Result of FASTA (omim) for
pFN21AB3349
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3349, 1527 aa
1>>>pF1KB3349 1527 - 1527 aa - 1527 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6950+/-0.00051; mu= 21.9193+/- 0.031
mean_var=88.4816+/-18.014, 0's: 0 Z-trim(108.9): 232 B-trim: 196 in 2/49
Lambda= 0.136348
statistics sampled from 16714 (16991) to 16714 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.531), E-opt: 0.2 (0.199), width: 16
Scan time: 15.950
The best scores are: opt bits E(85289)
NP_003777 (OMIM: 604323) canalicular multispecific (1527) 10037 1986.1 0
XP_011523726 (OMIM: 604323) PREDICTED: canalicular (1302) 8462 1676.3 0
XP_005257820 (OMIM: 604323) PREDICTED: canalicular (1463) 7756 1537.4 0
XP_011523727 (OMIM: 604323) PREDICTED: canalicular (1285) 7008 1390.3 0
XP_016880754 (OMIM: 604323) PREDICTED: canalicular (1285) 7008 1390.3 0
XP_011523724 (OMIM: 604323) PREDICTED: canalicular (1498) 7008 1390.3 0
XP_011523725 (OMIM: 604323) PREDICTED: canalicular (1562) 7008 1390.3 0
XP_016880755 (OMIM: 604323) PREDICTED: canalicular (1271) 5091 1013.2 0
XP_006717693 (OMIM: 237500,601107) PREDICTED: cana (1313) 4132 824.5 0
NP_000383 (OMIM: 237500,601107) canalicular multis (1545) 4132 824.6 0
NP_001137542 (OMIM: 604323) canalicular multispeci ( 572) 3682 735.8 2.4e-211
NP_004987 (OMIM: 158343) multidrug resistance-asso (1531) 3324 665.6 8.3e-190
XP_016878726 (OMIM: 158343) PREDICTED: multidrug r (1549) 3306 662.1 9.8e-189
XP_011520799 (OMIM: 158343) PREDICTED: multidrug r (1523) 3303 661.5 1.5e-188
XP_016878728 (OMIM: 158343) PREDICTED: multidrug r (1503) 2748 552.3 1.1e-155
XP_016878727 (OMIM: 158343) PREDICTED: multidrug r (1507) 2628 528.7 1.3e-148
XP_016878730 (OMIM: 158343) PREDICTED: multidrug r (1461) 2605 524.2 3e-147
XP_016878731 (OMIM: 158343) PREDICTED: multidrug r (1434) 2475 498.6 1.5e-139
XP_016878729 (OMIM: 158343) PREDICTED: multidrug r (1490) 2475 498.6 1.5e-139
XP_011520800 (OMIM: 158343) PREDICTED: multidrug r (1500) 2475 498.6 1.5e-139
XP_016878732 (OMIM: 158343) PREDICTED: multidrug r ( 931) 2410 485.7 7.5e-136
XP_011520784 (OMIM: 177850,264800,603234,614473) P ( 887) 2354 474.7 1.5e-132
XP_016878703 (OMIM: 177850,264800,603234,614473) P (1166) 2353 474.6 2.1e-132
XP_016871164 (OMIM: 237500,601107) PREDICTED: cana ( 892) 2034 411.7 1.3e-113
XP_006717694 (OMIM: 237500,601107) PREDICTED: cana ( 895) 2033 411.5 1.5e-113
XP_011537593 (OMIM: 237500,601107) PREDICTED: cana ( 916) 2030 410.9 2.3e-113
XP_005253346 (OMIM: 239850,601439,608569,614050) P (1536) 1869 379.4 1.2e-103
XP_006719088 (OMIM: 239850,601439,608569,614050) P (1536) 1866 378.8 1.8e-103
XP_016866941 (OMIM: 612509) PREDICTED: multidrug r (1339) 1777 361.3 3e-98
NP_258261 (OMIM: 612509) multidrug resistance-asso (1464) 1777 361.3 3.2e-98
XP_016866935 (OMIM: 612509) PREDICTED: multidrug r (1507) 1777 361.3 3.3e-98
XP_016866936 (OMIM: 612509) PREDICTED: multidrug r (1507) 1777 361.3 3.3e-98
XP_016866934 (OMIM: 612509) PREDICTED: multidrug r (1558) 1777 361.3 3.4e-98
XP_011520783 (OMIM: 177850,264800,603234,614473) P (1389) 1734 352.9 1.1e-95
XP_011520782 (OMIM: 177850,264800,603234,614473) P (1389) 1734 352.9 1.1e-95
XP_016878702 (OMIM: 177850,264800,603234,614473) P (1389) 1734 352.9 1.1e-95
XP_016878701 (OMIM: 177850,264800,603234,614473) P (1447) 1734 352.9 1.1e-95
XP_011520781 (OMIM: 177850,264800,603234,614473) P (1492) 1734 352.9 1.2e-95
NP_001162 (OMIM: 177850,264800,603234,614473) mult (1503) 1734 352.9 1.2e-95
XP_016866938 (OMIM: 612509) PREDICTED: multidrug r (1501) 1547 316.1 1.4e-84
XP_016866937 (OMIM: 612509) PREDICTED: multidrug r (1501) 1547 316.1 1.4e-84
XP_016879288 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
XP_016879285 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
XP_016879284 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
XP_016879287 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
XP_016879286 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
XP_016879289 (OMIM: 117800,607040) PREDICTED: ATP- (1382) 1492 305.2 2.3e-81
NP_115972 (OMIM: 117800,607040) ATP-binding casset (1382) 1492 305.2 2.3e-81
NP_149163 (OMIM: 117800,607040) ATP-binding casset (1382) 1492 305.2 2.3e-81
XP_016866943 (OMIM: 612509) PREDICTED: multidrug r (1063) 1471 301.0 3.3e-80
>>NP_003777 (OMIM: 604323) canalicular multispecific org (1527 aa)
initn: 10037 init1: 10037 opt: 10037 Z-score: 10665.2 bits: 1986.1 E(85289): 0
Smith-Waterman score: 10037; 99.9% identity (99.9% similar) in 1527 aa overlap (1-1527:1-1527)
10 20 30 40 50 60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 LQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
NP_003 LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB3 SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB3 FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB3 KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB3 IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB3 RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB3 LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
1450 1460 1470 1480 1490 1500
1510 1520
pF1KB3 VAEFDSPANLIAARGIFYGMARDAGLA
:::::::::::::::::::::::::::
NP_003 VAEFDSPANLIAARGIFYGMARDAGLA
1510 1520
>>XP_011523726 (OMIM: 604323) PREDICTED: canalicular mul (1302 aa)
initn: 8462 init1: 8462 opt: 8462 Z-score: 8991.8 bits: 1676.3 E(85289): 0
Smith-Waterman score: 8462; 99.9% identity (99.9% similar) in 1302 aa overlap (226-1527:1-1302)
200 210 220 230 240 250
pF1KB3 FFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQ
::::::::::::::::::::::::::::::
XP_011 MAIYGYRHPLEEKDLWSLKEEDRSQMVVQQ
10 20 30
260 270 280 290 300 310
pF1KB3 LLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISA
40 50 60 70 80 90
320 330 340 350 360 370
pF1KB3 CFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIF
100 110 120 130 140 150
380 390 400 410 420 430
pF1KB3 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL
160 170 180 190 200 210
440 450 460 470 480 490
pF1KB3 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL
220 230 240 250 260 270
500 510 520 530 540 550
pF1KB3 NGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV
280 290 300 310 320 330
560 570 580 590 600 610
pF1KB3 YVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS
340 350 360 370 380 390
620 630 640 650 660 670
pF1KB3 VERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALL
400 410 420 430 440 450
680 690 700 710 720 730
pF1KB3 GEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEM
460 470 480 490 500 510
740 750 760 770 780 790
pF1KB3 LPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIG
520 530 540 550 560 570
800 810 820 830 840 850
pF1KB3 PEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPD
580 590 600 610 620 630
860 870 880 890 900 910
pF1KB3 EDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGE
640 650 660 670 680 690
920 930 940 950 960 970
pF1KB3 GQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAIC
700 710 720 730 740 750
980 990 1000 1010 1020 1030
pF1KB3 LLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAA
760 770 780 790 800 810
1040 1050 1060 1070 1080 1090
pF1KB3 GGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFF
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFF
820 830 840 850 860 870
1100 1110 1120 1130 1140 1150
pF1KB3 NAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETV
880 890 900 910 920 930
1160 1170 1180 1190 1200 1210
pF1KB3 TGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAV
940 950 960 970 980 990
1220 1230 1240 1250 1260 1270
pF1KB3 IGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVE
1000 1010 1020 1030 1040 1050
1280 1290 1300 1310 1320 1330
pF1KB3 GSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLC
1060 1070 1080 1090 1100 1110
1340 1350 1360 1370 1380 1390
pF1KB3 LFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDI
1120 1130 1140 1150 1160 1170
1400 1410 1420 1430 1440 1450
pF1KB3 WWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAA
1180 1190 1200 1210 1220 1230
1460 1470 1480 1490 1500 1510
pF1KB3 IDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARG
1240 1250 1260 1270 1280 1290
1520
pF1KB3 IFYGMARDAGLA
::::::::::::
XP_011 IFYGMARDAGLA
1300
>>XP_005257820 (OMIM: 604323) PREDICTED: canalicular mul (1463 aa)
initn: 7756 init1: 7756 opt: 7756 Z-score: 8240.5 bits: 1537.4 E(85289): 0
Smith-Waterman score: 9487; 95.7% identity (95.7% similar) in 1527 aa overlap (1-1527:1-1463)
10 20 30 40 50 60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
:::::::::::::::::::::::::::::
XP_005 WSLKEEDRSQMVVQQLLEAWRKQEKQTAR-------------------------------
250 260
310 320 330 340 350 360
pF1KB3 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
:::::::::::::::::::::::::::
XP_005 ---------------------------------ILIRFISNPMAPSWWGFLVAGLMFLCS
270 280 290
370 380 390 400 410 420
pF1KB3 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
300 310 320 330 340 350
430 440 450 460 470 480
pF1KB3 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
360 370 380 390 400 410
490 500 510 520 530 540
pF1KB3 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
420 430 440 450 460 470
550 560 570 580 590 600
pF1KB3 CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
480 490 500 510 520 530
610 620 630 640 650 660
pF1KB3 RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
540 550 560 570 580 590
670 680 690 700 710 720
pF1KB3 GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
600 610 620 630 640 650
730 740 750 760 770 780
pF1KB3 QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
660 670 680 690 700 710
790 800 810 820 830 840
pF1KB3 VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
720 730 740 750 760 770
850 860 870 880 890 900
pF1KB3 RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
780 790 800 810 820 830
910 920 930 940 950 960
pF1KB3 KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
840 850 860 870 880 890
970 980 990 1000 1010 1020
pF1KB3 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
900 910 920 930 940 950
1030 1040 1050 1060 1070 1080
pF1KB3 LQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_005 LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
960 970 980 990 1000 1010
1090 1100 1110 1120 1130 1140
pF1KB3 EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
1020 1030 1040 1050 1060 1070
1150 1160 1170 1180 1190 1200
pF1KB3 SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
1080 1090 1100 1110 1120 1130
1210 1220 1230 1240 1250 1260
pF1KB3 FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
1140 1150 1160 1170 1180 1190
1270 1280 1290 1300 1310 1320
pF1KB3 KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
1200 1210 1220 1230 1240 1250
1330 1340 1350 1360 1370 1380
pF1KB3 IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
1260 1270 1280 1290 1300 1310
1390 1400 1410 1420 1430 1440
pF1KB3 RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
1320 1330 1340 1350 1360 1370
1450 1460 1470 1480 1490 1500
pF1KB3 LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
1380 1390 1400 1410 1420 1430
1510 1520
pF1KB3 VAEFDSPANLIAARGIFYGMARDAGLA
:::::::::::::::::::::::::::
XP_005 VAEFDSPANLIAARGIFYGMARDAGLA
1440 1450 1460
>>XP_011523727 (OMIM: 604323) PREDICTED: canalicular mul (1285 aa)
initn: 7008 init1: 7008 opt: 7008 Z-score: 7446.1 bits: 1390.3 E(85289): 0
Smith-Waterman score: 7008; 99.9% identity (99.9% similar) in 1082 aa overlap (446-1527:204-1285)
420 430 440 450 460 470
pF1KB3 DAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRA
::::::::::::::::::::::::::::::
XP_011 STPADHPGDLLPLADFGNLSLCVIYPPVPPQNLGPSVLAGVAFMVLLIPLNGAVAVKMRA
180 190 200 210 220 230
480 490 500 510 520 530
pF1KB3 FQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTT
240 250 260 270 280 290
540 550 560 570 580 590
pF1KB3 TFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQA
300 310 320 330 340 350
600 610 620 630 640 650
pF1KB3 SVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGA
360 370 380 390 400 410
660 670 680 690 700 710
pF1KB3 LVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKAL
420 430 440 450 460 470
720 730 740 750 760 770
pF1KB3 NPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLD
480 490 500 510 520 530
780 790 800 810 820 830
pF1KB3 DPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPY
540 550 560 570 580 590
840 850 860 870 880 890
pF1KB3 PALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPV
600 610 620 630 640 650
900 910 920 930 940 950
pF1KB3 TYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVE
660 670 680 690 700 710
960 970 980 990 1000 1010
pF1KB3 LSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVY
720 730 740 750 760 770
1020 1030 1040 1050 1060 1070
pF1KB3 AALGILQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKD
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_011 AALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKD
780 790 800 810 820 830
1080 1090 1100 1110 1120 1130
pF1KB3 IYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQ
840 850 860 870 880 890
1140 1150 1160 1170 1180 1190
pF1KB3 LKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWL
900 910 920 930 940 950
1200 1210 1220 1230 1240 1250
pF1KB3 SIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIV
960 970 980 990 1000 1010
1260 1270 1280 1290 1300 1310
pF1KB3 AVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHG
1020 1030 1040 1050 1060 1070
1320 1330 1340 1350 1360 1370
pF1KB3 GEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPIL
1080 1090 1100 1110 1120 1130
1380 1390 1400 1410 1420 1430
pF1KB3 FSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVC
1140 1150 1160 1170 1180 1190
1440 1450 1460 1470 1480 1490
pF1KB3 LARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLV
1200 1210 1220 1230 1240 1250
1500 1510 1520
pF1KB3 LDKGVVAEFDSPANLIAARGIFYGMARDAGLA
::::::::::::::::::::::::::::::::
XP_011 LDKGVVAEFDSPANLIAARGIFYGMARDAGLA
1260 1270 1280
>>XP_016880754 (OMIM: 604323) PREDICTED: canalicular mul (1285 aa)
initn: 7008 init1: 7008 opt: 7008 Z-score: 7446.1 bits: 1390.3 E(85289): 0
Smith-Waterman score: 7008; 99.9% identity (99.9% similar) in 1082 aa overlap (446-1527:204-1285)
420 430 440 450 460 470
pF1KB3 DAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRA
::::::::::::::::::::::::::::::
XP_016 STPADHPGDLLPLADFGNLSLCVIYPPVPPQNLGPSVLAGVAFMVLLIPLNGAVAVKMRA
180 190 200 210 220 230
480 490 500 510 520 530
pF1KB3 FQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTT
240 250 260 270 280 290
540 550 560 570 580 590
pF1KB3 TFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQA
300 310 320 330 340 350
600 610 620 630 640 650
pF1KB3 SVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGA
360 370 380 390 400 410
660 670 680 690 700 710
pF1KB3 LVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKAL
420 430 440 450 460 470
720 730 740 750 760 770
pF1KB3 NPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLD
480 490 500 510 520 530
780 790 800 810 820 830
pF1KB3 DPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPY
540 550 560 570 580 590
840 850 860 870 880 890
pF1KB3 PALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPV
600 610 620 630 640 650
900 910 920 930 940 950
pF1KB3 TYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVE
660 670 680 690 700 710
960 970 980 990 1000 1010
pF1KB3 LSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVY
720 730 740 750 760 770
1020 1030 1040 1050 1060 1070
pF1KB3 AALGILQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKD
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_016 AALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKD
780 790 800 810 820 830
1080 1090 1100 1110 1120 1130
pF1KB3 IYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQ
840 850 860 870 880 890
1140 1150 1160 1170 1180 1190
pF1KB3 LKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWL
900 910 920 930 940 950
1200 1210 1220 1230 1240 1250
pF1KB3 SIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIV
960 970 980 990 1000 1010
1260 1270 1280 1290 1300 1310
pF1KB3 AVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHG
1020 1030 1040 1050 1060 1070
1320 1330 1340 1350 1360 1370
pF1KB3 GEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPIL
1080 1090 1100 1110 1120 1130
1380 1390 1400 1410 1420 1430
pF1KB3 FSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVC
1140 1150 1160 1170 1180 1190
1440 1450 1460 1470 1480 1490
pF1KB3 LARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLV
1200 1210 1220 1230 1240 1250
1500 1510 1520
pF1KB3 LDKGVVAEFDSPANLIAARGIFYGMARDAGLA
::::::::::::::::::::::::::::::::
XP_016 LDKGVVAEFDSPANLIAARGIFYGMARDAGLA
1260 1270 1280
>>XP_011523724 (OMIM: 604323) PREDICTED: canalicular mul (1498 aa)
initn: 8572 init1: 7008 opt: 7008 Z-score: 7445.2 bits: 1390.3 E(85289): 0
Smith-Waterman score: 8503; 87.2% identity (90.5% similar) in 1540 aa overlap (1-1527:1-1498)
10 20 30 40 50 60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
130 140 150 160 170 180
190 200 210 220 230
pF1KB3 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKM--------AIYGYR
:::::::::::::::::::::::::::::::::::::::::::::. . :.
XP_011 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKLLNPDPLRGCLPGFT
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB3 HPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARP
: .. :: .: : . : :.:: : . .:. . :..:
XP_011 SP-QDGHLWLPASPGGEGPLVP-------KGRGQIPDGGAAAAGGMEEAGKAD---GTHP
250 260 270 280
300 310 320 330 340
pF1KB3 -----RPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSW
.:. : :.. :. . . . :: ... :.
XP_011 DQVYLQPHGP----LLVGLPGGWADVPVLHDAVADLTTLL--------------PLHLCD
290 300 310 320 330
350 360 370 380 390 400
pF1KB3 WGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVG
:: :. : .... .. . : . . . : :: . ....:
XP_011 WGE-VSYWDHGCHLQEGSGYHQLSQTCVHCGGNCQPHVSGC---PALHGPCPLPQSAVV-
340 350 360 370 380
410 420 430 440 450 460
pF1KB3 EIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNG
:. :.. :: :. .. . : .: ::::::::::::::::::::::
XP_011 ------STPADHPGDLLPLADF-GNLSLCVIYPPVPP-QNLGPSVLAGVAFMVLLIPLNG
390 400 410 420 430
470 480 490 500 510 520
pF1KB3 AVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRT
440 450 460 470 480 490
530 540 550 560 570 580
pF1KB3 AAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQ
500 510 520 530 540 550
590 600 610 620 630 640
pF1KB3 LISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSL
560 570 580 590 600 610
650 660 670 680 690 700
pF1KB3 DIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQE
620 630 640 650 660 670
710 720 730 740 750 760
pF1KB3 NVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYS
680 690 700 710 720 730
770 780 790 800 810 820
pF1KB3 DADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADG
740 750 760 770 780 790
830 840 850 860 870 880
pF1KB3 QVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHT
800 810 820 830 840 850
890 900 910 920 930 940
pF1KB3 DLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEE
860 870 880 890 900 910
950 960 970 980 990 1000
pF1KB3 KAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNN
920 930 940 950 960 970
1010 1020 1030 1040 1050 1060
pF1KB3 TSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGR
::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
XP_011 TSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGR
980 990 1000 1010 1020 1030
1070 1080 1090 1100 1110 1120
pF1KB3 ILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQR
1040 1050 1060 1070 1080 1090
1130 1140 1150 1160 1170 1180
pF1KB3 FYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYP
1100 1110 1120 1130 1140 1150
1190 1200 1210 1220 1230 1240
pF1KB3 YIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMM
1160 1170 1180 1190 1200 1210
1250 1260 1270 1280 1290 1300
pF1KB3 SDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLR
1220 1230 1240 1250 1260 1270
1310 1320 1330 1340 1350 1360
pF1KB3 DLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLT
1280 1290 1300 1310 1320 1330
1370 1380 1390 1400 1410 1420
pF1KB3 IIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLS
1340 1350 1360 1370 1380 1390
1430 1440 1450 1460 1470 1480
pF1KB3 VGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTI
1400 1410 1420 1430 1440 1450
1490 1500 1510 1520
pF1KB3 MDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGLA
::::::::::::::::::::::::::::::::::::::::
XP_011 MDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGLA
1460 1470 1480 1490
>>XP_011523725 (OMIM: 604323) PREDICTED: canalicular mul (1562 aa)
initn: 8572 init1: 7008 opt: 7008 Z-score: 7445.0 bits: 1390.3 E(85289): 0
Smith-Waterman score: 8466; 86.1% identity (90.0% similar) in 1564 aa overlap (4-1527:4-1562)
10 20 30 40 50 60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
130 140 150 160 170 180
190 200 210 220 230
pF1KB3 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKM--------AIYGYR
:::::::::::::::::::::::::::::::::::::::::::::. . :.
XP_011 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKLLNPDPLRGCLPGFT
190 200 210 220 230 240
240 250 260 270
pF1KB3 HPLEEKDLW---------SLKEEDRSQM-----VVQQLLEAWRKQEKQTARHKASAAP--
: .. :: : . :.:. .. .: : . : ...
XP_011 SP-QDGHLWLPASPGGEGPLVPKGRGQIPDGGAAAAGGMEEAGKADGTTQGFSSTWEKCL
250 260 270 280 290
280 290 300 310 320
pF1KB3 --GKNASG----EDEVLLGARP----RPRKPSFLKALLATFGSSFLI---SACFKLIQDL
:..:.: :.:: : : . : . :: .. . :. .: . :
XP_011 RRGRGAAGCPAQAPEALLPEGPAGHLRLQLPH--QCLLQAYPGPALLHQSTAAQHPDQVY
300 310 320 330 340 350
330 340 350 360 370 380
pF1KB3 LSFINPQLLSILIRFISNPMAPSWWGFLVAGL-MFLCSMMQSLILQHYYHYIFVTGVK--
:. .: :... . . :. . . :.. : . ::. . .: : .: .
XP_011 LQPHGPLLVGLPGGWADVPVLHDAVADLTTLLPLHLCDWGEVSYWDHGCHLQEGSGYHQL
360 370 380 390 400 410
390 400 410 420 430 440
pF1KB3 FRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILA
.: . . : . .. ..:. :.. :: :. .. . : .:
XP_011 SQTCVHCGGNCQPHVSGCPALHGPCPLPQSAVVSTPADHPGDLLPLADF-GNLSLCVIYP
420 430 440 450 460 470
450 460 470 480 490 500
pF1KB3 IYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVPP-QNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKV
480 490 500 510 520 530
510 520 530 540 550 560
pF1KB3 LKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPN
540 550 560 570 580 590
570 580 590 600 610 620
pF1KB3 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT
600 610 620 630 640 650
630 640 650 660 670 680
pF1KB3 ISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEK
660 670 680 690 700 710
690 700 710 720 730 740
pF1KB3 LEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGD
720 730 740 750 760 770
750 760 770 780 790 800
pF1KB3 QTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVL
780 790 800 810 820 830
810 820 830 840 850 860
pF1KB3 AGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGH
840 850 860 870 880 890
870 880 890 900 910 920
pF1KB3 LEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRP
900 910 920 930 940 950
930 940 950 960 970 980
pF1KB3 VPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVG
960 970 980 990 1000 1010
990 1000 1010 1020 1030 1040
pF1KB3 QSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQA
1020 1030 1040 1050 1060 1070
1050 1060 1070 1080 1090 1100
pF1KB3 ARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAIST
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAIST
1080 1090 1100 1110 1120 1130
1110 1120 1130 1140 1150 1160
pF1KB3 LVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASV
1140 1150 1160 1170 1180 1190
1170 1180 1190 1200 1210 1220
pF1KB3 IRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSS
1200 1210 1220 1230 1240 1250
1230 1240 1250 1260 1270 1280
pF1KB3 LNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPP
1260 1270 1280 1290 1300 1310
1290 1300 1310 1320 1330 1340
pF1KB3 EGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRIL
1320 1330 1340 1350 1360 1370
1350 1360 1370 1380 1390 1400
pF1KB3 EAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALE
1380 1390 1400 1410 1420 1430
1410 1420 1430 1440 1450 1460
pF1KB3 LSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLET
1440 1450 1460 1470 1480 1490
1470 1480 1490 1500 1510 1520
pF1KB3 DNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGM
1500 1510 1520 1530 1540 1550
pF1KB3 ARDAGLA
:::::::
XP_011 ARDAGLA
1560
>>XP_016880755 (OMIM: 604323) PREDICTED: canalicular mul (1271 aa)
initn: 6655 init1: 5091 opt: 5091 Z-score: 5408.2 bits: 1013.2 E(85289): 0
Smith-Waterman score: 6549; 82.9% identity (87.7% similar) in 1272 aa overlap (4-1235:4-1270)
10 20 30 40 50 60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
130 140 150 160 170 180
190 200 210 220 230
pF1KB3 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKM--------AIYGYR
:::::::::::::::::::::::::::::::::::::::::::::. . :.
XP_016 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKLLNPDPLRGCLPGFT
190 200 210 220 230 240
240 250 260 270
pF1KB3 HPLEEKDLW---------SLKEEDRSQM-----VVQQLLEAWRKQEKQTARHKASAAP--
: .. :: : . :.:. .. .: : . : ...
XP_016 SP-QDGHLWLPASPGGEGPLVPKGRGQIPDGGAAAAGGMEEAGKADGTTQGFSSTWEKCL
250 260 270 280 290
280 290 300 310 320
pF1KB3 --GKNASG----EDEVLLGARP----RPRKPSFLKALLATFGSSFLI---SACFKLIQDL
:..:.: :.:: : : . : . :: .. . :. .: . :
XP_016 RRGRGAAGCPAQAPEALLPEGPAGHLRLQLPH--QCLLQAYPGPALLHQSTAAQHPDQVY
300 310 320 330 340 350
330 340 350 360 370 380
pF1KB3 LSFINPQLLSILIRFISNPMAPSWWGFLVAGL-MFLCSMMQSLILQHYYHYIFVTGVK--
:. .: :... . . :. . . :.. : . ::. . .: : .: .
XP_016 LQPHGPLLVGLPGGWADVPVLHDAVADLTTLLPLHLCDWGEVSYWDHGCHLQEGSGYHQL
360 370 380 390 400 410
390 400 410 420 430 440
pF1KB3 FRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILA
.: . . : . .. ..:. :.. :: :. .. . : .:
XP_016 SQTCVHCGGNCQPHVSGCPALHGPCPLPQSAVVSTPADHPGDLLPLADF-GNLSLCVIYP
420 430 440 450 460 470
450 460 470 480 490 500
pF1KB3 IYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVPP-QNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKV
480 490 500 510 520 530
510 520 530 540 550 560
pF1KB3 LKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPN
540 550 560 570 580 590
570 580 590 600 610 620
pF1KB3 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT
600 610 620 630 640 650
630 640 650 660 670 680
pF1KB3 ISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEK
660 670 680 690 700 710
690 700 710 720 730 740
pF1KB3 LEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGD
720 730 740 750 760 770
750 760 770 780 790 800
pF1KB3 QTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVL
780 790 800 810 820 830
810 820 830 840 850 860
pF1KB3 AGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGH
840 850 860 870 880 890
870 880 890 900 910 920
pF1KB3 LEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRP
900 910 920 930 940 950
930 940 950 960 970 980
pF1KB3 VPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVG
960 970 980 990 1000 1010
990 1000 1010 1020 1030 1040
pF1KB3 QSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQA
1020 1030 1040 1050 1060 1070
1050 1060 1070 1080 1090 1100
pF1KB3 ARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAIST
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAIST
1080 1090 1100 1110 1120 1130
1110 1120 1130 1140 1150 1160
pF1KB3 LVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASV
1140 1150 1160 1170 1180 1190
1170 1180 1190 1200 1210 1220
pF1KB3 IRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSS
1200 1210 1220 1230 1240 1250
1230 1240 1250 1260 1270 1280
pF1KB3 LNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPP
:::::::::::::::
XP_016 LNPGLVGLSVSYSLQT
1260 1270
>>XP_006717693 (OMIM: 237500,601107) PREDICTED: canalicu (1313 aa)
initn: 3477 init1: 1549 opt: 4132 Z-score: 4388.5 bits: 824.5 E(85289): 0
Smith-Waterman score: 4162; 49.8% identity (78.0% similar) in 1320 aa overlap (235-1526:1-1305)
210 220 230 240 250 260
pF1KB3 NPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEA-WRKQ
.. : : : : : . . .:. .: :.:
XP_006 MKTKTLVS-KFETHMKRELQKARRALQRRQ
10 20
270 280 290 300 310
pF1KB3 EKQTARHKASAAPG--KNAS-GEDEVLLGARPRPRKPS----------FLKALLATFGSS
::.. ..... :: :: : ..: ..: . .: : ..:::. ::
XP_006 EKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMV
30 40 50 60 70 80
320 330 340 350 360 370
pF1KB3 FLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHY
.: : .::..:...:..::::..:: : :. . : :.: : :.: ...::. :: :
XP_006 LLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCY
90 100 110 120 130 140
380 390 400 410 420 430
pF1KB3 YHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLL
.. : ::: ::.::. .:.:::...: ... :::: :::::::::..::.. :...:
XP_006 FQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHML
150 160 170 180 190 200
440 450 460 470 480 490
pF1KB3 WSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKL
::. :::.:.:.:::..:::::::::. :::.::.:. ...: ...:::.:: ::.:.:.
XP_006 WSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKI
210 220 230 240 250 260
500 510 520 530 540 550
pF1KB3 MSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLIT
:.:::.:::.:: .:::::: ::...:. ::. : . . :. .. :... .: ::...:
XP_006 MNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVT
270 280 290 300 310 320
560 570 580 590 600 610
pF1KB3 LWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEE
. ::: :: ::.:::.:::.:..::::::.::.:::..::.. ::::: .:....:. ..
XP_006 FSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDD
330 340 350 360 370 380
620 630 640 650 660 670
pF1KB3 LDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSL
:: ... :. . :. . ..::: .: :........ : ::::.:::: :::::
XP_006 LDTSAI-RHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSL
390 400 410 420 430 440
680 690 700 710 720 730
pF1KB3 VSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALL
.::.:::::...:.. .::..::::::.:::: :...:.::: .: :::::.:::::::
XP_006 ISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALL
450 460 470 480 490 500
740 750 760 770 780 790
pF1KB3 ADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIF
::::::::: .:::::::::::::.::.:::::.:.. ::.::::::::::.::.::::
XP_006 PDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIF
510 520 530 540 550 560
800 810 820 830 840
pF1KB3 DHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFAN---
..:.::.:.: ::::.::::.. ::::.: :.::..: . : : : ::: ..: ::.
XP_006 NKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLK
570 580 590 600 610 620
850 860 870 880 890 900
pF1KB3 -FLCNYAPDEDQGHLEDSWTALEGAEDKEALLIED--TLSNHTDLT-DNDPVTYVVQKQF
:: . .:.:. :. .:.:... .: .:. .. : .:. ...:
XP_006 TFLRHTGPEEEA-------TVHDGSEEED----DDYGLISSVEEIPEDAASITMRRENSF
630 640 650 660 670
910 920 930 940 950 960
pF1KB3 MRQLSALSSDGEGQGRPVPRRHLGPSE--KVQVTEAKADGA-LTQEEKAAIGTVELSVFW
: :: :: ..:. : : . ... : . : : ..: : :..:..
XP_006 RRTLSR-SSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYL
680 690 700 710 720 730
970 980 990 1000 1010
pF1KB3 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAM----ADSRQNNTSLRLGVYA
.: .:.:: . . : : .: .:.: ::.:.::::::.:. .: .. ..:.:::.
XP_006 EYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYG
740 750 760 770 780 790
1020 1030 1040 1050 1060 1070
pF1KB3 ALGILQGFLVMLAAMAMAAGGIQAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDI
:::. ::..:..: . : : ..:. .::. : .: .:.:. ::::::.:::.: :. ::
XP_006 ALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDI
800 810 820 830 840 850
1080 1090 1100 1110 1120 1130
pF1KB3 YVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQL
.::..: . .. :.. :::::.: .::.::....::...:. :: ::..:::::
XP_006 STVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQL
860 870 880 890 900 910
1140 1150 1160 1170 1180 1190
pF1KB3 KRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLS
.::.::.::::::::::::.: ::::..... : .....:.::. . .: :::::.
XP_006 RRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLA
920 930 940 950 960 970
1200 1210 1220 1230 1240 1250
pF1KB3 IGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVA
: .:.::: .:.:.::. :: :..:. ::. .: .:..: .:::..:: :..:.::::
XP_006 IRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVA
980 990 1000 1010 1020 1030
1260 1270 1280 1290 1300 1310
pF1KB3 VERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGG
:::. ::.:.:.:::::.. .::: :: .:...: ::.::::: :::::: .. . .
XP_006 VERITEYTKVENEAPWVTD-KRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSM
1040 1050 1060 1070 1080 1090
1320 1330 1340 1350 1360 1370
pF1KB3 EKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILF
::.:.::::::::::.: ::::::::: :.: :::...:.::::::: .:::::::::::
XP_006 EKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILF
1100 1110 1120 1130 1140 1150
1380 1390 1400 1410 1420 1430
pF1KB3 SGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCL
::.::::::::..::.:.:: ::::.::..::.: ::. . .:.: :::.:::::.::
XP_006 SGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCL
1160 1170 1180 1190 1200 1210
1440 1450 1460 1470 1480 1490
pF1KB3 ARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVL
.:::::::.::::::::::.:::::::::.::...: :::.::::::.:::: .:.::
XP_006 GRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVL
1220 1230 1240 1250 1260 1270
1500 1510 1520
pF1KB3 DKGVVAEFDSPANLIAARGIFYGMARDAGLA
:.: . : :: .:. : :: ::..::.
XP_006 DNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF
1280 1290 1300 1310
>>NP_000383 (OMIM: 237500,601107) canalicular multispeci (1545 aa)
initn: 3700 init1: 1549 opt: 4132 Z-score: 4387.5 bits: 824.6 E(85289): 0
Smith-Waterman score: 4452; 46.2% identity (74.8% similar) in 1557 aa overlap (12-1526:8-1537)
10 20 30 40 50 60
pF1KB3 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
: ::.:.. . . . :: ::....:.:.: .::. : ::.. .
NP_000 MLEKFCNSTFWNSSF-LDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSR
10 20 30 40 50
70 80 90 100 110
pF1KB3 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAP-VFFVTP-LVVGVTMLL
..: :.:. .: .. .: . :.: .: : ...: : .:. .:.
NP_000 TKRSSTTKLYLAKQVFVGFLLILAAIELALVLTED-SGQATVPAVRYTNPSLYLGTWLLV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 ATLLIQYERLQGVQ-SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIH
::::: : :: .: : .::.: ..:. :.. .. . .:. :. :.:
NP_000 --LLIQYSRQWCVQKNSWFLSLFWILSILCGTFQFQT-LIRTLLQGDNSNLAYSCLFFIS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB3 FALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEE
... . ::.. : : : . . : . :.::: . . :. .. . ::..::
NP_000 YGFQILILIFSAFSE--------NNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTL
180 190 200 210 220
240 250 260 270 280
pF1KB3 KDLWSLKEEDRSQMVV--------QQLLEA----WRKQEKQTARHKASAAPG--KNAS-G
.:.: . :: ... .: ..: .: :.:::.. ..... :: :: : .
NP_000 EDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQS
230 240 250 260 270 280
290 300 310 320 330
pF1KB3 EDEVLLGARPRPRKPS----------FLKALLATFGSSFLISACFKLIQDLLSFINPQLL
.: ..: . .: : ..:::. :: .: : .::..:...:..::::
NP_000 QDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLL
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB3 SILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRK
..:: : :. . : :.: : :.: ...::. :: :.. : ::: ::.::. .:.:
NP_000 KLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKK
350 360 370 380 390 400
400 410 420 430 440 450
pF1KB3 ALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSV
::...: ... :::: :::::::::..::.. :...:::. :::.:.:.:::..:::::
NP_000 ALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSV
410 420 430 440 450 460
460 470 480 490 500 510
pF1KB3 LAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLK
::::. :::.::.:. ...: ...:::.:: ::.:.:.:.:::.:::.:: .::::::
NP_000 LAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRD
470 480 490 500 510 520
520 530 540 550 560 570
pF1KB3 QVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSV
::...:. ::. : . . :. .. :... .: ::...:. ::: :: ::.:::.:::.:.
NP_000 QVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSI
530 540 550 560 570 580
580 590 600 610 620 630
pF1KB3 SLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSG
.::::::.::.:::..::.. ::::: .:....:. ..:: ... :. . :. . .
NP_000 TLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAI-RHDCNFDKAMQFSEA
590 600 610 620 630 640
640 650 660 670 680 690
pF1KB3 TFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVA
.::: .: :........ : ::::.:::: :::::.::.:::::...:.. .::..:
NP_000 SFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTA
650 660 670 680 690 700
700 710 720 730 740 750
pF1KB3 YVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLS
:::::.:::: :...:.::: .: :::::.::::::: ::::::::: .::::::::::
NP_000 YVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLS
710 720 730 740 750 760
760 770 780 790 800 810
pF1KB3 GGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGI
:::.::.:::::.:.. ::.::::::::::.::.::::..:.::.:.: ::::.::::..
NP_000 GGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSM
770 780 790 800 810 820
820 830 840 850 860
pF1KB3 SFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFAN----FLCNYAPDEDQGHLEDSWTAL
::::.: :.::..: . : : : ::: ..: ::. :: . .:.:. :.
NP_000 HFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEA-------TVH
830 840 850 860 870
870 880 890 900 910 920
pF1KB3 EGAEDKEALLIED--TLSNHTDLT-DNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRH
.:.:... .: .:. .. : .:. ...: : :: :: ..:. :
NP_000 DGSEEED----DDYGLISSVEEIPEDAASITMRRENSFRRTLSR-SSRSNGRHLKSLRNS
880 890 900 910 920 930
930 940 950 960 970 980
pF1KB3 LGPSE--KVQVTEAKADGA-LTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQS
: . ... : . : : ..: : :..:.. .: .:.:: . . : : .: .:
NP_000 LKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNS
940 950 960 970 980 990
990 1000 1010 1020 1030
pF1KB3 AAAIGANVWLSAWTNDAM----ADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGI
.: ::.:.::::::.:. .: .. ..:.:::.:::. ::..:..: . : : .
NP_000 VAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFV
1000 1010 1020 1030 1040 1050
1040 1050 1060 1070 1080 1090
pF1KB3 QAARVLHQALPHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAI
.:. .::. : .: .:.:. ::::::.:::.: :. :: .::..: . .. :.. :
NP_000 HASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGII
1060 1070 1080 1090 1100 1110
1100 1110 1120 1130 1140 1150
pF1KB3 STLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGA
::::.: .::.::....::...:. :: ::..:::::.::.::.::::::::::::.:
NP_000 STLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGL
1120 1130 1140 1150 1160 1170
1160 1170 1180 1190 1200 1210
pF1KB3 SVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGR
::::..... : .....:.::. . .: :::::.: .:.::: .:.:.::. :: :
NP_000 PVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYR
1180 1190 1200 1210 1220 1230
1220 1230 1240 1250 1260 1270
pF1KB3 SSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSR
..:. ::. .: .:..: .:::..:: :..:.:::::::. ::.:.:.:::::.. .:
NP_000 DTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTD-KR
1240 1250 1260 1270 1280
1280 1290 1300 1310 1320 1330
pF1KB3 PPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFR
:: :: .:...: ::.::::: :::::: .. . . ::.:.::::::::::.: ::::
NP_000 PPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFR
1290 1300 1310 1320 1330 1340
1340 1350 1360 1370 1380 1390
pF1KB3 ILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWA
::::: :.: :::...:.::::::: .:::::::::::::.::::::::..::.:.:: :
NP_000 ILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKA
1350 1360 1370 1380 1390 1400
1400 1410 1420 1430 1440 1450
pF1KB3 LELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDL
:::.::..::.: ::. . .:.: :::.:::::.::.:::::::.::::::::::.::
NP_000 LELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDL
1410 1420 1430 1440 1450 1460
1460 1470 1480 1490 1500 1510
pF1KB3 ETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY
:::::::.::...: :::.::::::.:::: .:.:::.: . : :: .:. : ::
NP_000 ETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFY
1470 1480 1490 1500 1510 1520
1520
pF1KB3 GMARDAGLA
::..::.
NP_000 FMAKEAGIENVNSTKF
1530 1540
1527 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 12:59:21 2016 done: Thu Nov 3 12:59:24 2016
Total Scan time: 15.950 Total Display time: 0.890
Function used was FASTA [36.3.4 Apr, 2011]