# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/ah04470.fasta.nr -Q ../query/KIAA1941.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1941, 1233 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7825239 sequences Expectation_n fit: rho(ln(x))= 5.4594+/-0.000188; mu= 12.9166+/- 0.011 mean_var=78.9344+/-15.453, 0's: 41 Z-trim: 53 B-trim: 955 in 2/65 Lambda= 0.144358 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 40, opt: 28, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|222079962|dbj|BAH16622.1| RUN and TBC1 domain-c (1165) 7818 1638.8 0 gi|148612875|ref|NP_001091968.1| RUN and TBC1 doma (1032) 6072 1275.1 0 gi|90577164|ref|NP_597711.1| RUN and TBC1 domain c (1087) 4034 850.7 0 gi|114685512|ref|XP_001171390.1| PREDICTED: RUN an (1087) 4014 846.5 0 gi|148537240|dbj|BAF63511.1| small G protein signa (1093) 3150 666.6 2.3e-188 gi|73995364|ref|XP_543450.2| PREDICTED: similar to (1178) 3105 657.2 1.6e-185 gi|149063653|gb|EDM13976.1| RUN and TBC1 domain co ( 923) 3081 652.2 4.3e-184 gi|187951845|gb|AAI38051.1| Small G protein signal (1093) 3060 647.8 1e-182 gi|148688001|gb|EDL19948.1| RUN and TBC1 domain co (1094) 3060 647.8 1e-182 gi|74199711|dbj|BAE41515.1| unnamed protein produc (1031) 3050 645.7 4.1e-182 gi|26343543|dbj|BAC35428.1| unnamed protein produc (1093) 3046 644.9 7.6e-182 gi|145566946|sp|Q8BPQ7.2|SGSM1_MOUSE RecName: Full (1093) 3046 644.9 7.6e-182 gi|148688002|gb|EDL19949.1| RUN and TBC1 domain co (1090) 3044 644.5 1e-181 gi|119580084|gb|EAW59680.1| hCG41205, isoform CRA_ ( 537) 3033 642.0 2.8e-181 gi|145566945|sp|Q2NKQ1.2|SGSM1_HUMAN RecName: Full (1148) 2933 621.4 9.6e-175 gi|114685508|ref|XP_520648.2| PREDICTED: RUN and T (1148) 2921 618.9 5.4e-174 gi|74198399|dbj|BAE39683.1| unnamed protein produc ( 806) 2655 563.4 2e-157 gi|212518510|gb|EEB20263.1| run and tbc1 domain-co (1009) 2530 537.4 1.6e-149 gi|157423252|gb|AAI53363.1| LOC100127590 protein [ ( 500) 2301 489.5 2.1e-135 gi|126324795|ref|XP_001378248.1| PREDICTED: simila (1206) 2031 433.6 3.5e-118 gi|194043131|ref|XP_001926987.1| PREDICTED: small (1261) 2027 432.7 6.5e-118 gi|194214168|ref|XP_001496226.2| PREDICTED: small (1195) 2022 431.7 1.3e-117 gi|119909460|ref|XP_593709.3| PREDICTED: similar t (1248) 2015 430.2 3.7e-117 gi|122890911|emb|CAM13110.1| novel protein similar (1353) 1577 339.0 1.1e-89 gi|189518975|ref|XP_001919528.1| PREDICTED: simila (1378) 1577 339.1 1.1e-89 gi|189524221|ref|XP_001918975.1| PREDICTED: simila (1432) 1532 329.7 7.8e-87 gi|119580085|gb|EAW59681.1| hCG41205, isoform CRA_ ( 809) 1527 328.5 1e-86 gi|47226500|emb|CAG08516.1| unnamed protein produc (1192) 1507 324.4 2.5e-85 gi|114665753|ref|XP_511260.2| PREDICTED: RUN and T ( 642) 1482 319.0 5.7e-84 gi|194107949|gb|EDW29992.1| GL15794 [Drosophila pe (1216) 1413 304.9 2e-79 gi|47224924|emb|CAG06494.1| unnamed protein produc (1121) 1392 300.5 3.9e-78 gi|118100381|ref|XP_415919.2| PREDICTED: similar t (1045) 1360 293.8 3.7e-76 gi|115715456|ref|XP_788522.2| PREDICTED: similar t (1289) 1354 292.6 1e-75 gi|210111729|gb|EEA59523.1| hypothetical protein B ( 810) 1337 288.9 8.4e-75 gi|210083188|gb|EEA31813.1| hypothetical protein B (1089) 1335 288.6 1.4e-74 gi|126314245|ref|XP_001372048.1| PREDICTED: simila (1054) 1334 288.4 1.6e-74 gi|149053374|gb|EDM05191.1| RUN and TBC1 domain co (1005) 1333 288.1 1.8e-74 gi|145566944|sp|Q80U12.2|SGSM2_MOUSE RecName: Full (1005) 1332 287.9 2e-74 gi|56205385|emb|CAI24248.1| small G protein signal (1050) 1332 287.9 2.1e-74 gi|145566943|sp|O43147.4|SGSM2_HUMAN RecName: Full (1006) 1326 286.7 4.9e-74 gi|119610953|gb|EAW90547.1| RUN and TBC1 domain co (1006) 1326 286.7 4.9e-74 gi|148612795|ref|NP_055668.2| RUN and TBC1 domain (1051) 1326 286.7 5e-74 gi|119610952|gb|EAW90546.1| RUN and TBC1 domain co (1051) 1326 286.7 5e-74 gi|119610951|gb|EAW90545.1| RUN and TBC1 domain co (1006) 1322 285.9 8.7e-74 gi|194160328|gb|EDW75229.1| GK19804 [Drosophila wi (1263) 1317 284.9 2.1e-73 gi|24659650|gb|AAH39204.1| Small G protein signali (1051) 1314 284.2 2.8e-73 gi|190650263|gb|EDV47541.1| GG19685 [Drosophila er (1210) 1311 283.6 4.9e-73 gi|73967381|ref|XP_537773.2| PREDICTED: similar to (1052) 1299 281.1 2.5e-72 gi|157017752|gb|EAA08470.4| AGAP003198-PA [Anophel (1148) 1292 279.6 7.3e-72 gi|193896279|gb|EDV95145.1| GH17732 [Drosophila gr (1209) 1286 278.4 1.8e-71 >>gi|222079962|dbj|BAH16622.1| RUN and TBC1 domain-conta (1165 aa) initn: 7818 init1: 7818 opt: 7818 Z-score: 8791.7 bits: 1638.8 E(): 0 Smith-Waterman score: 7818; 100.000% identity (100.000% similar) in 1165 aa overlap (69-1233:1-1165) 40 50 60 70 80 90 KIAA19 SPFGAPIPRSPWSPWTSSPPVTFAFQVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLH :::::::::::::::::::::::::::::: gi|222 MEEAVTRKFVHEDSSHIISFCAAVEACVLH 10 20 30 100 110 120 130 140 150 KIAA19 GLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 GLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKL 40 50 60 70 80 90 160 170 180 190 200 210 KIAA19 PKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 PKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLV 100 110 120 130 140 150 220 230 240 250 260 270 KIAA19 GPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 GPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDD 160 170 180 190 200 210 280 290 300 310 320 330 KIAA19 RPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKSALFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 RPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKSALFE 220 230 240 250 260 270 340 350 360 370 380 390 KIAA19 KVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFWTDPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 KVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFWTDPSA 280 290 300 310 320 330 400 410 420 430 440 450 KIAA19 DELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNSRATLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 DELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNSRATLL 340 350 360 370 380 390 460 470 480 490 500 510 KIAA19 YGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYWDYAMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 YGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYWDYAMT 400 410 420 430 440 450 520 530 540 550 560 570 KIAA19 IRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 IRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLD 460 470 480 490 500 510 580 590 600 610 620 630 KIAA19 PPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVPQDLMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 PPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVPQDLMD 520 530 540 550 560 570 640 650 660 670 680 690 KIAA19 VSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQILSRAFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 VSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQILSRAFY 580 590 600 610 620 630 700 710 720 730 740 750 KIAA19 GWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQELLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 GWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQELLRL 640 650 660 670 680 690 760 770 780 790 800 810 KIAA19 IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQVFES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQVFES 700 710 720 730 740 750 820 830 840 850 860 870 KIAA19 VDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 VDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSV 760 770 780 790 800 810 880 890 900 910 920 930 KIAA19 LDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 LDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMSI 820 830 840 850 860 870 940 950 960 970 980 990 KIAA19 TGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 TGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANE 880 890 900 910 920 930 1000 1010 1020 1030 1040 1050 KIAA19 VSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 VSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHI 940 950 960 970 980 990 1060 1070 1080 1090 1100 1110 KIAA19 EIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 EIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQIL 1000 1010 1020 1030 1040 1050 1120 1130 1140 1150 1160 1170 KIAA19 DSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 DSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIA 1060 1070 1080 1090 1100 1110 1180 1190 1200 1210 1220 1230 KIAA19 LALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK ::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|222 LALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK 1120 1130 1140 1150 1160 >>gi|148612875|ref|NP_001091968.1| RUN and TBC1 domain c (1032 aa) initn: 6072 init1: 6072 opt: 6072 Z-score: 6827.2 bits: 1275.1 E(): 0 Smith-Waterman score: 6469; 86.410% identity (86.496% similar) in 1170 aa overlap (64-1233:21-1032) 40 50 60 70 80 90 KIAA19 CGEQCSPFGAPIPRSPWSPWTSSPPVTFAFQVKQIMEEAVTRKFVHEDSSHIISFCAAVE .::::::::::::::::::::::::::::: gi|148 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVE 10 20 30 40 50 100 110 120 130 140 150 KIAA19 ACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 ACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQE 60 70 80 90 100 110 160 170 180 190 200 210 KIAA19 NVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPIL :::::::::::::::::::::::::::::::::::::::::::: gi|148 NVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKY---------------- 120 130 140 150 220 230 240 250 260 270 KIAA19 ASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSS gi|148 ------------------------------------------------------------ 280 290 300 310 320 330 KIAA19 GSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLK gi|148 ------------------------------------------------------------ 340 350 360 370 380 390 KIAA19 SALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW :::::::::::::::::::::::::::::::::::::: gi|148 ----------------------YEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW 160 170 180 190 400 410 420 430 440 450 KIAA19 TDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 TDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNS 200 210 220 230 240 250 460 470 480 490 500 510 KIAA19 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW 260 270 280 290 300 310 520 530 540 550 560 570 KIAA19 DYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 DYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP 320 330 340 350 360 370 580 590 600 610 620 630 KIAA19 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVP 380 390 400 410 420 430 640 650 660 670 680 690 KIAA19 QDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 QDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQIL 440 450 460 470 480 490 700 710 720 730 740 750 KIAA19 SRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 SRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQ 500 510 520 530 540 550 760 770 780 790 800 810 KIAA19 ELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 ELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSST 560 570 580 590 600 610 820 830 840 850 860 870 KIAA19 QVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 QVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLS 620 630 640 650 660 670 880 890 900 910 920 930 KIAA19 TEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 TEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMD 680 690 700 710 720 730 940 950 960 970 980 990 KIAA19 EFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 EFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVT 740 750 760 770 780 790 1000 1010 1020 1030 1040 1050 KIAA19 TSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 TSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSY 800 810 820 830 840 850 1060 1070 1080 1090 1100 1110 KIAA19 IWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 IWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRS 860 870 880 890 900 910 1120 1130 1140 1150 1160 1170 KIAA19 LIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 LIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHY 920 930 940 950 960 970 1180 1190 1200 1210 1220 1230 KIAA19 VLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 VLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK 980 990 1000 1010 1020 1030 >>gi|90577164|ref|NP_597711.1| RUN and TBC1 domain conta (1087 aa) initn: 5793 init1: 4034 opt: 4034 Z-score: 4533.0 bits: 850.7 E(): 0 Smith-Waterman score: 6349; 82.531% identity (82.612% similar) in 1225 aa overlap (64-1233:21-1087) 40 50 60 70 80 90 KIAA19 CGEQCSPFGAPIPRSPWSPWTSSPPVTFAFQVKQIMEEAVTRKFVHEDSSHIISFCAAVE .::::::::::::::::::::::::::::: gi|905 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVE 10 20 30 40 50 100 110 120 130 140 150 KIAA19 ACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 ACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQE 60 70 80 90 100 110 160 170 180 190 200 210 KIAA19 NVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPIL :::::::::::::::::::::::::::::::::::::::::::: gi|905 NVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKY---------------- 120 130 140 150 220 230 240 250 260 270 KIAA19 ASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSS gi|905 ------------------------------------------------------------ 280 290 300 310 320 330 KIAA19 GSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLK gi|905 ------------------------------------------------------------ 340 350 360 370 380 390 KIAA19 SALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW :::::::::::::::::::::::::::::::::::::: gi|905 ----------------------YEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW 160 170 180 190 400 410 420 430 440 450 KIAA19 TDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 TDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNS 200 210 220 230 240 250 460 470 480 490 500 510 KIAA19 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW 260 270 280 290 300 310 520 530 540 550 560 570 KIAA19 DYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 DYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP 320 330 340 350 360 370 580 590 600 610 620 630 KIAA19 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFV- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVA 380 390 400 410 420 430 KIAA19 ------------------------------------------------------PQDLMD :::::: gi|905 PDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSPKEQPPMPQDLMD 440 450 460 470 480 490 640 650 660 670 680 690 KIAA19 VSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQILSRAFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 VSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQILSRAFY 500 510 520 530 540 550 700 710 720 730 740 750 KIAA19 GWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQELLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 GWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQELLRL 560 570 580 590 600 610 760 770 780 790 800 810 KIAA19 IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQVFES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQVFES 620 630 640 650 660 670 820 830 840 850 860 870 KIAA19 VDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 VDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSV 680 690 700 710 720 730 880 890 900 910 920 930 KIAA19 LDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 LDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMSI 740 750 760 770 780 790 940 950 960 970 980 990 KIAA19 TGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 TGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANE 800 810 820 830 840 850 1000 1010 1020 1030 1040 1050 KIAA19 VSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 VSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHI 860 870 880 890 900 910 1060 1070 1080 1090 1100 1110 KIAA19 EIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 EIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQIL 920 930 940 950 960 970 1120 1130 1140 1150 1160 1170 KIAA19 DSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 DSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIA 980 990 1000 1010 1020 1030 1180 1190 1200 1210 1220 1230 KIAA19 LALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK ::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|905 LALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK 1040 1050 1060 1070 1080 >>gi|114685512|ref|XP_001171390.1| PREDICTED: RUN and TB (1087 aa) initn: 5773 init1: 4014 opt: 4014 Z-score: 4510.5 bits: 846.5 E(): 0 Smith-Waterman score: 6329; 82.204% identity (82.449% similar) in 1225 aa overlap (64-1233:21-1087) 40 50 60 70 80 90 KIAA19 CGEQCSPFGAPIPRSPWSPWTSSPPVTFAFQVKQIMEEAVTRKFVHEDSSHIISFCAAVE .::::::::::::::::::::::::::::: gi|114 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVE 10 20 30 40 50 100 110 120 130 140 150 KIAA19 ACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQE 60 70 80 90 100 110 160 170 180 190 200 210 KIAA19 NVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPIL :::::::::::::::::::::::::::::::::::::::::::: gi|114 NVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKY---------------- 120 130 140 150 220 230 240 250 260 270 KIAA19 ASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSS gi|114 ------------------------------------------------------------ 280 290 300 310 320 330 KIAA19 GSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLK gi|114 ------------------------------------------------------------ 340 350 360 370 380 390 KIAA19 SALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW :::::::::::::::::::::::::::::::::::::: gi|114 ----------------------YEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW 160 170 180 190 400 410 420 430 440 450 KIAA19 TDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNS 200 210 220 230 240 250 460 470 480 490 500 510 KIAA19 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW 260 270 280 290 300 310 520 530 540 550 560 570 KIAA19 DYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP 320 330 340 350 360 370 580 590 600 610 620 630 KIAA19 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFV- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVA 380 390 400 410 420 430 KIAA19 ------------------------------------------------------PQDLMD :::::: gi|114 PDLLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPSRWDTTLPTPSPKEQPPMPQDLMD 440 450 460 470 480 490 640 650 660 670 680 690 KIAA19 VSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQILSRAFY :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: gi|114 VSVSNLPSLWQPSPRKSSCSSCSQSGLADGSSTNGCNHERAPLKLLCDNMKYQILSRAFY 500 510 520 530 540 550 700 710 720 730 740 750 KIAA19 GWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQELLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQELLRL 560 570 580 590 600 610 760 770 780 790 800 810 KIAA19 IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQVFES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQVFES 620 630 640 650 660 670 820 830 840 850 860 870 KIAA19 VDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSV 680 690 700 710 720 730 880 890 900 910 920 930 KIAA19 LDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMSI :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LDAQRNTPPVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMSI 740 750 760 770 780 790 940 950 960 970 980 990 KIAA19 TGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANE :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: gi|114 TGSLDMALPEKDDVVMEGWRSSEAEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANE 800 810 820 830 840 850 1000 1010 1020 1030 1040 1050 KIAA19 VSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHI 860 870 880 890 900 910 1060 1070 1080 1090 1100 1110 KIAA19 EIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 EIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQIL 920 930 940 950 960 970 1120 1130 1140 1150 1160 1170 KIAA19 DSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIA 980 990 1000 1010 1020 1030 1180 1190 1200 1210 1220 1230 KIAA19 LALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK ::::::::::::::::::::::::::::::::::::.:::::::::::::::::: gi|114 LALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQILKLARDLVYKVQTLIENK 1040 1050 1060 1070 1080 >>gi|148537240|dbj|BAF63511.1| small G protein signaling (1093 aa) initn: 4688 init1: 3149 opt: 3150 Z-score: 3538.0 bits: 666.6 E(): 2.3e-188 Smith-Waterman score: 6337; 82.128% identity (82.210% similar) in 1231 aa overlap (64-1233:21-1093) 40 50 60 70 80 90 KIAA19 CGEQCSPFGAPIPRSPWSPWTSSPPVTFAFQVKQIMEEAVTRKFVHEDSSHIISFCAAVE .::::::::::::::::::::::::::::: gi|148 MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVE 10 20 30 40 50 100 110 120 130 140 150 KIAA19 ACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 ACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQE 60 70 80 90 100 110 160 170 180 190 200 210 KIAA19 NVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPIL :::::::::::::::::::::::::::::::::::::::::::: gi|148 NVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKY---------------- 120 130 140 150 220 230 240 250 260 270 KIAA19 ASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSS gi|148 ------------------------------------------------------------ 280 290 300 310 320 330 KIAA19 GSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLK gi|148 ------------------------------------------------------------ 340 350 360 370 380 390 KIAA19 SALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW :::::::::::::::::::::::::::::::::::::: gi|148 ----------------------YEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW 160 170 180 190 400 410 420 430 440 450 KIAA19 TDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 TDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNS 200 210 220 230 240 250 460 470 480 490 500 510 KIAA19 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW 260 270 280 290 300 310 520 530 540 550 560 570 KIAA19 DYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 DYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP 320 330 340 350 360 370 580 590 600 610 620 630 KIAA19 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVP 380 390 400 410 420 430 640 650 660 670 680 690 KIAA19 QDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 QDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQIL 440 450 460 470 480 490 700 710 720 730 740 750 KIAA19 SRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 SRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQ 500 510 520 530 540 550 760 770 780 790 KIAA19 ELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE---------------------- :::::::::::::::::::::::::::::::::::::: gi|148 ELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEAI 560 570 580 590 600 610 800 810 KIAA19 ---------------------------------------SSQSCSSGRQNIRLHSDSSSS ::::::::::::::::::::: gi|148 VRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRLHSDSSSS 620 630 640 650 660 670 820 830 840 850 860 870 KIAA19 TQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 TQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSL 680 690 700 710 720 730 880 890 900 910 920 930 KIAA19 STEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 STEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESM 740 750 760 770 780 790 940 950 960 970 980 990 KIAA19 DEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 DEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAV 800 810 820 830 840 850 1000 1010 1020 1030 1040 1050 KIAA19 TTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 TTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCS 860 870 880 890 900 910 1060 1070 1080 1090 1100 1110 KIAA19 YIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 YIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMR 920 930 940 950 960 970 1120 1130 1140 1150 1160 1170 KIAA19 SLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 SLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAH 980 990 1000 1010 1020 1030 1180 1190 1200 1210 1220 1230 KIAA19 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIEN 1040 1050 1060 1070 1080 1090 KIAA19 K : gi|148 K >>gi|73995364|ref|XP_543450.2| PREDICTED: similar to RUN (1178 aa) initn: 4666 init1: 3094 opt: 3105 Z-score: 3486.9 bits: 657.2 E(): 1.6e-185 Smith-Waterman score: 6070; 77.831% identity (80.884% similar) in 1245 aa overlap (53-1232:25-1111) 30 40 50 60 70 KIAA19 VSKHPKQPERPCGEQCSPFGAPIPRSPWSPWTSSPPVTFAFQ---VKQIMEEAVTRKFVH :.: : . . ::::::::::::::: gi|739 MTFRVTSEKCRASTRKNTSGECEVWSSYRPQASDLTEDGVKQIMEEAVTRKFVH 10 20 30 40 50 80 90 100 110 120 130 KIAA19 EDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQ :::::::::::::::::::::::::::::::::::::::::::::::::.::.::::::: gi|739 EDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEELSHKVQDLEQ 60 70 80 90 100 110 140 150 160 170 180 190 KIAA19 LIESARNQIQGLQENVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYE ::::.::::::::::::::::::.:::::::::::::::::::::::::: gi|739 LIESTRNQIQGLQENVRKLPKLPSLSPLAIKHLWIRTALFEKVLDKIVHY---------- 120 130 140 150 160 200 210 220 230 240 250 KIAA19 KEALLMDPVDGPILASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSP gi|739 ------------------------------------------------------------ 260 270 280 290 300 310 KIAA19 TKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPG gi|739 ------------------------------------------------------------ 320 330 340 350 360 370 KIAA19 YLSLHQTADVMTLKSALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPC :::::::::::::::::::::::::::::::: gi|739 ----------------------------LVENSSKYYEKEALLMDPVDGPILASLLVGPC 170 180 190 380 390 400 410 420 430 KIAA19 ALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPS ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: gi|739 ALEYTKMKTADHFWTDPSADELVQRHRIHSSHLRQDSPTKRPALCIQKRHSSGSMDDRPS 200 210 220 230 240 250 440 450 460 470 480 490 KIAA19 LSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMN :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: gi|739 LSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADIMTLKWTPNQLMN 260 270 280 290 300 310 500 510 520 530 540 550 KIAA19 GSVGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGH ::.::::::.:::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 GSMGDLDYERSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGH 320 330 340 350 360 370 560 570 580 590 600 610 KIAA19 LLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYV :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: gi|739 LLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKEDDEATDYV 380 390 400 410 420 430 620 630 640 650 660 670 KIAA19 FRIIYPGMQSEFVPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERA :::::::::::::::::::::::::::::::::::::::::::::::::.:.:::::::: gi|739 FRIIYPGMQSEFVPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGGSSNGCNHERA 440 450 460 470 480 490 680 690 700 710 720 730 KIAA19 PLKLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARI ::::::::::::::::::::::::::::::::::::::::::::::: :::::.:::::: gi|739 PLKLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDSPCDAGHGLTARI 500 510 520 530 540 550 740 750 760 770 780 790 KIAA19 WEQYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE-------- :::::.::: :::::::::::::::::::::::::::::::::::::::::: gi|739 WEQYLQDSTRYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHAC 560 570 580 590 600 610 KIAA19 -----------------------------------------------------SSQSCSS ::::::: gi|739 YAQTMAEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMMHRDSTISNESSQSCSS 620 630 640 650 660 670 800 810 820 830 840 850 KIAA19 GRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSH :::..::.:::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 GRQHVRLQSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSH 680 690 700 710 720 730 860 870 880 890 900 910 KIAA19 NFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAV ::::::::::::::::::::.:::::.: .::: :.:::: ::::::::.:::::::::: gi|739 NFSSGLSEHSEPSLSTEDSVMDAQRNAPLALRPGDSSVDDGQSSEATTSRDEAPREELAV 740 750 760 770 780 790 920 930 940 950 960 970 KIAA19 QDSLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEP :::::::::::::::::::.:::.:.:::::. ..:::: .::.:::.:.:: ::::::: gi|739 QDSLESDLLANESMDEFMSLTGSMDVALPEKEGAAMEGWGGSEAEKHSQVDSGDNLSEEP 800 810 820 830 840 850 980 990 1000 1010 1020 1030 KIAA19 EMESLFPALASLAVTTSAN-EVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWY ::::::::::::::.:::: :.:::::::::::::::::::::::::::::::::::::: gi|739 EMESLFPALASLAVATSANNEASPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWY 860 870 880 890 900 910 1040 1050 1060 1070 1080 1090 KIAA19 FTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 FTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQN 920 930 940 950 960 970 1100 1110 1120 1130 1140 1150 KIAA19 FPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 FPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFS 980 990 1000 1010 1020 1030 1160 1170 1180 1190 1200 1210 KIAA19 VWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::..:: gi|739 VWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKHILK 1040 1050 1060 1070 1080 1090 1220 1230 KIAA19 LARDLVYKVQTLIENK ::::::::::::::: gi|739 LARDLVYKVQTLIENNIYLAQVLFSGESLKPKRIWLLEESSGVDEPPALLGCDQGAQQLG 1100 1110 1120 1130 1140 1150 >>gi|149063653|gb|EDM13976.1| RUN and TBC1 domain contai (923 aa) initn: 4705 init1: 3067 opt: 3081 Z-score: 3461.3 bits: 652.2 E(): 4.3e-184 Smith-Waterman score: 4943; 74.326% identity (78.140% similar) in 1075 aa overlap (69-1081:1-916) 40 50 60 70 80 90 KIAA19 SPFGAPIPRSPWSPWTSSPPVTFAFQVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLH :::::::::::::::::::::::::::::: gi|149 MEEAVTRKFVHEDSSHIISFCAAVEACVLH 10 20 30 100 110 120 130 140 150 KIAA19 GLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKL ::::::::::::::::::::::::.:::::.::::::.:::::::::::::::::::::: gi|149 GLRRRAAGFLRSNKIAALFMKVGKGFPPAEELSRKVQELEQLIESARNQIQGLQENVRKL 40 50 60 70 80 90 160 170 180 190 200 210 KIAA19 PKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLV ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: gi|149 PKLPNLSPLAIKHLWIRTALFERVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLV 100 110 120 130 140 150 220 230 240 250 260 270 KIAA19 GPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDD :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: gi|149 GPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHLRQDSPTKRPALCIQKRHSSGSMDD 160 170 180 190 200 210 280 290 300 310 320 330 KIAA19 RPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKSALFE :::.::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 RPSISARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLK----- 220 230 240 250 260 340 350 360 370 380 390 KIAA19 KVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFWTDPSA gi|149 ------------------------------------------------------------ 400 410 420 430 440 450 KIAA19 DELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNSRATLL gi|149 ------------------------------------------------------------ 460 470 480 490 500 510 KIAA19 YGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYWDYAMT :::::::::::::::::::::::::.: gi|149 ---------------------------------WTPNQLMNGSVGDLDYEKSVYWDYAVT 270 280 290 520 530 540 550 560 570 KIAA19 IRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 IRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLD 300 310 320 330 340 350 580 590 600 610 620 630 KIAA19 PPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVPQDLMD ::::::::::::::::::::::::.:::::::.::::::::::::::: ::::::::::: gi|149 PPLWSQRGKGKVFPKLRKRSPQGSSESTSSDKEDDEATDYVFRIIYPGTQSEFVPQDLMD 360 370 380 390 400 410 640 650 660 670 680 690 KIAA19 VSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQILSRAFY ::..:::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 VSMNNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQILSRAFY 420 430 440 450 460 470 700 710 720 730 740 750 KIAA19 GWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQELLRL ::::::::::::::::::::::::::::::::::::::: :::::..:::.: ::::::: gi|149 GWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTASIWEQYIQDSTTYPEQELLRL 480 490 500 510 520 530 760 770 780 790 KIAA19 IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE--------------------------- :::::.:::::.:::::::::::::::: :::: gi|149 IYYGGVQPEIRRAVWPFLLGHYQFGMTEMERKEVDEQIHACYAQTMSEWLGCEAIVRQRE 540 550 560 570 580 590 800 810 KIAA19 ----------------------------------SSQSCSSGRQNIRLHSDSSSSTQVFE :::::::::::.::.::::::::::: gi|149 RESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNLRLQSDSSSSTQVFE 600 610 620 630 640 650 820 830 840 850 860 870 KIAA19 SVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDS :::::::.::::: :::.::::::: .::::::::::::::::::::::::::::::::: gi|149 SVDEVEQTEAEGRSEEKHPKIPNGNPANGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDS 660 670 680 690 700 710 880 890 900 910 920 930 KIAA19 VLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMS :::.::. :.:.:: :.::.: ::::::::.:::::::::::::::::::::::..:::: gi|149 VLDVQRSLPAVFRPGDSSVEDGQSSEATTSRDEAPREELAVQDSLESDLLANESLEEFMS 720 730 740 750 760 770 940 950 960 970 980 990 KIAA19 ITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSAN : ::::.:::::: ..:.:: .:..:::.::::::::::::::::::::::::::.::: gi|149 IPGSLDVALPEKDGAMMDGW-PGEADKHGRADSEDNLSEEPEMESLFPALASLAVTSSAN 780 790 800 810 820 830 1000 1010 1020 1030 1040 1050 KIAA19 -EVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQ :.::::::::::::::::::::::::::::::::::.::::: :::::::::::::::: gi|149 NETSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRSYWYFTAANLEKLRNIMCSYIWQ 840 850 860 870 880 890 1060 1070 1080 1090 1100 1110 KIAA19 HIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQ ::::::::::::::::::::::: : gi|149 HIEIGYVQGMCDLLAPLLVILDDGAPVPEAMA 900 910 920 >>gi|187951845|gb|AAI38051.1| Small G protein signaling (1093 aa) initn: 4219 init1: 3051 opt: 3060 Z-score: 3436.7 bits: 647.8 E(): 1e-182 Smith-Waterman score: 5942; 76.867% identity (80.682% similar) in 1232 aa overlap (64-1233:21-1093) 40 50 60 70 80 90 KIAA19 CGEQCSPFGAPIPRSPWSPWTSSPPVTFAFQVKQIMEEAVTRKFVHEDSSHIISFCAAVE .::::::::::::::::::::::::::::: gi|187 MASVPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVE 10 20 30 40 50 100 110 120 130 140 150 KIAA19 ACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQE :::::::::::::::::::::::::::::.:::::.::::::.::::::::::::::::: gi|187 ACVLHGLRRRAAGFLRSNKIAALFMKVGKGFPPAEELSRKVQELEQLIESARNQIQGLQE 60 70 80 90 100 110 160 170 180 190 200 210 KIAA19 NVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPIL :::::::::::::::::::::::::::.:::::::::::::::: gi|187 NVRKLPKLPNLSPLAIKHLWIRTALFERVLDKIVHYLVENSSKY---------------- 120 130 140 150 220 230 240 250 260 270 KIAA19 ASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSS gi|187 ------------------------------------------------------------ 280 290 300 310 320 330 KIAA19 GSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLK gi|187 ------------------------------------------------------------ 340 350 360 370 380 390 KIAA19 SALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW :::::::::::::::::::::::::::::::::::::: gi|187 ----------------------YEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW 160 170 180 190 400 410 420 430 440 450 KIAA19 TDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNS ::::::::::::::::::.:::::::::::::::::::::::::::.::::::::::::: gi|187 TDPSADELVQRHRIHSSHLRQDSPTKRPALCIQKRHSSGSMDDRPSISARDYVESLHQNS 200 210 220 230 240 250 460 470 480 490 500 510 KIAA19 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW 260 270 280 290 300 310 520 530 540 550 560 570 KIAA19 DYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 DYAVTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP 320 330 340 350 360 370 580 590 600 610 620 630 KIAA19 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVP :::::::::::::::::::::::::::::.:::::::.::::::::::::::: :::::: gi|187 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSSESTSSDKEDDEATDYVFRIIYPGTQSEFVP 380 390 400 410 420 430 640 650 660 670 680 690 KIAA19 QDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQIL :::::::..::: ::::::::::::::::::::::.:::::::::::::::::::::::: gi|187 QDLMDVSMNNLPPLWQPSPRKSSCSSCSQSGSADGGSTNGCNHERAPLKLLCDNMKYQIL 440 450 460 470 480 490 700 710 720 730 740 750 KIAA19 SRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQ :::::::::::::::::::::::::::::::::::::::::::: :::.:..:::.: :: gi|187 SRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTASIWEKYIQDSTTYPEQ 500 510 520 530 540 550 760 770 780 790 KIAA19 ELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE---------------------- ::::::::::.:::::.:::::::::::::::: :::: gi|187 ELLRLIYYGGVQPEIRRAVWPFLLGHYQFGMTEMERKEVDEQIHACYAQTMSEWLGCEAI 560 570 580 590 600 610 800 810 KIAA19 ---------------------------------------SSQSCSSGRQNIRLHSDSSSS :::::::::::.::.:::::: gi|187 VRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNLRLQSDSSSS 620 630 640 650 660 670 820 830 840 850 860 870 KIAA19 TQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSL ::::::::::::.::::: :::.::::::: .:::::::::::::::::::::::::::: gi|187 TQVFESVDEVEQTEAEGRSEEKHPKIPNGNPANGTCSPDSGHPSSHNFSSGLSEHSEPSL 680 690 700 710 720 730 880 890 900 910 920 930 KIAA19 STEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESM :::::::::::. :.:.:: :.::.: ::::::::.:::::::::::::::::::::::. gi|187 STEDSVLDAQRSLPAVFRPGDSSVEDGQSSEATTSRDEAPREELAVQDSLESDLLANESL 740 750 760 770 780 790 940 950 960 970 980 990 KIAA19 DEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAV .::::: ::::.:::::: .::.:: .:..: ..::::::::::::::::::::::::: gi|187 EEFMSIPGSLDVALPEKDGAVMDGW-PGEADKPSRADSEDNLSEEPEMESLFPALASLAV 800 810 820 830 840 850 1000 1010 1020 1030 1040 1050 KIAA19 TTSAN-EVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMC :.::: :.::::::::::::::::::::::::::::::::::.::::: ::::::::::: gi|187 TSSANNEASPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRSYWYFTAANLEKLRNIMC 860 870 880 890 900 910 1060 1070 1080 1090 1100 1110 KIAA19 SYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|187 SYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANM 920 930 940 950 960 970 1120 1130 1140 1150 1160 1170 KIAA19 RSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSA ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: gi|187 RSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFSVWETIWAAKHVSSA 980 990 1000 1010 1020 1030 1180 1190 1200 1210 1220 1230 KIAA19 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIE ::::::::::::::::::::::::::::::::::::::::.::.:.::::::.::: ::: gi|187 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNAKQILQLARDLVHKVQILIE 1040 1050 1060 1070 1080 1090 KIAA19 NK :: gi|187 NK >>gi|148688001|gb|EDL19948.1| RUN and TBC1 domain contai (1094 aa) initn: 4219 init1: 3051 opt: 3060 Z-score: 3436.7 bits: 647.8 E(): 1e-182 Smith-Waterman score: 5942; 76.867% identity (80.682% similar) in 1232 aa overlap (64-1233:22-1094) 40 50 60 70 80 90 KIAA19 CGEQCSPFGAPIPRSPWSPWTSSPPVTFAFQVKQIMEEAVTRKFVHEDSSHIISFCAAVE .::::::::::::::::::::::::::::: gi|148 AMASVPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVE 10 20 30 40 50 100 110 120 130 140 150 KIAA19 ACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQE :::::::::::::::::::::::::::::.:::::.::::::.::::::::::::::::: gi|148 ACVLHGLRRRAAGFLRSNKIAALFMKVGKGFPPAEELSRKVQELEQLIESARNQIQGLQE 60 70 80 90 100 110 160 170 180 190 200 210 KIAA19 NVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPIL :::::::::::::::::::::::::::.:::::::::::::::: gi|148 NVRKLPKLPNLSPLAIKHLWIRTALFERVLDKIVHYLVENSSKY---------------- 120 130 140 150 220 230 240 250 260 270 KIAA19 ASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSS gi|148 ------------------------------------------------------------ 280 290 300 310 320 330 KIAA19 GSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLK gi|148 ------------------------------------------------------------ 340 350 360 370 380 390 KIAA19 SALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW :::::::::::::::::::::::::::::::::::::: gi|148 ----------------------YEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW 160 170 180 190 400 410 420 430 440 450 KIAA19 TDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNS ::::::::::::::::::.:::::::::::::::::::::::::::.::::::::::::: gi|148 TDPSADELVQRHRIHSSHLRQDSPTKRPALCIQKRHSSGSMDDRPSISARDYVESLHQNS 200 210 220 230 240 250 460 470 480 490 500 510 KIAA19 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW 260 270 280 290 300 310 520 530 540 550 560 570 KIAA19 DYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 DYAVTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP 320 330 340 350 360 370 580 590 600 610 620 630 KIAA19 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVP :::::::::::::::::::::::::::::.:::::::.::::::::::::::: :::::: gi|148 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSSESTSSDKEDDEATDYVFRIIYPGTQSEFVP 380 390 400 410 420 430 640 650 660 670 680 690 KIAA19 QDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQIL :::::::..::: ::::::::::::::::::::::.:::::::::::::::::::::::: gi|148 QDLMDVSMNNLPPLWQPSPRKSSCSSCSQSGSADGGSTNGCNHERAPLKLLCDNMKYQIL 440 450 460 470 480 490 700 710 720 730 740 750 KIAA19 SRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQ :::::::::::::::::::::::::::::::::::::::::::: :::.:..:::.: :: gi|148 SRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTASIWEKYIQDSTTYPEQ 500 510 520 530 540 550 760 770 780 790 KIAA19 ELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE---------------------- ::::::::::.:::::.:::::::::::::::: :::: gi|148 ELLRLIYYGGVQPEIRRAVWPFLLGHYQFGMTEMERKEVDEQIHACYAQTMSEWLGCEAI 560 570 580 590 600 610 800 810 KIAA19 ---------------------------------------SSQSCSSGRQNIRLHSDSSSS :::::::::::.::.:::::: gi|148 VRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNLRLQSDSSSS 620 630 640 650 660 670 820 830 840 850 860 870 KIAA19 TQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSL ::::::::::::.::::: :::.::::::: .:::::::::::::::::::::::::::: gi|148 TQVFESVDEVEQTEAEGRSEEKHPKIPNGNPANGTCSPDSGHPSSHNFSSGLSEHSEPSL 680 690 700 710 720 730 880 890 900 910 920 930 KIAA19 STEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESM :::::::::::. :.:.:: :.::.: ::::::::.:::::::::::::::::::::::. gi|148 STEDSVLDAQRSLPAVFRPGDSSVEDGQSSEATTSRDEAPREELAVQDSLESDLLANESL 740 750 760 770 780 790 940 950 960 970 980 990 KIAA19 DEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAV .::::: ::::.:::::: .::.:: .:..: ..::::::::::::::::::::::::: gi|148 EEFMSIPGSLDVALPEKDGAVMDGW-PGEADKPSRADSEDNLSEEPEMESLFPALASLAV 800 810 820 830 840 850 1000 1010 1020 1030 1040 1050 KIAA19 TTSAN-EVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMC :.::: :.::::::::::::::::::::::::::::::::::.::::: ::::::::::: gi|148 TSSANNEASPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRSYWYFTAANLEKLRNIMC 860 870 880 890 900 910 1060 1070 1080 1090 1100 1110 KIAA19 SYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 SYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANM 920 930 940 950 960 970 1120 1130 1140 1150 1160 1170 KIAA19 RSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSA ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: gi|148 RSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFSVWETIWAAKHVSSA 980 990 1000 1010 1020 1030 1180 1190 1200 1210 1220 1230 KIAA19 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIE ::::::::::::::::::::::::::::::::::::::::.::.:.::::::.::: ::: gi|148 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNAKQILQLARDLVHKVQILIE 1040 1050 1060 1070 1080 1090 KIAA19 NK :: gi|148 NK >>gi|74199711|dbj|BAE41515.1| unnamed protein product [M (1031 aa) initn: 3219 init1: 3041 opt: 3050 Z-score: 3425.8 bits: 645.7 E(): 4.1e-182 Smith-Waterman score: 4935; 73.529% identity (77.941% similar) in 1088 aa overlap (64-1086:21-949) 40 50 60 70 80 90 KIAA19 CGEQCSPFGAPIPRSPWSPWTSSPPVTFAFQVKQIMEEAVTRKFVHEDSSHIISFCAAVE .::::::::::::::::::::::::::::: gi|741 MASVPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVE 10 20 30 40 50 100 110 120 130 140 150 KIAA19 ACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQE :::::::::::::::::::::::::::::.:::::.::::::.::::::::::::::::: gi|741 ACVLHGLRRRAAGFLRSNKIAALFMKVGKGFPPAEELSRKVQELEQLIESARNQIQGLQE 60 70 80 90 100 110 160 170 180 190 200 210 KIAA19 NVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPIL :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: gi|741 NVRKLPKLPNLSPLAIKHLWIRTALFERVLDKIVHYLVENSSKYYEKEALLMDPVDGPIL 120 130 140 150 160 170 220 230 240 250 260 270 KIAA19 ASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSS :::::::::::::::::::::::::::::::::.::::::.::::::::::::::::::: gi|741 ASLLVGPCALEYTKMKTADHFWTDPSADELVQRRRIHSSHLRQDSPTKRPALCIQKRHSS 180 190 200 210 220 230 280 290 300 310 320 330 KIAA19 GSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLK ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 GSMDDRPSISARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLK 240 250 260 270 280 290 340 350 360 370 380 390 KIAA19 SALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFW gi|741 ------------------------------------------------------------ 400 410 420 430 440 450 KIAA19 TDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNS gi|741 ------------------------------------------------------------ 460 470 480 490 500 510 KIAA19 RATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYW :::::::::::::::::::::: gi|741 --------------------------------------WTPNQLMNGSVGDLDYEKSVYW 300 310 520 530 540 550 560 570 KIAA19 DYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|741 DYAVTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLP 320 330 340 350 360 370 580 590 600 610 620 630 KIAA19 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVP :::::::::::::::::::::::::::::.:::::::.::::::::::::::: :::::: gi|741 HGQLDPPLWSQRGKGKVFPKLRKRSPQGSSESTSSDKEDDEATDYVFRIIYPGTQSEFVP 380 390 400 410 420 430 640 650 660 670 680 690 KIAA19 QDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQIL :::::::..::: ::::::::::::::::::::::.:::::::::::::::::::::::: gi|741 QDLMDVSMNNLPPLWQPSPRKSSCSSCSQSGSADGGSTNGCNHERAPLKLLCDNMKYQIL 440 450 460 470 480 490 700 710 720 730 740 750 KIAA19 SRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQ :::::::::::::::::::::::::::::::::::::::::::: :::.:..:::.: :: gi|741 SRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTASIWEKYIQDSTTYPEQ 500 510 520 530 540 550 760 770 780 790 KIAA19 ELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE---------------------- ::::::::::.:::::.:::::::::::::::: :::: gi|741 ELLRLIYYGGVQPEIRRAVWPFLLGHYQFGMTEMERKEVDEQIHACYAQTMSEWLGCEAI 560 570 580 590 600 610 800 810 KIAA19 ---------------------------------------SSQSCSSGRQNIRLHSDSSSS :::::::::::.::.:::::: gi|741 VRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNLRLQSDSSSS 620 630 640 650 660 670 820 830 840 850 860 870 KIAA19 TQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSL ::::::::::::.::::: :::.::::::: .:::::::::::::::::::::::::::: gi|741 TQVFESVDEVEQTEAEGRSEEKHPKIPNGNPANGTCSPDSGHPSSHNFSSGLSEHSEPSL 680 690 700 710 720 730 880 890 900 910 920 930 KIAA19 STEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESM :::::::::::. :.:.:: :.::.: ::::::::.:::::::::::::::::::::::. gi|741 STEDSVLDAQRSLPAVFRPGDSSVEDGQSSEATTSRDEAPREELAVQDSLESDLLANESL 740 750 760 770 780 790 940 950 960 970 980 990 KIAA19 DEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAV .::::: ::::.:::::: .::.:: .:..: ..::::::::::::::::::::::::: gi|741 EEFMSIPGSLDVALPEKDGAVMDGW-PGEADKPSRADSEDNLSEEPEMESLFPALASLAV 800 810 820 830 840 850 1000 1010 1020 1030 1040 1050 KIAA19 TTSAN-EVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMC :.::: :.::::::::::::::::::::::::::::::::::.::::: ::::::::::: gi|741 TSSANNEASPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRSYWYFTAANLEKLRNIMC 860 870 880 890 900 910 1060 1070 1080 1090 1100 KIAA19 SYIWQHIEIGYVQGMCDLLAPLLVILDDEALAF---SCFTELMKRMNQNFPHGGAMDTHF ::::::::::::::::::::::::::::. ... :: gi|741 SYIWQHIEIGYVQGMCDLLAPLLVILDDDQVSLYSPSCPGTQVVDQAGLELRNPPAFAFP 920 930 940 950 960 970 1110 1120 1130 1140 1150 1160 KIAA19 ANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHV gi|741 MLGLEACATTARLDNWNVSSSLGETSPHRHLTFTLMSTSDRIIPGKCQTSTSHEYKSKTS 980 990 1000 1010 1020 1030 1233 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Fri Mar 6 04:48:36 2009 done: Fri Mar 6 04:52:34 2009 Total Scan time: 1827.040 Total Display time: 1.010 Function used was FASTA [version 34.26.5 April 26, 2007]