 1670
1700 1710
pF1KB9 IRTHISRCQVCMKNL
..:..::::::::.:
NP_001 LHTRVSRCQVCMKSL
1680 1690
>>NP_001836 (OMIM: 120130,175780,180000,607595,611773,61 (1669 aa)
initn: 3801 init1: 939 opt: 4883 Z-score: 1927.5 bits: 369.7 E(85289): 1.3e-100
Smith-Waterman score: 5527; 49.2% identity (63.1% similar) in 1725 aa overlap (10-1710:2-1667)
10 20 30 40 50 60
pF1KB9 MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLAGVKKFDVPCGGRDCSGGCQCYPEKGGR
:: : :::: ... . . :..: :.: : : :.:. :: .
NP_001 MGPRLSVWLLLLPAALLLHEEHSRAAAKG---GCAGSGC-GKCDCHGVKGQK
10 20 30 40
70 80 90 100 110 120
pF1KB9 GQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIP
:. : : :: : ::.:: : :: :.::. : ::. : :: : :.::.:: :.:
NP_001 GERGLPGLQGVIGFPGMQGPEGPQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLP
50 60 70 80 90 100
130 140 150 160 170
pF1KB9 GHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEP-YALPKEER
: ::: :: : :: :::::.:. :: :::: ::.: ::: : :.::.: : .
NP_001 GIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPGEILGHVPG
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB9 DRYRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVK
.:: : ::. : :::: :: : .:: : : ::::::::: :..:. ::.: : :
NP_001 MLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPK
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB9 GEKGDVGQPGPNGIPSDTLHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGISLKGEEGIMG
:.::: : :: :.:... . : : :::::..::::..:. ::.: :
NP_001 GDKGDQGVSGPPGVPGQAQ---VQEKG-DFAT---KGEKGQKGEPGFQGMPGVGEKGEPG
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB9 FPGLRGYPGLSG---EKGSPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPPGLPAYSPHPS
:: :: :: .: :::::: : : : : .::.: ::::: :::::. . . :
NP_001 KPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGPPGPPGI-VIGTGPL
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB9 LAKGARGDPGFPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGLPGEMGPKGFIGDPG
:: :: :: :: .:::: .: :: :: :::::: . :.::: : :: : :
NP_001 GEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGEKG---DRG
350 360 370 380 390
420 430 440 450 460 470
pF1KB9 IPALYGGPPGPDGKRGPPGPPGLPGPPGPDGFLFGL----KGAKGRAGFPGLPGSPGARG
.:. . :::.:. : ::::: ::::: :. :. : : : ::.::.:: :
NP_001 FPGT--SLPGPSGRDGLPGPPGSPGPPGQPGYTNGIVECQPGPPGDQGPPGIPGQPGFIG
400 410 420 430 440 450
480 490 500 510 520 530
pF1KB9 PKGWKGDAGECRCTEGD-EAIKGLPGLPGPKGFAGINGEPGRKGDKGDPGQHGLPGFPGL
: ::. :: : : .. .: :: :: : :. :.:: :::.: ::. :. : ::
NP_001 EIGEKGQKGES-CLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGP
460 470 480 490 500 510
540 550 560 570 580 590
pF1KB9 KGVPGNIGAPGPKGAKGDSR-TITTKGERGQPGVPGVPGMKGDDGSPGRDGLDGFPGLPG
.:.:: :: :: :: :. . ::..:.:: :: ::: : ::::::: :.:: :
NP_001 QGTPGLIGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMPGRAGSPGRDGHPGLPGPKG
520 530 540 550 560 570
600 610 620 630 640
pF1KB9 PPGD-GIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFPGDAGLPGPPGFLGP
::. :.:: : :: :.::..: : :::: : : :.. :.::.:: :: :
NP_001 SPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGPAGPIGDK---GQAGFPGGPGSPGL
580 590 600 610 620 630
650 660 670 680 690 700
pF1KB9 PGPAGTPGQIDCDTDVKRAVGGDRQEAIQPGCIAGPKGLPGLPGPPGPTGAKGLRGIPGF
::: : ::.: : . :: : :::: :: : .: ::.::
NP_001 PGPKGEPGKI------------------VP--LPGPPGAEGLPGSPGFPGPQGDRGFPGT
640 650 660 670
710 720 730 740 750 760
pF1KB9 AGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVGLPGPDGSPGPIGLPGPDGPPGE
: : :: .: :. : ::::::: : : : .: :: : :: :::: : :.
NP_001 PGRPGLPGEKGAVGQPGI-GFPGPPGPKGVDGLPGDMGPPGTPGRPGFNGLPGNPGVQGQ
680 690 700 710 720 730
770 780 790 800 810 820
pF1KB9 RGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPPGFRGSQGMPGMPGLKGQPGLPGPS
.: :: : :: .: :.:: :: : :. : :: : .: : :::.: : :::
NP_001 KGEPGVGL---PGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPP
740 750 760 770 780
830 840 850 860 870 880
pF1KB9 GQPGLYGPPGLHGFPGAPGQEGPLGLPGIPGREGLPGDRGDPGDTGAPGPVGMKGLSGDR
: :: : ::. :. : :: .:: : : :: : :: .:. : : :: . : : .::.
NP_001 GLPGSVGSPGVPGI-GPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPG-LDMPGPKGDK
790 800 810 820 830 840
890 900 910 920 930 940
pF1KB9 GDAGF---TGEQGHPGSPGFKGIDGMPGTPGLKGDRGSPGMDGFQGMPGLKGRPGFPGSK
: :. ::..: :: :: .: :.:: :: ::. : : : : :: : ::.:: :
NP_001 GAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGEMGVMGTPGQPGSPGPVGAPGLPGEK
850 860 870 880 890 900
950 960 970 980 990 1000
pF1KB9 GEAGFFGIPGLKGLAGEPGFKGSRGDPGPPGPPPVILP-GMKDIKGEKGDEGPMGLKGYL
:. :: :: .: :.::.::..:: : :: : . : ..::.:::.: : : .
NP_001 GDHGF---PGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIGPI
910 920 930 940 950 960
1010 1020 1030 1040 1050 1060
pF1KB9 GAKGIQGMPGIPGLSGIPGLPGRPGHIKGVKGDIGVPGIPGLPGFPGVAGPPGITGFPGF
: :: .: :: ::. : : :.::. : ::: :. : :: ::.:: : : :.::
NP_001 GEKGSRGDPGTPGVPGKDGQAGQPGQ-PGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGT
970 980 990 1000 1010 1020
1070 1080 1090 1100 1110 1120
pF1KB9 IGSRGDKGAPG---RAGLYGEIGATGDFGDIGDTINLPGRPGLKGERGTTGIPGLKGFFG
: .: : :: :: :. :: :. :. : : :::.::.: :: :. : :
NP_001 PGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGI--GIPGLRGEKGDQGIAGFPGSPG
1030 1040 1050 1060 1070
1130 1140 1150 1160 1170 1180
pF1KB9 EKGTEGDIGFPGITGVTGVQGPPGLKGQTGFPGLTGPPGSQGELGRIGLPGGKGDDGWPG
::: .:.::.::. : :..: :: : : ::: : :..: : :.:: ::. : ::
NP_001 EKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPG
1080 1090 1100 1110 1120 1130
1190 1200 1210 1220 1230 1240
pF1KB9 APGLPGFPGLRGIRGLHGLPGTKGFPGSPGSDIHGDPGFPGPPGERGDPGEANTLPGPVG
.:: : : .: : :.::. : : :: .: ::::: :..:. ::.. .:: .:
NP_001 TPGPTGPAGQKGEPGSDGIPGSAGEKGEPGLPGRGFPGFPGAKGDKGSKGEVG-FPGLAG
1140 1150 1160 1170 1180 1190
1250 1260 1270 1280 1290 1300
pF1KB9 VPGQKGDQGAPGERGPPGSPGLQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPG
:: :..: : :::: : :.:: .: : ::.: : :: : :: ::::
NP_001 SPGIPGSKGEQGFMGPPGPQGQPGLPG-SPGHATEGPKGDRGPQGQPGLPGLPGPMGPPG
1200 1210 1220 1230 1240 1250
1310 1320 1330 1340 1350
pF1KB9 SAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQGRPGVFGLPG---EKGPRGEQGFMGNTG
.. : ::: :::: ::.::. : :: : :: ::. : :: :: : : : :
NP_001 LPGIDGVKGDKGNPGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGPPGVPGFQG
1260 1270 1280 1290 1300 1310
1360 1370 1380 1390 1400 1410
pF1KB9 PTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVGPQGRRGPPGAPGEM
: : : .: :: .:: : ::: : : :: : . : .:: ::.: ::: : .
NP_001 PKGLPGLQGIKGDQGDQGVPGAKGLPGPPGPPGPYDIIKGEPGLPGPEG---PPGLKGLQ
1320 1330 1340 1350 1360 1370
1420 1430 1440 1450 1460 1470
pF1KB9 GPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLP
: :: :. : : : :: : : ...:: .:. :: : :: : : :: : ::
NP_001 GLPGPKGQQGVTGLVGIPGPPGIPGFDGAPGQKGEMGPAGPTGPRGFPGPPGPDGLPGSM
1380 1390 1400 1410 1420 1430
1480 1490 1500 1510 1520 1530
pF1KB9 GMPGR-SVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCL
: :: ::. :.:...:::: ..:.:: : . :. :::::: .:.:.::.:::: :::::
NP_001 GPPGTPSVDHGFLVTRHSQTIDDPQCPSGTKILYHGYSLLYVQGNERAHGQDLGTAGSCL
1440 1450 1460 1470 1480 1490
1540 1550 1560 1570 1580 1590
pF1KB9 ARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPM--MPVAEDEIKPYISRCSVCEAP
.:::::::.:: ..:: .::::: :::::: :.:: :.. ..:.:.::::.:::::
NP_001 RKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPITGENIRPFISRCAVCEAP
1500 1510 1520 1530 1540 1550
1600 1610 1620 1630 1640 1650
pF1KB9 AIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFI
:...::::: ..:: ::.:: ::::::::.:::.:: ::.::.:.:::::::.::..:::
NP_001 AMVMAVHSQTIQIPPCPSGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRSAPFI
1560 1570 1580 1590 1600 1610
1660 1670 1680 1690 1700 1710
pF1KB9 ECNGGRGTCHYYANKYSFWLTTIPEQSFQGSPSADTLKAGLIRTHISRCQVCMKNL
::.: ::::.:::: :::::.:: .. . .:. .::::: .:::.:::::::.
NP_001 ECHG-RGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRRT
1620 1630 1640 1650 1660
>>XP_011519350 (OMIM: 120130,175780,180000,607595,611773 (1605 aa)
initn: 3697 init1: 939 opt: 4820 Z-score: 1903.1 bits: 365.1 E(85289): 2.9e-99
Smith-Waterman score: 5395; 49.6% identity (63.4% similar) in 1658 aa overlap (77-1710:1-1603)
50 60 70 80 90 100
pF1KB9 CSGGCQCYPEKGGRGQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVG
.:: : :: :.::. : ::. : :: :
XP_011 MQGPEGPQGPPGQKGDTGEPGLPGTKGTRG
10 20 30
110 120 130 140 150 160
pF1KB9 ARGVSGFPGADGIPGHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKG
:.::.:: :.:: ::: :: : :: :::::.:. :: :::: ::.: ::: : :
XP_011 PPGASGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPG
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB9 QKGEP-YALPKEERDRYRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPK
.::.: : . .:: : ::. : :::: :: : .:: : : :::::::::
XP_011 MKGDPGEILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPP
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB9 GQQGNRGLGFYGVKGEKGDVGQPGPNGIPSDTLHPIIAPTGVTFHPDQYKGEKGSEGEPG
:..:. ::.: : ::.::: : :: :.:... . : : :::::..::::
XP_011 GEKGQMGLSFQGPKGDKGDQGVSGPPGVPGQAQ---VQEKG-DF---ATKGEKGQKGEPG
160 170 180 190 200
290 300 310 320 330 340
pF1KB9 IRGISLKGEEGIMGFPGLRGYPGLSG---EKGSPGQKGSRGLDGYQGPDGPRGPKGEAGD
..:. ::.: : :: :: :: .: :::::: : : : : .::.: :::::
XP_011 FQGMPGVGEKGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGP
210 220 230 240 250 260
350 360 370 380 390 400
pF1KB9 PGPPGLPAYSPHPSLAKGARGDPGFPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGL
:::::. . . : :: :: :: :: .:::: .: :: :: :::::: . :.
XP_011 PGPPGI-VIGTGPLGEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLPVPGQAGAPGF
270 280 290 300 310 320
410 420 430 440 450
pF1KB9 PGEMGPKGFIGDPGIPALYGGPPGPDGKRGPPGPPGLPGPPGPDGFLFGL----KGAKGR
::: : :: : :.:. . :::.:. : ::::: ::::: :. :. : :
XP_011 PGERGEKG---DRGFPGT--SLPGPSGRDGLPGPPGSPGPPGQPGYTNGIVECQPGPPGD
330 340 350 360 370
460 470 480 490 500 510
pF1KB9 AGFPGLPGSPGARGPKGWKGDAGECRCTEGD-EAIKGLPGLPGPKGFAGINGEPGRKGDK
: ::.::.:: : : ::. :: : : .. .: :: :: : :. :.:: :::.
XP_011 QGPPGIPGQPGFIGEIGEKGQKGES-CLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDR
380 390 400 410 420 430
520 530 540 550 560 570
pF1KB9 GDPGQHGLPGFPGLKGVPGNIGAPGPKGAKGDSR-TITTKGERGQPGVPGVPGMKGDDGS
: ::. :. : :: .:.:: :: :: :: :. . ::..:.:: :: ::: : ::
XP_011 GLPGRDGVAGVPGPQGTPGLIGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMPGRAGS
440 450 460 470 480 490
580 590 600 610 620 630
pF1KB9 PGRDGLDGFPGLPGPPGD-GIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFP
::::: :.:: : ::. :.:: : :: :.::..: : :::: : : :..:
XP_011 PGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGPAGPIGDKG--
500 510 520 530 540 550
640 650 660 670 680 690
pF1KB9 GDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKRAVGGDRQEAIQPGCIAGPKGLPGLPGPP
.::.:: :: : ::: : ::.: : . :: : :::: :
XP_011 -QAGFPGGPGSPGLPGPKGEPGKI------------------VP--LPGPPGAEGLPGSP
560 570 580 590
700 710 720 730 740 750
pF1KB9 GPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVGLPGPDGSP
: : .: ::.:: : : :: .: :. : ::::::: : : : .: :: : :
XP_011 GFPGPQGDRGFPGTPGRPGLPGEKGAVGQPGI-GFPGPPGPKGVDGLPGDMGPPGTPGRP
600 610 620 630 640 650
760 770 780 790 800 810
pF1KB9 GPIGLPGPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPPGFRGSQGMPG
: :::: : :..: :: : :: .: :.:: :: : :. : :: : .: :
XP_011 GFNGLPGNPGVQGQKGEPGVGL---PGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIG
660 670 680 690 700
820 830 840 850 860 870
pF1KB9 MPGLKGQPGLPGPSGQPGLYGPPGLHGFPGAPGQEGPLGLPGIPGREGLPGDRGDPGDTG
:::.: : ::: : :: : ::. :. : :: .:: : : :: : :: .:. : :
XP_011 PPGLQGIRGEPGPPGLPGSVGSPGVPGI-GPPGARGPPGGQGPPGLSGPPGIKGEKGFPG
710 720 730 740 750 760
880 890 900 910 920 930
pF1KB9 APGPVGMKGLSGDRGDAGF---TGEQGHPGSPGFKGIDGMPGTPGLKGDRGSPGMDGFQG
:: . : : .::.: :. ::..: :: :: .: :.:: :: ::. : : : :
XP_011 FPG-LDMPGPKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGEMGVMGTPGQPG
770 780 790 800 810 820
940 950 960 970 980 990
pF1KB9 MPGLKGRPGFPGSKGEAGFFGIPGLKGLAGEPGFKGSRGDPGPPGPPPVILP-GMKDIKG
:: : ::.:: ::. :: :: .: :.::.::..:: : :: : . : ..::
XP_011 SPGPVGAPGLPGEKGDHGF---PGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKG
830 840 850 860 870 880
1000 1010 1020 1030 1040 1050
pF1KB9 EKGDEGPMGLKGYLGAKGIQGMPGIPGLSGIPGLPGRPGHIKGVKGDIGVPGIPGLPGFP
.:::.: : : .: :: .: :: ::. : : :.::. : ::: :. : :: ::.:
XP_011 QKGDQGEKGQIGPIGEKGSRGDPGTPGVPGKDGQAGQPGQ-PGPKGDPGISGTPGAPGLP
890 900 910 920 930 940
1060 1070 1080 1090 1100
pF1KB9 GVAGPPGITGFPGFIGSRGDKGAPG---RAGLYGEIGATGDFGDIGDTINLPGRPGLKGE
: : : :.:: : .: : :: :: :. :: :. :. : : :::.::
XP_011 GPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGI--GIPGLRGE
950 960 970 980 990 1000
1110 1120 1130 1140 1150 1160
pF1KB9 RGTTGIPGLKGFFGEKGTEGDIGFPGITGVTGVQGPPGLKGQTGFPGLTGPPGSQGELGR
.: :: :. : :::: .:.::.::. : :..: :: : : ::: : :..: :
XP_011 KGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGL
1010 1020 1030 1040 1050 1060
1170 1180 1190 1200 1210 1220
pF1KB9 IGLPGGKGDDGWPGAPGLPGFPGLRGIRGLHGLPGTKGFPGSPGSDIHGDPGFPGPPGER
:.:: ::. : ::.:: : : .: : :.::. : : :: .: ::::: :..
XP_011 DGIPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAGEKGEPGLPGRGFPGFPGAKGDK
1070 1080 1090 1100 1110 1120
1230 1240 1250 1260 1270 1280
pF1KB9 GDPGEANTLPGPVGVPGQKGDQGAPGERGPPGSPGLQGFPGITPPSNISGAPGDKGAPGI
:. ::.. .:: .: :: :..: : :::: : :.:: .: : ::.: :
XP_011 GSKGEVG-FPGLAGSPGIPGSKGEQGFMGPPGPQGQPGLPG-SPGHATEGPKGDRGPQGQ
1130 1140 1150 1160 1170
1290 1300 1310 1320 1330 1340
pF1KB9 FGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQGRPGVFGLPG---E
:: : :: :::: .. : ::: :::: ::.::. : :: : :: ::. : ::
XP_011 PGLPGLPGPMGPPGLPGIDGVKGDKGNPGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGS
1180 1190 1200 1210 1220 1230
1350 1360 1370 1380 1390 1400
pF1KB9 KGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVG
:: : : : :: : : .: :: .:: : ::: : : :: : . : .:: :
XP_011 KGDMGPPGVPGFQGPKGLPGLQGIKGDQGDQGVPGAKGLPGPPGPPGPYDIIKGEPGLPG
1240 1250 1260 1270 1280 1290
1410 1420 1430 1440 1450 1460
pF1KB9 PQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIG
:.: ::: : .: :: :. : : : :: : : ...:: .:. :: : :: :
XP_011 PEG---PPGLKGLQGLPGPKGQQGVTGLVGIPGPPGIPGFDGAPGQKGEMGPAGPTGPRG
1300 1310 1320 1330 1340 1350
1470 1480 1490 1500 1510 1520
pF1KB9 QEGAPGRPGSPGLPGMPGR-SVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLLYFEGQE
: :: : :: : :: ::. :.:...:::: ..:.:: : . :. :::::: .:.:
XP_011 FPGPPGPDGLPGSMGPPGTPSVDHGFLVTRHSQTIDDPQCPSGTKILYHGYSLLYVQGNE
1360 1370 1380 1390 1400 1410
1530 1540 1550 1560 1570 1580
pF1KB9 KAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPM--MPVAEDE
.::.:::: ::::: .:::::::.:: ..:: .::::: :::::: :.:: :.. ..
XP_011 RAHGQDLGTAGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPITGEN
1420 1430 1440 1450 1460 1470
1590 1600 1610 1620 1630 1640
pF1KB9 IKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVS
:.:.::::.::::::...::::: ..:: ::.:: ::::::::.:::.:: ::.::.:.:
XP_011 IRPFISRCAVCEAPAMVMAVHSQTIQIPPCPSGWSSLWIGYSFVMHTSAGAEGSGQALAS
1480 1490 1500 1510 1520 1530
1650 1660 1670 1680 1690 1700
pF1KB9 PGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPEQSFQGSPSADTLKAGLIRTHI
::::::.::..:::::.: ::::.:::: :::::.:: .. . .:. .::::: .:::.
XP_011 PGSCLEEFRSAPFIECHG-RGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHV
1540 1550 1560 1570 1580 1590
1710
pF1KB9 SRCQVCMKNL
:::::::.
XP_011 SRCQVCMRRT
1600
>>XP_011529154 (OMIM: 300914,303631) PREDICTED: collagen (1684 aa)
initn: 3235 init1: 2249 opt: 4779 Z-score: 1886.8 bits: 362.2 E(85289): 2.3e-98
Smith-Waterman score: 5753; 51.2% identity (64.5% similar) in 1738 aa overlap (16-1712:7-1684)
10 20 30 40 50 60
pF1KB9 MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLAGVKKFDVPCGGRDCSGGCQCYPEKGGR
:::: ::. . . . :: :.. ::::.::::.:::.::::.:
XP_011 MLINKLWLLL--VTLCLTEELAAAGEKSYGKPCGGQDCSGSCQCFPEKGAR
10 20 30 40
70 80 90 100 110 120
pF1KB9 GQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIP
:.:::.: :: .:: :. : ::.: ::..: : : ::::: : :: :: : .:::
XP_011 GRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIP
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB9 GHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYALPKEERD
::::: :::: :: :::::::: : :: : :. :::: : ::.::.: : .
XP_011 GHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKG
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB9 RYRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVKG
..:.:: ::: :. :: : :: : .::.: :: :::::::: : .:: :::: : ::
XP_011 -MKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKG
170 180 190 200 210 220
250 260 270 280
pF1KB9 EKGDVGQPGPNGIPSDT--LHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGI---------
::::: ::: : : .: :. . : : ::: : .: ::: :
XP_011 VKGDVGLPGPAGPPPSTGELEFMGFPKG----KKGSKGEPGPKGFPGISGPPGFPGLGTT
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 ---SLKGEEGIMGFPGLRGYPGLSGEKGSPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPP
. :::.:: :.:: :: : : .: :::.:..: :. : .: .: .:. :: : :
XP_011 GEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB9 GLPAY-SPHPSLAKGARGDPG---FPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGL
: .. . .. .: :::: .:: .:. : :: : :.:: :.:: :.
XP_011 GPDVFIDIDGAVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALS--------GV
350 360 370 380 390
410 420 430 440 450
pF1KB9 PGEMGPKGFIG---DPGIPALYG-GPPGPDGKRGPPGPPGLPGPPGPDGFLFGLKGAKGR
:: .::.:: : : : :. : : :. : ::::: ::::.:. :.. .
XP_011 PGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKE--
400 410 420 430 440 450
460 470 480 490 500 510
pF1KB9 AGFPGLPGSPGARGP---KGWKGDAGECRCTEGDEAIKGLPGLPGPKGFAGINGEPGRKG
.::::: : : .: :: :::.: : : .: : :: ::: : :. : :: ::
XP_011 SGFPGLRGEQGPKGNLGLKGIKGDSGFCAC-DGGVPNTGPPGEPGPPGPWGLIGLPGLKG
460 470 480 490 500 510
520 530 540 550 560 570
pF1KB9 DKGDPGQHGLPGFPGLKGVPGNIGAPGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDG
.:: :. : : : :. : .: :::: ::. : .: :. : : :..: :
XP_011 ARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVIG
520 530 540 550 560 570
580 590 600 610 620 630
pF1KB9 SPGRDGLDGFPGLPGPPGDGIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFP
::.::. :.::::: :::: .: ::. : ::.:: :: :: : :: ::::: : ::.:
XP_011 EPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGNGLPGLPGPRGLP
580 590 600 610 620 630
640 650 660 670 680
pF1KB9 GDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKRAVGG---DRQEAIQPGCIA----GPKGL
:: : : :: : :: : :: : :: : ...: :: ::.:.
XP_011 GDKGKDGLPGQQGLPGSKG-----DC---CCREVGKGDLDTERGITLPCIIPGSYGPSGF
640 650 660 670 680
690 700 710 720 730 740
pF1KB9 PGLPGPPGPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVG-
:: :: ::: :: ::.:: : :. : .: ::. : .: ::: :::: :: :
XP_011 PGTPGFPGP---KGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGF
690 700 710 720 730 740
750 760 770 780 790 800
pF1KB9 --LPGPDGSPGPIGLPGPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPP
::: :: :: :: :: :: .: :...::. : :. :. : : ::. :: : :
XP_011 PGLPGKDGLPGMIGSPGL---PGSKGATGDIFGAENGAPGEQGLQGLTGHKGFLGDSGLP
750 760 770 780 790
810 820 830 840 850 860
pF1KB9 GFRGSQGMPGMPGLKGQPGLPGPSGQPGLYGPPGLHGFPGAPGQEGPLGLPGIPGREGLP
:..: .: ::. : ::. : :: :: : : :: : : :. : : ::.:: : :
XP_011 GLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHP
800 810 820 830 840 850
870 880 890 900 910 920
pF1KB9 GDRGDPGDTGAPGPVGMKGLSGDRGDAGFTGEQGHPGSPGFKGIDGMPGTPGLKGDRGSP
: .: : : :: . ::: : .: : : : :::: :. :.:. : ::..::
XP_011 GKKGTRGKKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSGPKGEKGSV
860 870 880 890 900 910
930 940 950 960 970 980
pF1KB9 GMDGFQGMPGLKGRPGFPGSKGEAGFFGIPGLKGLAGEPGFKGSRGDPGPPGPPPVILPG
:. :: :.::: : :: : :: : : : .: :: :: ::.::.::: : : :
XP_011 GFVGFPGIPGLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRP-
920 930 940 950 960 970
990 1000 1010 1020 1030 1040
pF1KB9 MKDI--KGEKGDEGPMGLKGYLGAKGIQGMPGIPGLSGIPGLPGRPGHIKGVKGDIGVPG
:... ::.::..: : .:. : .: .: : :: :.:: :: :: ::::.: : ::
XP_011 MSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPG
980 990 1000 1010 1020 1030
1050 1060 1070 1080 1090 1100
pF1KB9 IPGLPGFPGVAGPPGITGFPGFIGSRGDKGAPGRAGLYGEIGATGDFGDIGDTINLPGRP
. :. :.::. : :::::::. : :..: : :: : : : :: :.:... : :
XP_011 FMGIRGLPGLKGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSP
1040 1050 1060 1070 1080 1090
1110 1120 1130 1140 1150 1160
pF1KB9 GLKGERGTTGIPGLKGFFGEKGTEGDIGFPGITGVTGVQGPPGLKGQTGFPGLTGPPGSQ
: ::. : .:. : : :. : :.::::: : .: :..:..:.:: : ::
XP_011 GPKGQPGESGFKGTK---GRDGLIGNIGFPGNKGE---DGKVGVSGDVGLPGAPGFPGVA
1100 1110 1120 1130 1140 1150
1170 1180 1190 1200 1210 1220
pF1KB9 GELGRIGLPGGKGDDGWPGAPGLPGFPGLRGIRGLHGLPGTKGFPGSPGSDIHGDPGFPG
: :. ::::..: .: : : ::. : .: :. : :: :. :.::
XP_011 GMRGEPGLPGSSGHQGAIGPLGSPGLIGPKG-------PSITGVPG-PA-------GLPG
1160 1170 1180 1190
1230 1240 1250 1260 1270 1280
pF1KB9 PPGERGDPGEANTLPGPVGVPGQKGDQGAPGERGPPGSPGLQGFPGITPPSNISGAPGDK
: ::.: :: . :: :. :::::.: :: .:: : :: :::. :: :.: :::
XP_011 PKGEKGYPGIGIGAPGKPGLRGQKGDRGFPGLQGPAGLPGA---PGISLPSLIAGQPGDP
1200 1210 1220 1230 1240 1250
1290 1300 1310 1320 1330 1340
pF1KB9 GAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQGRPGVFGLP
: ::. : .: :: :::: . ...::::.:: :: :: :: :: :: :: :::
XP_011 GRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGD---QGIPGFSGLP
1260 1270 1280 1290 1300 1310
1350 1360 1370 1380 1390 1400
pF1KB9 GE---KGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQ
:: :: ::: ::::. : .: :: : : :: : :. : : :: . . . :
XP_011 GELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPGQTPTAEAVQVP
1320 1330 1340 1350 1360 1370
1410 1420 1430 1440 1450 1460
pF1KB9 PGTVGPQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGH
:: .: : : :: :. : ::: : : .: :: : .: .:. . :: :: : :
XP_011 PGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGALGDPGLPGL
1380 1390 1400 1410 1420 1430
1470 1480 1490 1500 1510 1520
pF1KB9 QGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLLYF
::: : :::::. : :.:::::.:. .:: ::::::..: : ::.::..:: :::::.
XP_011 QGPPGFEGAPGQQGPFGMPGMPGQSMRVGYTLVKHSQSEQVPPCPIGMSQLWVGYSLLFV
1440 1450 1460 1470 1480 1490
1530 1540 1550 1560 1570 1580
pF1KB9 EGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAE
::::::::::::.::::: :::::::.::: ..::.:: :::::::::::::.:::::..
XP_011 EGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVSQ
1500 1510 1520 1530 1540 1550
1590 1600 1610 1620 1630 1640
pF1KB9 DEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSL
.: :::::::::::. ::::::::..::.:: :::::::::::::::::: :::::::
XP_011 TQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSL
1560 1570 1580 1590 1600 1610
1650 1660 1670 1680 1690
pF1KB9 VSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPE-QSFQGSPSADTLKAGLIR
::::::::::::::::::.:.::::::.::::::::::. : :.: : ..::::: ..
XP_011 VSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGELPVSETLKAGQLH
1620 1630 1640 1650 1660 1670
1700 1710
pF1KB9 THISRCQVCMKNL
:..::::::::.:
XP_011 TRVSRCQVCMKSL
1680
>>NP_001274688 (OMIM: 300914,303631) collagen alpha-6(IV (1666 aa)
initn: 3575 init1: 2249 opt: 4707 Z-score: 1858.8 bits: 357.0 E(85289): 8.5e-97
Smith-Waterman score: 5730; 51.1% identity (64.3% similar) in 1736 aa overlap (11-1712:3-1666)
10 20 30 40 50 60
pF1KB9 MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLAGVKKFDVPCGGRDCSGGCQCYPEKGGR
:.: :::: ::. . . . :: :.. ::::.::::.:::.::::.:
NP_001 MHPGL--WLLL--VTLCLTEELAAAGEKSYGKPCGGQDCSGSCQCFPEKGAR
10 20 30 40
70 80 90 100 110 120
pF1KB9 GQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIP
:.:::.: :: .:: :. : ::.: ::..: : : ::::: : :: :: : .:::
NP_001 GRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIP
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB9 GHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYALPKEERD
::::: :::: :: :::::::: : :: : :. :::: : ::.::.: : .
NP_001 GHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKG
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB9 RYRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVKG
..:.:: ::: :. :: : :: : .::.: :: :::::::: : .:: :::: : ::
NP_001 -MKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKG
170 180 190 200 210 220
250 260 270 280
pF1KB9 EKGDVGQPGPNGIPSDT--LHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGI---------
::::: ::: : : .: :. . : : ::: : .: ::: :
NP_001 VKGDVGLPGPAGPPPSTGELEFMGFPKG----KKGSKGEPGPKGFPGISGPPGFPGLGTT
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 ---SLKGEEGIMGFPGLRGYPGLSGEKGSPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPP
. :::.:: :.:: :: : : .: :::.:..: :. : .: .: .:. :: : :
NP_001 GEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB9 GLPAY-SPHPSLAKGARGDPG---FPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGL
: .. . .. .: :::: .:: .:. : :: : :.:: :.:: :.
NP_001 GPDVFIDIDGAVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALS--------GV
350 360 370 380 390
410 420 430 440 450
pF1KB9 PGEMGPKGFIG---DPGIPALYG-GPPGPDGKRGPPGPPGLPGPPGPDGFLFGLKGAKGR
:: .::.:: : : : :. : : :. : ::::: ::::.:. :.. .
NP_001 PGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKE--
400 410 420 430 440 450
460 470 480 490 500 510
pF1KB9 AGFPGLPGSPGARGP---KGWKGDAGECRCTEGDEAIKGLPGLPGPKGFAGINGEPGRKG
.::::: : : .: :: :::.: : : .: : :: ::: : :. : :: ::
NP_001 SGFPGLRGEQGPKGNLGLKGIKGDSGFCAC-DGGVPNTGPPGEPGPPGPWGLIGLPGLKG
460 470 480 490 500 510
520 530 540 550 560 570
pF1KB9 DKGDPGQHGLPGFPGLKGVPGNIGAPGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDG
.:: :. : : : :. : .: :::: ::. : .: :. : : :..: :
NP_001 ARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVIG
520 530 540 550 560 570
580 590 600 610 620 630
pF1KB9 SPGRDGLDGFPGLPGPPGDGIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFP
::.::. :.::::: :::: .: ::. : ::.:: :: :: : :: ::::: : ::.:
NP_001 EPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGNGLPGLPGPRGLP
580 590 600 610 620 630
640 650 660 670 680 690
pF1KB9 GDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKRAVGGDRQEAIQPGCIAGPKGLPGLPGPP
:: : : :: : :: : . : : :: ::.:.:: :: :
NP_001 GDKGKDGLPGQQGLPGSKGI--TLPC---------------IIPGSY-GPSGFPGTPGFP
640 650 660 670
700 710 720 730 740 750
pF1KB9 GPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVG---LPGPD
:: :: ::.:: : :. : .: ::. : .: ::: :::: :: : ::: :
NP_001 GP---KGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGFPGLPGKD
680 690 700 710 720 730
760 770 780 790 800 810
pF1KB9 GSPGPIGLPGPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPPGFRGSQG
: :: :: :: :: .: :...::. : :. :. : : ::. :: : ::..: .:
NP_001 GLPGMIGSPGL---PGSKGATGDIFGAENGAPGEQGLQGLTGHKGFLGDSGLPGLKGVHG
740 750 760 770 780
820 830 840 850 860 870
pF1KB9 MPGMPGLKGQPGLPGPSGQPGLYGPPGLHGFPGAPGQEGPLGLPGIPGREGLPGDRGDPG
::. : ::. : :: :: : : :: : : :. : : ::.:: : :: .: :
NP_001 KPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHPGKKGTRG
790 800 810 820 830 840
880 890 900 910 920 930
pF1KB9 DTGAPGPVGMKGLSGDRGDAGFTGEQGHPGSPGFKGIDGMPGTPGLKGDRGSPGMDGFQG
: :: . ::: : .: : : : :::: :. :.:. : ::..:: :. :: :
NP_001 KKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSGPKGEKGSVGFVGFPG
850 860 870 880 890 900
940 950 960 970 980 990
pF1KB9 MPGLKGRPGFPGSKGEAGFFGIPGLKGLAGEPGFKGSRGDPGPPGPPPVILPGMKDI--K
.::: : :: : :: : : : .: :: :: ::.::.::: : : : :... :
NP_001 IPGLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRP-MSNLWLK
910 920 930 940 950 960
1000 1010 1020 1030 1040 1050
pF1KB9 GEKGDEGPMGLKGYLGAKGIQGMPGIPGLSGIPGLPGRPGHIKGVKGDIGVPGIPGLPGF
:.::..: : .:. : .: .: : :: :.:: :: :: ::::.: : ::. :. :.
NP_001 GDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMGIRGL
970 980 990 1000 1010 1020
1060 1070 1080 1090 1100 1110
pF1KB9 PGVAGPPGITGFPGFIGSRGDKGAPGRAGLYGEIGATGDFGDIGDTINLPGRPGLKGERG
::. : :::::::. : :..: : :: : : : :: :.:... : :: ::. :
NP_001 PGLKGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPG
1030 1040 1050 1060 1070 1080
1120 1130 1140 1150 1160 1170
pF1KB9 TTGIPGLKGFFGEKGTEGDIGFPGITGVTGVQGPPGLKGQTGFPGLTGPPGSQGELGRIG
.:. : :: . : :.::::: : .: :..:..:.:: : :: : :. :
NP_001 ESGFKGTKG---RDGLIGNIGFPGNK---GEDGKVGVSGDVGLPGAPGFPGVAGMRGEPG
1090 1100 1110 1120 1130 1140
1180 1190 1200 1210 1220 1230
pF1KB9 LPGGKGDDGWPGAPGLPGFPGLRGIRGLHGLPGTKGFPGSPGSDIHGDPGFPGPPGERGD
:::..: .: : : ::. : .: :. : :: :. :.::: ::.:
NP_001 LPGSSGHQGAIGPLGSPGLIGPKG-------PSITGVPG-PA-------GLPGPKGEKGY
1150 1160 1170 1180
1240 1250 1260 1270 1280 1290
pF1KB9 PGEANTLPGPVGVPGQKGDQGAPGERGPPGSPGLQGFPGITPPSNISGAPGDKGAPGIFG
:: . :: :. :::::.: :: .:: : :: :::. :: :.: ::: : ::. :
NP_001 PGIGIGAPGKPGLRGQKGDRGFPGLQGPAGLPGA---PGISLPSLIAGQPGDPGRPGLDG
1190 1200 1210 1220 1230 1240
1300 1310 1320 1330 1340
pF1KB9 LKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQGRPGVFGLPGE---KG
.: :: :::: . ...::::.:: :: :: :: :: :: :: ::::: ::
NP_001 ERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGD---QGIPGFSGLPGELGLKG
1250 1260 1270 1280 1290 1300
1350 1360 1370 1380 1390 1400
pF1KB9 PRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVGPQ
::: ::::. : .: :: : : :: : :. : : :: . . . : :: .:
NP_001 MRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPGQTPTAEAVQVPPGPLGLP
1310 1320 1330 1340 1350 1360
1410 1420 1430 1440 1450 1460
pF1KB9 GRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIGQE
: : :: :. : ::: : : .: :: : .: .:. . :: :: : : ::: : :
NP_001 GIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGALGDPGLPGLQGPPGFE
1370 1380 1390 1400 1410 1420
1470 1480 1490 1500 1510 1520
pF1KB9 GAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLLYFEGQEKAH
::::. : :.:::::.:. .:: ::::::..: : ::.::..:: :::::. :::::::
NP_001 GAPGQQGPFGMPGMPGQSMRVGYTLVKHSQSEQVPPCPIGMSQLWVGYSLLFVEGQEKAH
1430 1440 1450 1460 1470 1480
1530 1540 1550 1560 1570 1580
pF1KB9 NQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEDEIKPYI
:::::.::::: :::::::.::: ..::.:: :::::::::::::.:::::.. .: ::
NP_001 NQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVSQTQIPQYI
1490 1500 1510 1520 1530 1540
1590 1600 1610 1620 1630 1640
pF1KB9 SRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCL
:::::::::. ::::::::..::.:: :::::::::::::::::: ::::::::::::::
NP_001 SRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCL
1550 1560 1570 1580 1590 1600
1650 1660 1670 1680 1690 1700
pF1KB9 EDFRATPFIECNGGRGTCHYYANKYSFWLTTIPE-QSFQGSPSADTLKAGLIRTHISRCQ
:::::::::::.:.::::::.::::::::::. : :.: : ..::::: ..:..::::
NP_001 EDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGELPVSETLKAGQLHTRVSRCQ
1610 1620 1630 1640 1650 1660
1710
pF1KB9 VCMKNL
::::.:
NP_001 VCMKSL
1712 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 22:56:29 2016 done: Thu Nov 3 22:56:32 2016
Total Scan time: 22.080 Total Display time: 0.900
Function used was FASTA [36.3.4 Apr, 2011]