Result of FASTA (omim) for
pFN21AB4523
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4523, 505 aa
1>>>pF1KB4523 505 - 505 aa - 505 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.8983+/-0.000634; mu= -8.2860+/- 0.037
mean_var=843.1555+/-196.819, 0's: 0 Z-trim(114.0): 149 B-trim: 0 in 0/56
Lambda= 0.044169
statistics sampled from 23490 (23613) to 23490 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.277), width: 16
Scan time: 9.460
The best scores are: opt bits E(85289)
NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 3453 236.9 1.1e-61
NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 3098 214.2 6.5e-55
XP_016875690 (OMIM: 601300) PREDICTED: activin rec ( 381) 2579 181.0 5.4e-45
NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 2327 165.1 4.2e-40
NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 2314 164.3 7.5e-40
XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2210 157.6 6.9e-38
XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2210 157.6 6.9e-38
XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 2197 156.7 1.2e-37
NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 2157 154.3 7.6e-37
NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 2056 147.8 6.3e-35
XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 1907 138.1 4.1e-32
NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 1907 138.2 4.4e-32
XP_011537269 (OMIM: 601300) PREDICTED: activin rec ( 312) 1866 135.4 2.3e-31
XP_011537268 (OMIM: 601300) PREDICTED: activin rec ( 422) 1866 135.6 2.7e-31
NP_064733 (OMIM: 601300) activin receptor type-1B ( 546) 1866 135.8 3.1e-31
NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 1764 129.1 2.4e-29
XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 1616 119.8 1.8e-26
NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 1616 119.8 1.8e-26
NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 1616 119.8 1.8e-26
NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 1616 119.8 1.8e-26
XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 1616 119.8 1.8e-26
XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 1616 119.8 1.8e-26
XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 1616 119.8 1.8e-26
XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 1616 119.8 1.8e-26
NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 1616 119.9 1.9e-26
XP_016875689 (OMIM: 601300) PREDICTED: activin rec ( 494) 1589 118.1 6e-26
XP_016875688 (OMIM: 601300) PREDICTED: activin rec ( 494) 1589 118.1 6e-26
XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1564 116.6 1.9e-25
XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1564 116.6 1.9e-25
NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 1564 116.6 1.9e-25
XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 1519 113.7 1.3e-24
XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 1519 113.7 1.3e-24
XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1519 113.7 1.3e-24
NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 1437 108.4 5e-23
XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 1437 108.4 5e-23
NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 1437 108.4 5e-23
NP_001104503 (OMIM: 608981) activin receptor type- ( 336) 1289 98.7 2.8e-20
XP_011537310 (OMIM: 600376,601284) PREDICTED: seri ( 413) 1213 94.0 9e-19
XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532) 789 67.2 1.4e-10
XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532) 789 67.2 1.4e-10
NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567) 789 67.2 1.4e-10
XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576) 789 67.2 1.4e-10
NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592) 789 67.2 1.5e-10
NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 763 65.3 3.8e-10
NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 763 65.5 4.3e-10
>>NP_004293 (OMIM: 601300) activin receptor type-1B isof (505 aa)
initn: 3453 init1: 3453 opt: 3453 Z-score: 1228.7 bits: 236.9 E(85289): 1.1e-61
Smith-Waterman score: 3453; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505)
10 20 30 40 50 60
pF1KB4 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
430 440 450 460 470 480
490 500
pF1KB4 GAARLTALRIKKTLSQLSVQEDVKI
:::::::::::::::::::::::::
NP_004 GAARLTALRIKKTLSQLSVQEDVKI
490 500
>>NP_064732 (OMIM: 601300) activin receptor type-1B isof (453 aa)
initn: 3098 init1: 3098 opt: 3098 Z-score: 1106.8 bits: 214.2 E(85289): 6.5e-55
Smith-Waterman score: 3098; 100.0% identity (100.0% similar) in 453 aa overlap (53-505:1-453)
30 40 50 60 70 80
pF1KB4 GSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPF
::::::::::::::::::::::::::::::
NP_064 MVSIFNLDGMEHHVRTCIPKVELVPAGKPF
10 20 30
90 100 110 120 130 140
pF1KB4 YCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 YCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLII
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB4 IIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 IIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRT
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB4 VARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 VARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENIL
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB4 GFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 GFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEI
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB4 VGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 VGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMA
280 290 300 310 320 330
390 400 410 420 430 440
pF1KB4 PEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 PEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEE
340 350 360 370 380 390
450 460 470 480 490 500
pF1KB4 MRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 MRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQED
400 410 420 430 440 450
pF1KB4 VKI
:::
NP_064 VKI
>>XP_016875690 (OMIM: 601300) PREDICTED: activin recepto (381 aa)
initn: 2579 init1: 2579 opt: 2579 Z-score: 928.7 bits: 181.0 E(85289): 5.4e-45
Smith-Waterman score: 2579; 100.0% identity (100.0% similar) in 379 aa overlap (1-379:1-379)
10 20 30 40 50 60
pF1KB4 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
:::::::::::::::::::
XP_016 DAVTDTIDIAPNQRVGTKRSP
370 380
>>NP_001293139 (OMIM: 132800,190181) TGF-beta receptor t (507 aa)
initn: 2247 init1: 2130 opt: 2327 Z-score: 840.9 bits: 165.1 E(85289): 4.2e-40
Smith-Waterman score: 2327; 69.3% identity (84.3% similar) in 511 aa overlap (3-505:2-507)
10 20 30 40 50
pF1KB4 MAESAGASSFFPLVVLLLAGSGGSGPR---GVQALLCACTSCLQANYTCETDGACMVSIF
:.: :. :..:.::...... :. :: : : : . :.:: ::: :.::.
NP_001 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT
10 20 30 40 50
60 70 80 90 100 110
pF1KB4 NLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHCCYTDYCNRIDLRVPSGHLK
. : :: ...:.: .:: : : .. .:.:: :.::.:.: . .: ..
NP_001 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPT-TGPFS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB4 EPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-VYHNRQRLDMEDPSCEM-C
:.. :::::...::::: :. : ....: :.: : :.: . :::: .
NP_001 VKSSPGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRTVIHHRVP-NEEDPSLDRPF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB4 LSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVA
.:. ::.::.::..::::::::::.::::.:::::::: ::::::::::::.::: .::
NP_001 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB4 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB4 YLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIA
::::::::.:::::::::.::::::::::::::::::.::::::::::::::::: : ::
NP_001 YLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB4 DLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWE
:::::::::..:::::::::.::::::::::::::..::::::.::: :::::.:::.::
NP_001 DLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWE
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB4 IARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKM
:::::. ::.::.::::::::::::::.::::::::.::::::::: ::: ::::::.:.
NP_001 IARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKI
420 430 440 450 460 470
480 490 500
pF1KB4 MRECWYANGAARLTALRIKKTLSQLSVQEDVKI
:::::::::::::::::::::::::: :: .:.
NP_001 MRECWYANGAARLTALRIKKTLSQLSQQEGIKM
480 490 500
>>NP_004603 (OMIM: 132800,190181) TGF-beta receptor type (503 aa)
initn: 2285 init1: 1991 opt: 2314 Z-score: 836.4 bits: 164.3 E(85289): 7.5e-40
Smith-Waterman score: 2314; 69.5% identity (84.1% similar) in 511 aa overlap (3-505:2-503)
10 20 30 40 50
pF1KB4 MAESAGASSFFPLVVLLLAGSGGSGPR---GVQALLCACTSCLQANYTCETDGACMVSIF
:.: :. :..:.::...... :. :: : : : . :.:: ::: :.::.
NP_004 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT
10 20 30 40 50
60 70 80 90 100 110
pF1KB4 NLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHCCYTDYCNRIDLRVPSGHLK
. : :: ...:.: .:: : : .. .:.:: :.::.:.: :. .:
NP_004 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL--PTT-VK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB4 EPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-VYHNRQRLDMEDPSCEM-C
:.. :::::...::::: :. : ....: :.: : :.: . :::: .
NP_004 S--SPGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRTVIHHRVP-NEEDPSLDRPF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB4 LSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVA
.:. ::.::.::..::::::::::.::::.:::::::: ::::::::::::.::: .::
NP_004 ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB4 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB4 YLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIA
::::::::.:::::::::.::::::::::::::::::.::::::::::::::::: : ::
NP_004 YLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB4 DLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWE
:::::::::..:::::::::.::::::::::::::..::::::.::: :::::.:::.::
NP_004 DLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWE
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB4 IARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKM
:::::. ::.::.::::::::::::::.::::::::.::::::::: ::: ::::::.:.
NP_004 IARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKI
420 430 440 450 460 470
480 490 500
pF1KB4 MRECWYANGAARLTALRIKKTLSQLSVQEDVKI
:::::::::::::::::::::::::: :: .:.
NP_004 MRECWYANGAARLTALRIKKTLSQLSQQEGIKM
480 490 500
>>XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF-beta (438 aa)
initn: 2169 init1: 1991 opt: 2210 Z-score: 801.1 bits: 157.6 E(85289): 6.9e-38
Smith-Waterman score: 2210; 74.9% identity (88.5% similar) in 442 aa overlap (69-505:2-438)
40 50 60 70 80 90
pF1KB4 CLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHC
:: ...:.: .:: : : .. .:.:
XP_011 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYC
10 20 30
100 110 120 130 140 150
pF1KB4 CYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-
: :.::.:.: . .: .. :.. :::::...::::: :. : ....: :.:
XP_011 CNQDHCNKIELPT-TGPFSVKSSPGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRT
40 50 60 70 80
160 170 180 190 200 210
pF1KB4 VYHNRQRLDMEDPSCEM-CLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEII
: :.: . :::: . .:. ::.::.::..::::::::::.::::.:::::::: :
XP_011 VIHHRVP-NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESI
90 100 110 120 130 140
220 230 240 250 260 270
pF1KB4 GKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
:::::::::::.::: .:::::::::::::::::::::::::::::::::::::::::::
XP_011 GKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
150 160 170 180 190 200
280 290 300 310 320 330
pF1KB4 TWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAH
:::::::::::::::::::::::::::.:::::::::.::::::::::::::::::.:::
XP_011 TWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAH
210 220 230 240 250 260
340 350 360 370 380 390
pF1KB4 RDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMK
:::::::::::::: : :::::::::::..:::::::::.::::::::::::::..::::
XP_011 RDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMK
270 280 290 300 310 320
400 410 420 430 440 450
pF1KB4 HFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLR
::.::: :::::.:::.:::::::. ::.::.::::::::::::::.::::::::.::::
XP_011 HFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLR
330 340 350 360 370 380
460 470 480 490 500
pF1KB4 PNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
::::: ::: ::::::.:.:::::::::::::::::::::::::: :: .:.
XP_011 PNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
390 400 410 420 430
>>XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF-beta (438 aa)
initn: 2169 init1: 1991 opt: 2210 Z-score: 801.1 bits: 157.6 E(85289): 6.9e-38
Smith-Waterman score: 2210; 74.9% identity (88.5% similar) in 442 aa overlap (69-505:2-438)
40 50 60 70 80 90
pF1KB4 CLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHC
:: ...:.: .:: : : .. .:.:
XP_016 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYC
10 20 30
100 110 120 130 140 150
pF1KB4 CYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-
: :.::.:.: . .: .. :.. :::::...::::: :. : ....: :.:
XP_016 CNQDHCNKIELPT-TGPFSVKSSPGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRT
40 50 60 70 80
160 170 180 190 200 210
pF1KB4 VYHNRQRLDMEDPSCEM-CLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEII
: :.: . :::: . .:. ::.::.::..::::::::::.::::.:::::::: :
XP_016 VIHHRVP-NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESI
90 100 110 120 130 140
220 230 240 250 260 270
pF1KB4 GKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
:::::::::::.::: .:::::::::::::::::::::::::::::::::::::::::::
XP_016 GKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
150 160 170 180 190 200
280 290 300 310 320 330
pF1KB4 TWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAH
:::::::::::::::::::::::::::.:::::::::.::::::::::::::::::.:::
XP_016 TWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAH
210 220 230 240 250 260
340 350 360 370 380 390
pF1KB4 RDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMK
:::::::::::::: : :::::::::::..:::::::::.::::::::::::::..::::
XP_016 RDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMK
270 280 290 300 310 320
400 410 420 430 440 450
pF1KB4 HFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLR
::.::: :::::.:::.:::::::. ::.::.::::::::::::::.::::::::.::::
XP_016 HFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLR
330 340 350 360 370 380
460 470 480 490 500
pF1KB4 PNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
::::: ::: ::::::.:.:::::::::::::::::::::::::: :: .:.
XP_016 PNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
390 400 410 420 430
>>XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF-beta (434 aa)
initn: 2176 init1: 1991 opt: 2197 Z-score: 796.7 bits: 156.7 E(85289): 1.2e-37
Smith-Waterman score: 2197; 75.1% identity (88.2% similar) in 442 aa overlap (69-505:2-434)
40 50 60 70 80 90
pF1KB4 CLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHC
:: ...:.: .:: : : .. .:.:
XP_011 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYC
10 20 30
100 110 120 130 140 150
pF1KB4 CYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQR-
: :.::.:.: :. .: :.. :::::...::::: :. : ....: :.:
XP_011 CNQDHCNKIEL--PTT-VKSS--PGL-GPVELAAVIAGPVC--FVCISLMLMVYICHNRT
40 50 60 70 80
160 170 180 190 200 210
pF1KB4 VYHNRQRLDMEDPSCEM-CLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEII
: :.: . :::: . .:. ::.::.::..::::::::::.::::.:::::::: :
XP_011 VIHHRVP-NEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESI
90 100 110 120 130 140
220 230 240 250 260 270
pF1KB4 GKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
:::::::::::.::: .:::::::::::::::::::::::::::::::::::::::::::
XP_011 GKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNG
150 160 170 180 190 200
280 290 300 310 320 330
pF1KB4 TWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAH
:::::::::::::::::::::::::::.:::::::::.::::::::::::::::::.:::
XP_011 TWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAH
210 220 230 240 250 260
340 350 360 370 380 390
pF1KB4 RDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMK
:::::::::::::: : :::::::::::..:::::::::.::::::::::::::..::::
XP_011 RDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMK
270 280 290 300 310 320
400 410 420 430 440 450
pF1KB4 HFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLR
::.::: :::::.:::.:::::::. ::.::.::::::::::::::.::::::::.::::
XP_011 HFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLR
330 340 350 360 370 380
460 470 480 490 500
pF1KB4 PNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
::::: ::: ::::::.:.:::::::::::::::::::::::::: :: .:.
XP_011 PNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
390 400 410 420 430
>>NP_660302 (OMIM: 608981) activin receptor type-1C isof (493 aa)
initn: 2108 init1: 1847 opt: 2157 Z-score: 782.4 bits: 154.3 E(85289): 7.6e-37
Smith-Waterman score: 2165; 65.8% identity (84.7% similar) in 491 aa overlap (15-504:13-492)
10 20 30 40 50 60
pF1KB4 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
.::::... .: .: :.: : ..:.::.:.::: .:.. .
NP_660 MTRALCSALRQALLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTN
10 20 30 40 50
70 80 90 100 110 120
pF1KB4 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
: :. ...:. :: . .: ::... .:.::.::.:: : :..:.. :. :.
NP_660 GKEQVIKSCVSLPEL---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTAS---PNAPK
60 70 80 90 100
130 140 150 160 170
pF1KB4 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKTL
. ::.::. ::. :: :: . ... . . .: :....: ..:.: : : . :::
NP_660 L-GPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB4 QDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSR
.::.::...:::::::::.::::.:::::::::.:::::::::.::: : ::::::::::
NP_660 KDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSR
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB4 EERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTV
.::::::::::::::::::::::::::::::::::::::::::.:::.:::.::::: :
NP_660 DERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIV
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB4 TIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVR
:. :::::::: ::::::::::::::::::.:::::.::::::::: ::::::::::.
NP_660 TVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVK
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB4 HDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS
::.. .:::: : .::::::::::.::.:.:.. :.::: ::::..:::::::::::.
NP_660 HDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV
350 360 370 380 390 400
420 430 440 450 460 470
pF1KB4 GGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYA
::. :::::::::.::::::::::::::::::.::.::: ::: :::::::..:::::::
NP_660 GGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYA
410 420 430 440 450 460
480 490 500
pF1KB4 NGAARLTALRIKKTLSQLSVQEDVKI
::::::::::::::.::: :.:: :
NP_660 NGAARLTALRIKKTISQLCVKEDCKA
470 480 490
>>NP_001104501 (OMIM: 608981) activin receptor type-1C i (443 aa)
initn: 1980 init1: 1847 opt: 2056 Z-score: 748.1 bits: 147.8 E(85289): 6.3e-35
Smith-Waterman score: 2056; 68.6% identity (86.1% similar) in 446 aa overlap (60-504:4-442)
30 40 50 60 70 80
pF1KB4 QALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSED
.: :. ...:. :: . .: ::..
NP_001 MLTNGKEQVIKSCVSLPEL---NAQVFCHSSNN
10 20 30
90 100 110 120 130 140
pF1KB4 LRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVI
. .:.::.::.:: : :..:.. :. :.. ::.::. ::. :: :: . ... .
NP_001 VTKTECCFTDFCNNITLHLPTA---SPNAPKL-GPMELAIIITVPVCLLSIAAMLTVWAC
40 50 60 70 80
150 160 170 180 190 200
pF1KB4 NYHQRVYHNRQRLDMEDPSCEMCL-SKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIV
. .: :....: ..:.: : : . :::.::.::...:::::::::.::::.:::::
NP_001 QGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIV
90 100 110 120 130 140
210 220 230 240 250 260
pF1KB4 LQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAAD
::::.:::::::::.::: : ::::::::::.::::::::::::::::::::::::::::
NP_001 LQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAAD
150 160 170 180 190 200
270 280 290 300 310 320
pF1KB4 NKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGK
::::::::::::::.:::.:::.::::: ::. :::::::: :::::::::::::::::
NP_001 NKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGK
210 220 230 240 250 260
330 340 350 360 370 380
pF1KB4 PGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDE
:.:::::.::::::::: ::::::::::.::.. .:::: : .::::::::::.::.
NP_001 PAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDD
270 280 290 300 310 320
390 400 410 420 430 440
pF1KB4 TINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVC
:.:.. :.::: ::::..:::::::::::. ::. :::::::::.:::::::::::::::
NP_001 TMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVC
330 340 350 360 370 380
450 460 470 480 490 500
pF1KB4 DQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
:::.::.::: ::: :::::::..:::::::::::::::::::::.::: :.:: :
NP_001 DQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
390 400 410 420 430 440
505 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 15:06:41 2016 done: Thu Nov 3 15:06:43 2016
Total Scan time: 9.460 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]