Result of FASTA (omim) for
pFN21AB9097
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9097, 1366 aa
1>>>pF1KB9097 1366 - 1366 aa - 1366 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.2376+/-0.000747; mu= -4.1320+/- 0.045
mean_var=830.2996+/-187.535, 0's: 0 Z-trim(114.3): 812 B-trim: 0 in 0/53
Lambda= 0.044510
statistics sampled from 23191 (24030) to 23191 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.619), E-opt: 0.2 (0.282), width: 16
Scan time: 11.410
The best scores are: opt bits E(85289)
NP_001278787 (OMIM: 147370,270450) insulin-like gr (1366) 9360 619.6 4.9e-176
NP_000866 (OMIM: 147370,270450) insulin-like growt (1367) 9340 618.3 1.2e-175
XP_016877627 (OMIM: 147370,270450) PREDICTED: insu (1391) 9155 606.4 4.5e-172
XP_016877626 (OMIM: 147370,270450) PREDICTED: insu (1392) 9135 605.2 1.1e-171
XP_016877625 (OMIM: 147370,270450) PREDICTED: insu (1392) 9135 605.2 1.1e-171
XP_016877628 (OMIM: 147370,270450) PREDICTED: insu (1246) 8534 566.5 4.3e-160
XP_011519818 (OMIM: 147370,270450) PREDICTED: insu (1064) 7184 479.7 4.9e-134
XP_011519819 (OMIM: 147370,270450) PREDICTED: insu ( 922) 6221 417.7 1.9e-115
XP_011526291 (OMIM: 147670,246200,262190,609968,61 (1369) 4631 315.9 1.3e-84
NP_001073285 (OMIM: 147670,246200,262190,609968,61 (1370) 4162 285.8 1.5e-75
XP_011526290 (OMIM: 147670,246200,262190,609968,61 (1381) 2423 174.1 6.1e-42
NP_000199 (OMIM: 147670,246200,262190,609968,61054 (1382) 2410 173.3 1.1e-41
NP_055030 (OMIM: 147671) insulin receptor-related (1297) 2325 167.8 4.6e-40
NP_004295 (OMIM: 105590,613014) ALK tyrosine kinas (1620) 939 79.0 3.2e-13
NP_996844 (OMIM: 151520) leukocyte tyrosine kinase ( 803) 889 75.3 2.1e-12
XP_011519859 (OMIM: 151520) PREDICTED: leukocyte t ( 824) 889 75.3 2.1e-12
XP_016877671 (OMIM: 151520) PREDICTED: leukocyte t ( 837) 889 75.3 2.1e-12
NP_002335 (OMIM: 151520) leukocyte tyrosine kinase ( 864) 889 75.3 2.2e-12
XP_011519858 (OMIM: 151520) PREDICTED: leukocyte t ( 880) 889 75.3 2.2e-12
XP_016877670 (OMIM: 151520) PREDICTED: leukocyte t ( 885) 889 75.3 2.2e-12
XP_011534355 (OMIM: 165020) PREDICTED: proto-oncog (2299) 899 76.7 2.3e-12
XP_016866662 (OMIM: 165020) PREDICTED: proto-oncog (2333) 899 76.7 2.3e-12
XP_016866661 (OMIM: 165020) PREDICTED: proto-oncog (2334) 899 76.7 2.3e-12
XP_006715611 (OMIM: 165020) PREDICTED: proto-oncog (2342) 899 76.7 2.3e-12
XP_011534354 (OMIM: 165020) PREDICTED: proto-oncog (2343) 899 76.7 2.3e-12
NP_002935 (OMIM: 165020) proto-oncogene tyrosine-p (2347) 899 76.7 2.3e-12
XP_011534353 (OMIM: 165020) PREDICTED: proto-oncog (2348) 899 76.7 2.3e-12
XP_011534352 (OMIM: 165020) PREDICTED: proto-oncog (2356) 899 76.7 2.3e-12
XP_011534351 (OMIM: 165020) PREDICTED: proto-oncog (2357) 899 76.7 2.3e-12
XP_011517020 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 847 72.6 1.4e-11
NP_001018074 (OMIM: 600456,613886) BDNF/NT-3 growt ( 822) 847 72.6 1.4e-11
XP_016870241 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 847 72.6 1.4e-11
XP_016870243 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 847 72.6 1.4e-11
XP_016870242 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 847 72.6 1.4e-11
XP_016870240 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 847 72.6 1.4e-11
XP_005252060 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 847 72.6 1.4e-11
XP_005252058 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 847 72.6 1.4e-11
NP_006171 (OMIM: 600456,613886) BDNF/NT-3 growth f ( 838) 847 72.6 1.4e-11
XP_005252061 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 847 72.6 1.4e-11
NP_001007793 (OMIM: 155240,191315,256800) high aff ( 760) 836 71.8 2.1e-11
NP_001012331 (OMIM: 155240,191315,256800) high aff ( 790) 836 71.8 2.2e-11
NP_002520 (OMIM: 155240,191315,256800) high affini ( 796) 836 71.8 2.2e-11
XP_016877741 (OMIM: 191316) PREDICTED: NT-3 growth ( 448) 819 70.3 3.5e-11
XP_016877740 (OMIM: 191316) PREDICTED: NT-3 growth ( 456) 819 70.3 3.5e-11
XP_016877733 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 819 70.7 4.5e-11
XP_016877732 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 819 70.7 4.5e-11
XP_016877735 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 819 70.7 4.5e-11
XP_016877734 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 819 70.7 4.5e-11
XP_016877730 (OMIM: 191316) PREDICTED: NT-3 growth ( 763) 819 70.7 4.6e-11
NP_001230030 (OMIM: 191316) NT-3 growth factor rec ( 817) 819 70.8 4.7e-11
>>NP_001278787 (OMIM: 147370,270450) insulin-like growth (1366 aa)
initn: 9360 init1: 9360 opt: 9360 Z-score: 3281.5 bits: 619.6 E(85289): 4.9e-176
Smith-Waterman score: 9360; 100.0% identity (100.0% similar) in 1366 aa overlap (1-1366:1-1366)
10 20 30 40 50 60
pF1KB9 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 APDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 NNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 NYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB9 VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFES
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB9 RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB9 EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB9 YTARIQATSLSGNGSWTDPVFFYVQAKRYENFIHLIIALPVAVLLIVGGLVIMLYVFHRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTARIQATSLSGNGSWTDPVFFYVQAKRYENFIHLIIALPVAVLLIVGGLVIMLYVFHRK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB9 RNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB9 VKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMEL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB9 MTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNC
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB9 MVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVV
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB9 LWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB9 IISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHS
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360
pF1KB9 GHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
1330 1340 1350 1360
>>NP_000866 (OMIM: 147370,270450) insulin-like growth fa (1367 aa)
initn: 6428 init1: 6428 opt: 9340 Z-score: 3274.5 bits: 618.3 E(85289): 1.2e-175
Smith-Waterman score: 9340; 99.9% identity (99.9% similar) in 1367 aa overlap (1-1366:1-1367)
10 20 30 40 50 60
pF1KB9 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 APDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 APDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 NNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 NYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB9 VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFES
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB9 RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB9 EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
850 860 870 880 890 900
910 920 930 940 950
pF1KB9 YTARIQATSLSGNGSWTDPVFFYVQAKR-YENFIHLIIALPVAVLLIVGGLVIMLYVFHR
::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
NP_000 YTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHR
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KB9 KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KB9 VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KB9 LMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KB9 CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB9 VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KB9 EIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRH
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360
pF1KB9 SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
:::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
1330 1340 1350 1360
>>XP_016877627 (OMIM: 147370,270450) PREDICTED: insulin- (1391 aa)
initn: 9151 init1: 9151 opt: 9155 Z-score: 3210.3 bits: 606.4 E(85289): 4.5e-172
Smith-Waterman score: 9155; 98.5% identity (98.8% similar) in 1363 aa overlap (10-1366:29-1391)
10 20 30
pF1KB9 MKSGSGGGSPTSLWG---LLFLSA---ALSLWPTSGEICGP
: . : :: :: : .: : ..:::
XP_016 MSIPSWSGPWLPEQEKASVRWEASCSVLPDAGWCEKELLSCSAPWIAQGLPETRIQVCGP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 GIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLES
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 LGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTV
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB9 DWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMC
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB9 PSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWR
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB9 CVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEE
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB9 KKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB9 LVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLC
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB9 VSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPP
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB9 DYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWT
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB9 QYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPS
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB9 LPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGE
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB9 KGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSR
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB9 NTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGC
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB9 SASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVED
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB9 QRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKRYENFIHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKRYENFIHL
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB9 IIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAR
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KB9 EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKE
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KB9 FNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMA
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KB9 GEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KB9 RWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDN
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KB9 CPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLE
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KB9 PENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNE
1330 1340 1350 1360 1370 1380
1360
pF1KB9 RALPLPQSSTC
:::::::::::
XP_016 RALPLPQSSTC
1390
>>XP_016877626 (OMIM: 147370,270450) PREDICTED: insulin- (1392 aa)
initn: 6219 init1: 6219 opt: 9135 Z-score: 3203.3 bits: 605.2 E(85289): 1.1e-171
Smith-Waterman score: 9135; 98.4% identity (98.7% similar) in 1364 aa overlap (10-1366:29-1392)
10 20 30
pF1KB9 MKSGSGGGSPTSLWG---LLFLSA---ALSLWPTSGEICGP
: . : :: :: : .: : ..:::
XP_016 MSIPSWSGPWLPEQEKASVRWEASCSVLPDAGWCEKELLSCSAPWIAQGLPETRIQVCGP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 GIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLES
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 LGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTV
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB9 DWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMC
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB9 PSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWR
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB9 CVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEE
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB9 KKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB9 LVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLC
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB9 VSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPP
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB9 DYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWT
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB9 QYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPS
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB9 LPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGE
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB9 KGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSR
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB9 NTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGC
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB9 SASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVED
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB9 QRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKR-YENFIH
:::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_016 QRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIH
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB9 LIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVA
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KB9 REKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMK
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KB9 EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQM
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KB9 AGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLP
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KB9 VRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPD
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KB9 NCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDL
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KB9 EPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKN
1330 1340 1350 1360 1370 1380
1360
pF1KB9 ERALPLPQSSTC
::::::::::::
XP_016 ERALPLPQSSTC
1390
>>XP_016877625 (OMIM: 147370,270450) PREDICTED: insulin- (1392 aa)
initn: 6219 init1: 6219 opt: 9135 Z-score: 3203.3 bits: 605.2 E(85289): 1.1e-171
Smith-Waterman score: 9135; 98.4% identity (98.7% similar) in 1364 aa overlap (10-1366:29-1392)
10 20 30
pF1KB9 MKSGSGGGSPTSLWG---LLFLSA---ALSLWPTSGEICGP
: . : :: :: : .: : ..:::
XP_016 MSIPSWSGPWLPEQEKASVRWEASCSVLPDAGWCEKELLSCSAPWIAQGLPETRIQVCGP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 GIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLES
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 LGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTV
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB9 DWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMC
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB9 PSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWR
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB9 CVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEE
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB9 KKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB9 LVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLC
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB9 VSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPP
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB9 DYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWT
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB9 QYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPS
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB9 LPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGE
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB9 KGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSR
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB9 NTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGC
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB9 SASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVED
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB9 QRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKR-YENFIH
:::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_016 QRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIH
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB9 LIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVA
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KB9 REKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMK
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KB9 EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQM
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KB9 AGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLP
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KB9 VRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPD
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KB9 NCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDL
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KB9 EPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKN
1330 1340 1350 1360 1370 1380
1360
pF1KB9 ERALPLPQSSTC
::::::::::::
XP_016 ERALPLPQSSTC
1390
>>XP_016877628 (OMIM: 147370,270450) PREDICTED: insulin- (1246 aa)
initn: 5622 init1: 5622 opt: 8534 Z-score: 2995.2 bits: 566.5 E(85289): 4.3e-160
Smith-Waterman score: 8534; 99.8% identity (99.8% similar) in 1246 aa overlap (122-1366:1-1246)
100 110 120 130 140 150
pF1KB9 GLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCY
::::::::::::::::::::::::::::::
XP_016 MTNLKDIGLYNLRNITRGAIRIEKNADLCY
10 20 30
160 170 180 190 200 210
pF1KB9 LSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRC
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB9 QKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRF
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB9 EGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKV
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB9 CEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIR
220 230 240 250 260 270
400 410 420 430 440 450
pF1KB9 HSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFN
280 290 300 310 320 330
460 470 480 490 500 510
pF1KB9 PKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHR
340 350 360 370 380 390
520 530 540 550 560 570
pF1KB9 YRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGL
400 410 420 430 440 450
580 590 600 610 620 630
pF1KB9 KPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKW
460 470 480 490 500 510
640 650 660 670 680 690
pF1KB9 NPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEV
520 530 540 550 560 570
700 710 720 730 740 750
pF1KB9 CGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMS
580 590 600 610 620 630
760 770 780 790 800 810
pF1KB9 SRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAE
640 650 660 670 680 690
820 830 840 850 860 870
pF1KB9 KLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGS
700 710 720 730 740 750
880 890 900 910 920 930
pF1KB9 QVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKR-YE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 QVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYE
760 770 780 790 800 810
940 950 960 970 980 990
pF1KB9 NFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDE
820 830 840 850 860 870
1000 1010 1020 1030 1040 1050
pF1KB9 WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEA
880 890 900 910 920 930
1060 1070 1080 1090 1100 1110
pF1KB9 SVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSK
940 950 960 970 980 990
1120 1130 1140 1150 1160 1170
pF1KB9 MIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGK
1000 1010 1020 1030 1040 1050
1180 1190 1200 1210 1220 1230
pF1KB9 GLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLL
1060 1070 1080 1090 1100 1110
1240 1250 1260 1270 1280 1290
pF1KB9 DKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPE
1120 1130 1140 1150 1160 1170
1300 1310 1320 1330 1340 1350
pF1KB9 ELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNG
1180 1190 1200 1210 1220 1230
1360
pF1KB9 GRKNERALPLPQSSTC
::::::::::::::::
XP_016 GRKNERALPLPQSSTC
1240
>>XP_011519818 (OMIM: 147370,270450) PREDICTED: insulin- (1064 aa)
initn: 4272 init1: 4272 opt: 7184 Z-score: 2527.3 bits: 479.7 E(85289): 4.9e-134
Smith-Waterman score: 7184; 99.8% identity (99.8% similar) in 1064 aa overlap (304-1366:1-1064)
280 290 300 310 320 330
pF1KB9 WRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCE
::::::::::::::::::::::::::::::
XP_011 MQECPSGFIRNGSQSMYCIPCEGPCPKVCE
10 20 30
340 350 360 370 380 390
pF1KB9 EEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHS
40 50 60 70 80 90
400 410 420 430 440 450
pF1KB9 HALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPK
100 110 120 130 140 150
460 470 480 490 500 510
pF1KB9 LCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYR
160 170 180 190 200 210
520 530 540 550 560 570
pF1KB9 PPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKP
220 230 240 250 260 270
580 590 600 610 620 630
pF1KB9 WTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNP
280 290 300 310 320 330
640 650 660 670 680 690
pF1KB9 PSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCG
340 350 360 370 380 390
700 710 720 730 740 750
pF1KB9 GEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSR
400 410 420 430 440 450
760 770 780 790 800 810
pF1KB9 SRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKL
460 470 480 490 500 510
820 830 840 850 860 870
pF1KB9 GCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQV
520 530 540 550 560 570
880 890 900 910 920 930
pF1KB9 EDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKR-YENF
:::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 EDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENF
580 590 600 610 620 630
940 950 960 970 980 990
pF1KB9 IHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWE
640 650 660 670 680 690
1000 1010 1020 1030 1040 1050
pF1KB9 VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASV
700 710 720 730 740 750
1060 1070 1080 1090 1100 1110
pF1KB9 MKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMI
760 770 780 790 800 810
1120 1130 1140 1150 1160 1170
pF1KB9 QMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGL
820 830 840 850 860 870
1180 1190 1200 1210 1220 1230
pF1KB9 LPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDK
880 890 900 910 920 930
1240 1250 1260 1270 1280 1290
pF1KB9 PDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEEL
940 950 960 970 980 990
1300 1310 1320 1330 1340 1350
pF1KB9 DLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGR
1000 1010 1020 1030 1040 1050
1360
pF1KB9 KNERALPLPQSSTC
::::::::::::::
XP_011 KNERALPLPQSSTC
1060
>>XP_011519819 (OMIM: 147370,270450) PREDICTED: insulin- (922 aa)
initn: 3309 init1: 3309 opt: 6221 Z-score: 2193.6 bits: 417.7 E(85289): 1.9e-115
Smith-Waterman score: 6221; 99.8% identity (99.8% similar) in 922 aa overlap (446-1366:1-922)
420 430 440 450 460 470
pF1KB9 GNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKG
::::::::::::::::::::::::::::::
XP_011 MYFAFNPKLCVSEIYRMEEVTGTKGRQSKG
10 20 30
480 490 500 510 520 530
pF1KB9 DINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNV
40 50 60 70 80 90
540 550 560 570 580 590
pF1KB9 TEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIR
100 110 120 130 140 150
600 610 620 630 640 650
pF1KB9 GAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDG
160 170 180 190 200 210
660 670 680 690 700 710
pF1KB9 YLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEE
220 230 240 250 260 270
720 730 740 750 760 770
pF1KB9 AEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEY
280 290 300 310 320 330
780 790 800 810 820 830
pF1KB9 PFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIP
340 350 360 370 380 390
840 850 860 870 880 890
pF1KB9 GPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNR
400 410 420 430 440 450
900 910 920 930 940 950
pF1KB9 LNPGNYTARIQATSLSGNGSWTDPVFFYVQAKR-YENFIHLIIALPVAVLLIVGGLVIML
:::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_011 LNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIML
460 470 480 490 500 510
960 970 980 990 1000 1010
pF1KB9 YVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYE
520 530 540 550 560 570
1020 1030 1040 1050 1060 1070
pF1KB9 GVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPT
580 590 600 610 620 630
1080 1090 1100 1110 1120 1130
pF1KB9 LVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRD
640 650 660 670 680 690
1140 1150 1160 1170 1180 1190
pF1KB9 LAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDV
700 710 720 730 740 750
1200 1210 1220 1230 1240 1250
pF1KB9 WSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKM
760 770 780 790 800 810
1260 1270 1280 1290 1300 1310
pF1KB9 RPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLP
820 830 840 850 860 870
1320 1330 1340 1350 1360
pF1KB9 LPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
880 890 900 910 920
>>XP_011526291 (OMIM: 147670,246200,262190,609968,610549 (1369 aa)
initn: 3602 init1: 1796 opt: 4631 Z-score: 1640.3 bits: 315.9 E(85289): 1.3e-84
Smith-Waterman score: 5386; 58.0% identity (80.6% similar) in 1373 aa overlap (17-1364:21-1367)
10 20 30 40 50
pF1KB9 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIE
:.:.:: :.: ::.: ::.::::. .:..::::.:::
XP_011 MATGGRRGAAAAPLLVAVAALLLGAAGHLYP--GEVC-PGMDIRNNLTRLHELENCSVIE
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 GYLHILLI--SKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYN
:.:.:::. .. ::.:. :::: .::.::::::: ::::: ::::::::::: .::.:
XP_011 GHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 YALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKP
::::::::..::..::::: :::::..::::: .::::.:.::: :::.: .:::: ::
XP_011 YALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 P-KECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHP
.::::.:::: . : : :.::... :::: ..:::.::. : ...:: .. :::
XP_011 DNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB9 ECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANIL-SAESSD
::::.:: ::. : :::::..: : :: .::: :.:. ::::. .:: .. . ..:
XP_011 ECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSR
240 250 260 270 280 290
300 310 320 330 340
pF1KB9 SEG---FVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQM
.: .:::...:. :::::. : :... : :: :::::::. . ::::::::::
XP_011 RQGCHQYVIHNNKCIPECPSGYTMN-SSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQE
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB9 LQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLIL
:.:::...:.:.:::: :::.:.::: .:::: ..::.:::.:.:::::::...::::
XP_011 LRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIR
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB9 GEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTK
:: ::::::.::::::.:::::...:::: ::..: .:::::.:::..::::.:::
XP_011 GETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTK
420 430 440 450 460 470
470 480 490 500 510 520
pF1KB9 GRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKE
::: ..:: ..::..::::...:.:. :: ..:.. :. : :::.:::..: ..:::
XP_011 GRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKE
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB9 APFKNVTEYDGQDACGSNSWNMVDVDLP-----PNKDVEPGILLHGLKPWTQYAVYVKAV
::..::::.:::::::::::..::.: : :... .:: :..:::::::::..::..
XP_011 APYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTL
540 550 560 570 580 590
590 600 610 620 630 640
pF1KB9 TLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYY
.:. .. . ::::.:.:..:.:. ::.::: .:.::::::.:.::.::: ::::...:
XP_011 -VTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHY
600 610 620 630 640 650
650 660 670 680 690 700
pF1KB9 IVRWQRQPQDGYLYRHNYCSKD-KIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACP
.: :.:: .:. :.. .:: : :.: : .. .. :. .. ..: . : ::.::
XP_011 LVFWERQAEDSELFELDYCLKGLKLPSRTWSP-PFESEDSQKHNQSEYEDSA-GECCSCP
660 670 680 690 700 710
710 720 730 740 750 760
pF1KB9 KTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAA--D
::... : ::. .::.::..::: .::::: ::::.. .:.:.:.. :.:: .
XP_011 KTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGDVGNVTVAV---PTVAAFPN
720 730 740 750 760 770
770 780 790 800 810 820
pF1KB9 TYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFV
: . . : : . :: .: ::: :::.:: :: :::....::... . ::.. .:
XP_011 TSSTSVPTSPEEHRPF--EKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV
780 790 800 810 820
830 840 850 860 870
pF1KB9 FARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEI---KYGSQVEDQRE
::::: :::: :::: : .: . : : ::..:::::..::. .::. :. .
XP_011 SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGD--EELHL
830 840 850 860 870 880
880 890 900 910 920 930
pF1KB9 CVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKRYENFIHLIIA
::::... : .: :.::::..::.::::.::::::.:..::: . : ::
XP_011 CVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYYVPSNIAKIII
890 900 910 920 930 940
940 950 960 970 980 990
pF1KB9 LPVAVLLIVGGLVIMLYVFHRKRN-NSRLGNGVLYASVNPEYFSAADV-----YVPDEWE
:. ... . .. .:.: :::. .. :: :::: ::::.::.:: :::::::
XP_011 GPLIFVFLFSVVIGSIYLFLRKRQPDGPLGP--LYASSNPEYLSASDVFPCSVYVPDEWE
950 960 970 980 990 1000
1000 1010 1020 1030 1040 1050
pF1KB9 VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASV
:.:::::. :::::::::::::: :. ..: : :::::.:::::.::.::::::::::::
XP_011 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV
1010 1020 1030 1040 1050 1060
1060 1070 1080 1090 1100 1110
pF1KB9 MKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMI
:: :.::::::::::::.::::::.::::..::::::::::::: :::: ::.:..::
XP_011 MKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMI
1070 1080 1090 1100 1110 1120
1120 1130 1140 1150 1160 1170
pF1KB9 QMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGL
:::.:::::::::::.:::::::::::::::.::::::::::::::::::::::::::::
XP_011 QMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGL
1130 1140 1150 1160 1170 1180
1180 1190 1200 1210 1220 1230
pF1KB9 LPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDK
::::::.::::::::::: ::.::::::::::..:::::::::::::::.:::.:: ::.
XP_011 LPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQ
1190 1200 1210 1220 1230 1240
1240 1250 1260 1270 1280 1290
pF1KB9 PDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEEL
:::::. . .:::::::.::::::.::::.. .:....:.: ::::..::::: :: :::
XP_011 PDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEEL
1250 1260 1270 1280 1290 1300
1300 1310 1320 1330 1340 1350
pF1KB9 DLEPENMESVPLDPSASSSSLPLPDRHSGHKAENG-PGPGVLVLRASFDERQPYAHMNGG
..: :.::.:::: :. : .. .: : . : .. :..:. ::.:::::
XP_011 EMEFEDMENVPLDRSS----------HCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGG
1310 1320 1330 1340 1350
1360
pF1KB9 RKNERALPLPQSSTC
.:: : : ::.:.
XP_011 KKNGRILTLPRSNPS
1360
>>NP_001073285 (OMIM: 147670,246200,262190,609968,610549 (1370 aa)
initn: 3830 init1: 1796 opt: 4162 Z-score: 1477.5 bits: 285.8 E(85289): 1.5e-75
Smith-Waterman score: 5373; 58.0% identity (80.6% similar) in 1374 aa overlap (17-1364:21-1368)
10 20 30 40 50
pF1KB9 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIE
:.:.:: :.: ::.: ::.::::. .:..::::.:::
NP_001 MATGGRRGAAAAPLLVAVAALLLGAAGHLYP--GEVC-PGMDIRNNLTRLHELENCSVIE
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 GYLHILLI--SKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYN
:.:.:::. .. ::.:. :::: .::.::::::: ::::: ::::::::::: .::.:
NP_001 GHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 YALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKP
::::::::..::..::::: :::::..::::: .::::.:.::: :::.: .:::: ::
NP_001 YALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 P-KECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHP
.::::.:::: . : : :.::... :::: ..:::.::. : ...:: .. :::
NP_001 DNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB9 ECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANIL-SAESSD
::::.:: ::. : :::::..: : :: .::: :.:. ::::. .:: .. . ..:
NP_001 ECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSR
240 250 260 270 280 290
300 310 320 330 340
pF1KB9 SEG---FVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQM
.: .:::...:. :::::. : :... : :: :::::::. . ::::::::::
NP_001 RQGCHQYVIHNNKCIPECPSGYTMN-SSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQE
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB9 LQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLIL
:.:::...:.:.:::: :::.:.::: .:::: ..::.:::.:.:::::::...::::
NP_001 LRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIR
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB9 GEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTK
:: ::::::.::::::.:::::...:::: ::..: .:::::.:::..::::.:::
NP_001 GETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTK
420 430 440 450 460 470
470 480 490 500 510 520
pF1KB9 GRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKE
::: ..:: ..::..::::...:.:. :: ..:.. :. : :::.:::..: ..:::
NP_001 GRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKE
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB9 APFKNVTEYDGQDACGSNSWNMVDVDLP-----PNKDVEPGILLHGLKPWTQYAVYVKAV
::..::::.:::::::::::..::.: : :... .:: :..:::::::::..::..
NP_001 APYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTL
540 550 560 570 580 590
590 600 610 620 630 640
pF1KB9 TLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYY
.:. .. . ::::.:.:..:.:. ::.::: .:.::::::.:.::.::: ::::...:
NP_001 -VTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHY
600 610 620 630 640 650
650 660 670 680 690 700
pF1KB9 IVRWQRQPQDGYLYRHNYCSKD-KIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACP
.: :.:: .:. :.. .:: : :.: : .. .. :. .. ..: . : ::.::
NP_001 LVFWERQAEDSELFELDYCLKGLKLPSRTWSP-PFESEDSQKHNQSEYEDSA-GECCSCP
660 670 680 690 700 710
710 720 730 740 750 760
pF1KB9 KTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAA--D
::... : ::. .::.::..::: .::::: ::::.. .:.:.:.. :.:: .
NP_001 KTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGDVGNVTVAV---PTVAAFPN
720 730 740 750 760 770
770 780 790 800 810 820
pF1KB9 TYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFV
: . . : : . :: .: ::: :::.:: :: :::....::... . ::.. .:
NP_001 TSSTSVPTSPEEHRPF--EKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV
780 790 800 810 820
830 840 850 860 870
pF1KB9 FARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEI---KYGSQVEDQRE
::::: :::: :::: : .: . : : ::..:::::..::. .::. :. .
NP_001 SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGD--EELHL
830 840 850 860 870 880
880 890 900 910 920 930
pF1KB9 CVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAK-RYENFIHLII
::::... : .: :.::::..::.::::.::::::.:..::: . : ::
NP_001 CVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKII
890 900 910 920 930 940
940 950 960 970 980 990
pF1KB9 ALPVAVLLIVGGLVIMLYVFHRKRN-NSRLGNGVLYASVNPEYFSAADV-----YVPDEW
:. ... . .. .:.: :::. .. :: :::: ::::.::.:: ::::::
NP_001 IGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGP--LYASSNPEYLSASDVFPCSVYVPDEW
950 960 970 980 990 1000
1000 1010 1020 1030 1040 1050
pF1KB9 EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEAS
::.:::::. :::::::::::::: :. ..: : :::::.:::::.::.:::::::::::
NP_001 EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEAS
1010 1020 1030 1040 1050 1060
1060 1070 1080 1090 1100 1110
pF1KB9 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKM
::: :.::::::::::::.::::::.::::..::::::::::::: :::: ::.:..:
NP_001 VMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEM
1070 1080 1090 1100 1110 1120
1120 1130 1140 1150 1160 1170
pF1KB9 IQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKG
::::.:::::::::::.:::::::::::::::.:::::::::::::::::::::::::::
NP_001 IQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKG
1130 1140 1150 1160 1170 1180
1180 1190 1200 1210 1220 1230
pF1KB9 LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLD
:::::::.::::::::::: ::.::::::::::..:::::::::::::::.:::.:: ::
NP_001 LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLD
1190 1200 1210 1220 1230 1240
1240 1250 1260 1270 1280 1290
pF1KB9 KPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEE
.:::::. . .:::::::.::::::.::::.. .:....:.: ::::..::::: :: ::
NP_001 QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEE
1250 1260 1270 1280 1290 1300
1300 1310 1320 1330 1340 1350
pF1KB9 LDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENG-PGPGVLVLRASFDERQPYAHMNG
:..: :.::.:::: :. : .. .: : . : .. :..:. ::.::::
NP_001 LEMEFEDMENVPLDRSS----------HCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNG
1310 1320 1330 1340 1350
1360
pF1KB9 GRKNERALPLPQSSTC
:.:: : : ::.:.
NP_001 GKKNGRILTLPRSNPS
1360 1370
1366 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 18:19:00 2016 done: Thu Nov 3 18:19:02 2016
Total Scan time: 11.410 Total Display time: 0.600
Function used was FASTA [36.3.4 Apr, 2011]