Result of FASTA (omim) for
pFN21AA1625
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1625, 757 aa
1>>>pF1KA1625 757 - 757 aa - 757 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.7561+/-0.000449; mu= 13.3330+/- 0.028
mean_var=148.3703+/-30.618, 0's: 0 Z-trim(115.0): 353 B-trim: 381 in 1/55
Lambda= 0.105293
statistics sampled from 24722 (25147) to 24722 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.661), E-opt: 0.2 (0.295), width: 16
Scan time: 10.980
The best scores are: opt bits E(85289)
NP_065162 (OMIM: 605568) E3 ubiquitin-protein liga ( 757) 5212 804.6 0
XP_016867946 (OMIM: 605568) PREDICTED: E3 ubiquiti ( 754) 5178 799.5 0
NP_073576 (OMIM: 605532) E3 ubiquitin-protein liga ( 748) 3539 550.5 9.4e-156
XP_011523430 (OMIM: 605532) PREDICTED: E3 ubiquiti ( 750) 3465 539.2 2.3e-152
XP_005257642 (OMIM: 605532) PREDICTED: E3 ubiquiti ( 735) 3370 524.8 4.9e-148
NP_851994 (OMIM: 605568) E3 ubiquitin-protein liga ( 731) 3194 498.1 5.5e-140
NP_001186776 (OMIM: 605568) E3 ubiquitin-protein l ( 728) 3160 492.9 2e-138
XP_016868486 (OMIM: 602307) PREDICTED: NEDD4-like ( 719) 1475 236.9 2.2e-61
XP_011515104 (OMIM: 602307) PREDICTED: NEDD4-like ( 898) 1475 237.0 2.6e-61
XP_016868483 (OMIM: 602307) PREDICTED: NEDD4-like ( 898) 1475 237.0 2.6e-61
XP_006722487 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 790) 1460 234.7 1.1e-60
XP_016881165 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 856) 1460 234.7 1.2e-60
XP_006722493 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 872) 1460 234.7 1.2e-60
XP_006722484 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 940) 1460 234.8 1.3e-60
XP_005266715 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 960) 1460 234.8 1.3e-60
XP_016881167 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 973) 1460 234.8 1.3e-60
XP_006722491 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 993) 1460 234.8 1.3e-60
XP_011524189 (OMIM: 606384) PREDICTED: E3 ubiquiti (1011) 1460 234.8 1.4e-60
XP_006722489 (OMIM: 606384) PREDICTED: E3 ubiquiti (1019) 1460 234.8 1.4e-60
XP_005260627 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 1403 226.0 4.2e-58
XP_011527381 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 1403 226.0 4.2e-58
NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-pr ( 752) 1403 226.0 4.5e-58
XP_016883580 (OMIM: 606409,613385) PREDICTED: E3 u ( 752) 1403 226.0 4.5e-58
NP_001311127 (OMIM: 606409,613385) E3 ubiquitin-pr ( 862) 1403 226.1 4.9e-58
NP_113671 (OMIM: 606409,613385) E3 ubiquitin-prote ( 862) 1403 226.1 4.9e-58
XP_016883579 (OMIM: 606409,613385) PREDICTED: E3 u ( 900) 1403 226.1 5.1e-58
XP_016883578 (OMIM: 606409,613385) PREDICTED: E3 u ( 903) 1403 226.1 5.1e-58
NP_001244066 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 1403 226.1 5.1e-58
NP_001311126 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 1403 226.1 5.1e-58
NP_955456 (OMIM: 602308) NEDD4-like E3 ubiquitin-p ( 431) 1375 221.5 5.7e-57
NP_001257382 (OMIM: 602308) NEDD4-like E3 ubiquiti ( 754) 1375 221.8 8.5e-57
XP_011521128 (OMIM: 602308) PREDICTED: NEDD4-like ( 754) 1375 221.8 8.5e-57
NP_001257383 (OMIM: 602308) NEDD4-like E3 ubiquiti ( 870) 1375 221.8 9.4e-57
XP_011521127 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 1375 221.8 9.4e-57
XP_011521125 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 1375 221.8 9.4e-57
XP_016878369 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 1375 221.8 9.4e-57
XP_016878370 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 1375 221.8 9.4e-57
NP_008945 (OMIM: 602308) NEDD4-like E3 ubiquitin-p ( 870) 1375 221.8 9.4e-57
XP_016878368 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 1375 221.8 9.4e-57
XP_016868484 (OMIM: 602307) PREDICTED: NEDD4-like ( 743) 1368 220.7 1.8e-56
XP_016868485 (OMIM: 602307) PREDICTED: NEDD4-like ( 743) 1368 220.7 1.8e-56
XP_005250818 (OMIM: 602307) PREDICTED: NEDD4-like ( 921) 1368 220.8 2.1e-56
XP_016868482 (OMIM: 602307) PREDICTED: NEDD4-like ( 921) 1368 220.8 2.1e-56
XP_005250817 (OMIM: 602307) PREDICTED: NEDD4-like ( 922) 1368 220.8 2.1e-56
NP_008944 (OMIM: 602307) NEDD4-like E3 ubiquitin-p ( 922) 1368 220.8 2.1e-56
XP_016881170 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 684) 1348 217.6 1.4e-55
XP_016881169 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 750) 1348 217.7 1.5e-55
XP_006722488 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 772) 1348 217.7 1.5e-55
NP_001138442 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 1348 217.7 1.6e-55
NP_001138443 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 1348 217.7 1.6e-55
>>NP_065162 (OMIM: 605568) E3 ubiquitin-protein ligase S (757 aa)
initn: 5212 init1: 5212 opt: 5212 Z-score: 4290.7 bits: 804.6 E(85289): 0
Smith-Waterman score: 5212; 100.0% identity (100.0% similar) in 757 aa overlap (1-757:1-757)
10 20 30 40 50 60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
670 680 690 700 710 720
730 740 750
pF1KA1 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
:::::::::::::::::::::::::::::::::::::
NP_065 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
730 740 750
>>XP_016867946 (OMIM: 605568) PREDICTED: E3 ubiquitin-pr (754 aa)
initn: 4820 init1: 4820 opt: 5178 Z-score: 4262.8 bits: 799.5 E(85289): 0
Smith-Waterman score: 5178; 99.6% identity (99.6% similar) in 757 aa overlap (1-757:1-754)
10 20 30 40 50 60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_016 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQG---AAGPRLFTIHLIDANTDNLP
670 680 690 700 710
730 740 750
pF1KA1 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
:::::::::::::::::::::::::::::::::::::
XP_016 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
720 730 740 750
>>NP_073576 (OMIM: 605532) E3 ubiquitin-protein ligase S (748 aa)
initn: 3320 init1: 1983 opt: 3539 Z-score: 2917.3 bits: 550.5 E(85289): 9.4e-156
Smith-Waterman score: 3813; 72.3% identity (83.1% similar) in 792 aa overlap (1-757:1-748)
10 20 30 40 50 60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
::::: :::: .:.::::::::::.:::::::::::::.::::::::::::::::::::
NP_073 MSNPGGRRNGP-VKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDP
10 20 30 40 50
70 80 90 100 110 120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
:::::::::.::.::.:::::::::::::::::::::::::::::.::::::::::::::
NP_073 KWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCK
60 70 80 90 100 110
130 140 150 160
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENE------------GTVY-----
:.:.:.:.::::::::::.::::::::.:::: :..:. : .
NP_073 LGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHI
120 130 140 150 160 170
170 180 190 200
pF1KA1 --------------EDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQA
: :.::::::::..: .: . ..::. : :.: ::
NP_073 TRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCG---------QSSDPRLAE
180 190 200 210 220 230
210 220 230 240 250 260
pF1KA1 QRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS
.:.:. :. . .: : : :.:::::::::: ::::::::::::::::::::.:
NP_073 RRVRSQRHRNYM----SRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP-
240 250 260 270 280
270 280 290 300 310 320
pF1KA1 PSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNN
:::...::.::::::::::.:.:..::.:::::::
NP_073 -------------------------RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNN
290 300 310 320
330 340 350 360 370 380
pF1KA1 RTTQFTDPRL----HHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVL
:::::::::: : ..:.: :::. .: . : . : : . ::.::::::::.:
NP_073 RTTQFTDPRLSANLHLVLNRQNQLKDQQQQ-QVVSLCPDDTECLTVPRYKRDLVQKLKIL
330 340 350 360 370
390 400 410 420 430 440
pF1KA1 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAR
:.::: ::::::::::::::::::::::::.:::::::: ::::.:::::::::::::::
NP_073 RQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR
380 390 400 410 420 430
450 460 470 480 490 500
pF1KA1 EWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHY
:::::: :::::::::::::: :.:: :::::::..::.:::::::::::::.:::::::
NP_073 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY
440 450 460 470 480 490
510 520 530 540 550 560
pF1KA1 INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRI
:.::::.::::::::: : :.:.: :::.::.::::::::::: ::::::::::::.:.:
NP_073 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEI
500 510 520 530 540 550
570 580 590 600 610 620
pF1KA1 LQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQ
.::::::::...::.::::::::::::::::.::::::::::::::::.::::::: ::.
NP_073 IQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDE
560 570 580 590 600 610
630 640 650 660 670 680
pF1KA1 KELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGST
::::::: :: :::.:::: :::::::. :::::.:::.::: ::::::::::::::::.
NP_073 KELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSS
620 630 640 650 660 670
690 700 710 720 730 740
pF1KA1 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL
:::::::::::: :::::::::: ::: :.::::::::::::::::::::::::::::
NP_073 RVPLQGFKALQG---AAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLL
680 690 700 710 720 730
750
pF1KA1 TAVEETCGFAVE
::.:::::::::
NP_073 TAIEETCGFAVE
740
>>XP_011523430 (OMIM: 605532) PREDICTED: E3 ubiquitin-pr (750 aa)
initn: 3286 init1: 1983 opt: 3465 Z-score: 2856.5 bits: 539.2 E(85289): 2.3e-152
Smith-Waterman score: 3739; 71.1% identity (82.6% similar) in 793 aa overlap (1-757:1-750)
10 20 30 40 50
pF1KA1 MSNPGTRRNGSSIKIRLT-VLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLD
:. . :...:.. . : :::::::.:::::::::::::.:::::::::::::::::::
XP_011 MGLSSCRKTSSGLPLILHYVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 PKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLC
::::::::::.::.::.:::::::::::::::::::::::::::::.:::::::::::::
XP_011 PKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLC
70 80 90 100 110 120
120 130 140 150 160
pF1KA1 KLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENE------------GTVY----
::.:.:.:.::::::::::.::::::::.:::: :..:. : .
XP_011 KLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNH
130 140 150 160 170 180
170 180 190 200
pF1KA1 ---------------EDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQ
: :.::::::::..: .: . ..::. : :.: ::
XP_011 ITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCG---------QSSDPRLA
190 200 210 220 230
210 220 230 240 250 260
pF1KA1 AQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP
.:.:. :. . .: : : :.:::::::::: ::::::::::::::::::::.:
XP_011 ERRVRSQRHRNYM----SRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP
240 250 260 270 280
270 280 290 300 310 320
pF1KA1 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN
:::...::.::::::::::.:.:..::.::::::
XP_011 --------------------------RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHN
290 300 310 320
330 340 350 360 370 380
pF1KA1 NRTTQFTDPRL----HHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKV
::::::::::: : ..:.: :::. .: . : . : : . ::.::::::::.
XP_011 NRTTQFTDPRLSANLHLVLNRQNQLKDQQQQ-QVVSLCPDDTECLTVPRYKRDLVQKLKI
330 340 350 360 370 380
390 400 410 420 430 440
pF1KA1 LRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVA
::.::: ::::::::::::::::::::::::.:::::::: ::::.::::::::::::::
XP_011 LRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVA
390 400 410 420 430 440
450 460 470 480 490 500
pF1KA1 REWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGH
::::::: :::::::::::::: :.:: :::::::..::.:::::::::::::.::::::
XP_011 REWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGH
450 460 470 480 490 500
510 520 530 540 550 560
pF1KA1 YINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGR
::.::::.::::::::: : :.:.: :::.::.::::::::::: ::::::::::::.:.
XP_011 YIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGE
510 520 530 540 550 560
570 580 590 600 610 620
pF1KA1 ILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFD
:.::::::::...::.::::::::::::::::.::::::::::::::::.::::::: ::
XP_011 IIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFD
570 580 590 600 610 620
630 640 650 660 670 680
pF1KA1 QKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGS
.::::::: :: :::.:::: :::::::. :::::.:::.::: ::::::::::::::::
XP_011 EKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGS
630 640 650 660 670 680
690 700 710 720 730 740
pF1KA1 TRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKL
.:::::::::::: :::::::::: ::: :.:::::::::::::::::::::::::::
XP_011 SRVPLQGFKALQG---AAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKL
690 700 710 720 730
750
pF1KA1 LTAVEETCGFAVE
:::.:::::::::
XP_011 LTAIEETCGFAVE
740 750
>>XP_005257642 (OMIM: 605532) PREDICTED: E3 ubiquitin-pr (735 aa)
initn: 3247 init1: 1983 opt: 3370 Z-score: 2778.6 bits: 524.8 E(85289): 4.9e-148
Smith-Waterman score: 3685; 70.7% identity (81.3% similar) in 792 aa overlap (1-757:1-735)
10 20 30 40 50 60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
::::: :::: .:.::: :::::::.::::::::::::::::::::
XP_005 MSNPGGRRNGP-VKLRLT-------------GLPDPFAKVVVDGSGQCHSTDTVKNTLDP
10 20 30 40
70 80 90 100 110 120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
:::::::::.::.::.:::::::::::::::::::::::::::::.::::::::::::::
XP_005 KWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCK
50 60 70 80 90 100
130 140 150 160
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENE------------GTVY-----
:.:.:.:.::::::::::.::::::::.:::: :..:. : .
XP_005 LGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHI
110 120 130 140 150 160
170 180 190 200
pF1KA1 --------------EDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQA
: :.::::::::..: .: . ..::. : :.: ::
XP_005 TRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCG---------QSSDPRLAE
170 180 190 200 210
210 220 230 240 250 260
pF1KA1 QRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS
.:.:. :. . .: : : :.:::::::::: ::::::::::::::::::::.:
XP_005 RRVRSQRHRNYM----SRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP-
220 230 240 250 260 270
270 280 290 300 310 320
pF1KA1 PSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNN
:::...::.::::::::::.:.:..::.:::::::
XP_005 -------------------------RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNN
280 290 300
330 340 350 360 370 380
pF1KA1 RTTQFTDPRL----HHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVL
:::::::::: : ..:.: :::. .: . : . : : . ::.::::::::.:
XP_005 RTTQFTDPRLSANLHLVLNRQNQLKDQQQQ-QVVSLCPDDTECLTVPRYKRDLVQKLKIL
310 320 330 340 350 360
390 400 410 420 430 440
pF1KA1 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAR
:.::: ::::::::::::::::::::::::.:::::::: ::::.:::::::::::::::
XP_005 RQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR
370 380 390 400 410 420
450 460 470 480 490 500
pF1KA1 EWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHY
:::::: :::::::::::::: :.:: :::::::..::.:::::::::::::.:::::::
XP_005 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY
430 440 450 460 470 480
510 520 530 540 550 560
pF1KA1 INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRI
:.::::.::::::::: : :.:.: :::.::.::::::::::: ::::::::::::.:.:
XP_005 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEI
490 500 510 520 530 540
570 580 590 600 610 620
pF1KA1 LQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQ
.::::::::...::.::::::::::::::::.::::::::::::::::.::::::: ::.
XP_005 IQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDE
550 560 570 580 590 600
630 640 650 660 670 680
pF1KA1 KELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGST
::::::: :: :::.:::: :::::::. :::::.:::.::: ::::::::::::::::.
XP_005 KELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSS
610 620 630 640 650 660
690 700 710 720 730 740
pF1KA1 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL
:::::::::::: :::::::::: ::: :.::::::::::::::::::::::::::::
XP_005 RVPLQGFKALQG---AAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLL
670 680 690 700 710 720
750
pF1KA1 TAVEETCGFAVE
::.:::::::::
XP_005 TAIEETCGFAVE
730
>>NP_851994 (OMIM: 605568) E3 ubiquitin-protein ligase S (731 aa)
initn: 3194 init1: 3194 opt: 3194 Z-score: 2634.2 bits: 498.1 E(85289): 5.5e-140
Smith-Waterman score: 4972; 96.6% identity (96.6% similar) in 757 aa overlap (1-757:1-731)
10 20 30 40 50 60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
:::::::::::::::::::::::::::: ::::::
NP_851 EQRTTVQGQVYFLHTQTGVSTWHDPRIP--------------------------RDLNSV
250 260 270
310 320 330 340 350 360
pF1KA1 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KA1 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
340 350 360 370 380 390
430 440 450 460 470 480
pF1KA1 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
400 410 420 430 440 450
490 500 510 520 530 540
pF1KA1 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
460 470 480 490 500 510
550 560 570 580 590 600
pF1KA1 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
520 530 540 550 560 570
610 620 630 640 650 660
pF1KA1 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
580 590 600 610 620 630
670 680 690 700 710 720
pF1KA1 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_851 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
640 650 660 670 680 690
730 740 750
pF1KA1 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
:::::::::::::::::::::::::::::::::::::
NP_851 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
700 710 720 730
>>NP_001186776 (OMIM: 605568) E3 ubiquitin-protein ligas (728 aa)
initn: 2802 init1: 2802 opt: 3160 Z-score: 2606.3 bits: 492.9 E(85289): 2e-138
Smith-Waterman score: 4938; 96.2% identity (96.2% similar) in 757 aa overlap (1-757:1-728)
10 20 30 40 50 60
pF1KA1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
:::::::::::::::::::::::::::: ::::::
NP_001 EQRTTVQGQVYFLHTQTGVSTWHDPRIP--------------------------RDLNSV
250 260 270
310 320 330 340 350 360
pF1KA1 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KA1 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
340 350 360 370 380 390
430 440 450 460 470 480
pF1KA1 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
400 410 420 430 440 450
490 500 510 520 530 540
pF1KA1 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
460 470 480 490 500 510
550 560 570 580 590 600
pF1KA1 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
520 530 540 550 560 570
610 620 630 640 650 660
pF1KA1 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
580 590 600 610 620 630
670 680 690 700 710 720
pF1KA1 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
NP_001 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQG---AAGPRLFTIHLIDANTDNLP
640 650 660 670 680 690
730 740 750
pF1KA1 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
:::::::::::::::::::::::::::::::::::::
NP_001 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
700 710 720
>>XP_016868486 (OMIM: 602307) PREDICTED: NEDD4-like E3 u (719 aa)
initn: 1515 init1: 602 opt: 1475 Z-score: 1223.0 bits: 236.9 E(85289): 2.2e-61
Smith-Waterman score: 1502; 40.1% identity (66.5% similar) in 633 aa overlap (156-757:124-719)
130 140 150 160 170
pF1KA1 TDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEG-TVYE-DSGPGRPLSCFM----EEP
::.:. .. : :.. .: : : ..:
XP_016 CTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQP
100 110 120 130 140 150
180 190 200 210 220 230
pF1KA1 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPE-LPE
: . .:..: . . : . .:: ..: : ..: . :. ::
XP_016 DGCMDPVRQQSGNANTETLPS-GWEQR------KDPHGRTYYVDHNTRTTTWERPQPLPP
160 170 180 190 200
240 250 260 270 280
pF1KA1 GYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS---------PSGTIPGGDAAFLYEFLLQG
:.:.:. . .::.. .: ..::. : . : . . :. : ..: ..
XP_016 GWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSA
210 220 230 240 250 260
290 300 310 320 330 340
pF1KA1 HTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL
.. ... : :::::::: : . :.:::.::..:::. ::: . ..:..
XP_016 ------SMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEE---
270 280 290 300 310
350 360 370 380 390 400
pF1KA1 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHEL---SLQQPQAGHCRIEVSRE
::: : :. :: :. :. . . :. ....:. :. . .
XP_016 -------PLP-----EGWEI---RYTREGVRYF--VDHNTRTTTFKDPRNGKSSVTKGGP
320 330 340 350 360
410 420 430 440 450
pF1KA1 EI-FEESYR----------QIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEM
.: .:...: ::: ..: ::..::.: :::::::::::.::::..:: ::.
XP_016 QIAYERGFRWKLAHFRYLCQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEV
370 380 390 400 410 420
460 470 480 490 500 510
pF1KA1 LNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFY
:::.: ::.:. : : ::::: :.::::::::: :.::....:.:::..:. ::..:::
XP_016 LNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFY
430 440 450 460 470 480
520 530 540 550 560 570
pF1KA1 KQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNG
:..:.: . ..::::.: :...::.:: .:.: :. : :. . .:.. .:.:: .:
XP_016 KRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGG
490 500 510 520 530 540
580 590 600 610 620 630
pF1KA1 RNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGG
:. :::::: ::. :...::: ::.. : :. ::::..: . :. ::.::::... :
XP_016 SNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCG
550 560 570 580 590 600
640 650 660 670 680 690
pF1KA1 LDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKA
....:: ::. :: .: . .:. . :::: :. :.: : ::::::::. :.:: ::
XP_016 MQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAE
610 620 630 640 650 660
700 710 720 730 740 750
pF1KA1 LQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF
:.::.: :. : :. . .: ::..::::::.:.:::.:::.: :::: :.::: ::
XP_016 LMGSNG---PQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
670 680 690 700 710
pF1KA1 AVE
. :
XP_016 GQE
>>XP_011515104 (OMIM: 602307) PREDICTED: NEDD4-like E3 u (898 aa)
initn: 1515 init1: 602 opt: 1475 Z-score: 1221.8 bits: 237.0 E(85289): 2.6e-61
Smith-Waterman score: 1502; 40.1% identity (66.5% similar) in 633 aa overlap (156-757:303-898)
130 140 150 160 170
pF1KA1 TDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEG-TVYE-DSGPGRPLSCFM----EEP
::.:. .. : :.. .: : : ..:
XP_011 CTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQP
280 290 300 310 320 330
180 190 200 210 220 230
pF1KA1 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPE-LPE
: . .:..: . . : . .:: ..: : ..: . :. ::
XP_011 DGCMDPVRQQSGNANTETLPS-GWEQR------KDPHGRTYYVDHNTRTTTWERPQPLPP
340 350 360 370 380
240 250 260 270 280
pF1KA1 GYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS---------PSGTIPGGDAAFLYEFLLQG
:.:.:. . .::.. .: ..::. : . : . . :. : ..: ..
XP_011 GWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSA
390 400 410 420 430 440
290 300 310 320 330 340
pF1KA1 HTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL
.. ... : :::::::: : . :.:::.::..:::. ::: . ..:..
XP_011 ------SMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEE---
450 460 470 480 490
350 360 370 380 390 400
pF1KA1 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHEL---SLQQPQAGHCRIEVSRE
::: : :. :: :. :. . . :. ....:. :. . .
XP_011 -------PLP-----EGWEI---RYTREGVRYF--VDHNTRTTTFKDPRNGKSSVTKGGP
500 510 520 530
410 420 430 440 450
pF1KA1 EI-FEESYR----------QIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEM
.: .:...: ::: ..: ::..::.: :::::::::::.::::..:: ::.
XP_011 QIAYERGFRWKLAHFRYLCQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEV
540 550 560 570 580 590
460 470 480 490 500 510
pF1KA1 LNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFY
:::.: ::.:. : : ::::: :.::::::::: :.::....:.:::..:. ::..:::
XP_011 LNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFY
600 610 620 630 640 650
520 530 540 550 560 570
pF1KA1 KQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNG
:..:.: . ..::::.: :...::.:: .:.: :. : :. . .:.. .:.:: .:
XP_011 KRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGG
660 670 680 690 700 710
580 590 600 610 620 630
pF1KA1 RNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGG
:. :::::: ::. :...::: ::.. : :. ::::..: . :. ::.::::... :
XP_011 SNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCG
720 730 740 750 760 770
640 650 660 670 680 690
pF1KA1 LDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKA
....:: ::. :: .: . .:. . :::: :. :.: : ::::::::. :.:: ::
XP_011 MQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAE
780 790 800 810 820 830
700 710 720 730 740 750
pF1KA1 LQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF
:.::.: :. : :. . .: ::..::::::.:.:::.:::.: :::: :.::: ::
XP_011 LMGSNG---PQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
840 850 860 870 880 890
pF1KA1 AVE
. :
XP_011 GQE
>>XP_016868483 (OMIM: 602307) PREDICTED: NEDD4-like E3 u (898 aa)
initn: 1515 init1: 602 opt: 1475 Z-score: 1221.8 bits: 237.0 E(85289): 2.6e-61
Smith-Waterman score: 1502; 40.1% identity (66.5% similar) in 633 aa overlap (156-757:303-898)
130 140 150 160 170
pF1KA1 TDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEG-TVYE-DSGPGRPLSCFM----EEP
::.:. .. : :.. .: : : ..:
XP_016 CTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQP
280 290 300 310 320 330
180 190 200 210 220 230
pF1KA1 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPE-LPE
: . .:..: . . : . .:: ..: : ..: . :. ::
XP_016 DGCMDPVRQQSGNANTETLPS-GWEQR------KDPHGRTYYVDHNTRTTTWERPQPLPP
340 350 360 370 380
240 250 260 270 280
pF1KA1 GYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS---------PSGTIPGGDAAFLYEFLLQG
:.:.:. . .::.. .: ..::. : . : . . :. : ..: ..
XP_016 GWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSA
390 400 410 420 430 440
290 300 310 320 330 340
pF1KA1 HTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL
.. ... : :::::::: : . :.:::.::..:::. ::: . ..:..
XP_016 ------SMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEE---
450 460 470 480 490
350 360 370 380 390 400
pF1KA1 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHEL---SLQQPQAGHCRIEVSRE
::: : :. :: :. :. . . :. ....:. :. . .
XP_016 -------PLP-----EGWEI---RYTREGVRYF--VDHNTRTTTFKDPRNGKSSVTKGGP
500 510 520 530
410 420 430 440 450
pF1KA1 EI-FEESYR----------QIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEM
.: .:...: ::: ..: ::..::.: :::::::::::.::::..:: ::.
XP_016 QIAYERGFRWKLAHFRYLCQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEV
540 550 560 570 580 590
460 470 480 490 500 510
pF1KA1 LNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFY
:::.: ::.:. : : ::::: :.::::::::: :.::....:.:::..:. ::..:::
XP_016 LNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFY
600 610 620 630 640 650
520 530 540 550 560 570
pF1KA1 KQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNG
:..:.: . ..::::.: :...::.:: .:.: :. : :. . .:.. .:.:: .:
XP_016 KRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGG
660 670 680 690 700 710
580 590 600 610 620 630
pF1KA1 RNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGG
:. :::::: ::. :...::: ::.. : :. ::::..: . :. ::.::::... :
XP_016 SNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCG
720 730 740 750 760 770
640 650 660 670 680 690
pF1KA1 LDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKA
....:: ::. :: .: . .:. . :::: :. :.: : ::::::::. :.:: ::
XP_016 MQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAE
780 790 800 810 820 830
700 710 720 730 740 750
pF1KA1 LQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF
:.::.: :. : :. . .: ::..::::::.:.:::.:::.: :::: :.::: ::
XP_016 LMGSNG---PQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
840 850 860 870 880 890
pF1KA1 AVE
. :
XP_016 GQE
757 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 21:35:25 2016 done: Wed Nov 2 21:35:27 2016
Total Scan time: 10.980 Total Display time: 0.160
Function used was FASTA [36.3.4 Apr, 2011]