Result of FASTA (omim) for
pFN21AB4351
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4351, 360 aa
1>>>pF1KB4351 360 - 360 aa - 360 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.0325+/-0.00071; mu= -34.7235+/- 0.042
mean_var=806.3878+/-184.748, 0's: 0 Z-trim(113.1): 1319 B-trim: 452 in 1/51
Lambda= 0.045165
statistics sampled from 20603 (22274) to 20603 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.616), E-opt: 0.2 (0.261), width: 16
Scan time: 7.700
The best scores are: opt bits E(85289)
NP_620407 (OMIM: 176948) mitogen-activated protein ( 360) 2432 174.7 2.8e-43
NP_002736 (OMIM: 176948) mitogen-activated protein ( 360) 2432 174.7 2.8e-43
NP_002737 (OMIM: 601795) mitogen-activated protein ( 379) 2109 153.7 6.3e-37
NP_001035145 (OMIM: 601795) mitogen-activated prot ( 357) 1910 140.7 4.8e-33
NP_001103361 (OMIM: 601795) mitogen-activated prot ( 335) 1441 110.1 7.3e-24
NP_002740 (OMIM: 602521) mitogen-activated protein ( 816) 1139 90.8 1.1e-17
NP_620603 (OMIM: 602521) mitogen-activated protein ( 816) 1139 90.8 1.1e-17
NP_620602 (OMIM: 602521) mitogen-activated protein ( 816) 1139 90.8 1.1e-17
NP_620581 (OMIM: 600289) mitogen-activated protein ( 360) 1095 87.6 4.7e-17
NP_001306 (OMIM: 600289) mitogen-activated protein ( 360) 1081 86.7 8.9e-17
NP_002742 (OMIM: 602898) mitogen-activated protein ( 364) 1051 84.7 3.5e-16
XP_011512612 (OMIM: 600289) PREDICTED: mitogen-act ( 401) 1003 81.7 3.2e-15
NP_002745 (OMIM: 602899) mitogen-activated protein ( 365) 985 80.4 6.8e-15
NP_002960 (OMIM: 602399) mitogen-activated protein ( 367) 968 79.3 1.5e-14
XP_006715061 (OMIM: 600289) PREDICTED: mitogen-act ( 283) 909 75.4 1.8e-13
XP_006721620 (OMIM: 602521) PREDICTED: mitogen-act ( 822) 915 76.3 2.8e-13
XP_006721621 (OMIM: 602521) PREDICTED: mitogen-act ( 822) 915 76.3 2.8e-13
XP_006721622 (OMIM: 602521) PREDICTED: mitogen-act ( 822) 915 76.3 2.8e-13
NP_620582 (OMIM: 600289) mitogen-activated protein ( 297) 895 74.5 3.5e-13
XP_016865790 (OMIM: 600289) PREDICTED: mitogen-act ( 301) 890 74.2 4.4e-13
XP_016863927 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 893 74.5 4.5e-13
XP_016863928 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 893 74.5 4.5e-13
XP_016863926 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 893 74.5 4.5e-13
XP_016863923 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 893 74.5 4.5e-13
XP_016863924 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 893 74.5 4.5e-13
XP_016863925 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 893 74.5 4.5e-13
XP_011524377 (OMIM: 176949) PREDICTED: mitogen-act ( 587) 899 75.1 4.6e-13
XP_016881328 (OMIM: 176949) PREDICTED: mitogen-act ( 587) 899 75.1 4.6e-13
XP_005258356 (OMIM: 176949) PREDICTED: mitogen-act ( 587) 899 75.1 4.6e-13
XP_011524378 (OMIM: 176949) PREDICTED: mitogen-act ( 587) 899 75.1 4.6e-13
NP_002738 (OMIM: 176949) mitogen-activated protein ( 587) 899 75.1 4.6e-13
XP_011524376 (OMIM: 176949) PREDICTED: mitogen-act ( 587) 899 75.1 4.6e-13
XP_016865788 (OMIM: 600289) PREDICTED: mitogen-act ( 328) 890 74.2 4.6e-13
NP_002744 (OMIM: 602897) mitogen-activated protein ( 422) 893 74.5 4.8e-13
XP_016863918 (OMIM: 602897) PREDICTED: mitogen-act ( 422) 893 74.5 4.8e-13
XP_016863920 (OMIM: 602897) PREDICTED: mitogen-act ( 422) 893 74.5 4.8e-13
XP_016863921 (OMIM: 602897) PREDICTED: mitogen-act ( 422) 893 74.5 4.8e-13
XP_005263192 (OMIM: 602897) PREDICTED: mitogen-act ( 422) 893 74.5 4.8e-13
XP_016863919 (OMIM: 602897) PREDICTED: mitogen-act ( 422) 893 74.5 4.8e-13
XP_016863912 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 893 74.5 4.8e-13
XP_011530422 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 893 74.5 4.8e-13
XP_011530423 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 893 74.5 4.8e-13
XP_006714331 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 893 74.5 4.8e-13
NP_620446 (OMIM: 602897) mitogen-activated protein ( 426) 893 74.5 4.8e-13
XP_016863914 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 893 74.5 4.8e-13
XP_016863913 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 893 74.5 4.8e-13
XP_016863915 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 893 74.5 4.8e-13
XP_016863909 (OMIM: 602897) PREDICTED: mitogen-act ( 464) 893 74.6 5.1e-13
XP_005263186 (OMIM: 602897) PREDICTED: mitogen-act ( 464) 893 74.6 5.1e-13
XP_011530420 (OMIM: 602897) PREDICTED: mitogen-act ( 464) 893 74.6 5.1e-13
>>NP_620407 (OMIM: 176948) mitogen-activated protein kin (360 aa)
initn: 2432 init1: 2432 opt: 2432 Z-score: 898.0 bits: 174.7 E(85289): 2.8e-43
Smith-Waterman score: 2432; 100.0% identity (100.0% similar) in 360 aa overlap (1-360:1-360)
10 20 30 40 50 60
pF1KB4 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
310 320 330 340 350 360
>>NP_002736 (OMIM: 176948) mitogen-activated protein kin (360 aa)
initn: 2432 init1: 2432 opt: 2432 Z-score: 898.0 bits: 174.7 E(85289): 2.8e-43
Smith-Waterman score: 2432; 100.0% identity (100.0% similar) in 360 aa overlap (1-360:1-360)
10 20 30 40 50 60
pF1KB4 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
310 320 330 340 350 360
>>NP_002737 (OMIM: 601795) mitogen-activated protein kin (379 aa)
initn: 2138 init1: 2105 opt: 2109 Z-score: 783.9 bits: 153.7 E(85289): 6.3e-37
Smith-Waterman score: 2109; 86.5% identity (94.4% similar) in 356 aa overlap (8-357:19-374)
10 20 30 40
pF1KB4 MAAAAAAGAGP------EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAY
:.:: :::.:: ::::::::.:.:::::::::: :::
NP_002 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB4 DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYI
:.: :.:::::::::::::::::::::::.:::::::::.::: ::.:: :.: :.::::
NP_002 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB4 VQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL
::::::::::::::.:.::::::::::::::::::::::::::::::::::::.::::::
NP_002 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB4 KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
:::::::::.:::.::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB4 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD
::::::::::::::::::::::::::::::::::.:::::: ::: :.:: : .:::..:
NP_002 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB4 SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKL
::::::::.::::::.::: ::.:::::::::::::.:::.:: :: : :::::::::.:
NP_002 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
310 320 330 340 350 360
350 360
pF1KB4 KELIFEETARFQPGYRS
:::::.::::::::
NP_002 KELIFQETARFQPGVLEAP
370
>>NP_001035145 (OMIM: 601795) mitogen-activated protein (357 aa)
initn: 1934 init1: 1901 opt: 1910 Z-score: 714.2 bits: 140.7 E(85289): 4.8e-33
Smith-Waterman score: 1910; 85.6% identity (94.5% similar) in 327 aa overlap (8-328:19-344)
10 20 30 40
pF1KB4 MAAAAAAGAGP------EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAY
:.:: :::.:: ::::::::.:.:::::::::: :::
NP_001 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB4 DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYI
:.: :.:::::::::::::::::::::::.:::::::::.::: ::.:: :.: :.::::
NP_001 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB4 VQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL
::::::::::::::.:.::::::::::::::::::::::::::::::::::::.::::::
NP_001 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB4 KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
:::::::::.:::.::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB4 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD
::::::::::::::::::::::::::::::::::.:::::: ::: :.:: : .:::..:
NP_001 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB4 SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKL
::::::::.::::::.::: ::.:::::::::::::.:: ....:
NP_001 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDE-VGQSPAAVGLGAGEQGGT
310 320 330 340 350
350 360
pF1KB4 KELIFEETARFQPGYRS
>>NP_001103361 (OMIM: 601795) mitogen-activated protein (335 aa)
initn: 1470 init1: 1437 opt: 1441 Z-score: 549.4 bits: 110.1 E(85289): 7.3e-24
Smith-Waterman score: 1768; 76.7% identity (83.1% similar) in 356 aa overlap (8-357:19-330)
10 20 30 40
pF1KB4 MAAAAAAGAGP------EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAY
:.:: :::.:: ::::::::.:.:::::::::: :::
NP_001 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB4 DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYI
:.: :.:::::::::::::::::::::::.:::::::::.::: ::.:: :.: :.::::
NP_001 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB4 VQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL
::::::::::::::.:.::::::::::::::::::::::::::::::::::::.::::::
NP_001 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB4 KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
:::::::::.:::.::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB4 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD
::::::::::::::::::
NP_001 NRPIFPGKHYLDQLNHIL------------------------------------------
250
290 300 310 320 330 340
pF1KB4 SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKL
::::::.::::::.::: ::.:::::::::::::.:::.:: :: : :::::::::.:
NP_001 --ALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
260 270 280 290 300 310
350 360
pF1KB4 KELIFEETARFQPGYRS
:::::.::::::::
NP_001 KELIFQETARFQPGVLEAP
320 330
>>NP_002740 (OMIM: 602521) mitogen-activated protein kin (816 aa)
initn: 1043 init1: 590 opt: 1139 Z-score: 438.3 bits: 90.8 E(85289): 1.1e-17
Smith-Waterman score: 1139; 50.9% identity (76.3% similar) in 342 aa overlap (19-355:49-389)
10 20 30 40
pF1KB4 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNK
:::: .: . ::.::::.: :: ..
NP_002 GPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTG
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB4 VRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIE--QMKDVYIVQ
.:::::: . :. : .:::::.::: .:.:.:::.:.::.: ::. ..:.::.:
NP_002 QQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILR-PTVPYGEFKSVYVVL
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB4 DLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLK
::::.::...... : :. .:. :::::.::::::.:::.:.::::::::::.: .:.::
NP_002 DLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELK
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB4 ICDFGLAR-VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
: :::.:: . .: :.:::::::::::::.::. . ::..::.::::::..:::.
NP_002 IGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLA
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB4 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD
: .::::.:. ::. :. .::.:: .. . ..: :. ::: .. :::. ..:.::
NP_002 RRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB4 SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKL
.::.:: .:: :.: :: . :: ::.: .:.::.::: :: : .. . : .:..
NP_002 RQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERI
320 330 340 350 360 370
350 360
pF1KB4 KELIFEETARFQPGYRS
:: : : :.
NP_002 KEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPA
380 390 400 410 420 430
>>NP_620603 (OMIM: 602521) mitogen-activated protein kin (816 aa)
initn: 1043 init1: 590 opt: 1139 Z-score: 438.3 bits: 90.8 E(85289): 1.1e-17
Smith-Waterman score: 1139; 50.9% identity (76.3% similar) in 342 aa overlap (19-355:49-389)
10 20 30 40
pF1KB4 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNK
:::: .: . ::.::::.: :: ..
NP_620 GPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTG
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB4 VRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIE--QMKDVYIVQ
.:::::: . :. : .:::::.::: .:.:.:::.:.::.: ::. ..:.::.:
NP_620 QQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILR-PTVPYGEFKSVYVVL
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB4 DLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLK
::::.::...... : :. .:. :::::.::::::.:::.:.::::::::::.: .:.::
NP_620 DLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELK
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB4 ICDFGLAR-VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
: :::.:: . .: :.:::::::::::::.::. . ::..::.::::::..:::.
NP_620 IGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLA
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB4 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD
: .::::.:. ::. :. .::.:: .. . ..: :. ::: .. :::. ..:.::
NP_620 RRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB4 SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKL
.::.:: .:: :.: :: . :: ::.: .:.::.::: :: : .. . : .:..
NP_620 RQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERI
320 330 340 350 360 370
350 360
pF1KB4 KELIFEETARFQPGYRS
:: : : :.
NP_620 KEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPA
380 390 400 410 420 430
>>NP_620602 (OMIM: 602521) mitogen-activated protein kin (816 aa)
initn: 1043 init1: 590 opt: 1139 Z-score: 438.3 bits: 90.8 E(85289): 1.1e-17
Smith-Waterman score: 1139; 50.9% identity (76.3% similar) in 342 aa overlap (19-355:49-389)
10 20 30 40
pF1KB4 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNK
:::: .: . ::.::::.: :: ..
NP_620 GPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTG
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB4 VRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIE--QMKDVYIVQ
.:::::: . :. : .:::::.::: .:.:.:::.:.::.: ::. ..:.::.:
NP_620 QQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILR-PTVPYGEFKSVYVVL
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB4 DLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLK
::::.::...... : :. .:. :::::.::::::.:::.:.::::::::::.: .:.::
NP_620 DLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELK
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB4 ICDFGLAR-VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
: :::.:: . .: :.:::::::::::::.::. . ::..::.::::::..:::.
NP_620 IGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLA
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB4 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD
: .::::.:. ::. :. .::.:: .. . ..: :. ::: .. :::. ..:.::
NP_620 RRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB4 SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKL
.::.:: .:: :.: :: . :: ::.: .:.::.::: :: : .. . : .:..
NP_620 RQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERI
320 330 340 350 360 370
350 360
pF1KB4 KELIFEETARFQPGYRS
:: : : :.
NP_620 KEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPA
380 390 400 410 420 430
>>NP_620581 (OMIM: 600289) mitogen-activated protein kin (360 aa)
initn: 1056 init1: 503 opt: 1095 Z-score: 427.1 bits: 87.6 E(85289): 4.7e-17
Smith-Waterman score: 1095; 49.0% identity (76.5% similar) in 341 aa overlap (18-356:17-350)
10 20 30 40 50
pF1KB4 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PF
...: :: ::: .: :::: ::.:.:. . .:::.::.: ::
NP_620 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF
10 20 30 40 50
60 70 80 90 100 110
pF1KB4 EHQTYCQRTLREIKILLRFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKT
. . .:: ::...: ...:::.::. :.. : ..:...:::.: :: .:: ...:
NP_620 QSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB4 QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH
:.:..::. ...:::::::::::::...::::::::: .: :.::: :::::: .: .
NP_620 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB4 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLN
.: ::::::::::::::: :....::::::::.::.:..: .::: ..:::.
NP_620 -----MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB4 HILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNP
:: ..:.:. : :. : . .::::. :: . :. . .: .:. :.:::.:::...
NP_620 LILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDS
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB4 HKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGY
::: . ::::: :. ::.::.:::.:. :. ..: :: .. : : ..:. : :
NP_620 DKRITAAQALAHAYFAQYHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISFVPPP
300 310 320 330 340 350
360
pF1KB4 RS
NP_620 LDQEEMES
360
>>NP_001306 (OMIM: 600289) mitogen-activated protein kin (360 aa)
initn: 1042 init1: 489 opt: 1081 Z-score: 422.2 bits: 86.7 E(85289): 8.9e-17
Smith-Waterman score: 1081; 47.8% identity (76.0% similar) in 341 aa overlap (18-356:17-350)
10 20 30 40 50
pF1KB4 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PF
...: :: ::: .: :::: ::.:.:. . .:::.::.: ::
NP_001 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF
10 20 30 40 50
60 70 80 90 100 110
pF1KB4 EHQTYCQRTLREIKILLRFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKT
. . .:: ::...: ...:::.::. :.. : ..:...:::.: :: .:: ...:
NP_001 QSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB4 QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH
:.:..::. ...:::::::::::::...::::::::: .: :.::: :::::: .: .
NP_001 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB4 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLN
.: ::::::::::::::: :....::::::::.::.:..: .::: ...::.
NP_001 -----MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB4 HILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNP
.:. . :.: .: . . .::::. :: . :. . .: .:. :.:::.:::...
NP_001 QIMRLTGTPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDS
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB4 HKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGY
::: . ::::: :. ::.::.:::.:. :. ..: :: .. : : ..:. : :
NP_001 DKRITAAQALAHAYFAQYHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISFVPPP
300 310 320 330 340 350
360
pF1KB4 RS
NP_001 LDQEEMES
360
360 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 14:48:27 2016 done: Thu Nov 3 14:48:28 2016
Total Scan time: 7.700 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]