Result of FASTA (omim) for
pFN21ASDA0638
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0638, 1377 aa
1>>>pF1KSDA0638 1377 - 1377 aa - 1377 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.9133+/-0.000459; mu= -27.0459+/- 0.028
mean_var=557.9679+/-115.524, 0's: 0 Z-trim(123.1): 61 B-trim: 631 in 1/57
Lambda= 0.054296
statistics sampled from 42354 (42416) to 42354 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.497), width: 16
Scan time: 15.170
The best scores are: opt bits E(85289)
NP_001138230 (OMIM: 612834) pleckstrin homology-li (1377) 9054 725.0 9e-208
NP_055972 (OMIM: 612834) pleckstrin homology-like (1377) 9054 725.0 9e-208
XP_005271527 (OMIM: 612834) PREDICTED: pleckstrin (1423) 9054 725.0 9.2e-208
XP_005271528 (OMIM: 612834) PREDICTED: pleckstrin (1412) 8666 694.6 1.3e-198
XP_006718865 (OMIM: 612834) PREDICTED: pleckstrin (1419) 8053 646.6 3.7e-184
XP_006718866 (OMIM: 612834) PREDICTED: pleckstrin (1408) 7665 616.2 5.2e-175
XP_005271526 (OMIM: 612834) PREDICTED: pleckstrin (1427) 7097 571.7 1.3e-161
XP_005271525 (OMIM: 612834) PREDICTED: pleckstrin (1438) 6833 551.1 2.2e-155
XP_011541009 (OMIM: 612834) PREDICTED: pleckstrin (1543) 6080 492.1 1.3e-137
XP_016872896 (OMIM: 612834) PREDICTED: pleckstrin (1542) 6063 490.8 3.3e-137
XP_005271529 (OMIM: 612834) PREDICTED: pleckstrin (1391) 6014 486.9 4.4e-136
NP_001138231 (OMIM: 612834) pleckstrin homology-li (1319) 5996 485.5 1.1e-135
XP_005271531 (OMIM: 612834) PREDICTED: pleckstrin (1365) 5996 485.5 1.1e-135
XP_005271530 (OMIM: 612834) PREDICTED: pleckstrin (1376) 5996 485.5 1.2e-135
XP_016872899 (OMIM: 612834) PREDICTED: pleckstrin (1495) 5987 484.8 2e-135
XP_006718864 (OMIM: 612834) PREDICTED: pleckstrin (1434) 5862 475.0 1.7e-132
XP_006718860 (OMIM: 612834) PREDICTED: pleckstrin (1538) 5365 436.1 9.6e-121
XP_016872897 (OMIM: 612834) PREDICTED: pleckstrin (1512) 5358 435.5 1.4e-120
XP_011541010 (OMIM: 612834) PREDICTED: pleckstrin (1540) 5334 433.7 5.2e-120
XP_011541011 (OMIM: 612834) PREDICTED: pleckstrin (1540) 5334 433.7 5.2e-120
XP_011541008 (OMIM: 612834) PREDICTED: pleckstrin (1560) 5334 433.7 5.2e-120
XP_011541007 (OMIM: 612834) PREDICTED: pleckstrin (1571) 5334 433.7 5.3e-120
XP_011541006 (OMIM: 612834) PREDICTED: pleckstrin (1575) 5334 433.7 5.3e-120
XP_011541005 (OMIM: 612834) PREDICTED: pleckstrin (1586) 5334 433.7 5.3e-120
XP_016872898 (OMIM: 612834) PREDICTED: pleckstrin (1503) 5328 433.2 7e-120
XP_011541012 (OMIM: 612834) PREDICTED: pleckstrin (1529) 5328 433.2 7.1e-120
XP_006718863 (OMIM: 612834) PREDICTED: pleckstrin (1455) 5321 432.6 1e-119
XP_006718862 (OMIM: 612834) PREDICTED: pleckstrin (1466) 5321 432.6 1e-119
XP_006718861 (OMIM: 612834) PREDICTED: pleckstrin (1481) 5321 432.6 1e-119
XP_006718859 (OMIM: 612834) PREDICTED: pleckstrin (1539) 5317 432.3 1.3e-119
XP_005277737 (OMIM: 612834) PREDICTED: pleckstrin (1585) 5317 432.3 1.3e-119
XP_011541016 (OMIM: 612834) PREDICTED: pleckstrin ( 848) 5269 428.4 1.1e-118
XP_016872900 (OMIM: 612834) PREDICTED: pleckstrin ( 858) 5263 428.0 1.5e-118
XP_005271532 (OMIM: 612834) PREDICTED: pleckstrin ( 858) 5263 428.0 1.5e-118
XP_011541013 (OMIM: 612834) PREDICTED: pleckstrin (1420) 4522 370.0 6.8e-101
XP_011541015 (OMIM: 612834) PREDICTED: pleckstrin (1419) 4505 368.7 1.7e-100
XP_011541017 (OMIM: 612834) PREDICTED: pleckstrin ( 721) 2446 207.3 3.4e-52
NP_665696 (OMIM: 610298) pleckstrin homology-like (1210) 1322 119.3 1.7e-25
NP_001127909 (OMIM: 610298) pleckstrin homology-li (1237) 1322 119.3 1.7e-25
NP_001127911 (OMIM: 610298) pleckstrin homology-li (1253) 1144 105.4 2.8e-21
NP_001127910 (OMIM: 610298) pleckstrin homology-li (1253) 1144 105.4 2.8e-21
>>NP_001138230 (OMIM: 612834) pleckstrin homology-like d (1377 aa)
initn: 9054 init1: 9054 opt: 9054 Z-score: 3851.2 bits: 725.0 E(85289): 9e-208
Smith-Waterman score: 9054; 100.0% identity (100.0% similar) in 1377 aa overlap (1-1377:1-1377)
10 20 30 40 50 60
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370
pF1KSD KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1330 1340 1350 1360 1370
>>NP_055972 (OMIM: 612834) pleckstrin homology-like doma (1377 aa)
initn: 9054 init1: 9054 opt: 9054 Z-score: 3851.2 bits: 725.0 E(85289): 9e-208
Smith-Waterman score: 9054; 100.0% identity (100.0% similar) in 1377 aa overlap (1-1377:1-1377)
10 20 30 40 50 60
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370
pF1KSD KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1330 1340 1350 1360 1370
>>XP_005271527 (OMIM: 612834) PREDICTED: pleckstrin homo (1423 aa)
initn: 9054 init1: 9054 opt: 9054 Z-score: 3851.0 bits: 725.0 E(85289): 9.2e-208
Smith-Waterman score: 9054; 100.0% identity (100.0% similar) in 1377 aa overlap (1-1377:47-1423)
10 20 30
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910 920 930
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
920 930 940 950 960 970
940 950 960 970 980 990
pF1KSD MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
980 990 1000 1010 1020 1030
1000 1010 1020 1030 1040 1050
pF1KSD SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
1040 1050 1060 1070 1080 1090
1060 1070 1080 1090 1100 1110
pF1KSD RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
1100 1110 1120 1130 1140 1150
1120 1130 1140 1150 1160 1170
pF1KSD TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
1160 1170 1180 1190 1200 1210
1180 1190 1200 1210 1220 1230
pF1KSD REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
1220 1230 1240 1250 1260 1270
1240 1250 1260 1270 1280 1290
pF1KSD EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
1280 1290 1300 1310 1320 1330
1300 1310 1320 1330 1340 1350
pF1KSD VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
1340 1350 1360 1370 1380 1390
1360 1370
pF1KSD VAPSAEAMRIWMDVIVTGAEGYTQFMN
:::::::::::::::::::::::::::
XP_005 VAPSAEAMRIWMDVIVTGAEGYTQFMN
1400 1410 1420
>>XP_005271528 (OMIM: 612834) PREDICTED: pleckstrin homo (1412 aa)
initn: 8666 init1: 8666 opt: 8666 Z-score: 3686.8 bits: 694.6 E(85289): 1.3e-198
Smith-Waterman score: 8950; 99.2% identity (99.2% similar) in 1377 aa overlap (1-1377:47-1412)
10 20 30
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910 920 930
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
920 930 940 950 960 970
940 950 960 970 980 990
pF1KSD MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
980 990 1000 1010 1020 1030
1000 1010 1020 1030 1040 1050
pF1KSD SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
1040 1050 1060 1070 1080 1090
1060 1070 1080 1090 1100 1110
pF1KSD RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
1100 1110 1120 1130 1140 1150
1120 1130 1140 1150 1160 1170
pF1KSD TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
1160 1170 1180 1190 1200 1210
1180 1190 1200 1210 1220 1230
pF1KSD REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
1220 1230 1240 1250 1260 1270
1240 1250 1260 1270 1280 1290
pF1KSD EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
1280 1290 1300 1310 1320 1330
1300 1310 1320 1330 1340 1350
pF1KSD VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
:::::::::::::::::::::::::::::: :::::::::::::::::::
XP_005 VDKHETKLKGVIYFQAIEEVYYDHLRSAAK-----------SPNPALTFCVKTHDRLYYM
1340 1350 1360 1370 1380
1360 1370
pF1KSD VAPSAEAMRIWMDVIVTGAEGYTQFMN
:::::::::::::::::::::::::::
XP_005 VAPSAEAMRIWMDVIVTGAEGYTQFMN
1390 1400 1410
>>XP_006718865 (OMIM: 612834) PREDICTED: pleckstrin homo (1419 aa)
initn: 8010 init1: 5272 opt: 8053 Z-score: 3427.2 bits: 646.6 E(85289): 3.7e-184
Smith-Waterman score: 8535; 93.7% identity (93.7% similar) in 1420 aa overlap (1-1377:47-1419)
10 20 30
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_006 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKE----------------
::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKERAELAAGRRHLEARQA
800 810 820 830 840 850
800 810 820
pF1KSD ---------------------------AEALETETKLFEDLEFQQLERESRVEEERELAG
:::::::::::::::::::::::::::::::::
XP_006 LYAELQTQLDNCPESVREQLQEQLRREAEALETETKLFEDLEFQQLERESRVEEERELAG
860 870 880 890 900 910
830 840 850 860 870 880
pF1KSD QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKL
920 930 940 950 960 970
890 900 910 920 930 940
pF1KSD TVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSP
:::::::::::::::::::::::::
XP_006 TVLERRYHSLTGGRPFPKTTSTLKE-----------------------------------
980 990 1000
950 960 970 980 990 1000
pF1KSD PPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
1010 1020 1030 1040
1010 1020 1030 1040 1050 1060
pF1KSD ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
1050 1060 1070 1080 1090 1100
1070 1080 1090 1100 1110 1120
pF1KSD DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
1110 1120 1130 1140 1150 1160
1130 1140 1150 1160 1170 1180
pF1KSD GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
1170 1180 1190 1200 1210 1220
1190 1200 1210 1220 1230 1240
pF1KSD EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
1230 1240 1250 1260 1270 1280
1250 1260 1270 1280 1290 1300
pF1KSD TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
1290 1300 1310 1320 1330 1340
1310 1320 1330 1340 1350 1360
pF1KSD EEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVT
1350 1360 1370 1380 1390 1400
1370
pF1KSD GAEGYTQFMN
::::::::::
XP_006 GAEGYTQFMN
1410
>>XP_006718866 (OMIM: 612834) PREDICTED: pleckstrin homo (1408 aa)
initn: 7622 init1: 5272 opt: 7665 Z-score: 3263.0 bits: 616.2 E(85289): 5.2e-175
Smith-Waterman score: 8431; 92.9% identity (92.9% similar) in 1420 aa overlap (1-1377:47-1408)
10 20 30
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_006 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKE----------------
::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKERAELAAGRRHLEARQA
800 810 820 830 840 850
800 810 820
pF1KSD ---------------------------AEALETETKLFEDLEFQQLERESRVEEERELAG
:::::::::::::::::::::::::::::::::
XP_006 LYAELQTQLDNCPESVREQLQEQLRREAEALETETKLFEDLEFQQLERESRVEEERELAG
860 870 880 890 900 910
830 840 850 860 870 880
pF1KSD QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKL
920 930 940 950 960 970
890 900 910 920 930 940
pF1KSD TVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSP
:::::::::::::::::::::::::
XP_006 TVLERRYHSLTGGRPFPKTTSTLKE-----------------------------------
980 990 1000
950 960 970 980 990 1000
pF1KSD PPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
1010 1020 1030 1040
1010 1020 1030 1040 1050 1060
pF1KSD ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
1050 1060 1070 1080 1090 1100
1070 1080 1090 1100 1110 1120
pF1KSD DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
1110 1120 1130 1140 1150 1160
1130 1140 1150 1160 1170 1180
pF1KSD GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
1170 1180 1190 1200 1210 1220
1190 1200 1210 1220 1230 1240
pF1KSD EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
1230 1240 1250 1260 1270 1280
1250 1260 1270 1280 1290 1300
pF1KSD TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
1290 1300 1310 1320 1330 1340
1310 1320 1330 1340 1350 1360
pF1KSD EEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVT
::::::::::::: ::::::::::::::::::::::::::::::::::::
XP_006 EEVYYDHLRSAAK-----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVT
1350 1360 1370 1380 1390
1370
pF1KSD GAEGYTQFMN
::::::::::
XP_006 GAEGYTQFMN
1400
>>XP_005271526 (OMIM: 612834) PREDICTED: pleckstrin homo (1427 aa)
initn: 7111 init1: 6808 opt: 7097 Z-score: 3022.5 bits: 571.7 E(85289): 1.3e-161
Smith-Waterman score: 8910; 98.1% identity (98.1% similar) in 1392 aa overlap (1-1377:47-1427)
10 20 30
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910 920 930
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
920 930 940 950 960 970
940 950 960 970 980 990
pF1KSD MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
980 990 1000 1010 1020 1030
1000 1010 1020 1030 1040
pF1KSD SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK----------
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLP
1040 1050 1060 1070 1080 1090
1050 1060 1070 1080 1090
pF1KSD -----GQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TDDPAGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHL
1100 1110 1120 1130 1140 1150
1100 1110 1120 1130 1140 1150
pF1KSD PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKML
1160 1170 1180 1190 1200 1210
1160 1170 1180 1190 1200 1210
pF1KSD KEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQ
1220 1230 1240 1250 1260 1270
1220 1230 1240 1250 1260 1270
pF1KSD FSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKK
1280 1290 1300 1310 1320 1330
1280 1290 1300 1310 1320 1330
pF1KSD RWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNP
::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_005 RWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK-----------SPNP
1340 1350 1360 1370 1380
1340 1350 1360 1370
pF1KSD ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
::::::::::::::::::::::::::::::::::::::::::
XP_005 ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1390 1400 1410 1420
>>XP_005271525 (OMIM: 612834) PREDICTED: pleckstrin homo (1438 aa)
initn: 6808 init1: 6808 opt: 6833 Z-score: 2910.6 bits: 551.1 E(85289): 2.2e-155
Smith-Waterman score: 9014; 98.9% identity (98.9% similar) in 1392 aa overlap (1-1377:47-1438)
10 20 30
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910 920 930
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
920 930 940 950 960 970
940 950 960 970 980 990
pF1KSD MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
980 990 1000 1010 1020 1030
1000 1010 1020 1030 1040
pF1KSD SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK----------
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLP
1040 1050 1060 1070 1080 1090
1050 1060 1070 1080 1090
pF1KSD -----GQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TDDPAGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHL
1100 1110 1120 1130 1140 1150
1100 1110 1120 1130 1140 1150
pF1KSD PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKML
1160 1170 1180 1190 1200 1210
1160 1170 1180 1190 1200 1210
pF1KSD KEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQ
1220 1230 1240 1250 1260 1270
1220 1230 1240 1250 1260 1270
pF1KSD FSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKK
1280 1290 1300 1310 1320 1330
1280 1290 1300 1310 1320 1330
pF1KSD RWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNP
1340 1350 1360 1370 1380 1390
1340 1350 1360 1370
pF1KSD ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
::::::::::::::::::::::::::::::::::::::::::
XP_005 ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1400 1410 1420 1430
>>XP_011541009 (OMIM: 612834) PREDICTED: pleckstrin homo (1543 aa)
initn: 6030 init1: 6030 opt: 6080 Z-score: 2591.4 bits: 492.1 E(85289): 1.3e-137
Smith-Waterman score: 8206; 91.5% identity (91.5% similar) in 1409 aa overlap (1-1289:47-1455)
10 20 30
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_011 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
::::::::::::::::::::::::::::::::::::::::::
XP_011 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEAELLISESSEMGLGTKAL
920 930 940 950 960 970
pF1KSD ------------------------------------------------------------
XP_011 GLFPGSSQAGASSVSLTPPASTLLCPKAQEYVMLEQLKVMRGTSPMPPAPVPGLSPWASA
980 990 1000 1010 1020 1030
920 930 940
pF1KSD ---------------------------MEKLLLPAVDLEQWYQELMAGLGTGPAAASPHS
:::::::::::::::::::::::::::::::::
XP_011 SRDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHS
1040 1050 1060 1070 1080 1090
950 960 970 980 990 1000
pF1KSD SPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
1100 1110 1120 1130 1140 1150
1010 1020 1030 1040 1050
pF1KSD KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK---------------GQQVIEEQRR
::::::::::::::::::::::::::::::::::: ::::::::::
XP_011 KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDDPAGQQVIEEQRR
1160 1170 1180 1190 1200 1210
1060 1070 1080 1090 1100 1110
pF1KSD RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
1220 1230 1240 1250 1260 1270
1120 1130 1140 1150 1160 1170
pF1KSD TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
1280 1290 1300 1310 1320 1330
1180 1190 1200 1210 1220 1230
pF1KSD REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
1340 1350 1360 1370 1380 1390
1240 1250 1260 1270 1280 1290
pF1KSD EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
1400 1410 1420 1430 1440 1450
1300 1310 1320 1330 1340 1350
pF1KSD VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
XP_011 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
1460 1470 1480 1490 1500 1510
>--
initn: 588 init1: 588 opt: 588 Z-score: 266.4 bits: 61.9 E(85289): 4.3e-08
Smith-Waterman score: 588; 100.0% identity (100.0% similar) in 88 aa overlap (1290-1377:1456-1543)
1260 1270 1280 1290 1300 1310
pF1KSD RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAA
::::::::::::::::::::::::::::::
XP_011 RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAA
1430 1440 1450 1460 1470 1480
1320 1330 1340 1350 1360 1370
pF1KSD KKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1490 1500 1510 1520 1530 1540
>>XP_016872896 (OMIM: 612834) PREDICTED: pleckstrin homo (1542 aa)
initn: 6011 init1: 4917 opt: 6063 Z-score: 2584.2 bits: 490.8 E(85289): 3.3e-137
Smith-Waterman score: 8189; 91.4% identity (91.4% similar) in 1409 aa overlap (1-1289:47-1454)
10 20 30
pF1KSD MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_016 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGPPYSPVP-ESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KSD LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KSD ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KSD VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KSD PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KSD CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KSD ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KSD QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910
pF1KSD RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
::::::::::::::::::::::::::::::::::::::::::
XP_016 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEAELLISESSEMGLGTKAL
920 930 940 950 960 970
pF1KSD ------------------------------------------------------------
XP_016 GLFPGSSQAGASSVSLTPPASTLLCPKAQEYVMLEQLKVMRGTSPMPPAPVPGLSPWASA
980 990 1000 1010 1020 1030
920 930 940
pF1KSD ---------------------------MEKLLLPAVDLEQWYQELMAGLGTGPAAASPHS
:::::::::::::::::::::::::::::::::
XP_016 SRDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHS
1040 1050 1060 1070 1080 1090
950 960 970 980 990 1000
pF1KSD SPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
1100 1110 1120 1130 1140 1150
1010 1020 1030 1040 1050
pF1KSD KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK---------------GQQVIEEQRR
::::::::::::::::::::::::::::::::::: ::::::::::
XP_016 KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDDPAGQQVIEEQRR
1160 1170 1180 1190 1200 1210
1060 1070 1080 1090 1100 1110
pF1KSD RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
1220 1230 1240 1250 1260 1270
1120 1130 1140 1150 1160 1170
pF1KSD TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
1280 1290 1300 1310 1320 1330
1180 1190 1200 1210 1220 1230
pF1KSD REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
1340 1350 1360 1370 1380 1390
1240 1250 1260 1270 1280 1290
pF1KSD EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
1400 1410 1420 1430 1440 1450
1300 1310 1320 1330 1340 1350
pF1KSD VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
XP_016 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
1460 1470 1480 1490 1500 1510
>--
initn: 588 init1: 588 opt: 588 Z-score: 266.4 bits: 61.9 E(85289): 4.2e-08
Smith-Waterman score: 588; 100.0% identity (100.0% similar) in 88 aa overlap (1290-1377:1455-1542)
1260 1270 1280 1290 1300 1310
pF1KSD RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAA
::::::::::::::::::::::::::::::
XP_016 RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAA
1430 1440 1450 1460 1470 1480
1320 1330 1340 1350 1360 1370
pF1KSD KKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1490 1500 1510 1520 1530 1540
1377 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 02:25:39 2016 done: Thu Nov 3 02:25:41 2016
Total Scan time: 15.170 Total Display time: 0.660
Function used was FASTA [36.3.4 Apr, 2011]