Result of FASTA (omim) for
pFN21AB4573
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4573, 648 aa
1>>>pF1KB4573 648 - 648 aa - 648 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.9707+/-0.000656; mu= 0.4953+/- 0.040
mean_var=774.3879+/-177.500, 0's: 0 Z-trim(116.0): 1475 B-trim: 0 in 0/56
Lambda= 0.046089
statistics sampled from 24804 (26793) to 24804 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.655), E-opt: 0.2 (0.314), width: 16
Scan time: 11.080
The best scores are: opt bits E(85289)
XP_011532276 (OMIM: 164760,611553,611554,615916) P ( 648) 4370 307.4 1e-82
XP_005265412 (OMIM: 164760,611553,611554,615916) P ( 648) 4370 307.4 1e-82
NP_002871 (OMIM: 164760,611553,611554,615916) RAF ( 648) 4370 307.4 1e-82
XP_011532277 (OMIM: 164760,611553,611554,615916) P ( 567) 3634 258.4 5.2e-68
XP_005265415 (OMIM: 164760,611553,611554,615916) P ( 567) 3634 258.4 5.2e-68
XP_005265416 (OMIM: 164760,611553,611554,615916) P ( 534) 2800 202.9 2.5e-51
XP_005265414 (OMIM: 164760,611553,611554,615916) P ( 615) 2800 203.0 2.7e-51
XP_016862455 (OMIM: 164760,611553,611554,615916) P ( 615) 2800 203.0 2.7e-51
NP_001645 (OMIM: 311010) serine/threonine-protein ( 606) 2457 180.2 1.9e-44
XP_011542210 (OMIM: 311010) PREDICTED: serine/thre ( 606) 2457 180.2 1.9e-44
XP_006724592 (OMIM: 311010) PREDICTED: serine/thre ( 611) 2451 179.8 2.6e-44
XP_011542208 (OMIM: 311010) PREDICTED: serine/thre ( 611) 2451 179.8 2.6e-44
NP_001243125 (OMIM: 311010) serine/threonine-prote ( 609) 2449 179.6 2.8e-44
NP_004324 (OMIM: 115150,163950,164757,211980,61370 ( 766) 1797 136.5 3.5e-31
XP_005250102 (OMIM: 115150,163950,164757,211980,61 ( 767) 1797 136.5 3.5e-31
XP_011542211 (OMIM: 311010) PREDICTED: serine/thre ( 387) 1744 132.4 2.9e-30
XP_016868047 (OMIM: 115150,163950,164757,211980,61 ( 807) 1738 132.6 5.4e-30
XP_016868048 (OMIM: 115150,163950,164757,211980,61 ( 798) 1581 122.1 7.5e-27
NP_001243126 (OMIM: 311010) serine/threonine-prote ( 186) 645 58.8 2.1e-08
XP_016866143 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 535 52.3 5.4e-06
XP_016866139 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 535 52.3 5.4e-06
XP_016866140 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 535 52.3 5.4e-06
XP_016866142 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 535 52.3 5.4e-06
XP_016866141 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 535 52.3 5.4e-06
NP_002028 (OMIM: 137025) tyrosine-protein kinase F ( 537) 535 52.3 5.4e-06
XP_016881449 (OMIM: 164880) PREDICTED: tyrosine-pr ( 543) 527 51.8 7.9e-06
NP_005424 (OMIM: 164880) tyrosine-protein kinase Y ( 543) 527 51.8 7.9e-06
XP_011527315 (OMIM: 114500,190090,616937) PREDICTE ( 536) 523 51.5 9.4e-06
NP_005408 (OMIM: 114500,190090,616937) proto-oncog ( 536) 523 51.5 9.4e-06
NP_938033 (OMIM: 114500,190090,616937) proto-oncog ( 536) 523 51.5 9.4e-06
XP_016883516 (OMIM: 114500,190090,616937) PREDICTE ( 542) 523 51.5 9.4e-06
XP_016883513 (OMIM: 114500,190090,616937) PREDICTE ( 542) 523 51.5 9.4e-06
XP_016883515 (OMIM: 114500,190090,616937) PREDICTE ( 542) 523 51.5 9.4e-06
XP_016883514 (OMIM: 114500,190090,616937) PREDICTE ( 542) 523 51.5 9.4e-06
XP_011533958 (OMIM: 606573) PREDICTED: tyrosine-pr ( 392) 517 50.8 1.1e-05
XP_005266947 (OMIM: 137025) PREDICTED: tyrosine-pr ( 534) 519 51.2 1.1e-05
NP_694592 (OMIM: 137025) tyrosine-protein kinase F ( 534) 519 51.2 1.1e-05
XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 517 51.0 1.2e-05
XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 517 51.0 1.2e-05
XP_005266939 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 517 51.0 1.2e-05
NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 517 51.0 1.2e-05
XP_011533955 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 517 51.0 1.2e-05
XP_011533957 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 517 51.0 1.2e-05
XP_016866134 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 517 51.0 1.2e-05
XP_005266938 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 517 51.0 1.2e-05
XP_016874699 (OMIM: 610737) PREDICTED: kinase supp ( 515) 511 50.7 1.6e-05
XP_011536530 (OMIM: 610737) PREDICTED: kinase supp ( 647) 511 50.8 1.8e-05
XP_011536527 (OMIM: 610737) PREDICTED: kinase supp ( 829) 511 51.0 2e-05
NP_775869 (OMIM: 610737) kinase suppressor of Ras ( 921) 511 51.1 2.1e-05
XP_011536526 (OMIM: 610737) PREDICTED: kinase supp ( 948) 511 51.1 2.1e-05
>>XP_011532276 (OMIM: 164760,611553,611554,615916) PREDI (648 aa)
initn: 4370 init1: 4370 opt: 4370 Z-score: 1606.0 bits: 307.4 E(85289): 1e-82
Smith-Waterman score: 4370; 100.0% identity (100.0% similar) in 648 aa overlap (1-648:1-648)
10 20 30 40 50 60
pF1KB4 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
550 560 570 580 590 600
610 620 630 640
pF1KB4 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
610 620 630 640
>>XP_005265412 (OMIM: 164760,611553,611554,615916) PREDI (648 aa)
initn: 4370 init1: 4370 opt: 4370 Z-score: 1606.0 bits: 307.4 E(85289): 1e-82
Smith-Waterman score: 4370; 100.0% identity (100.0% similar) in 648 aa overlap (1-648:1-648)
10 20 30 40 50 60
pF1KB4 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
550 560 570 580 590 600
610 620 630 640
pF1KB4 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
610 620 630 640
>>NP_002871 (OMIM: 164760,611553,611554,615916) RAF prot (648 aa)
initn: 4370 init1: 4370 opt: 4370 Z-score: 1606.0 bits: 307.4 E(85289): 1e-82
Smith-Waterman score: 4370; 100.0% identity (100.0% similar) in 648 aa overlap (1-648:1-648)
10 20 30 40 50 60
pF1KB4 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
550 560 570 580 590 600
610 620 630 640
pF1KB4 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
610 620 630 640
>>XP_011532277 (OMIM: 164760,611553,611554,615916) PREDI (567 aa)
initn: 3634 init1: 3634 opt: 3634 Z-score: 1342.0 bits: 258.4 E(85289): 5.2e-68
Smith-Waterman score: 3634; 100.0% identity (100.0% similar) in 541 aa overlap (108-648:27-567)
80 90 100 110 120 130
pF1KB4 LHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLT
::::::::::::::::::::::::::::::
XP_011 MMANSQILLRQATLSVFSCRTSKEQCKKARLDWNTDAASLIGEELQVDFLDHVPLT
10 20 30 40 50
140 150 160 170 180 190
pF1KB4 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFP
60 70 80 90 100 110
200 210 220 230 240 250
pF1KB4 NSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
120 130 140 150 160 170
260 270 280 290 300 310
pF1KB4 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
180 190 200 210 220 230
320 330 340 350 360 370
pF1KB4 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
240 250 260 270 280 290
380 390 400 410 420 430
pF1KB4 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
300 310 320 330 340 350
440 450 460 470 480 490
pF1KB4 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
360 370 380 390 400 410
500 510 520 530 540 550
pF1KB4 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
420 430 440 450 460 470
560 570 580 590 600 610
pF1KB4 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
480 490 500 510 520 530
620 630 640
pF1KB4 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
:::::::::::::::::::::::::::::::
XP_011 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
540 550 560
>>XP_005265415 (OMIM: 164760,611553,611554,615916) PREDI (567 aa)
initn: 3634 init1: 3634 opt: 3634 Z-score: 1342.0 bits: 258.4 E(85289): 5.2e-68
Smith-Waterman score: 3634; 100.0% identity (100.0% similar) in 541 aa overlap (108-648:27-567)
80 90 100 110 120 130
pF1KB4 LHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLT
::::::::::::::::::::::::::::::
XP_005 MMANSQILLRQATLSVFSCRTSKEQCKKARLDWNTDAASLIGEELQVDFLDHVPLT
10 20 30 40 50
140 150 160 170 180 190
pF1KB4 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFP
60 70 80 90 100 110
200 210 220 230 240 250
pF1KB4 NSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
120 130 140 150 160 170
260 270 280 290 300 310
pF1KB4 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
180 190 200 210 220 230
320 330 340 350 360 370
pF1KB4 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
240 250 260 270 280 290
380 390 400 410 420 430
pF1KB4 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
300 310 320 330 340 350
440 450 460 470 480 490
pF1KB4 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
360 370 380 390 400 410
500 510 520 530 540 550
pF1KB4 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
420 430 440 450 460 470
560 570 580 590 600 610
pF1KB4 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
480 490 500 510 520 530
620 630 640
pF1KB4 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
:::::::::::::::::::::::::::::::
XP_005 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
540 550 560
>>XP_005265416 (OMIM: 164760,611553,611554,615916) PREDI (534 aa)
initn: 3402 init1: 2800 opt: 2800 Z-score: 1042.5 bits: 202.9 E(85289): 2.5e-51
Smith-Waterman score: 3340; 93.7% identity (93.9% similar) in 541 aa overlap (108-648:27-534)
80 90 100 110 120 130
pF1KB4 LHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLT
::::::::::::::::::::::::::::::
XP_005 MMANSQILLRQATLSVFSCRTSKEQCKKARLDWNTDAASLIGEELQVDFLDHVPLT
10 20 30 40 50
140 150 160 170 180 190
pF1KB4 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_005 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLF---
60 70 80 90 100 110
200 210 220 230 240 250
pF1KB4 NSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
::::::::::::::::::::::::::::::
XP_005 ------------------------------SQHRYSTPHAFTFNTSSPSSEGSLSQRQRS
120 130 140
260 270 280 290 300 310
pF1KB4 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRE
150 160 170 180 190 200
320 330 340 350 360 370
pF1KB4 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKIL
210 220 230 240 250 260
380 390 400 410 420 430
pF1KB4 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE
270 280 290 300 310 320
440 450 460 470 480 490
pF1KB4 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS
330 340 350 360 370 380
500 510 520 530 540 550
pF1KB4 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI
390 400 410 420 430 440
560 570 580 590 600 610
pF1KB4 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKIN
450 460 470 480 490 500
620 630 640
pF1KB4 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
:::::::::::::::::::::::::::::::
XP_005 RSASEPSLHRAAHTEDINACTLTTSPRLPVF
510 520 530
>>XP_005265414 (OMIM: 164760,611553,611554,615916) PREDI (615 aa)
initn: 4138 init1: 2800 opt: 2800 Z-score: 1042.0 bits: 203.0 E(85289): 2.7e-51
Smith-Waterman score: 4076; 94.8% identity (94.9% similar) in 648 aa overlap (1-648:1-615)
10 20 30 40 50 60
pF1KB4 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
:::::::::::::. :::::::::::::
XP_005 PTMCVDWSNIRQLF---------------------------------SQHRYSTPHAFTF
190 200
250 260 270 280 290 300
pF1KB4 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
210 220 230 240 250 260
310 320 330 340 350 360
pF1KB4 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
270 280 290 300 310 320
370 380 390 400 410 420
pF1KB4 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
330 340 350 360 370 380
430 440 450 460 470 480
pF1KB4 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
390 400 410 420 430 440
490 500 510 520 530 540
pF1KB4 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
450 460 470 480 490 500
550 560 570 580 590 600
pF1KB4 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
510 520 530 540 550 560
610 620 630 640
pF1KB4 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
570 580 590 600 610
>>XP_016862455 (OMIM: 164760,611553,611554,615916) PREDI (615 aa)
initn: 4138 init1: 2800 opt: 2800 Z-score: 1042.0 bits: 203.0 E(85289): 2.7e-51
Smith-Waterman score: 4076; 94.8% identity (94.9% similar) in 648 aa overlap (1-648:1-615)
10 20 30 40 50 60
pF1KB4 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
:::::::::::::. :::::::::::::
XP_016 PTMCVDWSNIRQLF---------------------------------SQHRYSTPHAFTF
190 200
250 260 270 280 290 300
pF1KB4 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
210 220 230 240 250 260
310 320 330 340 350 360
pF1KB4 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
270 280 290 300 310 320
370 380 390 400 410 420
pF1KB4 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
330 340 350 360 370 380
430 440 450 460 470 480
pF1KB4 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
390 400 410 420 430 440
490 500 510 520 530 540
pF1KB4 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
450 460 470 480 490 500
550 560 570 580 590 600
pF1KB4 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
510 520 530 540 550 560
610 620 630 640
pF1KB4 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
570 580 590 600 610
>>NP_001645 (OMIM: 311010) serine/threonine-protein kina (606 aa)
initn: 2208 init1: 1617 opt: 2457 Z-score: 918.8 bits: 180.2 E(85289): 1.9e-44
Smith-Waterman score: 2457; 62.1% identity (81.1% similar) in 607 aa overlap (50-646:13-606)
20 30 40 50 60 70
pF1KB4 AVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLH
.::.. .:..:.:::::::::.::.:::..
NP_001 MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVY
10 20 30 40
80 90 100 110 120 130
pF1KB4 DCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTH
: : ::::::::. .::.:.::. ::.:. :.: : : :::: :. :. :::: :
NP_001 DSLDKALKVRGLNQDCCVVYRLI---KGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMH
50 60 70 80 90
140 150 160 170 180 190
pF1KB4 NFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNS
::.::::..:::::.: :::..::::::::::::.:::.::::.::: :. :: . .
NP_001 NFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQ
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB4 TI-GDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRST
. : : :: : . : .. . : . .. :. : : :. .. :: :::
NP_001 DLSGGSRQHEAPS--NRPLNELLTPQGPSPRTQHCDPEHFPF----PAPANAPLQRIRST
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB4 STPNVHMVSTTLPVDSRMIE--------DAIRSHSESASPSALSSSPNNLSPTGWSQPKT
::::::::::: :.:: .:. :: :.. : . : :: ..: .: ..:..
NP_001 STPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVS-SGRKSPHS
220 230 240 250 260 270
320 330 340 350 360
pF1KB4 PVPA-QRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWH
:: :::: : ...:.:.. : :::.::::. :::.: :::.::::::..:.::
NP_001 KSPAEQRERK--SLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWH
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB4 GDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSL
::::::.::: .:: :: :::.::. :::::::::::::::.::. ..::.:::::::::
NP_001 GDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSL
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB4 YKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGL
:.:::: .:.:.: ::::.::::::::::::::::::::.::::::::::::::::::::
NP_001 YHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGL
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB4 ATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYS
::::.::::.: .:::.::::::: ::::::: ::.:::::::.::.:::::::: ::::
NP_001 ATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYS
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB4 HINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELL
::. :::::::::::: ::::::. .::::::.::..::.: .::::::::::..::::
NP_001 HIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELL
520 530 540 550 560 570
610 620 630 640
pF1KB4 QHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
:.:::::.::::::::::. ..... :: :... .:
NP_001 QRSLPKIERSASEPSLHRT-QADELPACLLSAARLVP
580 590 600
>>XP_011542210 (OMIM: 311010) PREDICTED: serine/threonin (606 aa)
initn: 2208 init1: 1617 opt: 2457 Z-score: 918.8 bits: 180.2 E(85289): 1.9e-44
Smith-Waterman score: 2457; 62.1% identity (81.1% similar) in 607 aa overlap (50-646:13-606)
20 30 40 50 60 70
pF1KB4 AVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLH
.::.. .:..:.:::::::::.::.:::..
XP_011 MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVY
10 20 30 40
80 90 100 110 120 130
pF1KB4 DCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTH
: : ::::::::. .::.:.::. ::.:. :.: : : :::: :. :. :::: :
XP_011 DSLDKALKVRGLNQDCCVVYRLI---KGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMH
50 60 70 80 90
140 150 160 170 180 190
pF1KB4 NFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNS
::.::::..:::::.: :::..::::::::::::.:::.::::.::: :. :: . .
XP_011 NFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQ
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB4 TI-GDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRST
. : : :: : . : .. . : . .. :. : : :. .. :: :::
XP_011 DLSGGSRQHEAPS--NRPLNELLTPQGPSPRTQHCDPEHFPF----PAPANAPLQRIRST
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB4 STPNVHMVSTTLPVDSRMIE--------DAIRSHSESASPSALSSSPNNLSPTGWSQPKT
::::::::::: :.:: .:. :: :.. : . : :: ..: .: ..:..
XP_011 STPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVS-SGRKSPHS
220 230 240 250 260 270
320 330 340 350 360
pF1KB4 PVPA-QRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWH
:: :::: : ...:.:.. : :::.::::. :::.: :::.::::::..:.::
XP_011 KSPAEQRERK--SLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWH
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB4 GDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSL
::::::.::: .:: :: :::.::. :::::::::::::::.::. ..::.:::::::::
XP_011 GDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSL
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB4 YKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGL
:.:::: .:.:.: ::::.::::::::::::::::::::.::::::::::::::::::::
XP_011 YHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGL
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB4 ATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYS
::::.::::.: .:::.::::::: ::::::: ::.:::::::.::.:::::::: ::::
XP_011 ATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYS
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB4 HINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELL
::. :::::::::::: ::::::. .::::::.::..::.: .::::::::::..::::
XP_011 HIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELL
520 530 540 550 560 570
610 620 630 640
pF1KB4 QHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
:.:::::.::::::::::. ..... :: :... .:
XP_011 QRSLPKIERSASEPSLHRT-QADELPACLLSAARLVP
580 590 600
648 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 15:10:26 2016 done: Thu Nov 3 15:10:27 2016
Total Scan time: 11.080 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]