Result of FASTA (omim) for
pFN21ASDA1819
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1819, 1153 aa
1>>>pF1KSDA1819 1153 - 1153 aa - 1153 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.6512+/-0.000463; mu= -14.3055+/- 0.029
mean_var=580.2177+/-123.297, 0's: 0 Z-trim(123.2): 262 B-trim: 1788 in 1/57
Lambda= 0.053245
statistics sampled from 42278 (42586) to 42278 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.759), E-opt: 0.2 (0.499), width: 16
Scan time: 17.370
The best scores are: opt bits E(85289)
NP_115803 (OMIM: 607537) mastermind-like protein 2 (1156) 7778 613.4 2.6e-174
XP_011541325 (OMIM: 607537) PREDICTED: mastermind- (1009) 6613 523.8 2.1e-147
XP_011541326 (OMIM: 607537) PREDICTED: mastermind- ( 928) 6246 495.6 5.9e-139
XP_011541327 (OMIM: 607537) PREDICTED: mastermind- ( 735) 4813 385.4 6.8e-106
NP_061187 (OMIM: 608991) mastermind-like protein 3 (1133) 656 66.3 1.3e-09
NP_005111 (OMIM: 300188,300895,305450,309520) medi (2177) 566 59.6 2.4e-07
NP_055572 (OMIM: 605424) mastermind-like protein 1 (1016) 520 55.8 1.6e-06
NP_001280163 (OMIM: 607372) mediator of RNA polyme ( 731) 506 54.6 2.7e-06
XP_011537078 (OMIM: 147920,602113) PREDICTED: hist (5525) 516 56.1 6.9e-06
XP_006719679 (OMIM: 147920,602113) PREDICTED: hist (5536) 516 56.1 6.9e-06
NP_003473 (OMIM: 147920,602113) histone-lysine N-m (5537) 516 56.1 6.9e-06
XP_005269219 (OMIM: 147920,602113) PREDICTED: hist (5537) 516 56.1 6.9e-06
XP_006719677 (OMIM: 147920,602113) PREDICTED: hist (5540) 516 56.1 6.9e-06
XP_011537076 (OMIM: 147920,602113) PREDICTED: hist (5549) 516 56.1 6.9e-06
XP_011537075 (OMIM: 147920,602113) PREDICTED: hist (5552) 516 56.1 6.9e-06
XP_011537074 (OMIM: 147920,602113) PREDICTED: hist (5553) 516 56.1 6.9e-06
XP_011537073 (OMIM: 147920,602113) PREDICTED: hist (5555) 516 56.1 6.9e-06
XP_011537072 (OMIM: 147920,602113) PREDICTED: hist (5556) 516 56.1 6.9e-06
XP_016884309 (OMIM: 607372) PREDICTED: mediator of ( 667) 465 51.4 2.2e-05
NP_001280166 (OMIM: 607372) mediator of RNA polyme ( 722) 465 51.4 2.4e-05
NP_001280164 (OMIM: 607372) mediator of RNA polyme ( 722) 465 51.4 2.4e-05
NP_056973 (OMIM: 607372) mediator of RNA polymeras ( 748) 465 51.4 2.4e-05
XP_006724327 (OMIM: 607372) PREDICTED: mediator of ( 707) 453 50.5 4.4e-05
XP_016884308 (OMIM: 607372) PREDICTED: mediator of ( 707) 453 50.5 4.4e-05
XP_016884307 (OMIM: 607372) PREDICTED: mediator of ( 707) 453 50.5 4.4e-05
XP_011528517 (OMIM: 607372) PREDICTED: mediator of ( 741) 453 50.5 4.6e-05
XP_016884306 (OMIM: 607372) PREDICTED: mediator of ( 749) 453 50.5 4.6e-05
XP_011528516 (OMIM: 607372) PREDICTED: mediator of ( 762) 453 50.5 4.6e-05
NP_001003891 (OMIM: 607372) mediator of RNA polyme ( 788) 453 50.5 4.8e-05
NP_001280165 (OMIM: 607372) mediator of RNA polyme ( 677) 450 50.2 5e-05
NP_683698 (OMIM: 602081,605317) forkhead box prote ( 732) 439 49.4 9.5e-05
XP_006724326 (OMIM: 607372) PREDICTED: mediator of ( 717) 438 49.3 9.9e-05
XP_016884310 (OMIM: 607372) PREDICTED: mediator of ( 520) 421 47.9 0.00019
NP_683697 (OMIM: 602081,605317) forkhead box prote ( 432) 415 47.4 0.00023
NP_001166238 (OMIM: 602081,605317) forkhead box pr ( 457) 415 47.4 0.00024
XP_016883240 (OMIM: 605299) PREDICTED: nuclear rec (1070) 424 48.4 0.00028
NP_001229468 (OMIM: 605299) nuclear receptor coact (1070) 424 48.4 0.00028
NP_055306 (OMIM: 602081,605317) forkhead box prote ( 715) 415 47.6 0.00034
NP_683696 (OMIM: 602081,605317) forkhead box prote ( 740) 415 47.6 0.00034
XP_016868290 (OMIM: 602081,605317) PREDICTED: fork ( 740) 415 47.6 0.00034
XP_006723818 (OMIM: 605299) PREDICTED: nuclear rec (1975) 424 48.7 0.00044
NP_001305169 (OMIM: 605299) nuclear receptor coact (2063) 424 48.7 0.00045
NP_054790 (OMIM: 605299) nuclear receptor coactiva (2063) 424 48.7 0.00045
XP_011528522 (OMIM: 607372) PREDICTED: mediator of ( 406) 401 46.3 0.00047
XP_011528521 (OMIM: 607372) PREDICTED: mediator of ( 406) 401 46.3 0.00047
XP_016884311 (OMIM: 607372) PREDICTED: mediator of ( 406) 401 46.3 0.00047
NP_001166237 (OMIM: 602081,605317) forkhead box pr ( 714) 408 47.0 0.00049
XP_011528520 (OMIM: 607372) PREDICTED: mediator of ( 411) 397 46.0 0.00059
XP_011527023 (OMIM: 605299) PREDICTED: nuclear rec (2068) 418 48.2 0.00062
NP_001170936 (OMIM: 300120,300758) mastermind-like ( 998) 402 46.7 0.00085
>>NP_115803 (OMIM: 607537) mastermind-like protein 2 [Ho (1156 aa)
initn: 5259 init1: 4423 opt: 7778 Z-score: 3250.4 bits: 613.4 E(85289): 2.6e-174
Smith-Waterman score: 7778; 99.7% identity (99.7% similar) in 1156 aa overlap (1-1153:1-1156)
10 20 30 40 50 60
pF1KSD MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYER
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD GRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD TAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 RKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD LMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPME
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD SRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD PSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD FINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 FINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQ
550 560 570 580 590 600
610 620 630 640 650
pF1KSD QQQQQQQQQQQQQQQQQQ---SSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQ
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_115 QQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQ
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD QQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 QQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVG
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD QNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 QNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLAD
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD AEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 AEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHT
790 800 810 820 830 840
840 850 860 870 880 890
pF1KSD ILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLL
850 860 870 880 890 900
900 910 920 930 940 950
pF1KSD ANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSN
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD TTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQL
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD TPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPP
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KSD SLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGND
1090 1100 1110 1120 1130 1140
1140 1150
pF1KSD DWMKDINLDEILGNNS
::::::::::::::::
NP_115 DWMKDINLDEILGNNS
1150
>>XP_011541325 (OMIM: 607537) PREDICTED: mastermind-like (1009 aa)
initn: 4094 init1: 3796 opt: 6613 Z-score: 2767.5 bits: 523.8 E(85289): 2.1e-147
Smith-Waterman score: 6613; 99.7% identity (99.7% similar) in 985 aa overlap (172-1153:25-1009)
150 160 170 180 190 200
pF1KSD SNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQVVNLSPANSKRPNGFVDNSFL
::::::::::::::::::::::::::::::
XP_011 MLCESEHQAMIFLCSPKSLQFPQNLQGSLKRKQVVNLSPANSKRPNGFVDNSFL
10 20 30 40 50
210 220 230 240 250 260
pF1KSD DIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMG
60 70 80 90 100 110
270 280 290 300 310 320
pF1KSD LKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPM
120 130 140 150 160 170
330 340 350 360 370 380
pF1KSD SDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQ
180 190 200 210 220 230
390 400 410 420 430 440
pF1KSD LRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAA
240 250 260 270 280 290
450 460 470 480 490 500
pF1KSD NRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVA
300 310 320 330 340 350
510 520 530 540 550 560
pF1KSD GGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFH
360 370 380 390 400 410
570 580 590 600 610
pF1KSD FNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ---
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
420 430 440 450 460 470
620 630 640 650 660 670
pF1KSD SSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLR
480 490 500 510 520 530
680 690 700 710 720 730
pF1KSD SPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGY
540 550 560 570 580 590
740 750 760 770 780 790
pF1KSD MNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDY
600 610 620 630 640 650
800 810 820 830 840 850
pF1KSD KDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLS
660 670 680 690 700 710
860 870 880 890 900 910
pF1KSD TAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNN
720 730 740 750 760 770
920 930 940 950 960 970
pF1KSD VATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTS
780 790 800 810 820 830
980 990 1000 1010 1020 1030
pF1KSD AGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTM
840 850 860 870 880 890
1040 1050 1060 1070 1080 1090
pF1KSD GPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTD
900 910 920 930 940 950
1100 1110 1120 1130 1140 1150
pF1KSD HSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
960 970 980 990 1000
>>XP_011541326 (OMIM: 607537) PREDICTED: mastermind-like (928 aa)
initn: 3796 init1: 3796 opt: 6246 Z-score: 2615.7 bits: 495.6 E(85289): 5.9e-139
Smith-Waterman score: 6246; 99.7% identity (99.7% similar) in 928 aa overlap (229-1153:1-928)
200 210 220 230 240 250
pF1KSD SFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLF
::::::::::::::::::::::::::::::
XP_011 MSGTLPMSQAPLRKTNTLPSHTHSPGNGLF
10 20 30
260 270 280 290 300 310
pF1KSD NMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISV
40 50 60 70 80 90
320 330 340 350 360 370
pF1KSD PPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSG
100 110 120 130 140 150
380 390 400 410 420 430
pF1KSD SPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQ
160 170 180 190 200 210
440 450 460 470 480 490
pF1KSD IAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMP
220 230 240 250 260 270
500 510 520 530 540 550
pF1KSD GVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKP
280 290 300 310 320 330
560 570 580 590 600 610
pF1KSD LFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
340 350 360 370 380 390
620 630 640 650 660 670
pF1KSD ---SSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQP
400 410 420 430 440 450
680 690 700 710 720 730
pF1KSD LLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTG
460 470 480 490 500 510
740 750 760 770 780 790
pF1KSD SGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPP
520 530 540 550 560 570
800 810 820 830 840 850
pF1KSD PDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMP
580 590 600 610 620 630
860 870 880 890 900 910
pF1KSD SLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSN
640 650 660 670 680 690
920 930 940 950 960 970
pF1KSD NNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEA
700 710 720 730 740 750
980 990 1000 1010 1020 1030
pF1KSD LTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNG
760 770 780 790 800 810
1040 1050 1060 1070 1080 1090
pF1KSD QTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQ
820 830 840 850 860 870
1100 1110 1120 1130 1140 1150
pF1KSD GTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
880 890 900 910 920
>>XP_011541327 (OMIM: 607537) PREDICTED: mastermind-like (735 aa)
initn: 4823 init1: 4423 opt: 4813 Z-score: 2022.1 bits: 385.4 E(85289): 6.8e-106
Smith-Waterman score: 4813; 97.4% identity (98.0% similar) in 732 aa overlap (1-729:1-732)
10 20 30 40 50 60
pF1KSD MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYER
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD GRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD TAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD LMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPME
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD SRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD PSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD FINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQ
550 560 570 580 590 600
610 620 630 640 650
pF1KSD QQQQQQQQQQQQQQQQQQ---SSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQ
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
XP_011 QQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQ
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD QQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVG
:::::::::::::::::::::::::::::::::::::::::::::::::::::. .:
XP_011 QQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQQPVGVSM
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD QNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLAD
.. : :
XP_011 PDADNIESKCSCKGE
730
>>NP_061187 (OMIM: 608991) mastermind-like protein 3 [Ho (1133 aa)
initn: 1252 init1: 216 opt: 656 Z-score: 293.8 bits: 66.3 E(85289): 1.3e-09
Smith-Waterman score: 1196; 28.7% identity (54.0% similar) in 1259 aa overlap (7-1151:41-1132)
10 20 30
pF1KSD MGDTAPPQAP------AGGLGGASGAGLLGGGSVTP
: :: ::: ::..: : ::....:
NP_061 ANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGPG--GGSAAVP
20 30 40 50 60
40 50 60 70 80 90
pF1KSD RVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAG
. ::..::::: :: ::.::..::.::.....:. . ::..:..: . . . : :.:.:
NP_061 K-HSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLE-QRAKKSG
70 80 90 100 110 120
100 110 120 130 140 150
pF1KSD KHTKATATAATTTAPPPPPAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGI
: .:::
NP_061 AGTG---------------------------------------KQQH------------P
130
160 170 180 190 200 210
pF1KSD NGEQQPPASTPGDQRNSALIALQGSLKRKQVVNLSPANSKRPNGFVDNSFLDIKRIRVGE
. :: .. ..::: .:: :: ..::: :: :. . :: :..: .. :. .
NP_061 SKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSK-RIRK
140 150 160 170 180 190
220 230 240 250 260
pF1KSD NLSAGQGGLQINNGQSQI-MSGTLPMSQAPLRKTNTLP-SHTHSPG--NGLFNMG-LKEV
..:::. . ::: :.. . .. :. : :. . : : ::.:: . : . : : :.
NP_061 DISAGMEA--INNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEI
200 210 220 230 240 250
270 280 290 300 310 320
pF1KSD KKEPGETLSCSKHMDG-QMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDL
: : . .:: :. . : . . .. ::: .: : :. .: ..:
NP_061 KL-PVN--GCSDLEDSFTILQSKDLKQEPLDDP--TCIDTSETSLSNQNKLFSDINLNDQ
260 270 280 290 300
330 340 350 360 370
pF1KSD ELENMINA---TIKQDDP---FNIDLGQQ-----SQRSTPRPSLPMEKIVIKSE--YSPG
: ...:. :. .:: :: :. .. :: .: : : .:. .::. .::
NP_061 EWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETP-LSQESASVKSDPSHSP-
310 320 330 340 350 360
380 390 400 410
pF1KSD LTQGPSGSPQLRPPSAGPAFSMANSALS-------------TSSPI------PSVPQS--
... :::: :: :.:: :: ...: : .::: :..:..
NP_061 FAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAH
370 380 390 400 410 420
420 430 440
pF1KSD ---QAQPQTGSG-------------ASR--ALPSWQEVSHAQQLKQIAANRQQHARM---
:: :. :.: :: :.:: ...: :.::::.::..::.:..
NP_061 TPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPS-SDMSPAEQLKQMAAQQQQRAKLMQQ
430 440 450 460 470 480
450 460 470 480 490
pF1KSD ----------------QQHQQQH--QPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFS
::.:::: : .::: : ..: . : :: :: . :.:.
NP_061 KQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFN
490 500 510 520 530 540
500 510 520 530 540 550
pF1KSD PQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEP
:. .: .:. . :. .: ::. :. .:.... :: :..:. . .:. : .
NP_061 NQNPIVPPMAN-NLQKTTMNNYL----PQ---NHMNMINQQ-PNNLGTNSLNKQHNIL--
550 560 570 580 590
560 570 580 590 600 610
pF1KSD RQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQ
:::::: :::.: .... : : . :: :. : :::::::::::::::::: :
NP_061 TYGNTKPLTHFNADLSQRMTPPV-ANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQL
600 610 620 630 640 650
620 630 640 650 660 670
pF1KSD QQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSL
: . . : ..:.. ..:. ..:: . : :
NP_061 QAPRAHLS--------------------------EDQKRLLLMKQKGVMNQPMAYAA--L
660 670 680
680 690 700 710 720 730
pF1KSD PSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSN
::. . :. : . ::.. : : .:: : ::.
NP_061 PSHGQEQHPVGLPRTT--GPMQSSVPPGSGGMVS---------------GASPA------
690 700 710 720
740 750 760 770 780
pF1KSD PNTGSGYMNSQQ--SLLNQQLMGKKQTLQRQIMEQKQQLLLQQ-QMLADAEKIAPQDQIN
: :...:: ....:.:. .. : : .::::.: .: :. . ..: ..:..
NP_061 ---GPGFLGSQPQAAIMKQMLIDQRAQL---IEQQKQQFLREQRQQQQQQQQILAEQQLQ
730 740 750 760 770
790 800 810 820 830 840
pF1KSD RHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLST
. :. : .. . .:: .: . :..:. . :. .:: . . : ... :.....
NP_061 Q--SHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGI
780 790 800 810 820 830
850 860 870 880 890 900
pF1KSD SHGTRMPSLSTAV--QNMGM--YGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPM
. . ...::. ..::. :.. : .::. :....::.:. :. : . . ..:. .
NP_061 GPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQ
840 850 860 870 880 890
910 920 930 940 950
pF1KSD MPRPPTLGPSNNNNVATFGAGSVGNSQ--QLRPNLTHSMA-SMP----PQRTSNVMITSN
:: :. : .. . :. :: . . :: : .:.. .. ..: : : ...: : .
NP_061 GPRQPASG-QGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQ
900 910 920 930 940 950
960 970 980 990 1000 1010
pF1KSD TTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQL
: .: .. : : ..: : .. :.: : :. : . .:.: :
NP_061 QGAQSWQQR---SLQGMPGRTSGELGPFNNGASY-PLQAGQPRLTKQHFPQ---------
960 970 980 990
1020 1030 1040 1050 1060
pF1KSD TPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNL-NQSGT---------GLN
.::.. . : .: :: : .. :..:.: .:.:: ::.
NP_061 ----------GLSQSVVDANTGTVRTLN--PAAMGRQMMPSLPGQQGTSQARPMVMSGLS
1000 1010 1020 1030 1040
1070 1080 1090 1100 1110 1120
pF1KSD QSRTGI---NQPPSLT--PSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSD
:. :. .:::. ::. .:...:.:.. . .:..... .. . :.: .
NP_061 QGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYE-RNAPQDVSYNYSGDGAGGSFPGLPDG
1050 1060 1070 1080 1090 1100
1130 1140 1150
pF1KSD ADFIDSLLKTEPGNDDWMKDINLDEILGNNS
::..::..: :: :.::.. :::..::
NP_061 ADLVDSIIKGGPG-DEWMQE--LDELFGNP
1110 1120 1130
>>NP_005111 (OMIM: 300188,300895,305450,309520) mediator (2177 aa)
initn: 1190 init1: 408 opt: 566 Z-score: 252.8 bits: 59.6 E(85289): 2.4e-07
Smith-Waterman score: 578; 32.9% identity (54.2% similar) in 474 aa overlap (289-727:1744-2172)
260 270 280 290 300 310
pF1KSD NMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNI--
.: . . :. :..:: . :.
NP_005 VARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPG
1720 1730 1740 1750 1760 1770
320 330 340 350 360 370
pF1KSD SVPPMSDLELENMINATIKQDDPFNI--DLGQQSQRSTPRP-SLPMEKIVIKSEYSPG--
..:: .. : .. . :...: . : :. :: : ..: . . . .::
NP_005 AAPPSTE-ERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLL---HHPNPGSI
1780 1790 1800 1810 1820
380 390 400 410 420
pF1KSD ----LTQGPSG-SPQLRP-PSAGPAFSMANSALSTSSPIPSVPQSQA-QPQTGSGASRAL
:: : : .: :..:: . . . .:. : . : : .:.
NP_005 THLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLE
1830 1840 1850 1860 1870 1880
430 440 450 460 470 480
pF1KSD PSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKI----
:: ..: .: .: :. . : :..:. :: : : .:: ..
NP_005 PSSYKTSVYRQ-QQPAVPQGQ--RLRQQLQQSQ---------------GMLGQSSVHQMT
1890 1900 1910 1920 1930
490 500 510 520
pF1KSD PSPSFGQQT---FSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGH-------LDVL-
:: :.: :: ..: : . :. .: . .:. :.. : :. : .:
NP_005 PSSSYGLQTSQGYTPYVSHV-GLQQHTGPAGTMVPPSYSSQPY-QSTHPSTNPTLVDPTR
1940 1950 1960 1970 1980
530 540 550 560 570 580
pF1KSD -MQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSV-----LPSQNKPSL
.::.:. ..... :.. .:. . : :. :: : . . .:. .
NP_005 HLQQRPS----GYVHQQAPTYGHGLTSTQRFSH----QTLQQTPMISTMTPMSAQGVQAG
1990 2000 2010 2020 2030 2040
590 600 610 620 630 640
pF1KSD LHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQ
.. : .:::::::::::::::::::::::::: : .:::::: : ::::::::
NP_005 VRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHI--RQQQQQQ--ILRQQQQQQQQ
2050 2060 2070 2080 2090
650 660 670 680 690 700
pF1KSD QQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQ
::::::::::::::::::. ..: :. : :: .: .:.. : : .:.: :.. :
NP_005 QQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQ
2100 2110 2120 2130 2140 2150
710 720 730 740 750 760
pF1KSD VSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIME
..:: .:: :.:: :
NP_005 LQQQL---------SNTQPQPSTNIFGRY
2160 2170
>>NP_055572 (OMIM: 605424) mastermind-like protein 1 [Ho (1016 aa)
initn: 444 init1: 187 opt: 520 Z-score: 238.0 bits: 55.8 E(85289): 1.6e-06
Smith-Waterman score: 893; 26.7% identity (53.4% similar) in 1179 aa overlap (30-1151:14-1015)
10 20 30 40 50 60
pF1KSD MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYER
:: :::..:::: :: .::.:: .::.:::
NP_055 MVLPTCPMAEFALPR-HSAVMERLRRRIELCRRHHSTCEARYEA
10 20 30 40
70 80 90 100 110 120
pF1KSD GRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAA
: . ::. :. : . ... :..:::: . :..: : :::: .::
NP_055 VSPERLELERQHTFALHQRCIQAK-AKRAGKHRQPPAATA------PAPAAPAPRLDAAD
50 60 70 80 90
130 140 150 160 170 180
pF1KSD TAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
: . : .. :.:... : . :::.:. . : : ..
NP_055 GPEHGRPATHLHDTVKRNLDSATS------------PQN--GDQQNGYGDLFPGHKKTRR
100 110 120 130 140
190 200 210 220 230 240
pF1KSD VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPL
. :. : :. ::. : : . . .: .:: ..:. .. : ... :
NP_055 EAPLGVAISS--NGLPPASPLGQS------DKPSGADALQ-SSGKHSL--GLDSLNKKRL
150 160 170 180 190
250 260 270 280 290
pF1KSD RKTNTLPSHTHSPGNGLFNMGL-KEVKKEPGETLSCS-KHMDGQMTQENIFPNRYGDDPG
.. . .:... : ..: ::.:.:: : : : :...: :..:.
NP_055 ADSSLHLNGGSNPSES-FPLSLNKELKQEPVEDLPCMITGTVGSISQSNLMPDL------
200 210 220 230 240
300 310 320 330 340 350
pF1KSD EQLMDPELQELFNELTNISVPPMSDLELENMINATIKQD-DPFNIDLGQQSQRSTPRPSL
.: . : .::..:: : ::: : ......: ... :: ..: .: :
NP_055 -NLNEQEWKELIEEL-NRSVP---DEDMKDLFNEDFEEKKDP------ESSGSATQTPL-
250 260 270 280 290
360 370 380 390 400
pF1KSD PMEKIVIKSEYSPG-LTQGPSGSPQLRPPSAGPAFSMANSA-LSTSSPI-----------
. : ::.:.::. . : ::::.: ::: .: .:: .::.::
NP_055 -AQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGPSSAPVSTDSPSLGGSQTLFHTS
300 310 320 330 340 350
410 420 430 440
pF1KSD -------PS---VPQS-QAQPQTGSGASRALPSW-----QEVSHAQQLKQIAANRQQHAR
:: .: : ::: . :. .::: .:.: :.::.:::: .:.. .
NP_055 GQPRADNPSPNLMPASAQAQNAQRALAGVVLPSQGPGGASELSSAHQLQQIAA-KQKREQ
360 370 380 390 400 410
450 460 470 480 490 500
pF1KSD MQQHQQQHQPTNWSALPSS---AGPSPG----PFGQEKIPSPSFGQQTFSPQSS-PMPGV
: :. :: :. . :. .::: . :. .:: ::: .: :. .. ::.:
NP_055 MLQNPQQATPAPAPGQMSTWQQTGPSHSSLDVPYPMEKPASPSSYKQDFTNSKLLMMPSV
420 430 440 450 460 470
510 520 530 540 550 560
pF1KSD AGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLF
.: . .:: : .:...: .: :..:... :: ... ::::::
NP_055 NKSSPRP---------GGPYLQPSHVNLLSHQPPSNLNQNSANNQGSVLD--YGNTKPLS
480 490 500 510
570 580 590 600 610 620
pF1KSD HFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSS
:...: .: :. .:.::.:. : :: .. ...:.. .. . .. . :
NP_055 HYKAD-CGQGSPG--SGQSKPALMAYLPQQLSHISHEQNSLFLMKPKPGNMPFR-----S
520 530 540 550 560 570
630 640 650 660 670 680
pF1KSD ISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSP
. :.:. ::. .: : . : :. . :.: :.:
NP_055 LVPPGQEQNPSSVPVQAQATSVG----------------TQPPAVSVASSHNSSP-----
580 590 600 610
690 700 710 720 730 740
pF1KSD LPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMN
: :::: .. :.
NP_055 ---------------------YLSSQQQ---------------------------AAVMK
620
750 760 770 780 790
pF1KSD SQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQ-MLADAEKIAPQDQINRHLSRPPPDYK
..: ::.:: :: :.: :.::.: .:: .::. :: .:..:::.::::.:.
NP_055 QHQLLLDQQ----KQREQQQKHLQQQQFLQRQQHLLAEQEK----QQFQRHLTRPPPQYQ
630 640 650 660 670
800 810 820 830 840 850
pF1KSD DQRRNVGNM-QPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHG----TRM
: . :.. : ..:..:.:... .. . .: : .. ..:. . : . .
NP_055 DPTQ--GSFPQQVGQFTGSSAAVPGMNTLGPSNS-SCPRVFPQAGNLMPMGPGHASVSSL
680 690 700 710 720 730
860 870 880 890 900 910
pF1KSD PSLSTAVQNMGMY---GNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTL
:. ... :. :. :. : . :...::..:.. : :. :.... .:: ..
NP_055 PT-NSGQQDRGVAQFPGSQNMPQSSLYGMASGITQIVAQPPPQ---ATNGHAHIPRQTNV
740 750 760 770 780
920 930 940 950 960
pF1KSD GPSNNNNVATFGAGSVGNS----QQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQE
: .:.. :..: .:.:.: :. . .:. .... : :.: .: .:.. : :
NP_055 G-QNTSVSAAYGQNSLGSSGLSQQHNKGTLNPGLTKPPVPRVSPAMGGQNSS---WQHQG
790 800 810 820 830 840
970 980 990 1000 1010 1020
pF1KSD GTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQ----RAVAPPNQLTPAVQM
. . .. ...: : . ... .:. . ..: :::: : .:: .. . . ..
NP_055 MPNLSGQTPGNSNVS-PFTAASSFHMQQQAHLKMSSPQFSQAVPNRPMAPMSSAAAVGSL
850 860 870 880 890 900
1030 1040 1050 1060 1070 1080
pF1KSD RPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSN
: . .: .. . .: : : ::.:. .: :. ...: :. . .
NP_055 LPPVSAQQRTSAPAPAP-------PPTAPQQGLPGLSPAGPELG----AFSQSPA-SQMG
910 920 930 940 950
1090 1100 1110 1120 1130 1140
pF1KSD FPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDI
. . ..:. ...: : . .: . . .. . .:.::::::.. ...::.:
NP_055 GRAGLHCTQAYPVRTAGQELPFAYSGQPGGSGLSSVAGHTDLIDSLLKNRT-SEEWMSD-
960 970 980 990 1000
1150
pF1KSD NLDEILGNNS
::..::.
NP_055 -LDDLLGSQ
1010
>>NP_001280163 (OMIM: 607372) mediator of RNA polymerase (731 aa)
initn: 986 init1: 378 opt: 506 Z-score: 234.0 bits: 54.6 E(85289): 2.7e-06
Smith-Waterman score: 518; 32.6% identity (53.0% similar) in 451 aa overlap (487-904:75-489)
460 470 480 490 500 510
pF1KSD QPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYK
: . : . . ...:: . . . . :
NP_001 VFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIG-MPP
50 60 70 80 90 100
520 530 540 550 560 570
pF1KSD AGPSAQ-GGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVL
::. . :: .. . .:..:: ..: :. .. . . :.. :. .:
NP_001 RGPGQSLGGMGSLGAMGQPMSLS----GQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVA
110 120 130 140 150
580 590 600 610
pF1KSD PSQNKPSLLHYTQQQ---QQQQQQQQQQQ--------QQQ-----QQQQQQQQQQQQQQS
.:.. . ::: ::::::::::: ::: ::::: ::::::::
NP_001 LQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQH
160 170 180 190 200 210
620 630 640 650 660 670
pF1KSD SISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRS
:. ..:.::: :. :::: :. : : :::::::::::::: .. :: .:: ...
NP_001 LIKLHHQNQQQ--IQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQ
220 230 240 250 260 270
680 690 700 710 720 730
pF1KSD PLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYM
: : .. : ::.:.. : : : :. :.:: :: : :.. . .
NP_001 PQPPPSQALPQQLQQM----HHTQHHQPPPQPQQPPVAQNQ-PSQLP-----PQSQTQPL
280 290 300 310 320
740 750 760 770 780
pF1KSD NSQQSLLNQQLMGKKQTLQ--RQIMEQKQ---QLLLQQQMLA-----DAEKIAPQDQINR
:: . : :.. . :. : : .: : .:::. : :. .:: :..
NP_001 VSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVQT
330 340 350 360 370 380
790 800 810 820 830 840
pF1KSD HLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTS
: ::: ::. : :. . . ::: ::. .:.: : : :
NP_001 PQSMPPPP-----------QPSPQ--PGQPSSQPNSN------VSSGPAPSPSSFLPSPS
390 400 410 420
850 860 870 880 890 900
pF1KSD -HGTRMPSLSTAVQNMGMYGNLPCNQP-NTYSVTS--GMNQLTQQRNPKQL--LANQNNP
. .. : . . ::... . : : : : :: : : .: .:. .: :.. .:
NP_001 PQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEP
430 440 450 460 470 480
910 920 930 940 950 960
pF1KSD MMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNW
.
NP_001 LRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPP
490 500 510 520 530 540
>>XP_011537078 (OMIM: 147920,602113) PREDICTED: histone- (5525 aa)
initn: 386 init1: 386 opt: 516 Z-score: 226.7 bits: 56.1 E(85289): 6.9e-06
Smith-Waterman score: 631; 25.8% identity (48.4% similar) in 1221 aa overlap (75-1150:3265-4376)
50 60 70 80 90 100
pF1KSD AVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTA
: .:: ..:.. ::.. . . : .
XP_011 KQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLAGSQQQLSLGLAGARQ
3240 3250 3260 3270 3280 3290
110 120 130 140 150
pF1KSD P--PPP--PAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQ--QPPA
: : : :. ::: . : : .: :.: :...::..:. .: ::
XP_011 PGLPQPLMPTQPPAHALQQRLA----PSMAMVSNQGHML-SGQHGGQAGLVPQQSSQPVL
3300 3310 3320 3330 3340
160 170 180 190 200
pF1KSD STPGDQRNSALIALQGSLKRKQVVNLSP-ANSKRPNG----FVDNSFLD-----------
: :. . . . .: .:.. . ::: :. :. ....:
XP_011 S----QKPMGTMPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALK
3350 3360 3370 3380 3390 3400
210 220 230
pF1KSD -IKRI----RVG--------------ENLSAGQGG-LQ--INNGQSQIMSGTLP------
::.. .: . ::.: .. :: . :..: :. :
XP_011 GIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPSSDLQNHVAAGSGQERSAGDPSQPRPN
3410 3420 3430 3440 3450 3460
240 250 260 270 280
pF1KSD --------MSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPG-----ETLSCSKHMDG
...: :. . ::.. :..: :: .... : . :.:. .
XP_011 PPTFAQGVINEADQRQYEEWLFHTQQ----LLQMQLKVLEEQIGVHRKSRKALCAKQRTA
3470 3480 3490 3500 3510 3520
290 300 310 320 330 340
pF1KSD QMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFN
. . .. ::. .: .:. . ... ..: .. .: : . ::.. .
XP_011 KKAGRE-FPE--ADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNL--MAEYRNKQQQQQQ
3530 3540 3550 3560 3570
350 360 370 380 390
pF1KSD IDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPP---SAGPAFSMANSAL
. ::.:.:. : .. . .. : : . .: :: ..: .. .. ::
XP_011 QQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAGGLRLTPGGMAL
3580 3590 3600 3610 3620 3630
400 410 420 430 440
pF1KSD STSSPIP----SVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAAN------RQ---Q
. : .. :.: : ..:...: : :: :.... . :: :
XP_011 PGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGFFPGNLALRSLGPDSRLLQERQLQLQ
3640 3650 3660 3670 3680 3690
450 460 470 480
pF1KSD HARMQ-----QHQQQHQPTNWSALPSSA-------GPSP------GPFGQEKIPSPSFGQ
. ::: :.:::.: . : . : ::. :: : .: :: :
XP_011 QQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMP-PSSHQ
3700 3710 3720 3730 3740 3750
490 500 510 520 530
pF1KSD QTFSPQSSPMP--GVAGGSGQSKVMANYMYKAGP-SAQGGHLDVLMQQK-----PQD---
. : ::.: : : : ..: . . . : . :: : .::: :. ::
XP_011 GLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQ
3760 3770 3780 3790 3800 3810
540 550 560 570 580
pF1KSD ----LSRSFINNPHPAMEPR---QGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQ
... ... . .. . ::. : :.... ... : .: :: . ::
XP_011 GQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQ
3820 3830 3840 3850 3860 3870
590 600 610 620 630 640
pF1KSD QQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQ
:: ::::: ::::::: ::::: :::: : ::::::: .. ::::: :::::: :
XP_011 QQLQQQQQLQQQQQQQLQQQQQLQQQQLQ-----QQQQQQQ--LQQQQQQQLQQQQQQLQ
3880 3890 3900 3910 3920
650 660 670 680 690 700
pF1KSD QQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIA-GMGYQVSQQQ
::::::::: ::: ..: : .. : :: ::.:.: .: : :. .. :
XP_011 QQQQQQQQQFQQQQQQQQMGLLNQSRTLLSP---------QQQQQQQVALGPGMPAKPLQ
3930 3940 3950 3960 3970
710 720 730 740 750
pF1KSD RQDQHSVVG---------QNT-GPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQ
. .. ...: ::: :. : . .:.: .: . . ... . ..
XP_011 HFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTT-PESMATEPGEVK
3980 3990 4000 4010 4020 4030
760 770 780 790 800 810
pF1KSD RQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGS
.. ..: ::.: : :: : . .:: :... .. :: ::.
XP_011 PSLSGDSQLLLVQPQ---------PQPQPSSLQLQPPLRLPGQQQQQVSLLHTA---GGG
4040 4050 4060 4070 4080
820 830 840 850 860 870
pF1KSD STISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTY
: .:.:... : :. : .::.: .: .::...
XP_011 SHGQLGSGSS--------------SEASSVPHLLAQPSVS-----LG-------DQPGSM
4090 4100 4110 4120
880 890 900 910 920 930
pF1KSD SVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLT
. .: : :. : ::: :.:: :: ... . :.: . . ::: .:
XP_011 T----QNLLGPQQ-PMLERPMQNNTG-PQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQ
4130 4140 4150 4160 4170
940 950 960 970 980
pF1KSD HSMASMP------PQRTSNV--MITSNTTAPNWASQEGTSKQQEALTSAGVRF-----PT
.:. : ::. ... .. . . : .. :. . .. .. :
XP_011 GVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQ
4180 4190 4200 4210 4220 4230
990 1000 1010 1020 1030 1040
pF1KSD --GTPAAYT-PNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLR
: :. : : : : : : : :::. :. . . :.. . : : :
XP_011 LGGFPGPQTGPLQELG-AGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQE--PKR
4240 4250 4260 4270 4280 4290
1050 1060 1070 1080 1090
pF1KSD GLNLRPNQL---STQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDH
:.:: :.: ::. : : .. : .: . :. : :.. : :
XP_011 -----PSQLPSPSSQ-LPTEAQ----LPPTHPGTPKPQG--PTLEPPPGRVSPA------
4300 4310 4320 4330
1100 1110 1120 1130 1140 1150
pF1KSD SSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
...:: ..:. ..:: : :.: .:. ... . .::.. :
XP_011 AAQLADTLFSK---GLGPW-----DPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQL
4340 4350 4360 4370 4380
XP_011 SIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQ
4390 4400 4410 4420 4430 4440
>>XP_006719679 (OMIM: 147920,602113) PREDICTED: histone- (5536 aa)
initn: 386 init1: 386 opt: 516 Z-score: 226.7 bits: 56.1 E(85289): 6.9e-06
Smith-Waterman score: 631; 25.8% identity (48.4% similar) in 1221 aa overlap (75-1150:3292-4403)
50 60 70 80 90 100
pF1KSD AVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTA
: .:: ..:.. ::.. . . : .
XP_006 KQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLAGSQQQLSLGLAGARQ
3270 3280 3290 3300 3310 3320
110 120 130 140 150
pF1KSD P--PPP--PAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQ--QPPA
: : : :. ::: . : : .: :.: :...::..:. .: ::
XP_006 PGLPQPLMPTQPPAHALQQRLA----PSMAMVSNQGHML-SGQHGGQAGLVPQQSSQPVL
3330 3340 3350 3360 3370
160 170 180 190 200
pF1KSD STPGDQRNSALIALQGSLKRKQVVNLSP-ANSKRPNG----FVDNSFLD-----------
: :. . . . .: .:.. . ::: :. :. ....:
XP_006 S----QKPMGTMPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALK
3380 3390 3400 3410 3420 3430
210 220 230
pF1KSD -IKRI----RVG--------------ENLSAGQGG-LQ--INNGQSQIMSGTLP------
::.. .: . ::.: .. :: . :..: :. :
XP_006 GIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPSSDLQNHVAAGSGQERSAGDPSQPRPN
3440 3450 3460 3470 3480 3490
240 250 260 270 280
pF1KSD --------MSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPG-----ETLSCSKHMDG
...: :. . ::.. :..: :: .... : . :.:. .
XP_006 PPTFAQGVINEADQRQYEEWLFHTQQ----LLQMQLKVLEEQIGVHRKSRKALCAKQRTA
3500 3510 3520 3530 3540
290 300 310 320 330 340
pF1KSD QMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFN
. . .. ::. .: .:. . ... ..: .. .: : . ::.. .
XP_006 KKAGRE-FPE--ADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNL--MAEYRNKQQQQQQ
3550 3560 3570 3580 3590 3600
350 360 370 380 390
pF1KSD IDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPP---SAGPAFSMANSAL
. ::.:.:. : .. . .. : : . .: :: ..: .. .. ::
XP_006 QQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAGGLRLTPGGMAL
3610 3620 3630 3640 3650 3660
400 410 420 430 440
pF1KSD STSSPIP----SVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAAN------RQ---Q
. : .. :.: : ..:...: : :: :.... . :: :
XP_006 PGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGFFPGNLALRSLGPDSRLLQERQLQLQ
3670 3680 3690 3700 3710 3720
450 460 470 480
pF1KSD HARMQ-----QHQQQHQPTNWSALPSSA-------GPSP------GPFGQEKIPSPSFGQ
. ::: :.:::.: . : . : ::. :: : .: :: :
XP_006 QQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMP-PSSHQ
3730 3740 3750 3760 3770 3780
490 500 510 520 530
pF1KSD QTFSPQSSPMP--GVAGGSGQSKVMANYMYKAGP-SAQGGHLDVLMQQK-----PQD---
. : ::.: : : : ..: . . . : . :: : .::: :. ::
XP_006 GLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQ
3790 3800 3810 3820 3830 3840
540 550 560 570 580
pF1KSD ----LSRSFINNPHPAMEPR---QGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQ
... ... . .. . ::. : :.... ... : .: :: . ::
XP_006 GQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQ
3850 3860 3870 3880 3890 3900
590 600 610 620 630 640
pF1KSD QQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQ
:: ::::: ::::::: ::::: :::: : ::::::: .. ::::: :::::: :
XP_006 QQLQQQQQLQQQQQQQLQQQQQLQQQQLQ-----QQQQQQQ--LQQQQQQQLQQQQQQLQ
3910 3920 3930 3940 3950
650 660 670 680 690 700
pF1KSD QQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIA-GMGYQVSQQQ
::::::::: ::: ..: : .. : :: ::.:.: .: : :. .. :
XP_006 QQQQQQQQQFQQQQQQQQMGLLNQSRTLLSP---------QQQQQQQVALGPGMPAKPLQ
3960 3970 3980 3990 4000
710 720 730 740 750
pF1KSD RQDQHSVVG---------QNT-GPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQ
. .. ...: ::: :. : . .:.: .: . . ... . ..
XP_006 HFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTT-PESMATEPGEVK
4010 4020 4030 4040 4050 4060
760 770 780 790 800 810
pF1KSD RQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGS
.. ..: ::.: : :: : . .:: :... .. :: ::.
XP_006 PSLSGDSQLLLVQPQ---------PQPQPSSLQLQPPLRLPGQQQQQVSLLHTA---GGG
4070 4080 4090 4100 4110
820 830 840 850 860 870
pF1KSD STISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTY
: .:.:... : :. : .::.: .: .::...
XP_006 SHGQLGSGSS--------------SEASSVPHLLAQPSVS-----LG-------DQPGSM
4120 4130 4140
880 890 900 910 920 930
pF1KSD SVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLT
. .: : :. : ::: :.:: :: ... . :.: . . ::: .:
XP_006 T----QNLLGPQQ-PMLERPMQNNTG-PQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQ
4150 4160 4170 4180 4190 4200
940 950 960 970 980
pF1KSD HSMASMP------PQRTSNV--MITSNTTAPNWASQEGTSKQQEALTSAGVRF-----PT
.:. : ::. ... .. . . : .. :. . .. .. :
XP_006 GVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQ
4210 4220 4230 4240 4250 4260
990 1000 1010 1020 1030 1040
pF1KSD --GTPAAYT-PNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLR
: :. : : : : : : : :::. :. . . :.. . : : :
XP_006 LGGFPGPQTGPLQELG-AGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQE--PKR
4270 4280 4290 4300 4310
1050 1060 1070 1080 1090
pF1KSD GLNLRPNQL---STQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDH
:.:: :.: ::. : : .. : .: . :. : :.. : :
XP_006 -----PSQLPSPSSQ-LPTEAQ----LPPTHPGTPKPQG--PTLEPPPGRVSPA------
4320 4330 4340 4350 4360
1100 1110 1120 1130 1140 1150
pF1KSD SSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
...:: ..:. ..:: : :.: .:. ... . .::.. :
XP_006 AAQLADTLFSK---GLGPW-----DPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQL
4370 4380 4390 4400 4410
XP_006 SIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQ
4420 4430 4440 4450 4460 4470
1153 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 19:10:59 2016 done: Thu Nov 3 19:11:01 2016
Total Scan time: 17.370 Total Display time: 0.290
Function used was FASTA [36.3.4 Apr, 2011]