Result of FASTA (omim) for
pFN21AB3419
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3419, 800 aa
1>>>pF1KB3419 800 - 800 aa - 800 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.0338+/-0.000578; mu= -22.9370+/- 0.036
mean_var=714.0750+/-161.402, 0's: 0 Z-trim(116.1): 1306 B-trim: 1499 in 1/59
Lambda= 0.047996
statistics sampled from 25245 (27004) to 25245 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.317), width: 16
Scan time: 13.340
The best scores are: opt bits E(85289)
NP_057737 (OMIM: 609479,616890) mitogen-activated ( 800) 5398 390.6 1.4e-107
XP_005246697 (OMIM: 609479,616890) PREDICTED: mito ( 800) 5398 390.6 1.4e-107
XP_016859813 (OMIM: 609479,616890) PREDICTED: mito ( 455) 2221 170.4 1.6e-41
XP_016859812 (OMIM: 609479,616890) PREDICTED: mito ( 455) 2221 170.4 1.6e-41
NP_598407 (OMIM: 609479,616890) mitogen-activated ( 455) 2221 170.4 1.6e-41
XP_005269197 (OMIM: 600447) PREDICTED: mitogen-act ( 453) 739 67.8 1.2e-10
XP_016875445 (OMIM: 600447) PREDICTED: mitogen-act ( 859) 739 68.1 1.9e-10
NP_006292 (OMIM: 600447) mitogen-activated protein ( 859) 739 68.1 1.9e-10
NP_001180440 (OMIM: 600447) mitogen-activated prot ( 892) 739 68.1 1.9e-10
XP_005269195 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 739 68.1 1.9e-10
XP_006719651 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 739 68.1 1.9e-10
XP_011537027 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 739 68.1 1.9e-10
XP_016862946 (OMIM: 604915) PREDICTED: mitogen-act ( 817) 714 66.3 6e-10
XP_016862945 (OMIM: 604915) PREDICTED: mitogen-act ( 966) 714 66.4 6.8e-10
NP_001229243 (OMIM: 604915) mitogen-activated prot ( 966) 714 66.4 6.8e-10
NP_004712 (OMIM: 604915) mitogen-activated protein ( 966) 714 66.4 6.8e-10
XP_011511612 (OMIM: 604915) PREDICTED: mitogen-act ( 966) 714 66.4 6.8e-10
XP_005267740 (OMIM: 600136) PREDICTED: mitogen-act (1081) 704 65.8 1.2e-09
NP_001271159 (OMIM: 600136) mitogen-activated prot (1104) 704 65.8 1.2e-09
NP_149132 (OMIM: 600136) mitogen-activated protein (1118) 704 65.8 1.2e-09
XP_011535090 (OMIM: 600136) PREDICTED: mitogen-act (1166) 704 65.8 1.2e-09
NP_002410 (OMIM: 600050) mitogen-activated protein ( 847) 693 64.9 1.7e-09
NP_002437 (OMIM: 600137) mitogen-activated protein ( 954) 691 64.8 2e-09
XP_011525284 (OMIM: 600137) PREDICTED: mitogen-act ( 860) 662 62.7 7.6e-09
XP_011525283 (OMIM: 600137) PREDICTED: mitogen-act ( 962) 662 62.8 8.2e-09
NP_001229246 (OMIM: 604915) mitogen-activated prot ( 759) 624 60.1 4.3e-08
XP_011542607 (OMIM: 614793) PREDICTED: mitogen-act ( 905) 601 58.5 1.5e-07
NP_115811 (OMIM: 614793) mitogen-activated protein (1036) 601 58.6 1.6e-07
XP_016862948 (OMIM: 604915) PREDICTED: mitogen-act ( 734) 592 57.8 2e-07
XP_016862947 (OMIM: 604915) PREDICTED: mitogen-act ( 734) 592 57.8 2e-07
NP_663306 (OMIM: 157800,602614,617137) mitogen-act ( 491) 571 56.2 4.1e-07
NP_663305 (OMIM: 157800,602614,617137) mitogen-act ( 518) 571 56.2 4.3e-07
NP_003179 (OMIM: 157800,602614,617137) mitogen-act ( 579) 571 56.3 4.6e-07
NP_663304 (OMIM: 157800,602614,617137) mitogen-act ( 606) 571 56.3 4.7e-07
NP_001161711 (OMIM: 164690) Abelson tyrosine-prote (1043) 559 55.7 1.2e-06
NP_001161710 (OMIM: 164690) Abelson tyrosine-prote (1058) 559 55.7 1.2e-06
NP_001129472 (OMIM: 164690) Abelson tyrosine-prote (1064) 559 55.7 1.2e-06
NP_001161709 (OMIM: 164690) Abelson tyrosine-prote (1079) 559 55.7 1.2e-06
XP_005245145 (OMIM: 164690) PREDICTED: Abelson tyr (1146) 559 55.7 1.3e-06
NP_001161708 (OMIM: 164690) Abelson tyrosine-prote (1161) 559 55.8 1.3e-06
NP_005149 (OMIM: 164690) Abelson tyrosine-protein (1167) 559 55.8 1.3e-06
XP_016856524 (OMIM: 164690) PREDICTED: Abelson tyr (1182) 559 55.8 1.3e-06
NP_009298 (OMIM: 164690) Abelson tyrosine-protein (1182) 559 55.8 1.3e-06
NP_001129473 (OMIM: 164690) Abelson tyrosine-prote ( 542) 528 53.2 3.5e-06
NP_005148 (OMIM: 189980) tyrosine-protein kinase A (1130) 535 54.1 4e-06
NP_009297 (OMIM: 189980) tyrosine-protein kinase A (1149) 535 54.1 4.1e-06
XP_016866143 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 499 51.2 1.4e-05
XP_016866141 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 499 51.2 1.4e-05
XP_016866139 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 499 51.2 1.4e-05
XP_016866142 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 499 51.2 1.4e-05
>>NP_057737 (OMIM: 609479,616890) mitogen-activated prot (800 aa)
initn: 5398 init1: 5398 opt: 5398 Z-score: 2052.5 bits: 390.6 E(85289): 1.4e-107
Smith-Waterman score: 5398; 99.9% identity (99.9% similar) in 800 aa overlap (1-800:1-800)
10 20 30 40 50 60
pF1KB3 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP
730 740 750 760 770 780
790 800
pF1KB3 SPATTNKERARGDHRGWRNF
::: ::::::::::::::::
NP_057 SPAKTNKERARGDHRGWRNF
790 800
>>XP_005246697 (OMIM: 609479,616890) PREDICTED: mitogen- (800 aa)
initn: 5398 init1: 5398 opt: 5398 Z-score: 2052.5 bits: 390.6 E(85289): 1.4e-107
Smith-Waterman score: 5398; 99.9% identity (99.9% similar) in 800 aa overlap (1-800:1-800)
10 20 30 40 50 60
pF1KB3 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP
730 740 750 760 770 780
790 800
pF1KB3 SPATTNKERARGDHRGWRNF
::: ::::::::::::::::
XP_005 SPAKTNKERARGDHRGWRNF
790 800
>>XP_016859813 (OMIM: 609479,616890) PREDICTED: mitogen- (455 aa)
initn: 2215 init1: 2215 opt: 2221 Z-score: 866.6 bits: 170.4 E(85289): 1.6e-41
Smith-Waterman score: 2226; 78.2% identity (86.6% similar) in 455 aa overlap (1-454:1-441)
10 20 30 40 50 60
pF1KB3 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
::::::::::::::::::::::::::::::: . ..: .. : . . ..:::
XP_016 LSFKEQELKERERRLKMWEQKLTEQSNTPLL--LPLAARMSEESYFESKT---EESNSAE
310 320 330 340 350
370 380 390 400 410 420
pF1KB3 MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
:: .. .: :. . . .:. : ... : :. ...: . :. ...
XP_016 MS--CQITATSNGEGHGM----NPSLQAMMLMGFGDIFSMNKA-GAVMHSGMQINM--QA
360 370 380 390 400
430 440 450 460 470
pF1KB3 IKDSGGEPEENEEKIVNLELVFG-FHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFN
..:. . . : ::. : :. : :. : .:
XP_016 KQNSSKTTSKRRGKKVNMALGFSDFDLSEGDDDDDDDGEEEDNDMDNSE
410 420 430 440 450
480 490 500 510 520 530
pF1KB3 TNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKP
>>XP_016859812 (OMIM: 609479,616890) PREDICTED: mitogen- (455 aa)
initn: 2215 init1: 2215 opt: 2221 Z-score: 866.6 bits: 170.4 E(85289): 1.6e-41
Smith-Waterman score: 2226; 78.2% identity (86.6% similar) in 455 aa overlap (1-454:1-441)
10 20 30 40 50 60
pF1KB3 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
::::::::::::::::::::::::::::::: . ..: .. : . . ..:::
XP_016 LSFKEQELKERERRLKMWEQKLTEQSNTPLL--LPLAARMSEESYFESKT---EESNSAE
310 320 330 340 350
370 380 390 400 410 420
pF1KB3 MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
:: .. .: :. . . .:. : ... : :. ...: . :. ...
XP_016 MS--CQITATSNGEGHGM----NPSLQAMMLMGFGDIFSMNKA-GAVMHSGMQINM--QA
360 370 380 390 400
430 440 450 460 470
pF1KB3 IKDSGGEPEENEEKIVNLELVFG-FHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFN
..:. . . : ::. : :. : :. : .:
XP_016 KQNSSKTTSKRRGKKVNMALGFSDFDLSEGDDDDDDDGEEEDNDMDNSE
410 420 430 440 450
480 490 500 510 520 530
pF1KB3 TNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKP
>>NP_598407 (OMIM: 609479,616890) mitogen-activated prot (455 aa)
initn: 2215 init1: 2215 opt: 2221 Z-score: 866.6 bits: 170.4 E(85289): 1.6e-41
Smith-Waterman score: 2226; 78.2% identity (86.6% similar) in 455 aa overlap (1-454:1-441)
10 20 30 40 50 60
pF1KB3 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_598 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_598 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_598 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_598 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_598 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
::::::::::::::::::::::::::::::: . ..: .. : . . ..:::
NP_598 LSFKEQELKERERRLKMWEQKLTEQSNTPLL--LPLAARMSEESYFESKT---EESNSAE
310 320 330 340 350
370 380 390 400 410 420
pF1KB3 MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
:: .. .: :. . . .:. : ... : :. ...: . :. ...
NP_598 MS--CQITATSNGEGHGM----NPSLQAMMLMGFGDIFSMNKA-GAVMHSGMQINM--QA
360 370 380 390 400
430 440 450 460 470
pF1KB3 IKDSGGEPEENEEKIVNLELVFG-FHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFN
..:. . . : ::. : :. : :. : .:
NP_598 KQNSSKTTSKRRGKKVNMALGFSDFDLSEGDDDDDDDGEEEDNDMDNSE
410 420 430 440 450
480 490 500 510 520 530
pF1KB3 TNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKP
>>XP_005269197 (OMIM: 600447) PREDICTED: mitogen-activat (453 aa)
initn: 492 init1: 358 opt: 739 Z-score: 312.0 bits: 67.8 E(85289): 1.2e-10
Smith-Waterman score: 739; 39.9% identity (70.5% similar) in 308 aa overlap (10-313:152-449)
10 20 30
pF1KB3 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQD
.. :... .. :.:. :.:. ... .
XP_005 EGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRF--HG
130 140 150 160 170
40 50 60 70 80 90
pF1KB3 KEVAVKKLLKIEKEAEI--LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSN
.::::::. . ::..: : :.: ::: : :: . : : :. :. . :.::. . ..
XP_005 EEVAVKKVRDL-KETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG
180 190 200 210 220 230
100 110 120 130 140 150
pF1KB3 RSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-
: .. .. :. .: ::.:::.. :.::::::: :..:. : :.:: :::.:.
XP_005 RPVTPSL--LVDWSMGIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKE
240 250 260 270 280 290
160 170 180 190 200 210
pF1KB3 FHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAW
. ...:.::..:: :::::::.. :::: : .:.::::::.:: :.:.: ... . :
XP_005 LSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW
300 310 320 330 340 350
220 230 240 250 260 270
pF1KB3 LVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDT-SLPDKCNS
: .. .: .::::: .: ::.:::.. ..::::.::. :. : :. : :.. .
XP_005 GVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQE--T
360 370 380 390 400 410
280 290 300 310 320 330
pF1KB3 FLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFE
.....:::: :.. .:..:. : :.:: :.:
XP_005 YFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
420 430 440 450
340 350 360 370 380 390
pF1KB3 IGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKG
>>XP_016875445 (OMIM: 600447) PREDICTED: mitogen-activat (859 aa)
initn: 432 init1: 376 opt: 739 Z-score: 308.6 bits: 68.1 E(85289): 1.9e-10
Smith-Waterman score: 739; 39.9% identity (70.5% similar) in 308 aa overlap (10-313:119-416)
10 20 30
pF1KB3 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQD
.. :... .. :.:. :.:. ... .
XP_016 EGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRF--HG
90 100 110 120 130 140
40 50 60 70 80 90
pF1KB3 KEVAVKKLLKIEKEAEI--LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSN
.::::::. . ::..: : :.: ::: : :: . : : :. :. . :.::. . ..
XP_016 EEVAVKKVRDL-KETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG
150 160 170 180 190 200
100 110 120 130 140 150
pF1KB3 RSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-
: .. .. :. .: ::.:::.. :.::::::: :..:. : :.:: :::.:.
XP_016 RPVTPSL--LVDWSMGIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKE
210 220 230 240 250 260
160 170 180 190 200 210
pF1KB3 FHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAW
. ...:.::..:: :::::::.. :::: : .:.::::::.:: :.:.: ... . :
XP_016 LSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW
270 280 290 300 310 320
220 230 240 250 260 270
pF1KB3 LVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDT-SLPDKCNS
: .. .: .::::: .: ::.:::.. ..::::.::. :. : :. : :.. .
XP_016 GVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQE--T
330 340 350 360 370
280 290 300 310 320 330
pF1KB3 FLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFE
.....:::: :.. .:..:. : :.:: :.:
XP_016 YFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANN
380 390 400 410 420 430
340 350 360 370 380 390
pF1KB3 IGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKG
XP_016 LYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQK
440 450 460 470 480 490
>>NP_006292 (OMIM: 600447) mitogen-activated protein kin (859 aa)
initn: 432 init1: 376 opt: 739 Z-score: 308.6 bits: 68.1 E(85289): 1.9e-10
Smith-Waterman score: 739; 39.9% identity (70.5% similar) in 308 aa overlap (10-313:119-416)
10 20 30
pF1KB3 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQD
.. :... .. :.:. :.:. ... .
NP_006 EGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRF--HG
90 100 110 120 130 140
40 50 60 70 80 90
pF1KB3 KEVAVKKLLKIEKEAEI--LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSN
.::::::. . ::..: : :.: ::: : :: . : : :. :. . :.::. . ..
NP_006 EEVAVKKVRDL-KETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG
150 160 170 180 190 200
100 110 120 130 140 150
pF1KB3 RSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-
: .. .. :. .: ::.:::.. :.::::::: :..:. : :.:: :::.:.
NP_006 RPVTPSL--LVDWSMGIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKE
210 220 230 240 250 260
160 170 180 190 200 210
pF1KB3 FHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAW
. ...:.::..:: :::::::.. :::: : .:.::::::.:: :.:.: ... . :
NP_006 LSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW
270 280 290 300 310 320
220 230 240 250 260 270
pF1KB3 LVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDT-SLPDKCNS
: .. .: .::::: .: ::.:::.. ..::::.::. :. : :. : :.. .
NP_006 GVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQE--T
330 340 350 360 370
280 290 300 310 320 330
pF1KB3 FLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFE
.....:::: :.. .:..:. : :.:: :.:
NP_006 YFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANN
380 390 400 410 420 430
340 350 360 370 380 390
pF1KB3 IGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKG
NP_006 LYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQK
440 450 460 470 480 490
>>NP_001180440 (OMIM: 600447) mitogen-activated protein (892 aa)
initn: 404 init1: 376 opt: 739 Z-score: 308.4 bits: 68.1 E(85289): 1.9e-10
Smith-Waterman score: 739; 39.9% identity (70.5% similar) in 308 aa overlap (10-313:152-449)
10 20 30
pF1KB3 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQD
.. :... .. :.:. :.:. ... .
NP_001 EGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRF--HG
130 140 150 160 170
40 50 60 70 80 90
pF1KB3 KEVAVKKLLKIEKEAEI--LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSN
.::::::. . ::..: : :.: ::: : :: . : : :. :. . :.::. . ..
NP_001 EEVAVKKVRDL-KETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG
180 190 200 210 220 230
100 110 120 130 140 150
pF1KB3 RSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-
: .. .. :. .: ::.:::.. :.::::::: :..:. : :.:: :::.:.
NP_001 RPVTPSL--LVDWSMGIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKE
240 250 260 270 280 290
160 170 180 190 200 210
pF1KB3 FHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAW
. ...:.::..:: :::::::.. :::: : .:.::::::.:: :.:.: ... . :
NP_001 LSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW
300 310 320 330 340 350
220 230 240 250 260 270
pF1KB3 LVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDT-SLPDKCNS
: .. .: .::::: .: ::.:::.. ..::::.::. :. : :. : :.. .
NP_001 GVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQE--T
360 370 380 390 400 410
280 290 300 310 320 330
pF1KB3 FLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFE
.....:::: :.. .:..:. : :.:: :.:
NP_001 YFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANN
420 430 440 450 460 470
340 350 360 370 380 390
pF1KB3 IGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKG
NP_001 LYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQK
480 490 500 510 520 530
>>XP_005269195 (OMIM: 600447) PREDICTED: mitogen-activat (892 aa)
initn: 404 init1: 376 opt: 739 Z-score: 308.4 bits: 68.1 E(85289): 1.9e-10
Smith-Waterman score: 739; 39.9% identity (70.5% similar) in 308 aa overlap (10-313:152-449)
10 20 30
pF1KB3 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQD
.. :... .. :.:. :.:. ... .
XP_005 EGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRF--HG
130 140 150 160 170
40 50 60 70 80 90
pF1KB3 KEVAVKKLLKIEKEAEI--LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSN
.::::::. . ::..: : :.: ::: : :: . : : :. :. . :.::. . ..
XP_005 EEVAVKKVRDL-KETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG
180 190 200 210 220 230
100 110 120 130 140 150
pF1KB3 RSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-
: .. .. :. .: ::.:::.. :.::::::: :..:. : :.:: :::.:.
XP_005 RPVTPSL--LVDWSMGIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKE
240 250 260 270 280 290
160 170 180 190 200 210
pF1KB3 FHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAW
. ...:.::..:: :::::::.. :::: : .:.::::::.:: :.:.: ... . :
XP_005 LSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW
300 310 320 330 340 350
220 230 240 250 260 270
pF1KB3 LVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDT-SLPDKCNS
: .. .: .::::: .: ::.:::.. ..::::.::. :. : :. : :.. .
XP_005 GVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQE--T
360 370 380 390 400 410
280 290 300 310 320 330
pF1KB3 FLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFE
.....:::: :.. .:..:. : :.:: :.:
XP_005 YFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANN
420 430 440 450 460 470
340 350 360 370 380 390
pF1KB3 IGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKG
XP_005 LYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQK
480 490 500 510 520 530
800 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:15:56 2016 done: Thu Nov 3 13:15:58 2016
Total Scan time: 13.340 Total Display time: 0.130
Function used was FASTA [36.3.4 Apr, 2011]