Result of FASTA (omim) for
pFN21AB5053
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5053, 780 aa
1>>>pF1KB5053 780 - 780 aa - 780 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6739+/-0.000435; mu= 18.5914+/- 0.027
mean_var=74.0253+/-15.048, 0's: 0 Z-trim(111.0): 68 B-trim: 632 in 1/52
Lambda= 0.149068
statistics sampled from 19424 (19463) to 19424 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.588), E-opt: 0.2 (0.228), width: 16
Scan time: 9.170
The best scores are: opt bits E(85289)
NP_001089 (OMIM: 100850,614559,616289) aconitate h ( 780) 5255 1140.2 0
XP_016884301 (OMIM: 100850,614559,616289) PREDICTE ( 747) 5047 1095.5 0
XP_005251533 (OMIM: 100880) PREDICTED: cytoplasmic ( 889) 352 85.8 8.9e-16
NP_002188 (OMIM: 100880) cytoplasmic aconitate hyd ( 889) 352 85.8 8.9e-16
NP_001265281 (OMIM: 100880) cytoplasmic aconitate ( 889) 352 85.8 8.9e-16
XP_011516190 (OMIM: 100880) PREDICTED: cytoplasmic ( 889) 352 85.8 8.9e-16
NP_001307870 (OMIM: 147582) iron-responsive elemen ( 713) 325 79.9 4.1e-14
NP_001307871 (OMIM: 147582) iron-responsive elemen ( 906) 325 80.0 5e-14
NP_004127 (OMIM: 147582) iron-responsive element-b ( 963) 325 80.0 5.3e-14
NP_001307872 (OMIM: 147582) iron-responsive elemen ( 343) 170 46.4 0.00024
>>NP_001089 (OMIM: 100850,614559,616289) aconitate hydra (780 aa)
initn: 5255 init1: 5255 opt: 5255 Z-score: 6103.8 bits: 1140.2 E(85289): 0
Smith-Waterman score: 5255; 100.0% identity (100.0% similar) in 780 aa overlap (1-780:1-780)
10 20 30 40 50 60
pF1KB5 MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 PSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILEN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 YAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 WSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 HRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 VAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 EQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 DANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 QDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 GPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 GDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 VDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
730 740 750 760 770 780
>>XP_016884301 (OMIM: 100850,614559,616289) PREDICTED: a (747 aa)
initn: 5047 init1: 5047 opt: 5047 Z-score: 5862.3 bits: 1095.5 E(85289): 0
Smith-Waterman score: 5047; 100.0% identity (100.0% similar) in 747 aa overlap (34-780:1-747)
10 20 30 40 50 60
pF1KB5 YSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPL
::::::::::::::::::::::::::::::
XP_016 MSHFEPNEYIHYDLLEKNINIVRKRLNRPL
10 20 30
70 80 90 100 110 120
pF1KB5 TLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPST
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB5 IHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAY
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB5 PGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB5 PKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRM
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB5 KKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAE
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB5 VGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQI
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB5 RATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDAN
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB5 PETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDT
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB5 YQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPW
520 530 540 550 560 570
610 620 630 640 650 660
pF1KB5 LKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDE
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB5 NYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDK
640 650 660 670 680 690
730 740 750 760 770 780
pF1KB5 LTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
700 710 720 730 740
>>XP_005251533 (OMIM: 100880) PREDICTED: cytoplasmic aco (889 aa)
initn: 689 init1: 303 opt: 352 Z-score: 404.3 bits: 85.8 E(85289): 8.9e-16
Smith-Waterman score: 737; 28.5% identity (54.4% similar) in 744 aa overlap (91-709:78-818)
70 80 90 100 110
pF1KB5 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQF--ISSGLSKV
..: :: .:: :. :...: . ....:.
XP_005 RNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKL
50 60 70 80 90 100
120 130 140 150 160
pF1KB5 A---------VPSTIHCDHLIEAQVGGEKD-LRRAKDI----NQEVYNFLATAG-AKYGV
. :. . :: :... . . : :.. .:. :.: ..:: .. : ...
XP_005 GGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNM
110 120 130 140 150 160
170 180 190 200 210
pF1KB5 GFWKPGSGIIHQIILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADA
. ::::::::. :: .: :: : .:::::: ::: . :::: .:
XP_005 RIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSL-VGTDSHTTMIDGLGILGWGVGGIEA
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB5 VDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVD
:: : : . :.::: .: :. . :..: .. : : .: .::. ::::
XP_005 EAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVA
230 240 250 260 270 280
280 290 300 310 320
pF1KB5 SISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRED--------IANLADEFKDH
..: . ::: :: : :::.. :: .. :: .:::.. . . :.:
XP_005 QLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDF
290 300 310 320 330 340
330 340 350 360 370
pF1KB5 LVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGK-----VAEKEGW------P
:. . :..:..:. . : .:: :. :... : .. :.:. :
XP_005 NDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAP
350 360 370 380 390 400
380 390 400 410
pF1KB5 ----------LD----------IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKS-
: . .. : ::::.: .. .:.. ::.:. ::.
XP_005 EHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPY
410 420 430 440 450 460
420 430 440 450 460
pF1KB5 -QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDR------KDIKKGEK
. ...::: . ....: : .:: :.. .: :::. . : .:.
XP_005 IKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDL
470 480 490 500 510 520
470 480 490 500 510 520
pF1KB5 NTI-VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYL-TGTDGKKF
.. : : :::: :: ..:.:.: ...:: .: : :::::.... : . : ... :..
XP_005 VAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQV
530 540 550 560 570 580
530 540 550 560
pF1KB5 RLEA--PDADELPKGEFD---PG--QDTYQHPPKDSSGQHVDVSPT-------SQRLQLL
:. : ::. : . :: ...::. . . .. ..:. :. .
XP_005 FLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIK
590 600 610 620 630 640
570 580 590 600
pF1KB5 EP-------FDKWDGKDLEDLQILIKVKGKCTTDHISAAG------PWLKF---RG----
: .: :.. : .:... . :::::: :: : .. ::
XP_005 SPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPR
650 660 670 680 690 700
610 620 630 640 650
pF1KB5 HLDNISNNLLIGAI-------NIE------NGKANSVRNAVTQEFGPVPDTARYYKKHGI
.... .. :. ::. : .: .. . . :. : :.:. :.. :.
XP_005 EFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGL
710 720 730 740 750 760
660 670 680 690 700 710
pF1KB5 RWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADY
.:.. ..:: ::::. :: : :: .:....:. :::..:: .:..:: .
XP_005 PLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENA
770 780 790 800 810 820
720 730 740 750 760 770
pF1KB5 NKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRM
XP_005 DALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMI
830 840 850 860 870 880
>>NP_002188 (OMIM: 100880) cytoplasmic aconitate hydrata (889 aa)
initn: 689 init1: 303 opt: 352 Z-score: 404.3 bits: 85.8 E(85289): 8.9e-16
Smith-Waterman score: 737; 28.5% identity (54.4% similar) in 744 aa overlap (91-709:78-818)
70 80 90 100 110
pF1KB5 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQF--ISSGLSKV
..: :: .:: :. :...: . ....:.
NP_002 RNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKL
50 60 70 80 90 100
120 130 140 150 160
pF1KB5 A---------VPSTIHCDHLIEAQVGGEKD-LRRAKDI----NQEVYNFLATAG-AKYGV
. :. . :: :... . . : :.. .:. :.: ..:: .. : ...
NP_002 GGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNM
110 120 130 140 150 160
170 180 190 200 210
pF1KB5 GFWKPGSGIIHQIILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADA
. ::::::::. :: .: :: : .:::::: ::: . :::: .:
NP_002 RIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSL-VGTDSHTTMIDGLGILGWGVGGIEA
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB5 VDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVD
:: : : . :.::: .: :. . :..: .. : : .: .::. ::::
NP_002 EAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVA
230 240 250 260 270 280
280 290 300 310 320
pF1KB5 SISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRED--------IANLADEFKDH
..: . ::: :: : :::.. :: .. :: .:::.. . . :.:
NP_002 QLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDF
290 300 310 320 330 340
330 340 350 360 370
pF1KB5 LVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGK-----VAEKEGW------P
:. . :..:..:. . : .:: :. :... : .. :.:. :
NP_002 NDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAP
350 360 370 380 390 400
380 390 400 410
pF1KB5 ----------LD----------IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKS-
: . .. : ::::.: .. .:.. ::.:. ::.
NP_002 EHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPY
410 420 430 440 450 460
420 430 440 450 460
pF1KB5 -QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDR------KDIKKGEK
. ...::: . ....: : .:: :.. .: :::. . : .:.
NP_002 IKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDL
470 480 490 500 510 520
470 480 490 500 510 520
pF1KB5 NTI-VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYL-TGTDGKKF
.. : : :::: :: ..:.:.: ...:: .: : :::::.... : . : ... :..
NP_002 VAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQV
530 540 550 560 570 580
530 540 550 560
pF1KB5 RLEA--PDADELPKGEFD---PG--QDTYQHPPKDSSGQHVDVSPT-------SQRLQLL
:. : ::. : . :: ...::. . . .. ..:. :. .
NP_002 FLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIK
590 600 610 620 630 640
570 580 590 600
pF1KB5 EP-------FDKWDGKDLEDLQILIKVKGKCTTDHISAAG------PWLKF---RG----
: .: :.. : .:... . :::::: :: : .. ::
NP_002 SPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPR
650 660 670 680 690 700
610 620 630 640 650
pF1KB5 HLDNISNNLLIGAI-------NIE------NGKANSVRNAVTQEFGPVPDTARYYKKHGI
.... .. :. ::. : .: .. . . :. : :.:. :.. :.
NP_002 EFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGL
710 720 730 740 750 760
660 670 680 690 700 710
pF1KB5 RWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADY
.:.. ..:: ::::. :: : :: .:....:. :::..:: .:..:: .
NP_002 PLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENA
770 780 790 800 810 820
720 730 740 750 760 770
pF1KB5 NKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRM
NP_002 DALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMI
830 840 850 860 870 880
>>NP_001265281 (OMIM: 100880) cytoplasmic aconitate hydr (889 aa)
initn: 689 init1: 303 opt: 352 Z-score: 404.3 bits: 85.8 E(85289): 8.9e-16
Smith-Waterman score: 737; 28.5% identity (54.4% similar) in 744 aa overlap (91-709:78-818)
70 80 90 100 110
pF1KB5 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQF--ISSGLSKV
..: :: .:: :. :...: . ....:.
NP_001 RNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKL
50 60 70 80 90 100
120 130 140 150 160
pF1KB5 A---------VPSTIHCDHLIEAQVGGEKD-LRRAKDI----NQEVYNFLATAG-AKYGV
. :. . :: :... . . : :.. .:. :.: ..:: .. : ...
NP_001 GGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNM
110 120 130 140 150 160
170 180 190 200 210
pF1KB5 GFWKPGSGIIHQIILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADA
. ::::::::. :: .: :: : .:::::: ::: . :::: .:
NP_001 RIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSL-VGTDSHTTMIDGLGILGWGVGGIEA
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB5 VDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVD
:: : : . :.::: .: :. . :..: .. : : .: .::. ::::
NP_001 EAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVA
230 240 250 260 270 280
280 290 300 310 320
pF1KB5 SISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRED--------IANLADEFKDH
..: . ::: :: : :::.. :: .. :: .:::.. . . :.:
NP_001 QLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDF
290 300 310 320 330 340
330 340 350 360 370
pF1KB5 LVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGK-----VAEKEGW------P
:. . :..:..:. . : .:: :. :... : .. :.:. :
NP_001 NDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAP
350 360 370 380 390 400
380 390 400 410
pF1KB5 ----------LD----------IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKS-
: . .. : ::::.: .. .:.. ::.:. ::.
NP_001 EHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPY
410 420 430 440 450 460
420 430 440 450 460
pF1KB5 -QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDR------KDIKKGEK
. ...::: . ....: : .:: :.. .: :::. . : .:.
NP_001 IKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDL
470 480 490 500 510 520
470 480 490 500 510 520
pF1KB5 NTI-VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYL-TGTDGKKF
.. : : :::: :: ..:.:.: ...:: .: : :::::.... : . : ... :..
NP_001 VAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQV
530 540 550 560 570 580
530 540 550 560
pF1KB5 RLEA--PDADELPKGEFD---PG--QDTYQHPPKDSSGQHVDVSPT-------SQRLQLL
:. : ::. : . :: ...::. . . .. ..:. :. .
NP_001 FLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIK
590 600 610 620 630 640
570 580 590 600
pF1KB5 EP-------FDKWDGKDLEDLQILIKVKGKCTTDHISAAG------PWLKF---RG----
: .: :.. : .:... . :::::: :: : .. ::
NP_001 SPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPR
650 660 670 680 690 700
610 620 630 640 650
pF1KB5 HLDNISNNLLIGAI-------NIE------NGKANSVRNAVTQEFGPVPDTARYYKKHGI
.... .. :. ::. : .: .. . . :. : :.:. :.. :.
NP_001 EFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGL
710 720 730 740 750 760
660 670 680 690 700 710
pF1KB5 RWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADY
.:.. ..:: ::::. :: : :: .:....:. :::..:: .:..:: .
NP_001 PLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENA
770 780 790 800 810 820
720 730 740 750 760 770
pF1KB5 NKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRM
NP_001 DALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMI
830 840 850 860 870 880
>>XP_011516190 (OMIM: 100880) PREDICTED: cytoplasmic aco (889 aa)
initn: 689 init1: 303 opt: 352 Z-score: 404.3 bits: 85.8 E(85289): 8.9e-16
Smith-Waterman score: 737; 28.5% identity (54.4% similar) in 744 aa overlap (91-709:78-818)
70 80 90 100 110
pF1KB5 RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQF--ISSGLSKV
..: :: .:: :. :...: . ....:.
XP_011 RNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKL
50 60 70 80 90 100
120 130 140 150 160
pF1KB5 A---------VPSTIHCDHLIEAQVGGEKD-LRRAKDI----NQEVYNFLATAG-AKYGV
. :. . :: :... . . : :.. .:. :.: ..:: .. : ...
XP_011 GGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNM
110 120 130 140 150 160
170 180 190 200 210
pF1KB5 GFWKPGSGIIHQIILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADA
. ::::::::. :: .: :: : .:::::: ::: . :::: .:
XP_011 RIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSL-VGTDSHTTMIDGLGILGWGVGGIEA
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB5 VDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVD
:: : : . :.::: .: :. . :..: .. : : .: .::. ::::
XP_011 EAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVA
230 240 250 260 270 280
280 290 300 310 320
pF1KB5 SISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRED--------IANLADEFKDH
..: . ::: :: : :::.. :: .. :: .:::.. . . :.:
XP_011 QLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDF
290 300 310 320 330 340
330 340 350 360 370
pF1KB5 LVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGK-----VAEKEGW------P
:. . :..:..:. . : .:: :. :... : .. :.:. :
XP_011 NDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAP
350 360 370 380 390 400
380 390 400 410
pF1KB5 ----------LD----------IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKS-
: . .. : ::::.: .. .:.. ::.:. ::.
XP_011 EHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPY
410 420 430 440 450 460
420 430 440 450 460
pF1KB5 -QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDR------KDIKKGEK
. ...::: . ....: : .:: :.. .: :::. . : .:.
XP_011 IKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDL
470 480 490 500 510 520
470 480 490 500 510 520
pF1KB5 NTI-VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYL-TGTDGKKF
.. : : :::: :: ..:.:.: ...:: .: : :::::.... : . : ... :..
XP_011 VAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQV
530 540 550 560 570 580
530 540 550 560
pF1KB5 RLEA--PDADELPKGEFD---PG--QDTYQHPPKDSSGQHVDVSPT-------SQRLQLL
:. : ::. : . :: ...::. . . .. ..:. :. .
XP_011 FLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIK
590 600 610 620 630 640
570 580 590 600
pF1KB5 EP-------FDKWDGKDLEDLQILIKVKGKCTTDHISAAG------PWLKF---RG----
: .: :.. : .:... . :::::: :: : .. ::
XP_011 SPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPR
650 660 670 680 690 700
610 620 630 640 650
pF1KB5 HLDNISNNLLIGAI-------NIE------NGKANSVRNAVTQEFGPVPDTARYYKKHGI
.... .. :. ::. : .: .. . . :. : :.:. :.. :.
XP_011 EFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGL
710 720 730 740 750 760
660 670 680 690 700 710
pF1KB5 RWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADY
.:.. ..:: ::::. :: : :: .:....:. :::..:: .:..:: .
XP_011 PLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENA
770 780 790 800 810 820
720 730 740 750 760 770
pF1KB5 NKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRM
XP_011 DALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMI
830 840 850 860 870 880
>>NP_001307870 (OMIM: 147582) iron-responsive element-bi (713 aa)
initn: 495 init1: 283 opt: 325 Z-score: 374.3 bits: 79.9 E(85289): 4.1e-14
Smith-Waterman score: 571; 28.2% identity (52.4% similar) in 639 aa overlap (173-709:10-643)
150 160 170 180 190 200
pF1KB5 AKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILE--NYAYPGVLLIGTDSHTPNGGG
. ....: . .: . .::::: .:
NP_001 MAHQINLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNG
10 20 30
210 220 230 240 250 260
pF1KB5 LGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGG
:: . :::: .. :: :.: : :.:.: .:::: . . . ::.: .. : :
NP_001 LGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGV
40 50 60 70 80 90
270 280 290 300 310
pF1KB5 TGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTG--------R
.: .::. : ::...: . .:: :: : :: : :: .. :.: .::
NP_001 AGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESM
100 110 120 130 140 150
320 330 340 350 360
pF1KB5 EDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTP-----------DLAHPV
: . . :.. . .:.:.:.:::. . : ..:: : :. .
NP_001 ETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACL
160 170 180 190 200 210
370 380 390 400
pF1KB5 AE-VG-----KVAEK---------EG--WPLD---IRVGLIGSCTNSSYEDMGRSAAV-A
: :: .::: :: . :. . .. . ::::. .. .:.. :
NP_001 NEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLA
220 230 240 250 260 270
410 420 430 440 450
pF1KB5 KQALAHGLKCKSQF--TITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQW-DR
:.:. ::. : . ...::: .. . .: : :: ... .:. :.:.
NP_001 KKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPL
280 290 300 310 320 330
460 470 480 490 500 510
pF1KB5 KD-----IKKGEKNTI-VTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPET
.: .:.:. : . : :.:: :: . ...:: .:.: :::::.... .:
NP_001 SDAVLNAVKQGDLVTCGILSGNKNFEGRL-CDCVRANYLASPPLVVAYAIAGTVNIDFQT
340 350 360 370 380 390
520 530 540 550
pF1KB5 DYLTGTD--GKKFRLEA--PDADELPKGE--------FDPGQDTYQHPPK--------DS
. : ::: ::.. :. :. .:. . : : .: . : ::
NP_001 EPL-GTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDS
400 410 420 430 440 450
560 570 580 590 600
pF1KB5 SGQHVDVSPTSQRLQLLEPFDKWDGKDL-----EDLQILIKVKGKCTTDHISAAGPWLKF
:.. : : . ::: . . :. ..:. . . :::::: :: .
NP_001 VLFPWDLKSTYIRCPSF--FDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARN
460 470 480 490 500 510
610 620 630 640
pF1KB5 RGHLDNISNNLL----IGAINIENGK-ANSVRN--AVTQEFG-----PVPDT--------
. ..: : ... . . :. : .:. : . :. :.: :
NP_001 SAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQT
520 530 540 550 560 570
650 660 670 680 690 700
pF1KB5 ------ARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLK
:. :.:.:: .... ..:: :.::. :: : :: .:....:. .::. .:
NP_001 LDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLI
580 590 600 610 620 630
710 720 730 740 750 760
pF1KB5 KQGLLPLTFADPADYNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNE
:. :: :
NP_001 GIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDV
640 650 660 670 680 690
>>NP_001307871 (OMIM: 147582) iron-responsive element-bi (906 aa)
initn: 571 init1: 283 opt: 325 Z-score: 372.7 bits: 80.0 E(85289): 5e-14
Smith-Waterman score: 600; 28.3% identity (52.1% similar) in 674 aa overlap (147-709:168-836)
120 130 140 150 160 170
pF1KB5 KVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKY-GVGFWKPGSGIIHQ
:.: .:. .. . .:. ::.:. ::
NP_001 ENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQ
140 150 160 170 180 190
180 190 200 210 220
pF1KB5 IILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELK
: :: . .: . .::::: .::: . :::: .. :: :.: :
NP_001 INLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLT
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB5 CPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICN
:.:.: .:::: . . . ::.: .. : : .: .::. : ::...: . .:: :
NP_001 LPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIAN
260 270 280 290 300 310
290 300 310 320 330
pF1KB5 MGAEIGATTSVFPYNHRMKKYLSKTG--------REDIANLADEFKDHLVPDPGCHYDQL
: : :: : :: .. :.: .:: : . . :.. . .:.:.
NP_001 MCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQV
320 330 340 350 360 370
340 350 360 370
pF1KB5 IEINLSELKPHINGPFTP-----------DLAHPVAE-VG-----KVAEK---------E
:.:::. . : ..:: : :. . : :: .::: :
NP_001 IQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYE
380 390 400 410 420 430
380 390 400 410 420
pF1KB5 G--WPLD---IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKSQF--TITPGSEQI
: . :. . .. . ::::. .. .:.. ::.:. ::. : . ...::: ..
NP_001 GSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMV
440 450 460 470 480 490
430 440 450 460 470
pF1KB5 RATIERDGYAQILRDLGGIVLANACGPCIGQW-DRKD-----IKKGEKNTI-VTSYNRNF
. .: : :: ... .:. :.:. .: .:.:. : . : :.::
NP_001 THYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNF
500 510 520 530 540 550
480 490 500 510 520 530
pF1KB5 TGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTD--GKKFRLEA--PDADEL
:: . ...:: .:.: :::::.... .:. : ::: ::.. :. :. .:.
NP_001 EGRL-CDCVRANYLASPPLVVAYAIAGTVNIDFQTEPL-GTDPTGKNIYLHDIWPSREEV
560 570 580 590 600 610
540 550 560 570
pF1KB5 PKGE--------FDPGQDTYQHPPK--------DSSGQHVDVSPTSQRLQLLEPFDKWDG
. : : .: . : :: :.. : : . :::
NP_001 HRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSF--FDKLTK
620 630 640 650 660 670
580 590 600 610 620
pF1KB5 KDL-----EDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLL----IGAINIENG
. . :. ..:. . . :::::: :: . . ..: : ... . . :
NP_001 EPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRG
680 690 700 710 720 730
630 640 650 660
pF1KB5 K-ANSVRN--AVTQEFG-----PVPDT--------------ARYYKKHGIRWVVIGDENY
. : .:. : . :. :.: : :. :.:.:: .... ..:
NP_001 NDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKY
740 750 760 770 780 790
670 680 690 700 710 720
pF1KB5 GEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLT
: :.::. :: : :: .:....:. .::. .: :. :: :
NP_001 GSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRET
800 810 820 830 840 850
730 740 750 760 770 780
pF1KB5 IQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
NP_001 FSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS
860 870 880 890 900
>>NP_004127 (OMIM: 147582) iron-responsive element-bindi (963 aa)
initn: 571 init1: 283 opt: 325 Z-score: 372.3 bits: 80.0 E(85289): 5.3e-14
Smith-Waterman score: 600; 28.3% identity (52.1% similar) in 674 aa overlap (147-709:225-893)
120 130 140 150 160 170
pF1KB5 KVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKY-GVGFWKPGSGIIHQ
:.: .:. .. . .:. ::.:. ::
NP_004 ENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQ
200 210 220 230 240 250
180 190 200 210 220
pF1KB5 IILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELK
: :: . .: . .::::: .::: . :::: .. :: :.: :
NP_004 INLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLT
260 270 280 290 300 310
230 240 250 260 270 280
pF1KB5 CPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICN
:.:.: .:::: . . . ::.: .. : : .: .::. : ::...: . .:: :
NP_004 LPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIAN
320 330 340 350 360 370
290 300 310 320 330
pF1KB5 MGAEIGATTSVFPYNHRMKKYLSKTG--------REDIANLADEFKDHLVPDPGCHYDQL
: : :: : :: .. :.: .:: : . . :.. . .:.:.
NP_004 MCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQV
380 390 400 410 420 430
340 350 360 370
pF1KB5 IEINLSELKPHINGPFTP-----------DLAHPVAE-VG-----KVAEK---------E
:.:::. . : ..:: : :. . : :: .::: :
NP_004 IQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYE
440 450 460 470 480 490
380 390 400 410 420
pF1KB5 G--WPLD---IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKSQF--TITPGSEQI
: . :. . .. . ::::. .. .:.. ::.:. ::. : . ...::: ..
NP_004 GSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMV
500 510 520 530 540 550
430 440 450 460 470
pF1KB5 RATIERDGYAQILRDLGGIVLANACGPCIGQW-DRKD-----IKKGEKNTI-VTSYNRNF
. .: : :: ... .:. :.:. .: .:.:. : . : :.::
NP_004 THYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNF
560 570 580 590 600 610
480 490 500 510 520 530
pF1KB5 TGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTD--GKKFRLEA--PDADEL
:: . ...:: .:.: :::::.... .:. : ::: ::.. :. :. .:.
NP_004 EGRL-CDCVRANYLASPPLVVAYAIAGTVNIDFQTEPL-GTDPTGKNIYLHDIWPSREEV
620 630 640 650 660 670
540 550 560 570
pF1KB5 PKGE--------FDPGQDTYQHPPK--------DSSGQHVDVSPTSQRLQLLEPFDKWDG
. : : .: . : :: :.. : : . :::
NP_004 HRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSF--FDKLTK
680 690 700 710 720
580 590 600 610 620
pF1KB5 KDL-----EDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLL----IGAINIENG
. . :. ..:. . . :::::: :: . . ..: : ... . . :
NP_004 EPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRG
730 740 750 760 770 780
630 640 650 660
pF1KB5 K-ANSVRN--AVTQEFG-----PVPDT--------------ARYYKKHGIRWVVIGDENY
. : .:. : . :. :.: : :. :.:.:: .... ..:
NP_004 NDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKY
790 800 810 820 830 840
670 680 690 700 710 720
pF1KB5 GEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLT
: :.::. :: : :: .:....:. .::. .: :. :: :
NP_004 GSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRET
850 860 870 880 890 900
730 740 750 760 770 780
pF1KB5 IQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
NP_004 FSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS
910 920 930 940 950 960
>>NP_001307872 (OMIM: 147582) iron-responsive element-bi (343 aa)
initn: 240 init1: 164 opt: 170 Z-score: 199.0 bits: 46.4 E(85289): 0.00024
Smith-Waterman score: 199; 33.6% identity (58.0% similar) in 119 aa overlap (147-254:225-342)
120 130 140 150 160 170
pF1KB5 KVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKY-GVGFWKPGSGIIHQ
:.: .:. .. . .:. ::.:. ::
NP_001 ENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQ
200 210 220 230 240 250
180 190 200 210 220
pF1KB5 IILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELK
: :: . .: . .::::: .::: . :::: .. :: :.: :
NP_001 INLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLT
260 270 280 290 300 310
230 240 250 260 270 280
pF1KB5 CPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICN
:.:.: .:::: . . . ::.: .. .
NP_001 LPEVVGCELTGSSNPFVTSIDVVLGITKVS
320 330 340
780 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 15:50:10 2016 done: Thu Nov 3 15:50:12 2016
Total Scan time: 9.170 Total Display time: 0.190
Function used was FASTA [36.3.4 Apr, 2011]