Result of FASTA (ccds) for
pFN21AB3765
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3765, 467 aa
1>>>pF1KB3765 467 - 467 aa - 467 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6622+/-0.000984; mu= 16.7425+/- 0.059
mean_var=80.3058+/-15.694, 0's: 0 Z-trim(105.7): 16 B-trim: 0 in 0/51
Lambda= 0.143120
statistics sampled from 8548 (8555) to 8548 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.629), E-opt: 0.2 (0.263), width: 16
Scan time: 2.700
The best scores are: opt bits E(32554)
CCDS9812.1 PSEN1 gene_id:5663|Hs108|chr14 ( 467) 3038 637.1 1.1e-182
CCDS9813.1 PSEN1 gene_id:5663|Hs108|chr14 ( 463) 2996 628.5 4.6e-180
CCDS1556.1 PSEN2 gene_id:5664|Hs108|chr1 ( 448) 1309 280.1 3.2e-75
CCDS44324.1 PSEN2 gene_id:5664|Hs108|chr1 ( 447) 1300 278.3 1.2e-74
>>CCDS9812.1 PSEN1 gene_id:5663|Hs108|chr14 (467 aa)
initn: 3038 init1: 3038 opt: 3038 Z-score: 3393.0 bits: 637.1 E(32554): 1.1e-182
Smith-Waterman score: 3038; 100.0% identity (100.0% similar) in 467 aa overlap (1-467:1-467)
10 20 30 40 50 60
pF1KB3 MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
370 380 390 400 410 420
430 440 450 460
pF1KB3 TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
430 440 450 460
>>CCDS9813.1 PSEN1 gene_id:5663|Hs108|chr14 (463 aa)
initn: 2854 init1: 2854 opt: 2996 Z-score: 3346.2 bits: 628.5 E(32554): 4.6e-180
Smith-Waterman score: 2996; 99.1% identity (99.1% similar) in 467 aa overlap (1-467:1-463)
10 20 30 40 50 60
pF1KB3 MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
CCDS98 MTELPAPLSYFQNAQMSEDNHLSNT----NDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB3 DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB3 GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB3 VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
360 370 380 390 400 410
430 440 450 460
pF1KB3 TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS98 TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
420 430 440 450 460
>>CCDS1556.1 PSEN2 gene_id:5664|Hs108|chr1 (448 aa)
initn: 1864 init1: 1291 opt: 1309 Z-score: 1463.9 bits: 280.1 E(32554): 3.2e-75
Smith-Waterman score: 1841; 65.9% identity (79.4% similar) in 466 aa overlap (3-467:24-448)
10 20 30
pF1KB3 MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHN
: :.: : .. : ::.. . :::..... .:
CCDS15 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB3 DRRSL-GHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVA
:: : : ::: : .:::::::::::::::::::::::.::::
CCDS15 DRYVCSGVP-----GRPPG-----------LEEELTLKYGAKHVIMLFVPVTLCMIVVVA
70 80 90 100
100 110 120 130 140 150
pF1KB3 TIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRC
::::: :::.:.:::::::::::: .:::: :.:.::. :::::::::::.:::::::::
CCDS15 TIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRC
110 120 130 140 150 160
160 170 180 190 200 210
pF1KB3 YKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGP
:: ::.:::.:::.:::.:..::::::.::::::.:: :. : .::::.:::. ::::::
CCDS15 YKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGP
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB3 LRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQER
: ::::::::::::::::::::::::.::.::..::::::::::::::::::::::::::
CCDS15 LVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQER
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB3 NETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSE
:: .::::::::.::: :.::. :: .: .. :. : :..: :. .: . . :
CCDS15 NEPIFPALIYSSAMVWTVGMAKLDPSSQGALQL--PYDPE-MEEDSYDSFGEPS---YPE
290 300 310 320 330
340 350 360 370 380 390
pF1KB3 EWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASA
.: : . : .:: :. ::::::::::::::::::::::.:
CCDS15 VFEP-------PLTGYPG-----EEL-------EEEEERGVKLGLGDFIFYSVLVGKAAA
340 350 360 370
400 410 420 430 440 450
pF1KB3 TASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMD
:.:::::::.::::::::::::::::::.::::::::::::::::.:::.:: ::.::::
CCDS15 TGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMD
380 390 400 410 420 430
460
pF1KB3 QLAFHQFYI
:: ::.::
CCDS15 TLASHQLYI
440
>>CCDS44324.1 PSEN2 gene_id:5664|Hs108|chr1 (447 aa)
initn: 1887 init1: 1289 opt: 1300 Z-score: 1453.9 bits: 278.3 E(32554): 1.2e-74
Smith-Waterman score: 1832; 65.7% identity (79.2% similar) in 466 aa overlap (3-467:24-447)
10 20 30
pF1KB3 MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHN
: :.: : .. : ::.. . :::..... .:
CCDS44 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB3 DRRSL-GHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVA
:: : : ::: : .:::::::::::::::::::::::.::::
CCDS44 DRYVCSGVP-----GRPPG-----------LEEELTLKYGAKHVIMLFVPVTLCMIVVVA
70 80 90 100
100 110 120 130 140 150
pF1KB3 TIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRC
::::: :::.:.:::::::::::: .:::: :.:.::. :::::::::::.:::::::::
CCDS44 TIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRC
110 120 130 140 150 160
160 170 180 190 200 210
pF1KB3 YKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGP
:: ::.:::.:::.:::.:..::::::.::::::.:: :. : .::::.:::. ::::::
CCDS44 YKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGP
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB3 LRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQER
: ::::::::::::::::::::::::.::.::..::::::::::::::::::::::::::
CCDS44 LVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQER
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB3 NETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSE
:: .::::::::.::: :.::. :: .: .. :. : ..: :. .: . . :
CCDS44 NEPIFPALIYSSAMVWTVGMAKLDPSSQGALQL--PYDPEM--EDSYDSFGEPS---YPE
290 300 310 320 330
340 350 360 370 380 390
pF1KB3 EWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASA
.: : . : .:: :. ::::::::::::::::::::::.:
CCDS44 VFEP-------PLTGYPG-----EEL-------EEEEERGVKLGLGDFIFYSVLVGKAAA
340 350 360 370
400 410 420 430 440 450
pF1KB3 TASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMD
:.:::::::.::::::::::::::::::.::::::::::::::::.:::.:: ::.::::
CCDS44 TGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMD
380 390 400 410 420 430
460
pF1KB3 QLAFHQFYI
:: ::.::
CCDS44 TLASHQLYI
440
467 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:54:47 2016 done: Thu Nov 3 13:54:48 2016
Total Scan time: 2.700 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]