Jatropha Genome Database
- JcCA0027761.10
BLASTP 2.2.23 [Feb-03-2010]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Altschul, Stephen F.,
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= JcCA0027761.10 - phase: 0
(411 letters)
Database: TAIR9_pep
33,410 sequences; 13,434,913 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AT3G48730.1 | Symbols: GSA2 | GSA2 (glutamate-1-semialdehyde 2,1... 711 0.0
AT5G63570.1 | Symbols: GSA1 | GSA1 (GLUTAMATE-1-SEMIALDEHYDE-2,1... 706 0.0
AT5G46180.1 | Symbols: DELTA-OAT | delta-OAT; ornithine-oxo-acid... 102 4e-22
AT1G80600.1 | Symbols: WIN1 | WIN1 (HOPW1-1-INTERACTING 1); N2-a... 95 8e-20
AT4G39660.1 | Symbols: AGT2 | AGT2 (ALANINE:GLYOXYLATE AMINOTRAN... 72 8e-13
AT3G08860.1 | Symbols: | alanine--glyoxylate aminotransferase, ... 72 9e-13
AT3G22200.1 | Symbols: POP2, GABA-T, HER1 | POP2 (POLLEN-PISTIL ... 71 1e-12
AT2G38400.1 | Symbols: AGT3 | AGT3 (ALANINE:GLYOXYLATE AMINOTRAN... 60 2e-09
>AT3G48730.1 | Symbols: GSA2 | GSA2 (glutamate-1-semialdehyde
2,1-aminomutase 2); catalytic/ glutamate-1-semialdehyde
2,1-aminomutase/ pyridoxal phosphate binding /
transaminase | chr3:18049697-18051550 FORWARD
Length = 472
Score = 711 bits (1836), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 340/411 (82%), Positives = 371/411 (90%)
Query: 1 MPGGVNSPVRAFKSVGGQPIVMDSVKGSRMWDIDGNEYIDYVGSWGPAIIGHADDQVLAA 60
MPGGVNSPVRAFKSVGGQP+VMDS KGSR+ DIDGNEYIDYVGSWGPAIIGHADD+VLAA
Sbjct: 62 MPGGVNSPVRAFKSVGGQPVVMDSAKGSRIRDIDGNEYIDYVGSWGPAIIGHADDEVLAA 121
Query: 61 LAETMKKGTSFGAPCLLENVLAEMVIKAVPSIEMVRFVNSGTEACMGVLRLARAYTRREK 120
LAETMKKGTSFGAPCLLENVLAEMVI AVPSIEMVRFVNSGTEACMGVLRLARA+T ++K
Sbjct: 122 LAETMKKGTSFGAPCLLENVLAEMVISAVPSIEMVRFVNSGTEACMGVLRLARAFTGKQK 181
Query: 121 LIKFEGCYHGHADPFLVKAGSGVATLGLPDSPGVPKAATYETLTAPFNDLAAVEKLFETN 180
IKFEGCYHGHA+ FLVKAGSGVATLGLPDSPGVPKAAT +TLTAP+ND+AAVEKLFE N
Sbjct: 182 FIKFEGCYHGHANSFLVKAGSGVATLGLPDSPGVPKAATSDTLTAPYNDIAAVEKLFEAN 241
Query: 181 KGEIAAIILEPVVGNSGFVPPKPEFLNAIRKVTKENDALLIFDEVMTGFRLSYGGAQEYF 240
KGEIAAIILEPVVGNSGF+ PKPEF+ IR++TK+N ALLIFDEVMTGFRL+YGGAQEYF
Sbjct: 242 KGEIAAIILEPVVGNSGFITPKPEFIEGIRRITKDNGALLIFDEVMTGFRLAYGGAQEYF 301
Query: 241 GITPDXXXXXXXXXXXXPVGAYGGRREIMEMVAPAGPMYQAGTLSGNPLAMTAGIQTLKR 300
GITPD PVGAYGGRR+IMEMVAPAGPMYQAGTLSGNPLAMTAGI TLKR
Sbjct: 302 GITPDLTTLGKIIGGGLPVGAYGGRRDIMEMVAPAGPMYQAGTLSGNPLAMTAGIHTLKR 361
Query: 301 LQEPGSYEYLDKITGELVQGILEAGKEAGHAICGENIRGMFGFFFTEGPVHNFADAKKSD 360
L +PG+YEYLDKIT EL GILEAGK+ GHA+CG I GMFGFFFTEGPV++F+DAKKSD
Sbjct: 362 LSQPGTYEYLDKITKELTNGILEAGKKTGHAMCGGYISGMFGFFFTEGPVYDFSDAKKSD 421
Query: 361 TAKFARFFQGMLEEGVYFAPSQFEAGFTSLAHTAADVQHTISAAEKVFRQI 411
T KF +FF+GMLEEGVY APSQFEAGFTSLAHT+ D+Q TI+AAEKV ++
Sbjct: 422 TEKFGKFFRGMLEEGVYLAPSQFEAGFTSLAHTSEDIQFTIAAAEKVLSRL 472
>AT5G63570.1 | Symbols: GSA1 | GSA1
(GLUTAMATE-1-SEMIALDEHYDE-2,1-AMINOMUTASE);
glutamate-1-semialdehyde 2,1-aminomutase |
chr5:25451957-25453620 FORWARD
Length = 474
Score = 706 bits (1821), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 336/411 (81%), Positives = 369/411 (89%)
Query: 1 MPGGVNSPVRAFKSVGGQPIVMDSVKGSRMWDIDGNEYIDYVGSWGPAIIGHADDQVLAA 60
MPGGVNSPVRAFKSVGGQP+++DSVKGS+MWDIDGNEYIDYVGSWGPAIIGHADD+VLAA
Sbjct: 64 MPGGVNSPVRAFKSVGGQPVLIDSVKGSKMWDIDGNEYIDYVGSWGPAIIGHADDEVLAA 123
Query: 61 LAETMKKGTSFGAPCLLENVLAEMVIKAVPSIEMVRFVNSGTEACMGVLRLARAYTRREK 120
LAETMKKGTSFGAPCLLENVLAEMVI AVPSIEMVRFVNSGTEACMGVLRLARA+T +EK
Sbjct: 124 LAETMKKGTSFGAPCLLENVLAEMVISAVPSIEMVRFVNSGTEACMGVLRLARAFTNKEK 183
Query: 121 LIKFEGCYHGHADPFLVKAGSGVATLGLPDSPGVPKAATYETLTAPFNDLAAVEKLFETN 180
IKFEGCYHGHA+ FLVKAGSGVATLGLPDSPGVPKAAT +TLTAP+NDL AVEKLF +
Sbjct: 184 FIKFEGCYHGHANAFLVKAGSGVATLGLPDSPGVPKAATSDTLTAPYNDLEAVEKLFAAH 243
Query: 181 KGEIAAIILEPVVGNSGFVPPKPEFLNAIRKVTKENDALLIFDEVMTGFRLSYGGAQEYF 240
KGEI+A+ILEPVVGNSGF+PP PEF+N +R++TK+N LLIFDEVMTGFRL+YGGAQEYF
Sbjct: 244 KGEISAVILEPVVGNSGFIPPTPEFINGLRQLTKDNGVLLIFDEVMTGFRLAYGGAQEYF 303
Query: 241 GITPDXXXXXXXXXXXXPVGAYGGRREIMEMVAPAGPMYQAGTLSGNPLAMTAGIQTLKR 300
GITPD PVGAYGGRR+IMEMVAPAGPMYQAGTLSGNPLAMTAGI TLKR
Sbjct: 304 GITPDLTTLGKIIGGGLPVGAYGGRRDIMEMVAPAGPMYQAGTLSGNPLAMTAGIHTLKR 363
Query: 301 LQEPGSYEYLDKITGELVQGILEAGKEAGHAICGENIRGMFGFFFTEGPVHNFADAKKSD 360
L++ G+YEYLDKIT EL GILEAGK+ GH +CG I GMFGFFF EGPV+NFAD+KKSD
Sbjct: 364 LKQAGTYEYLDKITKELTNGILEAGKKTGHPMCGGYISGMFGFFFAEGPVYNFADSKKSD 423
Query: 361 TAKFARFFQGMLEEGVYFAPSQFEAGFTSLAHTAADVQHTISAAEKVFRQI 411
T KF RFF+GMLEEGVYFAPSQFEAGFTSLAHT D+Q TI+AAE+V +I
Sbjct: 424 TEKFGRFFRGMLEEGVYFAPSQFEAGFTSLAHTPEDIQLTIAAAERVLSRI 474
>AT5G46180.1 | Symbols: DELTA-OAT | delta-OAT; ornithine-oxo-acid
transaminase | chr5:18718766-18721271 REVERSE
Length = 475
Score = 102 bits (254), Expect = 4e-22, Method: Compositional matrix adjust.
Identities = 89/337 (26%), Positives = 143/337 (42%), Gaps = 25/337 (7%)
Query: 19 PIVMDSVKGSRMWDIDGNEYIDYVGSWGPAIIGHADDQVLAALAETMKKGTSFGAPCLLE 78
P+V GS +WD +G YID++ ++ GH +++ AL E ++K T +
Sbjct: 59 PVVFSRANGSTIWDPEGKRYIDFLAAYSAVNQGHCHPKIMKALQEQVEKLTLSSRAFYND 118
Query: 79 N--VLAEMVIKAVPSIEMVRFVNSGTEACMGVLRLARAYTRREK--------LIKFEGCY 128
V AE + +MV +N+G E L+LAR + +K ++ GC+
Sbjct: 119 KFPVFAERLTNMF-GYDMVLPMNTGAEGVETALKLARKWGHEKKNIPKDEAIIVSCCGCF 177
Query: 129 HGHADPFLVKAGSGVATLGL-PDSPGVPKAATYETLTAPFNDLAAVEKLFETNKGEIAAI 187
HG + + AT G P PG L F D ++EK+F+ IA
Sbjct: 178 HGRTLAIVSMSCDNDATRGFGPLLPG--------NLKVDFGDADSLEKIFKEKGDRIAGF 229
Query: 188 ILEPVVGNSGFVPPKPEFLNAIRKVTKENDALLIFDEVMTGF-RLSYGGAQEYFGITPDX 246
+ EP+ G +G + P +L A+R++ + + L+I DEV +G R A ++ I PD
Sbjct: 230 LFEPIQGEAGVIIPPDGYLKAVRELCTKYNVLMIADEVQSGLARSGKMLACDWEEIRPDM 289
Query: 247 XXX-XXXXXXXXPVGAYGGRREIMEMVAPAGPMYQAGTLSGNPLAMTAGIQTLKRLQEPG 305
PV A +++M + P T GNPLA + +L + E
Sbjct: 290 VILGKALGGGVIPVSAVLADKDVMLHIKPG---QHGSTFGGNPLASAVAMASLDVIVEEK 346
Query: 306 SYEYLDKITGELVQGILEAGKEAGHAICGENIRGMFG 342
E + EL + E K+ I RG+F
Sbjct: 347 LVERSASLGEELRIQLNEIKKQFPKYIKEVRGRGLFN 383
>AT1G80600.1 | Symbols: WIN1 | WIN1 (HOPW1-1-INTERACTING 1);
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase/
catalytic/ pyridoxal phosphate binding / transaminase |
chr1:30298675-30300513 REVERSE
Length = 457
Score = 94.7 bits (234), Expect = 8e-20, Method: Compositional matrix adjust.
Identities = 83/310 (26%), Positives = 128/310 (41%), Gaps = 49/310 (15%)
Query: 19 PIVMDSVKGSRMWDIDGNEYIDYVGSWGPAIIGHADDQVLAALAETMKKGTSFGAPCLLE 78
P+V+ S KG +++D +G EY+D +GH D L A+ E
Sbjct: 77 PVVLSSGKGCKLFDPEGKEYLDCASGIAVNALGHGDPDWLRAVTEQA------------- 123
Query: 79 NVLAEM--VIKAVPSIEMVR------------FVNSGTEACMGVLRLARAYTR----REK 120
VLA + V +P IE+ + F NSGTEA ++ +R + R +K
Sbjct: 124 GVLAHVSNVYYTIPQIELAKRLVASSFADRVFFCNSGTEANEAAIKFSRKFQRFTHPEDK 183
Query: 121 -----LIKFEGCYHGHADPFLVKAGSGVATLGLPDSPGVPKAATYETLTAPFNDLAAVEK 175
I F +HG L A + P P +P E + ++ A
Sbjct: 184 EVATGFIAFTNSFHGRTLGAL--ALTSKEQYRTPFEPIMPGVTFLE-----YGNIQAATD 236
Query: 176 LFETNKGEIAAIILEPVVGNSGFVPPKPEFLNAIRKVTKENDALLIFDEVMTGF-RLSYG 234
L + G+IAA+ +EP+ G G EFL ++R +LL+FDEV G R
Sbjct: 237 LIRS--GKIAAVFVEPIQGEGGIYSATKEFLQSLRSACDAAGSLLVFDEVQCGLGRTGLM 294
Query: 235 GAQEYFGITPDXXXXXXXXXXXXPVGAYGGRREIMEMVAPAGPMYQAGTLSGNPLAMTAG 294
A E FG+TPD P+GA ++ E + T +G+PL +A
Sbjct: 295 WAYEAFGVTPDIMTVAKPLAGGLPIGAVLVTEKVAETINYGD---HGSTFAGSPLVCSAA 351
Query: 295 IQTLKRLQEP 304
I + ++ +P
Sbjct: 352 IAVMDKVSKP 361
>AT4G39660.1 | Symbols: AGT2 | AGT2 (ALANINE:GLYOXYLATE
AMINOTRANSFERASE 2); alanine-glyoxylate transaminase/
catalytic/ pyridoxal phosphate binding / transaminase |
chr4:18406797-18409262 FORWARD
Length = 476
Score = 71.6 bits (174), Expect = 8e-13, Method: Compositional matrix adjust.
Identities = 76/341 (22%), Positives = 139/341 (40%), Gaps = 34/341 (9%)
Query: 18 QPIVMDSVKGSRMWDIDGNEYIDYVGSWGPAIIGHADDQVLAALAET---MKKGTSFGAP 74
+P+ + K ++D G Y+D GH +L A+ E ++ T+
Sbjct: 77 KPLNIVEGKMQYLYDESGRRYLDAFAGIVTVSCGHCHPDILNAITEQSKLLQHATTIYLH 136
Query: 75 CLLENVLAEMVIKAVPSIEMVRFVNSGTEACMGVLRLARAYTRREKLIKFEGCYHGHADP 134
+ + + K ++++V FVNSG+EA + +AR YT ++I YHG +
Sbjct: 137 HAIGDFAEALAAKMPGNLKVVYFVNSGSEANELAMMMARLYTGSLEMISLRNAYHGGSSN 196
Query: 135 FLVKAGSGVATLGLPDSPGVPKAATYETLTA-PFNDLAAVE-KLFETN---------KGE 183
+ G+ L P +P+ + + P+ + + L+ + G+
Sbjct: 197 TI-----GLTALNTWKYP-LPQGEIHHVVNPDPYRGVFGSDGSLYAKDVHDHIEYGTSGK 250
Query: 184 IAAIILEPVVGNSGFVPPKPEFLNAIRKVTKENDALLIFDEVMTGFRLSYGGAQEYFG-- 241
+A I E + G G V P +L ++ ++ + + I DEV TGF + Y+G
Sbjct: 251 VAGFIAETIQGVGGAVELAPGYLKSVYEIVRNAGGVCIADEVQTGFGRT---GSHYWGFQ 307
Query: 242 ---ITPDXXXXXXXXXXXXPVGAYGGRREIMEMVAPAGPMYQAGTLSGNPLAMTAGIQTL 298
+ PD P+GA EI ++A T GNP+ G+ L
Sbjct: 308 TQDVVPDIVTMAKGIGNGLPLGAVVTTPEIASVLASK---ILFNTFGGNPVCSAGGLAVL 364
Query: 299 KRLQEPGSYEYLDKITGELVQGILEAGKEAGHAICGENIRG 339
+ + E+ ++ L+Q + + K H I G+ +RG
Sbjct: 365 NVIDKEKRQEHCAEVGSHLIQRLKDVQKR--HDIIGD-VRG 402
>AT3G08860.1 | Symbols: | alanine--glyoxylate aminotransferase,
putative / beta-alanine-pyruvate aminotransferase,
putative / AGT, putative | chr3:2696754-2699087 REVERSE
Length = 481
Score = 71.6 bits (174), Expect = 9e-13, Method: Compositional matrix adjust.
Identities = 73/297 (24%), Positives = 121/297 (40%), Gaps = 17/297 (5%)
Query: 19 PIVMDSVKGSRMWDIDGNEYIDYVGSWGPAIIGHADDQVLAALAETMKKGTSFGAPCLLE 78
P+ + K ++D +G Y+D G GH +V+ ++ + +K L
Sbjct: 83 PLNIVEAKMQYVFDENGRRYLDAFGGIATVSCGHCHPEVVNSVVKQLKLINHSTILYLNH 142
Query: 79 NV--LAEMVIKAVP-SIEMVRFVNSGTEACMGVLRLARAYTRREKLIKFEGCYHGHADPF 135
+ AE ++ +P +++V F NSGTEA + +AR YT ++ YHG+A
Sbjct: 143 TISDFAEALVSTLPGDLKVVFFTNSGTEANELAMMMARLYTGCNDIVSLRNSYHGNAAAT 202
Query: 136 LVKAGSGVATLGLPDSPGVPKAATYETLTAPFND-----LAAVEKLFE-TNKGEIAAIIL 189
+ + S GV A + F + V L + G++A I
Sbjct: 203 MGATAQSNWKFNVVQS-GVHHAINPDPYRGIFGSDGEKYASDVHDLIQFGTSGQVAGFIG 261
Query: 190 EPVVGNSGFVPPKPEFLNAIRKVTKENDALLIFDEVMTGFRLS---YGGAQEYFGITPDX 246
E + G G V P +L A + ++ + I DEV +GF + + G Q + G+ PD
Sbjct: 262 ESIQGVGGIVELAPGYLPAAYDIVRKAGGVCIADEVQSGFARTGTHFWGFQSH-GVIPDI 320
Query: 247 XXXXXXXXXXXPVGAYGGRREIMEMVAPAGPMYQAGTLSGNPLAMTAGIQTLKRLQE 303
P+GA EI +++ T GNP+ AG L+ L E
Sbjct: 321 VTMAKGIGNGIPLGAVVTTPEIAGVLSRRSYF---NTFGGNPMCTAAGHAVLRVLHE 374
>AT3G22200.1 | Symbols: POP2, GABA-T, HER1 | POP2 (POLLEN-PISTIL
INCOMPATIBILITY 2); 4-aminobutyrate transaminase/
4-aminobutyrate:pyruvate transaminase |
chr3:7835286-7838863 FORWARD
Length = 504
Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust.
Identities = 90/360 (25%), Positives = 155/360 (43%), Gaps = 42/360 (11%)
Query: 12 FKSVGGQPIVMDSVKGSRMWDIDGNEYIDYV-GSWGPAIIGHADDQVLAALAE--TMKKG 68
++S P+V+ +GS ++D G +Y+D + G W A+ G+ V AA+ + T+
Sbjct: 63 WQSADLDPLVIAKSEGSYVYDDTGKKYLDSLAGLWCTALGGNEPRLVSAAVEQLNTLPFY 122
Query: 69 TSFGAPCLLENV-LAEMVIKAVPSIEMVR--FVNSGTEACMGVLRLARAYTR------RE 119
SF ++ LA+++++ + +M + F + G++A ++L Y ++
Sbjct: 123 HSFWNRTTKPSLDLAKVLLEMFTANKMAKAFFTSGGSDANDTQVKLVWYYNNALGRPEKK 182
Query: 120 KLIKFEGCYHGHADPFLVKAG-SGVATL----GLP-------DSPG-----VPKAATYET 162
K I + YHG L+ A SG+ L LP D P +P E
Sbjct: 183 KFIARKKSYHGST---LISASLSGLPPLHQNFDLPAPFVLHTDCPHYWRFHLPGETEEEF 239
Query: 163 LTAPFNDLAAVEKLFETNKGEIAAIILEPVVGNSGFVPPKPEFLNAIRKVTKENDALLIF 222
T +L + + + I A I EPV+G G +PP + ++ V K+ D L I
Sbjct: 240 STRLAKNLEDL--IIKEGPETIGAFIAEPVMGAGGVIPPPATYFEKVQAVVKKYDILFIA 297
Query: 223 DEVMTGF-RLSYGGAQEYFGITPDXXXXXXXXXXX-XPVGAYGGRREIMEMV----APAG 276
DEV+ F RL + + I PD P+GA +E+ +++ + G
Sbjct: 298 DEVICAFGRLGTMFGCDKYNIKPDLVTLAKALSSAYMPIGAILMSQEVADVINSHSSKLG 357
Query: 277 PMYQAGTLSGNPLAMTAGIQTLKRLQEPGSYEYLDKITGELVQGILEAGKEAGHAICGEN 336
T SG+P++ I+ LK +E EY+ K+ G+ +G I GE
Sbjct: 358 VFSHGFTYSGHPVSCAVAIEALKIYKERNIPEYVAKVAPRFQDGV--KAFASGSPIIGET 415
>AT2G38400.1 | Symbols: AGT3 | AGT3 (ALANINE:GLYOXYLATE
AMINOTRANSFERASE 3); alanine-glyoxylate transaminase/
catalytic/ pyridoxal phosphate binding / transaminase |
chr2:16083779-16085974 FORWARD
Length = 477
Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 84/340 (24%), Positives = 134/340 (39%), Gaps = 33/340 (9%)
Query: 18 QPIVMDSVKGSRMWDIDGNEYIDYVGSWGPAIIGHADDQVLAALAETMKKGTSFGAPCLL 77
+P+ + K ++D G Y+D GH V+ + +K+ L
Sbjct: 79 KPLNIVDGKMQYLFDESGRRYLDAFAGIAVVNCGHCHPDVVEPVINQIKR-LQHPTVLYL 137
Query: 78 ENVLA---EMVIKAVP-SIEMVRFVNSGTEACMGVLRLARAYTRREKLIKFEGCYHGHAD 133
+ +A E + +P +++V F NSGTEA L +A+ YT + ++ YHG+A
Sbjct: 138 NHAIADFSEALASKLPGDLKVVFFTNSGTEANELALMMAKLYTGCQDIVAVRNGYHGNAA 197
Query: 134 PFLVKAGSGVATLGLPDSPGVPKAATYETLTAPF--------NDLAAVEKLFETNKGEIA 185
+ G + + + V A + F DL + + T G IA
Sbjct: 198 ATMGATGQSMWKFNVVQN-SVHHALNPDPYRGVFGSDGEKYAKDLQDLIQYGTT--GHIA 254
Query: 186 AIILEPVVGNSGFVPPKPEFLNAIRKVTKENDALLIFDEVMTGF-RLSYGGAQEYFGITP 244
I E + G G V P +L+A K+ L I DEV +GF R E + P
Sbjct: 255 GFICEAIQGVGGIVELAPGYLSAAYDTVKKAGGLFIADEVQSGFARTGNFWGFEAHNVVP 314
Query: 245 DXXXXXXXXXXXXPVGAYGGRREIMEMVAPAGPMYQAGTLSGNPLAMTAGIQTL-----K 299
D P+GA EI ++ T GN ++ TAG+ L +
Sbjct: 315 DIVTMAKGIGNGFPLGAVVTTPEIAGVLTRRSYF---NTFGGNSVSTTAGLAVLNVIEKE 371
Query: 300 RLQEPGSYEYLDKITGELVQGILEAGKEAGHAICGENIRG 339
+LQE + + G ++ L KE H I G+ +RG
Sbjct: 372 KLQENAA------MVGSYLKEKLTQLKEK-HEIIGD-VRG 403