Result of FASTA (omim) for
pFN21AA0321
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0321, 2539 aa
1>>>pF1KA0321 2539 - 2539 aa - 2539 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.9173+/-0.000435; mu= 14.1110+/- 0.027
mean_var=147.6979+/-30.365, 0's: 0 Z-trim(115.7): 136 B-trim: 348 in 1/54
Lambda= 0.105533
statistics sampled from 26182 (26331) to 26182 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.309), width: 16
Scan time: 24.400
The best scores are: opt bits E(85289)
NP_056161 (OMIM: 270700,612012) zinc finger FYVE d (2539) 17027 2605.9 0
XP_016876613 (OMIM: 270700,612012) PREDICTED: zinc (2545) 17005 2602.6 0
XP_016876614 (OMIM: 270700,612012) PREDICTED: zinc (2503) 16564 2535.4 0
XP_016876615 (OMIM: 270700,612012) PREDICTED: zinc (2042) 13531 2073.6 0
XP_016876616 (OMIM: 270700,612012) PREDICTED: zinc (1770) 11685 1792.5 0
XP_016876617 (OMIM: 270700,612012) PREDICTED: zinc (1739) 11511 1766.0 0
XP_011534911 (OMIM: 270700,612012) PREDICTED: zinc (1666) 11130 1708.0 0
XP_011525611 (OMIM: 615200) PREDICTED: pleckstrin ( 279) 283 56.1 7.8e-07
NP_077286 (OMIM: 615200) pleckstrin homology domai ( 279) 283 56.1 7.8e-07
XP_005259313 (OMIM: 615200) PREDICTED: pleckstrin ( 364) 283 56.2 9.7e-07
NP_078889 (OMIM: 615208) pleckstrin homology domai ( 249) 273 54.6 2e-06
NP_060821 (OMIM: 613520) FYVE, RhoGEF and PH domai (1430) 268 54.2 1.5e-05
NP_775829 (OMIM: 605091) FYVE, RhoGEF and PH domai ( 655) 233 48.7 0.00031
NP_001098721 (OMIM: 608880) zinc finger FYVE domai (1539) 233 48.9 0.00063
NP_055548 (OMIM: 608880) zinc finger FYVE domain-c (1539) 233 48.9 0.00063
XP_016865580 (OMIM: 608880) PREDICTED: zinc finger (1539) 233 48.9 0.00063
XP_011542055 (OMIM: 608880) PREDICTED: zinc finger (1539) 233 48.9 0.00063
XP_005248689 (OMIM: 608880) PREDICTED: zinc finger (1539) 233 48.9 0.00063
XP_016865581 (OMIM: 608880) PREDICTED: zinc finger (1539) 233 48.9 0.00063
NP_001271165 (OMIM: 608880) zinc finger FYVE domai (1539) 233 48.9 0.00063
NP_001271166 (OMIM: 608880) zinc finger FYVE domai ( 809) 227 47.8 0.0007
XP_016863994 (OMIM: 614176) PREDICTED: lateral sig ( 773) 219 46.6 0.0016
NP_001166130 (OMIM: 614176) lateral signaling targ ( 817) 219 46.6 0.0016
NP_001166127 (OMIM: 614176) lateral signaling targ ( 857) 219 46.6 0.0017
NP_066023 (OMIM: 614176) lateral signaling target ( 887) 219 46.6 0.0017
XP_016865384 (OMIM: 610327) PREDICTED: RUN and FYV ( 310) 210 45.0 0.0019
XP_016865383 (OMIM: 610327) PREDICTED: RUN and FYV ( 368) 210 45.1 0.0022
XP_006714985 (OMIM: 610327) PREDICTED: RUN and FYV ( 368) 210 45.1 0.0022
XP_016865382 (OMIM: 610327) PREDICTED: RUN and FYV ( 416) 210 45.1 0.0024
XP_016865381 (OMIM: 610327) PREDICTED: RUN and FYV ( 438) 210 45.1 0.0025
NP_076976 (OMIM: 613504) zinc finger FYVE domain-c ( 234) 205 44.2 0.0025
XP_005266050 (OMIM: 610327) PREDICTED: RUN and FYV ( 465) 210 45.1 0.0026
NP_001185882 (OMIM: 613504) zinc finger FYVE domai ( 252) 205 44.2 0.0027
XP_016865380 (OMIM: 610327) PREDICTED: RUN and FYV ( 578) 210 45.2 0.0032
NP_001035542 (OMIM: 610327) RUN and FYVE domain-co ( 600) 210 45.2 0.0033
NP_001035541 (OMIM: 610327) RUN and FYVE domain-co ( 600) 210 45.2 0.0033
XP_006714984 (OMIM: 610327) PREDICTED: RUN and FYV ( 686) 210 45.2 0.0036
NP_079434 (OMIM: 610327) RUN and FYVE domain-conta ( 708) 210 45.2 0.0037
XP_016880786 (OMIM: 604375) PREDICTED: hepatocyte ( 768) 209 45.1 0.0045
XP_011523765 (OMIM: 604375) PREDICTED: hepatocyte ( 777) 209 45.1 0.0045
NP_004703 (OMIM: 604375) hepatocyte growth factor- ( 777) 209 45.1 0.0045
XP_005270014 (OMIM: 610328) PREDICTED: RUN and FYV ( 572) 206 44.6 0.0048
XP_005270013 (OMIM: 610328) PREDICTED: RUN and FYV ( 585) 206 44.6 0.0049
XP_005270012 (OMIM: 610328) PREDICTED: RUN and FYV ( 590) 206 44.6 0.0049
XP_011538244 (OMIM: 610328) PREDICTED: RUN and FYV ( 606) 206 44.6 0.005
NP_001317032 (OMIM: 610328) RUN and FYVE domain-co ( 606) 206 44.6 0.005
XP_005270010 (OMIM: 610328) PREDICTED: RUN and FYV ( 607) 206 44.6 0.005
NP_060457 (OMIM: 610328) RUN and FYVE domain-conta ( 641) 206 44.6 0.0053
XP_016865918 (OMIM: 605091) PREDICTED: FYVE, RhoGE ( 662) 203 44.1 0.0074
XP_016858334 (OMIM: 603755) PREDICTED: zinc finger (1167) 206 44.7 0.0087
>>NP_056161 (OMIM: 270700,612012) zinc finger FYVE domai (2539 aa)
initn: 17027 init1: 17027 opt: 17027 Z-score: 14006.9 bits: 2605.9 E(85289): 0
Smith-Waterman score: 17027; 99.9% identity (100.0% similar) in 2539 aa overlap (1-2539:1-2539)
10 20 30 40 50 60
pF1KA0 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 DSLSSPGAANLFSTYPARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_056 DSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 RGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_056 RGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA0 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA0 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA0 DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPP
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KA0 ATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENP
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KA0 ARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENE
::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
NP_056 ARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADEVEWILDLKEEENE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KA0 LVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMK
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KA0 QLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRN
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KA0 QLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLN
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KA0 HGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYY
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KA0 QECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTL
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KA0 ENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAK
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KA0 SYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEV
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KA0 TRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQL
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KA0 DAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELE
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KA0 GLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDIC
2470 2480 2490 2500 2510 2520
2530
pF1KA0 AQWLLTSHPRGAHGPGSRK
:::::::::::::::::::
NP_056 AQWLLTSHPRGAHGPGSRK
2530
>>XP_016876613 (OMIM: 270700,612012) PREDICTED: zinc fin (2545 aa)
initn: 11664 init1: 11664 opt: 17005 Z-score: 13988.8 bits: 2602.6 E(85289): 0
Smith-Waterman score: 17005; 99.6% identity (99.7% similar) in 2545 aa overlap (1-2539:1-2545)
10 20 30 40 50 60
pF1KA0 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 DSLSSPGAANLFSTYPARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 RGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_016 RGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA0 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA0 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790
pF1KA0 ------DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFSLSTDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPS
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KA0 QEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVE
1810 1820 1830 1840 1850 1860
1860 1870 1880 1890 1900 1910
pF1KA0 GCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADEVEWILDL
::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
XP_016 GCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADEVEWILDL
1870 1880 1890 1900 1910 1920
1920 1930 1940 1950 1960 1970
pF1KA0 KEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGL
1930 1940 1950 1960 1970 1980
1980 1990 2000 2010 2020 2030
pF1KA0 LTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAA
1990 2000 2010 2020 2030 2040
2040 2050 2060 2070 2080 2090
pF1KA0 VTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPF
2050 2060 2070 2080 2090 2100
2100 2110 2120 2130 2140 2150
pF1KA0 DLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKI
2110 2120 2130 2140 2150 2160
2160 2170 2180 2190 2200 2210
pF1KA0 MNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKS
2170 2180 2190 2200 2210 2220
2220 2230 2240 2250 2260 2270
pF1KA0 GKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRF
2230 2240 2250 2260 2270 2280
2280 2290 2300 2310 2320 2330
pF1KA0 FSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTL
2290 2300 2310 2320 2330 2340
2340 2350 2360 2370 2380 2390
pF1KA0 QLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRV
2350 2360 2370 2380 2390 2400
2400 2410 2420 2430 2440 2450
pF1KA0 LQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRI
2410 2420 2430 2440 2450 2460
2460 2470 2480 2490 2500 2510
pF1KA0 PPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDA
2470 2480 2490 2500 2510 2520
2520 2530
pF1KA0 VVQDICAQWLLTSHPRGAHGPGSRK
:::::::::::::::::::::::::
XP_016 VVQDICAQWLLTSHPRGAHGPGSRK
2530 2540
>>XP_016876614 (OMIM: 270700,612012) PREDICTED: zinc fin (2503 aa)
initn: 16580 init1: 11664 opt: 16564 Z-score: 13626.0 bits: 2535.4 E(85289): 0
Smith-Waterman score: 16564; 99.3% identity (99.4% similar) in 2489 aa overlap (1-2483:1-2489)
10 20 30 40 50 60
pF1KA0 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 DSLSSPGAANLFSTYPARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 RGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_016 RGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA0 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA0 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790
pF1KA0 ------DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFSLSTDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPS
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KA0 QEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVE
1810 1820 1830 1840 1850 1860
1860 1870 1880 1890 1900 1910
pF1KA0 GCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADEVEWILDL
::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
XP_016 GCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADEVEWILDL
1870 1880 1890 1900 1910 1920
1920 1930 1940 1950 1960 1970
pF1KA0 KEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGL
1930 1940 1950 1960 1970 1980
1980 1990 2000 2010 2020 2030
pF1KA0 LTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAA
1990 2000 2010 2020 2030 2040
2040 2050 2060 2070 2080 2090
pF1KA0 VTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPF
2050 2060 2070 2080 2090 2100
2100 2110 2120 2130 2140 2150
pF1KA0 DLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKI
2110 2120 2130 2140 2150 2160
2160 2170 2180 2190 2200 2210
pF1KA0 MNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKS
2170 2180 2190 2200 2210 2220
2220 2230 2240 2250 2260 2270
pF1KA0 GKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRF
2230 2240 2250 2260 2270 2280
2280 2290 2300 2310 2320 2330
pF1KA0 FSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTL
2290 2300 2310 2320 2330 2340
2340 2350 2360 2370 2380 2390
pF1KA0 QLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRV
2350 2360 2370 2380 2390 2400
2400 2410 2420 2430 2440 2450
pF1KA0 LQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRI
2410 2420 2430 2440 2450 2460
2460 2470 2480 2490 2500 2510
pF1KA0 PPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDA
::::::::::::::::::. : . :
XP_016 PPQELEGLIQAIHNDDNKIVPILAALRDRVHTEERGRSPSTLC
2470 2480 2490 2500
>>XP_016876615 (OMIM: 270700,612012) PREDICTED: zinc fin (2042 aa)
initn: 8190 init1: 8190 opt: 13531 Z-score: 11131.7 bits: 2073.6 E(85289): 0
Smith-Waterman score: 13531; 99.6% identity (99.7% similar) in 2042 aa overlap (504-2539:1-2042)
480 490 500 510 520 530
pF1KA0 PQQEPDAVDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLA
::::::::::::::::::::::::::::::
XP_016 MKYAIYALCVNSHQHSQCQDCKDSLSEDLA
10 20 30
540 550 560 570 580 590
pF1KA0 SATEPANDSLSSPGAANLFSTYPARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEP
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_016 SATEPANDSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEP
40 50 60 70 80 90
600 610 620 630 640 650
pF1KA0 HLPEDYAEDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLPEDYAEDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEP
100 110 120 130 140 150
660 670 680 690 700 710
pF1KA0 KDSYPGPHRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDSYPGPHRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQ
160 170 180 190 200 210
720 730 740 750 760 770
pF1KA0 SCSGSRDGLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCSGSRDGLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTR
220 230 240 250 260 270
780 790 800 810 820 830
pF1KA0 RSQADGRDRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSQADGRDRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPP
280 290 300 310 320 330
840 850 860 870 880 890
pF1KA0 ESLLASCILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESLLASCILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSD
340 350 360 370 380 390
900 910 920 930 940 950
pF1KA0 AGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTAL
400 410 420 430 440 450
960 970 980 990 1000 1010
pF1KA0 VEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHV
460 470 480 490 500 510
1020 1030 1040 1050 1060 1070
pF1KA0 LLNADGIRGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLS
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
XP_016 LLNADGIRGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLS
520 530 540 550 560 570
1080 1090 1100 1110 1120 1130
pF1KA0 EDCVASHTTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDCVASHTTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQL
580 590 600 610 620 630
1140 1150 1160 1170 1180 1190
pF1KA0 LQKNLGKQTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQKNLGKQTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSS
640 650 660 670 680 690
1200 1210 1220 1230 1240 1250
pF1KA0 QLVSHLLFERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLVSHLLFERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRL
700 710 720 730 740 750
1260 1270 1280 1290 1300 1310
pF1KA0 GTLAQLHASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTLAQLHASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSK
760 770 780 790 800 810
1320 1330 1340 1350 1360 1370
pF1KA0 LLATVACLGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLATVACLGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAA
820 830 840 850 860 870
1380 1390 1400 1410 1420 1430
pF1KA0 WEPLRGSLQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WEPLRGSLQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLT
880 890 900 910 920 930
1440 1450 1460 1470 1480 1490
pF1KA0 EVYGRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVYGRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEI
940 950 960 970 980 990
1500 1510 1520 1530 1540 1550
pF1KA0 LAYCISDTAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAYCISDTAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNM
1000 1010 1020 1030 1040 1050
1560 1570 1580 1590 1600 1610
pF1KA0 ILEAQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILEAQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEV
1060 1070 1080 1090 1100 1110
1620 1630 1640 1650 1660 1670
pF1KA0 TEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSH
1120 1130 1140 1150 1160 1170
1680 1690 1700 1710 1720 1730
pF1KA0 LSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPY
1180 1190 1200 1210 1220 1230
1740 1750 1760 1770 1780
pF1KA0 PQREKRS------DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERS
::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQREKRSAFSLSTDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERS
1240 1250 1260 1270 1280 1290
1790 1800 1810 1820 1830 1840
pF1KA0 FPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCS
1300 1310 1320 1330 1340 1350
1850 1860 1870 1880 1890 1900
pF1KA0 TKKMVVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADE
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
XP_016 TKKMVVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADE
1360 1370 1380 1390 1400 1410
1910 1920 1930 1940 1950 1960
pF1KA0 VEWILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEWILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTN
1420 1430 1440 1450 1460 1470
1970 1980 1990 2000 2010 2020
pF1KA0 PEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLD
1480 1490 1500 1510 1520 1530
2030 2040 2050 2060 2070 2080
pF1KA0 QILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFS
1540 1550 1560 1570 1580 1590
2090 2100 2110 2120 2130 2140
pF1KA0 RCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLA
1600 1610 1620 1630 1640 1650
2150 2160 2170 2180 2190 2200
pF1KA0 VIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGI
1660 1670 1680 1690 1700 1710
2210 2220 2230 2240 2250 2260
pF1KA0 FQPSYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQPSYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRA
1720 1730 1740 1750 1760 1770
2270 2280 2290 2300 2310 2320
pF1KA0 AMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADV
1780 1790 1800 1810 1820 1830
2330 2340 2350 2360 2370 2380
pF1KA0 SRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDG
1840 1850 1860 1870 1880 1890
2390 2400 2410 2420 2430 2440
pF1KA0 FGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNC
1900 1910 1920 1930 1940 1950
2450 2460 2470 2480 2490 2500
pF1KA0 LEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQA
1960 1970 1980 1990 2000 2010
2510 2520 2530
pF1KA0 AKSSGDAVVQDICAQWLLTSHPRGAHGPGSRK
::::::::::::::::::::::::::::::::
XP_016 AKSSGDAVVQDICAQWLLTSHPRGAHGPGSRK
2020 2030 2040
>>XP_016876616 (OMIM: 270700,612012) PREDICTED: zinc fin (1770 aa)
initn: 6344 init1: 6344 opt: 11685 Z-score: 9613.7 bits: 1792.5 E(85289): 0
Smith-Waterman score: 11685; 99.5% identity (99.7% similar) in 1768 aa overlap (778-2539:3-1770)
750 760 770 780 790 800
pF1KA0 RSEEQPSRRYQPATRHPSLRRGRRTRRSQADGRDRGSNPSLESTSSELSTSTSEGSLSAM
::::::::::::::::::::::::::::::
XP_016 MKDGRDRGSNPSLESTSSELSTSTSEGSLSAM
10 20 30
810 820 830 840 850 860
pF1KA0 SGRNELHSRLHPHPQSSLIPMMFSPPESLLASCILRGNFAEAHQVLFTFNLKSSPSSGEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGRNELHSRLHPHPQSSLIPMMFSPPESLLASCILRGNFAEAHQVLFTFNLKSSPSSGEL
40 50 60 70 80 90
870 880 890 900 910 920
pF1KA0 MFMERYQEVIQELAQVEHKIENQNSDAGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MFMERYQEVIQELAQVEHKIENQNSDAGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISD
100 110 120 130 140 150
930 940 950 960 970 980
pF1KA0 VTDKLLNTSGDPIPMLQEDFWISTALVEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTDKLLNTSGDPIPMLQEDFWISTALVEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKT
160 170 180 190 200 210
990 1000 1010 1020 1030 1040
pF1KA0 CKQLLETAERRLNSSLERRGRRIDHVLLNADGIRGFPVVLQQISKSLNYLLMTASQTKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
XP_016 CKQLLETAERRLNSSLERRGRRIDHVLLNADGIRGFPVVLQQISKSLNYLLMSASQTKSE
220 230 240 250 260 270
1050 1060 1070 1080 1090 1100
pF1KA0 SVEEKGGGPPRCSITELLQMCWPSLSEDCVASHTTLSQQLDQVLQSLREALELPEPRTPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVEEKGGGPPRCSITELLQMCWPSLSEDCVASHTTLSQQLDQVLQSLREALELPEPRTPP
280 290 300 310 320 330
1110 1120 1130 1140 1150 1160
pF1KA0 LSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGKQTPSGSRQMDYLGTFFSYCSTLAAVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGKQTPSGSRQMDYLGTFFSYCSTLAAVLL
340 350 360 370 380 390
1170 1180 1190 1200 1210 1220
pF1KA0 QSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLLFERQVPPERLAALLAQENLSLSVPQVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLLFERQVPPERLAALLAQENLSLSVPQVI
400 410 420 430 440 450
1230 1240 1250 1260 1270 1280
pF1KA0 VSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLHASHCLDDLPLSTPSSPRTTENPTLERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLHASHCLDDLPLSTPSSPRTTENPTLERK
460 470 480 490 500 510
1290 1300 1310 1320 1330 1340
pF1KA0 PYSSPRDSSLPALTSSALAFLKSRSKLLATVACLGASPRLKVSKPSLSWKELRGRREVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYSSPRDSSLPALTSSALAFLKSRSKLLATVACLGASPRLKVSKPSLSWKELRGRREVPL
520 530 540 550 560 570
1350 1360 1370 1380 1390 1400
pF1KA0 AAEQVARECERLLEQFPLFEAFLLAAWEPLRGSLQQGQSLAVNLCGWASLSTVLLGLHSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAEQVARECERLLEQFPLFEAFLLAAWEPLRGSLQQGQSLAVNLCGWASLSTVLLGLHSP
580 590 600 610 620 630
1410 1420 1430 1440 1450 1460
pF1KA0 IALDVLSEAFEESLVARDWSRALQLTEVYGRDVDDLSSIKDAVLSCAVACDKEGWQYLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IALDVLSEAFEESLVARDWSRALQLTEVYGRDVDDLSSIKDAVLSCAVACDKEGWQYLFP
640 650 660 670 680 690
1470 1480 1490 1500 1510 1520
pF1KA0 VKDASLRSRLALQFVDRWPLESCLEILAYCISDTAVQEGLKCELQRKLAELQVYQKILGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKDASLRSRLALQFVDRWPLESCLEILAYCISDTAVQEGLKCELQRKLAELQVYQKILGL
700 710 720 730 740 750
1530 1540 1550 1560 1570 1580
pF1KA0 QSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEYELCEEWGCLYPIPREHLISLHQKHLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEYELCEEWGCLYPIPREHLISLHQKHLLH
760 770 780 790 800 810
1590 1600 1610 1620 1630 1640
pF1KA0 LLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRH
820 830 840 850 860 870
1650 1660 1670 1680 1690 1700
pF1KA0 REIQALYVGSKILLTLPEQHRASYSHLSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REIQALYVGSKILLTLPEQHRASYSHLSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVG
880 890 900 910 920 930
1710 1720 1730 1740 1750 1760
pF1KA0 QEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS------DSVIHLQEIVHQAADPETLPR
::::::::::::::::::::::::::::::::: :::::::::::::::::::::
XP_016 QEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSAFSLSTDSVIHLQEIVHQAADPETLPR
940 950 960 970 980 990
1770 1780 1790 1800 1810 1820
pF1KA0 SPSAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVC
1000 1010 1020 1030 1040 1050
1830 1840 1850 1860 1870 1880
pF1KA0 CREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEPSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEPSE
1060 1070 1080 1090 1100 1110
1890 1900 1910 1920 1930 1940
pF1KA0 KPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIAIL
:::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPEALDSSKNESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIAIL
1120 1130 1140 1150 1160 1170
1950 1960 1970 1980 1990 2000
pF1KA0 NLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLAL
1180 1190 1200 1210 1220 1230
2010 2020 2030 2040 2050 2060
pF1KA0 CDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLD
1240 1250 1260 1270 1280 1290
2070 2080 2090 2100 2110 2120
pF1KA0 TTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFV
1300 1310 1320 1330 1340 1350
2130 2140 2150 2160 2170 2180
pF1KA0 SLQDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLQDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYV
1360 1370 1380 1390 1400 1410
2190 2200 2210 2220 2230 2240
pF1KA0 RHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTLENLLESIDPTLESWGKYLIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTLENLLESIDPTLESWGKYLIAA
1420 1430 1440 1450 1460 1470
2250 2260 2270 2280 2290 2300
pF1KA0 CQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKI
1480 1490 1500 1510 1520 1530
2310 2320 2330 2340 2350 2360
pF1KA0 YLQETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLQETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLP
1540 1550 1560 1570 1580 1590
2370 2380 2390 2400 2410 2420
pF1KA0 TLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSE
1600 1610 1620 1630 1640 1650
2430 2440 2450 2460 2470 2480
pF1KA0 IQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCK
1660 1670 1680 1690 1700 1710
2490 2500 2510 2520 2530
pF1KA0 LRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDICAQWLLTSHPRGAHGPGSRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDICAQWLLTSHPRGAHGPGSRK
1720 1730 1740 1750 1760 1770
>>XP_016876617 (OMIM: 270700,612012) PREDICTED: zinc fin (1739 aa)
initn: 6170 init1: 6170 opt: 11511 Z-score: 9470.6 bits: 1766.0 E(85289): 0
Smith-Waterman score: 11511; 99.5% identity (99.7% similar) in 1739 aa overlap (807-2539:1-1739)
780 790 800 810 820 830
pF1KA0 ADGRDRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESL
::::::::::::::::::::::::::::::
XP_016 MSGRNELHSRLHPHPQSSLIPMMFSPPESL
10 20 30
840 850 860 870 880 890
pF1KA0 LASCILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASCILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGS
40 50 60 70 80 90
900 910 920 930 940 950
pF1KA0 STIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEP
100 110 120 130 140 150
960 970 980 990 1000 1010
pF1KA0 TAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLN
160 170 180 190 200 210
1020 1030 1040 1050 1060 1070
pF1KA0 ADGIRGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDC
:::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
XP_016 ADGIRGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDC
220 230 240 250 260 270
1080 1090 1100 1110 1120 1130
pF1KA0 VASHTTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VASHTTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQK
280 290 300 310 320 330
1140 1150 1160 1170 1180 1190
pF1KA0 NLGKQTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLGKQTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLV
340 350 360 370 380 390
1200 1210 1220 1230 1240 1250
pF1KA0 SHLLFERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHLLFERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTL
400 410 420 430 440 450
1260 1270 1280 1290 1300 1310
pF1KA0 AQLHASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQLHASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLA
460 470 480 490 500 510
1320 1330 1340 1350 1360 1370
pF1KA0 TVACLGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVACLGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEP
520 530 540 550 560 570
1380 1390 1400 1410 1420 1430
pF1KA0 LRGSLQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRGSLQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVY
580 590 600 610 620 630
1440 1450 1460 1470 1480 1490
pF1KA0 GRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAY
640 650 660 670 680 690
1500 1510 1520 1530 1540 1550
pF1KA0 CISDTAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CISDTAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILE
700 710 720 730 740 750
1560 1570 1580 1590 1600 1610
pF1KA0 AQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQ
760 770 780 790 800 810
1620 1630 1640 1650 1660 1670
pF1KA0 SLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSS
820 830 840 850 860 870
1680 1690 1700 1710 1720 1730
pF1KA0 NPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQR
880 890 900 910 920 930
1740 1750 1760 1770 1780 1790
pF1KA0 EKRS------DSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPP
:::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKRSAFSLSTDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPP
940 950 960 970 980 990
1800 1810 1820 1830 1840 1850
pF1KA0 TQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKK
1000 1010 1020 1030 1040 1050
1860 1870 1880 1890 1900 1910
pF1KA0 MVVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADEVEW
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
XP_016 MVVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADEVEW
1060 1070 1080 1090 1100 1110
1920 1930 1940 1950 1960 1970
pF1KA0 ILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEV
1120 1130 1140 1150 1160 1170
1980 1990 2000 2010 2020 2030
pF1KA0 DAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQIL
1180 1190 1200 1210 1220 1230
2040 2050 2060 2070 2080 2090
pF1KA0 QPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCL
1240 1250 1260 1270 1280 1290
2100 2110 2120 2130 2140 2150
pF1KA0 KPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIP
1300 1310 1320 1330 1340 1350
2160 2170 2180 2190 2200 2210
pF1KA0 EGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQP
1360 1370 1380 1390 1400 1410
2220 2230 2240 2250 2260 2270
pF1KA0 SYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMT
1420 1430 1440 1450 1460 1470
2280 2290 2300 2310 2320 2330
pF1KA0 CIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRH
1480 1490 1500 1510 1520 1530
2340 2350 2360 2370 2380 2390
pF1KA0 MNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGI
1540 1550 1560 1570 1580 1590
2400 2410 2420 2430 2440 2450
pF1KA0 AFRVLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFRVLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEA
1600 1610 1620 1630 1640 1650
2460 2470 2480 2490 2500 2510
pF1KA0 FKRIPPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKRIPPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKS
1660 1670 1680 1690 1700 1710
2520 2530
pF1KA0 SGDAVVQDICAQWLLTSHPRGAHGPGSRK
:::::::::::::::::::::::::::::
XP_016 SGDAVVQDICAQWLLTSHPRGAHGPGSRK
1720 1730
>>XP_011534911 (OMIM: 270700,612012) PREDICTED: zinc fin (1666 aa)
initn: 11130 init1: 11130 opt: 11130 Z-score: 9157.4 bits: 1708.0 E(85289): 0
Smith-Waterman score: 11130; 99.9% identity (99.9% similar) in 1659 aa overlap (1-1659:1-1659)
10 20 30 40 50 60
pF1KA0 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPAN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 DSLSSPGAANLFSTYPARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 RGFPVVLQQISKSLNYLLMTASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_011 RGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASH
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLH
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVAC
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGS
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDV
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISD
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEY
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQ
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA0 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLF
:::::::::::::::::::::::::::::::::::::::
XP_011 HTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKIYPTNRFC
1630 1640 1650 1660
1690 1700 1710 1720 1730 1740
pF1KA0 MLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRS
>>XP_011525611 (OMIM: 615200) PREDICTED: pleckstrin homo (279 aa)
initn: 245 init1: 245 opt: 283 Z-score: 243.7 bits: 56.1 E(85289): 7.8e-07
Smith-Waterman score: 283; 28.8% identity (59.6% similar) in 156 aa overlap (1735-1885:71-225)
1710 1720 1730 1740 1750 1760
pF1KA0 LVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSDSVIHLQEIVHQAADPETLPRSPS
.:. ::. .: :.:.. . :::: .
XP_011 VLTKECRKKAKPRIFFLFNDILVYGSIVLNKRKYRSQHIIPLEEVTLELL-PETLQAKNR
50 60 70 80 90
1770 1780 1790 1800 1810
pF1KA0 AEFSPAAPPGISSIHSPSLRERSFPPTQPS--QEFVPPATPPARHQ---WVPDETESICM
.. : . : : . :.. . . ... . ::. .. :.::.. .:::
XP_011 WMIKTAKKSFVVSAASATERQEWISHIEECVRRQLRATGRPPSTEHAAPWIPDKATDICM
100 110 120 130 140 150
1820 1830 1840 1850 1860 1870
pF1KA0 VCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEP
: . .:. ..::::::.:: .::. :: ..... .:.:::. :: . .:
XP_011 RCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPRLSPKPVRVCSLCYRELAAQQRQEE
160 170 180 190 200 210
1880 1890 1900 1910 1920 1930
pF1KA0 SEKPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIA
.:. :
XP_011 AEEQGAGSPGQPAHLARPICGASSGDDDDSDEDKEGSRDGDWPSSVEFYASGVAWSAFHS
220 230 240 250 260 270
>>NP_077286 (OMIM: 615200) pleckstrin homology domain-co (279 aa)
initn: 245 init1: 245 opt: 283 Z-score: 243.7 bits: 56.1 E(85289): 7.8e-07
Smith-Waterman score: 283; 28.8% identity (59.6% similar) in 156 aa overlap (1735-1885:71-225)
1710 1720 1730 1740 1750 1760
pF1KA0 LVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSDSVIHLQEIVHQAADPETLPRSPS
.:. ::. .: :.:.. . :::: .
NP_077 VLTKECRKKAKPRIFFLFNDILVYGSIVLNKRKYRSQHIIPLEEVTLELL-PETLQAKNR
50 60 70 80 90
1770 1780 1790 1800 1810
pF1KA0 AEFSPAAPPGISSIHSPSLRERSFPPTQPS--QEFVPPATPPARHQ---WVPDETESICM
.. : . : : . :.. . . ... . ::. .. :.::.. .:::
NP_077 WMIKTAKKSFVVSAASATERQEWISHIEECVRRQLRATGRPPSTEHAAPWIPDKATDICM
100 110 120 130 140 150
1820 1830 1840 1850 1860 1870
pF1KA0 VCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEP
: . .:. ..::::::.:: .::. :: ..... .:.:::. :: . .:
NP_077 RCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPRLSPKPVRVCSLCYRELAAQQRQEE
160 170 180 190 200 210
1880 1890 1900 1910 1920 1930
pF1KA0 SEKPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIA
.:. :
NP_077 AEEQGAGSPGQPAHLARPICGASSGDDDDSDEDKEGSRDGDWPSSVEFYASGVAWSAFHS
220 230 240 250 260 270
>>XP_005259313 (OMIM: 615200) PREDICTED: pleckstrin homo (364 aa)
initn: 278 init1: 245 opt: 283 Z-score: 242.0 bits: 56.2 E(85289): 9.7e-07
Smith-Waterman score: 283; 28.8% identity (59.6% similar) in 156 aa overlap (1735-1885:156-310)
1710 1720 1730 1740 1750 1760
pF1KA0 LVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSDSVIHLQEIVHQAADPETLPRSPS
.:. ::. .: :.:.. . :::: .
XP_005 VLTKECRKKAKPRIFFLFNDILVYGSIVLNKRKYRSQHIIPLEEVTLELL-PETLQAKNR
130 140 150 160 170 180
1770 1780 1790 1800 1810
pF1KA0 AEFSPAAPPGISSIHSPSLRERSFPPTQPS--QEFVPPATPPARHQ---WVPDETESICM
.. : . : : . :.. . . ... . ::. .. :.::.. .:::
XP_005 WMIKTAKKSFVVSAASATERQEWISHIEECVRRQLRATGRPPSTEHAAPWIPDKATDICM
190 200 210 220 230 240
1820 1830 1840 1850 1860 1870
pF1KA0 VCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEP
: . .:. ..::::::.:: .::. :: ..... .:.:::. :: . .:
XP_005 RCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPRLSPKPVRVCSLCYRELAAQQRQEE
250 260 270 280 290 300
1880 1890 1900 1910 1920 1930
pF1KA0 SEKPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIA
.:. :
XP_005 AEEQGAGSPGQPAHLARPICGASSGDDDDSDEDKEGSRDGDWPSSVEFYASGVAWSAFHS
310 320 330 340 350 360
2539 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 18:34:26 2016 done: Wed Nov 2 18:34:30 2016
Total Scan time: 24.400 Total Display time: 1.560
Function used was FASTA [36.3.4 Apr, 2011]