Result of FASTA (omim) for
pFN21AA0720
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0720, 1062 aa
1>>>pF1KA0720 1062 - 1062 aa - 1062 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.6289+/-0.00039; mu= -7.1019+/- 0.024
mean_var=348.1343+/-72.565, 0's: 0 Z-trim(123.3): 152 B-trim: 412 in 1/54
Lambda= 0.068739
statistics sampled from 42711 (42866) to 42711 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.791), E-opt: 0.2 (0.503), width: 16
Scan time: 16.920
The best scores are: opt bits E(85289)
NP_001036128 (OMIM: 611067,611101,615376) pleckstr (1062) 7155 724.2 9.8e-208
NP_941374 (OMIM: 611067,611101,615376) pleckstrin (1083) 7148 723.5 1.6e-207
NP_001252521 (OMIM: 611067,611101,615376) pleckstr (1085) 7140 722.7 2.8e-207
NP_001252522 (OMIM: 611067,611101,615376) pleckstr (1075) 6969 705.7 3.5e-202
NP_001036130 (OMIM: 611067,611101,615376) pleckstr (1006) 6734 682.4 3.5e-195
NP_001036129 (OMIM: 611067,611101,615376) pleckstr (1006) 6734 682.4 3.5e-195
NP_065682 (OMIM: 611067,611101,615376) pleckstrin (1006) 6734 682.4 3.5e-195
NP_001252523 (OMIM: 611067,611101,615376) pleckstr ( 930) 6091 618.6 5.1e-176
NP_001138329 (OMIM: 611743) pleckstrin homology do ( 758) 1391 152.4 8.8e-36
XP_011519269 (OMIM: 611743) PREDICTED: pleckstrin ( 768) 1391 152.4 8.9e-36
XP_016875044 (OMIM: 611743) PREDICTED: pleckstrin ( 788) 1391 152.5 9.1e-36
NP_001138328 (OMIM: 611743) pleckstrin homology do ( 790) 1391 152.5 9.1e-36
NP_060643 (OMIM: 611743) pleckstrin homology domai ( 790) 1391 152.5 9.1e-36
XP_005253761 (OMIM: 611743) PREDICTED: pleckstrin ( 790) 1391 152.5 9.1e-36
XP_006719048 (OMIM: 611743) PREDICTED: pleckstrin ( 776) 782 92.1 1.4e-17
XP_016872911 (OMIM: 604763) PREDICTED: rho guanine (1401) 498 64.1 6.6e-09
XP_011541022 (OMIM: 604763) PREDICTED: rho guanine (1441) 498 64.1 6.7e-09
XP_016872910 (OMIM: 604763) PREDICTED: rho guanine (1441) 498 64.1 6.7e-09
NP_001288013 (OMIM: 604763) rho guanine nucleotide (1441) 498 64.1 6.7e-09
XP_016872909 (OMIM: 604763) PREDICTED: rho guanine (1485) 498 64.1 6.9e-09
XP_006718868 (OMIM: 604763) PREDICTED: rho guanine (1519) 498 64.1 7e-09
NP_001185594 (OMIM: 604763) rho guanine nucleotide (1525) 498 64.1 7e-09
NP_056128 (OMIM: 604763) rho guanine nucleotide ex (1544) 498 64.1 7.1e-09
XP_005259443 (OMIM: 601855) PREDICTED: rho guanine (1041) 441 58.3 2.6e-07
XP_011525770 (OMIM: 601855) PREDICTED: rho guanine ( 985) 435 57.7 3.8e-07
NP_945328 (OMIM: 601855) rho guanine nucleotide ex ( 879) 428 57.0 5.6e-07
NP_004697 (OMIM: 601855) rho guanine nucleotide ex ( 912) 428 57.0 5.7e-07
NP_945353 (OMIM: 601855) rho guanine nucleotide ex ( 927) 428 57.0 5.8e-07
XP_005259447 (OMIM: 601855) PREDICTED: rho guanine ( 981) 428 57.0 6.1e-07
XP_011508491 (OMIM: 605708) PREDICTED: rho guanine ( 945) 407 54.9 2.5e-06
XP_005245690 (OMIM: 605708) PREDICTED: rho guanine (1141) 407 55.0 2.9e-06
XP_011508489 (OMIM: 605708) PREDICTED: rho guanine (1485) 407 55.1 3.6e-06
NP_055599 (OMIM: 605708) rho guanine nucleotide ex (1522) 407 55.1 3.7e-06
XP_016858413 (OMIM: 605708) PREDICTED: rho guanine (1523) 407 55.1 3.7e-06
XP_016858412 (OMIM: 605708) PREDICTED: rho guanine (1523) 407 55.1 3.7e-06
XP_016858411 (OMIM: 605708) PREDICTED: rho guanine (1528) 407 55.1 3.7e-06
XP_006711728 (OMIM: 605708) PREDICTED: rho guanine (1538) 407 55.1 3.7e-06
XP_011508488 (OMIM: 605708) PREDICTED: rho guanine (1539) 407 55.1 3.7e-06
XP_016858410 (OMIM: 605708) PREDICTED: rho guanine (1552) 407 55.1 3.7e-06
XP_006711726 (OMIM: 605708) PREDICTED: rho guanine (1559) 407 55.1 3.7e-06
NP_937879 (OMIM: 605708) rho guanine nucleotide ex (1562) 407 55.1 3.7e-06
XP_005245686 (OMIM: 605708) PREDICTED: rho guanine (1563) 407 55.1 3.7e-06
XP_016858409 (OMIM: 605708) PREDICTED: rho guanine (1568) 407 55.1 3.7e-06
XP_006711725 (OMIM: 605708) PREDICTED: rho guanine (1568) 407 55.1 3.7e-06
XP_006711724 (OMIM: 605708) PREDICTED: rho guanine (1569) 407 55.1 3.7e-06
XP_011508487 (OMIM: 605708) PREDICTED: rho guanine (1574) 407 55.1 3.8e-06
XP_006711723 (OMIM: 605708) PREDICTED: rho guanine (1578) 407 55.1 3.8e-06
XP_006711722 (OMIM: 605708) PREDICTED: rho guanine (1579) 407 55.1 3.8e-06
>>NP_001036128 (OMIM: 611067,611101,615376) pleckstrin h (1062 aa)
initn: 7155 init1: 7155 opt: 7155 Z-score: 3850.5 bits: 724.2 E(85289): 9.8e-208
Smith-Waterman score: 7155; 99.9% identity (100.0% similar) in 1062 aa overlap (1-1062:1-1062)
10 20 30 40 50 60
pF1KA0 MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 GHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 RRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 SNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 VDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNSGDSWKN
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_001 VDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 RAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 EDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 CLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 FKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 IDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 CFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTF
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 QASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 EDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 DETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 ESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 LCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGA
970 980 990 1000 1010 1020
1030 1040 1050 1060
pF1KA0 SPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
::::::::::::::::::::::::::::::::::::::::::
NP_001 SPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
1030 1040 1050 1060
>>NP_941374 (OMIM: 611067,611101,615376) pleckstrin homo (1083 aa)
initn: 7148 init1: 7148 opt: 7148 Z-score: 3846.6 bits: 723.5 E(85289): 1.6e-207
Smith-Waterman score: 7148; 99.9% identity (100.0% similar) in 1061 aa overlap (2-1062:23-1083)
10 20 30
pF1KA0 MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHR
::::::::::::::::::::::::::::::::::::::
NP_941 MNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQLHR
10 20 30 40 50 60
40 50 60 70 80 90
pF1KA0 RGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 RGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEE
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA0 SSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 SSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEV
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA0 LLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 LLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKD
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA0 SKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 SKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTP
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA0 SSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLF
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
NP_941 SSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLF
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA0 GLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 GLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWE
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA0 LLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 LLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMA
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA0 PVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 PVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYI
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA0 TWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 TWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIH
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA0 HVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 HVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETR
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA0 QLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 QLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRD
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA0 PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQS
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA0 LEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 LEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVV
790 800 810 820 830 840
820 830 840 850 860 870
pF1KA0 VEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 VEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLS
850 860 870 880 890 900
880 890 900 910 920 930
pF1KA0 PTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 PTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLL
910 920 930 940 950 960
940 950 960 970 980 990
pF1KA0 QLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 QLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KA0 CLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_941 CLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTA
1030 1040 1050 1060 1070 1080
1060
pF1KA0 SEV
:::
NP_941 SEV
>>NP_001252521 (OMIM: 611067,611101,615376) pleckstrin h (1085 aa)
initn: 7140 init1: 7140 opt: 7140 Z-score: 3842.3 bits: 722.7 E(85289): 2.8e-207
Smith-Waterman score: 7140; 99.9% identity (100.0% similar) in 1060 aa overlap (3-1062:26-1085)
10 20 30
pF1KA0 MDDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQL
:::::::::::::::::::::::::::::::::::
NP_001 MSLGERGSPQTFGGSSVSKGSDAGHDQSPAEKKGLRCQNPACMDKGRAAKVCHHADCQQL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KA0 HRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEE
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA0 EESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLG
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA0 EVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGM
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA0 KDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPP
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA0 TPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYS
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
NP_001 TPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYS
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA0 LFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAV
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA0 WELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASV
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA0 MAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRA
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA0 YITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERF
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA0 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA0 TRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCREL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCREL
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA0 RDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA0 QSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAM
790 800 810 820 830 840
820 830 840 850 860 870
pF1KA0 VVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGT
850 860 870 880 890 900
880 890 900 910 920 930
pF1KA0 LSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS
910 920 930 940 950 960
940 950 960 970 980 990
pF1KA0 LLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGL
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KA0 VGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTL
1030 1040 1050 1060 1070 1080
1060
pF1KA0 TASEV
:::::
NP_001 TASEV
>>NP_001252522 (OMIM: 611067,611101,615376) pleckstrin h (1075 aa)
initn: 6963 init1: 6963 opt: 6969 Z-score: 3750.7 bits: 705.7 E(85289): 3.5e-202
Smith-Waterman score: 6969; 98.1% identity (98.8% similar) in 1061 aa overlap (6-1062:16-1075)
10 20 30 40
pF1KA0 MDDQSPAEKKGLRCQNPACMDKGRA----AKVCHHADCQQLHRRGPLNLC
:. :: ..:. ::: ..:::::::::::::::::::
NP_001 MGTGPGVSGRLAASRPGPGLPLRDSEPS-WAGGRARDGDSQVCHHADCQQLHRRGPLNLC
10 20 30 40 50
50 60 70 80 90 100
pF1KA0 EACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKG
60 70 80 90 100 110
110 120 130 140 150 160
pF1KA0 DRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFER
120 130 140 150 160 170
170 180 190 200 210 220
pF1KA0 KGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLP
180 190 200 210 220 230
230 240 250 260 270 280
pF1KA0 ILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPS
240 250 260 270 280 290
290 300 310 320 330 340
pF1KA0 GSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPR
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPR
300 310 320 330 340 350
350 360 370 380 390 400
pF1KA0 GLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEAS
360 370 380 390 400 410
410 420 430 440 450 460
pF1KA0 YIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKAR
420 430 440 450 460 470
470 480 490 500 510 520
pF1KA0 RTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHP
480 490 500 510 520 530
530 540 550 560 570 580
pF1KA0 QCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMR
540 550 560 570 580 590
590 600 610 620 630 640
pF1KA0 QRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGS
600 610 620 630 640 650
650 660 670 680 690 700
pF1KA0 LRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLI
660 670 680 690 700 710
710 720 730 740 750 760
pF1KA0 YLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDE
720 730 740 750 760 770
770 780 790 800 810 820
pF1KA0 QEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTL
780 790 800 810 820 830
830 840 850 860 870 880
pF1KA0 SSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF
840 850 860 870 880 890
890 900 910 920 930 940
pF1KA0 VAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAG
900 910 920 930 940 950
950 960 970 980 990 1000
pF1KA0 THGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPA
960 970 980 990 1000 1010
1010 1020 1030 1040 1050 1060
pF1KA0 GSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
1020 1030 1040 1050 1060 1070
>>NP_001036130 (OMIM: 611067,611101,615376) pleckstrin h (1006 aa)
initn: 6734 init1: 6734 opt: 6734 Z-score: 3625.2 bits: 682.4 E(85289): 3.5e-195
Smith-Waterman score: 6734; 99.9% identity (100.0% similar) in 1006 aa overlap (57-1062:1-1006)
30 40 50 60 70 80
pF1KA0 KVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPR
::::::::::::::::::::::::::::::
NP_001 MHYDGHVRFDLPPQGSVLARNVSTRSCPPR
10 20 30
90 100 110 120 130 140
pF1KA0 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
40 50 60 70 80 90
150 160 170 180 190 200
pF1KA0 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
100 110 120 130 140 150
210 220 230 240 250 260
pF1KA0 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
160 170 180 190 200 210
270 280 290 300 310 320
pF1KA0 GEASIPGQEPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
NP_001 GEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
220 230 240 250 260 270
330 340 350 360 370 380
pF1KA0 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
280 290 300 310 320 330
390 400 410 420 430 440
pF1KA0 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
340 350 360 370 380 390
450 460 470 480 490 500
pF1KA0 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
400 410 420 430 440 450
510 520 530 540 550 560
pF1KA0 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
460 470 480 490 500 510
570 580 590 600 610 620
pF1KA0 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
520 530 540 550 560 570
630 640 650 660 670 680
pF1KA0 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
580 590 600 610 620 630
690 700 710 720 730 740
pF1KA0 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
640 650 660 670 680 690
750 760 770 780 790 800
pF1KA0 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
700 710 720 730 740 750
810 820 830 840 850 860
pF1KA0 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
760 770 780 790 800 810
870 880 890 900 910 920
pF1KA0 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
820 830 840 850 860 870
930 940 950 960 970 980
pF1KA0 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
880 890 900 910 920 930
990 1000 1010 1020 1030 1040
pF1KA0 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
940 950 960 970 980 990
1050 1060
pF1KA0 IRTTLLLNSTLTASEV
::::::::::::::::
NP_001 IRTTLLLNSTLTASEV
1000
>>NP_001036129 (OMIM: 611067,611101,615376) pleckstrin h (1006 aa)
initn: 6734 init1: 6734 opt: 6734 Z-score: 3625.2 bits: 682.4 E(85289): 3.5e-195
Smith-Waterman score: 6734; 99.9% identity (100.0% similar) in 1006 aa overlap (57-1062:1-1006)
30 40 50 60 70 80
pF1KA0 KVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPR
::::::::::::::::::::::::::::::
NP_001 MHYDGHVRFDLPPQGSVLARNVSTRSCPPR
10 20 30
90 100 110 120 130 140
pF1KA0 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
40 50 60 70 80 90
150 160 170 180 190 200
pF1KA0 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
100 110 120 130 140 150
210 220 230 240 250 260
pF1KA0 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
160 170 180 190 200 210
270 280 290 300 310 320
pF1KA0 GEASIPGQEPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
NP_001 GEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
220 230 240 250 260 270
330 340 350 360 370 380
pF1KA0 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
280 290 300 310 320 330
390 400 410 420 430 440
pF1KA0 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
340 350 360 370 380 390
450 460 470 480 490 500
pF1KA0 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
400 410 420 430 440 450
510 520 530 540 550 560
pF1KA0 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
460 470 480 490 500 510
570 580 590 600 610 620
pF1KA0 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
520 530 540 550 560 570
630 640 650 660 670 680
pF1KA0 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
580 590 600 610 620 630
690 700 710 720 730 740
pF1KA0 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
640 650 660 670 680 690
750 760 770 780 790 800
pF1KA0 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
700 710 720 730 740 750
810 820 830 840 850 860
pF1KA0 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
760 770 780 790 800 810
870 880 890 900 910 920
pF1KA0 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
820 830 840 850 860 870
930 940 950 960 970 980
pF1KA0 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
880 890 900 910 920 930
990 1000 1010 1020 1030 1040
pF1KA0 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
940 950 960 970 980 990
1050 1060
pF1KA0 IRTTLLLNSTLTASEV
::::::::::::::::
NP_001 IRTTLLLNSTLTASEV
1000
>>NP_065682 (OMIM: 611067,611101,615376) pleckstrin homo (1006 aa)
initn: 6734 init1: 6734 opt: 6734 Z-score: 3625.2 bits: 682.4 E(85289): 3.5e-195
Smith-Waterman score: 6734; 99.9% identity (100.0% similar) in 1006 aa overlap (57-1062:1-1006)
30 40 50 60 70 80
pF1KA0 KVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPR
::::::::::::::::::::::::::::::
NP_065 MHYDGHVRFDLPPQGSVLARNVSTRSCPPR
10 20 30
90 100 110 120 130 140
pF1KA0 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
40 50 60 70 80 90
150 160 170 180 190 200
pF1KA0 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
100 110 120 130 140 150
210 220 230 240 250 260
pF1KA0 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
160 170 180 190 200 210
270 280 290 300 310 320
pF1KA0 GEASIPGQEPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
NP_065 GEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
220 230 240 250 260 270
330 340 350 360 370 380
pF1KA0 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
280 290 300 310 320 330
390 400 410 420 430 440
pF1KA0 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
340 350 360 370 380 390
450 460 470 480 490 500
pF1KA0 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
400 410 420 430 440 450
510 520 530 540 550 560
pF1KA0 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
460 470 480 490 500 510
570 580 590 600 610 620
pF1KA0 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
520 530 540 550 560 570
630 640 650 660 670 680
pF1KA0 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
580 590 600 610 620 630
690 700 710 720 730 740
pF1KA0 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
640 650 660 670 680 690
750 760 770 780 790 800
pF1KA0 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
700 710 720 730 740 750
810 820 830 840 850 860
pF1KA0 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
760 770 780 790 800 810
870 880 890 900 910 920
pF1KA0 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
820 830 840 850 860 870
930 940 950 960 970 980
pF1KA0 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
880 890 900 910 920 930
990 1000 1010 1020 1030 1040
pF1KA0 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
940 950 960 970 980 990
1050 1060
pF1KA0 IRTTLLLNSTLTASEV
::::::::::::::::
NP_065 IRTTLLLNSTLTASEV
1000
>>NP_001252523 (OMIM: 611067,611101,615376) pleckstrin h (930 aa)
initn: 6078 init1: 6078 opt: 6091 Z-score: 3281.1 bits: 618.6 E(85289): 5.1e-176
Smith-Waterman score: 6091; 98.6% identity (99.2% similar) in 928 aa overlap (57-984:1-926)
30 40 50 60 70 80
pF1KA0 KVCHHADCQQLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTRSCPPR
::::::::::::::::::::::::::::::
NP_001 MHYDGHVRFDLPPQGSVLARNVSTRSCPPR
10 20 30
90 100 110 120 130 140
pF1KA0 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETE
40 50 60 70 80 90
150 160 170 180 190 200
pF1KA0 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAK
100 110 120 130 140 150
210 220 230 240 250 260
pF1KA0 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFL
160 170 180 190 200 210
270 280 290 300 310 320
pF1KA0 GEASIPGQEPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
NP_001 GEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKM
220 230 240 250 260 270
330 340 350 360 370 380
pF1KA0 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKL
280 290 300 310 320 330
390 400 410 420 430 440
pF1KA0 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEI
340 350 360 370 380 390
450 460 470 480 490 500
pF1KA0 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
400 410 420 430 440 450
510 520 530 540 550 560
pF1KA0 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEA
460 470 480 490 500 510
570 580 590 600 610 620
pF1KA0 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDL
520 530 540 550 560 570
630 640 650 660 670 680
pF1KA0 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPP
580 590 600 610 620 630
690 700 710 720 730 740
pF1KA0 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLR
640 650 660 670 680 690
750 760 770 780 790 800
pF1KA0 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHC
700 710 720 730 740 750
810 820 830 840 850 860
pF1KA0 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDG
760 770 780 790 800 810
870 880 890 900 910 920
pF1KA0 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCP
820 830 840 850 860 870
930 940 950 960 970 980
pF1KA0 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCR
::::::::::::::::::::::::::::::::::::::::::. ...: : :. :
NP_001 PHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPA--QEADPGPALPNQDHP
880 890 900 910 920
990 1000 1010 1020 1030 1040
pF1KA0 GAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
NP_001 AA
930
>>NP_001138329 (OMIM: 611743) pleckstrin homology domain (758 aa)
initn: 1467 init1: 1272 opt: 1391 Z-score: 763.4 bits: 152.4 E(85289): 8.8e-36
Smith-Waterman score: 1458; 36.7% identity (62.0% similar) in 768 aa overlap (305-1062:50-758)
280 290 300 310 320 330
pF1KA0 EPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLH
: .: ..: : .:. : ..:: .::
NP_001 RLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLH
20 30 40 50 60 70
340 350 360 370 380 390
pF1KA0 TYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQ
:.:.::.:::: :. :: : :.. : .: :::::. ::...... ::::
NP_001 TFSMFGMPRLP---PEDRRHWEI----GEGGDSG-LTIEKSWRELVPGHKEMSQELCHQQ
80 90 100 110 120 130
400 410 420 430 440 450
pF1KA0 EAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLW
::.:::: :: :.:::... .:. :::::. ::: :: :: ::.:.: . . :: .:
NP_001 EALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFW
140 150 160 170 180 190
460 470 480 490 500 510
pF1KA0 ASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDL
:..:.::..: . :.: . .:: ::. :.::..::.. . : : : . : :
NP_001 DEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPL
200 210 220 230 240 250
520 530 540 550 560 570
pF1KA0 FRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSV
:.:.. : ::: . : : :.: :::::.:::::::..::... : ::.::. ::: .:
NP_001 FHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAV
260 270 280 290 300 310
580 590 600 610 620 630
pF1KA0 ERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGAS
: :..:.:. .:: .:.. :::...:: :::.: ::::.: :. : ::::.:. :..
NP_001 ESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVA
320 330 340 350 360 370
640 650 660 670 680 690
pF1KA0 PEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVC
:.:::::::: .:.:::...:.::: :::.:.::::: .::....::::::...:.::
NP_001 SEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVC
380 390 400 410 420 430
700 710 720 730 740 750
pF1KA0 RELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQ
. ::::.:::::.:.::. . .: . . . :.. .:: ::.:.:.: ..
NP_001 QPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQK
440 450 460 470 480 490
760 770 780 790 800 810
pF1KA0 QPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTET
. : .: ...:.. ::. : :. : .... ...: :
NP_001 RELLTLYRDQDRE----------------------SPST-RPSTPSLEGSQSSAEGRTPE
500 510 520
820 830 840 850 860 870
pF1KA0 LAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSA
.. .. : ... ...:. .. : : .:::. ::. . :. :
NP_001 FSTII--PHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPR
530 540 550 560 570 580
880 890 900 910 920 930
pF1KA0 YGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKS
:.: :.:. :. : :..:. : : :. . :: . ..
NP_001 L-TFSTLELRDI----PLRPHPPD-PQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEED
590 600 610 620 630 640
940 950 960 970 980
pF1KA0 EAS-----LLQLLAGAGTHGT-PSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGA
:: ... : : .: ::.:... : : .: ...: .: :: . :
NP_001 GASERGNVVVETLHRARLRGQLPSSPTHADS----AGESPW-ESSGEEEEEGPLFLKAGH
650 660 670 680 690
990 1000 1010 1020 1030 1040
pF1KA0 PS--PGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
: : . .. . : : :.: . .. : . :: ::: ::: :
NP_001 TSLRPMRAEDMLREIREELA-SQRIEGAEEPRDSRPR--------------KLTRAQLQR
700 710 720 730 740
1050 1060
pF1KA0 IRTT--LLLNSTLTASEV
.: . :.. :.::::
NP_001 MRGPHIIQLDTPLSASEV
750
>>XP_011519269 (OMIM: 611743) PREDICTED: pleckstrin homo (768 aa)
initn: 1435 init1: 1272 opt: 1391 Z-score: 763.3 bits: 152.4 E(85289): 8.9e-36
Smith-Waterman score: 1458; 36.7% identity (62.0% similar) in 768 aa overlap (305-1062:60-768)
280 290 300 310 320 330
pF1KA0 EPPTPSSCSLPSGSSGSTNSGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLH
: .: ..: : .:. : ..:: .::
XP_011 DSIPEDTLCWGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLH
30 40 50 60 70 80
340 350 360 370 380 390
pF1KA0 TYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCHQQ
:.:.::.:::: :. :: : :.. : .: :::::. ::...... ::::
XP_011 TFSMFGMPRLP---PEDRRHWEI----GEGGDSG-LTIEKSWRELVPGHKEMSQELCHQQ
90 100 110 120 130 140
400 410 420 430 440 450
pF1KA0 EAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLW
::.:::: :: :.:::... .:. :::::. ::: :: :: ::.:.: . . :: .:
XP_011 EALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFW
150 160 170 180 190 200
460 470 480 490 500 510
pF1KA0 ASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDL
:..:.::..: . :.: . .:: ::. :.::..::.. . : : : . : :
XP_011 DEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPL
210 220 230 240 250 260
520 530 540 550 560 570
pF1KA0 FRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSV
:.:.. : ::: . : : :.: :::::.:::::::..::... : ::.::. ::: .:
XP_011 FHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAV
270 280 290 300 310 320
580 590 600 610 620 630
pF1KA0 ERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGAS
: :..:.:. .:: .:.. :::...:: :::.: ::::.: :. : ::::.:. :..
XP_011 ESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVA
330 340 350 360 370 380
640 650 660 670 680 690
pF1KA0 PEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVC
:.:::::::: .:.:::...:.::: :::.:.::::: .::....::::::...:.::
XP_011 SEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVC
390 400 410 420 430 440
700 710 720 730 740 750
pF1KA0 RELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQ
. ::::.:::::.:.::. . .: . . . :.. .:: ::.:.:.: ..
XP_011 QPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQK
450 460 470 480 490 500
760 770 780 790 800 810
pF1KA0 QPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRKSSGSPDSQHCASDGSTET
. : .: ...:.. ::. : :. : .... ...: :
XP_011 RELLTLYRDQDRE----------------------SPST-RPSTPSLEGSQSSAEGRTPE
510 520 530
820 830 840 850 860 870
pF1KA0 LAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATPTSELLPLGPVDGRSCSMDSA
.. .. : ... ...:. .. : : .:::. ::. . :. :
XP_011 FSTII--PHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPR
540 550 560 570 580 590
880 890 900 910 920 930
pF1KA0 YGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKS
:.: :.:. :. : :..:. : : :. . :: . ..
XP_011 L-TFSTLELRDI----PLRPHPPD-PQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEED
600 610 620 630 640 650
940 950 960 970 980
pF1KA0 EAS-----LLQLLAGAGTHGT-PSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGA
:: ... : : .: ::.:... : : .: ...: .: :: . :
XP_011 GASERGNVVVETLHRARLRGQLPSSPTHADS----AGESPW-ESSGEEEEEGPLFLKAGH
660 670 680 690 700
990 1000 1010 1020 1030 1040
pF1KA0 PS--PGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEPPPGVSAQHRKLTLAQLYR
: : . .. . : : :.: . .. : . :: ::: ::: :
XP_011 TSLRPMRAEDMLREIREELA-SQRIEGAEEPRDSRPR--------------KLTRAQLQR
710 720 730 740 750
1050 1060
pF1KA0 IRTT--LLLNSTLTASEV
.: . :.. :.::::
XP_011 MRGPHIIQLDTPLSASEV
760
1062 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 10:05:28 2016 done: Thu Nov 3 10:05:31 2016
Total Scan time: 16.920 Total Display time: 0.300
Function used was FASTA [36.3.4 Apr, 2011]