Jatropha Genome Database
- JcCA0240561.10
BLASTP 2.2.24 [Aug-08-2010]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Altschul, Stephen F.,
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= JcCA0240561.10 - phase: 1 /partial
(416 letters)
Database: trembl
11,636,205 sequences; 3,746,823,912 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
B9H0T4_POPTR (tr|B9H0T4) Dihydrofolate reductase-thymidylate syn... 679 0.0
B9RH79_RICCO (tr|B9RH79) Bifunctional dihydrofolate reductase-th... 676 0.0
D7U4L1_VITVI (tr|D7U4L1) Whole genome shotgun sequence of line P... 642 0.0
Q39687_DAUCA (tr|Q39687) Dihydrofolate reductase-thymidylate syn... 611 e-173
D7L1V0_ARALY (tr|D7L1V0) Dihydrofolate reductase-thymidylate syn... 586 e-165
B0BLI5_LOTJA (tr|B0BLI5) CM0216.390.nc protein OS=Lotus japonicu... 585 e-165
C5Y2E9_SORBI (tr|C5Y2E9) Putative uncharacterized protein Sb05g0... 578 e-163
Q8L6F0_PEA (tr|Q8L6F0) Dihydrofolate reductase-thymidylate synth... 577 e-162
B9GAQ2_ORYSJ (tr|B9GAQ2) Putative uncharacterized protein OS=Ory... 574 e-162
Q2R481_ORYSJ (tr|Q2R481) Bifunctional dihydrofolate reductase-th... 573 e-161
B9GCZ3_ORYSJ (tr|B9GCZ3) Putative uncharacterized protein OS=Ory... 573 e-161
B9R7Y4_RICCO (tr|B9R7Y4) Bifunctional dihydrofolate reductase-th... 570 e-161
B6UD82_MAIZE (tr|B6UD82) Bifunctional dihydrofolate reductase-th... 566 e-159
D7MEC7_ARALY (tr|D7MEC7) Predicted protein OS=Arabidopsis lyrata... 563 e-158
B8BPG2_ORYSI (tr|B8BPG2) Putative uncharacterized protein OS=Ory... 546 e-153
B7FA29_ORYSJ (tr|B7FA29) cDNA, clone: J100037K11, full insert se... 546 e-153
B8BKI9_ORYSI (tr|B8BKI9) Putative uncharacterized protein OS=Ory... 532 e-149
B9HRK6_POPTR (tr|B9HRK6) Dihydrofolate reductase-thymidylate syn... 469 e-130
A9RXS0_PHYPA (tr|A9RXS0) Predicted protein OS=Physcomitrella pat... 423 e-116
Q9SIK4_ARATH (tr|Q9SIK4) Putative dihydrofolate reductase-thymid... 408 e-112
D7LBE8_ARALY (tr|D7LBE8) Predicted protein OS=Arabidopsis lyrata... 398 e-109
A4RXM1_OSTLU (tr|A4RXM1) Predicted protein OS=Ostreococcus lucim... 384 e-105
Q01FK1_OSTTA (tr|Q01FK1) Bifunctional dihydrofolate reductase-th... 384 e-104
C1MMA6_MICPS (tr|C1MMA6) Bifunctional dihydrofolate reductase-th... 377 e-102
C1E6F7_9CHLO (tr|C1E6F7) Bifunctional dihydrofolate reductase-th... 370 e-100
A8JD96_CHLRE (tr|A8JD96) Predicted protein OS=Chlamydomonas rein... 363 2e-98
D0N806_PHYIN (tr|D0N806) Bifunctional dihydrofolate reductase-th... 321 9e-86
B9H4E7_POPTR (tr|B9H4E7) Dihydrofolate reductase-thymidylate syn... 312 5e-83
Q22KR8_TETTH (tr|Q22KR8) Bifunctional dihydrofolate reductase-th... 308 7e-82
B5YMV7_THAPS (tr|B5YMV7) Possible thymidylate synthase (Fragment... 293 3e-77
C5LQI2_9ALVE (tr|C5LQI2) Dihydrofolate reductase-thymidylate syn... 285 5e-75
B9H4E4_POPTR (tr|B9H4E4) Dihydrofolate reductase-thymidylate syn... 284 1e-74
C5KZ80_9ALVE (tr|C5KZ80) Dihydrofolate reductase/thymidilate syn... 284 1e-74
B7FQJ9_PHATR (tr|B7FQJ9) Predicted protein (Fragment) OS=Phaeoda... 275 9e-72
Q8MXB7_LEITR (tr|Q8MXB7) Dihydrofolate reductase-thymidylate syn... 272 5e-71
Q8MXB8_LEITR (tr|Q8MXB8) Dihydrofolate reductase-thymidylate syn... 271 1e-70
A4H4P8_LEIBR (tr|A4H4P8) Dihydrofolate reductase-thymidylate syn... 271 1e-70
Q8MQV3_LEIIN (tr|Q8MQV3) Dihydrofolate reductase/thymidylate syn... 267 2e-69
Q8MQV1_LEICH (tr|Q8MQV1) Dhfr-ts OS=Leishmania chagasi PE=4 SV=1 266 4e-69
B5U9U8_BABGI (tr|B5U9U8) Dihydrofolate reductase-thymidylate syn... 265 1e-68
Q8T5T9_TRYCR (tr|Q8T5T9) Dihydrofolate reductase-thymidylate syn... 261 8e-68
D3JLB2_TRYCR (tr|D3JLB2) Dihydrofolate reductase-thymidylate syn... 261 9e-68
D3JL96_TRYCR (tr|D3JL96) Dihydrofolate reductase-thymidylate syn... 261 9e-68
Q95NI3_TRYCR (tr|Q95NI3) Dihydrofolate reductase-thymidylate syn... 261 9e-68
D3JL87_TRYCR (tr|D3JL87) Dihydrofolate reductase-thymidylate syn... 261 9e-68
C9ZTK8_TRYBG (tr|C9ZTK8) Dihydrofolate reductase-thymidylate syn... 261 1e-67
D3JL83_TRYCR (tr|D3JL83) Dihydrofolate reductase-thymidylate syn... 261 1e-67
D3JLB1_TRYCR (tr|D3JLB1) Dihydrofolate reductase-thymidylate syn... 261 1e-67
Q8T5T8_TRYCR (tr|Q8T5T8) Dihydrofolate reductase-thymidylate syn... 261 1e-67
Q582G3_9TRYP (tr|Q582G3) Dihydrofolate reductase-thymidylate syn... 261 1e-67
D3JLA1_TRYCR (tr|D3JLA1) Dihydrofolate reductase-thymidylate syn... 261 1e-67
Q95NS0_TRYCR (tr|Q95NS0) Dihydrofolate reductase-thymidylate syn... 261 1e-67
D3JL86_TRYCR (tr|D3JL86) Dihydrofolate reductase-thymidylate syn... 261 1e-67
D3JL82_TRYCR (tr|D3JL82) Dihydrofolate reductase-thymidylate syn... 261 1e-67
Q963S7_9TRYP (tr|Q963S7) Dihydrofolate reductase-thymidylate syn... 261 1e-67
Q95NT2_TRYCR (tr|Q95NT2) Dihydrofolate reductase-thymidylate syn... 261 1e-67
Q4DLS1_TRYCR (tr|Q4DLS1) Dihydrofolate reductase-thymidylate syn... 260 2e-67
Q95NX3_TRYCR (tr|Q95NX3) Dihydrofolate reductase-thymidylate syn... 260 2e-67
Q95NY4_TRYCR (tr|Q95NY4) Dihydrofolate reductase-thymidylate syn... 260 3e-67
D3JLA6_TRYCR (tr|D3JLA6) Dihydrofolate reductase-thymidylate syn... 259 5e-67
Q963S8_TRYCR (tr|Q963S8) Dihydrofolate reductase-thymidylate syn... 257 2e-66
Q4QIZ1_LEIMA (tr|Q4QIZ1) Dihydrofolate reductase-thymidylate syn... 256 3e-66
B9QD29_TOXGO (tr|B9QD29) Bifunctional dihydrofolate reductase-th... 256 4e-66
B9PR34_TOXGO (tr|B9PR34) Bifunctional dihydrofolate reductase-th... 256 4e-66
B6KHC9_TOXGO (tr|B6KHC9) Bifunctional dihydrofolate reductase / ... 256 4e-66
C6T8H1_SOYBN (tr|C6T8H1) Putative uncharacterized protein OS=Gly... 255 6e-66
D3JLA7_TRYCR (tr|D3JLA7) Dihydrofolate reductase-thymidylate syn... 254 1e-65
A7ASX7_BABBO (tr|A7ASX7) Dihydrofolate reductase/thymidylate syn... 253 2e-65
Q5CGA3_CRYHO (tr|Q5CGA3) Chain A, crystal structure of Dhfr OS=C... 253 4e-65
Q27552_CRYPV (tr|Q27552) Bifunctional dihydrofolate reductase-th... 253 4e-65
Q27551_CRYPV (tr|Q27551) Bifunctional dihydrofolate reductase-th... 252 6e-65
Q5CPQ4_CRYPV (tr|Q5CPQ4) Dihydrofolate reductase-thymidylate syn... 252 7e-65
Q7Z0Z9_BABBO (tr|Q7Z0Z9) Dihydrofolate reductase/thymidilate syn... 250 3e-64
Q4A320_EHV86 (tr|Q4A320) Bifunctional dihydrofolate reductase-th... 244 1e-62
D2TF54_9VIRU (tr|D2TF54) Bifunctional dihydrofolate reductase-th... 243 2e-62
Q95US9_PLAGA (tr|Q95US9) Dihydrofolate reductase/thymidylate syn... 243 3e-62
Q7RGH7_PLAYO (tr|Q7RGH7) Thymidylate synthase, putative OS=Plasm... 240 2e-61
Q4XXZ2_PLACH (tr|Q4XXZ2) Bifunctional dihydrofolate reductase-th... 240 3e-61
B6AE97_CRYMR (tr|B6AE97) Thymidylate synthase family protein OS=... 237 2e-60
Q4U9G5_THEAN (tr|Q4U9G5) Bifunctional dihydrofolate reductase/th... 236 4e-60
Q4YWH2_PLABE (tr|Q4YWH2) Bifunctional dihydrofolate reductase-th... 233 3e-59
Q4N262_THEPA (tr|Q4N262) Dihydrofolate reductase-thymidylate syn... 229 4e-58
D3VZW1_9APIC (tr|D3VZW1) Dihydrofolate reductase-thymidylate syn... 228 1e-57
D3VZW0_9APIC (tr|D3VZW0) Dihydrofolate reductase-thymidylate syn... 226 3e-57
D3VZW2_9APIC (tr|D3VZW2) Dihydrofolate reductase-thymidylate syn... 226 4e-57
D2W4C0_NAEGR (tr|D2W4C0) Predicted protein OS=Naegleria gruberi ... 225 6e-57
D3VZV9_PLARE (tr|D3VZV9) Dihydrofolate reductase-thymidylate syn... 224 2e-56
Q06BX0_9CILI (tr|Q06BX0) Dihydrofolate reductase-thymidylate syn... 223 5e-56
Q8MVZ6_9EUGL (tr|Q8MVZ6) Bifunctional dihydrofolate reductase-th... 222 6e-56
Q06BX2_9CILI (tr|Q06BX2) Dihydrofolate reductase-thymidylate syn... 221 1e-55
Q8MVZ8_9EUKA (tr|Q8MVZ8) Bifunctional dihydrofolate reductase-th... 220 3e-55
Q8LL90_9STRA (tr|Q8LL90) Bifunctional dihydrofolate reductase-th... 218 9e-55
Q06BX1_9CILI (tr|Q06BX1) Dihydrofolate reductase-thymidylate syn... 215 9e-54
C6GJB8_LITVA (tr|C6GJB8) Thymidylate synthase OS=Litopenaeus van... 212 5e-53
B3RLB4_TRIAD (tr|B3RLB4) Thymidylate synthase OS=Trichoplax adha... 207 2e-51
A7RH38_NEMVE (tr|A7RH38) Thymidylate synthase OS=Nematostella ve... 207 2e-51
Q6WEA9_9EUKA (tr|Q6WEA9) Thymidylate synthase (Fragment) OS=Cora... 206 3e-51
Q8MVZ5_9HYMN (tr|Q8MVZ5) Bifunctional dihydrofolate reductase-th... 204 2e-50
Q8MW00_9EUKA (tr|Q8MW00) Bifunctional dihydrofolate reductase-th... 203 3e-50
D2A1S6_TRICA (tr|D2A1S6) Thymidylate synthase OS=Tribolium casta... 200 2e-49
C3ZXJ5_BRAFL (tr|C3ZXJ5) Thymidylate synthase OS=Branchiostoma f... 200 3e-49
Q544L2_MOUSE (tr|Q544L2) Thymidylate synthase OS=Mus musculus GN... 199 4e-49
Q9D0H1_MOUSE (tr|Q9D0H1) Thymidylate synthase OS=Mus musculus GN... 199 4e-49
A8K9A5_HUMAN (tr|A8K9A5) Thymidylate synthase OS=Homo sapiens PE... 198 8e-49
Q53Y97_HUMAN (tr|Q53Y97) Thymidylate synthase OS=Homo sapiens GN... 198 9e-49
Q53FB7_HUMAN (tr|Q53FB7) Thymidylate synthase (Fragment) OS=Homo... 198 9e-49
Q7QDW7_ANOGA (tr|Q7QDW7) Thymidylate synthase OS=Anopheles gambi... 198 9e-49
A4HSX8_LEIIN (tr|A4HSX8) Thymidylate synthase OS=Leishmania infa... 198 1e-48
Q8VDV6_MOUSE (tr|Q8VDV6) Thymidylate synthase OS=Mus musculus GN... 198 1e-48
C0H809_SALSA (tr|C0H809) Thymidylate synthase OS=Salmo salar GN=... 195 8e-48
B0WW05_CULQU (tr|B0WW05) Thymidylate synthase OS=Culex quinquefa... 195 8e-48
B6K7B9_SCHJY (tr|B6K7B9) Thymidylate synthase OS=Schizosaccharom... 194 1e-47
Q9DGH5_DANRE (tr|Q9DGH5) Thymidylate synthase OS=Danio rerio GN=... 194 1e-47
Q6P045_DANRE (tr|Q6P045) Thymidylate synthase OS=Danio rerio GN=... 194 1e-47
Q7ZUI7_DANRE (tr|Q7ZUI7) Thymidylate synthase OS=Danio rerio GN=... 194 1e-47
D3JLA5_TRYCR (tr|D3JLA5) Thymidylate synthase (Fragment) OS=Tryp... 194 2e-47
Q80BK9_SHV2 (tr|Q80BK9) Thymidylate synthase OS=Saimiriine herpe... 193 4e-47
Q6WEA3_9EUKA (tr|Q6WEA3) Thymidylate synthase (Fragment) OS=Hart... 192 5e-47
C4WVP2_ACYPI (tr|C4WVP2) Thymidylate synthase OS=Acyrthosiphon p... 192 7e-47
B5XCJ1_SALSA (tr|B5XCJ1) Thymidylate synthase OS=Salmo salar GN=... 192 8e-47
Q16JK1_AEDAE (tr|Q16JK1) Thymidylate synthase OS=Aedes aegypti G... 192 8e-47
Q9YTJ6_ATHV3 (tr|Q9YTJ6) Thymidylate synthase OS=Ateline herpesv... 191 1e-46
C1BZP1_ESOLU (tr|C1BZP1) Thymidylate synthase OS=Esox lucius GN=... 191 1e-46
Q0IHX3_XENTR (tr|Q0IHX3) Thymidylate synthase OS=Xenopus tropica... 191 2e-46
B3NAN1_DROER (tr|B3NAN1) Thymidylate synthase OS=Drosophila erec... 191 2e-46
A1L2V6_XENLA (tr|A1L2V6) Thymidylate synthase OS=Xenopus laevis ... 190 2e-46
Q6WEA7_9EUKA (tr|Q6WEA7) Thymidylate synthase (Fragment) OS=Hart... 190 2e-46
A8XXD3_CAEBR (tr|A8XXD3) Thymidylate synthase OS=Caenorhabditis ... 190 3e-46
B4KHK2_DROMO (tr|B4KHK2) Thymidylate synthase OS=Drosophila moja... 190 3e-46
Q2F5K5_BOMMO (tr|Q2F5K5) Thymidylate synthase OS=Bombyx mori PE=... 190 3e-46
Q6WEA1_9EUKA (tr|Q6WEA1) Thymidylate synthase (Fragment) OS=Hart... 189 4e-46
Q9NDD3_TRISP (tr|Q9NDD3) Thymidylate synthase OS=Trichinella spi... 189 4e-46
Q5DGT4_SCHJA (tr|Q5DGT4) Thymidylate synthase OS=Schistosoma jap... 189 7e-46
C4Q3X9_SCHMA (tr|C4Q3X9) Thymidylate synthase OS=Schistosoma man... 188 8e-46
Q9Y052_CAEEL (tr|Q9Y052) Thymidylate synthase OS=Caenorhabditis ... 188 1e-45
Q9N588_CAEEL (tr|Q9N588) Thymidylate synthase OS=Caenorhabditis ... 188 1e-45
D2HJY4_AILME (tr|D2HJY4) Thymidylate synthase (Fragment) OS=Ailu... 188 1e-45
Q9E202_9ALPH (tr|Q9E202) Thymidylate synthase OS=Cercopithecine ... 188 1e-45
B4NLJ1_DROWI (tr|B4NLJ1) Thymidylate synthase OS=Drosophila will... 188 1e-45
D2XB64_9VIRU (tr|D2XB64) Bifunctional dihydrofolate reductase-th... 187 1e-45
Q2HRC4_HHV8P (tr|Q2HRC4) Thymidylate synthase OS=Human herpesvir... 187 2e-45
D0UZM0_HHV8 (tr|D0UZM0) Thymidylate synthase OS=Human herpesviru... 187 2e-45
Q6WEA5_9EUKA (tr|Q6WEA5) Thymidylate synthase (Fragment) OS=Hart... 187 2e-45
Q91LI6_WSSV (tr|Q91LI6) Thymidylate synthase OS=White spot syndr... 187 2e-45
A4RMX7_MAGGR (tr|A4RMX7) Thymidylate synthase OS=Magnaporthe gri... 187 2e-45
B4M9C1_DROVI (tr|B4M9C1) Thymidylate synthase OS=Drosophila viri... 187 2e-45
B4GSA5_DROPE (tr|B4GSA5) Thymidylate synthase OS=Drosophila pers... 187 3e-45
A8C2U4_PLAMA (tr|A8C2U4) Dihydrofolate reductase-thymidylate syn... 186 4e-45
A3GG41_PICST (tr|A3GG41) Thymidylate synthase OS=Pichia stipitis... 186 4e-45
B4JCJ9_DROGR (tr|B4JCJ9) Thymidylate synthase OS=Drosophila grim... 186 5e-45
A8C2U6_PLAMA (tr|A8C2U6) Dihydrofolate reductase-thymidylate syn... 186 5e-45
A8C2U2_PLAMA (tr|A8C2U2) Dihydrofolate reductase-thymidylate syn... 186 5e-45
A8C2U7_PLABR (tr|A8C2U7) Dihydrofolate reductase-thymidylate syn... 186 5e-45
Q91CH7_9ALPH (tr|Q91CH7) Thymidylate synthase OS=Macropodid herp... 186 6e-45
Q0IJY2_PLAMA (tr|Q0IJY2) Dihydrofolate reductase-thymidylate syn... 186 6e-45
D7EIA1_TRICA (tr|D7EIA1) Putative uncharacterized protein OS=Tri... 185 7e-45
D5GJQ2_9PEZI (tr|D5GJQ2) Thymidylate synthase OS=Tuber melanospo... 185 9e-45
Q8QTF3_WSSV (tr|Q8QTF3) Thymidylate synthase OS=White spot syndr... 185 1e-44
A5HEW4_WSSV (tr|A5HEW4) Thymidylate synthase OS=White spot syndr... 184 1e-44
Q29KG5_DROPS (tr|Q29KG5) Thymidylate synthase OS=Drosophila pseu... 184 1e-44
D2CLW7_9APIC (tr|D2CLW7) Dihydrofolate reductase-thymidylate syn... 184 2e-44
D2CLW6_9APIC (tr|D2CLW6) Dihydrofolate reductase-thymidylate syn... 184 2e-44
D2CLW8_9APIC (tr|D2CLW8) Dihydrofolate reductase-thymidylate syn... 184 2e-44
D2CLW4_9APIC (tr|D2CLW4) Dihydrofolate reductase-thymidylate syn... 184 2e-44
B7QMU1_IXOSC (tr|B7QMU1) Thymidylate synthase OS=Ixodes scapular... 184 2e-44
B4NBS5_DROWI (tr|B4NBS5) Thymidylate synthase OS=Drosophila will... 184 2e-44
D2CLX6_9APIC (tr|D2CLX6) Dihydrofolate reductase-thymidylate syn... 184 2e-44
D2CLX8_9APIC (tr|D2CLX8) Dihydrofolate reductase-thymidylate syn... 184 2e-44
D2CLY1_9APIC (tr|D2CLY1) Dihydrofolate reductase-thymidylate syn... 184 2e-44
B4NXB1_DROYA (tr|B4NXB1) Thymidylate synthase OS=Drosophila yaku... 184 2e-44
Q4PBV6_USTMA (tr|Q4PBV6) Thymidylate synthase OS=Ustilago maydis... 183 3e-44
D2CLX1_9APIC (tr|D2CLX1) Dihydrofolate reductase-thymidylate syn... 183 3e-44
C4YIJ5_CANAL (tr|C4YIJ5) Thymidylate synthase OS=Candida albican... 183 4e-44
B7P7E2_IXOSC (tr|B7P7E2) Thymidylate synthase (Fragment) OS=Ixod... 182 4e-44
D2CLX0_9APIC (tr|D2CLX0) Dihydrofolate reductase-thymidylate syn... 182 5e-44
B7QLC8_IXOSC (tr|B7QLC8) Thymidylate synthase OS=Ixodes scapular... 182 5e-44
D2CLX2_9APIC (tr|D2CLX2) Dihydrofolate reductase-thymidylate syn... 182 6e-44
D2CLX4_9APIC (tr|D2CLX4) Dihydrofolate reductase-thymidylate syn... 182 6e-44
D2CLY0_9APIC (tr|D2CLY0) Dihydrofolate reductase-thymidylate syn... 182 6e-44
D2CLX9_9APIC (tr|D2CLX9) Dihydrofolate reductase-thymidylate syn... 182 6e-44
D2CLX3_9APIC (tr|D2CLX3) Dihydrofolate reductase-thymidylate syn... 182 6e-44
B9WBH8_CANDC (tr|B9WBH8) Thymidylate synthase OS=Candida dublini... 182 7e-44
D2CLW9_9APIC (tr|D2CLW9) Dihydrofolate reductase-thymidylate syn... 182 7e-44
B5RT83_DEBHA (tr|B5RT83) Thymidylate synthase OS=Debaryomyces ha... 182 8e-44
Q8WYK3_HUMAN (tr|Q8WYK3) Thymidylate synthase OS=Homo sapiens GN... 182 9e-44
C4R672_PICPG (tr|C4R672) Thymidylate synthase OS=Pichia pastoris... 182 9e-44
B4Q910_DROSI (tr|B4Q910) Thymidylate synthase OS=Drosophila simu... 181 1e-43
Q541C9_DROME (tr|Q541C9) Thymidylate synthase OS=Drosophila mela... 181 1e-43
Q9YVK4_MSEPV (tr|Q9YVK4) Thymidylate synthase OS=Melanoplus sang... 181 1e-43
B3MLB9_DROAN (tr|B3MLB9) Thymidylate synthase OS=Drosophila anan... 181 1e-43
D2CLX7_9APIC (tr|D2CLX7) Dihydrofolate reductase-thymidylate syn... 181 2e-43
D2CLX5_9APIC (tr|D2CLX5) Dihydrofolate reductase-thymidylate syn... 181 2e-43
A1Y2B9_LEITR (tr|A1Y2B9) Dihydrofolate reductase-thymidylate syn... 181 2e-43
Q8MVZ9_9EUKA (tr|Q8MVZ9) Bifunctional dihydrofolate reductase-th... 180 2e-43
C5M729_CANTT (tr|C5M729) Thymidylate synthase OS=Candida tropica... 180 3e-43
B7G430_PHATR (tr|B7G430) Thymidylate synthase (Fragment) OS=Phae... 180 4e-43
A5DTE4_LODEL (tr|A5DTE4) Thymidylate synthase OS=Lodderomyces el... 179 4e-43
A1Y2C0_LEITR (tr|A1Y2C0) Dihydrofolate reductase-thymidylate syn... 179 4e-43
C8VB77_EMENI (tr|C8VB77) Putative uncharacterized protein OS=Asp... 179 6e-43
B4I2T1_DROSE (tr|B4I2T1) Thymidylate synthase OS=Drosophila sech... 179 7e-43
C5DNV0_ZYGRC (tr|C5DNV0) Thymidylate synthase OS=Zygosaccharomyc... 179 8e-43
A1Y2C1_LEITR (tr|A1Y2C1) Dihydrofolate reductase-thymidylate syn... 178 8e-43
Q5AXF2_EMENI (tr|Q5AXF2) Putative uncharacterized protein OS=Eme... 178 9e-43
Q19N45_PLAVI (tr|Q19N45) Dihydrofolate reductase-thymidylate syn... 178 9e-43
Q19N44_PLAVI (tr|Q19N44) Dihydrofolate reductase-thymidylate syn... 178 1e-42
C8ZI35_YEAS8 (tr|C8ZI35) Thymidylate synthase OS=Saccharomyces c... 178 1e-42
D6W2D7_YEAST (tr|D6W2D7) Cdc21p OS=Saccharomyces cerevisiae S288... 177 1e-42
C7GT41_YEAS2 (tr|C7GT41) Thymidylate synthase OS=Saccharomyces c... 177 1e-42
B3LJC3_YEAS1 (tr|B3LJC3) Thymidylate synthase OS=Saccharomyces c... 177 1e-42
Q19N42_PLAVI (tr|Q19N42) Dihydrofolate reductase-thymidylate syn... 177 1e-42
Q19N40_PLAVI (tr|Q19N40) Dihydrofolate reductase-thymidylate syn... 177 1e-42
Q19N46_PLAVI (tr|Q19N46) Dihydrofolate reductase-thymidylate syn... 177 2e-42
C3RUB1_PLAVI (tr|C3RUB1) Dihydrofolate reductase-thymidylate syn... 177 2e-42
A5K620_PLAVI (tr|A5K620) Bifunctional dihydrofolate reductase-th... 177 2e-42
C4XY75_CLAL4 (tr|C4XY75) Thymidylate synthase OS=Clavispora lusi... 177 2e-42
C3RUA8_PLAVI (tr|C3RUA8) Dihydrofolate reductase-thymidylate syn... 177 2e-42
C3RUB2_PLAVI (tr|C3RUB2) Dihydrofolate reductase-thymidylate syn... 177 2e-42
Q19PB8_PLAVI (tr|Q19PB8) Dihydrofolate reductase-thymidylate syn... 177 2e-42
C3RUA7_PLAVI (tr|C3RUA7) Dihydrofolate reductase-thymidylate syn... 177 2e-42
C3RUA6_PLAVI (tr|C3RUA6) Dihydrofolate reductase-thymidylate syn... 177 2e-42
A7ET01_SCLS1 (tr|A7ET01) Thymidylate synthase OS=Sclerotinia scl... 177 2e-42
C9SFX8_VERA1 (tr|C9SFX8) Thymidylate synthase OS=Verticillium al... 177 2e-42
A6RSC0_BOTFB (tr|A6RSC0) Thymidylate synthase OS=Botryotinia fuc... 177 2e-42
Q19N43_PLAVI (tr|Q19N43) Dihydrofolate reductase-thymidylate syn... 177 3e-42
B3L1J6_PLAKH (tr|B3L1J6) Bifunctional dihydrofolate reductase-th... 176 4e-42
Q8JKK4_9VIRU (tr|Q8JKK4) Thymidylate synthase OS=Heliothis zea v... 176 5e-42
Q19PC0_PLAVI (tr|Q19PC0) Dihydrofolate reductase-thymidylate syn... 176 6e-42
Q53D48_9GAMA (tr|Q53D48) Thymidylate synthase OS=Macaca fuscata ... 175 7e-42
C0NVN1_AJECG (tr|C0NVN1) Thymidylate synthase OS=Ajellomyces cap... 175 7e-42
C3S7P8_PLAFA (tr|C3S7P8) Dihydrofolate reductase/thymidylate syn... 175 9e-42
Q8I1R6_PLAF7 (tr|Q8I1R6) Bifunctional dihydrofolate reductase-th... 175 9e-42
A7UD81_PLAFA (tr|A7UD81) Dihydrofolate reductase-thymidylate syn... 175 9e-42
A7UD79_PLAFA (tr|A7UD79) Dihydrofolate reductase-thymidylate syn... 175 9e-42
B5VRX1_YEAS6 (tr|B5VRX1) YOR074Cp-like protein (Fragment) OS=Sac... 175 9e-42
A6RED4_AJECN (tr|A6RED4) Thymidylate synthase OS=Ajellomyces cap... 175 1e-41
D3VZV8_PLARE (tr|D3VZV8) Dihydrofolate reductase-thymidylate syn... 175 1e-41
A8NHY0_COPC7 (tr|A8NHY0) Thymidylate synthase OS=Coprinopsis cin... 175 1e-41
Q2GPK8_CHAGB (tr|Q2GPK8) Thymidylate synthase OS=Chaetomium glob... 174 1e-41
Q19N41_PLAVI (tr|Q19N41) Dihydrofolate reductase-thymidylate syn... 174 1e-41
A8Q268_MALGO (tr|A8Q268) Thymidylate synthase OS=Malassezia glob... 174 2e-41
A2R2F6_ASPNC (tr|A2R2F6) Thymidylate synthase OS=Aspergillus nig... 174 2e-41
C5DJN5_LACTC (tr|C5DJN5) Thymidylate synthase OS=Lachancea therm... 174 2e-41
Q19PB9_PLAVI (tr|Q19PB9) Dihydrofolate reductase-thymidylate syn... 174 2e-41
Q6CXJ0_KLULA (tr|Q6CXJ0) Thymidylate synthase OS=Kluyveromyces l... 174 2e-41
A1D9J9_NEOFI (tr|A1D9J9) Thymidylate synthase OS=Neosartorya fis... 174 3e-41
B6H3G1_PENCW (tr|B6H3G1) Thymidylate synthase OS=Penicillium chr... 173 3e-41
B7XJG9_ENTBH (tr|B7XJG9) Thymidylate synthase OS=Enterocytozoon ... 173 4e-41
C4JH67_UNCRE (tr|C4JH67) Thymidylate synthase OS=Uncinocarpus re... 172 5e-41
Q9J2M3_9GAMA (tr|Q9J2M3) Thymidylate synthase OS=Rhesus monkey r... 172 5e-41
Q4W9N9_ASPFU (tr|Q4W9N9) Thymidylate synthase OS=Aspergillus fum... 172 5e-41
B0YED1_ASPFC (tr|B0YED1) Thymidylate synthase OS=Aspergillus fum... 172 5e-41
Q9WRT8_9GAMA (tr|Q9WRT8) Thymidylate synthase OS=Macaca mulatta ... 172 6e-41
Q77V82_9GAMA (tr|Q77V82) Thymidylate synthase OS=Macacine herpes... 172 6e-41
Q0Z9A6_CANGA (tr|Q0Z9A6) Thymidylate synthase OS=Candida glabrat... 172 6e-41
A7TDS8_VANPO (tr|A7TDS8) Thymidylate synthase OS=Vanderwaltozyma... 172 7e-41
Q2PIT9_ASPOR (tr|Q2PIT9) Thymidylate synthase OS=Aspergillus ory... 171 1e-40
B8NYX8_ASPFN (tr|B8NYX8) Thymidylate synthase OS=Aspergillus fla... 171 1e-40
B6QAM1_PENMQ (tr|B6QAM1) Thymidylate synthase OS=Penicillium mar... 171 1e-40
Q759Q4_ASHGO (tr|Q759Q4) Thymidylate synthase OS=Ashbya gossypii... 171 1e-40
Q678J8_9VIRU (tr|Q678J8) Thymidylate synthase OS=Lymphocystis di... 171 1e-40
B0DZY1_LACBS (tr|B0DZY1) Thymidylate synthase OS=Laccaria bicolo... 171 1e-40
D4DHD9_TRIVH (tr|D4DHD9) Thymidylate synthase OS=Trichophyton ve... 171 2e-40
D4B532_ARTBC (tr|D4B532) Thymidylate synthase OS=Arthroderma ben... 171 2e-40
Q6CCB3_YARLI (tr|Q6CCB3) Thymidylate synthase OS=Yarrowia lipoly... 171 2e-40
B8LZ81_TALSN (tr|B8LZ81) Thymidylate synthase OS=Talaromyces sti... 171 2e-40
B2WMW5_PYRTR (tr|B2WMW5) Thymidylate synthase OS=Pyrenophora tri... 169 4e-40
A1C942_ASPCL (tr|A1C942) Thymidylate synthase OS=Aspergillus cla... 169 5e-40
A8PSN6_BRUMA (tr|A8PSN6) Thymidylate synthase OS=Brugia malayi G... 169 5e-40
C5P3V9_COCP7 (tr|C5P3V9) Thymidylate synthase OS=Coccidioides po... 169 7e-40
C5FFM4_NANOT (tr|C5FFM4) Thymidylate synthase OS=Nannizzia otae ... 169 8e-40
Q6QCP2_HHV3 (tr|Q6QCP2) Thymidylate synthase OS=Human herpesviru... 168 1e-39
C5JX90_AJEDS (tr|C5JX90) Thymidylate synthase OS=Ajellomyces der... 168 1e-39
C5GRQ7_AJEDR (tr|C5GRQ7) Thymidylate synthase OS=Ajellomyces der... 168 1e-39
O39238_9GAMA (tr|O39238) Thymidylate synthase (Fragment) OS=Rhes... 168 1e-39
A5DPY2_PICGU (tr|A5DPY2) Thymidylate synthase OS=Pichia guillier... 167 2e-39
C1HCV6_PARBA (tr|C1HCV6) Thymidylate synthase OS=Paracoccidioide... 167 3e-39
C7YGS3_NECH7 (tr|C7YGS3) Thymidylate synthase OS=Nectria haemato... 166 4e-39
C0SJC8_PARBP (tr|C0SJC8) Thymidylate synthase OS=Paracoccidioide... 163 3e-38
C1GMP4_PARBD (tr|C1GMP4) Thymidylate synthase OS=Paracoccidioide... 161 1e-37
Q307G5_SHEEP (tr|Q307G5) Thymidylate synthase (Fragment) OS=Ovis... 160 3e-37
D1ZGM0_SORMA (tr|D1ZGM0) Thymidylate synthase OS=Sordaria macros... 157 3e-36
D2E8C6_9VIRU (tr|D2E8C6) ORF75 OS=Anguillid herpesvirus 1 PE=3 SV=1 155 1e-35
B2YFY9_9VIRU (tr|B2YFY9) Thymidylate synthase OS=Musca domestica... 154 1e-35
C1KES3_PANPA (tr|C1KES3) Thymidylate synthase (Fragment) OS=Pan ... 154 2e-35
C1KES2_PANTR (tr|C1KES2) Thymidylate synthase (Fragment) OS=Pan ... 154 2e-35
C1KES6_MACMU (tr|C1KES6) Thymidylate synthase (Fragment) OS=Maca... 154 2e-35
C1KES4_9PRIM (tr|C1KES4) Thymidylate synthase (Fragment) OS=Gori... 154 2e-35
Q7S072_NEUCR (tr|Q7S072) Thymidylate synthase OS=Neurospora cras... 153 3e-35
C1KES7_SAISC (tr|C1KES7) Thymidylate synthase (Fragment) OS=Saim... 152 5e-35
C1KES5_LEMCA (tr|C1KES5) Thymidylate synthase (Fragment) OS=Lemu... 150 2e-34
Q0U6N0_PHANO (tr|Q0U6N0) Thymidylate synthase OS=Phaeosphaeria n... 148 1e-33
A5B4I5_VITVI (tr|A5B4I5) Putative uncharacterized protein OS=Vit... 147 2e-33
B2AER4_PODAN (tr|B2AER4) Thymidylate synthase OS=Podospora anser... 145 1e-32
A3QU09_9VIRU (tr|A3QU09) Thymidylate synthase OS=Oryctes rhinoce... 140 3e-31
Q0GZJ9_9APIC (tr|Q0GZJ9) Thymidylate synthase (Fragment) OS=Plas... 139 5e-31
Q0GZJ2_PLAVN (tr|Q0GZJ2) Thymidylate synthase (Fragment) OS=Plas... 139 5e-31
Q0GZI6_PLAVN (tr|Q0GZI6) Thymidylate synthase (Fragment) OS=Plas... 139 5e-31
Q0GZJ5_PLACH (tr|Q0GZJ5) Thymidylate synthase (Fragment) OS=Plas... 139 5e-31
Q0GZJ3_PLACH (tr|Q0GZJ3) Thymidylate synthase (Fragment) OS=Plas... 139 5e-31
Q0GZJ0_PLAVN (tr|Q0GZJ0) Thymidylate synthase (Fragment) OS=Plas... 139 5e-31
Q0GZI8_PLAVN (tr|Q0GZI8) Thymidylate synthase (Fragment) OS=Plas... 139 5e-31
Q0GZI9_PLAVN (tr|Q0GZI9) Thymidylate synthase (Fragment) OS=Plas... 139 5e-31
Q0GZJ1_PLAVN (tr|Q0GZJ1) Thymidylate synthase (Fragment) OS=Plas... 137 2e-30
Q0GZI5_9APIC (tr|Q0GZI5) Thymidylate synthase (Fragment) OS=Plas... 136 5e-30
Q0GZI4_9APIC (tr|Q0GZI4) Thymidylate synthase (Fragment) OS=Plas... 136 5e-30
Q0GZI3_9APIC (tr|Q0GZI3) Thymidylate synthase (Fragment) OS=Plas... 136 5e-30
Q0GZI1_PLAYO (tr|Q0GZI1) Thymidylate synthase (Fragment) OS=Plas... 136 5e-30
Q0GZJ7_PLABE (tr|Q0GZJ7) Thymidylate synthase (Fragment) OS=Plas... 135 6e-30
C3Z0P2_BRAFL (tr|C3Z0P2) Putative uncharacterized protein OS=Bra... 134 1e-29
C6HH62_AJECH (tr|C6HH62) Thymidylate synthase OS=Ajellomyces cap... 133 4e-29
D0SPX7_ACIJU (tr|D0SPX7) Thymidylate synthase OS=Acinetobacter j... 130 3e-28
A7SCT0_NEMVE (tr|A7SCT0) Predicted protein OS=Nematostella vecte... 129 8e-28
C0VI24_9GAMM (tr|C0VI24) Thymidylate synthase OS=Acinetobacter s... 128 2e-27
A7A498_BIFAD (tr|A7A498) Thymidylate synthase OS=Bifidobacterium... 127 2e-27
C6RT35_ACIRA (tr|C6RT35) Thymidylate synthase OS=Acinetobacter r... 127 2e-27
D4XMD1_ACIHA (tr|D4XMD1) Thymidylate synthase OS=Acinetobacter h... 127 3e-27
A3M1W9_ACIBT (tr|A3M1W9) Thymidylate synthase OS=Acinetobacter b... 127 3e-27
D0CAK0_ACIBA (tr|D0CAK0) Thymidylate synthase OS=Acinetobacter b... 127 3e-27
D0BW41_9GAMM (tr|D0BW41) Thymidylate synthase OS=Acinetobacter s... 127 3e-27
Q2F5K4_BOMMO (tr|Q2F5K4) Thymidylate synthase OS=Bombyx mori PE=... 127 3e-27
B0V4P4_ACIBY (tr|B0V4P4) Thymidylate synthase OS=Acinetobacter b... 127 3e-27
B2I3A2_ACIBC (tr|B2I3A2) Thymidylate synthase OS=Acinetobacter b... 127 3e-27
B0VL69_ACIBS (tr|B0VL69) Thymidylate synthase OS=Acinetobacter b... 127 3e-27
Q4FQ50_PSYA2 (tr|Q4FQ50) Thymidylate synthase OS=Psychrobacter a... 127 3e-27
A1A0D6_BIFAA (tr|A1A0D6) Thymidylate synthase OS=Bifidobacterium... 127 3e-27
D0SSE7_ACILW (tr|D0SSE7) Thymidylate synthase OS=Acinetobacter l... 126 5e-27
A7TKP4_VANPO (tr|A7TKP4) Putative uncharacterized protein OS=Van... 126 5e-27
D3R406_BIFAB (tr|D3R406) Thymidylate synthase OS=Bifidobacterium... 126 5e-27
B4K681_DROMO (tr|B4K681) GI23507 OS=Drosophila mojavensis GN=GI2... 126 6e-27
C6AHE7_BIFAS (tr|C6AHE7) Thymidylate synthase OS=Bifidobacterium... 126 6e-27
C6A6T9_BIFLB (tr|C6A6T9) Thymidylate synthase OS=Bifidobacterium... 126 6e-27
D5TG01_BIFAV (tr|D5TG01) Thymidylate synthase OS=Bifidobacterium... 126 6e-27
B2EA10_BIFAN (tr|B2EA10) Thymidylate synthase OS=Bifidobacterium... 126 6e-27
Q172I3_AEDAE (tr|Q172I3) Putative uncharacterized protein OS=Aed... 126 6e-27
D5GD05_9PEZI (tr|D5GD05) Whole genome shotgun sequence assembly,... 125 6e-27
D3IGA2_9BACT (tr|D3IGA2) Thymidylate synthase OS=Prevotella sp. ... 125 8e-27
B8DW84_BIFA0 (tr|B8DW84) Thymidylate synthase OS=Bifidobacterium... 125 8e-27
D1NV41_9BIFI (tr|D1NV41) Thymidylate synthase OS=Bifidobacterium... 125 8e-27
Q7Q0L5_ANOGA (tr|Q7Q0L5) AGAP010278-PA OS=Anopheles gambiae GN=A... 125 1e-26
C0BQ93_9BIFI (tr|C0BQ93) Thymidylate synthase OS=Bifidobacterium... 125 1e-26
D0T6N6_ACIRA (tr|D0T6N6) Thymidylate synthase OS=Acinetobacter r... 125 1e-26
D2RA18_GARV4 (tr|D2RA18) Thymidylate synthase OS=Gardnerella vag... 124 2e-26
C9PZD9_9BACT (tr|C9PZD9) Thymidylate synthase OS=Prevotella sp. ... 124 2e-26
D0S5D1_ACICA (tr|D0S5D1) Thymidylate synthase OS=Acinetobacter c... 124 2e-26
D6JVM2_ACIG3 (tr|D6JVM2) Thymidylate synthase OS=Acinetobacter s... 124 2e-26
D5V859_MORCR (tr|D5V859) Thymidylate synthase OS=Moraxella catar... 124 2e-26
D0SD18_ACIJO (tr|D0SD18) Thymidylate synthase OS=Acinetobacter j... 124 2e-26
Q6IQS4_DANRE (tr|Q6IQS4) Dihydrofolate reductase OS=Danio rerio ... 124 2e-26
D6T0J0_GARVA (tr|D6T0J0) Thymidylate synthase OS=Gardnerella vag... 124 3e-26
D6SVW3_GARVA (tr|D6SVW3) Thymidylate synthase OS=Gardnerella vag... 124 3e-26
B6XVP2_9BIFI (tr|B6XVP2) Thymidylate synthase OS=Bifidobacterium... 124 3e-26
D3PJE0_9MAXI (tr|D3PJE0) Dihydrofolate reductase OS=Lepeophtheir... 123 3e-26
D6S015_GARVA (tr|D6S015) Thymidylate synthase OS=Gardnerella vag... 123 3e-26
A2BGQ1_DANRE (tr|A2BGQ1) Dihydrofolate reductase OS=Danio rerio ... 123 4e-26
D6KTS1_SCAIO (tr|D6KTS1) Thymidylate synthase OS=Scardovia inopi... 123 5e-26
C5MGL9_CANTT (tr|C5MGL9) Dihydrofolate reductase OS=Candida trop... 122 6e-26
Q6WEA6_9EUKA (tr|Q6WEA6) Dihydrofolate reductase OS=Hartmannella... 122 6e-26
D2Q8R2_BIFDB (tr|D2Q8R2) Thymidylate synthase OS=Bifidobacterium... 122 1e-25
B1S5R1_9BIFI (tr|B1S5R1) Thymidylate synthase OS=Bifidobacterium... 122 1e-25
B2VFU7_ERWT9 (tr|B2VFU7) Thymidylate synthase OS=Erwinia tasmani... 122 1e-25
D6L4P9_PARDN (tr|D6L4P9) Thymidylate synthase OS=Parascardovia d... 122 1e-25
Q98TR9_DANRE (tr|Q98TR9) Dihydrofolate reductase (Fragment) OS=D... 122 1e-25
C8PUX3_9GAMM (tr|C8PUX3) Thymidylate synthase OS=Enhydrobacter a... 121 1e-25
C6WWY6_METML (tr|C6WWY6) Thymidylate synthase OS=Methylotenera m... 121 1e-25
B4M4D4_DROVI (tr|B4M4D4) GJ10259 OS=Drosophila virilis GN=GJ1025... 121 1e-25
Q1LWC6_DANRE (tr|Q1LWC6) Novel protein similar to vertebrate dih... 121 1e-25
B9R0G0_9RHOB (tr|B9R0G0) Thymidylate synthase OS=Labrenzia alexa... 121 2e-25
D2QJD3_SPILD (tr|D2QJD3) Thymidylate synthase OS=Spirosoma lingu... 120 2e-25
D1XVW3_9BACT (tr|D1XVW3) Thymidylate synthase OS=Prevotella bivi... 120 2e-25
D2T644_ERWP6 (tr|D2T644) Thymidylate synthase OS=Erwinia pyrifol... 120 2e-25
D0XKH3_9CAUL (tr|D0XKH3) Thymidylate synthase OS=Brevundimonas s... 120 3e-25
A8XF85_CAEBR (tr|A8XF85) Putative uncharacterized protein OS=Cae... 120 3e-25
C9MLK5_9BACT (tr|C9MLK5) Thymidylate synthase OS=Prevotella vero... 120 3e-25
Q6WEA4_9EUKA (tr|Q6WEA4) Dihydrofolate reductase OS=Hartmannella... 120 3e-25
C4LHD3_CORK4 (tr|C4LHD3) Thymidylate synthase OS=Corynebacterium... 120 3e-25
C7ILG1_9CLOT (tr|C7ILG1) Thymidylate synthase OS=Clostridium pap... 120 3e-25
D4BQZ3_BIFBR (tr|D4BQZ3) Thymidylate synthase OS=Bifidobacterium... 120 4e-25
D0FVF8_ERWPY (tr|D0FVF8) Thymidylate synthase OS=Erwinia pyrifol... 120 4e-25
A4KQP6_FRATU (tr|A4KQP6) Thymidylate synthase OS=Francisella tul... 119 5e-25
Q6WEA8_9EUKA (tr|Q6WEA8) Dihydrofolate reductase OS=Hartmannella... 119 5e-25
D4I9X7_ERWAE (tr|D4I9X7) Thymidylate synthase OS=Erwinia amylovo... 119 5e-25
D4HWH7_ERWAC (tr|D4HWH7) Thymidylate synthase OS=Erwinia amylovo... 119 5e-25
A7YT26_FRATU (tr|A7YT26) Putative uncharacterized protein OS=Fra... 119 5e-25
D0VXF0_9VIRU (tr|D0VXF0) Putative uncharacterized protein thsP O... 119 5e-25
B3DQJ6_BIFLD (tr|B3DQJ6) Thymidylate synthase OS=Bifidobacterium... 119 6e-25
D6ZW37_BIFLO (tr|D6ZW37) Thymidylate synthase OS=Bifidobacterium... 119 6e-25
D6DBZ2_BIFLO (tr|D6DBZ2) Thymidylate synthase OS=Bifidobacterium... 119 6e-25
D4W573_9FIRM (tr|D4W573) Thymidylate synthase OS=Turicibacter sp... 119 6e-25
D3IEM8_9BACT (tr|D3IEM8) Thymidylate synthase OS=Prevotella sp. ... 119 6e-25
C5VHR1_9BACT (tr|C5VHR1) Thymidylate synthase OS=Prevotella mela... 119 6e-25
C2GVD6_BIFLO (tr|C2GVD6) Thymidylate synthase OS=Bifidobacterium... 119 6e-25
B7GUQ7_BIFLI (tr|B7GUQ7) Thymidylate synthase OS=Bifidobacterium... 119 7e-25
C5EBA8_BIFLO (tr|C5EBA8) Thymidylate synthase OS=Bifidobacterium... 119 7e-25
D7DQB5_9PROT (tr|D7DQB5) Thymidylate synthase OS=Methylotenera s... 119 8e-25
D1W221_9BACT (tr|D1W221) Thymidylate synthase OS=Prevotella timo... 119 9e-25
Q296C6_DROPS (tr|Q296C6) GA13324 OS=Drosophila pseudoobscura pse... 119 9e-25
C5SJ38_9CAUL (tr|C5SJ38) Thymidylate synthase OS=Asticcacaulis e... 119 9e-25
C4SKK1_YERFR (tr|C4SKK1) Thymidylate synthase OS=Yersinia freder... 119 1e-24
B5JTJ1_9GAMM (tr|B5JTJ1) Thymidylate synthase OS=gamma proteobac... 118 1e-24
D3I1E6_9BACT (tr|D3I1E6) Thymidylate synthase OS=Prevotella bucc... 118 1e-24
D2AP29_FRATE (tr|D2AP29) Thymidylate synthase OS=Francisella tul... 118 1e-24
C6YQC7_FRATT (tr|C6YQC7) Thymidylate synthase OS=Francisella tul... 118 1e-24
A7JD81_FRATT (tr|A7JD81) Thymidylate synthase OS=Francisella tul... 118 1e-24
B2SG33_FRATM (tr|B2SG33) Thymidylate synthase OS=Francisella tul... 118 1e-24
B4ARC7_FRANO (tr|B4ARC7) Thymidylate synthase OS=Francisella nov... 118 1e-24
A8TM81_9PROT (tr|A8TM81) Thymidylate synthase OS=alpha proteobac... 118 1e-24
A7JMS6_FRANO (tr|A7JMS6) Thymidylate synthase OS=Francisella nov... 118 1e-24
A7JIN0_FRANO (tr|A7JIN0) Thymidylate synthase OS=Francisella nov... 118 1e-24
C4UVK9_YERRO (tr|C4UVK9) Thymidylate synthase OS=Yersinia rohdei... 118 1e-24
Q2B1Y3_9BACI (tr|Q2B1Y3) Thymidylate synthase OS=Bacillus sp. NR... 118 1e-24
A9DJL8_9FLAO (tr|A9DJL8) Thymidylate synthase OS=Kordia algicida... 118 1e-24
B9WKH7_CANDC (tr|B9WKH7) Dihydrofolate reductase, putative OS=Ca... 118 1e-24
Q5A5E0_CANAL (tr|Q5A5E0) Putative uncharacterized protein CaJ7.0... 118 2e-24
D5DPX1_BACMQ (tr|D5DPX1) Thymidylate synthase OS=Bacillus megate... 118 2e-24
D5DJI4_BACMD (tr|D5DJI4) Thymidylate synthase OS=Bacillus megate... 118 2e-24
Q6BTR6_DEBHA (tr|Q6BTR6) DEHA2C16456p OS=Debaryomyces hansenii G... 118 2e-24
B4BMP9_9BACI (tr|B4BMP9) Thymidylate synthase OS=Geobacillus sp.... 118 2e-24
D1RZK6_SEROD (tr|D1RZK6) Thymidylate synthase OS=Serratia odorif... 117 2e-24
D3E9M6_GEOS4 (tr|D3E9M6) Thymidylate synthase OS=Geobacillus sp.... 117 2e-24
A7LS81_BACOV (tr|A7LS81) Thymidylate synthase OS=Bacteroides ova... 117 2e-24
B2GI61_KOCRD (tr|B2GI61) Thymidylate synthase OS=Kocuria rhizoph... 117 2e-24
D1W8T0_9BACT (tr|D1W8T0) Thymidylate synthase OS=Prevotella bucc... 117 2e-24
C7PKU7_CHIPD (tr|C7PKU7) Thymidylate synthase OS=Chitinophaga pi... 117 2e-24
C0BFU6_9BACT (tr|C0BFU6) Thymidylate synthase OS=Flavobacteria b... 117 2e-24
A4C6J4_9GAMM (tr|A4C6J4) Thymidylate synthase OS=Pseudoalteromon... 117 3e-24
C4FGJ1_9BIFI (tr|C4FGJ1) Thymidylate synthase OS=Bifidobacterium... 117 3e-24
B9Z6P9_9NEIS (tr|B9Z6P9) Thymidylate synthase OS=Lutiella nitrof... 117 3e-24
B3JMT5_9BACE (tr|B3JMT5) Thymidylate synthase OS=Bacteroides cop... 117 3e-24
B4RGA9_PHEZH (tr|B4RGA9) Thymidylate synthase OS=Phenylobacteriu... 117 3e-24
A3J2D5_9FLAO (tr|A3J2D5) Thymidylate synthetase OS=Flavobacteria... 117 3e-24
A2TSB9_9FLAO (tr|A2TSB9) Thymidylate synthase OS=Dokdonia dongha... 117 3e-24
A3LSL9_PICST (tr|A3LSL9) Dihydrofolate reductase OS=Pichia stipi... 117 3e-24
D0LYN1_HALO1 (tr|D0LYN1) Dihydrofolate reductase OS=Haliangium o... 117 4e-24
B1YHM0_EXIS2 (tr|B1YHM0) Thymidylate synthase OS=Exiguobacterium... 117 4e-24
C4SAP0_YERMO (tr|C4SAP0) Thymidylate synthase OS=Yersinia mollar... 117 4e-24
C4RZL5_YERBE (tr|C4RZL5) Thymidylate synthase OS=Yersinia bercov... 117 4e-24
C7RLL6_ACCPU (tr|C7RLL6) Thymidylate synthase OS=Accumulibacter ... 117 4e-24
D0ZCR9_EDWTE (tr|D0ZCR9) Thymidylate synthase OS=Edwardsiella ta... 116 4e-24
A6M9A2_9VIRU (tr|A6M9A2) Thymidylate synthase OS=Geobacillus vir... 116 4e-24
D4Y6J5_BACTR (tr|D4Y6J5) Thymidylate synthase OS=Geobacillus the... 116 5e-24
C6QQX1_9BACI (tr|C6QQX1) Thymidylate synthase OS=Geobacillus sp.... 116 5e-24
C7NFY4_KYTSD (tr|C7NFY4) Thymidylate synthase OS=Kytococcus sede... 116 5e-24
D3I4M8_9BACT (tr|D3I4M8) Thymidylate synthase OS=Prevotella mela... 116 5e-24
Q6WEA2_9EUKA (tr|Q6WEA2) Dihydrofolate reductase OS=Hartmannella... 116 5e-24
C9LK51_9BACT (tr|C9LK51) Thymidylate synthase OS=Prevotella tann... 116 5e-24
C9RST5_GEOSY (tr|C9RST5) Thymidylate synthase OS=Geobacillus sp.... 116 6e-24
D7D6N1_9BACI (tr|D7D6N1) Thymidylate synthase OS=Geobacillus sp.... 116 6e-24
C3J3G5_9BACI (tr|C3J3G5) Thymidylate synthase OS=Geobacillus sp.... 116 6e-24
D3HNP9_LEGLN (tr|D3HNP9) Thymidylate synthase OS=Legionella long... 116 6e-24
D1RCM1_LEGLO (tr|D1RCM1) Thymidylate synthase OS=Legionella long... 116 6e-24
C0ENR5_NEIFL (tr|C0ENR5) Thymidylate synthase OS=Neisseria flave... 116 6e-24
D5TAS9_LEGP2 (tr|D5TAS9) Thymidylate synthase OS=Legionella pneu... 116 6e-24
B4GFC1_DROPE (tr|B4GFC1) GL22182 OS=Drosophila persimilis GN=GL2... 116 6e-24
D2BTT4_DICD5 (tr|D2BTT4) Thymidylate synthase OS=Dickeya dadanti... 116 6e-24
C6XT75_PEDHD (tr|C6XT75) Thymidylate synthase OS=Pedobacter hepa... 115 7e-24
D4GLM8_PANAM (tr|D4GLM8) Thymidylate synthase OS=Pantoea ananati... 115 8e-24
B0X1Y0_CULQU (tr|B0X1Y0) Dihydrofolate reductase OS=Culex quinqu... 115 8e-24
D6Y174_9BACI (tr|D6Y174) Thymidylate synthase OS=Bacillus seleni... 115 8e-24
C6YV91_9GAMM (tr|C6YV91) Thymidylate synthase OS=Francisella phi... 115 8e-24
C1PFX2_BACCO (tr|C1PFX2) Thymidylate synthase OS=Bacillus coagul... 115 8e-24
C2M2G3_CAPGI (tr|C2M2G3) Thymidylate synthase OS=Capnocytophaga ... 115 9e-24
C6MYR2_9GAMM (tr|C6MYR2) Thymidylate synthase OS=Legionella dran... 115 9e-24
A2U3N0_9FLAO (tr|A2U3N0) Thymidylate synthase OS=Polaribacter sp... 115 9e-24
D3V580_XENBS (tr|D3V580) Thymidylate synthase OS=Xenorhabdus bov... 115 1e-23
B2JZ66_YERPB (tr|B2JZ66) Thymidylate synthase OS=Yersinia pseudo... 115 1e-23
B1JQD0_YERPY (tr|B1JQD0) Thymidylate synthase OS=Yersinia pseudo... 115 1e-23
D5B348_YERPZ (tr|D5B348) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
D0JRG6_YERP1 (tr|D0JRG6) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
D0JGZ7_YERPD (tr|D0JGZ7) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
A9R2R3_YERPG (tr|A9R2R3) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
D1TR63_YERPE (tr|D1TR63) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
C4HSA2_YERPE (tr|C4HSA2) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
C4HKY8_YERPE (tr|C4HKY8) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
C4H1V2_YERPE (tr|C4H1V2) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
B0HVD9_YERPE (tr|B0HVD9) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
B0HJ19_YERPE (tr|B0HJ19) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
B0H6U1_YERPE (tr|B0H6U1) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
B0GN04_YERPE (tr|B0GN04) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
B0GF93_YERPE (tr|B0GF93) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
A9ZVK0_YERPE (tr|A9ZVK0) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
A9ZBT1_YERPE (tr|A9ZBT1) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
A6BU91_YERPE (tr|A6BU91) Thymidylate synthase OS=Yersinia pestis... 115 1e-23
D4DQP9_NEIEG (tr|D4DQP9) Thymidylate synthase OS=Neisseria elong... 115 1e-23
D7IN08_9BACE (tr|D7IN08) Thymidylate synthase OS=Bacteroides sp.... 115 1e-23
D0TD33_9BACE (tr|D0TD33) Thymidylate synthase OS=Bacteroides sp.... 115 1e-23
C7X689_9PORP (tr|C7X689) Thymidylate synthase OS=Parabacteroides... 115 1e-23
C6S8E7_NEIML (tr|C6S8E7) Thymidylate synthase OS=Neisseria menin... 115 1e-23
C9XZK0_CROTZ (tr|C9XZK0) Thymidylate synthase OS=Cronobacter tur... 115 1e-23
B6C320_9GAMM (tr|B6C320) Thymidylate synthase OS=Nitrosococcus o... 115 1e-23
D4E298_SEROD (tr|D4E298) Thymidylate synthase OS=Serratia odorif... 115 1e-23
C3JBM4_9PORP (tr|C3JBM4) Thymidylate synthase OS=Porphyromonas e... 115 1e-23
C4WF15_9RHIZ (tr|C4WF15) Thymidylate synthase OS=Ochrobactrum in... 115 1e-23
D7K692_9BACE (tr|D7K692) Thymidylate synthase OS=Bacteroides sp.... 115 1e-23
D4WLQ3_BACOV (tr|D4WLQ3) Thymidylate synthase OS=Bacteroides ova... 115 1e-23
C3QWY7_9BACE (tr|C3QWY7) Thymidylate synthase OS=Bacteroides sp.... 115 1e-23
C9WY25_NEIM8 (tr|C9WY25) Thymidylate synthase OS=Neisseria menin... 115 1e-23
C6SGI5_NEIME (tr|C6SGI5) Thymidylate synthase OS=Neisseria menin... 115 1e-23
A6DH02_9BACT (tr|A6DH02) Thymidylate synthase OS=Lentisphaera ar... 115 1e-23
D1CYY6_9RHIZ (tr|D1CYY6) Thymidylate synthase OS=Brucella sp. 83... 115 1e-23
B6R006_9RHOB (tr|B6R006) Thymidylate synthase OS=Pseudovibrio sp... 115 1e-23
>B9H0T4_POPTR (tr|B9H0T4) Dihydrofolate reductase-thymidylate synthase OS=Populus
trichocarpa GN=DHFR-TS-1 PE=4 SV=1
Length = 528
Score = 679 bits (1751), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 324/380 (85%), Positives = 346/380 (91%), Gaps = 3/380 (0%)
Query: 40 MAGDSKASLSNGTANIQ-SDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLT 98
M+GDS A+LSNG AN Q SDPR+TYQVVVAAT+DMGIGK+GKLPW+LPSDLKFFKD+TLT
Sbjct: 1 MSGDSVANLSNGNANTQQSDPRKTYQVVVAATKDMGIGKDGKLPWKLPSDLKFFKDLTLT 60
Query: 99 TSDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
T DSG+KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICG
Sbjct: 61 TMDSGKKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGSMGSALE 120
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
PYCLSIEKVF+IGGGQILRESLNAPGCDAIHITEIET DCDTFIP ID+SVFQP
Sbjct: 121 LLAASPYCLSIEKVFVIGGGQILRESLNAPGCDAIHITEIETDFDCDTFIPAIDTSVFQP 180
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSD--NSYIKFEVKKFSFLPKMVF 276
WYSSFP VEN++R+CF TYVRVR S +ESH Q+NG +SD + KFEVKKFSFLPKMVF
Sbjct: 181 WYSSFPKVENDIRHCFTTYVRVRSSTIESHSQNNGENSDGNSENSKFEVKKFSFLPKMVF 240
Query: 277 ERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVV 336
ERHEE+LYLR+VQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR+ FPLLTTKKVFWRGVV
Sbjct: 241 ERHEEYLYLRMVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRKNFPLLTTKKVFWRGVV 300
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWFISGST+ KVLQEKGIHIWDGNASR+YLD IGLKDREEGDLGPVYGFQWRHFGAR
Sbjct: 301 EELLWFISGSTSAKVLQEKGIHIWDGNASREYLDSIGLKDREEGDLGPVYGFQWRHFGAR 360
Query: 397 YTDMHADYTGQGFDQLLDVI 416
YTDMHADYTGQGFDQLLDVI
Sbjct: 361 YTDMHADYTGQGFDQLLDVI 380
>B9RH79_RICCO (tr|B9RH79) Bifunctional dihydrofolate reductase-thymidylate
synthase, putative OS=Ricinus communis GN=RCOM_1447960
PE=4 SV=1
Length = 528
Score = 676 bits (1745), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 325/380 (85%), Positives = 348/380 (91%), Gaps = 3/380 (0%)
Query: 40 MAGDSKASLSNGTANI-QSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLT 98
MAGD+KA+LSNG ANI Q DPRRTYQVVVAATRDMGIGK+GKLPWRLPSDLKFFKDVTLT
Sbjct: 1 MAGDTKANLSNGNANIEQHDPRRTYQVVVAATRDMGIGKDGKLPWRLPSDLKFFKDVTLT 60
Query: 99 TSDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
T+DSG+KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVV+CG
Sbjct: 61 TTDSGKKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVMCGSFASALE 120
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
PYCLSIEKV++IGGGQILRE+LNAPGCDA+HITEIETS DCDTFIP IDSS+F P
Sbjct: 121 LLAASPYCLSIEKVYVIGGGQILREALNAPGCDAVHITEIETSFDCDTFIPAIDSSIFHP 180
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGL--SSDNSYIKFEVKKFSFLPKMVF 276
WY SFP+VENN+RY FATYVRVR SAVES+G D+GL S + KF+VKKFSFLPKMVF
Sbjct: 181 WYLSFPMVENNIRYSFATYVRVRSSAVESNGHDSGLSSESSSENSKFDVKKFSFLPKMVF 240
Query: 277 ERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVV 336
+RHEEFLYLRLVQ+IISDG LKDDRTGTGTLSKFGCQ+RFNLR+TFPLLTTKKVFWRGVV
Sbjct: 241 DRHEEFLYLRLVQEIISDGILKDDRTGTGTLSKFGCQVRFNLRKTFPLLTTKKVFWRGVV 300
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWFISGSTN KVLQEKGIHIWDGNASRDYLD IGLK+REEGDLGPVYGFQWRHFGAR
Sbjct: 301 EELLWFISGSTNAKVLQEKGIHIWDGNASRDYLDSIGLKNREEGDLGPVYGFQWRHFGAR 360
Query: 397 YTDMHADYTGQGFDQLLDVI 416
YTDMHADYTGQGFDQLLDV+
Sbjct: 361 YTDMHADYTGQGFDQLLDVV 380
>D7U4L1_VITVI (tr|D7U4L1) Whole genome shotgun sequence of line PN40024,
scaffold_38.assembly12x (Fragment) OS=Vitis vinifera
GN=VIT_00023812001 PE=4 SV=1
Length = 608
Score = 642 bits (1657), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 308/406 (75%), Positives = 337/406 (83%), Gaps = 23/406 (5%)
Query: 11 VLKNFCKSWVYTVSSEVPSSNFCLAFFSNMAGDSKASLSNGTANIQSDPRRTYQVVVAAT 70
VL +FCKSW+ ++S + S + S MA D+ SL NG ANIQ DP+RTYQVVVAAT
Sbjct: 78 VLLHFCKSWLCSLSFQSTSLSLHWVQDSIMASDTVVSLPNGNANIQPDPQRTYQVVVAAT 137
Query: 71 RDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEHRPLPGRLN 130
RDMGIGK+GKLPWRLPSD+K FKD+T+T +D+ +KNAVIMGRKTWESIPLEHRPLPGRLN
Sbjct: 138 RDMGIGKDGKLPWRLPSDMKIFKDITMTVADTVKKNAVIMGRKTWESIPLEHRPLPGRLN 197
Query: 131 VVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGC 190
VVLTRSGSFDIATAENVVICG PYCLSIEKVF+IGGGQILRE+LNAPGC
Sbjct: 198 VVLTRSGSFDIATAENVVICGSMASALELLAASPYCLSIEKVFVIGGGQILREALNAPGC 257
Query: 191 DAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQ 250
DAIHITEIETS +CDTFIP IDS VFQPWYSSFP+VENN+RY F TYVRVR
Sbjct: 258 DAIHITEIETSFECDTFIPAIDSLVFQPWYSSFPLVENNIRYSFMTYVRVR--------- 308
Query: 251 DNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKF 310
+KKFSFLPKM+FERHEE++YLRLV+DIIS+G +DDRTGTGTLSKF
Sbjct: 309 --------------IKKFSFLPKMIFERHEEYIYLRLVEDIISNGVQRDDRTGTGTLSKF 354
Query: 311 GCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLD 370
GCQMRFNLR+TFPLLTTKKVFWRGVVEELLWFISGSTN KVLQEKGIHIWDGNASRDYLD
Sbjct: 355 GCQMRFNLRKTFPLLTTKKVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASRDYLD 414
Query: 371 GIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
IGL DREEGDLGP+YGFQWRHFGA Y DMHADYTGQGFDQLLDVI
Sbjct: 415 SIGLADREEGDLGPIYGFQWRHFGASYIDMHADYTGQGFDQLLDVI 460
>Q39687_DAUCA (tr|Q39687) Dihydrofolate reductase-thymidylate synthetase
OS=Daucus carota GN=DHFR-TS PE=4 SV=2
Length = 577
Score = 611 bits (1575), Expect = e-173, Method: Compositional matrix adjust.
Identities = 291/417 (69%), Positives = 339/417 (81%), Gaps = 4/417 (0%)
Query: 4 LIALLFQVLKNFCKSWVYTVSSEVPSSNF--CLAFFSNMAGDSKASLSNGTANIQSDPRR 61
L+ L Q L S + + SSNF C F + MA + A+ +NG+ + DP+R
Sbjct: 12 LLNSLSQTLALRSASLYLLTNCNLSSSNFSHCHRFTTYMASERLANPTNGSGITRPDPQR 71
Query: 62 TYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLE 121
TYQVVVAAT++MGIGK+GKLPWRLPSD+KFFKDVT+TTSD ++NAVIMGRKTWESIP++
Sbjct: 72 TYQVVVAATQNMGIGKDGKLPWRLPSDMKFFKDVTMTTSDPLKRNAVIMGRKTWESIPIQ 131
Query: 122 HRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQIL 181
HRPLPGRLNVVLTRSGSFDIAT ENVVICG PYC+S+EKVF+IGGGQI
Sbjct: 132 HRPLPGRLNVVLTRSGSFDIATVENVVICGSMISALELLAGSPYCVSVEKVFVIGGGQIY 191
Query: 182 RESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVR 241
RE+LNAPGCDA+HITEIE I+CDTFIP +D SVFQPWYSSFP+VEN +RYCF TYVRVR
Sbjct: 192 REALNAPGCDAVHITEIEEHIECDTFIPLLDESVFQPWYSSFPLVENKIRYCFTTYVRVR 251
Query: 242 VSAVESHGQDNGLSSDNSYI--KFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKD 299
S E Q NG SSD+ FE++ FSFLPK VFE+HEE+LYL LV++IIS+G K+
Sbjct: 252 NSVAELTSQTNGCSSDSKSDSGNFEIQNFSFLPKTVFEKHEEYLYLGLVENIISNGVTKN 311
Query: 300 DRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHI 359
DRT TGT+S FGCQMRFNLR++FPLLTTKKVFWRGVVEELLWFISGSTN K+L+EKG++I
Sbjct: 312 DRTRTGTVSIFGCQMRFNLRKSFPLLTTKKVFWRGVVEELLWFISGSTNAKILKEKGVNI 371
Query: 360 WDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
W+GN SR+YLD IGL DREEGDLGP+YGFQWRHFGARYTDMHADY+GQGFDQLLDVI
Sbjct: 372 WEGNGSREYLDSIGLTDREEGDLGPIYGFQWRHFGARYTDMHADYSGQGFDQLLDVI 428
>D7L1V0_ARALY (tr|D7L1V0) Dihydrofolate reductase-thymidylate synthase
OS=Arabidopsis lyrata subsp. lyrata GN=ARALYDRAFT_480800
PE=4 SV=1
Length = 515
Score = 586 bits (1510), Expect = e-165, Method: Compositional matrix adjust.
Identities = 271/367 (73%), Positives = 315/367 (85%), Gaps = 8/367 (2%)
Query: 50 NGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVI 109
N T + S+P+RTYQVVVAAT++MGIGK+GKLPW LP+DLKFFKD+TLTTSDS +KNAV+
Sbjct: 9 NDTTRLASEPQRTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDITLTTSDSSKKNAVV 68
Query: 110 MGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSI 169
MGRKTWE+IP++HRPL GRLNVVLTRSG FDIA ENVV C PYCLSI
Sbjct: 69 MGRKTWEAIPIKHRPLSGRLNVVLTRSGGFDIANTENVVTCSSVDSALDLLAAPPYCLSI 128
Query: 170 EKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENN 229
E+VF+IGGG ILRE+LN P CDAIH+TEI+TSI+CDTFIP +D+SV+QPW SSFP+ EN
Sbjct: 129 ERVFVIGGGDILREALNRPSCDAIHLTEIDTSIECDTFIPAVDTSVYQPWCSSFPVTENG 188
Query: 230 VRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQ 289
+R+CF T+VRV+ S ES+ + ++F+ KKF FLPKMVF++HEEFLYL +V+
Sbjct: 189 LRFCFTTFVRVKSSTDESNVSQS--------LQFDGKKFLFLPKMVFDQHEEFLYLNMVE 240
Query: 290 DIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNC 349
DIIS+GN K+DRTGTGTLSKFGCQM+FNLRR+FPLLTTK+VFWRGVVEELLWFISGSTN
Sbjct: 241 DIISNGNAKNDRTGTGTLSKFGCQMKFNLRRSFPLLTTKRVFWRGVVEELLWFISGSTNA 300
Query: 350 KVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGF 409
KVLQEKGIHIWDGNASR+YLDGIGL +REEGDLGPVYGFQWRHFGA+YTDMHADYTGQGF
Sbjct: 301 KVLQEKGIHIWDGNASREYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGF 360
Query: 410 DQLLDVI 416
DQLLDVI
Sbjct: 361 DQLLDVI 367
>B0BLI5_LOTJA (tr|B0BLI5) CM0216.390.nc protein OS=Lotus japonicus
GN=CM0216.390.nc PE=4 SV=1
Length = 528
Score = 585 bits (1509), Expect = e-165, Method: Compositional matrix adjust.
Identities = 281/381 (73%), Positives = 321/381 (84%), Gaps = 5/381 (1%)
Query: 40 MAGDSKASLSNG--TANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL 97
MA DS +SNG N++ P+RTYQ VV AT DMGI K+GKLPW LP+D KFF+++T
Sbjct: 1 MASDSLV-ISNGHDNGNLELSPQRTYQAVVIATPDMGISKDGKLPWALPTDQKFFEEITT 59
Query: 98 TTSDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXX 157
TSD G+KNAV+MGRK+WE+IP E RPL GRLNVVLTRSGSFDIATAENVVICG
Sbjct: 60 KTSDPGKKNAVVMGRKSWEAIPPEKRPLCGRLNVVLTRSGSFDIATAENVVICGSVSSAM 119
Query: 158 XXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQ 217
PY +SIEKVF+ GGG+I RE+LNAPGC+A+HITEIE SI+CDTF+P++D SVF
Sbjct: 120 ELLASSPYSMSIEKVFLTGGGEIFREALNAPGCEAVHITEIEASIECDTFMPRVDFSVFH 179
Query: 218 PWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSY--IKFEVKKFSFLPKMV 275
PWYSSFP+VENN+RY F TYVRVR SA ES GQ+ S D+ +KFEVKKFSFLPKM+
Sbjct: 180 PWYSSFPLVENNIRYSFNTYVRVRSSAEESLGQNTDPSFDSDSDSLKFEVKKFSFLPKMI 239
Query: 276 FERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGV 335
FE HEE+ YLRLVQ+IIS+G +KDDRTGTGTLSKFGCQMRFNLRR+FPLLTTKKVFWRGV
Sbjct: 240 FESHEEYKYLRLVQEIISEGTVKDDRTGTGTLSKFGCQMRFNLRRSFPLLTTKKVFWRGV 299
Query: 336 VEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGA 395
VEELLWFISGST+ KVLQEKGIHIWDGNASR+YLD IGL +REEGDLGPVYGFQWRHFGA
Sbjct: 300 VEELLWFISGSTSAKVLQEKGIHIWDGNASREYLDSIGLTEREEGDLGPVYGFQWRHFGA 359
Query: 396 RYTDMHADYTGQGFDQLLDVI 416
RYT+MH DY+G+GFDQLLDVI
Sbjct: 360 RYTNMHDDYSGKGFDQLLDVI 380
>C5Y2E9_SORBI (tr|C5Y2E9) Putative uncharacterized protein Sb05g016730 OS=Sorghum
bicolor GN=Sb05g016730 PE=4 SV=1
Length = 521
Score = 578 bits (1489), Expect = e-163, Method: Compositional matrix adjust.
Identities = 270/374 (72%), Positives = 314/374 (83%), Gaps = 6/374 (1%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRK 105
A+ +NG + QS P+R YQVVVAATRDMGIGK+G LPW+L DLKFFK++TLTTSD +K
Sbjct: 3 AAPANGDS--QSGPQRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTLTTSDPAKK 60
Query: 106 NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPY 165
NAVIMGRKTWESIP++ RPLPGRLNV+LTRSGSFD AT ENVVICG PY
Sbjct: 61 NAVIMGRKTWESIPVKSRPLPGRLNVILTRSGSFDFATVENVVICGSMNSALELLASTPY 120
Query: 166 CLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPI 225
CLSIEKVF++GGGQ+LRE LN P C+AIH+T+I++SI+CDTFIP +D SVFQPWYSSFP+
Sbjct: 121 CLSIEKVFVVGGGQVLREYLNGPACEAIHLTDIQSSIECDTFIPPVDFSVFQPWYSSFPV 180
Query: 226 VENNVRYCFATYVRVRVSAVESHGQDNGLSS---DNSYIKFEVKKFSFLPKMVFERHEEF 282
VE+N+R+ F T+VRVR S E+H + NG S D KFE++ FSFLP+MV++RHEE+
Sbjct: 181 VESNIRHSFVTFVRVRKSVAETH-ESNGKESTEVDTKNDKFEIENFSFLPEMVYDRHEEY 239
Query: 283 LYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWF 342
YL LV+DII G K+DRTGTGT+SKFGCQMRFNLR+ FPLLTTK+VFWRGVVEELLWF
Sbjct: 240 QYLNLVEDIIRSGAQKNDRTGTGTMSKFGCQMRFNLRKNFPLLTTKRVFWRGVVEELLWF 299
Query: 343 ISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHA 402
ISGSTN KVLQEKGIHIWDGNASR+YLD +GL REEGDLGPVYGFQWRHFGA YTDMHA
Sbjct: 300 ISGSTNAKVLQEKGIHIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAEYTDMHA 359
Query: 403 DYTGQGFDQLLDVI 416
DYTG+GFDQL+DVI
Sbjct: 360 DYTGKGFDQLMDVI 373
>Q8L6F0_PEA (tr|Q8L6F0) Dihydrofolate reductase-thymidylate synthase OS=Pisum
sativum GN=dhfrts1 PE=2 SV=1
Length = 530
Score = 577 bits (1486), Expect = e-162, Method: Compositional matrix adjust.
Identities = 273/382 (71%), Positives = 310/382 (81%), Gaps = 5/382 (1%)
Query: 40 MAGDSKASLS---NGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVT 96
MA DS + NG+ N + +RTYQVVVAAT+DMGIGK+GKLPWRLP+DLKFFK++T
Sbjct: 1 MAADSSVMFNGNGNGSINPMPNLQRTYQVVVAATKDMGIGKDGKLPWRLPTDLKFFKELT 60
Query: 97 LTTSDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXX 156
TT ++G+KNA++MGRKTWESIPL+ RPLPGRLNVVLTRSGSFD AENVVICG
Sbjct: 61 TTTFETGKKNAIVMGRKTWESIPLQFRPLPGRLNVVLTRSGSFDAKAAENVVICGSMSSA 120
Query: 157 XXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVF 216
PYC SIEK+F+IGGG+I R++LN P C+AIHITEI TS +CDTF+P ID + F
Sbjct: 121 LELLAASPYCTSIEKIFVIGGGEIFRDALNVPECEAIHITEIHTSFECDTFMPPIDFTTF 180
Query: 217 QPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDN--SYIKFEVKKFSFLPKM 274
+PWYSSFP VENN+RY F TYVRVR S ES Q DN + KFEV+ FSFLPKM
Sbjct: 181 RPWYSSFPKVENNIRYSFTTYVRVRSSVAESLNQSTVSPLDNKPASKKFEVQNFSFLPKM 240
Query: 275 VFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRG 334
+FERHEE++YL LVQ+IIS G K DRTGTGTLSKFGCQMRFNLRR FPLLTTK+VFWRG
Sbjct: 241 IFERHEEYMYLNLVQEIISQGTSKGDRTGTGTLSKFGCQMRFNLRRGFPLLTTKRVFWRG 300
Query: 335 VVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFG 394
VVEELLWFISGSTN KVLQEKGIHIWD NASR++LD IGL +REEGDLGPVYGFQWRHFG
Sbjct: 301 VVEELLWFISGSTNAKVLQEKGIHIWDDNASREFLDSIGLSEREEGDLGPVYGFQWRHFG 360
Query: 395 ARYTDMHADYTGQGFDQLLDVI 416
ARYT+MH DY GQG DQLLDVI
Sbjct: 361 ARYTNMHNDYAGQGVDQLLDVI 382
>B9GAQ2_ORYSJ (tr|B9GAQ2) Putative uncharacterized protein OS=Oryza sativa subsp.
japonica GN=OsJ_33908 PE=4 SV=1
Length = 574
Score = 574 bits (1480), Expect = e-162, Method: Compositional matrix adjust.
Identities = 269/373 (72%), Positives = 313/373 (83%), Gaps = 6/373 (1%)
Query: 47 SLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKN 106
+LSNG + Q+ P+R YQVVVAATRDMGIGK+G LPW+L DLKFFK++T+TT+D +KN
Sbjct: 4 TLSNGVS--QNGPQRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTVTTADPVKKN 61
Query: 107 AVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYC 166
AVIMGRKTWES+PL+ RPLPGRLN++LTRSGSF+ AT ENVVICG PYC
Sbjct: 62 AVIMGRKTWESLPLKARPLPGRLNIILTRSGSFEFATVENVVICGSMNSALELLSSTPYC 121
Query: 167 LSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIV 226
LSIEKVF+IGGGQ+LRESLN P C+A+H+T+I++SI+CDTFIP ID SVFQPWYSS P+V
Sbjct: 122 LSIEKVFVIGGGQVLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLSVFQPWYSSLPVV 181
Query: 227 ENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYI---KFEVKKFSFLPKMVFERHEEFL 283
E+N+R+ F TYVRVR + E+H NG S N I KFE + FSFLPK++F+RHEE+
Sbjct: 182 ESNIRHSFVTYVRVRKTMAETH-DSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEYH 240
Query: 284 YLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFI 343
YL LV+DII G K+DRTGTGTLSKFGCQMRFNLR +FPLLTTKKVFWRGVVEELLWFI
Sbjct: 241 YLNLVEDIIRSGAQKNDRTGTGTLSKFGCQMRFNLRNSFPLLTTKKVFWRGVVEELLWFI 300
Query: 344 SGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHAD 403
SGST+ KVLQEKGIHIWDGNASR+YLD +GL REEGDLGPVYGFQWRHFGA YTDMHAD
Sbjct: 301 SGSTSAKVLQEKGIHIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAEYTDMHAD 360
Query: 404 YTGQGFDQLLDVI 416
YTG+GFDQL+DVI
Sbjct: 361 YTGKGFDQLMDVI 373
>Q2R481_ORYSJ (tr|Q2R481) Bifunctional dihydrofolate reductase-thymidylate
synthase, putative, expressed OS=Oryza sativa subsp.
japonica GN=LOC_Os11g29390 PE=4 SV=1
Length = 521
Score = 573 bits (1478), Expect = e-161, Method: Compositional matrix adjust.
Identities = 269/373 (72%), Positives = 313/373 (83%), Gaps = 6/373 (1%)
Query: 47 SLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKN 106
+LSNG + Q+ P+R YQVVVAATRDMGIGK+G LPW+L DLKFFK++T+TT+D +KN
Sbjct: 4 TLSNGVS--QNGPQRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTVTTADPVKKN 61
Query: 107 AVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYC 166
AVIMGRKTWES+PL+ RPLPGRLN++LTRSGSF+ AT ENVVICG PYC
Sbjct: 62 AVIMGRKTWESLPLKARPLPGRLNIILTRSGSFEFATVENVVICGSMNSALELLSSTPYC 121
Query: 167 LSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIV 226
LSIEKVF+IGGGQ+LRESLN P C+A+H+T+I++SI+CDTFIP ID SVFQPWYSS P+V
Sbjct: 122 LSIEKVFVIGGGQVLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLSVFQPWYSSLPVV 181
Query: 227 ENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYI---KFEVKKFSFLPKMVFERHEEFL 283
E+N+R+ F TYVRVR + E+H NG S N I KFE + FSFLPK++F+RHEE+
Sbjct: 182 ESNIRHSFVTYVRVRKTMAETH-DSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEYH 240
Query: 284 YLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFI 343
YL LV+DII G K+DRTGTGTLSKFGCQMRFNLR +FPLLTTKKVFWRGVVEELLWFI
Sbjct: 241 YLNLVEDIIRSGAQKNDRTGTGTLSKFGCQMRFNLRNSFPLLTTKKVFWRGVVEELLWFI 300
Query: 344 SGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHAD 403
SGST+ KVLQEKGIHIWDGNASR+YLD +GL REEGDLGPVYGFQWRHFGA YTDMHAD
Sbjct: 301 SGSTSAKVLQEKGIHIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAEYTDMHAD 360
Query: 404 YTGQGFDQLLDVI 416
YTG+GFDQL+DVI
Sbjct: 361 YTGKGFDQLMDVI 373
>B9GCZ3_ORYSJ (tr|B9GCZ3) Putative uncharacterized protein OS=Oryza sativa subsp.
japonica GN=OsJ_35972 PE=4 SV=1
Length = 521
Score = 573 bits (1476), Expect = e-161, Method: Compositional matrix adjust.
Identities = 265/373 (71%), Positives = 313/373 (83%), Gaps = 4/373 (1%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRK 105
+++NG N +S+ +R+YQVVV+ATRDMGIGK+G LPW+LP DLKFFKD+T+TTSD +K
Sbjct: 3 TNVNNG--NSESNLKRSYQVVVSATRDMGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKK 60
Query: 106 NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPY 165
NAV+MGRKTWESIPL+ RPLPGRLNV+LTRSGSFD ATAENVVICG PY
Sbjct: 61 NAVVMGRKTWESIPLKFRPLPGRLNVILTRSGSFDFATAENVVICGSLDSALQLLATTPY 120
Query: 166 CLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPI 225
CL++EK FIIGGG+ILR+SLNAP C+AIH+T+IE+SI+CDTFIP ID S+F PWYSSFP+
Sbjct: 121 CLTVEKTFIIGGGEILRQSLNAPACEAIHLTDIESSIECDTFIPPIDLSMFHPWYSSFPV 180
Query: 226 VENNVRYCFATYVRVRVSAVESHGQDNG--LSSDNSYIKFEVKKFSFLPKMVFERHEEFL 283
VEN +++ F ++VRV S E++ +D+ +KFE++ FSFLPKM+FERHEE+
Sbjct: 181 VENGIKHSFISFVRVTKSIAEANDSSGKELTGNDSKKVKFEIENFSFLPKMIFERHEEYQ 240
Query: 284 YLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFI 343
YL LVQDII +G K+DRTGTGT+SKFGCQMRFNLRR FPLLTTK+VFWRGV+EELLWFI
Sbjct: 241 YLNLVQDIIRNGAKKNDRTGTGTVSKFGCQMRFNLRRNFPLLTTKRVFWRGVLEELLWFI 300
Query: 344 SGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHAD 403
SGSTN KVLQEKGIHIWDGNASR YLD IGL REEGDLGPVYGFQWRHFGA YTDMHAD
Sbjct: 301 SGSTNAKVLQEKGIHIWDGNASRQYLDSIGLTQREEGDLGPVYGFQWRHFGAEYTDMHAD 360
Query: 404 YTGQGFDQLLDVI 416
Y G+GFDQL+DVI
Sbjct: 361 YVGKGFDQLMDVI 373
>B9R7Y4_RICCO (tr|B9R7Y4) Bifunctional dihydrofolate reductase-thymidylate
synthase, putative OS=Ricinus communis GN=RCOM_1595270
PE=4 SV=1
Length = 591
Score = 570 bits (1470), Expect = e-161, Method: Compositional matrix adjust.
Identities = 284/432 (65%), Positives = 331/432 (76%), Gaps = 20/432 (4%)
Query: 1 FDFLIALLFQVLKNFCKS--W-----------VYTVSSEVPSSNFCLAFFSNMAGDSKAS 47
DF A+L +VL + CK+ W + VS E P S M+GD
Sbjct: 13 LDFDAAMLTRVLLSSCKNSFWNSSYLSVAVTRLQIVSCESPKWR-SYRRLSVMSGDVSIG 71
Query: 48 LSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNA 107
+ G AN+ D R YQVVVAATRDMGIGK+GKLPWRLPSDLKFFK++TLTTS G++NA
Sbjct: 72 IPRGNANMHLDRNRRYQVVVAATRDMGIGKDGKLPWRLPSDLKFFKELTLTTSSPGKRNA 131
Query: 108 VIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCL 167
V+MGRKTWESIPL++RPLPGRLN+VLT SG DI TAE+V+ CG PY
Sbjct: 132 VVMGRKTWESIPLKYRPLPGRLNIVLTCSGGCDITTAEDVLTCGSIPSALELLAEAPYSF 191
Query: 168 SIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVE 227
IEKVF IGGGQILR+++NAPGCDAIHITEIETSI+CDTFIP ID S+F PWYSS PIVE
Sbjct: 192 LIEKVFFIGGGQILRKTINAPGCDAIHITEIETSIECDTFIPVIDFSLFHPWYSSLPIVE 251
Query: 228 NNVRYCFATYVRVRVS---AVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLY 284
NNVRY FATYVRV+ S + NG S N+ FEVK F+FLP +++++H+E++Y
Sbjct: 252 NNVRYSFATYVRVKNSENGTLSKSASANGNLSSNT---FEVKNFTFLPSIIYKKHDEYMY 308
Query: 285 LRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFIS 344
LRL + IIS+G LKDDRTGTGTLSKFG QM++NLR++FPLLTTK+VFW GVVEELLWFIS
Sbjct: 309 LRLAEQIISNGTLKDDRTGTGTLSKFGGQMQYNLRKSFPLLTTKRVFWMGVVEELLWFIS 368
Query: 345 GSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADY 404
GSTN KVLQEKGIHIWDGNASRDYLD IGLKD EE DLGP+YGFQWR+FGARYTDMHADY
Sbjct: 369 GSTNAKVLQEKGIHIWDGNASRDYLDSIGLKDIEESDLGPIYGFQWRYFGARYTDMHADY 428
Query: 405 TGQGFDQLLDVI 416
+GQGFDQL+DVI
Sbjct: 429 SGQGFDQLVDVI 440
>B6UD82_MAIZE (tr|B6UD82) Bifunctional dihydrofolate reductase-thymidylate
synthase OS=Zea mays PE=2 SV=1
Length = 523
Score = 566 bits (1458), Expect = e-159, Method: Compositional matrix adjust.
Identities = 267/369 (72%), Positives = 306/369 (82%), Gaps = 4/369 (1%)
Query: 51 GTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIM 110
+ + QS P+R YQVVVAAT DMGIGK G LPW+L DLKFFK++TLTT+D +KNAVIM
Sbjct: 8 ASGDSQSGPQRNYQVVVAATCDMGIGKGGVLPWKLLGDLKFFKELTLTTTDPAKKNAVIM 67
Query: 111 GRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIE 170
GRKTWESIP++ RPLPGRLNV+LTRSGSFD AT ENVVICG PYCLSIE
Sbjct: 68 GRKTWESIPVKSRPLPGRLNVILTRSGSFDFATVENVVICGSMKSALELLASTPYCLSIE 127
Query: 171 KVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNV 230
KVF+IGGGQ+LR+ LN P C+AIH+T+I++SI+CDTFIP +D SVFQPWYSSFP+VE+N+
Sbjct: 128 KVFVIGGGQVLRDYLNGPACEAIHLTDIQSSIECDTFIPPVDFSVFQPWYSSFPVVESNI 187
Query: 231 RYCFATYVRVRVSAVESHGQDNG---LSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRL 287
R+ F T+VRVR S E+H + NG D KFE++ FSFLPKMV +RHEE+ YL L
Sbjct: 188 RHSFVTFVRVRKSVAETH-ESNGKELTEIDTKNDKFEIENFSFLPKMVHDRHEEYQYLNL 246
Query: 288 VQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGST 347
V+DII G K+DRTGTGTLSKFGCQMRFNLR+ FPLLTTK+VFWRGVVEELLWFISGST
Sbjct: 247 VEDIIRFGAQKNDRTGTGTLSKFGCQMRFNLRKIFPLLTTKRVFWRGVVEELLWFISGST 306
Query: 348 NCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQ 407
N KVLQEKGIHIWDGNASR+YLD IGL REEGDLGPVYGFQWRHFGA YTDMHADYTG+
Sbjct: 307 NAKVLQEKGIHIWDGNASREYLDRIGLAHREEGDLGPVYGFQWRHFGAEYTDMHADYTGK 366
Query: 408 GFDQLLDVI 416
GFDQL+DVI
Sbjct: 367 GFDQLMDVI 375
>D7MEC7_ARALY (tr|D7MEC7) Predicted protein OS=Arabidopsis lyrata subsp. lyrata
GN=ARALYDRAFT_656540 PE=4 SV=1
Length = 565
Score = 563 bits (1452), Expect = e-158, Method: Compositional matrix adjust.
Identities = 281/415 (67%), Positives = 325/415 (78%), Gaps = 13/415 (3%)
Query: 3 FLIALLFQVLKNFCKSWVYTVSSEVPSSNFCLAFFSNMAGDSKASLSNGTANIQSDPRRT 62
F ALL + FCK S PSS LA ++ + A+ NG + S P+ T
Sbjct: 15 FKSALLPLSQRWFCKF------SPKPSS---LANIFKVSVSTMANTLNGNVIMPSKPQST 65
Query: 63 YQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEH 122
YQVVVAAT++MGIGK+GKLPW LP+DLKFFKD+TLTTSDS +KNAV+MGRKTWESIP ++
Sbjct: 66 YQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDLTLTTSDSAKKNAVVMGRKTWESIPTKY 125
Query: 123 RPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILR 182
RPL GRLNVVLTRS DIA ENVV C P+ LSIEKVF+IGGG ILR
Sbjct: 126 RPLSGRLNVVLTRSSGVDIANTENVVTCSSIDSALDLLAAPPFSLSIEKVFVIGGGDILR 185
Query: 183 ESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRV 242
E+LN P C+AIH+TEI+TSIDCDTFIP +D+S +QPW SSFPI EN +R+ F TYVRV+
Sbjct: 186 EALNGPSCEAIHLTEIDTSIDCDTFIPAVDTSAYQPWCSSFPICENGLRFSFTTYVRVKS 245
Query: 243 SAVESHGQDNGLSSDNSYIKFEVKKFS-FLPKMVFERHEEFLYLRLVQDIISDGNLKDDR 301
S S + + +S + ++ + KKFS FLPKM+F+RHEEFLYL LV++IIS+GNLK DR
Sbjct: 246 S---SACESSDVSDGSKVLQVDWKKFSSFLPKMIFDRHEEFLYLNLVKEIISNGNLKGDR 302
Query: 302 TGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWD 361
TGTGTLSKFGCQM+FNLRR FPLLTTK+VFWRGVVEELLWFISGSTN KVLQEKGI IWD
Sbjct: 303 TGTGTLSKFGCQMKFNLRRNFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGIRIWD 362
Query: 362 GNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GNASR YLDGIGL +REEGDLGPVYGFQWRHFGA+YTDMHADYTGQGFDQLLDVI
Sbjct: 363 GNASRAYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDVI 417
>B8BPG2_ORYSI (tr|B8BPG2) Putative uncharacterized protein OS=Oryza sativa subsp.
indica GN=OsI_38205 PE=4 SV=1
Length = 494
Score = 546 bits (1408), Expect = e-153, Method: Compositional matrix adjust.
Identities = 251/346 (72%), Positives = 291/346 (84%), Gaps = 2/346 (0%)
Query: 73 MGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVV 132
MGIGK+G LPW+LP DLKFFKD+T+TTSD +KNAV+MGRKTWESIPL+ RPLPGRLNV+
Sbjct: 1 MGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKKNAVVMGRKTWESIPLKFRPLPGRLNVI 60
Query: 133 LTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA 192
LTRSGSFD ATAENVVICG PYCL++EK FIIGGG+ILR+SLNAP C+A
Sbjct: 61 LTRSGSFDFATAENVVICGSLDSALQLLATTPYCLTVEKTFIIGGGEILRQSLNAPACEA 120
Query: 193 IHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDN 252
IH+T+IE+SI+CDTFIP ID S+F PWYSSFP+VEN +++ F ++VRV S E++
Sbjct: 121 IHLTDIESSIECDTFIPPIDLSMFHPWYSSFPVVENGIKHSFISFVRVTKSIAEANDSSG 180
Query: 253 G--LSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKF 310
+D+ +KFE++ FSFLPKM+FERHEE+ YL LVQDII +G K+DRTGTGT+SKF
Sbjct: 181 KELTGNDSKKVKFEIENFSFLPKMIFERHEEYQYLNLVQDIIRNGAKKNDRTGTGTVSKF 240
Query: 311 GCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLD 370
GCQMRFNLRR FPLLTTK+VFWRGV+EELLWFISGSTN KVLQEKGIHIWDGNASR YLD
Sbjct: 241 GCQMRFNLRRNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEKGIHIWDGNASRQYLD 300
Query: 371 GIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
IGL REEGDLGPVYGFQWRHFGA YTDMHADY G+GFDQL+DVI
Sbjct: 301 SIGLTQREEGDLGPVYGFQWRHFGAEYTDMHADYVGKGFDQLMDVI 346
>B7FA29_ORYSJ (tr|B7FA29) cDNA, clone: J100037K11, full insert sequence OS=Oryza
sativa subsp. japonica PE=2 SV=1
Length = 494
Score = 546 bits (1408), Expect = e-153, Method: Compositional matrix adjust.
Identities = 251/346 (72%), Positives = 291/346 (84%), Gaps = 2/346 (0%)
Query: 73 MGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVV 132
MGIGK+G LPW+LP DLKFFKD+T+TTSD +KNAV+MGRKTWESIPL+ RPLPGRLNV+
Sbjct: 1 MGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKKNAVVMGRKTWESIPLKFRPLPGRLNVI 60
Query: 133 LTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA 192
LTRSGSFD ATAENVVICG PYCL++EK FIIGGG+ILR+SLNAP C+A
Sbjct: 61 LTRSGSFDFATAENVVICGSLDSALQLLATTPYCLTVEKTFIIGGGEILRQSLNAPACEA 120
Query: 193 IHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDN 252
IH+T+IE+SI+CDTFIP ID S+F PWYSSFP+VEN +++ F ++VRV S E++
Sbjct: 121 IHLTDIESSIECDTFIPPIDLSMFHPWYSSFPVVENGIKHSFISFVRVTKSIAEANDSSG 180
Query: 253 G--LSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKF 310
+D+ +KFE++ FSFLPKM+FERHEE+ YL LVQDII +G K+DRTGTGT+SKF
Sbjct: 181 KELTGNDSKKVKFEIENFSFLPKMIFERHEEYQYLNLVQDIIRNGAKKNDRTGTGTVSKF 240
Query: 311 GCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLD 370
GCQMRFNLRR FPLLTTK+VFWRGV+EELLWFISGSTN KVLQEKGIHIWDGNASR YLD
Sbjct: 241 GCQMRFNLRRNFPLLTTKRVFWRGVLEELLWFISGSTNAKVLQEKGIHIWDGNASRQYLD 300
Query: 371 GIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
IGL REEGDLGPVYGFQWRHFGA YTDMHADY G+GFDQL+DVI
Sbjct: 301 SIGLTQREEGDLGPVYGFQWRHFGAEYTDMHADYVGKGFDQLMDVI 346
>B8BKI9_ORYSI (tr|B8BKI9) Putative uncharacterized protein OS=Oryza sativa subsp.
indica GN=OsI_36122 PE=4 SV=1
Length = 404
Score = 532 bits (1370), Expect = e-149, Method: Compositional matrix adjust.
Identities = 251/359 (69%), Positives = 293/359 (81%), Gaps = 6/359 (1%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRK 105
+LSN + Q+ P+R YQVVVAATRDMGIGK+G LPW+L DLKFFK++T+TT+D +K
Sbjct: 3 TTLSNDVS--QNGPQRNYQVVVAATRDMGIGKDGVLPWKLLGDLKFFKELTVTTADPVKK 60
Query: 106 NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPY 165
NAVIMGRKTWES+PL+ RPLPGRLN++LTRSGSF+ AT ENVVICG PY
Sbjct: 61 NAVIMGRKTWESLPLKARPLPGRLNIILTRSGSFEFATVENVVICGSMNSALELLSSTPY 120
Query: 166 CLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPI 225
CLSIEKVF+IGGGQ+LRESLN P C+A+H+T+I++SI+CDTFIP ID SVFQPWYSS P+
Sbjct: 121 CLSIEKVFVIGGGQVLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLSVFQPWYSSLPV 180
Query: 226 VENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYI---KFEVKKFSFLPKMVFERHEEF 282
VE+N+R+ F TYVRVR + E+H NG S N I KFE + FSFLPK++F+RHEE+
Sbjct: 181 VESNIRHSFVTYVRVRKTMAETH-DSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEY 239
Query: 283 LYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWF 342
YL LV+DII G K+DRTGTGTLSKFGCQMRFNLR +FPLLTTKKVFWRGVVEELLWF
Sbjct: 240 HYLNLVEDIIRSGAQKNDRTGTGTLSKFGCQMRFNLRNSFPLLTTKKVFWRGVVEELLWF 299
Query: 343 ISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMH 401
ISGST+ KVLQEKGIHIWDGNASR+YLD +GL REEGDLGPVYGFQWRHFGA H
Sbjct: 300 ISGSTSAKVLQEKGIHIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAESVAKH 358
>B9HRK6_POPTR (tr|B9HRK6) Dihydrofolate reductase-thymidylate synthase OS=Populus
trichocarpa GN=DHFR-TS-2 PE=4 SV=1
Length = 414
Score = 469 bits (1207), Expect = e-130, Method: Compositional matrix adjust.
Identities = 222/255 (87%), Positives = 234/255 (91%), Gaps = 2/255 (0%)
Query: 164 PYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSF 223
PY LSIEKVF+IGGGQILRESLNAPGCDAIHITEIET DCDTFIP ID+SVFQPW SSF
Sbjct: 12 PYFLSIEKVFVIGGGQILRESLNAPGCDAIHITEIETDFDCDTFIPAIDTSVFQPWCSSF 71
Query: 224 PIVENNVRYCFATYVRVRVSAVESHGQDNGLSSD--NSYIKFEVKKFSFLPKMVFERHEE 281
P +EN++RYCF TYVRVR SA+ESH Q NG+SSD + KFEVKKFSFLPKMVFERHEE
Sbjct: 72 PKMENDIRYCFTTYVRVRSSAIESHSQKNGVSSDGNSENSKFEVKKFSFLPKMVFERHEE 131
Query: 282 FLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLW 341
+LYLRLVQDII+DGNLKD R GTGTLSKFGCQMRFNLR+TFP LTTKKVFWRGVVEELLW
Sbjct: 132 YLYLRLVQDIITDGNLKDGRAGTGTLSKFGCQMRFNLRKTFPFLTTKKVFWRGVVEELLW 191
Query: 342 FISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMH 401
FISGSTN KVLQEKGIHIWDGNASRDYLD +GLKDREEGDLGP YGFQWRHFGARYTDMH
Sbjct: 192 FISGSTNAKVLQEKGIHIWDGNASRDYLDSVGLKDREEGDLGPFYGFQWRHFGARYTDMH 251
Query: 402 ADYTGQGFDQLLDVI 416
ADYTGQGFDQLLDVI
Sbjct: 252 ADYTGQGFDQLLDVI 266
>A9RXS0_PHYPA (tr|A9RXS0) Predicted protein OS=Physcomitrella patens subsp.
patens GN=PHYPADRAFT_120817 PE=4 SV=1
Length = 520
Score = 423 bits (1088), Expect = e-116, Method: Compositional matrix adjust.
Identities = 210/368 (57%), Positives = 265/368 (72%), Gaps = 18/368 (4%)
Query: 53 ANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGR 112
+ S+ R +Q+VVAATR+ GIGK+G LPW+LP+D+KFFK VT T+ S +KNAVIMGR
Sbjct: 19 SGTHSEKLRGFQIVVAATRERGIGKQGHLPWKLPTDMKFFKTVTSVTTSSSKKNAVIMGR 78
Query: 113 KTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKV 172
TWESIP + RPLPGRLNV+LTRSG +T VV+ Y +E V
Sbjct: 79 HTWESIPEKFRPLPGRLNVILTRSGI--KSTPAGVVVSESLQSALALIATPSYSSHVESV 136
Query: 173 FIIGGGQILR----ESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVEN 228
F+IGGGQ++ E++ +P C+ IH+TE+E ++CDT++P +D+ +F+ W +S PIVEN
Sbjct: 137 FVIGGGQLVSTVCSEAMASPLCEVIHLTEVEGDVECDTYMPAVDTDIFRIWSASIPIVEN 196
Query: 229 NVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLV 288
+R F TYVR +++ DNG ++ LPK + E H+E+ YL L+
Sbjct: 197 GLRISFLTYVRGSLTSSIKQ-TDNGETT-----------VGLLPKYLLEAHDEYQYLNLI 244
Query: 289 QDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTN 348
DII G +K DRTGTGT+SKFGCQMRFNLR++FPLLTTK+VFWRGVVEELLWFISGSTN
Sbjct: 245 DDIIKTGAVKGDRTGTGTISKFGCQMRFNLRKSFPLLTTKRVFWRGVVEELLWFISGSTN 304
Query: 349 CKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQG 408
KVL +KG+ IWDGN SR+YLD GL +REEGDLGPVYGFQWRHFGA+Y DMHADYTGQG
Sbjct: 305 AKVLHDKGVKIWDGNGSREYLDKQGLTEREEGDLGPVYGFQWRHFGAKYVDMHADYTGQG 364
Query: 409 FDQLLDVI 416
+DQL DVI
Sbjct: 365 YDQLKDVI 372
>Q9SIK4_ARATH (tr|Q9SIK4) Putative dihydrofolate reductase-thymidylate synthase
OS=Arabidopsis thaliana GN=At2g21550 PE=2 SV=1
Length = 492
Score = 408 bits (1048), Expect = e-112, Method: Compositional matrix adjust.
Identities = 203/378 (53%), Positives = 261/378 (69%), Gaps = 22/378 (5%)
Query: 40 MAGDSKASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTT 99
MA + +NG + + RR+YQVV+AATRDMG+G + KLPW LPS+ +FF+DVT T
Sbjct: 1 MASTGETICNNGQSAVSVTRRRSYQVVIAATRDMGLGMDMKLPWDLPSEYQFFQDVTTRT 60
Query: 100 SDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXX 159
SD ++NA IMGRK+WES PLE RPLPGRLN+VLT+S +IA ENV++
Sbjct: 61 SDPTKRNATIMGRKSWESTPLEIRPLPGRLNIVLTKSSCHNIAIDENVLVSSSMESALEL 120
Query: 160 XXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPW 219
PY LSIEKVF+IGGG++LR +NA CDAIH+TEI+ S+ CD F P++D+S+++PW
Sbjct: 121 LATEPYSLSIEKVFVIGGGELLRNYMNASICDAIHLTEIDISVPCDAFAPRVDTSLYRPW 180
Query: 220 YSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERH 279
YSSFP+VEN +RY F TYVR R A+ G+ ++ ++K++SFLPKMVFERH
Sbjct: 181 YSSFPVVENGIRYSFNTYVR-RKDAIVGSGEKKSVAES------DLKEYSFLPKMVFERH 233
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
EEF YL LVQ+IIS G++ D+ TLSKFGCQMRFNLR+TFPLLTTKK+FW GVVEE+
Sbjct: 234 EEFGYLNLVQNIISSGDMNDN----STLSKFGCQMRFNLRKTFPLLTTKKIFWLGVVEEI 289
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREE-GDLGPVYGFQWRHFGARYT 398
L ISGS N K E G HIWD + +++YLD G+ EE GD ++G W+H AR+
Sbjct: 290 LQLISGSNNPK---ENGSHIWDTDEAKEYLDSFGVNATEEDGDNPFLHGLHWKHCDARFV 346
Query: 399 DMHADYTGQGFDQLLDVI 416
Q F QL DVI
Sbjct: 347 I-------QEFSQLSDVI 357
>D7LBE8_ARALY (tr|D7LBE8) Predicted protein OS=Arabidopsis lyrata subsp. lyrata
GN=ARALYDRAFT_667353 PE=4 SV=1
Length = 490
Score = 398 bits (1023), Expect = e-109, Method: Compositional matrix adjust.
Identities = 205/373 (54%), Positives = 258/373 (69%), Gaps = 23/373 (6%)
Query: 45 KASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGR 104
+A NG + + S RR+YQVV+AATRDMG+G + KLPW LP+D +FF DVT T+D R
Sbjct: 5 EAMFINGQSTV-SVTRRSYQVVIAATRDMGLGMDMKLPWDLPTDSQFFHDVTTRTTDPTR 63
Query: 105 KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXP 164
+NA IMGRK+WES PLE RPLPGRLN+VLT+S +IA ENV++C P
Sbjct: 64 RNATIMGRKSWESTPLEIRPLPGRLNIVLTKSSCHNIAIDENVLVCDSMESALELLATEP 123
Query: 165 YCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFP 224
Y LSIEKVF+IGGG++LR +NAP CDAIH+TEI+ S+ CD F P++D+S++ PWYSSFP
Sbjct: 124 YSLSIEKVFVIGGGELLRNYMNAPSCDAIHLTEIDISVPCDAFAPRVDTSLYHPWYSSFP 183
Query: 225 IVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLY 284
IVEN +RY F TYVR + + V S + + SD K++SFLPKMVFERH+EF Y
Sbjct: 184 IVENGIRYSFNTYVRRKDAVVGSGEKKSAAGSD-------FKEYSFLPKMVFERHDEFGY 236
Query: 285 LRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFIS 344
L L+Q+IIS G++ D+ TL+KFGCQMRFNLR+TFPLLTTKKVFW GVVEE+L IS
Sbjct: 237 LNLIQNIISSGDMNDN----NTLTKFGCQMRFNLRKTFPLLTTKKVFWLGVVEEILQLIS 292
Query: 345 GSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREE-GDLGPVYGFQWRHFGARYTDMHAD 403
GS N EKG +IWD + + +YL+ G+ EE GD +YG QW+H AR
Sbjct: 293 GSINP---MEKGSNIWDSDEANEYLNSFGVNATEEDGDHQHLYGLQWKHTDAR------- 342
Query: 404 YTGQGFDQLLDVI 416
Q F QL DVI
Sbjct: 343 LIVQKFSQLSDVI 355
>A4RXM1_OSTLU (tr|A4RXM1) Predicted protein OS=Ostreococcus lucimarinus (strain
CCE9901) GN=OSTLU_49676 PE=4 SV=1
Length = 499
Score = 384 bits (987), Expect = e-105, Method: Compositional matrix adjust.
Identities = 192/362 (53%), Positives = 238/362 (65%), Gaps = 24/362 (6%)
Query: 63 YQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEH 122
+QVVVAATR+ GIG+E LPWRL D+ +FK +T T D NAV+MGRKTWESIP +
Sbjct: 6 FQVVVAATREGGIGRENALPWRLAGDMGYFKKITSETRDGDAMNAVVMGRKTWESIPGKF 65
Query: 123 RPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLS--------IEKVFI 174
RPLPGRLN+VL+RSG A EN LS IEK F+
Sbjct: 66 RPLPGRLNIVLSRSGGLAEANDENNNGAETLPEGVLVRKSIDDALSAISSSEKRIEKTFV 125
Query: 175 IGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCF 234
IGG QI E+L + C+A+H+TE+E +CD FIPKID++ F+ + S P++E R+ F
Sbjct: 126 IGGAQIYEEALQSEKCEAVHLTEVEGEFECDAFIPKIDATKFKLYGQSKPMIEKGTRFQF 185
Query: 235 ATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISD 294
TYV ++D KF K LP +HEE+ YL ++++II
Sbjct: 186 LTYV----------------TADAESGKFRPKADEVLPAGCSIKHEEYQYLEMIREIIDQ 229
Query: 295 GNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQE 354
G +K DRTGTGT+S FG QMRF+LRR+FPLLTTK+VFWRGV EELLWF++G TN L E
Sbjct: 230 GAVKGDRTGTGTISTFGNQMRFDLRRSFPLLTTKRVFWRGVAEELLWFVAGETNANKLAE 289
Query: 355 KGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLD 414
K I+IWDGN SR+YLD IGL +RE GDLGPVYGFQWRHFGA YT+MHADYTG+G DQL +
Sbjct: 290 KKINIWDGNGSREYLDSIGLTEREVGDLGPVYGFQWRHFGAEYTNMHADYTGKGVDQLAE 349
Query: 415 VI 416
VI
Sbjct: 350 VI 351
>Q01FK1_OSTTA (tr|Q01FK1) Bifunctional dihydrofolate reductase-thymidylate
synthase 2 / DHFR-TS (ISS) OS=Ostreococcus tauri
GN=Ot01g05780 PE=4 SV=1
Length = 751
Score = 384 bits (985), Expect = e-104, Method: Compositional matrix adjust.
Identities = 194/364 (53%), Positives = 235/364 (64%), Gaps = 24/364 (6%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPL 120
R +QVVVAAT D GIGK+ LPW+L D+ FK +T T D+ NAV+MGRKTWESIP
Sbjct: 256 RAFQVVVAATVDGGIGKDNGLPWKLTKDMGHFKKLTSETRDANAVNAVVMGRKTWESIPA 315
Query: 121 EHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLS--------IEKV 172
+ RPLPGRLNVVL+RSG A EN LS +EK
Sbjct: 316 KFRPLPGRLNVVLSRSGVLAEANDENNNGAETLPEGVLVRKTIDDALSAISSSEKRVEKT 375
Query: 173 FIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRY 232
F+IGG QI E+L + C+A+H+TE+E +CD FIPKID+ F+ + S PI EN RY
Sbjct: 376 FVIGGAQIYEEALKSERCEAVHLTEVEGDFECDVFIPKIDADKFKLYGQSKPITENGARY 435
Query: 233 CFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDII 292
F TYV + D+ KF LP +HEE YL ++++II
Sbjct: 436 QFLTYV----------------TKDSESGKFRPIAGELLPAGCDVKHEEHQYLDMIREII 479
Query: 293 SDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVL 352
G +K DRTGTGT+S FG QMRF+LRR+FPLLTTK+VFWRGV EELLWF++G TN L
Sbjct: 480 DQGAVKGDRTGTGTISTFGNQMRFDLRRSFPLLTTKRVFWRGVAEELLWFVAGETNANKL 539
Query: 353 QEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQL 412
EK I+IWDGN SR+YLD IGL +RE GDLGPVYGFQWRHFGA YT+MHADYTG+G DQL
Sbjct: 540 AEKKINIWDGNGSREYLDSIGLTEREVGDLGPVYGFQWRHFGAEYTNMHADYTGKGVDQL 599
Query: 413 LDVI 416
+VI
Sbjct: 600 AEVI 603
>C1MMA6_MICPS (tr|C1MMA6) Bifunctional dihydrofolate reductase-thymidylate
synthase OS=Micromonas pusilla CCMP1545 GN=DHFR-TS PE=4
SV=1
Length = 524
Score = 377 bits (969), Expect = e-102, Method: Compositional matrix adjust.
Identities = 192/383 (50%), Positives = 246/383 (64%), Gaps = 43/383 (11%)
Query: 61 RTYQVVVAATR-DMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIP 119
R +QVVVAAT+ DMGIG +G LPWRLP D+ +FK VT T ++ G++NAVIMGRKTWESIP
Sbjct: 10 RPFQVVVAATKGDMGIGLDGALPWRLPKDMAYFKSVTATVAEPGKRNAVIMGRKTWESIP 69
Query: 120 LEHRPLPGRLNVVLTRSGSFDIAT-AEN---------------VVICGXXXXXXXXXXXX 163
+ RPLPGRLNVVL++SG+ +T +EN V++
Sbjct: 70 AKFRPLPGRLNVVLSKSGALVESTGSENAAPANGTPSNVLPPSVLLQPSLEAALATLGAG 129
Query: 164 PYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSID------CDTFIPKIDSSVFQ 217
+ ++EK+F++GG Q+ E++ +P C A+HITE+ D CDT +P +D F+
Sbjct: 130 EHAENVEKIFVVGGAQVYAEAMASPACQAVHITEVTPPKDTPDAFKCDTHMPPVDMEKFK 189
Query: 218 PWYSSFPIVENN-VRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVF 276
+ S+ P+ E + F +YV + D + KF + LP
Sbjct: 190 LYASAPPVNEKEGAKIQFLSYV----------------AKDAATGKFRIPGSVSLPPGAV 233
Query: 277 E---RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWR 333
RHEE YL L++DII GN+K DRTGTGT+SKFG MRF+LRR+FPLLTTK+VFWR
Sbjct: 234 ANGVRHEELQYLDLIRDIIESGNVKGDRTGTGTISKFGTSMRFDLRRSFPLLTTKRVFWR 293
Query: 334 GVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHF 393
GV EELLWF+ G TN K LQ+K IHIWDGN SR+YLD +GL REE DLGPVYGFQWRHF
Sbjct: 294 GVAEELLWFVGGRTNAKELQDKDIHIWDGNGSREYLDSVGLSHREEQDLGPVYGFQWRHF 353
Query: 394 GARYTDMHADYTGQGFDQLLDVI 416
GA YTDMHA+Y G+G DQL +VI
Sbjct: 354 GAEYTDMHANYDGKGVDQLAEVI 376
>C1E6F7_9CHLO (tr|C1E6F7) Bifunctional dihydrofolate reductase-thymidylate
synthase OS=Micromonas sp. RCC299 GN=DHFR-TS PE=4 SV=1
Length = 523
Score = 370 bits (951), Expect = e-100, Method: Compositional matrix adjust.
Identities = 191/383 (49%), Positives = 241/383 (62%), Gaps = 43/383 (11%)
Query: 61 RTYQVVVAATR-DMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIP 119
R +QVVVAAT+ +MGIG +G LPW LP D+ +FK VT ++ G KNAV+MGRKTWESIP
Sbjct: 9 RPFQVVVAATKGEMGIGYQGGLPWNLPKDMAYFKAVTSQVNEPGTKNAVVMGRKTWESIP 68
Query: 120 LEHRPLPGRLNVVLTRSGSFDIATAEN----------------VVICGXXXXXXXXXXXX 163
+ RPLPGR+NVVL+R + A +EN V +
Sbjct: 69 AKFRPLPGRVNVVLSRGHTLVEAGSENSAPVNGGGKPEVLPEGVFLRPSLEAALELLSAP 128
Query: 164 PYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSID------CDTFIPKIDSSVFQ 217
+ +EKVF+IGG Q+ E++ +P C A+H+TE+ D CD F+P+ID + F+
Sbjct: 129 EHEAGVEKVFVIGGAQVYAEAMASPHCQALHLTEVTPPADEPEKYKCDAFLPQIDPAKFK 188
Query: 218 PWYSSFPIVENN-VRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVF 276
+ S+ P+ E + F TY V D KF LP
Sbjct: 189 LYASAKPLREKDGATIQFLTYFGV----------------DPGTGKFRSPGSKVLPAGAV 232
Query: 277 E---RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWR 333
RHEE YL L+++I+ +GN+K DRTGTGT+SKFGCQMRF+LRR+FPLLTTK+VFWR
Sbjct: 233 AKGVRHEEMQYLDLIKEIMEEGNVKGDRTGTGTISKFGCQMRFDLRRSFPLLTTKRVFWR 292
Query: 334 GVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHF 393
GV EEL+WF+ G T+ K LQ+K IHIWDGN SR+YLD +GL REEGDLGPVYGFQWRHF
Sbjct: 293 GVAEELIWFVKGCTSAKELQDKDIHIWDGNGSREYLDSVGLGHREEGDLGPVYGFQWRHF 352
Query: 394 GARYTDMHADYTGQGFDQLLDVI 416
GA Y DMHADYTGQG DQL +VI
Sbjct: 353 GAEYKDMHADYTGQGVDQLAEVI 375
>A8JD96_CHLRE (tr|A8JD96) Predicted protein OS=Chlamydomonas reinhardtii
GN=CHLREDRAFT_139742 PE=4 SV=1
Length = 478
Score = 363 bits (931), Expect = 2e-98, Method: Compositional matrix adjust.
Identities = 181/358 (50%), Positives = 231/358 (64%), Gaps = 33/358 (9%)
Query: 60 RRTYQVVVAATRDMGIGKEGKLP-WRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESI 118
R+ +Q+V+AAT +GIGK GKLP W+LP D+ +FK++T T D NAVIMGRKTWESI
Sbjct: 5 RKGFQLVIAATPSLGIGKNGKLPDWQLPGDMAYFKELTSRTRDGAHTNAVIMGRKTWESI 64
Query: 119 PLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGG 178
P + RPL GRLN+VL+RS + D E+ + +E VFIIGGG
Sbjct: 65 PAKFRPLKGRLNIVLSRSFADDADLLESALSLLEHKELKG---------GVEGVFIIGGG 115
Query: 179 QILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYV 238
Q+ E+L P C A+H+T++E +CDTF+P +D +V+ W SS P+ ENN RY F Y
Sbjct: 116 QVYAEALAHPNCTAVHLTQVEKEYECDTFLPALDPAVWGVWSSSEPVTENNTRYSFVCYT 175
Query: 239 RVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLK 298
R LP + RH+E YL LV+++I+ G +
Sbjct: 176 RRGTEQAPE-----------------------LPPCMASRHDEQQYLELVRELITSGVFR 212
Query: 299 DDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIH 358
DRTGTGT S+FG R+NLR TFPLLT+K+VFW+GV EELLWFISG+TN +L++K IH
Sbjct: 213 PDRTGTGTYSRFGRTSRYNLRHTFPLLTSKRVFWKGVAEELLWFISGATNANLLRDKNIH 272
Query: 359 IWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
IWDGN+SR++LDG GL RE GDLGPVYGFQWRHFGA Y DMH DYTG+G DQL +I
Sbjct: 273 IWDGNSSREFLDGRGLGHREVGDLGPVYGFQWRHFGAEYKDMHTDYTGKGVDQLRYII 330
>D0N806_PHYIN (tr|D0N806) Bifunctional dihydrofolate reductase-thymidylate
synthase 2 OS=Phytophthora infestans T30-4 GN=PITG_06749
PE=4 SV=1
Length = 509
Score = 321 bits (823), Expect = 9e-86, Method: Compositional matrix adjust.
Identities = 173/362 (47%), Positives = 224/362 (61%), Gaps = 29/362 (8%)
Query: 61 RTYQVVVAATRDMG-IGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIP 119
++ +VVVAA G IG +PWRLPSD+K F+ +T + DS ++AVIMGRKTWES+P
Sbjct: 4 QSIRVVVAALETTGGIGLRQHIPWRLPSDMKHFRALTTASPDSSVQHAVIMGRKTWESLP 63
Query: 120 LEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQ 179
+ RP+P R NVVLTR S+ + +++VF+IGGG
Sbjct: 64 AKVRPMPKRYNVVLTRDSSYRNKQEIPDTVGVAASFREALKLVQEQGDKVDQVFVIGGGA 123
Query: 180 ILRESLNAPGCDAIHITEIETSIDCDTFIP--KIDSSVFQPWYSSFPIVENNVRYCFATY 237
+ E+L+ P C +H+T ++ +CD F P +++ + F+ S EN V++ F +
Sbjct: 124 VYAEALSYPSCTKVHLTRVKGQFECDAFFPLEQLEQN-FKVAEESEVKEENGVQFHFVEW 182
Query: 238 VRV--RVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDG 295
R V AVES L DN+ HEE YL L++ I++ G
Sbjct: 183 ERKTGEVKAVES-----ALLVDNT-----------------TPHEEMQYLDLIRKILTQG 220
Query: 296 NLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQE 354
++DRTGTGTLS FG QMRF+LR FPLLTTK+VFWRGV EELLWFISG T+ LQ+
Sbjct: 221 AKREDRTGTGTLSVFGAQMRFSLRNNVFPLLTTKRVFWRGVAEELLWFISGDTSAHTLQQ 280
Query: 355 KGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLD 414
K IHIWDGN SR+YLD GL+ RE GDLGPVYGFQWRHFGA+YTDMHADYTG+G DQL +
Sbjct: 281 KDIHIWDGNGSREYLDSRGLQHREVGDLGPVYGFQWRHFGAKYTDMHADYTGKGVDQLAE 340
Query: 415 VI 416
VI
Sbjct: 341 VI 342
>B9H4E7_POPTR (tr|B9H4E7) Dihydrofolate reductase-thymidylate synthase OS=Populus
trichocarpa GN=DHFR-TS-3b PE=3 SV=1
Length = 283
Score = 312 bits (799), Expect = 5e-83, Method: Compositional matrix adjust.
Identities = 150/231 (64%), Positives = 183/231 (79%), Gaps = 9/231 (3%)
Query: 59 PRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESI 118
P R+YQVVVAATRDMGIGK+GKLPWRLPSDLKFFK+VTL TSD G++NA++MGRKTWESI
Sbjct: 51 PMRSYQVVVAATRDMGIGKDGKLPWRLPSDLKFFKEVTLATSDPGKQNAILMGRKTWESI 110
Query: 119 PLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGG 178
P+++RPLP RLNVVLTRS F+I ENV+ CG PYC SI+KVF+IGGG
Sbjct: 111 PIKYRPLPDRLNVVLTRS--FEIEDEENVITCGSISSALELLAETPYCFSIDKVFVIGGG 168
Query: 179 QILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYV 238
QILRE+LN PGCDAIH+TEIE+S++CDTFIP ID S FQPWYSS P+VEN RY F TYV
Sbjct: 169 QILRETLNGPGCDAIHVTEIESSVECDTFIPSIDFSKFQPWYSSPPLVENGFRYSFVTYV 228
Query: 239 RVRVS-----AVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLY 284
VR S A ++ G+ N + S+++ +FEVK FSFLPKM+FE+ EE+++
Sbjct: 229 HVRNSENETIAGKTGGKCNDVKSNSN--RFEVKDFSFLPKMIFEKGEEYMH 277
>Q22KR8_TETTH (tr|Q22KR8) Bifunctional dihydrofolate reductase-thymidylate
synthase OS=Tetrahymena thermophila SB210
GN=TTHERM_00312120 PE=4 SV=1
Length = 485
Score = 308 bits (789), Expect = 7e-82, Method: Compositional matrix adjust.
Identities = 157/357 (43%), Positives = 219/357 (61%), Gaps = 26/357 (7%)
Query: 61 RTYQVVVAAT-RDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIP 119
R + +V+A T + GIG + LPWRLP++LK FK +T T + G +NAVIMG+ TWE++P
Sbjct: 4 RHFDIVLAQTLKKQGIGYKNSLPWRLPNELKNFKKITTETKNKGLQNAVIMGKNTWEALP 63
Query: 120 LEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQ 179
+ +PL RLN+V++ + + A++ C I+ +IGG +
Sbjct: 64 KKQQPLKDRLNIVISTTMQ-EGQIADHSYACKSLDSALNFLEQQN---QIQDALVIGGAK 119
Query: 180 ILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVR 239
+ +++L+ IH+T + ++CD F+ K F S ENN+ Y F Y
Sbjct: 120 LCQQALSDQRLRQIHLTRVGVEVECDVFMQKDYLKNFDMIEVSETQSENNLNYDFTRYF- 178
Query: 240 VRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKD 299
N K +V F K +++ H+E+ YL L+ +II +G++K
Sbjct: 179 ------------------NKNYKGQVDPSLF--KKMYKPHQEYQYLELIDEIIKNGHVKT 218
Query: 300 DRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHI 359
DRTGTGT+S+FG MRF+L ++FPLLTTK VFWRGVVEEL+WFI GSTN K+L EKG+ I
Sbjct: 219 DRTGTGTISQFGKLMRFDLSKSFPLLTTKNVFWRGVVEELIWFIKGSTNSKILSEKGVKI 278
Query: 360 WDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
WDGN SR++LD +G K+REEGDLGPVYGFQWRHFGA Y DMH +Y G+G DQL D+I
Sbjct: 279 WDGNGSREFLDQLGFKNREEGDLGPVYGFQWRHFGAEYKDMHTNYKGKGVDQLQDLI 335
>B5YMV7_THAPS (tr|B5YMV7) Possible thymidylate synthase (Fragment)
OS=Thalassiosira pseudonana GN=TMS1 PE=4 SV=1
Length = 516
Score = 293 bits (749), Expect = 3e-77, Method: Compositional matrix adjust.
Identities = 164/371 (44%), Positives = 210/371 (56%), Gaps = 26/371 (7%)
Query: 65 VVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEHRP 124
VV AA GIG +GKLPWRLP D+ FK VT T G NAVIMGRKTW+SIP + RP
Sbjct: 1 VVAAAAGSRGIGHQGKLPWRLPGDMNHFKKVTTTPPSPGLTNAVIMGRKTWDSIPSKFRP 60
Query: 125 LPGRLNVVLTRSGSFDI-------------ATAENVVICGXXXXXXXXXXXXPYCLSIEK 171
L GR+NV+L+R + + AE+V++ S
Sbjct: 61 LDGRVNVILSRKSAAGVEGVPMSTDDNNNNNNAEDVLVASSLEEAMQKLDGRANHGS--- 117
Query: 172 VFIIGGGQILRESLNAPGCDAIHITEIE---TSIDCDTFIPKIDSSVFQ--PWYSSFPIV 226
FIIGGG+I + + + + T ++ D F P++ S ++ P+ P
Sbjct: 118 TFIIGGGEIYSQGIKSGLVKRVIYTNVKGLAEDAKLDAFFPELTDSEWECVPFT---PKD 174
Query: 227 ENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLR 286
+V + E H +D ++++ + +P+ EE YL
Sbjct: 175 NAENEETENNHVSKKAKVAEEH-EDAKSGLKYEFLEYIRRDNVDIPEGADVNPEEMQYLE 233
Query: 287 LVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR-RTFPLLTTKKVFWRGVVEELLWFISG 345
+ +DII +G + DRTGTGTLSKFG QMR++LR T PLLTTK+ FWRGV EELLWF+ G
Sbjct: 234 ICRDIIENGVRRGDRTGTGTLSKFGVQMRYSLRDNTLPLLTTKRTFWRGVAEELLWFVKG 293
Query: 346 STNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYT 405
STN L +K IHIWDGN SR++LD GL+ REEGDLGPVYGFQWRHFGA Y DMHADYT
Sbjct: 294 STNANELADKNIHIWDGNGSREFLDSRGLQHREEGDLGPVYGFQWRHFGAEYKDMHADYT 353
Query: 406 GQGFDQLLDVI 416
GQG DQL D I
Sbjct: 354 GQGVDQLADCI 364
>C5LQI2_9ALVE (tr|C5LQI2) Dihydrofolate reductase-thymidylate synthase, putative
OS=Perkinsus marinus ATCC 50983 GN=Pmar_PMAR025126 PE=4
SV=1
Length = 492
Score = 285 bits (730), Expect = 5e-75, Method: Compositional matrix adjust.
Identities = 163/357 (45%), Positives = 212/357 (59%), Gaps = 26/357 (7%)
Query: 65 VVVAATRDMGIGKEGKLPWR-LPSDLKFFKDVTLT-TSDSGRKNAVIMGRKTWESIPLEH 122
V+VA T GIGK+G+LPW+ LP D+K FK +T + KN IMGRKTWESIP
Sbjct: 8 VIVAHTCKWGIGKDGQLPWKSLPEDMKRFKKITTGGHCNDNVKNVCIMGRKTWESIPERF 67
Query: 123 RPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILR 182
RPL R+NVV++ + S V IC + I ++F+IGG ++
Sbjct: 68 RPLRDRINVVISSTTS-PTDYPPGVRICPSLLDSLASLQQGE--VEIGEIFVIGGASLIT 124
Query: 183 ESLNAPGCDAIHITEIETSI-DCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVR 241
E++ P C ++ T + T +CD F+ KID +++P S +++ Y F Y R
Sbjct: 125 EAMQLPQCRTLYTTRVGTDPWECDVFMEKIDEKIWEPIAVSRTFRHSDIPYDFVDYKR-- 182
Query: 242 VSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDR 301
G D K E+ P+ F+ H E+ YLRL+++II +G DDR
Sbjct: 183 -----REGSD----------KTELSLAERCPRGKFQ-HGEYEYLRLIEEIIENGEDADDR 226
Query: 302 TGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIW 360
TG GT + F C MRF+LR FPLLTTK+VFWRGVVEELLWFI G TN K L ++G+ IW
Sbjct: 227 TGVGTKTIFSCHMRFSLRDGVFPLLTTKRVFWRGVVEELLWFIRGDTNAKHLSDQGVKIW 286
Query: 361 DGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQ-GFDQLLDVI 416
D N +R++LDG GL REEGDLGPVYGFQWRHFGA Y DMHADY+ G DQL +VI
Sbjct: 287 DLNGTREFLDGRGLTHREEGDLGPVYGFQWRHFGADYVDMHADYSKSGGVDQLAEVI 343
>B9H4E4_POPTR (tr|B9H4E4) Dihydrofolate reductase-thymidylate synthase OS=Populus
trichocarpa GN=DHFR-TS-3a PE=3 SV=1
Length = 252
Score = 284 bits (727), Expect = 1e-74, Method: Compositional matrix adjust.
Identities = 135/200 (67%), Positives = 159/200 (79%), Gaps = 3/200 (1%)
Query: 59 PRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESI 118
P R+YQVVVAATRDMGIGK+GKLPWRLP DLKFFK++TL TSD G++NA++MGRKTWESI
Sbjct: 16 PMRSYQVVVAATRDMGIGKDGKLPWRLPCDLKFFKEITLATSDPGKQNAILMGRKTWESI 75
Query: 119 PLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGG 178
P+++RPLPGRLNVVLTRS F+I ENV+ CG PYC SI+KVF+IGGG
Sbjct: 76 PIKYRPLPGRLNVVLTRS--FEIEDEENVITCGSISSALELLAEAPYCFSIDKVFVIGGG 133
Query: 179 QILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYV 238
QILRE+LN PGCDAIH+TEIETS++CDTFIP ID S FQPWYSS P+VEN +RY F TYV
Sbjct: 134 QILRETLNGPGCDAIHVTEIETSVECDTFIPSIDFSKFQPWYSSPPLVENGIRYSFVTYV 193
Query: 239 RVRVSAVES-HGQDNGLSSD 257
VR S E+ G+ G +D
Sbjct: 194 HVRNSENETIAGKTGGKCND 213
>C5KZ80_9ALVE (tr|C5KZ80) Dihydrofolate reductase/thymidilate synthase, putative
OS=Perkinsus marinus ATCC 50983 GN=Pmar_PMAR018231 PE=4
SV=1
Length = 422
Score = 284 bits (727), Expect = 1e-74, Method: Compositional matrix adjust.
Identities = 160/357 (44%), Positives = 212/357 (59%), Gaps = 26/357 (7%)
Query: 65 VVVAATRDMGIGKEGKLPWR-LPSDLKFFKDVTLT-TSDSGRKNAVIMGRKTWESIPLEH 122
V+VA T GIGK+G+LPW+ LP D+K FK +T + KN IMGRKTWESIP
Sbjct: 8 VIVAHTCKWGIGKDGQLPWKSLPEDMKRFKTITTGGHCNDDVKNVCIMGRKTWESIPERF 67
Query: 123 RPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILR 182
RPL R+NVV++ + S + V IC + I ++F+IGG ++
Sbjct: 68 RPLKDRINVVISSTTS-PADYPQGVRICPSLLDSLASLQQGE--VKIGEIFVIGGASLIT 124
Query: 183 ESLNAPGCDAIHITEIETSI-DCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVR 241
E++ P C ++ T + T +CD F+ KID +++P S +++ + F Y R
Sbjct: 125 EAMQLPQCRTLYTTRVGTDPWECDVFMEKIDEEIWEPIAVSRTFRHSDIPFDFVDYKR-- 182
Query: 242 VSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDR 301
+ K E+ P+ F+ H E+ YLRL+++II +G DDR
Sbjct: 183 ---------------REGFDKTELSLAERCPRGKFQ-HGEYEYLRLIEEIIENGEDADDR 226
Query: 302 TGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIW 360
TG GT + F C MRF+LR FPLLTTK+VFWRGVVEELLWFI G TN K L ++G+ IW
Sbjct: 227 TGVGTKTIFSCHMRFSLRDGVFPLLTTKRVFWRGVVEELLWFIRGDTNAKHLSDQGVKIW 286
Query: 361 DGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQ-GFDQLLDVI 416
D N +R++LDG GL REEGDLGPVYGFQWRHFGA Y DMHADY+ G DQL +VI
Sbjct: 287 DLNGTREFLDGRGLTHREEGDLGPVYGFQWRHFGADYVDMHADYSQSGGVDQLAEVI 343
>B7FQJ9_PHATR (tr|B7FQJ9) Predicted protein (Fragment) OS=Phaeodactylum
tricornutum CCAP 1055/1 GN=PHATRDRAFT_1690 PE=4 SV=1
Length = 495
Score = 275 bits (702), Expect = 9e-72, Method: Compositional matrix adjust.
Identities = 162/375 (43%), Positives = 204/375 (54%), Gaps = 51/375 (13%)
Query: 65 VVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEHRP 124
VV AA GIG +G LPWRLP DL+ F+ VT ++G NAVIMGRKTW+SIP RP
Sbjct: 1 VVAAAASHRGIGYQGSLPWRLPGDLRHFQAVTTQPPETGGTNAVIMGRKTWDSIPDRFRP 60
Query: 125 LPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRES 184
LPGR+NVVLTR + + V+ P ++ VF+IGGGQ+ ++
Sbjct: 61 LPGRINVVLTRHPERTLW--PDGVLTATSLADAAALLAQP-TRAVGHVFVIGGGQVYEQA 117
Query: 185 LNAPGCDAIHITEI---ETSIDCDTFIPKIDSSVF--QPWYSSFPIVE------------ 227
L + + TE+ D F P + + + QPW +S
Sbjct: 118 LREKFVNRVVYTEVANLPADSKFDAFFPPLPDAEWQAQPWQTSTTATNKENGNAPETGAW 177
Query: 228 -----NNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEF 282
+ + Y F Y R +V++V +G + EE
Sbjct: 178 HTDGPSGITYRFLEYTR-KVASVTVQPPTDGNA------------------------EER 212
Query: 283 LYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEELLW 341
YL L + I+ G + DRTGTGTLS+FG QMRF+LR T PLLTTK+VFWRGV EELLW
Sbjct: 213 QYLDLCRHILDHGVRRGDRTGTGTLSQFGTQMRFSLRDGTLPLLTTKRVFWRGVAEELLW 272
Query: 342 FISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMH 401
F++G+TN L K I IWDGN SRD+LD GL RE GDLGPVYGFQWRHFGA Y MH
Sbjct: 273 FVAGNTNANDLAAKDIRIWDGNGSRDFLDSRGLGHREVGDLGPVYGFQWRHFGATYGTMH 332
Query: 402 ADYTGQGFDQLLDVI 416
DYTG+G DQL + I
Sbjct: 333 DDYTGKGVDQLAECI 347
>Q8MXB7_LEITR (tr|Q8MXB7) Dihydrofolate reductase-thymidylate synthase
OS=Leishmania tropica GN=dhfr-ts PE=4 SV=1
Length = 520
Score = 272 bits (696), Expect = 5e-71, Method: Compositional matrix adjust.
Identities = 157/398 (39%), Positives = 213/398 (53%), Gaps = 54/398 (13%)
Query: 37 FSNMAGDSKASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVT 96
S A K + A+ R + +VVA + GIG +PWR+P D+ FFKD T
Sbjct: 1 MSRAAARFKILMPETKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQT 60
Query: 97 LTTSD-----SGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFD----------I 141
+ ++NAV+MGRKTWES+P++ RPL GRLN+VL+ + +
Sbjct: 61 TLLRNKKPPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEEKR 120
Query: 142 ATAEN--VVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA---IHIT 196
A AE VV+ G PYC SIE + +GG Q+ +++ +P + +++T
Sbjct: 121 AAAEQDVVVVNGGLAEALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLT 180
Query: 197 EIETSID-CDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLS 255
I T+ C F P FP + A+ R S E
Sbjct: 181 RIYTTAPACTRFFP-------------FPPENAATAWDLASSQGRRKSEAEG-------- 219
Query: 256 SDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMR 315
++FE+ K+ V HEE YL L+ I+ G +K+DRTG GT+S FG QMR
Sbjct: 220 -----LEFEICKY------VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMR 268
Query: 316 FNLR-RTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGL 374
F+LR PLLTTK+VFWRGV EELLWF+ G TN ++L +K IHIWDGN SR++LD GL
Sbjct: 269 FSLRGNRLPLLTTKRVFWRGVCEELLWFLRGETNARLLADKDIHIWDGNGSREFLDSRGL 328
Query: 375 KDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQL 412
+ +E DLGPVYGFQWRHFGA Y A+Y G+G DQ+
Sbjct: 329 TENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQI 366
>Q8MXB8_LEITR (tr|Q8MXB8) Dihydrofolate reductase-thymidylate synthase
OS=Leishmania tropica GN=dhfr-ts PE=4 SV=1
Length = 520
Score = 271 bits (693), Expect = 1e-70, Method: Compositional matrix adjust.
Identities = 157/398 (39%), Positives = 212/398 (53%), Gaps = 54/398 (13%)
Query: 37 FSNMAGDSKASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVT 96
S A K + A+ R + +VVA + GIG +PWR+P D+ FFKD T
Sbjct: 1 MSRAAARFKILMPETKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQT 60
Query: 97 LTTSD-----SGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFD----------I 141
+ ++NAV+MGRKTWES+P++ RPL GRLN+VL+ + +
Sbjct: 61 TLLRNKKPPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEEKR 120
Query: 142 ATAEN--VVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA---IHIT 196
A AE VV+ G PYC SIE + +GG Q+ +++ +P + +++T
Sbjct: 121 AAAEQDVVVVNGGLAEALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLT 180
Query: 197 EIETSID-CDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLS 255
I T+ C F P FP + A+ R S E
Sbjct: 181 RIYTTAPACTRFFP-------------FPPENAATAWDLASSQGRRKSEAEG-------- 219
Query: 256 SDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMR 315
++FE+ K+ V HEE YL L+ I+ G +K+DRTG GT+S FG QMR
Sbjct: 220 -----LEFEICKY------VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMR 268
Query: 316 FNLR-RTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGL 374
F+LR PLLTTK+VFWRGV EELLWF+ G TN +L +K IHIWDGN SR++LD GL
Sbjct: 269 FSLRGNRLPLLTTKRVFWRGVCEELLWFLRGETNAXLLADKDIHIWDGNGSREFLDSRGL 328
Query: 375 KDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQL 412
+ +E DLGPVYGFQWRHFGA Y A+Y G+G DQ+
Sbjct: 329 TENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQI 366
>A4H4P8_LEIBR (tr|A4H4P8) Dihydrofolate reductase-thymidylate synthase
OS=Leishmania braziliensis GN=LbrM06_V2.0830 PE=4 SV=1
Length = 521
Score = 271 bits (693), Expect = 1e-70, Method: Compositional matrix adjust.
Identities = 148/378 (39%), Positives = 207/378 (54%), Gaps = 53/378 (14%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSD-----SGRKNAVIMGRKTW 115
R + ++VA GIG +PW++P D+ FFKD T + ++NAV+MGR+TW
Sbjct: 25 RCFSIIVAVDEQHGIGDGKTIPWQVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVMGRQTW 84
Query: 116 ESIPLEHRPLPGRLNVVLTRSGSFD------------IATAENVVICGXXXXXXXXXXXX 163
ES+PL++RPL GRLNVVL+ + D A + VV+ G
Sbjct: 85 ESVPLKYRPLKGRLNVVLSSKATVDELLAALPEGKRTAAAQDLVVVNGGLAEALHLLARP 144
Query: 164 PYCLSIEKVFIIGGGQILRESLNAPGCDA---IHITEI-ETSIDCDTFIPKIDSSVFQPW 219
P+C SIE + +GG Q+ +++ AP + +++T I T+ +C F P
Sbjct: 145 PHCSSIETAYCVGGAQVYSDAMTAPCVEKLQEVYLTRIYATAPECTRFYP---------- 194
Query: 220 YSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERH 279
FP + + R S+ +++E++K+ V H
Sbjct: 195 ---FPPTNAAAAAWDLAWTQGRQR------------SETGGVEYEIRKY------VPHNH 233
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR-RTFPLLTTKKVFWRGVVEE 338
EE YL L+ I+ G K+DRTG G LS FG QMRF+LR PLLTTK+VFWRGV EE
Sbjct: 234 EERQYLELIDRIMKTGIAKEDRTGVGILSLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEE 293
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF+ G TN ++L +K IHIWDGN SR++LD GL +E DLGPVYGFQWRHFGA+Y
Sbjct: 294 LLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTANKEMDLGPVYGFQWRHFGAQYK 353
Query: 399 DMHADYTGQGFDQLLDVI 416
A+Y G+G DQ+ ++
Sbjct: 354 GFEANYDGEGVDQIKSIV 371
>Q8MQV3_LEIIN (tr|Q8MQV3) Dihydrofolate reductase/thymidylate synthase
OS=Leishmania infantum PE=4 SV=1
Length = 520
Score = 267 bits (682), Expect = 2e-69, Method: Compositional matrix adjust.
Identities = 155/402 (38%), Positives = 215/402 (53%), Gaps = 54/402 (13%)
Query: 37 FSNMAGDSKASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVT 96
S A K + A+ R + +VVA + GIG +PWR+P D+ FFKD T
Sbjct: 1 MSRAAARFKIPMPATKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQT 60
Query: 97 LTTSD-----SGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAE------ 145
+ ++NAV+MGRKTWES+P++ RPL GRLN+VL+ + + A
Sbjct: 61 TLLRNKKPPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGKR 120
Query: 146 ------NVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA---IHIT 196
VV+ G PYC SIE + +GG Q+ +++ +P + +++T
Sbjct: 121 AAAAQDVVVVNGGLAEALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLT 180
Query: 197 EIETSID-CDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLS 255
I T+ C F P FP + A+ S G+
Sbjct: 181 RIYTTAPACTRFFP-------------FPPENTTTAWDLAS----------SQGRRK--- 214
Query: 256 SDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMR 315
S+ ++FE+ K+ V HEE YL L+ I+ G +K+DRTG GT+S FG QMR
Sbjct: 215 SEADGLEFEICKY------VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMR 268
Query: 316 FNLR-RTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGL 374
F+LR PLLTTK+VFWRGV EELLWF+ G TN ++L +K IHIWDGN SR++LD GL
Sbjct: 269 FSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGL 328
Query: 375 KDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
+ +E DLGPVYGFQWRHFGA Y A+Y G+G DQ+ ++
Sbjct: 329 TENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIRSIV 370
>Q8MQV1_LEICH (tr|Q8MQV1) Dhfr-ts OS=Leishmania chagasi PE=4 SV=1
Length = 520
Score = 266 bits (679), Expect = 4e-69, Method: Compositional matrix adjust.
Identities = 151/378 (39%), Positives = 209/378 (55%), Gaps = 54/378 (14%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSD-----SGRKNAVIMGRKTW 115
R + +VVA + GIG +PWR+P D+ FFKD T + ++NAV+MGRKTW
Sbjct: 25 RAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKPPTEKKRNAVVMGRKTW 84
Query: 116 ESIPLEHRPLPGRLNVVLTRSGSFDIATAE------------NVVICGXXXXXXXXXXXX 163
ES+P++ RPL GRLN+VL+ + + A VV+ G
Sbjct: 85 ESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGKRAAAAQDVVVVNGGLAEALRLLARP 144
Query: 164 PYCLSIEKVFIIGGGQILRESLNAPGCDA---IHITEIETSID-CDTFIPKIDSSVFQPW 219
PYC SIE + +GG Q+ +++ +P + +++T I T+ C F P
Sbjct: 145 PYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP---------- 194
Query: 220 YSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERH 279
FP + A+ S G+ S+ ++FE+ K+ V H
Sbjct: 195 ---FPPENTTTAWDLAS----------SQGRRK---SEADGLEFEICKY------VPRNH 232
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR-RTFPLLTTKKVFWRGVVEE 338
EE YL L+ I+ G +K+DRTG GT+S FG QMRF+LR PLLTTK+VFWRGV EE
Sbjct: 233 EERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEE 292
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF+ G TN ++L +K IHIWDGN SR++LD GL + +E DLGPVYGFQWRHFGA Y
Sbjct: 293 LLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYK 352
Query: 399 DMHADYTGQGFDQLLDVI 416
A+Y G+G DQ+ ++
Sbjct: 353 GFEANYDGEGVDQIRSIV 370
>B5U9U8_BABGI (tr|B5U9U8) Dihydrofolate reductase-thymidylate synthase OS=Babesia
gibsoni GN=Bgdhfr-ts PE=2 SV=1
Length = 515
Score = 265 bits (676), Expect = 1e-68, Method: Compositional matrix adjust.
Identities = 155/370 (41%), Positives = 204/370 (55%), Gaps = 35/370 (9%)
Query: 64 QVVVAATRDMGIGKEGKLPW-RLPSDLKFFKDVT------LTTSDSGRKNAVIMGRKTWE 116
Q++VA + IGK ++PW + D +F VT + + KN VI GRKT+E
Sbjct: 11 QIIVATALNRVIGKNNEIPWPHIRQDFRFLYWVTTFIEPEVKAKNPELKNVVIFGRKTYE 70
Query: 117 SIPLEHRPLPGRLNVVLTRS----------GSFDIATAENVVICGXXXXXXXXXXXXPYC 166
SIP PL GR+NV+++RS S D A E P+
Sbjct: 71 SIPQNVLPLKGRINVLISRSIKEMPGVLTFSSLDAAIKE-------------LRASVPH- 116
Query: 167 LSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIV 226
K+FI+GG +I R L CD I+ T I + D F P+I + F+ S
Sbjct: 117 ---NKIFILGGSEIYRLVLENDLCDKIYQTRINKDYEGDRFFPEIPDT-FEITGISKTFG 172
Query: 227 ENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLR 286
+ V Y F TY + V + H + L K +V ++ P + HEEF YL
Sbjct: 173 TDFVTYDFVTYEKKSVVKDKPHPSMDELVLTGEEPKVKVPQYVACPSVKIRYHEEFQYLD 232
Query: 287 LVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGS 346
++ D++S+G LK +RTGT SKFG QMRF+L ++FPLLTTKKV R ++EELLWFI GS
Sbjct: 233 ILADVLSNGTLKQNRTGTDAYSKFGYQMRFDLSKSFPLLTTKKVALRSIIEELLWFIRGS 292
Query: 347 TNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTG 406
TN L K + IW+ N +R +LD +G DREE DLGPVYGFQWRHFGA+Y DMHADY+G
Sbjct: 293 TNGNDLLAKNVRIWELNGARSFLDNLGFTDREEHDLGPVYGFQWRHFGAKYLDMHADYSG 352
Query: 407 QGFDQLLDVI 416
QG DQL VI
Sbjct: 353 QGIDQLKTVI 362
>Q8T5T9_TRYCR (tr|Q8T5T9) Dihydrofolate reductase-thymidylate synthase
OS=Trypanosoma cruzi PE=4 SV=1
Length = 521
Score = 261 bits (668), Expect = 8e-68, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 21 RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 80
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 81 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 140
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 141 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 190
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 191 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 234
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 235 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 294
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 295 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 354
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 355 THHDANYDGQGVDQIKAIV 373
>D3JLB2_TRYCR (tr|D3JLB2) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 477
Score = 261 bits (668), Expect = 9e-68, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 5 RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 64
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 65 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 124
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 125 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 174
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 175 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 218
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 219 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 278
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 279 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 338
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 339 THHDANYDGQGVDQIKAIV 357
>D3JL96_TRYCR (tr|D3JL96) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 477
Score = 261 bits (668), Expect = 9e-68, Method: Compositional matrix adjust.
Identities = 159/379 (41%), Positives = 204/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 4 RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSFDI------------ATAENVVICGXXXXXXXXXXX 162
W+SIP + RPLPGRLNVVL+ + + + A+++V
Sbjct: 64 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNSHADSIVAVNGGLEQALQLLA 123
Query: 163 XP-YCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
P Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 173
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 174 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 217
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 218 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 277
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 278 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 337
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 338 THHDANYDGQGVDQIKAIV 356
>Q95NI3_TRYCR (tr|Q95NI3) Dihydrofolate reductase-thymidylate synthetase
(Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 491
Score = 261 bits (668), Expect = 9e-68, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 11 RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 71 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 130
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 180
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 181 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 224
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 225 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 284
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 285 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 344
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 345 THHDANYDGQGVDQIKAIV 363
>D3JL87_TRYCR (tr|D3JL87) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 477
Score = 261 bits (668), Expect = 9e-68, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 4 RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 64 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 173
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 174 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 217
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 218 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 277
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 278 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 337
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 338 THHDANYDGQGVDQIKAIV 356
>C9ZTK8_TRYBG (tr|C9ZTK8) Dihydrofolate reductase-thymidylate synthase
OS=Trypanosoma brucei gambiense DAL972 GN=TbgDal_VII6360
PE=4 SV=1
Length = 527
Score = 261 bits (667), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 163/391 (41%), Positives = 206/391 (52%), Gaps = 55/391 (14%)
Query: 52 TANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRK 105
I P R + VVVA+ GIG G +PW +P D+++F+ VT ++
Sbjct: 18 AGKISRPPLRPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKR 77
Query: 106 NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGS-----------FDIATAEN--VVICGX 152
NAV+MGRKTW+S+P + RPL RLNVVL+RS + A A N V + G
Sbjct: 78 NAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGG 137
Query: 153 XXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCD---AIHITEIE-TSIDCDTF- 207
+ SIE VF IGGG I +++L AP + AIH T + S C F
Sbjct: 138 LEDALRMLVSKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFF 197
Query: 208 -IPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVK 266
IP + + +V ++ T RV A K
Sbjct: 198 DIPAAGTKTLE----GLELVRESI-----TDERVSTGAGG-------------------K 229
Query: 267 KFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLL 325
K+ F K+V EE YL LV II +G K DRTG GT S FG QMRF+LR PLL
Sbjct: 230 KYQF-EKLVPRNSEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLL 288
Query: 326 TTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPV 385
TTK+VFWRGV EELLWF+ G TN K+L +KGIHIWDGN SR +LD GL D +E DLGPV
Sbjct: 289 TTKRVFWRGVCEELLWFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPV 348
Query: 386 YGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
YGFQWRHFGA Y D G+G DQ+ +++
Sbjct: 349 YGFQWRHFGADYISCKVDSEGKGVDQIANIV 379
>D3JL83_TRYCR (tr|D3JL83) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 476
Score = 261 bits (667), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 4 RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 64 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 173
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 174 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 217
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 218 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 277
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 278 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 337
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 338 THHDANYDGQGVDQIKAIV 356
>D3JLB1_TRYCR (tr|D3JLB1) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 471
Score = 261 bits (667), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 4 RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 64 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 173
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 174 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 217
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 218 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 277
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 278 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 337
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 338 THHDANYDGQGVDQIKAIV 356
>Q8T5T8_TRYCR (tr|Q8T5T8) Dihydrofolate reductase-thymidylate synthase
OS=Trypanosoma cruzi PE=4 SV=1
Length = 521
Score = 261 bits (667), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 21 RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 80
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 81 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 140
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 141 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 190
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 191 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 234
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 235 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 294
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 295 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 354
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 355 THHDANYDGQGVDQIKAIV 373
>Q582G3_9TRYP (tr|Q582G3) Dihydrofolate reductase-thymidylate synthase
OS=Trypanosoma brucei GN=Tb927.7.5480 PE=4 SV=1
Length = 527
Score = 261 bits (667), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 163/391 (41%), Positives = 206/391 (52%), Gaps = 55/391 (14%)
Query: 52 TANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRK 105
I P R + VVVA+ GIG G +PW +P D+++F+ VT ++
Sbjct: 18 AGKISRPPLRPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKR 77
Query: 106 NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGS-----------FDIATAEN--VVICGX 152
NAV+MGRKTW+S+P + RPL RLNVVL+RS + A A N V + G
Sbjct: 78 NAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGG 137
Query: 153 XXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCD---AIHITEIE-TSIDCDTF- 207
+ SIE VF IGGG I +++L AP + AIH T + S C F
Sbjct: 138 LEDALRMLVSKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFF 197
Query: 208 -IPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVK 266
IP + + +V ++ T RV A K
Sbjct: 198 DIPAAGTKTLE----GLELVRESI-----TDERVSTGAGG-------------------K 229
Query: 267 KFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLL 325
K+ F K+V EE YL LV II +G K DRTG GT S FG QMRF+LR PLL
Sbjct: 230 KYQF-EKLVPRNSEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLL 288
Query: 326 TTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPV 385
TTK+VFWRGV EELLWF+ G TN K+L +KGIHIWDGN SR +LD GL D +E DLGPV
Sbjct: 289 TTKRVFWRGVCEELLWFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPV 348
Query: 386 YGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
YGFQWRHFGA Y D G+G DQ+ +++
Sbjct: 349 YGFQWRHFGADYISCKEDSEGKGVDQIANIV 379
>D3JLA1_TRYCR (tr|D3JLA1) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 477
Score = 261 bits (667), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 4 RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 64 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 173
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 174 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 217
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 218 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 277
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 278 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 337
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 338 THHDANYDGQGVDQIKAIV 356
>Q95NS0_TRYCR (tr|Q95NS0) Dihydrofolate reductase-thymidylate synthetase
(Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 491
Score = 261 bits (667), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 11 RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 71 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 130
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 180
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 181 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 224
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 225 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 284
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 285 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 344
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 345 THHDANYDGQGVDQIKAIV 363
>D3JL86_TRYCR (tr|D3JL86) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 476
Score = 261 bits (667), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 4 RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 64 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 173
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 174 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 217
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 218 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 277
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 278 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 337
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 338 THHDANYDGQGVDQIKAIV 356
>D3JL82_TRYCR (tr|D3JL82) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 478
Score = 261 bits (666), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 4 RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 64 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 124 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 173
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 174 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 217
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 218 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 277
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 278 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 337
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 338 THHDANYDGQGVDQIKAIV 356
>Q963S7_9TRYP (tr|Q963S7) Dihydrofolate reductase-thymidylate synthetase
(Fragment) OS=Trypanosoma vespertilionis GN=DHFR-TS PE=4
SV=1
Length = 491
Score = 261 bits (666), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 158/380 (41%), Positives = 203/380 (53%), Gaps = 51/380 (13%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFFKDVT ++NAV+MGRKT
Sbjct: 11 RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFKDVTTKLRGKNVKPSPAKRNAVVMGRKT 70
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 71 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLQDEEKRNLYADSIVAVNGGLEQALQLLA 130
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETS-IDCDTFIPKIDSSVFQ 217
Y SIE V+ IGGG + E+L P AI+ T I S C F V +
Sbjct: 131 SLNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFF-----HVPE 185
Query: 218 PWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFE 277
P +E + R +S + S++ + K+ + K++
Sbjct: 186 PGTEPAAGIE---------WQRETIS-------EELTSANGNETKY------YFEKLIPR 223
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVV 336
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV
Sbjct: 224 NREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVC 283
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA
Sbjct: 284 EELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAA 343
Query: 397 YTDMHADYTGQGFDQLLDVI 416
YT A+Y GQG DQ+ ++
Sbjct: 344 YTHHDANYDGQGVDQIKAIV 363
>Q95NT2_TRYCR (tr|Q95NT2) Dihydrofolate reductase-thymidylate synthetase
(Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 491
Score = 261 bits (666), Expect = 1e-67, Method: Compositional matrix adjust.
Identities = 158/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 11 RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 71 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 130
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 180
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 181 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 224
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 225 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 284
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 285 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 344
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 345 THHDANYDGQGVDQIKAIV 363
>Q4DLS1_TRYCR (tr|Q4DLS1) Dihydrofolate reductase-thymidylate synthase, putative
OS=Trypanosoma cruzi GN=Tc00.1047053509153.90 PE=4 SV=1
Length = 521
Score = 260 bits (664), Expect = 2e-67, Method: Compositional matrix adjust.
Identities = 157/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+D+T ++NAV+MGRKT
Sbjct: 21 RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 80
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 81 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 140
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 141 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 190
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 191 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 234
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 235 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 294
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 295 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 354
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 355 THHDANYDGQGVDQIKAIV 373
>Q95NX3_TRYCR (tr|Q95NX3) Dihydrofolate reductase-thymidylate synthetase
(Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 491
Score = 260 bits (664), Expect = 2e-67, Method: Compositional matrix adjust.
Identities = 157/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+D+T ++NAV+MGRKT
Sbjct: 11 RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 70
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 71 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 130
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 131 SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 180
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 181 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 224
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 225 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 284
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 285 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 344
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 345 THHDANYDGQGVDQIKAIV 363
>Q95NY4_TRYCR (tr|Q95NY4) Dihydrofolate reductase-thymidylate synthetase
(Fragment) OS=Trypanosoma cruzi marinkellei GN=DHFR-TS
PE=4 SV=1
Length = 491
Score = 260 bits (664), Expect = 3e-67, Method: Compositional matrix adjust.
Identities = 159/379 (41%), Positives = 202/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + ++VA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 11 RAFSLIVAVDEHGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 70
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 71 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLYADSIVAVNGGLEQALQLLA 130
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 131 SLNYTSSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 180
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ A R + E NG S+ Y + K++
Sbjct: 181 ----FHVPESGTEPA-AGIEWQRETISEELTSANG--SETKY---------YFEKLIPRN 224
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 225 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 284
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 285 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGADY 344
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 345 THHDANYDGQGVDQIKTIV 363
>D3JLA6_TRYCR (tr|D3JLA6) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 477
Score = 259 bits (661), Expect = 5e-67, Method: Compositional matrix adjust.
Identities = 157/379 (41%), Positives = 201/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+DVT ++NAV+MGRKT
Sbjct: 4 RAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKT 63
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 64 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLA 123
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SIE + IGGG + E+L P AI+ T I S + SVF
Sbjct: 124 SPNYTPSIETFYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 173
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 174 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 217
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 218 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 277
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 278 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 337
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 338 THHDANYDGQGVDQIKAIV 356
>Q963S8_TRYCR (tr|Q963S8) Dihydrofolate reductase-thymidylate synthetase
(Fragment) OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 491
Score = 257 bits (656), Expect = 2e-66, Method: Compositional matrix adjust.
Identities = 156/379 (41%), Positives = 201/379 (53%), Gaps = 49/379 (12%)
Query: 61 RTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKT 114
R + +VVA GIG +PW +P D+KFF+D+T ++NAV+MGRKT
Sbjct: 11 RAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKT 70
Query: 115 WESIPLEHRPLPGRLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXX 161
W+SIP + RPLPGRLNVVL+ + + ++ V + G
Sbjct: 71 WDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA 130
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQP 218
Y SI V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 131 SPNYTPSIGTVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF-- 180
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFER 278
F + E+ +A Q +S + + K+ F K++
Sbjct: 181 ----FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRN 224
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV E
Sbjct: 225 REEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCE 284
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA Y
Sbjct: 285 ELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAY 344
Query: 398 TDMHADYTGQGFDQLLDVI 416
T A+Y GQG DQ+ ++
Sbjct: 345 THHDANYDGQGVDQIKAIV 363
>Q4QIZ1_LEIMA (tr|Q4QIZ1) Dihydrofolate reductase-thymidylate synthase
OS=Leishmania major GN=LmjF06.0860 PE=4 SV=1
Length = 520
Score = 256 bits (654), Expect = 3e-66, Method: Compositional matrix adjust.
Identities = 152/398 (38%), Positives = 209/398 (52%), Gaps = 54/398 (13%)
Query: 37 FSNMAGDSKASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVT 96
S A K + A+ R + +VVA GIG +PWR+P D+ FFK+ T
Sbjct: 1 MSRAAARFKIPMPETKADFAFPSLRAFSIVVALDMQHGIGDGESIPWRVPEDMTFFKNQT 60
Query: 97 LTTSD-----SGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAE------ 145
+ ++NAV+MGRKTWES+P++ RPL GRLN+VL+ + + A
Sbjct: 61 TLLRNKKPPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGQR 120
Query: 146 ------NVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA---IHIT 196
VV+ G YC SIE + +GG Q+ +++ +P + +++T
Sbjct: 121 AAAAQDVVVVNGGLAEALRLLARPLYCSSIETAYCVGGAQVYADAMLSPCIEKLQEVYLT 180
Query: 197 EI-ETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLS 255
I T+ C F P FP + A+ R S E
Sbjct: 181 RIYATAPACTRFFP-------------FPPENAATAWDLASSQGRRKSEAEG-------- 219
Query: 256 SDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMR 315
++FE+ K+ V HEE YL L+ I+ G +K+DRTG GT+S FG QMR
Sbjct: 220 -----LEFEICKY------VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMR 268
Query: 316 FNLR-RTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGL 374
F+LR PLLTTK+VFWRGV EELLWF+ G T+ ++L +K IHIWDGN SR++LD GL
Sbjct: 269 FSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETSAQLLADKDIHIWDGNGSREFLDSRGL 328
Query: 375 KDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQL 412
+ +E DLGPVYGFQWRHFGA Y A+Y G+G DQ+
Sbjct: 329 TENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQI 366
>B9QD29_TOXGO (tr|B9QD29) Bifunctional dihydrofolate reductase-thymidylate
synthase, putative OS=Toxoplasma gondii VEG
GN=TGVEG_002710 PE=4 SV=1
Length = 610
Score = 256 bits (654), Expect = 4e-66, Method: Compositional matrix adjust.
Identities = 165/454 (36%), Positives = 218/454 (48%), Gaps = 103/454 (22%)
Query: 65 VVVAATRDMGIGKEGKLPW-RLPSDLKFFKDVTLTTS------------------DSG-- 103
+VVA T GIG LPW L +D K F VT TT DSG
Sbjct: 7 LVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLP 66
Query: 104 ------RKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS-GSFDIAT-------AENVVI 149
R NAV+MGRKTWES+P + RPL RLN+V++ S DIA + V +
Sbjct: 67 SPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRV 126
Query: 150 CGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIP 209
C Y S++++F++GG + +L+ ++IT + CD F P
Sbjct: 127 CASLPAALSLLEEE-YKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFP 185
Query: 210 -----------------------------------KIDSSVFQPWYSSFPIVENNVRYCF 234
K + + ++P + S +N V Y F
Sbjct: 186 AFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDF 245
Query: 235 ATYVRVRVSAVESHGQ-DNGLSS------------------------------DNSYIKF 263
+ R + + + N +SS + K
Sbjct: 246 VVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKR 305
Query: 264 EVKKF-SFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTF 322
E K+ +P + F HEEF YL L+ DII++G DDRTG G +SKFGC MR++L + F
Sbjct: 306 EQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAF 365
Query: 323 PLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDL 382
PLLTTK+VFW+GV+EELLWFI G TN L EKG+ IWD N +R++LD L RE GD+
Sbjct: 366 PLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDI 425
Query: 383 GPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GP YGFQWRHFGA Y DMH DYTGQG DQL +VI
Sbjct: 426 GPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVI 459
>B9PR34_TOXGO (tr|B9PR34) Bifunctional dihydrofolate reductase-thymidylate
synthase, putative OS=Toxoplasma gondii GN=TGGT1_100740
PE=4 SV=1
Length = 610
Score = 256 bits (654), Expect = 4e-66, Method: Compositional matrix adjust.
Identities = 165/454 (36%), Positives = 218/454 (48%), Gaps = 103/454 (22%)
Query: 65 VVVAATRDMGIGKEGKLPW-RLPSDLKFFKDVTLTTS------------------DSG-- 103
+VVA T GIG LPW L +D K F VT TT DSG
Sbjct: 7 LVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLP 66
Query: 104 ------RKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS-GSFDIAT-------AENVVI 149
R NAV+MGRKTWES+P + RPL RLN+V++ S DIA + V +
Sbjct: 67 SPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRV 126
Query: 150 CGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIP 209
C Y S++++F++GG + +L+ ++IT + CD F P
Sbjct: 127 CASLPAALSLLEEE-YKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFP 185
Query: 210 -----------------------------------KIDSSVFQPWYSSFPIVENNVRYCF 234
K + + ++P + S +N V Y F
Sbjct: 186 AFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDF 245
Query: 235 ATYVRVRVSAVESHGQ-DNGLSS------------------------------DNSYIKF 263
+ R + + + N +SS + K
Sbjct: 246 VVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKR 305
Query: 264 EVKKF-SFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTF 322
E K+ +P + F HEEF YL L+ DII++G DDRTG G +SKFGC MR++L + F
Sbjct: 306 EQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAF 365
Query: 323 PLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDL 382
PLLTTK+VFW+GV+EELLWFI G TN L EKG+ IWD N +R++LD L RE GD+
Sbjct: 366 PLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDI 425
Query: 383 GPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GP YGFQWRHFGA Y DMH DYTGQG DQL +VI
Sbjct: 426 GPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVI 459
>B6KHC9_TOXGO (tr|B6KHC9) Bifunctional dihydrofolate reductase / thymidylate
synthase OS=Toxoplasma gondii ME49 GN=TGME49_049180 PE=4
SV=1
Length = 610
Score = 256 bits (654), Expect = 4e-66, Method: Compositional matrix adjust.
Identities = 165/454 (36%), Positives = 218/454 (48%), Gaps = 103/454 (22%)
Query: 65 VVVAATRDMGIGKEGKLPW-RLPSDLKFFKDVTLTTS------------------DSG-- 103
+VVA T GIG LPW L +D K F VT TT DSG
Sbjct: 7 LVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLP 66
Query: 104 ------RKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS-GSFDIAT-------AENVVI 149
R NAV+MGRKTWES+P + RPL RLN+V++ S DIA + V +
Sbjct: 67 SPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRV 126
Query: 150 CGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIP 209
C Y S++++F++GG + +L+ ++IT + CD F P
Sbjct: 127 CASLPAALSLLEEE-YKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFP 185
Query: 210 -----------------------------------KIDSSVFQPWYSSFPIVENNVRYCF 234
K + + ++P + S +N V Y F
Sbjct: 186 AFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDF 245
Query: 235 ATYVRVRVSAVESHGQ-DNGLSS------------------------------DNSYIKF 263
+ R + + + N +SS + K
Sbjct: 246 VVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKR 305
Query: 264 EVKKF-SFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTF 322
E K+ +P + F HEEF YL L+ DII++G DDRTG G +SKFGC MR++L + F
Sbjct: 306 EQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAF 365
Query: 323 PLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDL 382
PLLTTK+VFW+GV+EELLWFI G TN L EKG+ IWD N +R++LD L RE GD+
Sbjct: 366 PLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDI 425
Query: 383 GPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GP YGFQWRHFGA Y DMH DYTGQG DQL +VI
Sbjct: 426 GPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVI 459
>C6T8H1_SOYBN (tr|C6T8H1) Putative uncharacterized protein OS=Glycine max PE=2
SV=1
Length = 139
Score = 255 bits (652), Expect = 6e-66, Method: Compositional matrix adjust.
Identities = 117/136 (86%), Positives = 126/136 (92%)
Query: 274 MVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWR 333
M+ ERHEE+LYL+LVQDII++G K DRTGTGTLSKFGCQMRFNLR FPLLTTKKVFWR
Sbjct: 1 MISERHEEYLYLKLVQDIIAEGTTKGDRTGTGTLSKFGCQMRFNLRGNFPLLTTKKVFWR 60
Query: 334 GVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHF 393
GVVEELLWFISGSTN KVLQEKGIHIWDGNASR+YLDG+GL +REEGDLGPVYGFQWRHF
Sbjct: 61 GVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDGVGLTEREEGDLGPVYGFQWRHF 120
Query: 394 GARYTDMHADYTGQGF 409
GARYTDMH DY+GQG
Sbjct: 121 GARYTDMHHDYSGQGL 136
>D3JLA7_TRYCR (tr|D3JLA7) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Trypanosoma cruzi GN=DHFR-TS PE=4 SV=1
Length = 462
Score = 254 bits (650), Expect = 1e-65, Method: Compositional matrix adjust.
Identities = 154/366 (42%), Positives = 196/366 (53%), Gaps = 49/366 (13%)
Query: 74 GIGKEGKLPWRLPSDLKFFKDVTL------TTSDSGRKNAVIMGRKTWESIPLEHRPLPG 127
GIG +PW +P D+KFF+DVT ++NAV+MGRKTW+SIP + RPLPG
Sbjct: 3 GIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKTWDSIPPKFRPLPG 62
Query: 128 RLNVVLTRSGSF-------------DIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFI 174
RLNVVL+ + + ++ V + G Y SIE V+
Sbjct: 63 RLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLASPNYTPSIETVYC 122
Query: 175 IGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVR 231
IGGG + E+L P AI+ T I S + SVF F + E+
Sbjct: 123 IGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF------FRVPESGTE 168
Query: 232 YCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDI 291
+A Q +S + + K+ F K++ EE YL LV I
Sbjct: 169 -----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRNREEEQYLSLVDRI 216
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVEELLWFISGSTNCK 350
I +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV EELLWF+ G T K
Sbjct: 217 IREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFLRGETYAK 276
Query: 351 VLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFD 410
L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA YT A+Y GQG D
Sbjct: 277 KLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAYTHHDANYDGQGVD 336
Query: 411 QLLDVI 416
Q+ ++
Sbjct: 337 QIKAIV 342
>A7ASX7_BABBO (tr|A7ASX7) Dihydrofolate reductase/thymidylate synthase OS=Babesia
bovis GN=BBOV_II000780 PE=1 SV=1
Length = 511
Score = 253 bits (647), Expect = 2e-65, Method: Compositional matrix adjust.
Identities = 145/363 (39%), Positives = 198/363 (54%), Gaps = 23/363 (6%)
Query: 65 VVVAATRDMGIGKEGKLPW-RLPSDLKFFKDVT------LTTSDSGRKNAVIMGRKTWES 117
+ VA + IG + ++PW + D +F ++ T + + + +N VI GRKT+ES
Sbjct: 13 IFVAVALNKVIGHKNQIPWPHITHDFRFLRNGTTYIPPEVLSKNPDIQNVVIFGRKTYES 72
Query: 118 IPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGG 177
IP PL R+NV+L+R T + V C + K+FI+GG
Sbjct: 73 IPKASLPLKNRINVILSR-------TVKEVPGCLVYEDLSTAIRDLRANVPHNKIFILGG 125
Query: 178 GQILRESLNAPGCDAIHITEIETSIDCDTFIPKI----DSSVFQPWYSSFPIVENNVRYC 233
+ +E L+ CD I++T + DT+ P I + + P +S+ + V Y
Sbjct: 126 SFLYKEVLDNGLCDKIYLTRLNKEYPGDTYFPDIPDTFEITAISPTFST-----DFVSYD 180
Query: 234 FATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIIS 293
F Y R V + L + I K+ P + HEEF YL ++ D++S
Sbjct: 181 FVIYERKDCKTVFPDPPFDQLLMTGTDISVPKPKYVACPGVRIRNHEEFQYLDILADVLS 240
Query: 294 DGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQ 353
G LK +RTGT SKFG QMRF+L R+FPLLTTKKV R ++EELLWFI GSTN L
Sbjct: 241 HGVLKPNRTGTDAYSKFGYQMRFDLSRSFPLLTTKKVALRSIIEELLWFIKGSTNGNDLL 300
Query: 354 EKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLL 413
K + IW+ N RD+LD G DREE DLGP+YGFQWRHFGA Y DMHADYTG+G DQL
Sbjct: 301 AKNVRIWELNGRRDFLDKNGFTDREEHDLGPIYGFQWRHFGAEYLDMHADYTGKGIDQLA 360
Query: 414 DVI 416
++I
Sbjct: 361 EII 363
>Q5CGA3_CRYHO (tr|Q5CGA3) Chain A, crystal structure of Dhfr OS=Cryptosporidium
hominis GN=Chro.40506 PE=1 SV=1
Length = 521
Score = 253 bits (645), Expect = 4e-65, Method: Compositional matrix adjust.
Identities = 148/371 (39%), Positives = 201/371 (54%), Gaps = 26/371 (7%)
Query: 65 VVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEHRP 124
VV A+ GIG G+LPW + DLKFF +T DS +KNA+IMGRKTW+SI RP
Sbjct: 9 VVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIG--RRP 66
Query: 125 LPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRES 184
L R+ VV++ S D A VV SIE +F+ GG I R++
Sbjct: 67 LKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDD----SIENIFVCGGESIYRDA 122
Query: 185 LNAPGCDAIHITEIE-TSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVS 243
L D I++T + I+ DT+ P+I + F P Y S N+ Y F + +
Sbjct: 123 LKDNFVDRIYLTRVALEDIEFDTYFPEIPET-FLPVYMSQTFCTKNISYDFMIFEKQEKK 181
Query: 244 AVES-----------------HGQDNGLSSDNSYIKFEVKKFSFLPKMVFER-HEEFLYL 285
+++ G+ G+ + KF ++ P + F R H EF YL
Sbjct: 182 TLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYL 241
Query: 286 RLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISG 345
L+ ++ +G +++RTG T S FG MRF++R +FPLLTTKKV R + EEL+WFI G
Sbjct: 242 DLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKG 301
Query: 346 STNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYT 405
TN L EK ++IW GN S++YL+ IGL REE DLGP+YGFQWRH+ Y MH DYT
Sbjct: 302 DTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYT 361
Query: 406 GQGFDQLLDVI 416
G G DQL +I
Sbjct: 362 GVGVDQLAKLI 372
>Q27552_CRYPV (tr|Q27552) Bifunctional dihydrofolate reductase-thymidylate
synthase OS=Cryptosporidium parvum GN=DHFR-TS PE=1 SV=1
Length = 521
Score = 253 bits (645), Expect = 4e-65, Method: Compositional matrix adjust.
Identities = 148/371 (39%), Positives = 201/371 (54%), Gaps = 26/371 (7%)
Query: 65 VVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEHRP 124
VV A+ GIG G+LPW + DLKFF +T DS +KNA+IMGRKTW+SI RP
Sbjct: 9 VVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIG--RRP 66
Query: 125 LPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRES 184
L R+ VV++ S D A VV SIE +F+ GG I R++
Sbjct: 67 LKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDD----SIENIFVCGGESIYRDA 122
Query: 185 LNAPGCDAIHITEIE-TSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVS 243
L D I++T + I+ DT+ P+I + F P Y S N+ Y F + +
Sbjct: 123 LKDNFVDRIYLTRVALEDIEFDTYFPEIPET-FLPVYMSQTFCTKNISYDFMIFEKQEKK 181
Query: 244 AVES-----------------HGQDNGLSSDNSYIKFEVKKFSFLPKMVFER-HEEFLYL 285
+++ G+ G+ + KF ++ P + F R H EF YL
Sbjct: 182 TLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYL 241
Query: 286 RLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISG 345
L+ ++ +G +++RTG T S FG MRF++R +FPLLTTKKV R + EEL+WFI G
Sbjct: 242 DLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKG 301
Query: 346 STNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYT 405
TN L EK ++IW GN S++YL+ IGL REE DLGP+YGFQWRH+ Y MH DYT
Sbjct: 302 DTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYT 361
Query: 406 GQGFDQLLDVI 416
G G DQL +I
Sbjct: 362 GVGVDQLAKLI 372
>Q27551_CRYPV (tr|Q27551) Bifunctional dihydrofolate reductase-thymidylate
synthase (Fragment) OS=Cryptosporidium parvum GN=DHFR-TS
PE=4 SV=1
Length = 499
Score = 252 bits (643), Expect = 6e-65, Method: Compositional matrix adjust.
Identities = 148/371 (39%), Positives = 203/371 (54%), Gaps = 26/371 (7%)
Query: 65 VVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEHRP 124
VV A+ GIG G+LPW + DLKFF +T DS +KNA+IMGRKTW+SI RP
Sbjct: 9 VVAASVLSRGIGINGQLPWSISEDLKFFSKITSNNCDSNKKNALIMGRKTWDSIG--RRP 66
Query: 125 LPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRES 184
L R VV++ S D A +V +IE +F+ GG I R++
Sbjct: 67 LKNRKIVVISSSLPQDEADPNVIVFRNLEDSIKNLMNDD----TIENIFVCGGESIYRDA 122
Query: 185 LNAPGCDAIHITEIE-TSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATY------ 237
L D I++T + I+ DT+ P+I + F P Y S N+ Y F +
Sbjct: 123 LKDNFVDRIYLTRVALEDIEFDTYFPEIPET-FLPVYMSQTFCTKNISYDFMVFEKQEKK 181
Query: 238 -------VRVRVSAVESH----GQDNGLSSDNSYIKFEVKKFSFLPKMVFER-HEEFLYL 285
VR ++ +++ G+ G+ + KF ++ P + F R H EF YL
Sbjct: 182 TLQNCDPVRGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYL 241
Query: 286 RLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISG 345
L+ ++ +G +++RTG T S FG MRF++R +FPLLTTKKV R + EEL+WFI G
Sbjct: 242 DLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKG 301
Query: 346 STNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYT 405
TN L EK ++IW GN S++YL+ IGL REE DLGP+YGFQWRH+ Y MH DYT
Sbjct: 302 DTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYT 361
Query: 406 GQGFDQLLDVI 416
G G DQL +I
Sbjct: 362 GVGVDQLAKLI 372
>Q5CPQ4_CRYPV (tr|Q5CPQ4) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Cryptosporidium parvum Iowa II GN=cgd4_4460 PE=4 SV=1
Length = 531
Score = 252 bits (643), Expect = 7e-65, Method: Compositional matrix adjust.
Identities = 148/371 (39%), Positives = 203/371 (54%), Gaps = 26/371 (7%)
Query: 65 VVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEHRP 124
VV A+ GIG G+LPW + DLKFF +T DS +KNA+IMGRKTW+SI RP
Sbjct: 19 VVAASVLSRGIGINGQLPWSISEDLKFFSKITSNNCDSNKKNALIMGRKTWDSIG--RRP 76
Query: 125 LPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRES 184
L R VV++ S D A +V +IE +F+ GG I R++
Sbjct: 77 LKNRKIVVISSSLPQDEADPNVIVFRNLEDSIKNLMNDD----TIENIFVCGGESIYRDA 132
Query: 185 LNAPGCDAIHITEIETS-IDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATY------ 237
L D I++T + I+ DT+ P+I + F P Y S N+ Y F +
Sbjct: 133 LKDNFVDRIYLTRVALEDIEFDTYFPEIPET-FLPVYMSQTFCTKNISYDFMVFEKQEKK 191
Query: 238 -------VRVRVSAVESH----GQDNGLSSDNSYIKFEVKKFSFLPKMVFER-HEEFLYL 285
VR ++ +++ G+ G+ + KF ++ P + F R H EF YL
Sbjct: 192 TLQNCDPVRGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYL 251
Query: 286 RLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISG 345
L+ ++ +G +++RTG T S FG MRF++R +FPLLTTKKV R + EEL+WFI G
Sbjct: 252 DLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKG 311
Query: 346 STNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYT 405
TN L EK ++IW GN S++YL+ IGL REE DLGP+YGFQWRH+ Y MH DYT
Sbjct: 312 DTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYT 371
Query: 406 GQGFDQLLDVI 416
G G DQL +I
Sbjct: 372 GVGVDQLAKLI 382
>Q7Z0Z9_BABBO (tr|Q7Z0Z9) Dihydrofolate reductase/thymidilate synthase OS=Babesia
bovis PE=4 SV=1
Length = 511
Score = 250 bits (638), Expect = 3e-64, Method: Compositional matrix adjust.
Identities = 144/363 (39%), Positives = 197/363 (54%), Gaps = 23/363 (6%)
Query: 65 VVVAATRDMGIGKEGKLPW-RLPSDLKFFKDVT------LTTSDSGRKNAVIMGRKTWES 117
+ VA + IG + ++PW + D +F ++ T + + + +N VI GRKT+ES
Sbjct: 13 IYVAIALNRVIGHQNQIPWPHIIHDFRFLRNGTTYIPPEVLSKNPNIQNVVIFGRKTYES 72
Query: 118 IPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGG 177
IP PL R+NV+++R T + V C + K+FI+GG
Sbjct: 73 IPKASLPLKNRINVIISR-------TVKEVPGCLVYEDLSTAIRDLRANVPHNKIFILGG 125
Query: 178 GQILRESLNAPGCDAIHITEIETSIDCDTFIPKI----DSSVFQPWYSSFPIVENNVRYC 233
+ +E L+ CD I++T I DTF P I + + P +S+ + V Y
Sbjct: 126 SYLYKEVLDNGLCDKIYLTRINKEYPGDTFFPDIPDTFEITAISPTFST-----DFVSYD 180
Query: 234 FATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIIS 293
F Y R V + L I K+ P + HEEF YL ++ D++S
Sbjct: 181 FVIYERKDCKTVFPDPPFDQLLLKGVDIIVPKPKYVACPGVRIRNHEEFQYLDILADVLS 240
Query: 294 DGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQ 353
G LK +RTGT SKFG QMRF+L R+FPLLTTKKV R ++EELLWFI GSTN L
Sbjct: 241 HGVLKPNRTGTDAYSKFGYQMRFDLSRSFPLLTTKKVALRSIIEELLWFIKGSTNGNDLL 300
Query: 354 EKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLL 413
K + IW+ N R++LD G +REE DLGP+YGFQWRHFGA Y DMHADYTG+G DQL
Sbjct: 301 AKNVRIWELNGRREFLDKNGFTEREEHDLGPIYGFQWRHFGAEYLDMHADYTGKGIDQLA 360
Query: 414 DVI 416
++I
Sbjct: 361 EII 363
>Q4A320_EHV86 (tr|Q4A320) Bifunctional dihydrofolate reductase-thymidylate
synthase OS=Emiliania huxleyi virus 86 GN=EhV113 PE=4
SV=1
Length = 480
Score = 244 bits (623), Expect = 1e-62, Method: Compositional matrix adjust.
Identities = 143/364 (39%), Positives = 192/364 (52%), Gaps = 51/364 (14%)
Query: 65 VVVAATR----DMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPL 120
+VVA + + IG K+PW +D+ F+ +T +TS +N VIMG KTW+SI
Sbjct: 8 IVVAGAKCSDGRIAIGINNKIPWNSKADMHNFRQLTTSTSMPICENVVIMGTKTWQSIG- 66
Query: 121 EHRPLPGRLNVVLTRS-GSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQ 179
+ LP R N+V++R+ + + N V G IE +++IGG
Sbjct: 67 --KRLPNRYNIVISRNKDARRVYNIPNNV--GISSSIELAISELKTVSDIETIYVIGGSY 122
Query: 180 ILRESLNAPGCDAIHITEIETSID------CDTFIPKIDSSVFQPWYSSFPIVENNVRYC 233
I ++ ++ D IH+T + D CDTF FP+ N++
Sbjct: 123 IYKDVIDLKIVDKIHMTFVSNQHDPGAFDNCDTF---------------FPLTVNDL--- 164
Query: 234 FATYVRVRVSAVESHGQDNGLSSDNSYIKFEVK-KFSFLPKMVFERHEEFLYLRLVQDII 292
+ N + S SY+ E S+ HEE+ YL+L+ ++
Sbjct: 165 ----------------ESNFIKSKTSYVTKEAHLTCSYHTYKATVIHEEYQYLQLISKVL 208
Query: 293 SDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVL 352
G + DRTGTGT+S FG MRFNL FPLLTTK+ +W+G+VEELLWFI GSTN L
Sbjct: 209 EHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWFIRGSTNANEL 268
Query: 353 QEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQL 412
K + IWDGN SRD+LD +GL D EEGDLGPVYGFQWRHFGA Y MH Y QG DQL
Sbjct: 269 AAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHDSYDSQGTDQL 328
Query: 413 LDVI 416
+VI
Sbjct: 329 QNVI 332
>D2TF54_9VIRU (tr|D2TF54) Bifunctional dihydrofolate reductase-thymidylate
synthase OS=Emiliania huxleyi virus 99B1 GN=EhV113 PE=4
SV=1
Length = 480
Score = 243 bits (621), Expect = 2e-62, Method: Compositional matrix adjust.
Identities = 143/364 (39%), Positives = 191/364 (52%), Gaps = 51/364 (14%)
Query: 65 VVVAATR----DMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPL 120
+VVA + + IG K+PW +D+ F+ +T +TS +N VIMG KTW+SI
Sbjct: 8 IVVAGAKCSDGRIAIGINNKIPWNSKADMHNFRQLTTSTSMPICENVVIMGAKTWQSIG- 66
Query: 121 EHRPLPGRLNVVLTRS-GSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQ 179
+ LP R N+V++R+ + + N V G IE +++IGG
Sbjct: 67 --KRLPNRYNIVISRNKDARRVYNIPNNV--GISSSIELAISELKTVSDIETIYVIGGSY 122
Query: 180 ILRESLNAPGCDAIHITEIETSID------CDTFIPKIDSSVFQPWYSSFPIVENNVRYC 233
I ++ ++ D IH+T + D CDTF FP N++
Sbjct: 123 IYKDVIDLKIVDKIHMTFVSNQHDPGAFDNCDTF---------------FPFTVNDL--- 164
Query: 234 FATYVRVRVSAVESHGQDNGLSSDNSYIKFEVK-KFSFLPKMVFERHEEFLYLRLVQDII 292
+ N + S SY+ E S+ HEE+ YL+L+ ++
Sbjct: 165 ----------------ESNFIKSKTSYVTKEAHLTCSYHTYKATVIHEEYQYLQLISKVL 208
Query: 293 SDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVL 352
G + DRTGTGT+S FG MRFNL FPLLTTK+ +W+G+VEELLWFI GSTN L
Sbjct: 209 EHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWFIRGSTNANEL 268
Query: 353 QEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQL 412
K + IWDGN SRD+LD +GL D EEGDLGPVYGFQWRHFGA Y MH Y QG DQL
Sbjct: 269 AAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHDSYDSQGTDQL 328
Query: 413 LDVI 416
+VI
Sbjct: 329 QNVI 332
>Q95US9_PLAGA (tr|Q95US9) Dihydrofolate reductase/thymidylate synthase
OS=Plasmodium gallinaceum GN=DHFR/TS PE=4 SV=1
Length = 589
Score = 243 bits (620), Expect = 3e-62, Method: Compositional matrix adjust.
Identities = 144/409 (35%), Positives = 201/409 (49%), Gaps = 71/409 (17%)
Query: 74 GIGKEGKLPWRL-PSDLKFFKDVTLTTSDSGRK--------------------------- 105
GIG +G LPW+ P D+K+F VT ++S K
Sbjct: 38 GIGNKGVLPWKSNPLDMKYFTTVTTYVNESKYKKLKYKREKYLEKTKDTKCLESIIQLSN 97
Query: 106 ---NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXX 162
N V+MGR +WESIP RPL R+NVVL+RS + + ++I
Sbjct: 98 NLQNVVVMGRTSWESIPERFRPLVNRINVVLSRSLKKEDIKGDAILINNVDDLLLLLRKI 157
Query: 163 XPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSS 222
Y K FIIGG + E L I+ T I ++ +CD F P+I + F+ S
Sbjct: 158 NYY-----KCFIIGGSVVYNEFLKRNLIKKIYFTRINSTYECDVFFPEIKETEFEIMSLS 212
Query: 223 FPIVENNVRYCFATYVRVRV-----SAVESH----------------GQD--NGLSSDNS 259
N F Y R + + +E++ G+D + D+
Sbjct: 213 DVYSNNGATLDFVIYKRKKEILNNENPIENNKEADICSQDSPNNYFTGEDVYKNMDDDDD 272
Query: 260 YIKFEVKK------------FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTL 307
Y+ F F + ++ H E+ YL ++ D+I +GN + DRTG G +
Sbjct: 273 YVYFNFNNTKEKKNSEISDDFKIYNSLKYKYHPEYQYLNIIYDVIMNGNKQGDRTGVGVV 332
Query: 308 SKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRD 367
SKFG M+FNL + FPLLTTKK+F RG++EELLWFI G TN L K + IW+ N +R+
Sbjct: 333 SKFGYMMKFNLNQYFPLLTTKKLFIRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTRE 392
Query: 368 YLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
+LD L DRE DLGP+YGFQWRHFGA YT+MH +Y +G DQL ++I
Sbjct: 393 FLDKRKLFDREVNDLGPIYGFQWRHFGAEYTNMHDNYENKGVDQLKNII 441
>Q7RGH7_PLAYO (tr|Q7RGH7) Thymidylate synthase, putative OS=Plasmodium yoelii
yoelii GN=PY04370 PE=4 SV=1
Length = 588
Score = 240 bits (612), Expect = 2e-61, Method: Compositional matrix adjust.
Identities = 142/406 (34%), Positives = 204/406 (50%), Gaps = 64/406 (15%)
Query: 74 GIGKEGKLPWRLP-SDLKFFKDVTLTTSDS-------------GRKN------------- 106
G+G G LPW+ D+ +F VT +++ G+ N
Sbjct: 36 GLGNAGMLPWKYNLVDMNYFSSVTSYVNENNYIRLQWKRDKYMGKNNLKNNAELNNGELN 95
Query: 107 -----AVIMGRKTWESIPLEHRPLPGRLNVVLTRS-GSFDIATAENVVI-CGXXXXXXXX 159
V+MG+++W+SIP + +PL R+N++L+R+ DIA +N G
Sbjct: 96 NNLQNVVVMGKRSWDSIPPKFKPLQNRINIILSRTLKKEDIANEDNKNNENGTVMIIKSV 155
Query: 160 XXXXPYCLSIE--KVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQ 217
P +I+ K FIIGG + +E L+ I+ T I S +CD P+I+ ++F+
Sbjct: 156 DDLFPILKAIKYYKCFIIGGSYVYKEFLDRNLIKKIYFTRINNSYNCDVLFPEINENLFK 215
Query: 218 PWYSSFPIVENNVRYCFATYVRVRVSAVESHG-------------QDNGLSSDNSYIKF- 263
S NN F Y + + + S+ Q+ ++ Y F
Sbjct: 216 ISSISDVYNSNNTTLDFIIYSK-KTEKINSNKEISNDIFLGLCDEQNKNFDDEDDYTYFS 274
Query: 264 -------------EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKF 310
V F + ++ H E+ YL ++ DII GN +DDRTG G LSKF
Sbjct: 275 FNKNKENIKKNSEHVHNFKIYNSIKYKNHPEYQYLNIIYDIIMHGNKQDDRTGVGVLSKF 334
Query: 311 GCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLD 370
G M+FNL + FPLLTTKK+F RG++EELLWFI G TN L EK + IW+ N +R++LD
Sbjct: 335 GYMMKFNLNQYFPLLTTKKLFVRGIIEELLWFIRGETNGNTLLEKNVRIWEANGTREFLD 394
Query: 371 GIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
L RE DLGP+YGFQWRHFGA YTDMH +Y +G DQL ++I
Sbjct: 395 NRKLFHREVNDLGPIYGFQWRHFGAEYTDMHDNYKDKGVDQLKNII 440
>Q4XXZ2_PLACH (tr|Q4XXZ2) Bifunctional dihydrofolate reductase-thymidylate
synthase, putative (Fragment) OS=Plasmodium chabaudi
GN=PC000873.02.0 PE=4 SV=1
Length = 498
Score = 240 bits (612), Expect = 3e-61, Method: Compositional matrix adjust.
Identities = 134/344 (38%), Positives = 182/344 (52%), Gaps = 37/344 (10%)
Query: 105 KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS-GSFDIATAENVVICGXXXXXXXXXXXX 163
+N V+MG+ +WESIP + +PL R+N++L+R+ D+A N VI
Sbjct: 12 QNIVVMGKASWESIPSKFKPLQNRINIILSRTLKKEDLAKEYNNVII-----INSVDDLF 66
Query: 164 PYCLSIE--KVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYS 221
P SI+ K F+IGG + +E L+ I+ T I + CD P I+ +F+
Sbjct: 67 PILKSIKYYKCFVIGGASVYKEFLDRNLIKKIYFTRINNAYTCDVLFPDINEDLFKITSI 126
Query: 222 SFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSS-----------------DNSYIKFE 264
S NN F Y + + E + D ++ D +Y F
Sbjct: 127 SDVYSSNNTTLDFVIYSKTKEIPEEINPNDEIFNNAFLGVCDEKNTNFDDEDDYTYFSFN 186
Query: 265 VKK------------FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC 312
K F + ++ H E+ YL ++ DII GN +DDRTG G LSKFG
Sbjct: 187 KHKDNIKKNSEHAHHFKIYNSIKYKHHPEYQYLNIIYDIIMHGNKQDDRTGVGVLSKFGY 246
Query: 313 QMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGI 372
M+FNL FPLLTTKK+F RG++EELLWFI G TN L EK + IW+ N +R++LD
Sbjct: 247 MMKFNLSEYFPLLTTKKLFVRGIIEELLWFIRGETNGNTLLEKNVRIWEANGTREFLDNR 306
Query: 373 GLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
L RE DLGP+YGFQWRHFGA YTDMHADY +G DQL ++I
Sbjct: 307 KLFHREVNDLGPIYGFQWRHFGAEYTDMHADYKDKGVDQLKNII 350
>B6AE97_CRYMR (tr|B6AE97) Thymidylate synthase family protein OS=Cryptosporidium
muris (strain RN66) GN=CMU_010300 PE=4 SV=1
Length = 549
Score = 237 bits (605), Expect = 2e-60, Method: Compositional matrix adjust.
Identities = 141/383 (36%), Positives = 205/383 (53%), Gaps = 38/383 (9%)
Query: 65 VVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRK----------NAVIMGRKT 114
+V A+T++ GIGK LPW + DLKFF+++T +T + + NA+I+GRKT
Sbjct: 25 IVAASTKEKGIGKGNNLPWSIKEDLKFFREITCSTIEQSQDDKENTKIEKVNAIILGRKT 84
Query: 115 WESIPLEHRPLPGRLNVVLTRS-GSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVF 173
W+S ++ PL R +VL+R+ D V I +SI K+
Sbjct: 85 WDS--MKRIPLKNRKVIVLSRTLQRCDNKNDSGVSIVKSLDEAINLCNND---ISIHKIV 139
Query: 174 IIGGGQILRESLNAPGCDAIHITEIETSI-DCDTFIPKIDSSVFQPWYSSFPIVENNVRY 232
I GG I RE + + I++T + TS + DT+ P I S F P S N++ Y
Sbjct: 140 ICGGESIYRECIEKNIVETIYLTRVSTSKKEFDTYFPNIPES-FVPILMSQTFCCNDISY 198
Query: 233 CFATYVRVRVSAVESHGQDNGLSSDNSYIKFE--------VKKFSF-----------LPK 273
F Y + ++ + ++ S+ I FE +K S P
Sbjct: 199 DFMIYENEILKPIKRNIRNTSCESE-VIIPFENVLDKIFGERKISLRNKVPKDDIISYPS 257
Query: 274 MVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWR 333
++ H EF YL ++ +++ +G+ +++RTG T S FG MRF+LR +FPLLTTK V R
Sbjct: 258 IIIRDHPEFQYLDMLSNVLQNGHYRENRTGINTYSIFGASMRFDLRESFPLLTTKNVALR 317
Query: 334 GVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHF 393
+ EEL+WFI G TN L +K + IW GN S++YL+ +GL REE DLGP+YGFQWRHF
Sbjct: 318 IIFEELMWFIKGDTNGNHLLDKKVFIWAGNGSKEYLNKVGLGYREENDLGPIYGFQWRHF 377
Query: 394 GARYTDMHADYTGQGFDQLLDVI 416
A Y MH +Y GQG DQL ++I
Sbjct: 378 NAEYKTMHDNYNGQGVDQLANLI 400
>Q4U9G5_THEAN (tr|Q4U9G5) Bifunctional dihydrofolate reductase/thymidilate
synthase, putative OS=Theileria annulata GN=TA08775 PE=4
SV=1
Length = 523
Score = 236 bits (602), Expect = 4e-60, Method: Compositional matrix adjust.
Identities = 140/373 (37%), Positives = 204/373 (54%), Gaps = 29/373 (7%)
Query: 64 QVVVAATRDMGIGKEGKLPW-RLPSDLKF------FKDVTLTTSDSGRKNAVIMGRKTWE 116
+++VA T + GIG + LPW + D F + D G +N +I+GR T++
Sbjct: 12 KILVAITPENGIGIKNGLPWPHIKRDFLFMFRATTYVDPEFKEKHPGAENVIIIGRNTYD 71
Query: 117 SIPLEHRPLPGRLNVVLTRS-----GSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEK 171
S+P PL R+N+V++R+ G ++ + + + + I
Sbjct: 72 SLPESVFPLKNRINIVISRNLTEVPGGLVFSSIPSAI----RHVTENLNYYKIFIMGIFN 127
Query: 172 VFII---GGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKI-DSSVFQPWYSSFPIVE 227
V ++ GG + RE LNA D +++T + + +C+ F PKI D V +F
Sbjct: 128 VVVLKYLGGSHVYREVLNAKIVDKMYVTRVNKNYECEVFFPKIPDDFVITGISKTFS--S 185
Query: 228 NNVRYCFATYVRVRV--SAVESHGQDNGLSSDNSYIKFEVKK--FSFLPKMVFERHEEFL 283
+ Y F Y R + E + L + KF VK+ P++ +E
Sbjct: 186 EDTSYDFVLYERKDLIEEMKEKKTFEQMLLTGE---KFAVKEPLVKACPRLKVRYSQELQ 242
Query: 284 YLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFI 343
YL ++ DI+++G K +RTG ++KFG QMRF+L ++FPLLTTKKVF RG++EEL+WFI
Sbjct: 243 YLEILADILNNGYHKKNRTGVDCIAKFGYQMRFDLSQSFPLLTTKKVFLRGIIEELIWFI 302
Query: 344 SGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHAD 403
GSTN L +K + IW+ N +R +LD +G DREE DLGPVYGFQWRHFGA+Y DMHAD
Sbjct: 303 RGSTNGNELLKKNVRIWELNGARSFLDNLGFYDREEQDLGPVYGFQWRHFGAKYIDMHAD 362
Query: 404 YTGQGFDQLLDVI 416
YT QG DQL VI
Sbjct: 363 YTDQGIDQLSLVI 375
>Q4YWH2_PLABE (tr|Q4YWH2) Bifunctional dihydrofolate reductase-thymidylate
synthase, putative OS=Plasmodium berghei
GN=PB000415.02.0 PE=4 SV=1
Length = 585
Score = 233 bits (595), Expect = 3e-59, Method: Compositional matrix adjust.
Identities = 141/404 (34%), Positives = 198/404 (49%), Gaps = 63/404 (15%)
Query: 74 GIGKEGKLPWRLP-SDLKFFKDVT---------------------------------LTT 99
GIG G LPW+ D+K+F VT + +
Sbjct: 36 GIGNAGVLPWKCNLIDMKYFSSVTSYINENNYIRLKWKRDKYMEKHNLKNNVELNTNIIS 95
Query: 100 SDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXX 159
S + +N V+MG+K+WESIP + +PL R+N++L+R+ + EN
Sbjct: 96 STNNLQNIVVMGKKSWESIPKKFKPLQNRINIILSRTLKKEDIVNENNNENNNVIIIKSV 155
Query: 160 XXXXPY--CLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQ 217
P C K FIIGG + +E L+ I+ T I S +CD P+I+ ++F+
Sbjct: 156 DDLFPILKCTKYYKCFIIGGSSVYKEFLDRNLIKKIYFTRINNSYNCDVLFPEINENLFK 215
Query: 218 PWYSSFPIVENNVRYCFATYVRVR-VSAVES----------HGQDNGLSSDNSYIKF--- 263
S NN F Y + + ++ E Q+ ++ Y F
Sbjct: 216 ITSISDVYNSNNTTLDFIIYSKTKEINPNEEVPNNTFLGVCDEQNKAFDDEDDYTYFSFN 275
Query: 264 -----------EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC 312
F + ++ H E+ YL ++ D+I GN +DDRTG G LSKFG
Sbjct: 276 KNKENIKKNSEHAHNFKIYNSIKYKNHHEYQYLNIIYDMIMHGNNQDDRTG-GVLSKFGY 334
Query: 313 QMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGI 372
M+FNL FPLLTTKK+F RG++EELLWFI G TN L EK + IW+ N +R++LD
Sbjct: 335 MMKFNLNEYFPLLTTKKLFIRGIIEELLWFIRGETNGNTLLEKNVRIWEANGTREFLDR- 393
Query: 373 GLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
L RE DLGP+YGFQWRHFGA YTDMH +Y +G DQL ++I
Sbjct: 394 KLFHREVNDLGPIYGFQWRHFGAEYTDMHDNYKDKGVDQLKNII 437
>Q4N262_THEPA (tr|Q4N262) Dihydrofolate reductase-thymidylate synthase, putative
OS=Theileria parva GN=TP04_0504 PE=4 SV=1
Length = 522
Score = 229 bits (585), Expect = 4e-58, Method: Compositional matrix adjust.
Identities = 139/374 (37%), Positives = 202/374 (54%), Gaps = 32/374 (8%)
Query: 64 QVVVAATRDMGIGKEGKLPW-RLPSDLKF------FKDVTLTTSDSGRKNAVIMGRKTWE 116
+++VA T + GIG LPW + D F + D G +N +I+GRKT++
Sbjct: 12 KLLVAITPENGIGISNGLPWPHIKRDFLFMFRATTYVDPEFKEKHPGAQNVIIIGRKTYD 71
Query: 117 SIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFI-- 174
S+P PL R+NVV++R+ + +V L+ K+FI
Sbjct: 72 SLPEGTFPLKNRINVVISRNLT---EVPGGLVFPSMPAAIRHVTEH----LNYYKIFIMG 124
Query: 175 --------IGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKI-DSSVFQPWYSSFPI 225
+GG + R++L+A D +++T + + C+ F PKI D V +F
Sbjct: 125 IFHLNIKHLGGSYVYRDALDARIVDKMYVTRVNKNYKCEVFFPKIPDDFVITGISKTFS- 183
Query: 226 VENNVRYCFATYVRVRV---SAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEF 282
+ Y F TY R + V+ ++ L+ + K ++ K P + +E
Sbjct: 184 -SEDTTYDFVTYERKDLIVDDRVKKTFEEMLLTGEKFATKDQLVKAC--PSLKVRYSQEL 240
Query: 283 LYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWF 342
YL ++ DI++ G K +RTG ++KFG QMRF+L +FPLLTTKKVF RG++EEL+WF
Sbjct: 241 QYLEILADILNTGYHKKNRTGVDCIAKFGYQMRFDLSESFPLLTTKKVFLRGIIEELIWF 300
Query: 343 ISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHA 402
I GSTN L +K + IW+ N +R +LD +G DREE DLGPVYGFQWRHFGA+Y DMH
Sbjct: 301 IKGSTNGNELLKKNVRIWELNGARSFLDNLGFFDREEHDLGPVYGFQWRHFGAKYVDMHT 360
Query: 403 DYTGQGFDQLLDVI 416
DY+ QG DQL VI
Sbjct: 361 DYSNQGIDQLSLVI 374
>D3VZW1_9APIC (tr|D3VZW1) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium billbrayi GN=DHFR-TS PE=4 SV=1
Length = 608
Score = 228 bits (580), Expect = 1e-57, Method: Compositional matrix adjust.
Identities = 144/428 (33%), Positives = 201/428 (46%), Gaps = 91/428 (21%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR---------------------------- 104
G+G +G LPW+ S D+K+F VT ++S
Sbjct: 39 GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETLNNVMDMPNSKKL 98
Query: 105 KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXP 164
+N V+MGR +WESIP + +PL R+NV+L+R+ + E+V I
Sbjct: 99 QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKE-DIDEDVYIINKVEDLIVLLGKLN 157
Query: 165 YCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFP 224
Y K FIIGG + +E L I+ T I +S +CD F P+I+ + +Q S
Sbjct: 158 Y----YKCFIIGGSVVYKEFLEKKLIKKIYFTRINSSYECDVFFPEINENEYQIISVSDV 213
Query: 225 IVENNVRYCFATYVRVRVSAV--------ESHGQDNGLSSDNSYIKFEVKKFSFLPKMV- 275
NN F Y + + E D L +D+ + +KK + K V
Sbjct: 214 YTSNNTTLDFVIYKKKNNQVLNEKDCIKGEEENNDMSLKNDDK-VTCHMKKLTEFYKNVD 272
Query: 276 -----FER------------------------------------------HEEFLYLRLV 288
+E H E+ YL ++
Sbjct: 273 KYKINYENDDDDEEEDDFVYFNFNKEKEEKNKNCVHPNDFKIYNSLKHKCHPEYQYLNII 332
Query: 289 QDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTN 348
DII +GN + DRTG G LSKFG M+F+L + FPLLTTKK+F RG++EELLWFI G TN
Sbjct: 333 YDIIMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETN 392
Query: 349 CKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQG 408
L K + IW+ N +R++LD L RE DLGP+YGFQWRHFGA YT+MH +Y +G
Sbjct: 393 GNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHDNYENKG 452
Query: 409 FDQLLDVI 416
DQL ++I
Sbjct: 453 VDQLKNII 460
>D3VZW0_9APIC (tr|D3VZW0) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium billcollinsi GN=DHFR-TS PE=4 SV=1
Length = 607
Score = 226 bits (577), Expect = 3e-57, Method: Compositional matrix adjust.
Identities = 143/430 (33%), Positives = 202/430 (46%), Gaps = 96/430 (22%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR---------------------------- 104
GIG +G LPW+ S D+K+F VT + S
Sbjct: 39 GIGNKGVLPWKCNSLDMKYFCAVTTYVNASKYEKLKYKRCKYLNKETLDNVIDMPNSKKL 98
Query: 105 KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS---GSFDIATAENVVICGXXXXXXXXXX 161
+N V+MGR +WESIP + +PL R+NV+L+R+ FD E+V I
Sbjct: 99 QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKIEDLIVLLG 154
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYS 221
L+ K FIIGG + +E L ++ T I ++ +CD F P+I+ + +Q
Sbjct: 155 K----LNYYKCFIIGGSVVYKEFLEKKLIKKVYFTRINSTYECDVFFPEINENEYQIISV 210
Query: 222 SFPIVENNVRYCFATYVRVRVSAV--------ESHGQDNGLSSDNSYIKFEVKKFSFLPK 273
S NN F Y + + E D L +D+ + +KK + K
Sbjct: 211 SDVYTSNNTTLDFIIYKKKNNKLLNEQDCIKGEEKNNDMSLKNDDK-DTYNMKKLTDFYK 269
Query: 274 MV-----------------------------------------------FERHEEFLYLR 286
V ++ H E+ YL
Sbjct: 270 NVDKYKINYEDDDDDEEDDFVYFNFNKEKEEKNKNSVHPNDFQIYNSLKYKYHPEYQYLN 329
Query: 287 LVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGS 346
++ DI+ +GN + DRTG G LSKFG M+F+L + FPLLTTKK+F RG++EELLWFI G
Sbjct: 330 IIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGE 389
Query: 347 TNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTG 406
TN L K + IW+ N +RD+LD L RE DLGP+YGFQWRHFGA YT+MH +Y
Sbjct: 390 TNGNTLLNKNVRIWEANGTRDFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHDNYEN 449
Query: 407 QGFDQLLDVI 416
+G DQL +++
Sbjct: 450 KGVDQLKNIV 459
>D3VZW2_9APIC (tr|D3VZW2) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium billbrayi GN=DHFR-TS PE=4 SV=1
Length = 599
Score = 226 bits (576), Expect = 4e-57, Method: Compositional matrix adjust.
Identities = 145/431 (33%), Positives = 203/431 (47%), Gaps = 97/431 (22%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR---------------------------- 104
G+G +G LPW+ S D+K+F VT ++S
Sbjct: 31 GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 90
Query: 105 KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS---GSFDIATAENVVICGXXXXXXXXXX 161
+N V+MGR +WESIP + +PL R+NV+L+R+ FD E+V I
Sbjct: 91 QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLL- 145
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYS 221
+ L+ K FIIGG + +E L I+ T I ++ +CD F P I+ + +Q
Sbjct: 146 ---WKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPAINENEYQIISX 202
Query: 222 SFPIVENNVRYCFATYVRVRVSAV--------ESHGQDNGLSSDNSYIKFEVKKFSFLPK 273
S NN F Y + + E D L +D+ + +KK + K
Sbjct: 203 SDVYTSNNTTLDFVIYKKKNNQVLNEKDCIKGEEENNDMSLKNDDK-VTCHMKKLTEFYK 261
Query: 274 MV------FER------------------------------------------HEEFLYL 285
V +E H E+ YL
Sbjct: 262 NVDKYKINYENDDDDEEEDDFVYFNFNKEKEEKNKNCVHPNDFKIYNSLKHKCHPEYQYL 321
Query: 286 RLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISG 345
++ DII +GN + DRTG G LSKFG M+F+L + FPLLTTKK+F RG++EELLWFI G
Sbjct: 322 NIIYDIIMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRG 381
Query: 346 STNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYT 405
TN L K + IW+ N +R++LD L RE DLGP+YGFQWRHFGA YT+MH +Y
Sbjct: 382 ETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHDNYE 441
Query: 406 GQGFDQLLDVI 416
+G DQL ++I
Sbjct: 442 NKGVDQLKNII 452
>D2W4C0_NAEGR (tr|D2W4C0) Predicted protein OS=Naegleria gruberi
GN=NAEGRDRAFT_76251 PE=4 SV=1
Length = 535
Score = 225 bits (574), Expect = 6e-57, Method: Compositional matrix adjust.
Identities = 153/400 (38%), Positives = 202/400 (50%), Gaps = 82/400 (20%)
Query: 65 VVVAATRDMGIGKEGKLPWR---LPSDLKFFKDVTLTT------SDSGRK---------- 105
VV GIG G LPW L D+K F VT ++ S S K
Sbjct: 20 VVAVLLNSNGIGLNGNLPWLQDGLTEDMKHFVSVTCSSEPLKFISPSMYKQSSSSSPITS 79
Query: 106 ---------------NAVIMGRKTWESIPLEHRPLPGRLNVVL--TRSGSFDIATAENVV 148
NAVIMGRKTWESIP + +PL + ++ ++ D E
Sbjct: 80 DNTNDNTTTINDQLMNAVIMGRKTWESIPSKFKPLSKNRHAIILSSKVNDDDQLMMERTT 139
Query: 149 ICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEI----ETSIDC 204
+ ++FI GG I + L P IH T I +I
Sbjct: 140 FVKNVDELFELLQNQKF----NRIFIAGGTSIYK--LLLPYTAVIHYTNIIEQKGVNIQV 193
Query: 205 DT-----FIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
DT +P D Y + PI N ++ V S D L +N
Sbjct: 194 DTRFPIRLLPSSD-------YRNVPINSNQ-------FIAVDKS-------DKILPKNNE 232
Query: 260 YIKFEVKKFSFLPKMVFER-HEEFLYLRLVQDII-SDGNLKDDRTGTGTLSKFGCQMRFN 317
+ + F+ FER HEEF YL +++++I SD N++++RTG GT+SKFG QM+++
Sbjct: 233 ----RISHYEFI---TFERRHEEFQYLDIIKELILSDINVREERTGVGTVSKFGYQMKYS 285
Query: 318 LRRT-FPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKD 376
LR FPLLTTK+VFW+GV +EL WFISGSTN K+L E+ IHIWDGN SR+YLD +G ++
Sbjct: 286 LRNNVFPLLTTKRVFWKGVAKELFWFISGSTNAKILSEQDIHIWDGNGSREYLDSLGFEN 345
Query: 377 REEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
REE DLGPVYGFQWRH+G+ Y +MH DYT +G DQL I
Sbjct: 346 REEMDLGPVYGFQWRHWGSSYENMHTDYTNKGVDQLKKCI 385
>D3VZV9_PLARE (tr|D3VZV9) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium reichenowi GN=DHFR-TS PE=4 SV=1
Length = 598
Score = 224 bits (571), Expect = 2e-56, Method: Compositional matrix adjust.
Identities = 141/428 (32%), Positives = 200/428 (46%), Gaps = 93/428 (21%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR---------------------------- 104
G+G +G LPW+ S D+K+F VT ++S
Sbjct: 31 GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLKKETVDNVNDMPNSKKL 90
Query: 105 KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS---GSFDIATAENVVICGXXXXXXXXXX 161
+N V+MGR +WESIP + +PL R+NV+L+R+ FD E+V I
Sbjct: 91 QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 146
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYS 221
L+ K FIIGG + +E L I+ T I ++ +CD F P I+ + +Q
Sbjct: 147 K----LNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPAINENEYQIISV 202
Query: 222 SFPIVENNVRYCFATYVRVRVSAV--------ESHGQDNGLSSDNS-------------- 259
S NN F Y + + E D L +D+
Sbjct: 203 SDVYTSNNTTLDFIIYQKKNNKVLNEQDCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKN 262
Query: 260 ----YIKFE---------------------------VKKFSFLPKMVFERHEEFLYLRLV 288
I +E F + ++ H E+ YL ++
Sbjct: 263 VDKYKINYENDDDGEDDFVYFNFNKEKEEKNKNSVHANDFQIYNSLKYKYHPEYQYLNII 322
Query: 289 QDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTN 348
DI+ +GN + DRTG G LSKFG M+F+L + FPLLTTKK+F RG++EELLWFI G TN
Sbjct: 323 YDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETN 382
Query: 349 CKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQG 408
L K + IW+ N +R++LD L RE DLGP+YGFQWRHFGA YT+M+ +Y +G
Sbjct: 383 GNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKG 442
Query: 409 FDQLLDVI 416
DQL ++I
Sbjct: 443 VDQLKNII 450
>Q06BX0_9CILI (tr|Q06BX0) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Paramecium biaurelia PE=4 SV=1
Length = 369
Score = 223 bits (567), Expect = 5e-56, Method: Compositional matrix adjust.
Identities = 115/252 (45%), Positives = 151/252 (59%), Gaps = 27/252 (10%)
Query: 165 YCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFP 224
Y S +K+F+IGG +I E L C +H+T I CD ++ K S F+ +S
Sbjct: 14 YNTSNQKMFLIGGKRIFEEGLATDKCSDVHLTRIGVETKCDVYLNKNIFSTFKVNKTSQT 73
Query: 225 IVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLY 284
EN + Y + + N S + SYI E H+E Y
Sbjct: 74 KSENEINYDYQHLI-------------NKNSQEQSYID--------------EEHQENQY 106
Query: 285 LRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFIS 344
L +++ I+ +G KDDRTG GT+S FG MRFNL +FPLLTTKKVF+RGVVEELLWF+
Sbjct: 107 LDMIRKIMKEGVHKDDRTGVGTISIFGQTMRFNLAESFPLLTTKKVFFRGVVEELLWFLR 166
Query: 345 GSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADY 404
G TN K+L +KG+ IW+GN +R+YLD IGL +R+E DLGPVYG+QWRHFGA Y D +DY
Sbjct: 167 GDTNGKILLDKGVKIWEGNGTREYLDSIGLSNRQEHDLGPVYGYQWRHFGAEYKDCQSDY 226
Query: 405 TGQGFDQLLDVI 416
QG DQ+ +VI
Sbjct: 227 NNQGVDQVKEVI 238
>Q8MVZ6_9EUGL (tr|Q8MVZ6) Bifunctional dihydrofolate reductase-thymidylate
synthase (Fragment) OS=Diplonema ambulator GN=DHFR-TS
PE=4 SV=1
Length = 255
Score = 222 bits (566), Expect = 6e-56, Method: Compositional matrix adjust.
Identities = 128/293 (43%), Positives = 164/293 (55%), Gaps = 44/293 (15%)
Query: 109 IMGRKTWESIPLEHRPLPGRLNVVLTRS-GSFDIATAENVVIC-GXXXXXXXXXXXXPYC 166
+MG KTWESIP + RPL GRLN+VL+R D+ +NVV+ G Y
Sbjct: 1 VMGSKTWESIPEKFRPLEGRLNIVLSRDMKQEDVKGLDNVVVVNGGLTDALTLLGEKEYL 60
Query: 167 LSIEKVFIIGGGQILRESLNAPGCDAIH---ITEIETSIDCDTFIPKIDSSVFQPWYSSF 223
+++VF+IGGG + E+L AP +H +T++E DCDTF+ F+
Sbjct: 61 AKVDRVFVIGGGSLYNEALAAPCLPILHNVYLTQVEGEFDCDTFVAFTPGKSFR------ 114
Query: 224 PIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFL 283
VS E+ ++ IK + +S + K EE
Sbjct: 115 -----------------EVSKSEAEDKN---------IKMTMYHYSKVNK------EEQQ 142
Query: 284 YLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEELLWF 342
YL LV DII +G K DRTG GT+SKFG QMRF+LR PLLTTK+VFW+GV EEL WF
Sbjct: 143 YLDLVDDIIKNGFTKGDRTGVGTISKFGAQMRFSLRDGVIPLLTTKRVFWKGVAEELFWF 202
Query: 343 ISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGA 395
I G TN K L++KG+HIWDGN +R +LD GL DR E DLGP+YG QW HFGA
Sbjct: 203 IKGCTNGKDLKDKGVHIWDGNGTRAFLDSRGLPDRAEDDLGPIYGLQWSHFGA 255
>Q06BX2_9CILI (tr|Q06BX2) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Paramecium biaurelia PE=4 SV=1
Length = 369
Score = 221 bits (563), Expect = 1e-55, Method: Compositional matrix adjust.
Identities = 114/252 (45%), Positives = 150/252 (59%), Gaps = 27/252 (10%)
Query: 165 YCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFP 224
Y S +K+F+IGG +I E L C +H+T I CD ++ K S F+ +S
Sbjct: 14 YNTSNQKMFLIGGKRIFEEGLATDKCSDVHLTRIGVETKCDVYLNKNIFSTFKVNKTSQT 73
Query: 225 IVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLY 284
EN + Y + + N S + SYI E H+E Y
Sbjct: 74 KSENEINYDYQHLI-------------NKNSQEQSYID--------------EEHQENQY 106
Query: 285 LRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFIS 344
L +++ I+ +G KDDRTG GT+S FG MRFNL +FPLLTTKKVF+RG VEELLWF+
Sbjct: 107 LDMIRKIMKEGVHKDDRTGVGTISIFGQTMRFNLAESFPLLTTKKVFFRGAVEELLWFLR 166
Query: 345 GSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADY 404
G TN K+L +KG+ IW+GN +R+YLD IGL +R+E DLGPVYG+QWRHFGA Y D +DY
Sbjct: 167 GDTNGKILLDKGVKIWEGNGTREYLDSIGLSNRQEHDLGPVYGYQWRHFGAEYKDCQSDY 226
Query: 405 TGQGFDQLLDVI 416
QG DQ+ +VI
Sbjct: 227 NNQGVDQVKEVI 238
>Q8MVZ8_9EUKA (tr|Q8MVZ8) Bifunctional dihydrofolate reductase-thymidylate
synthase (Fragment) OS=Chlamydaster sterni GN=DHFR-TS
PE=4 SV=1
Length = 260
Score = 220 bits (560), Expect = 3e-55, Method: Compositional matrix adjust.
Identities = 129/290 (44%), Positives = 165/290 (56%), Gaps = 33/290 (11%)
Query: 109 IMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLS 168
+MGRKTWESIP ++RPL RLNVV++R+ + +V+ P
Sbjct: 1 VMGRKTWESIPKKYRPLKDRLNVVISRTPTAISDLPASVLAFDCLEQALQIVDNIPV--- 57
Query: 169 IEKVFIIGGGQILRESLNAPGCDAIHITEIE-TSIDCDTFIPKIDSSVFQPWYSSFPIVE 227
I+ V+I+GGGQI E++ P C I +T + S +CDTF P++ + P E
Sbjct: 58 IQDVYIVGGGQIYNEAIVHPRCTRIFLTHVRGISPECDTFFPELKGWKLDKESGNVPDPE 117
Query: 228 N-NVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLR 286
V F YVR ++ + +D++ + E K+ YL
Sbjct: 118 APEVELNFCEYVR-----------ESPVLNDDTLVNAEEKQ----------------YLD 150
Query: 287 LVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEELLWFISG 345
LV II+ G + DRTGTGTLS FG QMRF+ R T PLLTTKKVFWRGV EE+LWF+ G
Sbjct: 151 LVDRIITSGTQRGDRTGTGTLSIFGTQMRFSPRDDTLPLLTTKKVFWRGVAEEMLWFMKG 210
Query: 346 STNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGA 395
T+ +VL K IHIWD NASR +LD GL REEGDLGPVYGFQWRHFGA
Sbjct: 211 CTDARVLSAKKIHIWDDNASRKFLDENGLSHREEGDLGPVYGFQWRHFGA 260
>Q8LL90_9STRA (tr|Q8LL90) Bifunctional dihydrofolate reductase-thymidylate
synthase (Fragment) OS=cf. 'Cafeteria' marsupialis
'Wood's Hole' GN=DHFR-TS PE=4 SV=1
Length = 268
Score = 218 bits (556), Expect = 9e-55, Method: Compositional matrix adjust.
Identities = 123/297 (41%), Positives = 176/297 (59%), Gaps = 39/297 (13%)
Query: 109 IMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXX--XXXPYC 166
+MGRKTWESIP + RPL R+NVV++ S ++++A N++ +
Sbjct: 1 VMGRKTWESIPRQRRPLSNRINVVVSSSIDNELSSA-NILTAKSLNDALSSLFDHVDQHN 59
Query: 167 LSIEKVFIIGGGQILRESLNAPGCDAIHITEIETS--IDCDTFIPKIDSSVFQP-----W 219
+++ K+F+IGG ++ +E+L + C++I++TEI + D D F P I ++ + W
Sbjct: 60 INVGKIFVIGGERLFKEALASTACESIYLTEIRSPELRDFDVFFPAIPANEYALTERGCW 119
Query: 220 YSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERH 279
S + + Y F + R+ +D+ +++ + +
Sbjct: 120 KKS----GDYLSYRFCEFRRI---------------ADDRFVEVNPQVGNV--------- 151
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR-RTFPLLTTKKVFWRGVVEE 338
EE YL ++DI+ +G + DRTGTGTLSKFG MRF+LR T PL+TTKKVFWRGVVEE
Sbjct: 152 EEMQYLNAIRDILDNGVDRSDRTGTGTLSKFGLHMRFSLRDNTLPLITTKKVFWRGVVEE 211
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGA 395
LLWF+ G T+ K+L KG+HIWDGN SR+YLD GL EEGDLGPVYGFQW HFGA
Sbjct: 212 LLWFVRGFTDSKLLSAKGVHIWDGNGSREYLDSRGLFHNEEGDLGPVYGFQWSHFGA 268
>Q06BX1_9CILI (tr|Q06BX1) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Paramecium biaurelia PE=4 SV=1
Length = 369
Score = 215 bits (547), Expect = 9e-54, Method: Compositional matrix adjust.
Identities = 113/252 (44%), Positives = 148/252 (58%), Gaps = 27/252 (10%)
Query: 165 YCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFP 224
Y S +K+F+ GG I E L C +H+T I CD ++ K S F+ +S
Sbjct: 14 YNTSNQKMFLTGGKGIFEEGLATDKCSDVHLTRIGVETKCDVYLNKNIFSTFKVNKTSQT 73
Query: 225 IVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLY 284
EN + Y + + N S + SYI E H+E Y
Sbjct: 74 KSENEINYDYQHLI-------------NKNSQEQSYID--------------EEHQENQY 106
Query: 285 LRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFIS 344
L +++ I+ +G KDDRTG GT+S FG MRFNL +FPLLTTKKVF+RGVVEELL F+
Sbjct: 107 LDMIRKIMKEGVHKDDRTGVGTISIFGQTMRFNLAESFPLLTTKKVFFRGVVEELLRFLR 166
Query: 345 GSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADY 404
G TN K+L +KG+ IW+GN +R+YLD IGL +R+E DLGPVYG+QWRHFGA Y D +DY
Sbjct: 167 GDTNGKILLDKGVKIWEGNGTREYLDSIGLSNRQEHDLGPVYGYQWRHFGAEYKDCQSDY 226
Query: 405 TGQGFDQLLDVI 416
QG DQ+ +VI
Sbjct: 227 NNQGVDQVKEVI 238
>C6GJB8_LITVA (tr|C6GJB8) Thymidylate synthase OS=Litopenaeus vannamei GN=TS PE=2
SV=1
Length = 289
Score = 212 bits (540), Expect = 5e-53, Method: Compositional matrix adjust.
Identities = 98/140 (70%), Positives = 114/140 (81%), Gaps = 1/140 (0%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVV 336
RH+E+ YL L++ I+ GN K DRTGTGT+S FG QMR++LR FPLLTTK+VFWRGV
Sbjct: 2 RHDEYQYLDLIRQIMRTGNRKGDRTGTGTISMFGAQMRYSLRDGIFPLLTTKRVFWRGVA 61
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWF+ GSTN K LQEK IHIWDGN+S+++L+ +G DREEGDLGPVYGFQWRHFGA
Sbjct: 62 EELLWFVRGSTNAKELQEKDIHIWDGNSSKEFLNKMGFHDREEGDLGPVYGFQWRHFGAP 121
Query: 397 YTDMHADYTGQGFDQLLDVI 416
Y DMH DYTGQG DQL VI
Sbjct: 122 YADMHTDYTGQGVDQLQQVI 141
>B3RLB4_TRIAD (tr|B3RLB4) Thymidylate synthase OS=Trichoplax adhaerens
GN=TRIADDRAFT_18453 PE=3 SV=1
Length = 317
Score = 207 bits (527), Expect = 2e-51, Method: Compositional matrix adjust.
Identities = 94/139 (67%), Positives = 111/139 (79%), Gaps = 1/139 (0%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR-RTFPLLTTKKVFWRGVVE 337
HEE+ YLRL+Q I+++GN K DRTGTGT S FG QMRF+LR PLLTTK+ FWRG+ E
Sbjct: 31 HEEYQYLRLIQRIMNEGNFKGDRTGTGTKSIFGAQMRFSLRDNQMPLLTTKRTFWRGIAE 90
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF+ GSTN L EKGI W+ N SR++LD GL +RE GDLGP+YGFQWRHFGA+Y
Sbjct: 91 ELLWFVKGSTNANQLNEKGIKFWNANGSREFLDSRGLHEREVGDLGPIYGFQWRHFGAKY 150
Query: 398 TDMHADYTGQGFDQLLDVI 416
T+MHADYTGQG DQL +VI
Sbjct: 151 TNMHADYTGQGVDQLAEVI 169
>A7RH38_NEMVE (tr|A7RH38) Thymidylate synthase OS=Nematostella vectensis
GN=v1g227987 PE=3 SV=1
Length = 306
Score = 207 bits (527), Expect = 2e-51, Method: Compositional matrix adjust.
Identities = 100/156 (64%), Positives = 114/156 (73%), Gaps = 1/156 (0%)
Query: 262 KFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR- 320
K V K K +RH+E YL +++ I+ +G +K DRTGTGT S FG QMRF+LR
Sbjct: 3 KDSVSKLKKEAKHSTKRHDELQYLDMIRYIMENGTVKTDRTGTGTKSVFGAQMRFSLRDG 62
Query: 321 TFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEG 380
FPLLTTK+VFWRGV EELLWF+ G TN KVL +K IHIWD N SR +LD GL REEG
Sbjct: 63 VFPLLTTKRVFWRGVAEELLWFVKGCTNAKVLADKNIHIWDANGSRGFLDRQGLSHREEG 122
Query: 381 DLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
DLGPVYGFQWRHFGA+Y DMH DYTGQG DQL VI
Sbjct: 123 DLGPVYGFQWRHFGAKYVDMHTDYTGQGVDQLAQVI 158
>Q6WEA9_9EUKA (tr|Q6WEA9) Thymidylate synthase (Fragment) OS=Corallochytrium
limacisporum PE=3 SV=1
Length = 207
Score = 206 bits (525), Expect = 3e-51, Method: Compositional matrix adjust.
Identities = 97/138 (70%), Positives = 110/138 (79%), Gaps = 1/138 (0%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEE 338
EE YL LV+ II++G+ K DRTGTGTLS FG QMRF+LR FPLLTTK+VFWRGV EE
Sbjct: 39 EERQYLELVEKIINEGSRKGDRTGTGTLSIFGAQMRFSLRDDIFPLLTTKRVFWRGVAEE 98
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF+SG TN K L +K + IWD N SR++LD GL DREEGDLGPVYGFQWRHFGA YT
Sbjct: 99 LLWFVSGDTNAKTLSDKNVKIWDANGSREFLDNRGLTDREEGDLGPVYGFQWRHFGAEYT 158
Query: 399 DMHADYTGQGFDQLLDVI 416
MH DYTG+G DQL +VI
Sbjct: 159 TMHDDYTGKGVDQLAEVI 176
>Q8MVZ5_9HYMN (tr|Q8MVZ5) Bifunctional dihydrofolate reductase-thymidylate
synthase (Fragment) OS=Tetrahymena sp. GN=DHFR-TS PE=4
SV=1
Length = 311
Score = 204 bits (519), Expect = 2e-50, Method: Compositional matrix adjust.
Identities = 125/318 (39%), Positives = 167/318 (52%), Gaps = 38/318 (11%)
Query: 109 IMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLS 168
+MGRKTWES+P +PL R+NVV++ S ++ E V++
Sbjct: 1 MMGRKTWESLPDAFKPLSSRINVVVSSKLSAEM-LPEGVLLSTSLNDAIKKFENTE---E 56
Query: 169 IEKVFIIGGGQILRESLNAPGCDAIHITEIETSID-CDTFIPKIDSSV--------FQPW 219
+ ++F+IGG ++ +E++ + D + +T + ++D CD F+ ++SSV F P
Sbjct: 57 VHEIFVIGGERLYKEAIESHIVDRVFLTRMAITMDDCDAFLRGMESSVDANDADSSFVPV 116
Query: 220 YSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFL-------- 271
S VEN V Y F Y +V+A + D Y + FS L
Sbjct: 117 AVSPTQVENGVSYDFCVYASRQVAASMKIASEARTRPDELY---DTLGFSLLDPRLRSDS 173
Query: 272 ------PKMV-------FERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNL 318
P V HEEF YL LVQ ++S G + DRTGTGTLS FG MRF+L
Sbjct: 174 NGRKTYPPAVPSICCPKLRSHEEFQYLDLVQRVVSTGVSRGDRTGTGTLSIFGAMMRFDL 233
Query: 319 RR-TFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDR 377
FPLLTTKK F RG+ EEL WF+ G T+ L K +HIWD NA+R +LD GL DR
Sbjct: 234 SSGAFPLLTTKKTFLRGIAEELFWFLKGDTSQTRLAAKDVHIWDANATRAFLDARGLPDR 293
Query: 378 EEGDLGPVYGFQWRHFGA 395
EGDLGPVYG QW HFGA
Sbjct: 294 PEGDLGPVYGCQWSHFGA 311
>Q8MW00_9EUKA (tr|Q8MW00) Bifunctional dihydrofolate reductase-thymidylate
synthase (Fragment) OS=Amastigomonas debruynei
GN=DHFR-TS PE=4 SV=1
Length = 259
Score = 203 bits (516), Expect = 3e-50, Method: Compositional matrix adjust.
Identities = 118/287 (41%), Positives = 161/287 (56%), Gaps = 28/287 (9%)
Query: 109 IMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLS 168
+MGRKTW+SIP RPL R+N+V++R+ + T E V + P
Sbjct: 1 VMGRKTWDSIPQRLRPLKDRVNIVVSRT---MLETPEGVHLARSLDDALLVASLVP---R 54
Query: 169 IEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVEN 228
+ V ++GG Q+ E++ P C + +TE+ T++ ++V W +
Sbjct: 55 VGLVSVLGGFQLFAEAMQDPRCTWVELTEVHTAVREGV---GAGAAVVTNWPGEVDLAAQ 111
Query: 229 NVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLV 288
FA VS E H + S I+FE ++ ++ E YL L+
Sbjct: 112 GF---FA-----EVSRSERH--------EESGIEFEYVRYE---RIRGPNRGELGYLDLI 152
Query: 289 QDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTN 348
+ +++DG +DDRTG GT S FG ++ F+L FPLLTTK+VFWRGV EELLWF+SGSTN
Sbjct: 153 RRVLADGFERDDRTGVGTFSLFGEKLEFDLGDGFPLLTTKRVFWRGVAEELLWFVSGSTN 212
Query: 349 CKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGA 395
L KGI IWDGN+SR+YLD IGL +RE GDLGPVYGFQW HFGA
Sbjct: 213 ANELAAKGIRIWDGNSSREYLDSIGLTEREVGDLGPVYGFQWSHFGA 259
>D2A1S6_TRICA (tr|D2A1S6) Thymidylate synthase OS=Tribolium castaneum
GN=GLEAN_07732 PE=3 SV=1
Length = 330
Score = 200 bits (509), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 96/151 (63%), Positives = 112/151 (74%), Gaps = 3/151 (1%)
Query: 267 KFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR-RTFPLL 325
K S LP + + HEE+ YL ++ II G K DRTG GT S FG QMR++LR FPLL
Sbjct: 34 KTSSLP--LEQEHEEYQYLSHIKLIIDKGVKKSDRTGVGTFSIFGAQMRYSLRDNVFPLL 91
Query: 326 TTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPV 385
TTK+VFWRGVVEELLWFI GSTN L+EK +HIWD N++R++LD +GL +REEGDLGPV
Sbjct: 92 TTKRVFWRGVVEELLWFIKGSTNANELKEKNVHIWDANSTREFLDSVGLNEREEGDLGPV 151
Query: 386 YGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
YGFQWRHFGA Y MH DY QG DQL VI
Sbjct: 152 YGFQWRHFGAEYKGMHWDYANQGIDQLAHVI 182
>C3ZXJ5_BRAFL (tr|C3ZXJ5) Thymidylate synthase OS=Branchiostoma floridae
GN=BRAFLDRAFT_77468 PE=3 SV=1
Length = 294
Score = 200 bits (509), Expect = 3e-49, Method: Compositional matrix adjust.
Identities = 94/146 (64%), Positives = 108/146 (73%)
Query: 271 LPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKV 330
+P +H+E+ YL LV+ I+ G KDDRTGTGTLS FG Q R++LR FPLLTTK+V
Sbjct: 1 MPSRPARKHDEYQYLDLVRHILDCGQRKDDRTGTGTLSVFGAQCRYSLRGQFPLLTTKRV 60
Query: 331 FWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQW 390
FWRGV EELLWF+ G TN K L +K +HIWD N SRD+LD GL EEGDLGPVYGFQW
Sbjct: 61 FWRGVAEELLWFVRGCTNGKELSDKKVHIWDANGSRDFLDKRGLSHYEEGDLGPVYGFQW 120
Query: 391 RHFGARYTDMHADYTGQGFDQLLDVI 416
RHFGA Y D + DYTGQG DQL VI
Sbjct: 121 RHFGAEYKDRYTDYTGQGVDQLAQVI 146
>Q544L2_MOUSE (tr|Q544L2) Thymidylate synthase OS=Mus musculus GN=Tyms PE=2 SV=1
Length = 307
Score = 199 bits (507), Expect = 4e-49, Method: Compositional matrix adjust.
Identities = 93/139 (66%), Positives = 107/139 (76%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVE 337
RH E YLR V+ I+ G K+DRTGTGTLS FG Q R++LR FPLLTTK+VFW+GV+E
Sbjct: 21 RHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLE 80
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWFI GSTN K L KG+ IWD N SRD+LD +G R+EGDLGPVYGFQWRHFGA Y
Sbjct: 81 ELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEY 140
Query: 398 TDMHADYTGQGFDQLLDVI 416
DM +DY+GQG DQL VI
Sbjct: 141 KDMDSDYSGQGVDQLQKVI 159
>Q9D0H1_MOUSE (tr|Q9D0H1) Thymidylate synthase OS=Mus musculus GN=Tyms PE=2 SV=1
Length = 307
Score = 199 bits (507), Expect = 4e-49, Method: Compositional matrix adjust.
Identities = 93/139 (66%), Positives = 107/139 (76%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVE 337
RH E YLR V+ I+ G K+DRTGTGTLS FG Q R++LR FPLLTTK+VFW+GV+E
Sbjct: 21 RHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLE 80
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWFI GSTN K L KG+ IWD N SRD+LD +G R+EGDLGPVYGFQWRHFGA Y
Sbjct: 81 ELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEY 140
Query: 398 TDMHADYTGQGFDQLLDVI 416
DM +DY+GQG DQL VI
Sbjct: 141 KDMDSDYSGQGVDQLQKVI 159
>A8K9A5_HUMAN (tr|A8K9A5) Thymidylate synthase OS=Homo sapiens PE=2 SV=1
Length = 313
Score = 198 bits (504), Expect = 8e-49, Method: Compositional matrix adjust.
Identities = 93/138 (67%), Positives = 105/138 (76%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEE 338
H E YL +Q I+ G KDDRTGTGTLS FG Q R++LR FPLLTTK+VFW+GV+EE
Sbjct: 28 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWFI GSTN K L KG+ IWD N SRD+LD +G REEGDLGPVYGFQWRHFGA Y
Sbjct: 88 LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 147
Query: 399 DMHADYTGQGFDQLLDVI 416
DM +DY+GQG DQL VI
Sbjct: 148 DMESDYSGQGVDQLQRVI 165
>Q53Y97_HUMAN (tr|Q53Y97) Thymidylate synthase OS=Homo sapiens GN=TYMS PE=2 SV=1
Length = 313
Score = 198 bits (504), Expect = 9e-49, Method: Compositional matrix adjust.
Identities = 93/138 (67%), Positives = 105/138 (76%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEE 338
H E YL +Q I+ G KDDRTGTGTLS FG Q R++LR FPLLTTK+VFW+GV+EE
Sbjct: 28 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWFI GSTN K L KG+ IWD N SRD+LD +G REEGDLGPVYGFQWRHFGA Y
Sbjct: 88 LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 147
Query: 399 DMHADYTGQGFDQLLDVI 416
DM +DY+GQG DQL VI
Sbjct: 148 DMESDYSGQGVDQLQRVI 165
>Q53FB7_HUMAN (tr|Q53FB7) Thymidylate synthase (Fragment) OS=Homo sapiens PE=2
SV=1
Length = 313
Score = 198 bits (504), Expect = 9e-49, Method: Compositional matrix adjust.
Identities = 93/138 (67%), Positives = 105/138 (76%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEE 338
H E YL +Q I+ G KDDRTGTGTLS FG Q R++LR FPLLTTK+VFW+GV+EE
Sbjct: 28 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWFI GSTN K L KG+ IWD N SRD+LD +G REEGDLGPVYGFQWRHFGA Y
Sbjct: 88 LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 147
Query: 399 DMHADYTGQGFDQLLDVI 416
DM +DY+GQG DQL VI
Sbjct: 148 DMESDYSGQGVDQLQRVI 165
>Q7QDW7_ANOGA (tr|Q7QDW7) Thymidylate synthase OS=Anopheles gambiae GN=AGAP010457
PE=3 SV=3
Length = 302
Score = 198 bits (504), Expect = 9e-49, Method: Compositional matrix adjust.
Identities = 96/138 (69%), Positives = 109/138 (78%), Gaps = 1/138 (0%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEE 338
EE YL+L++DII+ G+ + DRTG GTLS FG QMRF+LR PLLTTKKVF+RGV EE
Sbjct: 17 EEQAYLQLIRDIINKGSKRLDRTGVGTLSIFGAQMRFSLRDGIIPLLTTKKVFFRGVAEE 76
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWFI GSTN K LQ KG+ IWDGN++R+YLD G DREEGDLGPVYGFQWRHFGA Y
Sbjct: 77 LLWFIKGSTNVKDLQAKGVRIWDGNSTREYLDSCGFTDREEGDLGPVYGFQWRHFGATYK 136
Query: 399 DMHADYTGQGFDQLLDVI 416
H DYTGQG DQL +VI
Sbjct: 137 TCHDDYTGQGIDQLAEVI 154
>A4HSX8_LEIIN (tr|A4HSX8) Thymidylate synthase OS=Leishmania infantum
GN=LinJ06.0890 PE=3 SV=1
Length = 395
Score = 198 bits (503), Expect = 1e-48, Method: Compositional matrix adjust.
Identities = 109/258 (42%), Positives = 149/258 (57%), Gaps = 37/258 (14%)
Query: 164 PYCLSIEKVFIIGGGQILRESLNAPGCDA---IHITEIETSID-CDTFIPKIDSSVFQPW 219
PYC SIE + +GG Q+ +++ +P + +++T I T+ C F P
Sbjct: 20 PYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFP---------- 69
Query: 220 YSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERH 279
FP + A+ S G+ S+ ++FE+ K+ V H
Sbjct: 70 ---FPPENTTTAWDLAS----------SQGRRK---SEADGLEFEICKY------VPRNH 107
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR-RTFPLLTTKKVFWRGVVEE 338
EE YL L+ I+ G +K+DRTG GT+S FG QMRF+LR PLLTTK+VFWRGV EE
Sbjct: 108 EERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEE 167
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF+ G TN ++L +K IHIWDGN SR++LD GL + +E DLGPVYGFQWRHFGA Y
Sbjct: 168 LLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYK 227
Query: 399 DMHADYTGQGFDQLLDVI 416
A+Y G+G DQ+ ++
Sbjct: 228 GFEANYDGEGVDQIRSIV 245
>Q8VDV6_MOUSE (tr|Q8VDV6) Thymidylate synthase OS=Mus musculus GN=Tyms PE=2 SV=1
Length = 307
Score = 198 bits (503), Expect = 1e-48, Method: Compositional matrix adjust.
Identities = 92/139 (66%), Positives = 107/139 (76%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVE 337
+H E YLR V+ I+ G K+DRTGTGTLS FG Q R++LR FPLLTTK+VFW+GV+E
Sbjct: 21 QHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLE 80
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWFI GSTN K L KG+ IWD N SRD+LD +G R+EGDLGPVYGFQWRHFGA Y
Sbjct: 81 ELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEY 140
Query: 398 TDMHADYTGQGFDQLLDVI 416
DM +DY+GQG DQL VI
Sbjct: 141 KDMDSDYSGQGVDQLQKVI 159
>C0H809_SALSA (tr|C0H809) Thymidylate synthase OS=Salmo salar GN=TYSY PE=2 SV=1
Length = 333
Score = 195 bits (496), Expect = 8e-48, Method: Compositional matrix adjust.
Identities = 89/137 (64%), Positives = 105/137 (76%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL + I+ G+ K DRTGTG +S FG Q R++LR FPLLTTK+VFW+G++EEL
Sbjct: 49 DERGYLNQCEYILQHGHRKGDRTGTGVISVFGSQTRYSLRDQFPLLTTKRVFWKGILEEL 108
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWFI GSTN K L EKG+ IWD N SR +LD +G DREEGDLGPVYGFQWRH+GA Y+D
Sbjct: 109 LWFIKGSTNAKELTEKGVRIWDANGSRQFLDKMGFTDREEGDLGPVYGFQWRHYGAEYSD 168
Query: 400 MHADYTGQGFDQLLDVI 416
MH DYTGQG DQL VI
Sbjct: 169 MHKDYTGQGVDQLQKVI 185
>B0WW05_CULQU (tr|B0WW05) Thymidylate synthase OS=Culex quinquefasciatus
GN=CpipJ_CPIJ011359 PE=3 SV=1
Length = 310
Score = 195 bits (496), Expect = 8e-48, Method: Compositional matrix adjust.
Identities = 92/141 (65%), Positives = 108/141 (76%), Gaps = 1/141 (0%)
Query: 277 ERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGV 335
+ +E YL L + II+ GN + DRTG GTLS FG QMR+NLR T PLLTTK+VF+RGV
Sbjct: 22 QNEDEMQYLELTRRIIAKGNKRLDRTGVGTLSIFGSQMRYNLRNNTLPLLTTKRVFFRGV 81
Query: 336 VEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGA 395
EELLWFI G TN K LQ+K IHIWDGN++R++LD G DREEGDLGPVYGFQWRHFGA
Sbjct: 82 AEELLWFIRGRTNAKDLQQKNIHIWDGNSTREFLDSAGFTDREEGDLGPVYGFQWRHFGA 141
Query: 396 RYTDMHADYTGQGFDQLLDVI 416
+Y DYTG+G DQL +VI
Sbjct: 142 KYKTCDDDYTGEGIDQLAEVI 162
>B6K7B9_SCHJY (tr|B6K7B9) Thymidylate synthase OS=Schizosaccharomyces japonicus
(strain yFS275 / FY16936) GN=SJAG_04627 PE=3 SV=1
Length = 619
Score = 194 bits (494), Expect = 1e-47, Method: Compositional matrix adjust.
Identities = 108/231 (46%), Positives = 142/231 (61%), Gaps = 17/231 (7%)
Query: 195 ITEIETSIDCDTFIPKID------SSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESH 248
I ++E S+ +PK D S+V P + P+ ++ +T + + E
Sbjct: 239 INDVEVSLPSARKLPKSDEVNDAASTVSAPAATYAPVSDSIEEAETSTLAKAPNATCEQD 298
Query: 249 GQ-DNGLSSDNSYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTL 307
Q +NG + + + +P +V EE YL L++ I+ G L++DRTGTGT
Sbjct: 299 VQIENGPALKEEH--------TSIPDIVPSNKEEQQYLDLIKRILETGELRNDRTGTGTR 350
Query: 308 SKFGC-QMRFNL-RRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNAS 365
S F Q+RF+L T PLLTTKKVF RGV++ELLWF+ G TN K L EK IHIWDGN S
Sbjct: 351 SIFAPPQLRFSLSNNTLPLLTTKKVFLRGVLQELLWFLRGDTNAKHLTEKDIHIWDGNGS 410
Query: 366 RDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
R++LD +G DR EGDLGPVYGFQWRHFGA+YTD +ADYTGQG DQL V+
Sbjct: 411 REFLDKMGFFDRAEGDLGPVYGFQWRHFGAKYTDCNADYTGQGVDQLAQVV 461
>Q9DGH5_DANRE (tr|Q9DGH5) Thymidylate synthase OS=Danio rerio GN=tyms PE=2 SV=1
Length = 319
Score = 194 bits (494), Expect = 1e-47, Method: Compositional matrix adjust.
Identities = 90/137 (65%), Positives = 106/137 (77%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL LV+ I+ +G K DRTGTG +S FG Q R++LR FPLLTTK+VFW+G++EEL
Sbjct: 35 DERGYLSLVEFILQNGAKKGDRTGTGVISVFGTQARYSLRDQFPLLTTKRVFWKGILEEL 94
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWFI GSTN K L EKG+ IWD N SR++LD G DREEGDLGPVYGFQWRHFGA Y D
Sbjct: 95 LWFIKGSTNAKDLSEKGVRIWDANGSREFLDKNGFTDREEGDLGPVYGFQWRHFGAEYKD 154
Query: 400 MHADYTGQGFDQLLDVI 416
MH DY+G+G DQL VI
Sbjct: 155 MHTDYSGEGVDQLQKVI 171
>Q6P045_DANRE (tr|Q6P045) Thymidylate synthase OS=Danio rerio GN=tyms PE=2 SV=1
Length = 318
Score = 194 bits (494), Expect = 1e-47, Method: Compositional matrix adjust.
Identities = 90/137 (65%), Positives = 106/137 (77%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL LV+ I+ +G K DRTGTG +S FG Q R++LR FPLLTTK+VFW+G++EEL
Sbjct: 34 DERGYLSLVEFILQNGAKKGDRTGTGVISVFGTQARYSLRDQFPLLTTKRVFWKGILEEL 93
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWFI GSTN K L EKG+ IWD N SR++LD G DREEGDLGPVYGFQWRHFGA Y D
Sbjct: 94 LWFIKGSTNAKDLSEKGVRIWDANGSREFLDKNGFTDREEGDLGPVYGFQWRHFGAEYKD 153
Query: 400 MHADYTGQGFDQLLDVI 416
MH DY+G+G DQL VI
Sbjct: 154 MHTDYSGEGVDQLQKVI 170
>Q7ZUI7_DANRE (tr|Q7ZUI7) Thymidylate synthase OS=Danio rerio GN=tyms PE=2 SV=1
Length = 319
Score = 194 bits (494), Expect = 1e-47, Method: Compositional matrix adjust.
Identities = 90/137 (65%), Positives = 106/137 (77%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL LV+ I+ +G K DRTGTG +S FG Q R++LR FPLLTTK+VFW+G++EEL
Sbjct: 35 DERGYLSLVEFILQNGAKKGDRTGTGVISVFGTQARYSLRDQFPLLTTKRVFWKGILEEL 94
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWFI GSTN K L EKG+ IWD N SR++LD G DREEGDLGPVYGFQWRHFGA Y D
Sbjct: 95 LWFIKGSTNAKDLSEKGVRIWDANGSREFLDKNGFTDREEGDLGPVYGFQWRHFGAEYKD 154
Query: 400 MHADYTGQGFDQLLDVI 416
MH DY+G+G DQL VI
Sbjct: 155 MHTDYSGEGVDQLQKVI 171
>D3JLA5_TRYCR (tr|D3JLA5) Thymidylate synthase (Fragment) OS=Trypanosoma cruzi
GN=DHFR-TS PE=3 SV=1
Length = 364
Score = 194 bits (493), Expect = 2e-47, Method: Compositional matrix adjust.
Identities = 116/256 (45%), Positives = 143/256 (55%), Gaps = 30/256 (11%)
Query: 165 YCLSIEKVFIIGGGQILRESLNAPGC---DAIHITEIETSIDCDTFIPKIDSSVFQPWYS 221
Y SIE V+ IGGG + E+L P AI+ T I S + SVF
Sbjct: 13 YTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRAS--------ESSCSVF----- 59
Query: 222 SFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKFSFLPKMVFERHEE 281
F + E+ +A Q +S + + K+ F K++ EE
Sbjct: 60 -FRVPESGTE-----------AAAGIEWQRETISEELTSANGNETKYYF-EKLIPRNREE 106
Query: 282 FLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVEELL 340
YL LV II +GN+K DRTG GTLS FG QMRF+LR PLLTTK+VFWRGV EELL
Sbjct: 107 EQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELL 166
Query: 341 WFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDM 400
WF+ G T K L +KG+HIWD N SR +LD GL + EE DLGPVYGFQWRHFGA YT
Sbjct: 167 WFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAYTHH 226
Query: 401 HADYTGQGFDQLLDVI 416
A+Y GQG DQ+ ++
Sbjct: 227 DANYDGQGVDQIKAIV 242
>Q80BK9_SHV2 (tr|Q80BK9) Thymidylate synthase OS=Saimiriine herpesvirus 2 PE=3
SV=1
Length = 294
Score = 193 bits (490), Expect = 4e-47, Method: Compositional matrix adjust.
Identities = 91/140 (65%), Positives = 104/140 (74%)
Query: 277 ERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVV 336
ERH E YL VQ I++ G+ K+DRTGTGTLS FG Q RF+L FPLLTTK+VFWRGVV
Sbjct: 7 ERHGEHQYLSQVQHILNYGSFKNDRTGTGTLSIFGTQSRFSLENEFPLLTTKRVFWRGVV 66
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWFI GST+ K L G+HIWD N SR +LD +G DR+EGDLGPVYGFQWRHFGA
Sbjct: 67 EELLWFIRGSTDSKELSAAGVHIWDANGSRSFLDKLGFYDRDEGDLGPVYGFQWRHFGAE 126
Query: 397 YTDMHADYTGQGFDQLLDVI 416
Y DY G+G DQL +I
Sbjct: 127 YRGSKRDYKGEGVDQLKQLI 146
>Q6WEA3_9EUKA (tr|Q6WEA3) Thymidylate synthase (Fragment) OS=Hartmannella
cantabrigiensis PE=4 SV=1
Length = 136
Score = 192 bits (489), Expect = 5e-47, Method: Compositional matrix adjust.
Identities = 90/130 (69%), Positives = 101/130 (77%), Gaps = 1/130 (0%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVV 336
RHEE+ YL ++ DII G KDDRTG GT+SKFG QMRF+LR FPLLTTK+VFW+GVV
Sbjct: 7 RHEEYQYLEMIDDIIRHGVSKDDRTGVGTISKFGAQMRFSLRDGVFPLLTTKRVFWKGVV 66
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWFI G TN L +KG+ IWD N SR +LD GL REE DLGPVYGFQWRHFGA+
Sbjct: 67 EELLWFIRGDTNGANLSKKGVKIWDANGSRQFLDSRGLTQREENDLGPVYGFQWRHFGAK 126
Query: 397 YTDMHADYTG 406
Y DMH DYTG
Sbjct: 127 YVDMHTDYTG 136
>C4WVP2_ACYPI (tr|C4WVP2) Thymidylate synthase OS=Acyrthosiphon pisum
GN=ACYPI006453 PE=2 SV=1
Length = 299
Score = 192 bits (487), Expect = 7e-47, Method: Compositional matrix adjust.
Identities = 90/142 (63%), Positives = 107/142 (75%), Gaps = 1/142 (0%)
Query: 276 FERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRG 334
+ +E YL ++ I+ G+ K DRT GTLS FG QMR+NL FPLLTTK+VFWRG
Sbjct: 10 YNNDDEQQYLDHIKKILEKGHKKMDRTRVGTLSLFGIQMRYNLMDGVFPLLTTKRVFWRG 69
Query: 335 VVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFG 394
VVEELLWFI GSTN K L EK + +WD N++R YLD IGL DREEGDLGPVYGFQWRH+G
Sbjct: 70 VVEELLWFIKGSTNSKELSEKDVKVWDANSTRSYLDSIGLTDREEGDLGPVYGFQWRHYG 129
Query: 395 ARYTDMHADYTGQGFDQLLDVI 416
A Y D+H DY+G+G DQL +VI
Sbjct: 130 AEYVDVHTDYSGKGIDQLQNVI 151
>B5XCJ1_SALSA (tr|B5XCJ1) Thymidylate synthase OS=Salmo salar GN=TYSY PE=2 SV=1
Length = 333
Score = 192 bits (487), Expect = 8e-47, Method: Compositional matrix adjust.
Identities = 88/137 (64%), Positives = 104/137 (75%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL + I+ G+ K DRTGTG +S FG Q R++LR FPLLTTK+VFW+G++EEL
Sbjct: 49 DERGYLNQCEYILQHGHRKGDRTGTGVISVFGSQTRYSLRDQFPLLTTKRVFWKGILEEL 108
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWFI GSTN K L EKG+ IWD N SR +LD +G DREEGDLGPVYGFQWRH+GA Y+D
Sbjct: 109 LWFIKGSTNAKELTEKGVRIWDANGSRQFLDKMGFTDREEGDLGPVYGFQWRHYGAEYSD 168
Query: 400 MHADYTGQGFDQLLDVI 416
M DYTGQG DQL VI
Sbjct: 169 MRKDYTGQGVDQLQKVI 185
>Q16JK1_AEDAE (tr|Q16JK1) Thymidylate synthase OS=Aedes aegypti GN=AAEL013305
PE=3 SV=1
Length = 313
Score = 192 bits (487), Expect = 8e-47, Method: Compositional matrix adjust.
Identities = 91/142 (64%), Positives = 107/142 (75%), Gaps = 1/142 (0%)
Query: 276 FERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR-RTFPLLTTKKVFWRG 334
F EE YL +Q II G+ + DRTG GTLS FG QMR++LR PLLTTK+VF+RG
Sbjct: 24 FRNVEEMQYLEAIQRIIDTGDKRVDRTGVGTLSIFGTQMRYSLRDNVIPLLTTKRVFFRG 83
Query: 335 VVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFG 394
V EELLWFI GSTN K LQ K +HIWDGN++R++LD G DR+EGDLGPVYGFQWRHFG
Sbjct: 84 VAEELLWFIRGSTNAKDLQAKNVHIWDGNSTREFLDASGFTDRDEGDLGPVYGFQWRHFG 143
Query: 395 ARYTDMHADYTGQGFDQLLDVI 416
A+Y + DYTGQG DQL +VI
Sbjct: 144 AKYKTCNDDYTGQGIDQLAEVI 165
>Q9YTJ6_ATHV3 (tr|Q9YTJ6) Thymidylate synthase OS=Ateline herpesvirus 3 PE=3 SV=1
Length = 290
Score = 191 bits (486), Expect = 1e-46, Method: Compositional matrix adjust.
Identities = 89/140 (63%), Positives = 103/140 (73%)
Query: 277 ERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVV 336
E H E YL V+ I++ GN K DRTG GTLS FG Q R++L + FPLLTTK+VFWRGVV
Sbjct: 3 EPHAEHQYLSQVKHILNCGNFKHDRTGVGTLSVFGMQSRYSLEKDFPLLTTKRVFWRGVV 62
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWFI GST+ K L G+HIWD N SR YLD +G DREEGDLGPVYGFQWRHFGA
Sbjct: 63 EELLWFIRGSTDSKELAASGVHIWDANGSRSYLDKLGFCDREEGDLGPVYGFQWRHFGAE 122
Query: 397 YTDMHADYTGQGFDQLLDVI 416
Y + +Y G+G DQL +I
Sbjct: 123 YQGLKHNYGGEGVDQLKQII 142
>C1BZP1_ESOLU (tr|C1BZP1) Thymidylate synthase OS=Esox lucius GN=TYSY PE=2 SV=1
Length = 319
Score = 191 bits (485), Expect = 1e-46, Method: Compositional matrix adjust.
Identities = 88/137 (64%), Positives = 106/137 (77%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL + I+ G+ K DRTGTG +S FG Q R++LR FPLLTTK+VFW+G++EEL
Sbjct: 35 DERGYLNQCEYILQHGHRKGDRTGTGVISVFGSQARYSLRDQFPLLTTKRVFWKGILEEL 94
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWFI GSTN K L EKG+ IWD N SRD+LD +G DREEGDLGPVYGFQW HFGA Y++
Sbjct: 95 LWFIKGSTNAKGLSEKGVKIWDANGSRDFLDKMGFTDREEGDLGPVYGFQWWHFGAEYSN 154
Query: 400 MHADYTGQGFDQLLDVI 416
MH DYTG+G DQL +VI
Sbjct: 155 MHTDYTGKGVDQLQNVI 171
>Q0IHX3_XENTR (tr|Q0IHX3) Thymidylate synthase OS=Xenopus tropicalis GN=tyms PE=2
SV=1
Length = 308
Score = 191 bits (484), Expect = 2e-46, Method: Compositional matrix adjust.
Identities = 87/140 (62%), Positives = 106/140 (75%)
Query: 277 ERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVV 336
E +E YL ++ I+ G+ K+DRTGTGT+S FG Q R++LR FPLLTTK+VFW+GV+
Sbjct: 21 ENRDELQYLDQIKHILERGHRKEDRTGTGTVSVFGMQARYSLRDQFPLLTTKRVFWKGVL 80
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWFI G TN K L KG+ IWD N SR++LD G +REEGDLGPVYGFQWRHFGA
Sbjct: 81 EELLWFIKGCTNSKELSAKGVKIWDANGSREFLDKQGFSNREEGDLGPVYGFQWRHFGAE 140
Query: 397 YTDMHADYTGQGFDQLLDVI 416
Y D + DY+GQG DQL +VI
Sbjct: 141 YKDTYTDYSGQGVDQLRNVI 160
>B3NAN1_DROER (tr|B3NAN1) Thymidylate synthase OS=Drosophila erecta GN=GG24473
PE=3 SV=1
Length = 304
Score = 191 bits (484), Expect = 2e-46, Method: Compositional matrix adjust.
Identities = 84/137 (61%), Positives = 107/137 (78%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL L+ +I+++G + DRT GTLS FGCQMRFN+R +FPLLTTK+VF+R V EEL
Sbjct: 19 DEMQYLDLLSEILANGEQRMDRTEVGTLSMFGCQMRFNMRESFPLLTTKRVFFRAVAEEL 78
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWF++G T+ K+LQ K +HIWDGN+SR++LD +GL +R GDLGPVYGFQWRHFGA Y
Sbjct: 79 LWFVAGKTDAKLLQAKNVHIWDGNSSREFLDSLGLTERSVGDLGPVYGFQWRHFGAEYAT 138
Query: 400 MHADYTGQGFDQLLDVI 416
DY+G+G DQL VI
Sbjct: 139 CDDDYSGKGIDQLRRVI 155
>A1L2V6_XENLA (tr|A1L2V6) Thymidylate synthase OS=Xenopus laevis GN=tyms PE=2
SV=1
Length = 309
Score = 190 bits (483), Expect = 2e-46, Method: Compositional matrix adjust.
Identities = 87/140 (62%), Positives = 104/140 (74%)
Query: 277 ERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVV 336
E +E YL ++ I+ G+ K+DRTGTGT+S FG Q R++LR FPLLTTK+VFW+GV+
Sbjct: 22 ENRDELQYLDQIKYILEHGHRKEDRTGTGTVSVFGMQARYSLRDQFPLLTTKRVFWKGVL 81
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWF+ G TN K L KG+ IWD N SR++LD G REEGDLGPVYGFQWRHFGA
Sbjct: 82 EELLWFVKGCTNSKELSAKGVKIWDANGSREFLDKQGFSTREEGDLGPVYGFQWRHFGAE 141
Query: 397 YTDMHADYTGQGFDQLLDVI 416
Y D H DY+GQG DQL VI
Sbjct: 142 YKDTHTDYSGQGVDQLQHVI 161
>Q6WEA7_9EUKA (tr|Q6WEA7) Thymidylate synthase (Fragment) OS=Hartmannella
cantabrigiensis PE=4 SV=1
Length = 136
Score = 190 bits (483), Expect = 2e-46, Method: Compositional matrix adjust.
Identities = 89/130 (68%), Positives = 100/130 (76%), Gaps = 1/130 (0%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVV 336
RHEE+ YL ++ DII G KDDRTG GT+SKFG QMRF+LR FPLLTTK+VFW+GVV
Sbjct: 7 RHEEYQYLEMIDDIIRHGVSKDDRTGVGTISKFGAQMRFSLRDGVFPLLTTKRVFWKGVV 66
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWFI G N L +KG+ IWD N SR +LD GL REE DLGPVYGFQWRHFGA+
Sbjct: 67 EELLWFIRGDINGANLSKKGVKIWDANGSRQFLDSRGLTQREENDLGPVYGFQWRHFGAK 126
Query: 397 YTDMHADYTG 406
Y DMH DYTG
Sbjct: 127 YVDMHTDYTG 136
>A8XXD3_CAEBR (tr|A8XXD3) Thymidylate synthase OS=Caenorhabditis briggsae
GN=CBG20269 PE=3 SV=1
Length = 315
Score = 190 bits (483), Expect = 3e-46, Method: Compositional matrix adjust.
Identities = 86/139 (61%), Positives = 109/139 (78%), Gaps = 1/139 (0%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVE 337
+EF YL+ V+ I+ +G+ +DDRTGTGT+S FG Q +++LR T PLLTTK+V+W+GV+E
Sbjct: 29 QDEFKYLKQVEQILQEGSRRDDRTGTGTISIFGMQSKYSLRNDTIPLLTTKRVYWKGVLE 88
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWFISGST+ K+L K + IW+ N R +LD +G REEGDLGPVYGFQWRHFGA+Y
Sbjct: 89 ELLWFISGSTDGKLLMAKNVKIWEKNGDRAFLDNLGFTSREEGDLGPVYGFQWRHFGAKY 148
Query: 398 TDMHADYTGQGFDQLLDVI 416
D H DYTGQG DQL +VI
Sbjct: 149 VDCHTDYTGQGIDQLAEVI 167
>B4KHK2_DROMO (tr|B4KHK2) Thymidylate synthase OS=Drosophila mojavensis
GN=GI10845 PE=3 SV=1
Length = 310
Score = 190 bits (483), Expect = 3e-46, Method: Compositional matrix adjust.
Identities = 89/137 (64%), Positives = 107/137 (78%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL L++ II +G+ + DRT GT S FG QMRFNLR +FPLLTTK+VF+RGV EEL
Sbjct: 24 DEEQYLDLIKRIIENGDERMDRTKVGTRSIFGAQMRFNLRDSFPLLTTKRVFFRGVAEEL 83
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
+WFI+G T+ K+LQEK IHIWDGN++R++LD G DRE GDLGPVYGFQWRHFGA+Y
Sbjct: 84 IWFIAGQTDAKILQEKNIHIWDGNSTREFLDKCGHTDREVGDLGPVYGFQWRHFGAKYGK 143
Query: 400 MHADYTGQGFDQLLDVI 416
DYTGQG DQL VI
Sbjct: 144 CTDDYTGQGIDQLKQVI 160
>Q2F5K5_BOMMO (tr|Q2F5K5) Thymidylate synthase OS=Bombyx mori PE=2 SV=1
Length = 298
Score = 190 bits (482), Expect = 3e-46, Method: Compositional matrix adjust.
Identities = 88/142 (61%), Positives = 105/142 (73%), Gaps = 1/142 (0%)
Query: 276 FERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRG 334
+ H+E+ YL+L+ II G+ + DRTG GTLS FG R++L T PLLTTK+VF RG
Sbjct: 9 IKSHDEYQYLKLIDQIIKSGDKRVDRTGVGTLSIFGAMQRYSLHNNTLPLLTTKRVFTRG 68
Query: 335 VVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFG 394
V+EELLW ISGST+ K L KG+HIWD N SR++LD +G DREEGDLGPVYGFQWRH G
Sbjct: 69 VIEELLWMISGSTDSKALAAKGVHIWDANGSRNFLDNLGFTDREEGDLGPVYGFQWRHSG 128
Query: 395 ARYTDMHADYTGQGFDQLLDVI 416
A+Y D DYTGQG DQL VI
Sbjct: 129 AKYIDCQTDYTGQGIDQLQSVI 150
>Q6WEA1_9EUKA (tr|Q6WEA1) Thymidylate synthase (Fragment) OS=Hartmannella
cantabrigiensis PE=4 SV=1
Length = 136
Score = 189 bits (481), Expect = 4e-46, Method: Compositional matrix adjust.
Identities = 90/130 (69%), Positives = 100/130 (76%), Gaps = 1/130 (0%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVV 336
RHEE+ YL ++ DII G KDDRTG GT+SKFG QMRF+LR FPLLTTK+VFW+GVV
Sbjct: 7 RHEEYQYLEMIDDIIRHGVRKDDRTGVGTISKFGAQMRFSLRDGVFPLLTTKRVFWKGVV 66
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWFI G TN L +KG IWD N SR +LD GL REE DLGPVYGFQWRHFGA+
Sbjct: 67 EELLWFIRGDTNGANLSKKGDKIWDANGSRQFLDSRGLTHREENDLGPVYGFQWRHFGAK 126
Query: 397 YTDMHADYTG 406
Y DMH DYTG
Sbjct: 127 YVDMHTDYTG 136
>Q9NDD3_TRISP (tr|Q9NDD3) Thymidylate synthase OS=Trichinella spiralis GN=ts PE=2
SV=2
Length = 307
Score = 189 bits (481), Expect = 4e-46, Method: Compositional matrix adjust.
Identities = 92/142 (64%), Positives = 107/142 (75%), Gaps = 1/142 (0%)
Query: 276 FERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRG 334
+ EE YL ++DII G K+DRTG GTLS FG Q R+ LR FPLLTTK+VFWRG
Sbjct: 18 YVNQEELNYLNQLKDIIDHGVRKNDRTGIGTLSTFGTQSRYCLRDDIFPLLTTKRVFWRG 77
Query: 335 VVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFG 394
VVEELLWFISGSTN K L EK ++IWDGN+SR++LD GL + EEGDLGPVYGFQWRHFG
Sbjct: 78 VVEELLWFISGSTNAKQLSEKNVNIWDGNSSREFLDSRGLYNYEEGDLGPVYGFQWRHFG 137
Query: 395 ARYTDMHADYTGQGFDQLLDVI 416
Y+ M ADY G+G+DQL I
Sbjct: 138 CPYSSMTADYKGKGYDQLQQCI 159
>Q5DGT4_SCHJA (tr|Q5DGT4) Thymidylate synthase OS=Schistosoma japonicum PE=2 SV=1
Length = 317
Score = 189 bits (479), Expect = 7e-46, Method: Compositional matrix adjust.
Identities = 91/157 (57%), Positives = 115/157 (73%), Gaps = 4/157 (2%)
Query: 261 IKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR 320
++ + +FSF + +F E YL L+Q I++ G ++DRT TGTL+ FG Q+RF+LR
Sbjct: 16 VQSQPAEFSFFAEHIFG---ENGYLNLLQYILAKGTERNDRTNTGTLAVFGPQLRFSLRN 72
Query: 321 T-FPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREE 379
+PLLTTK VF+RG+VEELLWFI GSTN + L EK +H WD N SR++LDG+G +REE
Sbjct: 73 NEYPLLTTKTVFFRGIVEELLWFIRGSTNSRELSEKNVHFWDANGSREFLDGLGFTEREE 132
Query: 380 GDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GDLGP+YGFQWRH GA Y D DYTGQG DQL DVI
Sbjct: 133 GDLGPIYGFQWRHSGAEYIDCRTDYTGQGVDQLADVI 169
>C4Q3X9_SCHMA (tr|C4Q3X9) Thymidylate synthase OS=Schistosoma mansoni
GN=Smp_135460 PE=3 SV=1
Length = 577
Score = 188 bits (478), Expect = 8e-46, Method: Compositional matrix adjust.
Identities = 91/150 (60%), Positives = 110/150 (73%), Gaps = 4/150 (2%)
Query: 268 FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR-RTFPLLT 326
FSF P+ +F E YL L++ I+++G + DRT TGT FG Q+RF+LR +PLLT
Sbjct: 283 FSFFPEHIFG---ENGYLNLLRYILANGVERRDRTDTGTFGVFGPQLRFSLRNHEYPLLT 339
Query: 327 TKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVY 386
TK VF+RG+VEELLWFI GSTN + L EK +H WD N SR++LDG+G +REEGDLGPVY
Sbjct: 340 TKTVFFRGIVEELLWFIRGSTNSRELAEKNVHFWDANGSREFLDGLGFTEREEGDLGPVY 399
Query: 387 GFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GFQWRH GA Y D DYTGQG DQL DVI
Sbjct: 400 GFQWRHSGAEYVDCQTDYTGQGVDQLADVI 429
>Q9Y052_CAEEL (tr|Q9Y052) Thymidylate synthase OS=Caenorhabditis elegans PE=2
SV=1
Length = 315
Score = 188 bits (477), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 86/145 (59%), Positives = 110/145 (75%), Gaps = 1/145 (0%)
Query: 273 KMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVF 331
+ V +E+ YL+ V+ I+ +G +DDRTGTGT+S FG Q ++ LR T PLLTTK+V+
Sbjct: 23 QQVHLNQDEYKYLKQVEQILREGTRRDDRTGTGTISIFGMQSKYCLRNGTIPLLTTKRVY 82
Query: 332 WRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWR 391
W+GV+EELLWFISGST+ K+L EK + IW+ N R +LD +G REEGDLGPVYGFQWR
Sbjct: 83 WKGVLEELLWFISGSTDGKLLMEKNVKIWEKNGDRAFLDNLGFTSREEGDLGPVYGFQWR 142
Query: 392 HFGARYTDMHADYTGQGFDQLLDVI 416
HFGA+Y D H DY+GQG DQL +VI
Sbjct: 143 HFGAKYVDCHTDYSGQGVDQLAEVI 167
>Q9N588_CAEEL (tr|Q9N588) Thymidylate synthase OS=Caenorhabditis elegans
GN=Y110A7A.4 PE=2 SV=1
Length = 312
Score = 188 bits (477), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 86/145 (59%), Positives = 110/145 (75%), Gaps = 1/145 (0%)
Query: 273 KMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVF 331
+ V +E+ YL+ V+ I+ +G +DDRTGTGT+S FG Q ++ LR T PLLTTK+V+
Sbjct: 20 QQVHLNQDEYKYLKQVEQILREGTRRDDRTGTGTISIFGMQSKYCLRNGTIPLLTTKRVY 79
Query: 332 WRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWR 391
W+GV+EELLWFISGST+ K+L EK + IW+ N R +LD +G REEGDLGPVYGFQWR
Sbjct: 80 WKGVLEELLWFISGSTDGKLLMEKNVKIWEKNGDRAFLDNLGFTSREEGDLGPVYGFQWR 139
Query: 392 HFGARYTDMHADYTGQGFDQLLDVI 416
HFGA+Y D H DY+GQG DQL +VI
Sbjct: 140 HFGAKYVDCHTDYSGQGVDQLAEVI 164
>D2HJY4_AILME (tr|D2HJY4) Thymidylate synthase (Fragment) OS=Ailuropoda
melanoleuca GN=PANDA_011650 PE=3 SV=1
Length = 276
Score = 188 bits (477), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 88/128 (68%), Positives = 100/128 (78%)
Query: 289 QDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTN 348
+ I+ G KDDRTGTGTLS FG Q R++LR FPLLTTK+VFW+GV+EELLWFI GSTN
Sbjct: 1 EHILRCGVRKDDRTGTGTLSVFGLQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTN 60
Query: 349 CKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQG 408
K L KG+ IWD N SRD+LD +G REEGDLGPVYGFQWRHFGA Y DM +DY+GQG
Sbjct: 61 AKELSSKGVKIWDANGSRDFLDSLGFCSREEGDLGPVYGFQWRHFGAEYKDMDSDYSGQG 120
Query: 409 FDQLLDVI 416
DQL VI
Sbjct: 121 IDQLQKVI 128
>Q9E202_9ALPH (tr|Q9E202) Thymidylate synthase OS=Cercopithecine herpesvirus 9
PE=3 SV=1
Length = 295
Score = 188 bits (477), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 87/139 (62%), Positives = 103/139 (74%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVE 337
+H E+ YL V I+ +G K DRTGTGTLS FG Q R+NLR FPLLTTK+VFW+GVVE
Sbjct: 9 KHSEYQYLEQVNFILHNGVQKTDRTGTGTLSVFGMQSRYNLRNEFPLLTTKRVFWKGVVE 68
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWFI GSTN L EKG+ IW + S+ +L G +R+EGDLGPVYGFQWRHFGA Y
Sbjct: 69 ELLWFIKGSTNSTELVEKGVKIWSAHGSKQFLHSNGFDNRQEGDLGPVYGFQWRHFGAEY 128
Query: 398 TDMHADYTGQGFDQLLDVI 416
DM+ +Y GQG DQL +VI
Sbjct: 129 VDMNTNYFGQGVDQLQNVI 147
>B4NLJ1_DROWI (tr|B4NLJ1) Thymidylate synthase OS=Drosophila willistoni
GN=GK18389 PE=3 SV=1
Length = 340
Score = 188 bits (477), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 85/137 (62%), Positives = 103/137 (75%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL L++ II G + DRT GTLS FG QMRF++R +FPLLTTK+VF+R V EEL
Sbjct: 54 DEEQYLDLLRSIIERGETRIDRTRVGTLSIFGSQMRFDMRESFPLLTTKRVFFRAVAEEL 113
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWFI G T+ K+LQ+K +HIWDGN++R++LD +G DR GDLGPVYGFQWRHFGA Y
Sbjct: 114 LWFIKGKTDAKILQDKNVHIWDGNSTREFLDNLGFTDRAVGDLGPVYGFQWRHFGAEYRT 173
Query: 400 MHADYTGQGFDQLLDVI 416
DYTGQG DQL VI
Sbjct: 174 CQDDYTGQGVDQLRQVI 190
>D2XB64_9VIRU (tr|D2XB64) Bifunctional dihydrofolate reductase-thymidylate
synthase OS=Marseillevirus GN=MAR_ORF429 PE=4 SV=1
Length = 444
Score = 187 bits (476), Expect = 1e-45, Method: Compositional matrix adjust.
Identities = 119/357 (33%), Positives = 177/357 (49%), Gaps = 67/357 (18%)
Query: 63 YQVVVAATRDMGIGKEGKLPWRLPSDLKFFKDVTLTTSDSGRKNAVIMGRKTWESIPLEH 122
Y +V A + GIG +G++PW LP DL F+ +T GR +I GRKT ES P
Sbjct: 4 YYLVFACDQRGGIGNKGRIPWHLPEDLAIFQRMTF-----GR--TIIYGRKTLESFP-GS 55
Query: 123 RPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILR 182
+PL R N++++R+ ++ AE + L ++GG +I +
Sbjct: 56 KPLAKRRNIIVSRNSDLNVDGAE-----------VAHSLEEAFSLVQGHCIVVGGSEIYK 104
Query: 183 ESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRV 242
+ L FP +C R
Sbjct: 105 QCLE-----------------------------------QFP------DFCLGV---SRT 120
Query: 243 SAVESHGQDNGLSSDNSYIKFEVKK-FSFLPKMVFERHE-EFLYLRLVQDIISDGNLKDD 300
+E++ D S + + +K +F M+F ++E E YL L+ +++ G + D
Sbjct: 121 LVLETYEADTWFSVKEAKYNYLIKSSHNFETAMMFRKNEGELAYLSLLSEVLYSGEKRKD 180
Query: 301 RTGTGTLSKFGCQMRF-NLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHI 359
RTGTGT S FG + F N+ FPL+T K++ W ++ ELLWF+SGST+ K+L+ + +I
Sbjct: 181 RTGTGTRSLFGRHLLFENISEKFPLITVKRMAWGCILSELLWFLSGSTDSKMLELQNNNI 240
Query: 360 WDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
W N+SR +LDG GL R EGD GP+YGFQWRH+GA+Y D DY GQG DQ+L +I
Sbjct: 241 WKKNSSRKFLDGRGLSYR-EGDCGPIYGFQWRHWGAKYVDCDTDYRGQGEDQILSII 296
>Q2HRC4_HHV8P (tr|Q2HRC4) Thymidylate synthase OS=Human herpesvirus 8 type P
(isolate GK18) GN=ORF70 PE=3 SV=1
Length = 337
Score = 187 bits (476), Expect = 2e-45, Method: Compositional matrix adjust.
Identities = 87/134 (64%), Positives = 103/134 (76%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEE 338
HEE YLR +++I+ G+ + DRTG GTLS FG Q R++LR FPLLTTK+VFWRGVV+E
Sbjct: 52 HEELQYLRQLREILCRGSDRLDRTGIGTLSLFGMQARYSLRDHFPLLTTKRVFWRGVVQE 111
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF+ GST+ + L G+ IWD N SR++L G GL R EGDLGPVYGFQWRHFGA Y
Sbjct: 112 LLWFLKGSTDSRELSRTGVKIWDKNGSREFLAGRGLAHRREGDLGPVYGFQWRHFGAAYV 171
Query: 399 DMHADYTGQGFDQL 412
D ADYTGQGFDQL
Sbjct: 172 DADADYTGQGFDQL 185
>D0UZM0_HHV8 (tr|D0UZM0) Thymidylate synthase OS=Human herpesvirus 8 PE=3 SV=1
Length = 337
Score = 187 bits (476), Expect = 2e-45, Method: Compositional matrix adjust.
Identities = 87/134 (64%), Positives = 103/134 (76%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEE 338
HEE YLR +++I+ G+ + DRTG GTLS FG Q R++LR FPLLTTK+VFWRGVV+E
Sbjct: 52 HEELQYLRQLREILCRGSDRLDRTGIGTLSLFGMQARYSLRDHFPLLTTKRVFWRGVVQE 111
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF+ GST+ + L G+ IWD N SR++L G GL R EGDLGPVYGFQWRHFGA Y
Sbjct: 112 LLWFLKGSTDSRELSRTGVKIWDKNGSREFLAGRGLAHRREGDLGPVYGFQWRHFGAAYV 171
Query: 399 DMHADYTGQGFDQL 412
D ADYTGQGFDQL
Sbjct: 172 DADADYTGQGFDQL 185
>Q6WEA5_9EUKA (tr|Q6WEA5) Thymidylate synthase (Fragment) OS=Hartmannella
cantabrigiensis PE=4 SV=1
Length = 136
Score = 187 bits (476), Expect = 2e-45, Method: Compositional matrix adjust.
Identities = 89/130 (68%), Positives = 100/130 (76%), Gaps = 1/130 (0%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVV 336
RHEE+ YL ++ DII G KDDRTG GT+SKFG QMRF+LR FPLLTTK+VFW+GVV
Sbjct: 7 RHEEYQYLEMIDDIIRHGVSKDDRTGVGTISKFGAQMRFSLRDGVFPLLTTKRVFWKGVV 66
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWFI G TN L +KG+ I D N SR +LD GL REE DLGPVYGFQWRHFGA+
Sbjct: 67 EELLWFIRGDTNGANLSKKGVKICDANGSRQFLDSRGLTQREENDLGPVYGFQWRHFGAK 126
Query: 397 YTDMHADYTG 406
Y DMH DYTG
Sbjct: 127 YVDMHTDYTG 136
>Q91LI6_WSSV (tr|Q91LI6) Thymidylate synthase OS=White spot syndrome virus PE=3
SV=1
Length = 289
Score = 187 bits (475), Expect = 2e-45, Method: Compositional matrix adjust.
Identities = 90/137 (65%), Positives = 107/137 (78%), Gaps = 1/137 (0%)
Query: 281 EFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEEL 339
E YL LV++I+ G KDDRTGTGTLS FG QMRF+LR T P+LTTKK+FWRGVVEEL
Sbjct: 4 EHQYLNLVREILERGVKKDDRTGTGTLSIFGPQMRFSLRDDTIPVLTTKKIFWRGVVEEL 63
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWFI G+T+ K L +K IHIW+ N SR++LD GL DR EGDLGPVYGFQWRHFGA Y
Sbjct: 64 LWFIRGNTDAKELAKKKIHIWNANGSREFLDSRGLYDRAEGDLGPVYGFQWRHFGAEYDT 123
Query: 400 MHADYTGQGFDQLLDVI 416
+DYTG+G DQL +++
Sbjct: 124 CSSDYTGKGIDQLANIL 140
>A4RMX7_MAGGR (tr|A4RMX7) Thymidylate synthase OS=Magnaporthe grisea GN=MGG_04458
PE=3 SV=1
Length = 339
Score = 187 bits (475), Expect = 2e-45, Method: Compositional matrix adjust.
Identities = 88/145 (60%), Positives = 112/145 (77%), Gaps = 5/145 (3%)
Query: 277 ERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQ-MRFNLRR----TFPLLTTKKVF 331
ERHEE+ YL LV++I+ +G + DRTGTGT S F + ++F+L + PLLTTK+VF
Sbjct: 14 ERHEEYQYLDLVREILDNGEHRPDRTGTGTYSIFAPRPLKFSLNKDGTPILPLLTTKRVF 73
Query: 332 WRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWR 391
R V+ ELLWF+SG+T+ K L + G+ IWDGN SR++LDG+GL+ RE GDLGPVYGFQWR
Sbjct: 74 SRAVILELLWFVSGATSAKPLSDAGVKIWDGNGSREFLDGLGLQHREVGDLGPVYGFQWR 133
Query: 392 HFGARYTDMHADYTGQGFDQLLDVI 416
HFGA YTD HADYTGQG DQL +V+
Sbjct: 134 HFGAEYTDCHADYTGQGVDQLAEVV 158
>B4M9C1_DROVI (tr|B4M9C1) Thymidylate synthase OS=Drosophila virilis GN=GJ18288
PE=3 SV=1
Length = 348
Score = 187 bits (474), Expect = 2e-45, Method: Compositional matrix adjust.
Identities = 86/140 (61%), Positives = 105/140 (75%)
Query: 277 ERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVV 336
E +E YL ++ II +G+ + DRT GTLS FG QMRF+LR++FPLLTTK+VF+RGV
Sbjct: 59 ENMDEKQYLLFIERIIKNGDKRVDRTRVGTLSIFGAQMRFDLRKSFPLLTTKRVFFRGVA 118
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWFI+G T+ K+LQ K +HIWD N++R++LD G DR GDLGPVYGFQWRHFGA
Sbjct: 119 EELLWFIAGKTDAKILQAKKVHIWDANSTREFLDNCGHTDRAVGDLGPVYGFQWRHFGAE 178
Query: 397 YTDMHADYTGQGFDQLLDVI 416
Y DYTGQG DQL VI
Sbjct: 179 YRTCDDDYTGQGVDQLQQVI 198
>B4GSA5_DROPE (tr|B4GSA5) Thymidylate synthase OS=Drosophila persimilis
GN=GL26706 PE=3 SV=1
Length = 330
Score = 187 bits (474), Expect = 3e-45, Method: Compositional matrix adjust.
Identities = 93/177 (52%), Positives = 123/177 (69%), Gaps = 2/177 (1%)
Query: 242 VSAVESHGQDNGLSSDNSYIKFEVKKFSF-LPKMVFERH-EEFLYLRLVQDIISDGNLKD 299
+A+ + DN S IK E K+ + +P ++ E + +E YL L+Q II +G +
Sbjct: 4 AAAIPNLSSDNASPVKKSPIKREFKECNVEVPLLMQETNKDEQQYLDLIQYIIGNGERRI 63
Query: 300 DRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHI 359
DRT GTLS FG Q+RF++R +FPLLTTK+VF+R VVEEL+WF+ G T+ K+LQ K +HI
Sbjct: 64 DRTNVGTLSVFGSQLRFDMRLSFPLLTTKRVFFRAVVEELIWFVGGKTDAKLLQAKNVHI 123
Query: 360 WDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
WDGN++R+YLD +G DR GDLGPVYGFQWRHFGA Y DY+G+G DQL VI
Sbjct: 124 WDGNSTREYLDKLGHTDRAVGDLGPVYGFQWRHFGAEYGTCDDDYSGKGIDQLRQVI 180
>A8C2U4_PLAMA (tr|A8C2U4) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium malariae PE=4 SV=1
Length = 621
Score = 186 bits (473), Expect = 4e-45, Method: Compositional matrix adjust.
Identities = 82/149 (55%), Positives = 106/149 (71%)
Query: 268 FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTT 327
F + F+ H E+ YL ++ DII +GN ++DRTG G LSKFG M+FNL + FPLLTT
Sbjct: 325 FKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTGVGVLSKFGYIMKFNLNQYFPLLTT 384
Query: 328 KKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYG 387
KK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLGP+YG
Sbjct: 385 KKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYG 444
Query: 388 FQWRHFGARYTDMHADYTGQGFDQLLDVI 416
FQWRHFGA YT+MHA+Y +G DQL ++I
Sbjct: 445 FQWRHFGAEYTNMHANYENKGVDQLKNII 473
Score = 83.2 bits (204), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 55/180 (30%), Positives = 78/180 (43%), Gaps = 41/180 (22%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTT--------------------------------- 99
G+G +G LPW+ S D+K+F VT
Sbjct: 38 GLGNKGCLPWKSNSLDMKYFSSVTTYVNEMKYKKLKYKREKYLEKEISNENSSTVFENIS 97
Query: 100 --SDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXX 157
S S +N V+MGR +W SIP +++PLP R+NVVL+R+ + E++ I
Sbjct: 98 LLSSSKLQNVVVMGRSSWVSIPKQYKPLPNRINVVLSRTLKKE-DVKEDIFIINNMDQLV 156
Query: 158 XXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQ 217
Y K FIIGG + +E L I+ T I +CD F P+ID +VFQ
Sbjct: 157 LLLKKLNY----YKCFIIGGAIVYKECLERNLIKQIYFTRINNVYECDVFFPEIDENVFQ 212
>A3GG41_PICST (tr|A3GG41) Thymidylate synthase OS=Pichia stipitis GN=TMP1 PE=3
SV=1
Length = 316
Score = 186 bits (473), Expect = 4e-45, Method: Compositional matrix adjust.
Identities = 90/144 (62%), Positives = 108/144 (75%), Gaps = 2/144 (1%)
Query: 275 VFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFW 332
V E YL L + II++G + DRTGTGT S F Q+RF+L TFPLLTTKKVF
Sbjct: 3 VLPNTAEQAYLDLCEKIINEGEFRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKKVFS 62
Query: 333 RGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRH 392
RG++ ELLWF++GST+ K+L EKG+ IW+GN SR++LD +GL R EGDLGPVYGFQWRH
Sbjct: 63 RGIIHELLWFVAGSTDAKLLSEKGVKIWEGNGSREFLDNLGLTHRREGDLGPVYGFQWRH 122
Query: 393 FGARYTDMHADYTGQGFDQLLDVI 416
FGA Y D ADYTGQG+DQL DVI
Sbjct: 123 FGAEYKDCDADYTGQGYDQLADVI 146
>B4JCJ9_DROGR (tr|B4JCJ9) Thymidylate synthase OS=Drosophila grimshawi GN=GH10649
PE=3 SV=1
Length = 329
Score = 186 bits (472), Expect = 5e-45, Method: Compositional matrix adjust.
Identities = 87/137 (63%), Positives = 105/137 (76%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL L++ II G+ + DRT GTLS FG QMRF+LR +FPLLTTK+VF+RGV EEL
Sbjct: 43 DEQQYLDLLKRIIKTGDQRIDRTAVGTLSIFGTQMRFDLRDSFPLLTTKRVFFRGVAEEL 102
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWF++G TN K+LQ K +HIWD N++R++LD G DR+EGDLGPVYGFQWRHFGA Y
Sbjct: 103 LWFVAGKTNAKLLQAKKVHIWDFNSTREFLDKCGHTDRDEGDLGPVYGFQWRHFGAEYRG 162
Query: 400 MHADYTGQGFDQLLDVI 416
DYTGQG DQL VI
Sbjct: 163 CDDDYTGQGVDQLQQVI 179
>A8C2U6_PLAMA (tr|A8C2U6) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium malariae PE=4 SV=1
Length = 621
Score = 186 bits (472), Expect = 5e-45, Method: Compositional matrix adjust.
Identities = 82/149 (55%), Positives = 106/149 (71%)
Query: 268 FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTT 327
F + F+ H E+ YL ++ DII +GN ++DRTG G LSKFG M+FNL + FPLLTT
Sbjct: 325 FKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTGVGVLSKFGYIMKFNLNQYFPLLTT 384
Query: 328 KKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYG 387
KK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLGP+YG
Sbjct: 385 KKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYG 444
Query: 388 FQWRHFGARYTDMHADYTGQGFDQLLDVI 416
FQWRHFGA YT+MHA+Y +G DQL ++I
Sbjct: 445 FQWRHFGAEYTNMHANYEDKGVDQLKNII 473
Score = 83.2 bits (204), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 55/180 (30%), Positives = 78/180 (43%), Gaps = 41/180 (22%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTT--------------------------------- 99
G+G +G LPW+ S D+K+F VT
Sbjct: 38 GLGNKGCLPWKSNSLDMKYFSSVTTYVNEMKYKKLKYKREKYLEKEISNENSSTVFENIS 97
Query: 100 --SDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXX 157
S S +N V+MGR +W SIP +++PLP R+NVVL+R+ + E++ I
Sbjct: 98 LLSSSKLQNVVVMGRSSWVSIPKQYKPLPNRINVVLSRTLKKE-DVKEDIFIINNMDQLV 156
Query: 158 XXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQ 217
Y K FIIGG + +E L I+ T I +CD F P+ID +VFQ
Sbjct: 157 LLLKKLNY----YKCFIIGGAIVYKECLERNLIKQIYFTRINNVYECDVFFPEIDENVFQ 212
>A8C2U2_PLAMA (tr|A8C2U2) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium malariae PE=4 SV=1
Length = 621
Score = 186 bits (472), Expect = 5e-45, Method: Compositional matrix adjust.
Identities = 82/149 (55%), Positives = 106/149 (71%)
Query: 268 FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTT 327
F + F+ H E+ YL ++ DII +GN ++DRTG G LSKFG M+FNL + FPLLTT
Sbjct: 325 FKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTGVGVLSKFGYIMKFNLNQYFPLLTT 384
Query: 328 KKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYG 387
KK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLGP+YG
Sbjct: 385 KKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYG 444
Query: 388 FQWRHFGARYTDMHADYTGQGFDQLLDVI 416
FQWRHFGA YT+MHA+Y +G DQL ++I
Sbjct: 445 FQWRHFGAEYTNMHANYEDKGVDQLKNII 473
Score = 83.2 bits (204), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 55/180 (30%), Positives = 78/180 (43%), Gaps = 41/180 (22%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTT--------------------------------- 99
G+G +G LPW+ S D+K+F VT
Sbjct: 38 GLGNKGCLPWKSNSLDMKYFSSVTTYVNEMKYKKLKYKREKYLEKEISNENSSTVFENIS 97
Query: 100 --SDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXX 157
S S +N V+MGR +W SIP +++PLP R+NVVL+R+ + E++ I
Sbjct: 98 LLSSSKLQNVVVMGRSSWVSIPKQYKPLPNRINVVLSRTLKKE-DVKEDIFIINNMDQLV 156
Query: 158 XXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQ 217
Y K FIIGG + +E L I+ T I +CD F P+ID +VFQ
Sbjct: 157 LLLKKLNY----YKCFIIGGAIVYKECLERNLIKQIYFTRINNVYECDVFFPEIDENVFQ 212
>A8C2U7_PLABR (tr|A8C2U7) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium brasilianum PE=4 SV=1
Length = 621
Score = 186 bits (471), Expect = 5e-45, Method: Compositional matrix adjust.
Identities = 82/149 (55%), Positives = 106/149 (71%)
Query: 268 FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTT 327
F + F+ H E+ YL ++ DII +GN ++DRTG G LSKFG M+FNL + FPLLTT
Sbjct: 325 FKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTGVGVLSKFGYIMKFNLNQYFPLLTT 384
Query: 328 KKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYG 387
KK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLGP+YG
Sbjct: 385 KKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYG 444
Query: 388 FQWRHFGARYTDMHADYTGQGFDQLLDVI 416
FQWRHFGA YT+MHA+Y +G DQL ++I
Sbjct: 445 FQWRHFGAEYTNMHANYEDKGVDQLKNII 473
Score = 82.4 bits (202), Expect = 9e-14, Method: Compositional matrix adjust.
Identities = 54/180 (30%), Positives = 78/180 (43%), Gaps = 41/180 (22%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTT--------------------------------- 99
G+G +G LPW+ S D+K+F VT
Sbjct: 38 GLGNKGCLPWKSNSLDMKYFSSVTTYVNEMKYKKLKYKREKYLEKEISNENSSTVFENIS 97
Query: 100 --SDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXX 157
S S +N V+MGR +W SIP +++PLP R+NVVL+R+ + E++ I
Sbjct: 98 LLSSSKLQNVVVMGRSSWVSIPKQYKPLPNRINVVLSRTLKKE-DVKEDIFIINNMDQLV 156
Query: 158 XXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQ 217
Y K FIIGG + +E L I+ T I +CD F P++D +VFQ
Sbjct: 157 LLLKKLNY----YKCFIIGGAIVYKECLERNLIKQIYFTRINNVYECDVFFPEVDENVFQ 212
>Q91CH7_9ALPH (tr|Q91CH7) Thymidylate synthase OS=Macropodid herpesvirus 1 PE=3
SV=1
Length = 316
Score = 186 bits (471), Expect = 6e-45, Method: Compositional matrix adjust.
Identities = 88/138 (63%), Positives = 102/138 (73%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEE 338
H E+ YL V I+ +G K DRTGTGTLS FG Q R+NLR FPLLTTK+V+W+GVVEE
Sbjct: 31 HGEWQYLYQVARILREGYRKGDRTGTGTLSVFGTQARYNLRGEFPLLTTKRVYWKGVVEE 90
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF+ G+TN K L +G+ IWD + SRD+LD G REEGDLGPVYGFQWRHFGA Y
Sbjct: 91 LLWFVRGATNTKELSSRGVKIWDAHGSRDFLDKRGFPSREEGDLGPVYGFQWRHFGAEYR 150
Query: 399 DMHADYTGQGFDQLLDVI 416
ADY+GQG DQL VI
Sbjct: 151 GSEADYSGQGADQLQYVI 168
>Q0IJY2_PLAMA (tr|Q0IJY2) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium malariae PE=4 SV=1
Length = 621
Score = 186 bits (471), Expect = 6e-45, Method: Compositional matrix adjust.
Identities = 82/149 (55%), Positives = 106/149 (71%)
Query: 268 FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTT 327
F + F+ H E+ YL ++ DII +GN ++DRTG G LSKFG M+FNL + FPLLTT
Sbjct: 325 FKIYNSLKFKHHPEYQYLSIIYDIIMNGNKQNDRTGVGVLSKFGYIMKFNLNQYFPLLTT 384
Query: 328 KKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYG 387
KK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLGP+YG
Sbjct: 385 KKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYG 444
Query: 388 FQWRHFGARYTDMHADYTGQGFDQLLDVI 416
FQWRHFGA YT+MHA+Y +G DQL ++I
Sbjct: 445 FQWRHFGAEYTNMHANYEDKGVDQLKNII 473
Score = 82.8 bits (203), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 55/180 (30%), Positives = 78/180 (43%), Gaps = 41/180 (22%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTT--------------------------------- 99
G+G +G LPW+ S D+K+F VT
Sbjct: 38 GLGNKGCLPWKSNSLDMKYFSSVTTYVNEMKYKKLKYKREKYLEKEISNENSSTVFENIS 97
Query: 100 --SDSGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXX 157
S S +N V+MGR +W SIP +++PLP R+NVVL+R+ + E++ I
Sbjct: 98 LLSSSKLQNVVVMGRSSWVSIPKQYKPLPNRINVVLSRTLKKE-DVKEDIFIINNMDQLV 156
Query: 158 XXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQ 217
Y K FIIGG + +E L I+ T I +CD F P+ID +VFQ
Sbjct: 157 LLLKKLNY----YKCFIIGGAIVYKECLERNLIKQIYFTRINNVYECDVFFPEIDENVFQ 212
>D7EIA1_TRICA (tr|D7EIA1) Putative uncharacterized protein OS=Tribolium castaneum
GN=TcasGA2_TC004238 PE=4 SV=1
Length = 313
Score = 185 bits (470), Expect = 7e-45, Method: Compositional matrix adjust.
Identities = 86/139 (61%), Positives = 104/139 (74%), Gaps = 1/139 (0%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR-RTFPLLTTKKVFWRGVVE 337
HEE+ YL ++ I+ G + DRT GTLS FG QMR++LR FPLLTTK+VFWR VVE
Sbjct: 27 HEEYQYLSHIRQILEKGVQRMDRTRIGTLSIFGVQMRYSLRDNVFPLLTTKRVFWRAVVE 86
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWFI GSTN L+EK +HIWD N+SR +LD +GL++ EEGDLGP+YGFQWRHFGA Y
Sbjct: 87 ELLWFIKGSTNSNDLKEKNVHIWDANSSRAFLDSVGLEEYEEGDLGPIYGFQWRHFGAEY 146
Query: 398 TDMHADYTGQGFDQLLDVI 416
+ DYT +G DQL VI
Sbjct: 147 KGVQGDYTNEGVDQLARVI 165
>D5GJQ2_9PEZI (tr|D5GJQ2) Thymidylate synthase OS=Tuber melanosporum
GN=GSTUM_00009125001 PE=3 SV=1
Length = 306
Score = 185 bits (470), Expect = 9e-45, Method: Compositional matrix adjust.
Identities = 87/140 (62%), Positives = 108/140 (77%), Gaps = 2/140 (1%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLR-RTFPLLTTKKVFWRGVV 336
H E+ YL LV++I+++G + DRTGTGT+S F Q+RFNL+ TFPLLTTK++F + ++
Sbjct: 13 HPEYQYLDLVRNILTNGEHRPDRTGTGTISLFAPPQLRFNLKNHTFPLLTTKRLFHKAIL 72
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
ELLWFISGST+ L G+ IW+GN SR YLD IGL +R EGDLGPVYGFQWRHFGA+
Sbjct: 73 HELLWFISGSTSNAPLSAVGVKIWEGNGSRAYLDSIGLTERAEGDLGPVYGFQWRHFGAK 132
Query: 397 YTDMHADYTGQGFDQLLDVI 416
Y D H DY+GQG DQL DVI
Sbjct: 133 YVDCHTDYSGQGVDQLADVI 152
>Q8QTF3_WSSV (tr|Q8QTF3) Thymidylate synthase OS=White spot syndrome virus PE=3
SV=1
Length = 289
Score = 185 bits (469), Expect = 1e-44, Method: Compositional matrix adjust.
Identities = 89/137 (64%), Positives = 106/137 (77%), Gaps = 1/137 (0%)
Query: 281 EFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEEL 339
E YL LV++I+ G KDDRTGTGTLS FG QMRF+LR T P+LTTKK+FWRGVVEEL
Sbjct: 4 EHQYLNLVREILERGVKKDDRTGTGTLSIFGPQMRFSLRDDTIPVLTTKKIFWRGVVEEL 63
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
WFI G+T+ K L +K IHIW+ N SR++LD GL DR EGDLGPVYGFQWRHFGA Y
Sbjct: 64 SWFIRGNTDAKELAKKKIHIWNANGSREFLDSRGLYDRAEGDLGPVYGFQWRHFGAEYDT 123
Query: 400 MHADYTGQGFDQLLDVI 416
+DYTG+G DQL +++
Sbjct: 124 CSSDYTGKGIDQLANIL 140
>A5HEW4_WSSV (tr|A5HEW4) Thymidylate synthase OS=White spot syndrome virus PE=3
SV=1
Length = 289
Score = 184 bits (468), Expect = 1e-44, Method: Compositional matrix adjust.
Identities = 89/137 (64%), Positives = 106/137 (77%), Gaps = 1/137 (0%)
Query: 281 EFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEEL 339
E YL LV++I+ G KDDRTGTGTLS FG QMRF+LR T P+LTTKK+FWRGVVEEL
Sbjct: 4 EHQYLNLVREILERGVKKDDRTGTGTLSIFGPQMRFSLRDDTIPVLTTKKIFWRGVVEEL 63
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWFI G+T+ K L +K IHIW+ N SR++LD GL DR EGDLGPVYG QWRHFGA Y
Sbjct: 64 LWFIRGNTDAKELAKKKIHIWNANGSREFLDSRGLYDRAEGDLGPVYGSQWRHFGAEYDT 123
Query: 400 MHADYTGQGFDQLLDVI 416
+DYTG+G DQL +++
Sbjct: 124 CSSDYTGKGIDQLANIL 140
>Q29KG5_DROPS (tr|Q29KG5) Thymidylate synthase OS=Drosophila pseudoobscura
pseudoobscura GN=GA16493 PE=3 SV=1
Length = 330
Score = 184 bits (468), Expect = 1e-44, Method: Compositional matrix adjust.
Identities = 91/177 (51%), Positives = 123/177 (69%), Gaps = 2/177 (1%)
Query: 242 VSAVESHGQDNGLSSDNSYIKFEVKKFSF-LPKMVFERH-EEFLYLRLVQDIISDGNLKD 299
+A+ + DN S IK E+++ + +P ++ E + +E YL +Q II +G +
Sbjct: 4 AAAIPNLSSDNASPVKKSPIKRELEECNVEVPLLLQETNKDEQQYLDFIQYIIGNGERRI 63
Query: 300 DRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHI 359
DRT GTLS FG Q+RF++R +FPLLTTK+VF+R VVEEL+WF+ G T+ K+LQ K +HI
Sbjct: 64 DRTNVGTLSVFGSQLRFDMRLSFPLLTTKRVFFRAVVEELIWFVGGKTDAKLLQAKNVHI 123
Query: 360 WDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
WDGN++R+YLD +G DR GDLGPVYGFQWRHFGA Y DY+G+G DQL VI
Sbjct: 124 WDGNSTREYLDKLGHTDRAVGDLGPVYGFQWRHFGAEYGTCDDDYSGKGIDQLRQVI 180
>D2CLW7_9APIC (tr|D2CLW7) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 641
Score = 184 bits (467), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 88/185 (47%), Positives = 119/185 (64%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN-SYIKFEVKK-----------FSFLPKMVFERHEEFLYLRLVQDI 291
A+ S G+DN D+ Y F KK F + ++H E+ YL ++ D+
Sbjct: 309 ALTSQGKDNVDDEDDYMYFSFNNKKKKSQIMKNVEDFEIYNSIKLKQHPEYQYLNIIYDV 368
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 369 MMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWFIRGETNGNI 428
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 429 LLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGIDQ 488
Query: 412 LLDVI 416
L ++I
Sbjct: 489 LKNII 493
Score = 72.4 bits (176), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 61/221 (27%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGRK--------------------------- 105
GIG +G LPW+ S D+ +F VT ++ K
Sbjct: 38 GIGNKGILPWKCNSVDISYFSSVTTYVNEWNYKKLKYKREKYLEKDISNDKKKVDVINIA 97
Query: 106 -------NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 98 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 156
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L I++T I + +CD F P +D + FQ
Sbjct: 157 LLKK----LYYYKCFIIGGAGVYKECLERNLMKQIYLTRINNTYECDVFFPDMDENAFQI 212
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 213 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 248
>D2CLW6_9APIC (tr|D2CLW6) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 639
Score = 184 bits (467), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 88/185 (47%), Positives = 119/185 (64%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN-SYIKFEVKK-----------FSFLPKMVFERHEEFLYLRLVQDI 291
A+ S G+DN D+ Y F KK F + ++H E+ YL ++ D+
Sbjct: 307 ALTSQGKDNVDDEDDYMYFSFNNKKKKSQIMKNVEDFEIYNSIKLKQHPEYQYLNIIYDV 366
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 367 MMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWFIRGETNGNI 426
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 427 LLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGIDQ 486
Query: 412 LLDVI 416
L ++I
Sbjct: 487 LKNII 491
Score = 72.4 bits (176), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 61/221 (27%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGRK--------------------------- 105
GIG +G LPW+ S D+ +F VT ++ K
Sbjct: 38 GIGNKGILPWKCNSVDISYFSSVTTYVNEWNYKKLKYKREKYLEKDISNDKKKVDVINIA 97
Query: 106 -------NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 98 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 156
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L I++T I + +CD F P +D + FQ
Sbjct: 157 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQIYLTRINNTYECDVFFPDMDENAFQI 212
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 213 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 248
>D2CLW8_9APIC (tr|D2CLW8) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 641
Score = 184 bits (467), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 87/185 (47%), Positives = 119/185 (64%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN------------SYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDI 291
A+ S G+DN D+ S I V+ F + ++H E+ YL ++ D+
Sbjct: 309 ALTSQGKDNVDDEDDYMYFSFNNKKKKSQIMKNVEDFEIYNSIKLKQHPEYQYLNIIYDV 368
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 369 MMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWFIRGETNGNI 428
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 429 LLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGIDQ 488
Query: 412 LLDVI 416
L ++I
Sbjct: 489 LKNII 493
Score = 69.3 bits (168), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 60/221 (27%), Positives = 88/221 (39%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGRK--------------------------- 105
G+G +G LPW+ S D+ F VT ++ K
Sbjct: 38 GVGNKGILPWKCNSVDISCFSSVTTYVNEWNYKKLKYKREKYLEKDISNDKKKVDVINIA 97
Query: 106 -------NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 98 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 156
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L I++T I + +CD F P +D + FQ
Sbjct: 157 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQIYLTRINNTYECDVFFPDMDENAFQI 212
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 213 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 248
>D2CLW4_9APIC (tr|D2CLW4) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 639
Score = 184 bits (467), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 88/185 (47%), Positives = 119/185 (64%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN-SYIKFEVKK-----------FSFLPKMVFERHEEFLYLRLVQDI 291
A+ S G+DN D+ Y F KK F + ++H E+ YL ++ D+
Sbjct: 307 ALTSQGKDNVDDEDDYMYFSFNNKKKKSQIMKNVEDFEIYNSIKLKQHPEYQYLNIIYDV 366
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 367 MMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWFIRGETNGNI 426
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 427 LLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGIDQ 486
Query: 412 LLDVI 416
L ++I
Sbjct: 487 LKNII 491
Score = 72.0 bits (175), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 61/221 (27%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGRK--------------------------- 105
GIG +G LPW+ S D+ +F VT ++ K
Sbjct: 38 GIGNKGILPWKCNSVDISYFSSVTTYVNEWNYKKLKYKREKYLEKDISNDKKKVDVINIA 97
Query: 106 -------NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 98 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 156
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L I++T I + +CD F P +D + FQ
Sbjct: 157 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQIYLTRINNTYECDVFFPDMDENAFQI 212
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 213 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 248
>B7QMU1_IXOSC (tr|B7QMU1) Thymidylate synthase OS=Ixodes scapularis
GN=IscW_ISCW024938 PE=3 SV=1
Length = 287
Score = 184 bits (467), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 85/138 (61%), Positives = 105/138 (76%), Gaps = 1/138 (0%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEE 338
EE+ YL+ ++ I+ +G K DRTG GT+S FG Q R++LR T PLLTTK+VFWRGVVEE
Sbjct: 2 EEYQYLKTLKHILENGKKKKDRTGVGTMSIFGVQCRYSLRNGTMPLLTTKRVFWRGVVEE 61
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF+ GST+ K L E+GIHIWD N SR +LD +G DREEGDLGPVYGFQWRHFGA Y
Sbjct: 62 LLWFLRGSTDAKELSERGIHIWDQNGSRRFLDSLGFFDREEGDLGPVYGFQWRHFGATYR 121
Query: 399 DMHADYTGQGFDQLLDVI 416
+ H DY +G DQ+ ++
Sbjct: 122 NSHTDYGNEGVDQITRLV 139
>B4NBS5_DROWI (tr|B4NBS5) Thymidylate synthase OS=Drosophila willistoni
GN=GK18710 PE=3 SV=1
Length = 354
Score = 184 bits (467), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 82/130 (63%), Positives = 99/130 (76%)
Query: 287 LVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGS 346
L++ II G + DRT GTLS FG QMRF++R +FPLLTTK+VF+R V EELLWFI G
Sbjct: 75 LLRSIIERGETRIDRTRVGTLSIFGSQMRFDMRESFPLLTTKRVFFRAVAEELLWFIKGK 134
Query: 347 TNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTG 406
T+ K+LQ+K +HIWDGN++R++LD +G DR GDLGPVYGFQWRHFGA Y DYTG
Sbjct: 135 TDAKILQDKNVHIWDGNSTREFLDNLGFTDRAVGDLGPVYGFQWRHFGAEYRTCQDDYTG 194
Query: 407 QGFDQLLDVI 416
QG DQL VI
Sbjct: 195 QGVDQLRQVI 204
>D2CLX6_9APIC (tr|D2CLX6) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 622
Score = 184 bits (467), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 88/185 (47%), Positives = 119/185 (64%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN-SYIKFEVKK-----------FSFLPKMVFERHEEFLYLRLVQDI 291
A+ S G+DN D+ Y F KK F + ++H E+ YL ++ D+
Sbjct: 298 ALTSQGKDNVDDEDDYMYFSFNNKKKKSQIMKNVEDFEIYNSIKLKQHPEYQYLNIIYDV 357
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 358 MMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWFIRGETNGNI 417
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 418 LLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGIDQ 477
Query: 412 LLDVI 416
L ++I
Sbjct: 478 LKNII 482
Score = 74.7 bits (182), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 61/221 (27%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGRK--------------------------- 105
GIG +G LPW+ S D+ +F VT ++ K
Sbjct: 29 GIGNKGILPWKCNSVDISYFSSVTTYVNEWNYKKLKYKREKYLEKDISNDKKKVDVINIA 88
Query: 106 -------NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L I++T I + +CD F P +D + FQ
Sbjct: 148 LLKK----LYYHKCFIIGGAGVYKECLERNLIKQIYLTRINNTYECDVFFPDMDENAFQI 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>D2CLX8_9APIC (tr|D2CLX8) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 622
Score = 184 bits (466), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 87/185 (47%), Positives = 119/185 (64%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN------------SYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDI 291
A+ S G+DN D+ S I V+ F + ++H E+ YL ++ D+
Sbjct: 298 ALTSQGKDNVDDEDDYMYFSFNNKKKKSQIMKNVEDFEIYNSIKLKQHPEYQYLNIIYDV 357
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 358 MMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWFIRGETNGNI 417
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 418 LLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGIDQ 477
Query: 412 LLDVI 416
L ++I
Sbjct: 478 LKNII 482
Score = 72.0 bits (175), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 61/221 (27%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGRK--------------------------- 105
GIG +G LPW+ S D+ +F VT ++ K
Sbjct: 29 GIGNKGILPWKCNSVDISYFSSVTTYVNEWNYKKLKYKREKYLEKDISNDKKKVDVINIA 88
Query: 106 -------NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L I++T I + +CD F P +D + FQ
Sbjct: 148 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQIYLTRINNTYECDVFFPDMDENAFQI 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>D2CLY1_9APIC (tr|D2CLY1) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 622
Score = 184 bits (466), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 87/185 (47%), Positives = 119/185 (64%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN------------SYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDI 291
A+ S G+DN D+ S I V+ F + ++H E+ YL ++ D+
Sbjct: 298 ALTSQGKDNVDDEDDYMYFSFNNKKKKSQIMKNVEDFEIYNSIKLKQHPEYQYLNIIYDV 357
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 358 MMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWFIRGETNGNI 417
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 418 LLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGIDQ 477
Query: 412 LLDVI 416
L ++I
Sbjct: 478 LKNII 482
Score = 72.0 bits (175), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 61/221 (27%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGRK--------------------------- 105
GIG +G LPW+ S D+ +F VT ++ K
Sbjct: 29 GIGNKGILPWKCNSVDISYFSSVTTYVNEWNYKKLKYKREKYLEKDISNDKKKVDVINIA 88
Query: 106 -------NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L I++T I + +CD F P +D + FQ
Sbjct: 148 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQIYLTRINNTYECDVFFPDMDENAFQI 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>B4NXB1_DROYA (tr|B4NXB1) Thymidylate synthase OS=Drosophila yakuba GN=GE14974
PE=3 SV=1
Length = 321
Score = 184 bits (466), Expect = 2e-44, Method: Compositional matrix adjust.
Identities = 81/137 (59%), Positives = 106/137 (77%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL L++ II++G + DRT GTLS FG QMRF++R++FPLLTTK+VF+R V EEL
Sbjct: 35 DEMQYLDLLRQIIANGEQRMDRTQVGTLSLFGSQMRFDMRQSFPLLTTKRVFFRAVAEEL 94
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWF++G T+ K+LQ K +HIWDGN++R++LD +G +R GDLGPVYGFQWRHFGA Y
Sbjct: 95 LWFVAGKTDAKLLQAKNVHIWDGNSTREFLDKLGFTERAVGDLGPVYGFQWRHFGAEYAT 154
Query: 400 MHADYTGQGFDQLLDVI 416
DY+G+G DQL VI
Sbjct: 155 CDDDYSGKGIDQLRQVI 171
>Q4PBV6_USTMA (tr|Q4PBV6) Thymidylate synthase OS=Ustilago maydis GN=UM02407.1
PE=3 SV=1
Length = 554
Score = 183 bits (465), Expect = 3e-44, Method: Compositional matrix adjust.
Identities = 90/142 (63%), Positives = 104/142 (73%), Gaps = 3/142 (2%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQ--MRFNLRR-TFPLLTTKKVFWRG 334
+HEE YL LVQ +IS G + DRTGTGTL+ F Q +RF+L T PLLTTK+VF+RG
Sbjct: 255 KHEESQYLELVQRVISTGESRPDRTGTGTLALFAPQPSLRFDLTNGTLPLLTTKRVFFRG 314
Query: 335 VVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFG 394
V+EELLWF+ G T+ K+L EK +HIWDGN SR +LD GL R EGDLGPVYGFQWRHFG
Sbjct: 315 VLEELLWFVGGKTDAKLLTEKSVHIWDGNGSRAFLDSRGLSHRREGDLGPVYGFQWRHFG 374
Query: 395 ARYTDMHADYTGQGFDQLLDVI 416
A Y D DY GQG DQL VI
Sbjct: 375 ATYKDCDTDYAGQGVDQLASVI 396
>D2CLX1_9APIC (tr|D2CLX1) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 620
Score = 183 bits (464), Expect = 3e-44, Method: Compositional matrix adjust.
Identities = 87/185 (47%), Positives = 118/185 (63%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN-SYIKFEVKK-----------FSFLPKMVFERHEEFLYLRLVQDI 291
+ S G+DN D+ Y F KK F + ++H E+ YL ++ D+
Sbjct: 296 TLTSQGKDNVDEEDDYMYFSFNNKKKKSQIGKNAEDFEIYNTIKLKQHPEYQYLNIIYDV 355
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 356 MINGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFIRGIIEELLWFIRGETNGNI 415
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 416 LLNKNVRIWEANGTREFLDNRNLFDREANDLGPIYGFQWRHFGAEYTNMYDNYDNKGIDQ 475
Query: 412 LLDVI 416
L ++I
Sbjct: 476 LKNII 480
Score = 71.2 bits (173), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 59/221 (26%), Positives = 90/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSD------------------------------- 101
GIG +G LPW+ S D+ +F VT ++
Sbjct: 29 GIGNKGILPWKYNSVDISYFSSVTTYVNEWNYNKLKYKREKYLEKDISNDKKKVDVINIA 88
Query: 102 ---SGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
+N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L +++T I + +CD F P++D + FQ
Sbjct: 148 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQVYLTRINNTYECDVFFPEMDKNTFQI 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>C4YIJ5_CANAL (tr|C4YIJ5) Thymidylate synthase OS=Candida albicans GN=CAWG_04271
PE=3 SV=1
Length = 315
Score = 183 bits (464), Expect = 4e-44, Method: Compositional matrix adjust.
Identities = 88/138 (63%), Positives = 106/138 (76%), Gaps = 2/138 (1%)
Query: 281 EFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFWRGVVEE 338
E YL L + II +G + DRTGTGT S F Q+RF+L TFPLLTTKKVF +G++ E
Sbjct: 9 EQAYLDLCKRIIDEGEHRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKKVFSKGIIHE 68
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF++GST+ K+L EKG+ IW+GN SR++LD +GL R EGDLGPVYGFQWRHFGA Y
Sbjct: 69 LLWFVAGSTDAKILSEKGVKIWEGNGSREFLDKLGLTHRREGDLGPVYGFQWRHFGAEYK 128
Query: 399 DMHADYTGQGFDQLLDVI 416
D +DYTGQGFDQL DVI
Sbjct: 129 DCDSDYTGQGFDQLQDVI 146
>B7P7E2_IXOSC (tr|B7P7E2) Thymidylate synthase (Fragment) OS=Ixodes scapularis
GN=IscW_ISCW000960 PE=3 SV=1
Length = 301
Score = 182 bits (463), Expect = 4e-44, Method: Compositional matrix adjust.
Identities = 87/151 (57%), Positives = 108/151 (71%), Gaps = 1/151 (0%)
Query: 267 KFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLL 325
+ + +V H+E+ YL + I+ +G K DRTGTGT+S FG Q R++L T PLL
Sbjct: 7 EIGYQAALVACSHDEYQYLDTLAHILKNGRQKGDRTGTGTISIFGAQCRYSLADGTMPLL 66
Query: 326 TTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPV 385
TTK+VFWRGVVEELLWF+ GSTN K L E+G+ IWDGN SR +LD +G DREEGDLGPV
Sbjct: 67 TTKRVFWRGVVEELLWFLRGSTNAKELSERGVRIWDGNGSRQFLDSLGFVDREEGDLGPV 126
Query: 386 YGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
YGFQWRHFGA Y M DY +G DQ+ ++I
Sbjct: 127 YGFQWRHFGAPYRTMRTDYGDEGVDQIKNLI 157
>D2CLX0_9APIC (tr|D2CLX0) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 620
Score = 182 bits (463), Expect = 5e-44, Method: Compositional matrix adjust.
Identities = 87/185 (47%), Positives = 118/185 (63%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN-SYIKFEVKK-----------FSFLPKMVFERHEEFLYLRLVQDI 291
+ S G+DN D+ Y F KK F + ++H E+ YL ++ D+
Sbjct: 296 TLTSQGKDNVDEEDDYMYFSFNNKKKKSQIGKNAEDFEIYNTIKLKQHPEYQYLNIIYDV 355
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 356 MINGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFIRGIIEELLWFIRGETNGNI 415
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 416 LLNKNVRIWEANGTREFLDNRNLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYDNKGIDQ 475
Query: 412 LLDVI 416
L ++I
Sbjct: 476 LKNII 480
Score = 67.4 bits (163), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 58/221 (26%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSD------------------------------- 101
GIG +G LPW+ S D+ +F VT ++
Sbjct: 29 GIGNKGILPWKYNSVDISYFSSVTTYVNEWNYNKLKYKREKYLEKDISNDKKKVDVINIA 88
Query: 102 ---SGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
+N V+MGR +WESI ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESILKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L +++T I + +CD F P++D + FQ
Sbjct: 148 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQVYLTRINNTYECDVFFPEMDKNTFQI 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>B7QLC8_IXOSC (tr|B7QLC8) Thymidylate synthase OS=Ixodes scapularis
GN=IscW_ISCW014062 PE=3 SV=1
Length = 287
Score = 182 bits (463), Expect = 5e-44, Method: Compositional matrix adjust.
Identities = 84/138 (60%), Positives = 105/138 (76%), Gaps = 1/138 (0%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEE 338
EE+ YL+ ++ I+ +G K+DRTG GT+ FG Q R++LR T PLLTTK+VFWRGVVEE
Sbjct: 2 EEYQYLKTLKHILENGKKKEDRTGVGTMLIFGVQCRYSLRNGTMPLLTTKRVFWRGVVEE 61
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF+ GST+ K L E+GIHIWD N SR +LD +G DREEGDLGPVYGFQWRHFGA Y
Sbjct: 62 LLWFLRGSTDAKELSERGIHIWDQNGSRRFLDSLGFFDREEGDLGPVYGFQWRHFGATYR 121
Query: 399 DMHADYTGQGFDQLLDVI 416
+ H DY +G DQ+ ++
Sbjct: 122 NSHTDYGNEGVDQITRLV 139
>D2CLX2_9APIC (tr|D2CLX2) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 620
Score = 182 bits (463), Expect = 6e-44, Method: Compositional matrix adjust.
Identities = 87/185 (47%), Positives = 118/185 (63%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN-SYIKFEVKK-----------FSFLPKMVFERHEEFLYLRLVQDI 291
+ S G+DN D+ Y F KK F + ++H E+ YL ++ D+
Sbjct: 296 TLTSQGKDNVDEEDDYMYFSFNNKKKKSQIGKNAEDFEIYNTIKLKQHPEYQYLNIIYDV 355
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 356 MINGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFIRGIIEELLWFIRGETNGNI 415
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 416 LLNKNVRIWEANGTREFLDNRNLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYDNKGIDQ 475
Query: 412 LLDVI 416
L ++I
Sbjct: 476 LKNII 480
Score = 71.2 bits (173), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 59/221 (26%), Positives = 90/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSD------------------------------- 101
GIG +G LPW+ S D+ +F VT ++
Sbjct: 29 GIGNKGILPWKYNSVDISYFSSVTTYVNEWNYDKLKYKREKYLEKDISNDKKKVDVINMA 88
Query: 102 ---SGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
+N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L +++T I + +CD F P++D + FQ
Sbjct: 148 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQVYLTRINNTYECDVFFPEMDKNTFQI 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>D2CLX4_9APIC (tr|D2CLX4) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 620
Score = 182 bits (462), Expect = 6e-44, Method: Compositional matrix adjust.
Identities = 87/185 (47%), Positives = 118/185 (63%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN-SYIKFEVKK-----------FSFLPKMVFERHEEFLYLRLVQDI 291
+ S G+DN D+ Y F KK F + ++H E+ YL ++ D+
Sbjct: 296 TLTSQGKDNVDEEDDYMYFSFNNKKKKSQIGKNAEDFEIYNTIKLKQHPEYQYLNIIYDV 355
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 356 MINGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFIRGIIEELLWFIRGETNGNI 415
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 416 LLNKNVRIWEANGTREFLDNRNLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYDNKGIDQ 475
Query: 412 LLDVI 416
L ++I
Sbjct: 476 LKNII 480
Score = 71.2 bits (173), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 59/221 (26%), Positives = 90/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSD------------------------------- 101
GIG +G LPW+ S D+ +F VT ++
Sbjct: 29 GIGNKGILPWKYNSVDISYFSSVTTYVNEWNYNKLKYKREKYLEKDISNDKKKVDVINIA 88
Query: 102 ---SGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
+N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L +++T I + +CD F P++D + FQ
Sbjct: 148 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQVYLTRINNTYECDVFFPEMDKNTFQV 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>D2CLY0_9APIC (tr|D2CLY0) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 622
Score = 182 bits (462), Expect = 6e-44, Method: Compositional matrix adjust.
Identities = 81/158 (51%), Positives = 110/158 (69%)
Query: 259 SYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNL 318
S I V+ F + ++H E+ YL ++ D++ +GN +DDRTG G LSKFG M++NL
Sbjct: 325 SQIMKNVEDFEIYNSIKLKQHPEYQYLNIIYDVMMNGNKQDDRTGVGVLSKFGYMMKYNL 384
Query: 319 RRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDRE 378
FPLLTTKK+F RG++EELLWFI G TN +L K + IW+ N +R++LD L DRE
Sbjct: 385 AEYFPLLTTKKLFVRGIIEELLWFIRGETNGNILLNKNVRIWEANGTREFLDNRKLFDRE 444
Query: 379 EGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
DLGP+YGFQWRHFGA YT+M+ +Y +G DQL ++I
Sbjct: 445 VNDLGPIYGFQWRHFGAEYTNMYDNYENKGIDQLKNII 482
Score = 72.0 bits (175), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 61/221 (27%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGRK--------------------------- 105
GIG +G LPW+ S D+ +F VT ++ K
Sbjct: 29 GIGNKGILPWKCNSVDISYFSSVTTYVNEWNYKKLKYKREKYLEKDISNDKKKVDVINIA 88
Query: 106 -------NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L I++T I + +CD F P +D + FQ
Sbjct: 148 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQIYLTRINNTYECDVFFPDMDENTFQI 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>D2CLX9_9APIC (tr|D2CLX9) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 622
Score = 182 bits (462), Expect = 6e-44, Method: Compositional matrix adjust.
Identities = 87/185 (47%), Positives = 119/185 (64%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN-SYIKFEVKK-----------FSFLPKMVFERHEEFLYLRLVQDI 291
A+ S G+DN D+ Y F KK F + ++H ++ YL ++ D+
Sbjct: 298 ALTSQGKDNVDDEDDYMYFSFNNKKKKSQIMKNVEDFEIYNSIKLKQHPKYQYLNIIYDV 357
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 358 MMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWFIRGETNGNI 417
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 418 LLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGIDQ 477
Query: 412 LLDVI 416
L ++I
Sbjct: 478 LKNII 482
Score = 71.6 bits (174), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 61/221 (27%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGRK--------------------------- 105
GIG +G LPW+ S D+ +F VT ++ K
Sbjct: 29 GIGNKGILPWKCNSVDISYFSSVTTYVNEWNYKKLKYKREKYLEKDISNDKKKVDVINIA 88
Query: 106 -------NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L I++T I + +CD F P +D + FQ
Sbjct: 148 LLKK----LYYYKCFIIGGAGVYKEYLERNLIKQIYLTRINNTYECDVFFPDMDENAFQI 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>D2CLX3_9APIC (tr|D2CLX3) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 620
Score = 182 bits (462), Expect = 6e-44, Method: Compositional matrix adjust.
Identities = 87/182 (47%), Positives = 117/182 (64%), Gaps = 12/182 (6%)
Query: 247 SHGQDNGLSSDN-SYIKFEVKK-----------FSFLPKMVFERHEEFLYLRLVQDIISD 294
S G+DN D+ Y F KK F + ++H E+ YL ++ D++ +
Sbjct: 299 SQGKDNVDEEDDYMYFSFNNKKKKSQIGKNAEDFEIYNTIKLKQHPEYQYLNIIYDVMIN 358
Query: 295 GNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQE 354
GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +L
Sbjct: 359 GNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFIRGIIEELLWFIGGETNGNILLN 418
Query: 355 KGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLD 414
K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQL +
Sbjct: 419 KNVRIWEANGTREFLDNRNLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYDNKGIDQLKN 478
Query: 415 VI 416
+I
Sbjct: 479 II 480
Score = 69.3 bits (168), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 59/221 (26%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSD------------------------------- 101
GIG +G LPW+ S D+ +F VT ++
Sbjct: 29 GIGNKGILPWKYNSVDISYFSSVTTYVNEWNYNKLKYKREKYLEKDISNDKKKVDVINIA 88
Query: 102 ---SGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
+N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L +++T I + +CD F P +D + FQ
Sbjct: 148 LLKK----LYYYKRFIIGGAGVYKECLERNLIKQVYLTRINNTYECDVFFPGMDKNTFQI 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>B9WBH8_CANDC (tr|B9WBH8) Thymidylate synthase OS=Candida dubliniensis (strain
CD36 / CBS 7987 / NCPF 3949 / NRRL Y-17841)
GN=CD36_19690 PE=3 SV=1
Length = 315
Score = 182 bits (462), Expect = 7e-44, Method: Compositional matrix adjust.
Identities = 87/138 (63%), Positives = 106/138 (76%), Gaps = 2/138 (1%)
Query: 281 EFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFWRGVVEE 338
E YL L + II +G + DRTGTGT S F Q+RF+L TFPLLTTKKVF +G++ E
Sbjct: 9 EQAYLDLCKKIIDEGEHRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKKVFSKGIIHE 68
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF++GST+ K+L EKG+ IW+GN SR++LD +GL R EGDLGPVYGFQWRHFGA Y
Sbjct: 69 LLWFVAGSTDAKILSEKGVKIWEGNGSREFLDKLGLTHRREGDLGPVYGFQWRHFGAEYK 128
Query: 399 DMHADYTGQGFDQLLDVI 416
D +DY+GQGFDQL DVI
Sbjct: 129 DCDSDYSGQGFDQLQDVI 146
>D2CLW9_9APIC (tr|D2CLW9) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 637
Score = 182 bits (462), Expect = 7e-44, Method: Compositional matrix adjust.
Identities = 87/185 (47%), Positives = 118/185 (63%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN-SYIKFEVKK-----------FSFLPKMVFERHEEFLYLRLVQDI 291
+ S G+DN D+ Y F KK F + ++H E+ YL ++ D+
Sbjct: 305 TLTSQGKDNVDEEDDYMYFSFNNKKKKSQIGKNAEDFEIYNTIKLKQHPEYQYLNIIYDV 364
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F RG++EELLWFI G TN +
Sbjct: 365 MINGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFIRGIIEELLWFIRGETNGNI 424
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 425 LLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYDNKGIDQ 484
Query: 412 LLDVI 416
L ++I
Sbjct: 485 LKNII 489
Score = 71.6 bits (174), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 59/221 (26%), Positives = 90/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSD------------------------------- 101
GIG +G LPW+ S D+ +F VT ++
Sbjct: 38 GIGNKGILPWKYNSVDISYFSSVTTYVNEWNYNKLKYKREKYLEKDISNDKKKVDVINIA 97
Query: 102 ---SGRKNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
+N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 98 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 156
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L +++T I + +CD F P++D + FQ
Sbjct: 157 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQVYLTRINNTYECDVFFPEMDKNTFQI 212
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 213 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 248
>B5RT83_DEBHA (tr|B5RT83) Thymidylate synthase OS=Debaryomyces hansenii
GN=DEHA2C06094g PE=3 SV=1
Length = 316
Score = 182 bits (461), Expect = 8e-44, Method: Compositional matrix adjust.
Identities = 90/138 (65%), Positives = 103/138 (74%), Gaps = 2/138 (1%)
Query: 281 EFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFWRGVVEE 338
E YL L + II++G + DRTGTGT S F Q+RFNL TFPLLTTKKVF R ++ E
Sbjct: 9 EQTYLDLCERIINEGEHRPDRTGTGTKSLFAPPQLRFNLSDDTFPLLTTKKVFSRAIIHE 68
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF+ G T+ K L EKG+ IW+GN SR+YLD IGL DR EGDLGPVYGFQWRHFGA Y
Sbjct: 69 LLWFVQGCTDAKKLSEKGVKIWEGNGSREYLDSIGLTDRREGDLGPVYGFQWRHFGAEYK 128
Query: 399 DMHADYTGQGFDQLLDVI 416
D ADY+GQG DQL DVI
Sbjct: 129 DCDADYSGQGVDQLQDVI 146
>Q8WYK3_HUMAN (tr|Q8WYK3) Thymidylate synthase OS=Homo sapiens GN=TS PE=2 SV=1
Length = 279
Score = 182 bits (461), Expect = 9e-44, Method: Compositional matrix adjust.
Identities = 84/125 (67%), Positives = 95/125 (76%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEE 338
H E YL +Q I+ G KDDRTGTGTLS FG Q R++LR FPLLTTK+VFW+GV+EE
Sbjct: 28 HGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEE 87
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWFI GSTN K L KG+ IWD N SRD+LD +G REEGDLGPVYGFQWRHFGA Y
Sbjct: 88 LLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 147
Query: 399 DMHAD 403
DM +D
Sbjct: 148 DMESD 152
>C4R672_PICPG (tr|C4R672) Thymidylate synthase OS=Pichia pastoris (strain GS115)
GN=PAS_chr3_0996 PE=3 SV=1
Length = 298
Score = 182 bits (461), Expect = 9e-44, Method: Compositional matrix adjust.
Identities = 91/145 (62%), Positives = 104/145 (71%), Gaps = 2/145 (1%)
Query: 274 MVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVF 331
M EE YL L II +G + DRTGTGT S F Q+RFNLR FPLLTTKK F
Sbjct: 1 MTMTNQEEQAYLDLCVRIIKEGEHRPDRTGTGTYSLFAPPQLRFNLRDGQFPLLTTKKTF 60
Query: 332 WRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWR 391
+G++ ELLWF+ G T+ K L EKG+ IW+GN SR+YLD +GLKDRE GDLGPVYGFQWR
Sbjct: 61 VKGIIHELLWFVEGCTDGKKLSEKGVRIWEGNGSREYLDSLGLKDREVGDLGPVYGFQWR 120
Query: 392 HFGARYTDMHADYTGQGFDQLLDVI 416
HFGA+Y D DYTGQGFDQL VI
Sbjct: 121 HFGAQYKDCKTDYTGQGFDQLSRVI 145
>B4Q910_DROSI (tr|B4Q910) Thymidylate synthase OS=Drosophila simulans GN=GD22790
PE=3 SV=1
Length = 321
Score = 181 bits (460), Expect = 1e-43, Method: Compositional matrix adjust.
Identities = 82/137 (59%), Positives = 105/137 (76%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL L++ II++G + DRT GTLS FG QMRF++R +FPLLTTK+VF+R V EEL
Sbjct: 35 DEMNYLDLLRHIIANGEQRMDRTEVGTLSVFGSQMRFDMRNSFPLLTTKRVFFRAVAEEL 94
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWF++G T+ K+LQ K +HIWDGN+SR++LD +G R GDLGPVYGFQWRHFGA+Y
Sbjct: 95 LWFVAGKTDAKLLQAKNVHIWDGNSSREFLDKMGFTGRAVGDLGPVYGFQWRHFGAQYGT 154
Query: 400 MHADYTGQGFDQLLDVI 416
DY+G+G DQL VI
Sbjct: 155 CDDDYSGKGIDQLRQVI 171
>Q541C9_DROME (tr|Q541C9) Thymidylate synthase OS=Drosophila melanogaster GN=Ts
PE=2 SV=1
Length = 321
Score = 181 bits (460), Expect = 1e-43, Method: Compositional matrix adjust.
Identities = 82/137 (59%), Positives = 105/137 (76%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL L++ II++G + DRT GTLS FG QMRF++R +FPLLTTK+VF+R V EEL
Sbjct: 35 DEMHYLDLLRHIIANGEQRMDRTEVGTLSVFGSQMRFDMRNSFPLLTTKRVFFRAVAEEL 94
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWF++G T+ K+LQ K +HIWDGN+SR++LD +G R GDLGPVYGFQWRHFGA+Y
Sbjct: 95 LWFVAGKTDAKLLQAKNVHIWDGNSSREFLDKMGFTGRAVGDLGPVYGFQWRHFGAQYGT 154
Query: 400 MHADYTGQGFDQLLDVI 416
DY+G+G DQL VI
Sbjct: 155 CDDDYSGKGIDQLRQVI 171
>Q9YVK4_MSEPV (tr|Q9YVK4) Thymidylate synthase OS=Melanoplus sanguinipes
entomopoxvirus GN=MSV238 PE=3 SV=1
Length = 292
Score = 181 bits (459), Expect = 1e-43, Method: Compositional matrix adjust.
Identities = 79/137 (57%), Positives = 102/137 (74%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E+ YL+ + +I+S+G + +RTG T + +G M++ L +FPL TTK +FWRG+VEEL
Sbjct: 7 DEYQYLKGISEILSNGRITKNRTGVDTKTVYGLTMKYKLDDSFPLFTTKSMFWRGIVEEL 66
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWFISGSTN +L+ KGIHIWD N S Y+ G DR+EGDLGPVYGFQWRHFGA+Y D
Sbjct: 67 LWFISGSTNTNILKNKGIHIWDENGSLKYIKKRGFNDRKEGDLGPVYGFQWRHFGAKYID 126
Query: 400 MHADYTGQGFDQLLDVI 416
M +YT QGFDQL +I
Sbjct: 127 MDTNYTNQGFDQLTHII 143
>B3MLB9_DROAN (tr|B3MLB9) Thymidylate synthase OS=Drosophila ananassae GN=GF14907
PE=3 SV=1
Length = 340
Score = 181 bits (459), Expect = 1e-43, Method: Compositional matrix adjust.
Identities = 85/140 (60%), Positives = 104/140 (74%)
Query: 277 ERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVV 336
E +E YL L++ II+ G + DRT GTLS FG QMRF+LR FPLLTTK+VF+R V
Sbjct: 51 ENADEKQYLNLLRSIINTGERRMDRTEVGTLSIFGSQMRFSLRGCFPLLTTKRVFFRAVA 110
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWF++G T+ K+LQ K +HIWDGN++R++LD +G DR GDLGPVYGFQWRHFGA
Sbjct: 111 EELLWFVAGKTDAKLLQAKNVHIWDGNSTREFLDKLGHTDRAVGDLGPVYGFQWRHFGAE 170
Query: 397 YTDMHADYTGQGFDQLLDVI 416
YT DY G+G DQL VI
Sbjct: 171 YTTCDDDYRGKGIDQLKHVI 190
>D2CLX7_9APIC (tr|D2CLX7) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 622
Score = 181 bits (459), Expect = 2e-43, Method: Compositional matrix adjust.
Identities = 86/185 (46%), Positives = 118/185 (63%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN------------SYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDI 291
A+ S G+DN D+ S I V+ F + ++H E+ YL ++ D+
Sbjct: 298 ALTSQGKDNVDDEDDYMYFSFNNKKKKSQIMKNVEDFEIYNSIKLKQHPEYQYLNIIYDV 357
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F R ++EELLWFI G TN +
Sbjct: 358 MMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVREIIEELLWFIRGETNGNI 417
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 418 LLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGIDQ 477
Query: 412 LLDVI 416
L ++I
Sbjct: 478 LKNII 482
Score = 72.0 bits (175), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 61/221 (27%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGRK--------------------------- 105
GIG +G LPW+ S D+ +F VT ++ K
Sbjct: 29 GIGNKGILPWKCNSVDISYFSSVTTYVNEWNYKKLKYKREKYLEKDISNDKKKVDVINIA 88
Query: 106 -------NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L I++T I + +CD F P +D + FQ
Sbjct: 148 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQIYLTRINNTYECDVFFPDMDENAFQI 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>D2CLX5_9APIC (tr|D2CLX5) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium ovale GN=DHFR-TS PE=4 SV=1
Length = 622
Score = 181 bits (458), Expect = 2e-43, Method: Compositional matrix adjust.
Identities = 86/185 (46%), Positives = 118/185 (63%), Gaps = 12/185 (6%)
Query: 244 AVESHGQDNGLSSDN------------SYIKFEVKKFSFLPKMVFERHEEFLYLRLVQDI 291
A+ S G+DN D+ S I V+ F + ++H E+ YL ++ D+
Sbjct: 298 ALTSQGKDNVDDEDDYMYFSFNNKKKKSQIMKNVEDFEIYNSIKLKQHPEYQYLNIIYDV 357
Query: 292 ISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEELLWFISGSTNCKV 351
+ +GN +DDRTG G LSKFG M++NL FPLLTTKK+F G++EELLWFI G TN +
Sbjct: 358 MMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVGGIIEELLWFIRGETNGNI 417
Query: 352 LQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQ 411
L K + IW+ N +R++LD L DRE DLGP+YGFQWRHFGA YT+M+ +Y +G DQ
Sbjct: 418 LLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGIDQ 477
Query: 412 LLDVI 416
L ++I
Sbjct: 478 LKNII 482
Score = 72.0 bits (175), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 61/221 (27%), Positives = 89/221 (40%), Gaps = 45/221 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGRK--------------------------- 105
GIG +G LPW+ S D+ +F VT ++ K
Sbjct: 29 GIGNKGILPWKCNSVDISYFSSVTTYVNEWNYKKLKYKREKYLEKDISNDKKKVDVINIA 88
Query: 106 -------NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXX 158
N V+MGR +WESIP ++PL R+NVVL+ + + E++ I
Sbjct: 89 PISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKE-DVKEDIFIMKSMDEVLL 147
Query: 159 XXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQP 218
L K FIIGG + +E L I++T I + +CD F P +D + FQ
Sbjct: 148 LLKK----LYYYKCFIIGGAGVYKECLERNLIKQIYLTRINNTYECDVFFPDMDENAFQI 203
Query: 219 WYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
S N F Y R + Q++G SS+ S
Sbjct: 204 TSVSEVYSSNGTTLDFLIYSRKKKDT-----QNDGDSSEGS 239
>A1Y2B9_LEITR (tr|A1Y2B9) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Leishmania tropica PE=3 SV=1
Length = 195
Score = 181 bits (458), Expect = 2e-43, Method: Compositional matrix adjust.
Identities = 90/165 (54%), Positives = 113/165 (68%), Gaps = 2/165 (1%)
Query: 254 LSSDNSYIKFEVKKFSF-LPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC 312
L+S K E + F + K V HEE YL L+ I+ G +K+DRTG GT+S FG
Sbjct: 20 LASSQGRRKSEAEGLEFEICKYVPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGA 79
Query: 313 QMRFNLR-RTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDG 371
QMRF+LR PLLTTK+VFWRGV EELLWF+ G TN ++L +K IHIWDGN SR++LD
Sbjct: 80 QMRFSLRGNRLPLLTTKRVFWRGVCEELLWFLRGETNARLLADKDIHIWDGNGSREFLDS 139
Query: 372 IGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GL + +E DLGPVYGFQWRHFGA Y A+Y G+G DQ+ ++
Sbjct: 140 RGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIRFIV 184
>Q8MVZ9_9EUKA (tr|Q8MVZ9) Bifunctional dihydrofolate reductase-thymidylate
synthase (Fragment) OS=Cercomonas longicauda GN=DHFR-TS
PE=4 SV=1
Length = 314
Score = 180 bits (457), Expect = 2e-43, Method: Compositional matrix adjust.
Identities = 118/316 (37%), Positives = 173/316 (54%), Gaps = 42/316 (13%)
Query: 109 IMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLS 168
+MGRKTW+S+ +PL R+N+VL+R G F T +NVV+C
Sbjct: 1 VMGRKTWDSL---KKPLIQRVNIVLSRQG-FSHPT-DNVVVCSSLERAFEHARMRH---P 52
Query: 169 IEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVEN 228
++VF+IGG +I R+++ I++T + F+P+ + F S FP
Sbjct: 53 TKRVFVIGGEEIYRQTIAH--AQRIYLTRV--------FLPESRTPHFD---SYFP---- 95
Query: 229 NVRYCFATYVRVRVSAVESHGQDNGLSSDNSYIKFEVKKF-SFLPKMVF------ERHEE 281
R + + R+ S +E + S I + +++ S +P V EE
Sbjct: 96 -YRDLQSHFSRILSSDLEFQPE--------SGIGWRFEEWTSCIPDSVTADNVGNNNKEE 146
Query: 282 FLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEELL 340
Y+ L++ I G ++ DRTG G FG M+F+L PLLT +K+FW+GVVEELL
Sbjct: 147 SEYIDLIRRIRDQGEIRTDRTGVGIKCVFGNMMKFSLENGQIPLLTIRKIFWKGVVEELL 206
Query: 341 WFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTDM 400
W + G T+ + L+EKG++IW N SR+ LD +G+ DRE GDLGP+YG+QWRH GA YT
Sbjct: 207 WMLRGKTHSRDLEEKGVNIWRANGSREALDRLGMVDREVGDLGPIYGWQWRHSGAXYTTA 266
Query: 401 HADYTGQGFDQLLDVI 416
H DY+G G DQ+ DVI
Sbjct: 267 HTDYSGFGVDQIKDVI 282
>C5M729_CANTT (tr|C5M729) Thymidylate synthase OS=Candida tropicalis (strain ATCC
MYA-3404 / T1) GN=CTRG_01661 PE=3 SV=1
Length = 303
Score = 180 bits (456), Expect = 3e-43, Method: Compositional matrix adjust.
Identities = 87/138 (63%), Positives = 105/138 (76%), Gaps = 2/138 (1%)
Query: 281 EFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFWRGVVEE 338
E YL L + II +G + DRTGTGT S F Q+RF+L TFPLLTTKKVF +G++ E
Sbjct: 9 EQAYLDLCERIIKEGEHRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKKVFSKGIIHE 68
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWFI+GST+ K+L KG+ IW+GN SR++LD +GL R EGDLGPVYGFQWRHFGA Y
Sbjct: 69 LLWFIAGSTDAKILTNKGVKIWEGNGSREFLDKLGLTHRREGDLGPVYGFQWRHFGAEYK 128
Query: 399 DMHADYTGQGFDQLLDVI 416
D ADYTGQG+DQL D+I
Sbjct: 129 DCDADYTGQGYDQLQDII 146
>B7G430_PHATR (tr|B7G430) Thymidylate synthase (Fragment) OS=Phaeodactylum
tricornutum CCAP 1055/1 GN=PHATRDRAFT_2087 PE=3 SV=1
Length = 217
Score = 180 bits (456), Expect = 4e-43, Method: Compositional matrix adjust.
Identities = 89/138 (64%), Positives = 102/138 (73%), Gaps = 1/138 (0%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRR-TFPLLTTKKVFWRGVVEE 338
EE YL L + I+ G + DRTGTGTLS+FG QMRF+LR T PLLTTK+VFWRGV EE
Sbjct: 3 EERQYLDLCRHILDHGVHRGDRTGTGTLSQFGTQMRFSLRDGTLPLLTTKRVFWRGVAEE 62
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF++G+TN L K I IWDGN S D+LD GL RE GDLGPVYGFQWRHFGA Y
Sbjct: 63 LLWFVAGNTNANDLAAKDIRIWDGNGSPDFLDSWGLGHREVGDLGPVYGFQWRHFGATYG 122
Query: 399 DMHADYTGQGFDQLLDVI 416
+H DYTG+G DQL + I
Sbjct: 123 TIHDDYTGKGVDQLAECI 140
>A5DTE4_LODEL (tr|A5DTE4) Thymidylate synthase OS=Lodderomyces elongisporus
GN=LELG_00630 PE=3 SV=1
Length = 312
Score = 179 bits (455), Expect = 4e-43, Method: Compositional matrix adjust.
Identities = 87/138 (63%), Positives = 106/138 (76%), Gaps = 2/138 (1%)
Query: 281 EFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFWRGVVEE 338
E YL L + II++G + DRTGTGT S F Q+RF+L TFPLLTTK+VF +G++ E
Sbjct: 9 EQAYLDLCERIINEGEHRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKRVFSKGIIHE 68
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWFI+GST+ K+L +KG+ IW+GN R++LD +GL R EGDLGPVYGFQWRHFGA Y
Sbjct: 69 LLWFIAGSTDAKILSDKGVKIWEGNGLREFLDKLGLTHRREGDLGPVYGFQWRHFGAEYK 128
Query: 399 DMHADYTGQGFDQLLDVI 416
D ADYTGQGFDQL DVI
Sbjct: 129 DCDADYTGQGFDQLQDVI 146
>A1Y2C0_LEITR (tr|A1Y2C0) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Leishmania tropica PE=3 SV=1
Length = 195
Score = 179 bits (455), Expect = 4e-43, Method: Compositional matrix adjust.
Identities = 90/165 (54%), Positives = 112/165 (67%), Gaps = 2/165 (1%)
Query: 254 LSSDNSYIKFEVKKFSF-LPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC 312
L+S K E + F + K V HEE YL L+ I+ G +K+DRTG GT+S FG
Sbjct: 20 LASSQGRRKSEAEGLEFEICKYVPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGA 79
Query: 313 QMRFNLR-RTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDG 371
QMRF+LR PLLTTK+VFWRGV EELLWF+ G TN +L +K IHIWDGN SR++LD
Sbjct: 80 QMRFSLRGNRLPLLTTKRVFWRGVCEELLWFLRGETNAXLLADKDIHIWDGNGSREFLDS 139
Query: 372 IGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GL + +E DLGPVYGFQWRHFGA Y A+Y G+G DQ+ ++
Sbjct: 140 RGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIRFIV 184
>C8VB77_EMENI (tr|C8VB77) Putative uncharacterized protein OS=Aspergillus
nidulans FGSC A4 GN=ANIA_07028 PE=4 SV=1
Length = 674
Score = 179 bits (454), Expect = 6e-43, Method: Compositional matrix adjust.
Identities = 87/150 (58%), Positives = 103/150 (68%), Gaps = 12/150 (8%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQ-MRFNLRRT-----------FPLLT 326
HEE YL L++ I+++G + DRTGTGT S F MRF+L + PLLT
Sbjct: 362 HEEHQYLNLIRQILAEGEHRPDRTGTGTRSIFAPNPMRFSLSKPSPTNPSTKIPILPLLT 421
Query: 327 TKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVY 386
TK+VF R V+ ELLWFISGST+ L E GI IWDGN SR++LD +GL RE GDLGPVY
Sbjct: 422 TKRVFLRAVLAELLWFISGSTSSIPLSEAGIKIWDGNGSREFLDKVGLSHREVGDLGPVY 481
Query: 387 GFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GFQWRHFGA Y D H DYTGQG DQL D++
Sbjct: 482 GFQWRHFGAEYVDAHTDYTGQGVDQLADIV 511
>B4I2T1_DROSE (tr|B4I2T1) Thymidylate synthase OS=Drosophila sechellia GN=GM18183
PE=3 SV=1
Length = 321
Score = 179 bits (453), Expect = 7e-43, Method: Compositional matrix adjust.
Identities = 81/137 (59%), Positives = 105/137 (76%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEEL 339
+E YL L++ II++G + DRT GTLS FG QMRF++R +FPLLTTK+VF+R V EEL
Sbjct: 35 DEMNYLDLLRHIIANGEQRMDRTEVGTLSVFGSQMRFDMRNSFPLLTTKRVFFRAVAEEL 94
Query: 340 LWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYTD 399
LWF++G T+ K+LQ K +HIWDGN+SR++LD +G R GDLGPVYGFQWRHFGA+Y
Sbjct: 95 LWFVAGKTDAKLLQAKNVHIWDGNSSREFLDKMGFTGRVVGDLGPVYGFQWRHFGAQYGT 154
Query: 400 MHADYTGQGFDQLLDVI 416
+Y+G+G DQL VI
Sbjct: 155 CDDNYSGKGIDQLRQVI 171
>C5DNV0_ZYGRC (tr|C5DNV0) Thymidylate synthase OS=Zygosaccharomyces rouxii
(strain ATCC 2623 / CBS 732 / IFO 1130 / NBRC 1623 /
NCYC 568) GN=ZYRO0A11704g PE=3 SV=1
Length = 310
Score = 179 bits (453), Expect = 8e-43, Method: Compositional matrix adjust.
Identities = 89/139 (64%), Positives = 105/139 (75%), Gaps = 2/139 (1%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL L+Q I+ +G + DRTGTGT S F Q+RF+L FPLLTTKKVF +G++
Sbjct: 19 EEQQYLDLIQRILDEGEFRPDRTGTGTYSIFAPPQLRFDLSNDRFPLLTTKKVFTKGIIL 78
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWFISG T+ K L E+G+ IW+GN SR+YLD IGL DR EGDLGPVYGFQWRHFGA+Y
Sbjct: 79 ELLWFISGCTDGKKLSEQGVKIWEGNGSREYLDKIGLHDRREGDLGPVYGFQWRHFGAKY 138
Query: 398 TDMHADYTGQGFDQLLDVI 416
DYTGQGFDQL +VI
Sbjct: 139 RTCDDDYTGQGFDQLHEVI 157
>A1Y2C1_LEITR (tr|A1Y2C1) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Leishmania tropica PE=3 SV=1
Length = 195
Score = 178 bits (452), Expect = 8e-43, Method: Compositional matrix adjust.
Identities = 89/165 (53%), Positives = 112/165 (67%), Gaps = 2/165 (1%)
Query: 254 LSSDNSYIKFEVKKFSF-LPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC 312
L+S K E + F + K V HEE YL L+ I+ G +K+DRTG GT+ FG
Sbjct: 20 LASSQGRRKSEAEGLEFEICKYVPRNHEERQYLELIDRIMKTGIVKEDRTGVGTIGLFGA 79
Query: 313 QMRFNLR-RTFPLLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDG 371
QMRF+LR PLLTTK+VFWRGV EELLWF+ G TN ++L +K IHIWDGN SR++LD
Sbjct: 80 QMRFSLRGNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDS 139
Query: 372 IGLKDREEGDLGPVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GL + +E DLGPVYGFQWRHFGA Y A+Y G+G DQ+ ++
Sbjct: 140 RGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIRFIV 184
>Q5AXF2_EMENI (tr|Q5AXF2) Putative uncharacterized protein OS=Emericella nidulans
GN=AN7028.2 PE=4 SV=1
Length = 654
Score = 178 bits (452), Expect = 9e-43, Method: Compositional matrix adjust.
Identities = 87/150 (58%), Positives = 103/150 (68%), Gaps = 12/150 (8%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQ-MRFNLRRT-----------FPLLT 326
HEE YL L++ I+++G + DRTGTGT S F MRF+L + PLLT
Sbjct: 342 HEEHQYLNLIRQILAEGEHRPDRTGTGTRSIFAPNPMRFSLSKPSPTNPSTKIPILPLLT 401
Query: 327 TKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVY 386
TK+VF R V+ ELLWFISGST+ L E GI IWDGN SR++LD +GL RE GDLGPVY
Sbjct: 402 TKRVFLRAVLAELLWFISGSTSSIPLSEAGIKIWDGNGSREFLDKVGLSHREVGDLGPVY 461
Query: 387 GFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GFQWRHFGA Y D H DYTGQG DQL D++
Sbjct: 462 GFQWRHFGAEYVDAHTDYTGQGVDQLADIV 491
>Q19N45_PLAVI (tr|Q19N45) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 618
Score = 178 bits (452), Expect = 9e-43, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 318 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 377
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 378 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREANDLG 437
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 438 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 470
Score = 82.0 bits (201), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 72/247 (29%), Positives = 104/247 (42%), Gaps = 50/247 (20%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------KNAVIMGRKTWESIPLEHRPLPGRLNVV 132
+N V+MGR +WESIP +++PLP R+NVV
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVV 129
Query: 133 LTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA 192
L+++ T E+V L K FIIGG Q+ RE L+
Sbjct: 130 LSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLSRNLIKQ 184
Query: 193 IHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDN 252
I+ T I + CD F P+ D S F+ +S V N+ V +V G N
Sbjct: 185 IYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASN 242
Query: 253 GLSSDNS 259
G ++D++
Sbjct: 243 GSTADSA 249
>Q19N44_PLAVI (tr|Q19N44) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 618
Score = 178 bits (452), Expect = 1e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 106/153 (69%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
+++F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 318 HLQEFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 377
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 378 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 437
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 438 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 470
Score = 81.6 bits (200), Expect = 2e-13, Method: Compositional matrix adjust.
Identities = 72/247 (29%), Positives = 103/247 (41%), Gaps = 50/247 (20%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------KNAVIMGRKTWESIPLEHRPLPGRLNVV 132
+N V+MGR WESIP +++PLP R+NVV
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNADKLQNVVVMGRSNWESIPKQYKPLPNRINVV 129
Query: 133 LTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA 192
L+++ T E+V L K FIIGG Q+ RE L+
Sbjct: 130 LSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLSRNLIKQ 184
Query: 193 IHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDN 252
I+ T I + CD F P+ D S F+ +S V N+ V +V G N
Sbjct: 185 IYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASN 242
Query: 253 GLSSDNS 259
G ++D++
Sbjct: 243 GSTADSA 249
>C8ZI35_YEAS8 (tr|C8ZI35) Thymidylate synthase OS=Saccharomyces cerevisiae
(strain Lalvin EC1118 / Prise de mousse)
GN=EC1118_1O4_2784g PE=3 SV=1
Length = 304
Score = 178 bits (451), Expect = 1e-42, Method: Compositional matrix adjust.
Identities = 88/139 (63%), Positives = 105/139 (75%), Gaps = 2/139 (1%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFWRGVVE 337
EE YL L + II +G + DRTGTGTLS F Q+RF+LR TFPLLTTKKVF RG++
Sbjct: 9 EEEQYLDLCKRIIDEGEFRPDRTGTGTLSLFAPPQLRFSLRDDTFPLLTTKKVFTRGIIL 68
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF++G T+ +L E+G+ IWDGN SR+YLD +G KDR+ GDLGPVYGFQWRHFGA+Y
Sbjct: 69 ELLWFLAGDTDANLLSEQGVKIWDGNGSREYLDKMGFKDRKVGDLGPVYGFQWRHFGAKY 128
Query: 398 TDMHADYTGQGFDQLLDVI 416
DYTGQG DQL VI
Sbjct: 129 KTCDDDYTGQGIDQLKQVI 147
>D6W2D7_YEAST (tr|D6W2D7) Cdc21p OS=Saccharomyces cerevisiae S288c GN=CDC21 PE=4
SV=1
Length = 304
Score = 177 bits (450), Expect = 1e-42, Method: Compositional matrix adjust.
Identities = 88/139 (63%), Positives = 105/139 (75%), Gaps = 2/139 (1%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFWRGVVE 337
EE YL L + II +G + DRTGTGTLS F Q+RF+LR TFPLLTTKKVF RG++
Sbjct: 9 EEEQYLDLCKRIIDEGEFRPDRTGTGTLSLFAPPQLRFSLRDDTFPLLTTKKVFTRGIIL 68
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF++G T+ +L E+G+ IWDGN SR+YLD +G KDR+ GDLGPVYGFQWRHFGA+Y
Sbjct: 69 ELLWFLAGDTDANLLSEQGVKIWDGNGSREYLDKMGFKDRKVGDLGPVYGFQWRHFGAKY 128
Query: 398 TDMHADYTGQGFDQLLDVI 416
DYTGQG DQL VI
Sbjct: 129 KTCDDDYTGQGIDQLKQVI 147
>C7GT41_YEAS2 (tr|C7GT41) Thymidylate synthase OS=Saccharomyces cerevisiae
(strain JAY291) GN=CDC21 PE=3 SV=1
Length = 304
Score = 177 bits (450), Expect = 1e-42, Method: Compositional matrix adjust.
Identities = 88/139 (63%), Positives = 105/139 (75%), Gaps = 2/139 (1%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFWRGVVE 337
EE YL L + II +G + DRTGTGTLS F Q+RF+LR TFPLLTTKKVF RG++
Sbjct: 9 EEEQYLDLCKRIIDEGEFRPDRTGTGTLSLFAPPQLRFSLRDDTFPLLTTKKVFTRGIIL 68
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF++G T+ +L E+G+ IWDGN SR+YLD +G KDR+ GDLGPVYGFQWRHFGA+Y
Sbjct: 69 ELLWFLAGDTDANLLSEQGVKIWDGNGSREYLDKMGFKDRKVGDLGPVYGFQWRHFGAKY 128
Query: 398 TDMHADYTGQGFDQLLDVI 416
DYTGQG DQL VI
Sbjct: 129 KTCDDDYTGQGIDQLKQVI 147
>B3LJC3_YEAS1 (tr|B3LJC3) Thymidylate synthase OS=Saccharomyces cerevisiae
(strain RM11-1a) GN=SCRG_01474 PE=3 SV=1
Length = 304
Score = 177 bits (450), Expect = 1e-42, Method: Compositional matrix adjust.
Identities = 88/139 (63%), Positives = 105/139 (75%), Gaps = 2/139 (1%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFWRGVVE 337
EE YL L + II +G + DRTGTGTLS F Q+RF+LR TFPLLTTKKVF RG++
Sbjct: 9 EEEQYLDLCKRIIDEGEFRPDRTGTGTLSLFAPPQLRFSLRDDTFPLLTTKKVFTRGIIL 68
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF++G T+ +L E+G+ IWDGN SR+YLD +G KDR+ GDLGPVYGFQWRHFGA+Y
Sbjct: 69 ELLWFLAGDTDANLLSEQGVKIWDGNGSREYLDKMGFKDRKVGDLGPVYGFQWRHFGAKY 128
Query: 398 TDMHADYTGQGFDQLLDVI 416
DYTGQG DQL VI
Sbjct: 129 KTCDDDYTGQGIDQLKQVI 147
>Q19N42_PLAVI (tr|Q19N42) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 618
Score = 177 bits (450), Expect = 1e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 318 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 377
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 378 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 437
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 438 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 470
Score = 80.1 bits (196), Expect = 4e-13, Method: Compositional matrix adjust.
Identities = 71/247 (28%), Positives = 103/247 (41%), Gaps = 50/247 (20%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------KNAVIMGRKTWESIPLEHRPLPGRLNVV 132
+N V+MGR +WESIP +++PLP R+NVV
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVV 129
Query: 133 LTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA 192
L+++ T E+V L K FIIGG + RE L+
Sbjct: 130 LSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAHVYRECLSRNLIKQ 184
Query: 193 IHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDN 252
I+ T I + CD F P+ D S F+ +S V N+ V +V G N
Sbjct: 185 IYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASN 242
Query: 253 GLSSDNS 259
G ++D++
Sbjct: 243 GSTADSA 249
>Q19N40_PLAVI (tr|Q19N40) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 618
Score = 177 bits (450), Expect = 1e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 318 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 377
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 378 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 437
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 438 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 470
Score = 82.0 bits (201), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 72/247 (29%), Positives = 105/247 (42%), Gaps = 50/247 (20%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------KNAVIMGRKTWESIPLEHRPLPGRLNVV 132
+N V+MGR +WESIP +++PLP R+NVV
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVV 129
Query: 133 LTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA 192
L+++ + + E V I L K FIIGG Q+ RE L+
Sbjct: 130 LSKTLTKE-EVKEKVFIIDSIDDLLLLLKK----LKYYKCFIIGGAQVYRECLSRNLIKQ 184
Query: 193 IHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDN 252
I+ T I + CD F P+ D S F+ +S V N+ V +V G N
Sbjct: 185 IYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASN 242
Query: 253 GLSSDNS 259
G ++D++
Sbjct: 243 GSTADSA 249
>Q19N46_PLAVI (tr|Q19N46) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 618
Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 318 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 377
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 378 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 437
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 438 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 470
Score = 85.5 bits (210), Expect = 1e-14, Method: Compositional matrix adjust.
Identities = 70/247 (28%), Positives = 105/247 (42%), Gaps = 50/247 (20%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------KNAVIMGRKTWESIPLEHRPLPGRLNVV 132
+N V+MGR +WESIP +++PLP R+NVV
Sbjct: 70 EKLKWKRERYLRVEASQGGGDNTSGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVV 129
Query: 133 LTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA 192
L+++ + + + +I Y K FIIGG Q+ RE L+
Sbjct: 130 LSKTLTKEDVKEKVFIIDSIDDLLLLLKKLKCY-----KCFIIGGAQVYRECLSRNLIKQ 184
Query: 193 IHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDN 252
I+ T I + CD F P+ D S F+ +S V N+ V +V G N
Sbjct: 185 IYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASN 242
Query: 253 GLSSDNS 259
G ++D++
Sbjct: 243 GSTADSA 249
>C3RUB1_PLAVI (tr|C3RUB1) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 624
Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 324 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 383
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 384 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 443
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 444 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 476
Score = 79.3 bits (194), Expect = 8e-13, Method: Compositional matrix adjust.
Identities = 72/253 (28%), Positives = 103/253 (40%), Gaps = 56/253 (22%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------------KNAVIMGRKTWESIPLEHRPLP 126
+N V+MGR WESIP +++PLP
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNTHGGDNADKLQNVVVMGRSNWESIPKQYKPLP 129
Query: 127 GRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLN 186
R+NVVL+++ T E+V L K FIIGG Q+ RE L+
Sbjct: 130 NRINVVLSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLS 184
Query: 187 APGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVE 246
I+ T I + CD F P+ D S F+ +S V N+ V +V
Sbjct: 185 RNLIKQIYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGV 242
Query: 247 SHGQDNGLSSDNS 259
G NG ++D++
Sbjct: 243 DGGASNGSTADSA 255
>A5K620_PLAVI (tr|A5K620) Bifunctional dihydrofolate reductase-thymidylate
synthase 1, putative OS=Plasmodium vivax GN=PVX_089950
PE=4 SV=1
Length = 624
Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 324 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 383
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 384 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 443
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 444 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 476
Score = 79.7 bits (195), Expect = 6e-13, Method: Compositional matrix adjust.
Identities = 72/253 (28%), Positives = 104/253 (41%), Gaps = 56/253 (22%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------------KNAVIMGRKTWESIPLEHRPLP 126
+N V+MGR +WESIP +++PLP
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNTHGGDNADKLQNVVVMGRSSWESIPKQYKPLP 129
Query: 127 GRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLN 186
R+NVVL+++ T E+V L K FIIGG Q+ RE L+
Sbjct: 130 NRINVVLSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLS 184
Query: 187 APGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVE 246
I+ T I + CD F P+ D S F+ +S V N+ V +V
Sbjct: 185 RNLIKQIYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGV 242
Query: 247 SHGQDNGLSSDNS 259
G NG ++D++
Sbjct: 243 DGGASNGSTADSA 255
>C4XY75_CLAL4 (tr|C4XY75) Thymidylate synthase OS=Clavispora lusitaniae (strain
ATCC 42720) GN=CLUG_00898 PE=3 SV=1
Length = 317
Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 86/138 (62%), Positives = 101/138 (73%), Gaps = 2/138 (1%)
Query: 281 EFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFWRGVVEE 338
E YL L Q II +G + DRTGTGT S F Q+RF+L TFPLLTTK+VF +G++ E
Sbjct: 9 EQAYLDLCQKIIEEGEFRPDRTGTGTRSLFAPPQLRFDLSNDTFPLLTTKRVFSKGIIHE 68
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWF+ G T+ K L KG+ IW+GN SR+YLD +GL DR EGDLGPVYGFQWRHFGA Y
Sbjct: 69 LLWFVEGCTDAKKLSAKGVRIWEGNGSREYLDKMGLTDRREGDLGPVYGFQWRHFGAEYK 128
Query: 399 DMHADYTGQGFDQLLDVI 416
DY+GQGFDQL DVI
Sbjct: 129 TCDDDYSGQGFDQLQDVI 146
>C3RUA8_PLAVI (tr|C3RUA8) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 624
Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 324 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 383
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 384 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 443
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 444 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 476
Score = 79.7 bits (195), Expect = 7e-13, Method: Compositional matrix adjust.
Identities = 72/253 (28%), Positives = 104/253 (41%), Gaps = 56/253 (22%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------------KNAVIMGRKTWESIPLEHRPLP 126
+N V+MGR +WESIP +++PLP
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNTHGGDNADKLQNVVVMGRSSWESIPKQYKPLP 129
Query: 127 GRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLN 186
R+NVVL+++ T E+V L K FIIGG Q+ RE L+
Sbjct: 130 NRINVVLSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLS 184
Query: 187 APGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVE 246
I+ T I + CD F P+ D S F+ +S V N+ V +V
Sbjct: 185 RNLIKQIYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGV 242
Query: 247 SHGQDNGLSSDNS 259
G NG ++D++
Sbjct: 243 DGGASNGSTADSA 255
>C3RUB2_PLAVI (tr|C3RUB2) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 630
Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 330 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 389
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 390 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 449
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 450 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 482
Score = 77.4 bits (189), Expect = 3e-12, Method: Compositional matrix adjust.
Identities = 72/259 (27%), Positives = 104/259 (40%), Gaps = 62/259 (23%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------------------KNAVIMGRKTWESIPL 120
+N V+MGR +WESIP
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNTHGGDNTHGVDNADKLQNVVVMGRSSWESIPK 129
Query: 121 EHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQI 180
+++PLP R+NVVL+++ T E+V L K FIIGG Q+
Sbjct: 130 QYKPLPNRINVVLSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQV 184
Query: 181 LRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRV 240
RE L+ I+ T I + CD F P+ D S F+ +S V N+ V
Sbjct: 185 YRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYS 242
Query: 241 RVSAVESHGQDNGLSSDNS 259
+V G NG ++D++
Sbjct: 243 KVGGGVDGGASNGSTADSA 261
>Q19PB8_PLAVI (tr|Q19PB8) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 618
Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 80/152 (52%), Positives = 105/152 (69%)
Query: 265 VKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPL 324
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FPL
Sbjct: 319 LQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGAGVMSKFGYMMKFNLSEYFPL 378
Query: 325 LTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGP 384
LTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLGP
Sbjct: 379 LTTKKLFLRGIIEELLWFIRGETNGNTLLNKSVRIWEANGTREFLDNRKLFHREVNDLGP 438
Query: 385 VYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 439 IYGFQWRHFGAEYTNMHDNYEDKGVDQLENVI 470
Score = 82.0 bits (201), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 72/247 (29%), Positives = 104/247 (42%), Gaps = 50/247 (20%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------KNAVIMGRKTWESIPLEHRPLPGRLNVV 132
+N V+MGR +WESIP +++PLP R+NVV
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVV 129
Query: 133 LTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA 192
L+++ T E+V L K FIIGG Q+ RE L+
Sbjct: 130 LSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLSRNLIKQ 184
Query: 193 IHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDN 252
I+ T I + CD F P+ D S F+ +S V N+ V +V G N
Sbjct: 185 IYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASN 242
Query: 253 GLSSDNS 259
G ++D++
Sbjct: 243 GSTADSA 249
>C3RUA7_PLAVI (tr|C3RUA7) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 624
Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 324 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 383
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 384 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 443
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 444 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 476
Score = 79.7 bits (195), Expect = 6e-13, Method: Compositional matrix adjust.
Identities = 72/253 (28%), Positives = 104/253 (41%), Gaps = 56/253 (22%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------------KNAVIMGRKTWESIPLEHRPLP 126
+N V+MGR +WESIP +++PLP
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTHGGDNTHGGDNADKLQNVVVMGRSSWESIPKQYKPLP 129
Query: 127 GRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLN 186
R+NVVL+++ T E+V L K FIIGG Q+ RE L+
Sbjct: 130 NRINVVLSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLS 184
Query: 187 APGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVE 246
I+ T I + CD F P+ D S F+ +S V N+ V +V
Sbjct: 185 RNLIKQIYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGV 242
Query: 247 SHGQDNGLSSDNS 259
G NG ++D++
Sbjct: 243 DGGASNGSTADSA 255
>C3RUA6_PLAVI (tr|C3RUA6) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 624
Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 324 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 383
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 384 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 443
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 444 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 476
Score = 80.1 bits (196), Expect = 5e-13, Method: Compositional matrix adjust.
Identities = 72/253 (28%), Positives = 104/253 (41%), Gaps = 56/253 (22%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F+ VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFRSVTTYVDESKY 69
Query: 105 --------------------------------------KNAVIMGRKTWESIPLEHRPLP 126
+N V+MGR WESIP +++PLP
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNTHGGDNADKLQNVVVMGRSNWESIPKQYKPLP 129
Query: 127 GRLNVVLTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLN 186
R+NVVL+++ T E+V L K FIIGG Q+ RE L+
Sbjct: 130 NRINVVLSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLS 184
Query: 187 APGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVE 246
I+ T I + CD F P+ D S F+ +S V N+ V +V
Sbjct: 185 RNLIKQIYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGV 242
Query: 247 SHGQDNGLSSDNS 259
G NG ++D++
Sbjct: 243 DGGASNGSTADSA 255
>A7ET01_SCLS1 (tr|A7ET01) Thymidylate synthase OS=Sclerotinia sclerotiorum
(strain ATCC 18683 / 1980 / Ss-1) GN=SS1G_08456 PE=3
SV=1
Length = 354
Score = 177 bits (449), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 85/151 (56%), Positives = 104/151 (68%), Gaps = 6/151 (3%)
Query: 272 PKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFG-CQMRFNLRRT-----FPLL 325
P ++HEE+ YL L+++I+ G + DRTGTGT+S F ++F+L PLL
Sbjct: 33 PTSTSKKHEEYQYLDLIREILETGEHRPDRTGTGTISLFAPAPLKFSLTSPTGTPILPLL 92
Query: 326 TTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPV 385
TTK+VF R V+ ELLWFISGST+ L GI IWDGN SR YLD IGL R EGDLGPV
Sbjct: 93 TTKRVFLRAVLTELLWFISGSTSSLPLSAAGIKIWDGNGSRTYLDSIGLSHRAEGDLGPV 152
Query: 386 YGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
YGFQWRHFGA+Y D DYTGQG DQL +++
Sbjct: 153 YGFQWRHFGAKYIDAETDYTGQGVDQLAEIV 183
>C9SFX8_VERA1 (tr|C9SFX8) Thymidylate synthase OS=Verticillium albo-atrum (strain
VaMs.102) GN=VDBG_03491 PE=3 SV=1
Length = 326
Score = 177 bits (449), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 85/144 (59%), Positives = 103/144 (71%), Gaps = 5/144 (3%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFG-CQMRFNLRRT----FPLLTTKKVFW 332
RHEE YL LV++I+ +G + DRTGTGT S F ++F+L + PLLTTK+VF
Sbjct: 16 RHEEHQYLDLVRNILDNGEHRPDRTGTGTYSIFAPTPLKFSLNQNGEPLLPLLTTKRVFL 75
Query: 333 RGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRH 392
R VV ELLWF+ GST+ L E GI IWDGN SR++LD +GL REEGDLGPVYGFQWRH
Sbjct: 76 RAVVAELLWFVQGSTSSIPLSEAGIKIWDGNGSREFLDSVGLSHREEGDLGPVYGFQWRH 135
Query: 393 FGARYTDMHADYTGQGFDQLLDVI 416
FGA Y D DYTGQG DQL +++
Sbjct: 136 FGAEYVDAKTDYTGQGVDQLAEIV 159
>A6RSC0_BOTFB (tr|A6RSC0) Thymidylate synthase OS=Botryotinia fuckeliana (strain
B05.10) GN=BC1G_03147 PE=3 SV=1
Length = 356
Score = 177 bits (448), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 84/146 (57%), Positives = 103/146 (70%), Gaps = 6/146 (4%)
Query: 277 ERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFG-CQMRFNLRRT-----FPLLTTKKV 330
++HEE+ YL L+++I+ G + DRTGTGT+S F ++F+L PLLTTK+V
Sbjct: 36 KKHEEYQYLDLIREILETGEHRPDRTGTGTISLFAPAPLKFSLTSPTGTPILPLLTTKRV 95
Query: 331 FWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQW 390
F R V+ ELLWFISGST+ L GI IWDGN SR YLD IGL R EGDLGPVYGFQW
Sbjct: 96 FLRAVLTELLWFISGSTSSLPLSAAGIKIWDGNGSRAYLDSIGLSHRAEGDLGPVYGFQW 155
Query: 391 RHFGARYTDMHADYTGQGFDQLLDVI 416
RHFGA+Y D DYTGQG DQL +++
Sbjct: 156 RHFGAKYIDAETDYTGQGVDQLAEIV 181
>Q19N43_PLAVI (tr|Q19N43) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 618
Score = 177 bits (448), Expect = 3e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 318 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 377
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 378 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNKKLFHREVNDLG 437
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 438 PIYGFQWRHFGAGYTNMHDNYEDKGVDQLKNVI 470
Score = 82.0 bits (201), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 72/247 (29%), Positives = 104/247 (42%), Gaps = 50/247 (20%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------KNAVIMGRKTWESIPLEHRPLPGRLNVV 132
+N V+MGR +WESIP +++PLP R+NVV
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVV 129
Query: 133 LTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA 192
L+++ T E+V L K FIIGG Q+ RE L+
Sbjct: 130 LSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLSRNLIKQ 184
Query: 193 IHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDN 252
I+ T I + CD F P+ D S F+ +S V N+ V +V G N
Sbjct: 185 IYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASN 242
Query: 253 GLSSDNS 259
G ++D++
Sbjct: 243 GSTADSA 249
>B3L1J6_PLAKH (tr|B3L1J6) Bifunctional dihydrofolate reductase-thymidylate
synthase, putative OS=Plasmodium knowlesi (strain H)
GN=PKH_052130 PE=4 SV=1
Length = 626
Score = 176 bits (446), Expect = 4e-42, Method: Compositional matrix adjust.
Identities = 79/153 (51%), Positives = 106/153 (69%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 326 HLQDFKIYNSVKIKQHPEYQYLSIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLNEYFP 385
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L +K + IW+ N +R++LD L RE DLG
Sbjct: 386 LLTTKKLFLRGIIEELLWFIRGETNGNTLLKKNVRIWEANGTREFLDNRKLFHREVNDLG 445
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+M+ +Y +G DQL +VI
Sbjct: 446 PIYGFQWRHFGAEYTNMYDNYEDKGVDQLKNVI 478
Score = 78.6 bits (192), Expect = 1e-12, Method: Compositional matrix adjust.
Identities = 62/223 (27%), Positives = 91/223 (40%), Gaps = 46/223 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVT------------------------------------ 96
G+G G LPW+ S D+K+F VT
Sbjct: 38 GLGNNGALPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLQREASVGNVETHCGGDT 97
Query: 97 LTTSDSGRK--NAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXX 154
+ T D+ K N V+MGR +WESIP +++PLP R+NVVL+++ + + + +I
Sbjct: 98 VETEDNTTKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTHEQVKEKVFIIQSIDD 157
Query: 155 XXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSS 214
L K FIIGG Q+ +E LN I+ T I + CD P+ D
Sbjct: 158 LLLLLKK-----LKYYKCFIIGGAQVYKECLNRNLIKQIYFTRINNAYQCDVLFPQFDEG 212
Query: 215 VFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSD 257
F+ +S V NN + +V G NG + D
Sbjct: 213 QFR--MTSVSEVYNNKGTTLDFVIYSKVGGEVDGGASNGSTMD 253
>Q8JKK4_9VIRU (tr|Q8JKK4) Thymidylate synthase OS=Heliothis zea virus 1 GN=orf109
PE=3 SV=1
Length = 291
Score = 176 bits (446), Expect = 5e-42, Method: Compositional matrix adjust.
Identities = 83/138 (60%), Positives = 98/138 (71%), Gaps = 1/138 (0%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLR-RTFPLLTTKKVFWRGVVEE 338
EE YL ++ II GN + DRT GTLS FG R++LR + PLLTTK VF +GV+EE
Sbjct: 6 EEHQYLNTIRSIIETGNRRMDRTKVGTLSHFGVMHRYSLRDNSLPLLTTKTVFVKGVIEE 65
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLW ISGSTN K L KG+HIW GN+SR LD +G DR+EGDLGPVYGFQWRH G +Y
Sbjct: 66 LLWMISGSTNAKELSRKGVHIWSGNSSRSVLDSLGFTDRQEGDLGPVYGFQWRHSGTKYV 125
Query: 399 DMHADYTGQGFDQLLDVI 416
D DY+GQG DQL +I
Sbjct: 126 DCETDYSGQGVDQLQTII 143
>Q19PC0_PLAVI (tr|Q19PC0) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 618
Score = 176 bits (445), Expect = 6e-42, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 104/153 (67%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG M+FNL FP
Sbjct: 318 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFP 377
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG +EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 378 LLTTKKLFLRGKIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 437
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 438 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 470
Score = 82.0 bits (201), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 72/247 (29%), Positives = 104/247 (42%), Gaps = 50/247 (20%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------KNAVIMGRKTWESIPLEHRPLPGRLNVV 132
+N V+MGR +WESIP +++PLP R+NVV
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVV 129
Query: 133 LTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA 192
L+++ T E+V L K FIIGG Q+ RE L+
Sbjct: 130 LSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLSRNLIKQ 184
Query: 193 IHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDN 252
I+ T I + CD F P+ D S F+ +S V N+ V +V G N
Sbjct: 185 IYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASN 242
Query: 253 GLSSDNS 259
G ++D++
Sbjct: 243 GSTADSA 249
>Q53D48_9GAMA (tr|Q53D48) Thymidylate synthase OS=Macaca fuscata rhadinovirus
GN=JM22 PE=3 SV=1
Length = 333
Score = 175 bits (444), Expect = 7e-42, Method: Compositional matrix adjust.
Identities = 85/138 (61%), Positives = 95/138 (68%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEE 338
H E YL + II G +DDRTG GT S FG Q R+NLR FPLLTTK+VFWRGVVEE
Sbjct: 48 HGELQYLAHLDLIIRHGVQRDDRTGVGTRSVFGLQARYNLRDEFPLLTTKRVFWRGVVEE 107
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWFI GST+ L +G+ IWD + SR +L G DR EGDLGPVYGFQWRHFGA Y
Sbjct: 108 LLWFIRGSTDSTELSRRGVKIWDAHGSRAFLAAQGFGDRREGDLGPVYGFQWRHFGAEYR 167
Query: 399 DMHADYTGQGFDQLLDVI 416
ADY GQG DQL V+
Sbjct: 168 GADADYEGQGVDQLRYVV 185
>C0NVN1_AJECG (tr|C0NVN1) Thymidylate synthase OS=Ajellomyces capsulata (strain
ATCC 26029 / G186AR / H82 / RMSCC 2432) GN=HCBG_07211
PE=3 SV=1
Length = 369
Score = 175 bits (444), Expect = 7e-42, Method: Compositional matrix adjust.
Identities = 85/153 (55%), Positives = 101/153 (66%), Gaps = 15/153 (9%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR--------------TFP 323
HEE YLRL++ I+ G + DRTGTGT S F Q+RF+L + P
Sbjct: 44 HEEHQYLRLIRSILETGEHRPDRTGTGTRSLFAPPQLRFSLSKRTTSNPTSTSSRTPVLP 103
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTK+VF R V+ ELLWFISGST+ L E G+ IWDGN SR+YLD +GL R GDLG
Sbjct: 104 LLTTKRVFLRAVIAELLWFISGSTSSLPLSEAGVKIWDGNGSREYLDSVGLSHRAVGDLG 163
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
PVYGFQWRHFGA Y D DYTGQG DQ+ +V+
Sbjct: 164 PVYGFQWRHFGAEYIDAQTDYTGQGVDQIAEVV 196
>C3S7P8_PLAFA (tr|C3S7P8) Dihydrofolate reductase/thymidylate synthase
OS=Plasmodium falciparum GN=dhfr-ts PE=4 SV=1
Length = 608
Score = 175 bits (444), Expect = 9e-42, Method: Compositional matrix adjust.
Identities = 77/149 (51%), Positives = 104/149 (69%)
Query: 268 FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTT 327
F + ++ H E+ YL ++ DI+ +GN + DRTG G LSKFG M+F+L + FPLLTT
Sbjct: 312 FQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTT 371
Query: 328 KKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYG 387
KK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLGP+YG
Sbjct: 372 KKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYG 431
Query: 388 FQWRHFGARYTDMHADYTGQGFDQLLDVI 416
FQWRHFGA YT+M+ +Y +G DQL ++I
Sbjct: 432 FQWRHFGAEYTNMYDNYENKGVDQLKNII 460
Score = 80.9 bits (198), Expect = 2e-13, Method: Compositional matrix adjust.
Identities = 60/217 (27%), Positives = 91/217 (41%), Gaps = 40/217 (18%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR---------------------------- 104
G+G +G LPW+ S D+K+F+ VT ++S
Sbjct: 39 GLGNKGVLPWKCNSLDMKYFRAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 98
Query: 105 KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS---GSFDIATAENVVICGXXXXXXXXXX 161
+N V+MGR WESIP + +PL R+NV+L+R+ FD E+V I
Sbjct: 99 QNVVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 154
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYS 221
L+ K FIIGG + +E L I+ T I ++ +CD F P+I+ + +Q
Sbjct: 155 K----LNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISV 210
Query: 222 SFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDN 258
S NN F Y + + G +N
Sbjct: 211 SDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNN 247
>Q8I1R6_PLAF7 (tr|Q8I1R6) Bifunctional dihydrofolate reductase-thymidylate
synthase OS=Plasmodium falciparum (isolate 3D7)
GN=DHFR-TS PE=1 SV=1
Length = 608
Score = 175 bits (444), Expect = 9e-42, Method: Compositional matrix adjust.
Identities = 77/149 (51%), Positives = 104/149 (69%)
Query: 268 FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTT 327
F + ++ H E+ YL ++ DI+ +GN + DRTG G LSKFG M+F+L + FPLLTT
Sbjct: 312 FQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTT 371
Query: 328 KKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYG 387
KK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLGP+YG
Sbjct: 372 KKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYG 431
Query: 388 FQWRHFGARYTDMHADYTGQGFDQLLDVI 416
FQWRHFGA YT+M+ +Y +G DQL ++I
Sbjct: 432 FQWRHFGAEYTNMYDNYENKGVDQLKNII 460
Score = 79.3 bits (194), Expect = 7e-13, Method: Compositional matrix adjust.
Identities = 60/217 (27%), Positives = 91/217 (41%), Gaps = 40/217 (18%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR---------------------------- 104
G+G +G LPW+ S D+K+F VT ++S
Sbjct: 39 GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 98
Query: 105 KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS---GSFDIATAENVVICGXXXXXXXXXX 161
+N V+MGR +WESIP + +PL R+NV+L+R+ FD E+V I
Sbjct: 99 QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 154
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYS 221
L+ K FIIGG + +E L I+ T I ++ +CD F P+I+ + +Q
Sbjct: 155 K----LNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISV 210
Query: 222 SFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDN 258
S NN F Y + + G +N
Sbjct: 211 SDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNN 247
>A7UD81_PLAFA (tr|A7UD81) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium falciparum GN=DHFR-TS PE=4 SV=1
Length = 608
Score = 175 bits (444), Expect = 9e-42, Method: Compositional matrix adjust.
Identities = 77/149 (51%), Positives = 104/149 (69%)
Query: 268 FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTT 327
F + ++ H E+ YL ++ DI+ +GN + DRTG G LSKFG M+F+L + FPLLTT
Sbjct: 312 FQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTT 371
Query: 328 KKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYG 387
KK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLGP+YG
Sbjct: 372 KKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYG 431
Query: 388 FQWRHFGARYTDMHADYTGQGFDQLLDVI 416
FQWRHFGA YT+M+ +Y +G DQL ++I
Sbjct: 432 FQWRHFGAEYTNMYDNYENKGVDQLKNII 460
Score = 79.3 bits (194), Expect = 7e-13, Method: Compositional matrix adjust.
Identities = 60/217 (27%), Positives = 91/217 (41%), Gaps = 40/217 (18%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR---------------------------- 104
G+G +G LPW+ S D+K+F VT ++S
Sbjct: 39 GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 98
Query: 105 KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS---GSFDIATAENVVICGXXXXXXXXXX 161
+N V+MGR +WESIP + +PL R+NV+L+R+ FD E+V I
Sbjct: 99 QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 154
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYS 221
L+ K FIIGG + +E L I+ T I ++ +CD F P+I+ + +Q
Sbjct: 155 K----LNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISV 210
Query: 222 SFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDN 258
S NN F Y + + G +N
Sbjct: 211 SDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNN 247
>A7UD79_PLAFA (tr|A7UD79) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium falciparum GN=DHFR-TS PE=4 SV=1
Length = 608
Score = 175 bits (444), Expect = 9e-42, Method: Compositional matrix adjust.
Identities = 77/149 (51%), Positives = 104/149 (69%)
Query: 268 FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTT 327
F + ++ H E+ YL ++ DI+ +GN + DRTG G LSKFG M+F+L + FPLLTT
Sbjct: 312 FQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTT 371
Query: 328 KKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYG 387
KK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLGP+YG
Sbjct: 372 KKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYG 431
Query: 388 FQWRHFGARYTDMHADYTGQGFDQLLDVI 416
FQWRHFGA YT+M+ +Y +G DQL ++I
Sbjct: 432 FQWRHFGAEYTNMYDNYENKGVDQLKNII 460
Score = 80.1 bits (196), Expect = 5e-13, Method: Compositional matrix adjust.
Identities = 60/217 (27%), Positives = 91/217 (41%), Gaps = 40/217 (18%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR---------------------------- 104
G+G +G LPW+ S D+K+F VT ++S
Sbjct: 39 GLGNKGVLPWKCNSLDMKYFYAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 98
Query: 105 KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS---GSFDIATAENVVICGXXXXXXXXXX 161
+N V+MGR +WESIP + +PL R+NV+L+R+ FD E+V I
Sbjct: 99 QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 154
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYS 221
L+ K FIIGG + +E L I+ T I ++ +CD F P+I+ + +Q
Sbjct: 155 K----LNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISV 210
Query: 222 SFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDN 258
S NN F Y + + G +N
Sbjct: 211 SDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNN 247
>B5VRX1_YEAS6 (tr|B5VRX1) YOR074Cp-like protein (Fragment) OS=Saccharomyces
cerevisiae (strain AWRI1631) GN=AWRI1631_152350 PE=3
SV=1
Length = 164
Score = 175 bits (444), Expect = 9e-42, Method: Compositional matrix adjust.
Identities = 89/145 (61%), Positives = 107/145 (73%), Gaps = 2/145 (1%)
Query: 274 MVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVF 331
M + EE YL L + II +G + DRTGTGTLS F Q+RF+LR TFPLLTTKKVF
Sbjct: 3 MDGKNKEEEQYLDLCKRIIDEGEFRPDRTGTGTLSLFAPPQLRFSLRDDTFPLLTTKKVF 62
Query: 332 WRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWR 391
RG++ ELLWF++G T+ +L E+G+ IWDGN SR+YLD +G KDR+ GDLGPVYGFQWR
Sbjct: 63 TRGIILELLWFLAGDTDANLLSEQGVKIWDGNGSREYLDKMGFKDRKVGDLGPVYGFQWR 122
Query: 392 HFGARYTDMHADYTGQGFDQLLDVI 416
HFGA+Y DYTGQG DQL VI
Sbjct: 123 HFGAKYKTCDDDYTGQGIDQLKQVI 147
>A6RED4_AJECN (tr|A6RED4) Thymidylate synthase OS=Ajellomyces capsulata (strain
NAm1 / WU24) GN=HCAG_07999 PE=3 SV=1
Length = 315
Score = 175 bits (443), Expect = 1e-41, Method: Compositional matrix adjust.
Identities = 85/153 (55%), Positives = 101/153 (66%), Gaps = 15/153 (9%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR--------------TFP 323
HEE YLRL++ I+ G + DRTGTGT S F Q+RF+L + P
Sbjct: 44 HEEHQYLRLIRSILETGEHRPDRTGTGTCSLFAPPQLRFSLSKRTTSNPTSTSSRTPVLP 103
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTK+VF R V+ ELLWFISGST+ L E G+ IWDGN SR+YLD +GL R GDLG
Sbjct: 104 LLTTKRVFLRAVIAELLWFISGSTSSLPLSEAGVKIWDGNGSREYLDSVGLSHRAVGDLG 163
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
PVYGFQWRHFGA Y D DYTGQG DQ+ +V+
Sbjct: 164 PVYGFQWRHFGAEYIDAQTDYTGQGVDQIAEVV 196
>D3VZV8_PLARE (tr|D3VZV8) Dihydrofolate reductase-thymidylate synthase (Fragment)
OS=Plasmodium reichenowi GN=DHFR-TS PE=4 SV=1
Length = 598
Score = 175 bits (443), Expect = 1e-41, Method: Compositional matrix adjust.
Identities = 77/149 (51%), Positives = 104/149 (69%)
Query: 268 FSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTT 327
F + ++ H E+ YL ++ DI+ +GN + DRTG G LSKFG M+F+L + FPLLTT
Sbjct: 303 FQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTT 362
Query: 328 KKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYG 387
KK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLGP+YG
Sbjct: 363 KKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYG 422
Query: 388 FQWRHFGARYTDMHADYTGQGFDQLLDVI 416
FQWRHFGA YT+M+ +Y +G DQL ++I
Sbjct: 423 FQWRHFGAEYTNMYDNYENKGVDQLKNII 451
Score = 78.2 bits (191), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 58/198 (29%), Positives = 86/198 (43%), Gaps = 40/198 (20%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR---------------------------- 104
G+G +G LPW+ S D+K+F VT ++S
Sbjct: 31 GLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKL 90
Query: 105 KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRS---GSFDIATAENVVICGXXXXXXXXXX 161
+N V+MGR +WESIP + +PL R+NV+L+R+ FD E+V I
Sbjct: 91 QNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFD----EDVYIINKVEDLIVLLG 146
Query: 162 XXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWYS 221
L+ K FIIGG + +E L I+ T I ++ +CD F P I+ + +Q
Sbjct: 147 K----LNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPAINENEYQIISV 202
Query: 222 SFPIVENNVRYCFATYVR 239
S NN F Y +
Sbjct: 203 SDVYTSNNTTLDFIIYQK 220
>A8NHY0_COPC7 (tr|A8NHY0) Thymidylate synthase OS=Coprinopsis cinerea (strain
Okayama-7 / 130 / FGSC 9003) GN=CC1G_01532 PE=3 SV=1
Length = 319
Score = 175 bits (443), Expect = 1e-41, Method: Compositional matrix adjust.
Identities = 82/140 (58%), Positives = 104/140 (74%), Gaps = 2/140 (1%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNL-RRTFPLLTTKKVFWRGVV 336
HEE+ YL L++ ++ G+++ DRTGTGT++ F RF+L T PLLTTK+ F RG++
Sbjct: 22 HEEYQYLSLIRRVLDTGDIRPDRTGTGTIALFAPPSFRFSLLDATLPLLTTKRTFLRGII 81
Query: 337 EELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGAR 396
EELLWF+ G T+ K+L EKGI IWDGN S+++L+ GL R EGDLGPVYGFQWRHFGA
Sbjct: 82 EELLWFVHGCTDSKLLSEKGIKIWDGNGSKEFLESRGLGHRREGDLGPVYGFQWRHFGAE 141
Query: 397 YTDMHADYTGQGFDQLLDVI 416
Y D ADYTGQG DQL + I
Sbjct: 142 YVDCDADYTGQGVDQLRECI 161
>Q2GPK8_CHAGB (tr|Q2GPK8) Thymidylate synthase OS=Chaetomium globosum
GN=CHGG_10096 PE=3 SV=1
Length = 348
Score = 174 bits (442), Expect = 1e-41, Method: Compositional matrix adjust.
Identities = 82/144 (56%), Positives = 105/144 (72%), Gaps = 5/144 (3%)
Query: 278 RHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQ-MRFNLRR----TFPLLTTKKVFW 332
RHEE+ YL LV++I+ +G L+ DRTGTGT S F + ++F+L R PLLTTK+VF
Sbjct: 20 RHEEYQYLDLVREILDEGELRSDRTGTGTYSIFAPRPLKFSLNRDGVPILPLLTTKRVFT 79
Query: 333 RGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRH 392
+ V+ ELLWFISG T+ L +G+ IWDGN SR++LD +GL R EGDLGPVYGFQWRH
Sbjct: 80 KAVIAELLWFISGDTSSHTLSSQGVKIWDGNGSREFLDKLGLTSRAEGDLGPVYGFQWRH 139
Query: 393 FGARYTDMHADYTGQGFDQLLDVI 416
FGA+Y D DYTG+G DQL ++
Sbjct: 140 FGAQYVDSATDYTGKGVDQLARIV 163
>Q19N41_PLAVI (tr|Q19N41) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 618
Score = 174 bits (442), Expect = 1e-41, Method: Compositional matrix adjust.
Identities = 79/153 (51%), Positives = 104/153 (67%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SK G M+FNL FP
Sbjct: 318 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKCGYMMKFNLSEYFP 377
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G TN L K + IW+ N +R++LD L RE DLG
Sbjct: 378 LLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 437
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 438 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 470
Score = 80.5 bits (197), Expect = 4e-13, Method: Compositional matrix adjust.
Identities = 64/219 (29%), Positives = 94/219 (42%), Gaps = 40/219 (18%)
Query: 74 GIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR---------------------------- 104
G+G +G LPW+ S D+K+F VT +S
Sbjct: 38 GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDN 97
Query: 105 ----KNAVIMGRKTWESIPLEHRPLPGRLNVVLTRSGSFDIATAENVVICGXXXXXXXXX 160
+N V+MGR +WESIP +++PLP R+NVVL+++ T E+V
Sbjct: 98 ADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKT-----LTKEDVKEKVFIIDRIDDL 152
Query: 161 XXXPYCLSIEKVFIIGGGQILRESLNAPGCDAIHITEIETSIDCDTFIPKIDSSVFQPWY 220
L K FIIGG Q+ RE L+ I+ T I + CD F P+ D S F+
Sbjct: 153 LLLLKKLKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFR--V 210
Query: 221 SSFPIVENNVRYCFATYVRVRVSAVESHGQDNGLSSDNS 259
+S V N+ V +V G NG ++D++
Sbjct: 211 TSVSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTADSA 249
>A8Q268_MALGO (tr|A8Q268) Thymidylate synthase OS=Malassezia globosa (strain ATCC
96807 / CBS 7966) GN=MGL_2153 PE=3 SV=1
Length = 535
Score = 174 bits (441), Expect = 2e-41, Method: Compositional matrix adjust.
Identities = 83/141 (58%), Positives = 103/141 (73%), Gaps = 3/141 (2%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQ--MRFNLRR-TFPLLTTKKVFWRGV 335
HEE+ YL LV II G ++ DRTGTGT+++F ++F+L PLLTTK+VF+RGV
Sbjct: 236 HEEYQYLNLVSSIIRHGEIRADRTGTGTIAQFAPTRTLKFDLSGGKLPLLTTKRVFFRGV 295
Query: 336 VEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGA 395
+EELLWFI+G T+ K L E+ +HIWDGN S ++L GL R EGDLGP+YGFQWRHFGA
Sbjct: 296 LEELLWFIAGCTDAKRLSERDVHIWDGNGSLEFLQRRGLSHRREGDLGPIYGFQWRHFGA 355
Query: 396 RYTDMHADYTGQGFDQLLDVI 416
+Y D DYTGQG DQL VI
Sbjct: 356 KYIDADTDYTGQGVDQLAQVI 376
>A2R2F6_ASPNC (tr|A2R2F6) Thymidylate synthase OS=Aspergillus niger (strain CBS
513.88 / FGSC A1513) GN=An14g00570 PE=3 SV=1
Length = 356
Score = 174 bits (441), Expect = 2e-41, Method: Compositional matrix adjust.
Identities = 87/153 (56%), Positives = 103/153 (67%), Gaps = 15/153 (9%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRRT--------------FP 323
HEE YL L++ I+S+G + DRTGTGT S F QMRF+L + P
Sbjct: 35 HEEHQYLNLIRRILSEGEHRPDRTGTGTRSIFAPPQMRFSLSKPSTNTTTGIKEYTPILP 94
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTK+VF R V+ ELLWFISG+T+ L E GI IWDGN SR+YLD +GL RE GDLG
Sbjct: 95 LLTTKRVFLRAVLAELLWFISGTTSSLPLSEAGIKIWDGNGSREYLDKVGLSHREVGDLG 154
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
PVYGFQWRHFGA Y D DY+GQG DQL +V+
Sbjct: 155 PVYGFQWRHFGAEYVDAKTDYSGQGVDQLAEVV 187
>C5DJN5_LACTC (tr|C5DJN5) Thymidylate synthase OS=Lachancea thermotolerans
(strain CBS 6340) GN=KLTH0F17864g PE=3 SV=1
Length = 328
Score = 174 bits (441), Expect = 2e-41, Method: Compositional matrix adjust.
Identities = 87/139 (62%), Positives = 103/139 (74%), Gaps = 2/139 (1%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKF-GCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
EE YL L Q II +G+ + DRTGTGT S F Q+RF+L FPLLTTK+VF +G++
Sbjct: 35 EEQQYLDLCQRIIEEGDFRPDRTGTGTYSLFVPPQLRFDLSNDRFPLLTTKRVFTKGIIL 94
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWFISG T+ K L E+G+ IW+GN SR+YLD +GL DR EGDLGPVYGFQWRHFGA Y
Sbjct: 95 ELLWFISGCTDGKKLSEQGVKIWEGNGSREYLDKLGLTDRREGDLGPVYGFQWRHFGADY 154
Query: 398 TDMHADYTGQGFDQLLDVI 416
DYT QGFDQL D+I
Sbjct: 155 KTCEDDYTNQGFDQLEDII 173
>Q19PB9_PLAVI (tr|Q19PB9) Dihydrofolate reductase-thymidylate synthase
OS=Plasmodium vivax GN=DHFR-TS PE=4 SV=1
Length = 618
Score = 174 bits (440), Expect = 2e-41, Method: Compositional matrix adjust.
Identities = 78/153 (50%), Positives = 105/153 (68%)
Query: 264 EVKKFSFLPKMVFERHEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFP 323
++ F + ++H E+ YL ++ DII +GN + DRTG G +SKFG ++FNL FP
Sbjct: 318 HLQDFKIYNSLKIKQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMVKFNLSEYFP 377
Query: 324 LLTTKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLG 383
LLTTKK+F RG++EELLWFI G T+ L K + IW+ N +R++LD L RE DLG
Sbjct: 378 LLTTKKLFLRGIIEELLWFIRGETDGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLG 437
Query: 384 PVYGFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
P+YGFQWRHFGA YT+MH +Y +G DQL +VI
Sbjct: 438 PIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVI 470
Score = 82.4 bits (202), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 72/247 (29%), Positives = 104/247 (42%), Gaps = 50/247 (20%)
Query: 46 ASLSNGTANIQSDPRRTYQVVVAATRDMGIGKEGKLPWRLPS-DLKFFKDVTLTTSDSGR 104
A S GT N PR T++ G+G +G LPW+ S D+K+F VT +S
Sbjct: 20 APTSEGTKNEPFSPR-TFR---------GLGNKGTLPWKCNSVDMKYFSSVTTYVDESKY 69
Query: 105 --------------------------------KNAVIMGRKTWESIPLEHRPLPGRLNVV 132
+N V+MGR +WESIP +++PLP R+NVV
Sbjct: 70 EKLKWKRERYLRMEASQGGGDNTSGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVV 129
Query: 133 LTRSGSFDIATAENVVICGXXXXXXXXXXXXPYCLSIEKVFIIGGGQILRESLNAPGCDA 192
L+++ T E+V L K FIIGG Q+ RE L+
Sbjct: 130 LSKT-----LTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVFRECLSRNLIKQ 184
Query: 193 IHITEIETSIDCDTFIPKIDSSVFQPWYSSFPIVENNVRYCFATYVRVRVSAVESHGQDN 252
I+ T I + CD F P+ D S F+ +S V N+ V +V G N
Sbjct: 185 IYFTRINGAYPCDVFFPEFDESQFR--VTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASN 242
Query: 253 GLSSDNS 259
G ++D++
Sbjct: 243 GSTADSA 249
>Q6CXJ0_KLULA (tr|Q6CXJ0) Thymidylate synthase OS=Kluyveromyces lactis
GN=KLLA0A07843g PE=3 SV=1
Length = 312
Score = 174 bits (440), Expect = 2e-41, Method: Compositional matrix adjust.
Identities = 84/139 (60%), Positives = 104/139 (74%), Gaps = 2/139 (1%)
Query: 280 EEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-TFPLLTTKKVFWRGVVE 337
EE YL L + II++G + DRTGTGT S F Q+RFNL TFPLLTTK+VF +G++
Sbjct: 19 EEQQYLDLCERIINEGEFRPDRTGTGTYSLFAPPQLRFNLSNDTFPLLTTKRVFTKGIIL 78
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELLWF++G T+ K L E+G+ IW+GN SR+YLD +GL DR EGDLGPVYGFQWRHFGA Y
Sbjct: 79 ELLWFVAGCTDGKKLSEQGVKIWEGNGSREYLDSLGLTDRREGDLGPVYGFQWRHFGAEY 138
Query: 398 TDMHADYTGQGFDQLLDVI 416
DY+GQG DQL ++I
Sbjct: 139 KTCDDDYSGQGVDQLKEII 157
>A1D9J9_NEOFI (tr|A1D9J9) Thymidylate synthase OS=Neosartorya fischeri (strain
ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181)
GN=NFIA_029120 PE=3 SV=1
Length = 344
Score = 174 bits (440), Expect = 3e-41, Method: Compositional matrix adjust.
Identities = 86/150 (57%), Positives = 102/150 (68%), Gaps = 12/150 (8%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRR-----------TFPLLT 326
HEE YL L++ I+S+G + DRTGTGT S F Q+RF+L + PLLT
Sbjct: 37 HEEHQYLNLIRTILSEGEHRPDRTGTGTRSIFAPPQLRFSLSKPGATPSSDPIPVLPLLT 96
Query: 327 TKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVY 386
TK+VF R V+ ELLWFISG T+ L E GI IWDGN SR++LD +GL RE GDLGPVY
Sbjct: 97 TKRVFLRAVIAELLWFISGCTSSIPLSEAGIKIWDGNGSREFLDKVGLGHREVGDLGPVY 156
Query: 387 GFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GFQWRHFGA Y D DYTGQG DQL +V+
Sbjct: 157 GFQWRHFGAEYIDAKTDYTGQGVDQLAEVV 186
>B6H3G1_PENCW (tr|B6H3G1) Thymidylate synthase OS=Penicillium chrysogenum (strain
ATCC 28089 / DSM 1075 / Wisconsin 54-1255) GN=Pc13g06460
PE=3 SV=1
Length = 336
Score = 173 bits (439), Expect = 3e-41, Method: Compositional matrix adjust.
Identities = 87/149 (58%), Positives = 102/149 (68%), Gaps = 11/149 (7%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRRT----------FPLLTT 327
HEE YL L++ I+S+G + DRTGTGT S F Q+RF+L + PLLTT
Sbjct: 21 HEEHQYLNLIRTILSEGEHRPDRTGTGTQSIFAPPQLRFSLSKPNPEGGEPIPILPLLTT 80
Query: 328 KKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYG 387
K+VF R V+ ELLWFISG T+ L E GI IWDGN SR++LD GL REEGDLGPVYG
Sbjct: 81 KRVFLRAVLAELLWFISGCTSSLPLSEAGIKIWDGNGSREFLDKSGLGHREEGDLGPVYG 140
Query: 388 FQWRHFGARYTDMHADYTGQGFDQLLDVI 416
FQWRHFGA Y D DY+GQG DQL DV+
Sbjct: 141 FQWRHFGAEYVDAKTDYSGQGVDQLKDVV 169
>B7XJG9_ENTBH (tr|B7XJG9) Thymidylate synthase OS=Enterocytozoon bieneusi (strain
H348) GN=EBI_22497 PE=3 SV=1
Length = 291
Score = 173 bits (438), Expect = 4e-41, Method: Compositional matrix adjust.
Identities = 83/139 (59%), Positives = 106/139 (76%), Gaps = 2/139 (1%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRT-FPLLTTKKVFWRGVVE 337
HEE YL L++ I+ DG +DRTGTGT S FG Q+RF+LR FPLLTTK+V + ++
Sbjct: 5 HEEHQYLELIKRILRDGIQCNDRTGTGTRSVFGAQLRFSLRNNQFPLLTTKRVAIKSIIG 64
Query: 338 ELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARY 397
ELL+FI G TN K+L+++GIHIWDGN++R++ D +G++ REE DLGPVYGFQWRHFGA Y
Sbjct: 65 ELLFFIRGQTNNKILKQQGIHIWDGNSTREFFDKVGIQ-REEDDLGPVYGFQWRHFGAHY 123
Query: 398 TDMHADYTGQGFDQLLDVI 416
H DYTG+G DQL VI
Sbjct: 124 KTCHDDYTGEGVDQLKYVI 142
>C4JH67_UNCRE (tr|C4JH67) Thymidylate synthase OS=Uncinocarpus reesii (strain
UAMH 1704) GN=UREG_02640 PE=3 SV=1
Length = 347
Score = 172 bits (437), Expect = 5e-41, Method: Compositional matrix adjust.
Identities = 82/150 (54%), Positives = 104/150 (69%), Gaps = 12/150 (8%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRRT-----------FPLLT 326
HEE YL L++ I++ G + DRTGTGT S F Q+RF+L + PLLT
Sbjct: 34 HEEHQYLNLIRSILTTGEHRPDRTGTGTRSLFAPPQLRFSLSKPGPASSSAPIPILPLLT 93
Query: 327 TKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVY 386
TK+VF R V+ ELLWF+SGST+ L E G+ IWDGN SR++LD +GL R+ GDLGPVY
Sbjct: 94 TKRVFLRAVILELLWFVSGSTSSIPLSEAGVKIWDGNGSREFLDSVGLSHRDVGDLGPVY 153
Query: 387 GFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GFQWRHFGA Y D ADYTG+G DQ+++V+
Sbjct: 154 GFQWRHFGAEYVDAKADYTGKGVDQIVEVV 183
>Q9J2M3_9GAMA (tr|Q9J2M3) Thymidylate synthase OS=Rhesus monkey rhadinovirus
H26-95 GN=ORF70 PE=3 SV=1
Length = 333
Score = 172 bits (437), Expect = 5e-41, Method: Compositional matrix adjust.
Identities = 83/138 (60%), Positives = 95/138 (68%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGCQMRFNLRRTFPLLTTKKVFWRGVVEE 338
H E YL + II G ++DRTG GT S FG Q R+NLR FPLLTTK+VFWRGVVEE
Sbjct: 48 HGELQYLAHLDLIIKHGVQREDRTGVGTRSVFGLQARYNLRDEFPLLTTKRVFWRGVVEE 107
Query: 339 LLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVYGFQWRHFGARYT 398
LLWFI GST+ L +G+ IWD + SR +L G DR EGDLGPVYGFQWRHFGA Y
Sbjct: 108 LLWFIRGSTDSTELSRRGVKIWDAHGSRAFLAAQGFGDRREGDLGPVYGFQWRHFGAEYR 167
Query: 399 DMHADYTGQGFDQLLDVI 416
A+Y GQG DQL V+
Sbjct: 168 GADANYEGQGVDQLRYVV 185
>Q4W9N9_ASPFU (tr|Q4W9N9) Thymidylate synthase OS=Aspergillus fumigatus
GN=AFUA_4G04270 PE=3 SV=1
Length = 344
Score = 172 bits (437), Expect = 5e-41, Method: Compositional matrix adjust.
Identities = 85/150 (56%), Positives = 102/150 (68%), Gaps = 12/150 (8%)
Query: 279 HEEFLYLRLVQDIISDGNLKDDRTGTGTLSKFGC-QMRFNLRRT-----------FPLLT 326
HEE YL L++ I+++G + DRTGTGT S F Q+RF+L + PLLT
Sbjct: 37 HEEHQYLNLIRTILAEGEHRPDRTGTGTRSIFAPPQLRFSLSKPGATPSSDPIPILPLLT 96
Query: 327 TKKVFWRGVVEELLWFISGSTNCKVLQEKGIHIWDGNASRDYLDGIGLKDREEGDLGPVY 386
TK+VF R V+ ELLWFISG T+ L E GI IWDGN SR++LD +GL RE GDLGPVY
Sbjct: 97 TKRVFLRAVIAELLWFISGCTSSIPLSEAGIKIWDGNGSREFLDKVGLGHREVGDLGPVY 156
Query: 387 GFQWRHFGARYTDMHADYTGQGFDQLLDVI 416
GFQWRHFGA Y D DYTGQG DQL +V+
Sbjct: 157 GFQWRHFGAEYIDAKTDYTGQGVDQLAEVV 186