# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/ah00647.fasta.nr -Q ../query/KIAA1879.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1879, 995 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7826000 sequences Expectation_n fit: rho(ln(x))= 5.0646+/-0.000184; mu= 14.9277+/- 0.010 mean_var=73.9545+/-14.747, 0's: 28 Z-trim: 36 B-trim: 2799 in 1/65 Lambda= 0.149139 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 39, opt: 27, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|34485553|gb|AAQ73173.1| polycystic kidney disea (1774) 6430 1393.7 0 gi|31335113|gb|AAO32796.1| polycystic kidney disea (2459) 6416 1390.8 0 gi|215274222|sp|Q7Z442.3|PK1L2_HUMAN RecName: Full (2459) 6413 1390.2 0 gi|116006951|ref|NP_443124.3| polycystin 1-like 2 (2459) 6413 1390.2 0 gi|194208830|ref|XP_001916475.1| PREDICTED: simila (2433) 5485 1190.5 0 gi|73957284|ref|XP_546816.2| PREDICTED: similar to (2448) 5241 1138.0 0 gi|81865247|sp|Q7TN88.1|PK1L2_MOUSE RecName: Full= (2461) 4975 1080.8 0 gi|213417890|ref|NP_083962.3| polycystin 1-like 2 (2461) 4975 1080.8 0 gi|114663813|ref|XP_511127.2| PREDICTED: polycysti (1810) 4886 1061.5 0 gi|148679628|gb|EDL11575.1| mCG4315 [Mus musculus] (1198) 4837 1050.8 0 gi|119615945|gb|EAW95539.1| polycystic kidney dise (1694) 4836 1050.7 0 gi|126303740|ref|XP_001380952.1| PREDICTED: simila (2456) 4283 931.9 0 gi|149637003|ref|XP_001508495.1| PREDICTED: simila (2589) 3852 839.2 0 gi|149038284|gb|EDL92644.1| rCG51274 [Rattus norve ( 478) 2662 582.5 1.6e-163 gi|194674740|ref|XP_587680.4| PREDICTED: similar t (1234) 2216 486.9 2.6e-134 gi|189521800|ref|XP_691431.3| PREDICTED: similar t (1924) 2086 459.1 9.5e-126 gi|189521818|ref|XP_001338412.2| PREDICTED: simila (3359) 1911 421.6 3.1e-114 gi|47230426|emb|CAF99619.1| unnamed protein produc (1146) 1611 356.7 3.8e-95 gi|169209430|ref|XP_001724554.1| PREDICTED: simila (1732) 1543 342.2 1.3e-90 gi|113426141|ref|XP_001133467.1| PREDICTED: polycy (1731) 1540 341.6 2e-90 gi|74713456|sp|Q7Z443.1|PK1L3_HUMAN RecName: Full= (1732) 1540 341.6 2e-90 gi|119579608|gb|EAW59204.1| polycystic kidney dise (1256) 1538 341.0 2.2e-90 gi|113426499|ref|XP_001134223.1| PREDICTED: simila (1731) 1538 341.1 2.7e-90 gi|114663595|ref|XP_511095.2| PREDICTED: polycysti (1732) 1536 340.7 3.7e-90 gi|87280852|gb|ABD36565.1| polycystic kidney disea ( 570) 1500 332.6 3.4e-88 gi|124001512|dbj|BAF45379.1| polycystic kidney dis (2151) 1505 334.1 4.4e-88 gi|115583681|ref|NP_001034789.2| polycystic kidney (2201) 1505 334.1 4.5e-88 gi|123786229|sp|Q2EG98.1|PK1L3_MOUSE RecName: Full (2201) 1505 334.1 4.5e-88 gi|31335119|gb|AAO32799.1| polycystic kidney disea (2151) 1499 332.8 1.1e-87 gi|87280846|gb|ABD36562.1| polycystic kidney disea (2191) 1499 332.8 1.1e-87 gi|87280850|gb|ABD36564.1| polycystic kidney disea (1403) 1485 329.7 6.4e-87 gi|73957432|ref|XP_546847.2| PREDICTED: similar to (1752) 1418 315.3 1.6e-82 gi|126305047|ref|XP_001378679.1| PREDICTED: simila (1528) 1396 310.5 3.9e-81 gi|16566422|gb|AAL26499.1|AF422153_1 receptor for (2681) 1360 303.0 1.3e-78 gi|148679480|gb|EDL11427.1| mCG130331 [Mus musculu ( 393) 1323 294.3 7.6e-77 gi|119579606|gb|EAW59202.1| polycystic kidney dise (1232) 1264 282.1 1.2e-72 gi|50802455|ref|XP_428607.1| PREDICTED: similar to ( 219) 1251 278.6 2.2e-72 gi|149038147|gb|EDL92507.1| rCG51374 [Rattus norve ( 371) 1214 270.9 8.3e-70 gi|210102725|gb|EEA50771.1| hypothetical protein B (1610) 1194 267.1 5e-68 gi|189521758|ref|XP_694302.3| PREDICTED: im:715919 ( 592) 1187 265.2 6.6e-68 gi|156223914|gb|EDO44744.1| predicted protein [Nem (1118) 1103 247.4 3e-62 gi|47210630|emb|CAF94444.1| unnamed protein produc ( 383) 1088 243.8 1.2e-61 gi|210126900|gb|EEA74585.1| hypothetical protein B (5553) 1101 247.5 1.3e-61 gi|210106274|gb|EEA54266.1| hypothetical protein B (4844) 1096 246.4 2.5e-61 gi|210112296|gb|EEA60074.1| hypothetical protein B (3860) 1081 243.1 2e-60 gi|48094207|gb|AAT40426.1| receptor for egg jelly (2829) 1069 240.4 9.5e-60 gi|210127225|gb|EEA74908.1| hypothetical protein B (3836) 1070 240.7 1e-59 gi|156228401|gb|EDO49200.1| predicted protein [Nem (1127) 1062 238.6 1.3e-59 gi|156224055|gb|EDO44884.1| predicted protein [Nem (1061) 1055 237.0 3.7e-59 gi|116272456|gb|ABJ97172.1| receptor for egg jelly (3716) 1046 235.5 3.6e-58 >>gi|34485553|gb|AAQ73173.1| polycystic kidney disease 1 (1774 aa) initn: 6422 init1: 6422 opt: 6430 Z-score: 7465.6 bits: 1393.7 E(): 0 Smith-Waterman score: 6430; 97.925% identity (98.548% similar) in 964 aa overlap (30-993:372-1330) 10 20 30 40 50 KIAA18 NKHAEPPMGIKTHPHSDGEAGLPVVQEVWGLPRTLTFSSLPCHLCPHLVARIQPWSWQG ::: :. :. . . ::::::::: gi|344 ASSSQIATVLRLLRVMEHVQTTLLLGKLPGGLPAMLATPSISVY-----TNRIQPWSWQG 350 360 370 380 390 60 70 80 90 100 110 KIAA18 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV 400 410 420 430 440 450 120 130 140 150 160 170 KIAA18 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR 460 470 480 490 500 510 180 190 200 210 220 230 KIAA18 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES 520 530 540 550 560 570 240 250 260 270 280 290 KIAA18 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST 580 590 600 610 620 630 300 310 320 330 340 350 KIAA18 FLVMPNAIDVHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL :::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 FLVMPNAIDIHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL 640 650 660 670 680 690 360 370 380 390 400 410 KIAA18 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA 700 710 720 730 740 750 420 430 440 450 460 470 KIAA18 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV 760 770 780 790 800 810 480 490 500 510 520 530 KIAA18 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL 820 830 840 850 860 870 540 550 560 570 580 590 KIAA18 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR 880 890 900 910 920 930 600 610 620 630 640 650 KIAA18 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS 940 950 960 970 980 990 660 670 680 690 700 710 KIAA18 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR 1000 1010 1020 1030 1040 1050 720 730 740 750 760 770 KIAA18 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFPQHHSHAQALRQLQTLKGGLGVQPGTWA :::::::::::::::::::::::::::::::: : ::::::::::::::::::::::::: gi|344 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFSQPHSHAQALRQLQTLKGGLGVQPGTWA 1060 1070 1080 1090 1100 1110 780 790 800 810 820 830 KIAA18 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV 1120 1130 1140 1150 1160 1170 840 850 860 870 880 890 KIAA18 SFVESVFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 SFVESMFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD 1180 1190 1200 1210 1220 1230 900 910 920 930 940 950 KIAA18 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|344 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ 1240 1250 1260 1270 1280 1290 960 970 980 990 KIAA18 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGKS :::::::::::::::::::::::::::::::::: gi|344 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGFITDGNSKLVGSAQIRQVRVRESSCP 1300 1310 1320 1330 1340 1350 gi|344 LAQQLQASLNGCRTPYSLDAEDMADYGEGWNATTLSAWQYQSQDQRQGYPIWGKLTVYRG 1360 1370 1380 1390 1400 1410 >>gi|31335113|gb|AAO32796.1| polycystic kidney disease 1 (2459 aa) initn: 6408 init1: 6408 opt: 6416 Z-score: 7447.4 bits: 1390.8 E(): 0 Smith-Waterman score: 6416; 97.718% identity (98.444% similar) in 964 aa overlap (30-993:1057-2015) 10 20 30 40 50 KIAA18 NKHAEPPMGIKTHPHSDGEAGLPVVQEVWGLPRTLTFSSLPCHLCPHLVARIQPWSWQG ::: :. :. . . ::::::::: gi|313 ASSSQIATVLRLLRVMEHVQTTLLLGKLPGGLPAMLATPSISVY-----TNRIQPWSWQG 1030 1040 1050 1060 1070 1080 60 70 80 90 100 110 KIAA18 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV 1090 1100 1110 1120 1130 1140 120 130 140 150 160 170 KIAA18 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR 1150 1160 1170 1180 1190 1200 180 190 200 210 220 230 KIAA18 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES 1210 1220 1230 1240 1250 1260 240 250 260 270 280 290 KIAA18 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST 1270 1280 1290 1300 1310 1320 300 310 320 330 340 350 KIAA18 FLVMPNAIDVHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL ::::::::..:::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 FLVMPNAINIHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL 1330 1340 1350 1360 1370 1380 360 370 380 390 400 410 KIAA18 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: gi|313 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGESEPHHLADPDTPVFERGAVDA 1390 1400 1410 1420 1430 1440 420 430 440 450 460 470 KIAA18 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV 1450 1460 1470 1480 1490 1500 480 490 500 510 520 530 KIAA18 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL 1510 1520 1530 1540 1550 1560 540 550 560 570 580 590 KIAA18 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR 1570 1580 1590 1600 1610 1620 600 610 620 630 640 650 KIAA18 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS 1630 1640 1650 1660 1670 1680 660 670 680 690 700 710 KIAA18 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR 1690 1700 1710 1720 1730 1740 720 730 740 750 760 770 KIAA18 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFPQHHSHAQALRQLQTLKGGLGVQPGTWA :::::::::::::::::::::::::::::::: : ::::::::::::::::::::::::: gi|313 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFSQPHSHAQALRQLQTLKGGLGVQPGTWA 1750 1760 1770 1780 1790 1800 780 790 800 810 820 830 KIAA18 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV 1810 1820 1830 1840 1850 1860 840 850 860 870 880 890 KIAA18 SFVESVFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 SFVESMFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD 1870 1880 1890 1900 1910 1920 900 910 920 930 940 950 KIAA18 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|313 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ 1930 1940 1950 1960 1970 1980 960 970 980 990 KIAA18 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGKS :::::::::::::::::::::::::::::::::: gi|313 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGFITDGNSKLVGSAQIRQVRVQESSCP 1990 2000 2010 2020 2030 2040 gi|313 LAQQPQAYLNGCRAPYSLDAEDMADYGEGWNATTLSEWQYQSQDQRQGYPIWGKLTVYRG 2050 2060 2070 2080 2090 2100 >>gi|215274222|sp|Q7Z442.3|PK1L2_HUMAN RecName: Full=Pol (2459 aa) initn: 6405 init1: 6405 opt: 6413 Z-score: 7443.9 bits: 1390.2 E(): 0 Smith-Waterman score: 6413; 97.718% identity (98.444% similar) in 964 aa overlap (30-993:1057-2015) 10 20 30 40 50 KIAA18 NKHAEPPMGIKTHPHSDGEAGLPVVQEVWGLPRTLTFSSLPCHLCPHLVARIQPWSWQG ::: :. :. . . ::::::::: gi|215 ASSSQIATVLRLLRVMEHVQTTLLLGKLPGGLPAMLATPSISVY-----TNRIQPWSWQG 1030 1040 1050 1060 1070 1080 60 70 80 90 100 110 KIAA18 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV 1090 1100 1110 1120 1130 1140 120 130 140 150 160 170 KIAA18 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR 1150 1160 1170 1180 1190 1200 180 190 200 210 220 230 KIAA18 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES 1210 1220 1230 1240 1250 1260 240 250 260 270 280 290 KIAA18 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST 1270 1280 1290 1300 1310 1320 300 310 320 330 340 350 KIAA18 FLVMPNAIDVHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL :::: :::..:::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 FLVMSNAINIHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL 1330 1340 1350 1360 1370 1380 360 370 380 390 400 410 KIAA18 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA 1390 1400 1410 1420 1430 1440 420 430 440 450 460 470 KIAA18 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV 1450 1460 1470 1480 1490 1500 480 490 500 510 520 530 KIAA18 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL 1510 1520 1530 1540 1550 1560 540 550 560 570 580 590 KIAA18 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR 1570 1580 1590 1600 1610 1620 600 610 620 630 640 650 KIAA18 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS 1630 1640 1650 1660 1670 1680 660 670 680 690 700 710 KIAA18 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR 1690 1700 1710 1720 1730 1740 720 730 740 750 760 770 KIAA18 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFPQHHSHAQALRQLQTLKGGLGVQPGTWA :::::::::::::::::::::::::::::::: : ::::::::::::::::::::::::: gi|215 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFSQPHSHAQALRQLQTLKGGLGVQPGTWA 1750 1760 1770 1780 1790 1800 780 790 800 810 820 830 KIAA18 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV 1810 1820 1830 1840 1850 1860 840 850 860 870 880 890 KIAA18 SFVESVFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 SFVESMFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD 1870 1880 1890 1900 1910 1920 900 910 920 930 940 950 KIAA18 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|215 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ 1930 1940 1950 1960 1970 1980 960 970 980 990 KIAA18 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGKS :::::::::::::::::::::::::::::::::: gi|215 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGFITDGNSKLVGSAQIRQVRVQESSCP 1990 2000 2010 2020 2030 2040 gi|215 LAQQPQAYLNGCRAPYSLDAEDMADYGEGWNATTLSEWQYQSQDQRQGYPIWGKLTVYRG 2050 2060 2070 2080 2090 2100 >>gi|116006951|ref|NP_443124.3| polycystin 1-like 2 isof (2459 aa) initn: 6405 init1: 6405 opt: 6413 Z-score: 7443.9 bits: 1390.2 E(): 0 Smith-Waterman score: 6413; 97.718% identity (98.444% similar) in 964 aa overlap (30-993:1057-2015) 10 20 30 40 50 KIAA18 NKHAEPPMGIKTHPHSDGEAGLPVVQEVWGLPRTLTFSSLPCHLCPHLVARIQPWSWQG ::: :. :. . . ::::::::: gi|116 ASSSQIATVLRLLRVMEHVQTTLLLGKLPGGLPAMLATPSISVY-----TNRIQPWSWQG 1030 1040 1050 1060 1070 1080 60 70 80 90 100 110 KIAA18 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV 1090 1100 1110 1120 1130 1140 120 130 140 150 160 170 KIAA18 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR 1150 1160 1170 1180 1190 1200 180 190 200 210 220 230 KIAA18 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES 1210 1220 1230 1240 1250 1260 240 250 260 270 280 290 KIAA18 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST 1270 1280 1290 1300 1310 1320 300 310 320 330 340 350 KIAA18 FLVMPNAIDVHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL :::: :::..:::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 FLVMSNAINIHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL 1330 1340 1350 1360 1370 1380 360 370 380 390 400 410 KIAA18 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA 1390 1400 1410 1420 1430 1440 420 430 440 450 460 470 KIAA18 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV 1450 1460 1470 1480 1490 1500 480 490 500 510 520 530 KIAA18 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL 1510 1520 1530 1540 1550 1560 540 550 560 570 580 590 KIAA18 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR 1570 1580 1590 1600 1610 1620 600 610 620 630 640 650 KIAA18 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS 1630 1640 1650 1660 1670 1680 660 670 680 690 700 710 KIAA18 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR 1690 1700 1710 1720 1730 1740 720 730 740 750 760 770 KIAA18 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFPQHHSHAQALRQLQTLKGGLGVQPGTWA :::::::::::::::::::::::::::::::: : ::::::::::::::::::::::::: gi|116 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFSQPHSHAQALRQLQTLKGGLGVQPGTWA 1750 1760 1770 1780 1790 1800 780 790 800 810 820 830 KIAA18 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV 1810 1820 1830 1840 1850 1860 840 850 860 870 880 890 KIAA18 SFVESVFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 SFVESMFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD 1870 1880 1890 1900 1910 1920 900 910 920 930 940 950 KIAA18 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|116 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ 1930 1940 1950 1960 1970 1980 960 970 980 990 KIAA18 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGKS :::::::::::::::::::::::::::::::::: gi|116 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGFITDGNSKLVGSAQIRQVRVQESSCP 1990 2000 2010 2020 2030 2040 gi|116 LAQQPQAYLNGCRAPYSLDAEDMADYGEGWNATTLSEWQYQSQDQRQGYPIWGKLTVYRG 2050 2060 2070 2080 2090 2100 >>gi|194208830|ref|XP_001916475.1| PREDICTED: similar to (2433 aa) initn: 5536 init1: 5477 opt: 5485 Z-score: 6364.9 bits: 1190.5 E(): 0 Smith-Waterman score: 5485; 82.988% identity (92.842% similar) in 964 aa overlap (30-993:1058-2016) 10 20 30 40 50 KIAA18 NKHAEPPMGIKTHPHSDGEAGLPVVQEVWGLPRTLTFSSLPCHLCPHLVARIQPWSWQG ::: :. :. . . :::::::.: gi|194 ANGIHVATVAQLLGAVERVQAALLLGRLPGGLPAMLATPSISVY-----TNRIQPWSWRG 1030 1040 1050 1060 1070 1080 60 70 80 90 100 110 KIAA18 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV ::.. ::.:.:: :::::::.: : :::::::..:::::::::::.::::::::::: . gi|194 SSVHTAAASSVTFTLPAASSLGSTEDGQEPVDIRMMSFPKSPFPARGHFDVSGTVGGLSL 1090 1100 1110 1120 1130 1140 120 130 140 150 160 170 KIAA18 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR :::::::: :::::::::::::: :. ::.:::::::::::.:::.:::.:.:::::::: gi|194 TSPSGQLIAVKNLSENIEILLPRLSEGHSEPTVLNLTSPEAVWVNLTSGRAALGIQLHWR 1150 1160 1170 1180 1190 1200 180 190 200 210 220 230 KIAA18 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES ::: :::::::::::::.::::.::: : .::::: ::::.:.::.::::.:::::.::: gi|194 PDIPLTLSLGYGYHPNKTSYDAKTHLPPNAAPDELCTWILNPEDLHFGEGIYYLTVIPES 1210 1220 1230 1240 1250 1260 240 250 260 270 280 290 KIAA18 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST ::::.::::.:::::::::::::::: : :::.:::::::.:.: ::::::::::::::. gi|194 DLEPTPGRDFTVGITTFLSHCVFWDEDQWTWDNSGCQVGPQTTPSQTHCLCNHLTFFGSA 1270 1280 1290 1300 1310 1320 300 310 320 330 340 350 KIAA18 FLVMPNAIDVHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL :::::::.::.:::::::::::::::::::::::::::::: :::::::::::::::::: gi|194 FLVMPNAVDVRQTAELFATFEDNPVVVTTVGCLCVVYVLVVSWARRKDAQDQAKVKVTVL 1330 1340 1350 1360 1370 1380 360 370 380 390 400 410 KIAA18 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA :::::::::::::::::::::::::::.::::::::.:: :::::.::: ::::::.::: gi|194 EDNDPFAQYHYLVTVYTGHRRGAATSSQVTVTLYGLEGESEPHHLSDPDIPVFERGGVDA 1390 1400 1410 1420 1430 1440 420 430 440 450 460 470 KIAA18 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV ::::::::::::::::::::::::.::::::::::.::.:::::::::::::::.::::: gi|194 FLLSTLFPLGELRSLRLWHDNSGDQPSWYVSRVLVHDLAMDRKWYFLCNSWLSIDVGDCV 1450 1460 1470 1480 1490 1500 480 490 500 510 520 530 KIAA18 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL :::::::::::::::::::::.::::::.:::::::::: :::.::::::::::::::: gi|194 LDKVFPVATEQDRKQFSHLFFVKTSAGFRDGHIWYSIFSCAARSNFTRVQRVSCCFSLLL 1510 1520 1530 1540 1550 1560 540 550 560 570 580 590 KIAA18 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR ::::::::::::::::.:::::::::::::::::::::::.:::::::::::::.::::: gi|194 CTMLTSIMFWGVPKDPSEQKMDLGKIEFTWQEVMIGLESSLLMFPINLLIVQIFRNTRPR 1570 1580 1590 1600 1610 1620 600 610 620 630 640 650 KIAA18 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS :.:: .:::: ::::.:.:::::.:::::::::::::. :.:::::.:::.:::: :::: gi|194 VTKEPDTGKWHRGSPSLAPSPQPVEDGLLTPEAVTKDTRRLVSSLFEALKLPSPASGWDS 1630 1640 1650 1660 1670 1680 660 670 680 690 700 710 KIAA18 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR .::::::.::::.:::. :::.::::: :.:.::::.:::::: ..:: ::: : .. gi|194 TNLMDINQLLALLEDVVCLQNTAGQVFWGESKQREDPLTLTLGSVQVKEIEQCPMPTVGA 1690 1700 1710 1720 1730 1740 720 730 740 750 760 770 KIAA18 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFPQHHSHAQALRQLQTLKGGLGVQPGTWA : :::::::::::::::::.:: : ::::.:::: .::: ::::::::: :: :::: gi|194 SDPWKDSAYRQCLYLQLEHLEQALLLVGPQGFPQGQSHAGALRQLQTLKRRLGGQPGTLP 1750 1760 1770 1780 1790 1800 780 790 800 810 820 830 KIAA18 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV ::..:. .:.::.::::::.:::::::::::::::::::::::.:::::::.::::::: gi|194 PARTSSPWASRPPRGLPWWCVLVGWLLVAATSGVAAFFTMLYGLRYGRASSLKWLISMAV 1810 1820 1830 1840 1850 1860 840 850 860 870 880 890 KIAA18 SFVESVFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD ::.::.::::::::::::::::::::::.:::. :::::: : : : ::::::::: .: gi|194 SFLESMFVTQPLKVLGFAAFFALVLKRVEDEEEPVAPLPGCLSGSGPSALFRARRNSRKD 1870 1880 1890 1900 1910 1920 900 910 920 930 940 950 KIAA18 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ ::::::.: :::::::::::::::::::::::::::::::::::::::::.:::.::::. gi|194 VYQPPLAADIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPNAYHFNRHLE 1930 1940 1950 1960 1970 1980 960 970 980 990 KIAA18 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGKS ::::::::.::::.::: :::::::::::.: : gi|194 HSFTRGFSAVLGFQEFFAWANTTLVSNLYSHHSGFITDGNSKLVGSAQIRQVRVREGSCP 1990 2000 2010 2020 2030 2040 gi|194 LAPQLQASLDGCRAPYSMDVEDLSDYGEGWNASALHNSNGFSQAWQYQSQSQRRGYPIWG 2050 2060 2070 2080 2090 2100 >>gi|73957284|ref|XP_546816.2| PREDICTED: similar to pol (2448 aa) initn: 5227 init1: 5227 opt: 5241 Z-score: 6081.1 bits: 1138.0 E(): 0 Smith-Waterman score: 5241; 79.876% identity (91.390% similar) in 964 aa overlap (30-993:1056-2014) 10 20 30 40 50 KIAA18 NKHAEPPMGIKTHPHSDGEAGLPVVQEVWGLPRTLTFSSLPCHLCPHLVARIQPWSWQG ::: ::. :. . . :::: ::.: gi|739 AKGSQMASVPQLLRVVEHVQAALLLGTLPGGLPATLATPSISVY-----TNRIQPRSWRG 1030 1040 1050 1060 1070 1080 60 70 80 90 100 110 KIAA18 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV ::.. ::.:::: :::::::.:.: . :::::..:::::::::::::::::::.::. . gi|739 SSVHTKAASSATFTLPAASSLGSMEDSWEPVDIRVMSFPKSPFPARSHFDVSGTIGGFCL 1090 1100 1110 1120 1130 1140 120 130 140 150 160 170 KIAA18 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR :::::.:::..:::::::::::: . ::.:::::::::::::::.:: .:.:::::::: gi|739 TSPSGHLIPMRNLSENIEILLPRLLEGHSEPTVLNLTSPEALWVNLTSDRAALGIQLHWR 1150 1160 1170 1180 1190 1200 180 190 200 210 220 230 KIAA18 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES : : : :::::::::::.::::..:. ::.: : : ::::.:.::.:::::::::::::: gi|739 PAIPLILSLGYGYHPNKTSYDAKAHIPPMAATDGLSTWILNPEDLHFGEGVYYLTVVPES 1210 1220 1230 1240 1250 1260 240 250 260 270 280 290 KIAA18 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST ::: ::::::::::::::::::::::: :::.:::::::::. ::::::::::::::: gi|739 DLELIPGRDLTVGITTFLSHCVFWDEVQGTWDNSGCQVGPRTTLSQTHCLCNHLTFFGST 1270 1280 1290 1300 1310 1320 300 310 320 330 340 350 KIAA18 FLVMPNAIDVHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL ::::::.:::.::::::::::::::::::::::::.:.::::::.::::::::::.:::: gi|739 FLVMPNTIDVRQTAELFATFEDNPVVVTTVGCLCVAYILVVIWAKRKDAQDQAKVRVTVL 1330 1340 1350 1360 1370 1380 360 370 380 390 400 410 KIAA18 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA ::::::::::::.:::::::::::::::::::::::::: :::::.::: ::::::.::. gi|739 EDNDPFAQYHYLLTVYTGHRRGAATSSKVTVTLYGLDGESEPHHLSDPDIPVFERGGVDV 1390 1400 1410 1420 1430 1440 420 430 440 450 460 470 KIAA18 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV ::::::::::::.::::::::::::::::::::::.::. ::::.:::::::::.::::: gi|739 FLLSTLFPLGELKSLRLWHDNSGDRPSWYVSRVLVHDLARDRKWHFLCNSWLSIDVGDCV 1450 1460 1470 1480 1490 1500 480 490 500 510 520 530 KIAA18 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL :::::::::::::::::::::::::.::::::::::::: :::.::::::::::::::: gi|739 LDKVFPVATEQDRKQFSHLFFMKTSTGFQDGHIWYSIFSCSARSNFTRVQRVSCCFSLLL 1510 1520 1530 1540 1550 1560 540 550 560 570 580 590 KIAA18 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR ::::::::::::::::::::::::::::::::::::::::.:::::::::::::.::.:: gi|739 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSLLMFPINLLIVQIFRNTHPR 1570 1580 1590 1600 1610 1620 600 610 620 630 640 650 KIAA18 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS :.:::.::::::: ::. : ::::::::: :.::::. :.::.:::::::: :: :::: gi|739 VTKEQKTGKWDRGPLNLASSLQPMEDGLLTLEVVTKDMWRLVSNLFKALKVPPPASGWDS 1630 1640 1650 1660 1670 1680 660 670 680 690 700 710 KIAA18 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR ..: :::.::.:.:::: :: :: ::::::.::::. : ::: .:::. :: :... gi|739 ATLTDINQLLVLMEDVICLQNMEGQEFWEEAKQREDPLILPLGSLQMKERMQCLMPEVVP 1690 1700 1710 1720 1730 1740 720 730 740 750 760 770 KIAA18 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFPQHHSHAQALRQLQTLKGGLGVQPGTWA : ::.::.::::::::..::::.::::.:::: ..:..:: ::: ::: : : :: gi|739 SDSLKDNAYKQCLYLQLEYMEQELQLVGPHGFPQGQNHTRALSQLQMLKGRLRGQLGTPP 1750 1760 1770 1780 1790 1800 780 790 800 810 820 830 KIAA18 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV ::... ..::::.::::::.::::::::::::::::::::::::::::.::.::::.:. gi|739 PAYTGFRMASKPPRGLPWWCVLVGWLLVAATSGVAAFFTMLYGLHYGRAGSLKWLISVAI 1810 1820 1830 1840 1850 1860 840 850 860 870 880 890 KIAA18 SFVESVFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD :::::::.::::::::::::::::::::.:::. :: :::.: .::: ::::::: : .: gi|739 SFVESVFITQPLKVLGFAAFFALVLKRVEDEEEPVASLPGRLSSPDPTALFRARRCSRKD 1870 1880 1890 1900 1910 1920 900 910 920 930 940 950 KIAA18 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ .::::::. ::::::::::::::::.:::::::::::::::::::::::::.::.::::. gi|739 IYQPPLTTDIEKMKTTHLKEQKAFAFIREILAYLGFLWMLLLVAYGQRDPSTYHFNRHLE 1930 1940 1950 1960 1970 1980 960 970 980 990 KIAA18 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGKS ::::.:::.::.:.::: :::::::::::.: :: gi|739 HSFTQGFSAVLSFKEFFMWANTTLVSNLYSHYPGFITDGNSKLVGSAQIRQVRVRENSCP 1990 2000 2010 2020 2030 2040 gi|739 LVPHLQASLDRCHAPYSLDIEDLSDYGEGWNASILNNSRGFSQAWQYQNQRQRRGYPIWG 2050 2060 2070 2080 2090 2100 >>gi|81865247|sp|Q7TN88.1|PK1L2_MOUSE RecName: Full=Poly (2461 aa) initn: 4967 init1: 2716 opt: 4975 Z-score: 5771.8 bits: 1080.8 E(): 0 Smith-Waterman score: 4975; 76.349% identity (88.797% similar) in 964 aa overlap (30-993:1059-2011) 10 20 30 40 50 KIAA18 NKHAEPPMGIKTHPHSDGEAGLPVVQEVWGLPRTLTFSSLPCHLCPHLVARIQPWSWQG ::: :. :. . . :::: :::: gi|818 NSSQVAYIVAQLLRVIDHFQSALLLGTLPGGLPAILVTPSISVY-----TDRIQPRSWQG 1030 1040 1050 1060 1070 1080 60 70 80 90 100 110 KIAA18 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV ::.. ::::.:: ::::. : .: .::::::..::: ..:::.::.:::::::::::. gi|818 SSVHTAAADSVTFTLPAATFLCPMEDSQEPVDIRMMSFSQNPFPSRSQFDVSGTVGGLRL 1090 1100 1110 1120 1130 1140 120 130 140 150 160 170 KIAA18 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR :: ::. :::::::.:::::::: : : .: .:.:.: ::: ::::.:...::::::: gi|818 TSSSGHPIPVKNLSQNIEILLPRISA-HIEPKMLSLASREALSVNVTAGDTALGIQLHWG 1150 1160 1170 1180 1190 1200 180 190 200 210 220 230 KIAA18 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES : . : ::::::::::..:::::::: :..: .:::::: :.:: :::::::: ::::. gi|818 PGVPLILSLGYGYHPNETSYDAQTHLPPVAATGDLPTWILHPEDLPFGEGVYYLRVVPEA 1210 1220 1230 1240 1250 1260 240 250 260 270 280 290 KIAA18 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST ::: . ::.:::::::::.:::::::.:::::::::::::::.: ::::::::::::::. gi|818 DLESSSGRNLTVGITTFLAHCVFWDETQETWDDSGCQVGPRTTPSQTHCLCNHLTFFGSS 1270 1280 1290 1300 1310 1320 300 310 320 330 340 350 KIAA18 FLVMPNAIDVHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL ::::::::::.:::::::::::::::::::::::..::::.::::::: ::::::::.:: gi|818 FLVMPNAIDVRQTAELFATFEDNPVVVTTVGCLCMLYVLVLIWARRKDIQDQAKVKVVVL 1330 1340 1350 1360 1370 1380 360 370 380 390 400 410 KIAA18 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA ::::::::::::::::::::::::::::::.:::: ::: :::::.:::. :::::.::. gi|818 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTLTLYGSDGESEPHHLSDPDAAVFERGGVDV 1390 1400 1410 1420 1430 1440 420 430 440 450 460 470 KIAA18 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV ::::::::::::.:::::::::::::::::::::::: :.:::::::::::::..::::: gi|818 FLLSTLFPLGELQSLRLWHDNSGDRPSWYVSRVLVYDSVVDRKWYFLCNSWLSVDVGDCV 1450 1460 1470 1480 1490 1500 480 490 500 510 520 530 KIAA18 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL ::::::::::::::::::::: :::.::::::::::.: .:::::::::::::::.:: gi|818 LDKVFPVATEQDRKQFSHLFFTKTSTGFQDGHIWYSVFCSATRSSFTRVQRVSCCFSMLL 1510 1520 1530 1540 1550 1560 540 550 560 570 580 590 KIAA18 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: gi|818 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFRNTRPR 1570 1580 1590 1600 1610 1620 600 610 620 630 640 650 KIAA18 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS . .. :. .: :::::: :: :.::::::. .. ..::::::::: :: :::: gi|818 LPMGKD-GRQKQGPPNLTPSAQPTEEGLLTPET---GIQSLISSLFKALKVQPPASGWDS 1630 1640 1650 1660 1670 660 670 680 690 700 710 KIAA18 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR .: .::: ::.:.::.: :..: : :::::: ::::.: : :: . ::.. :::. : gi|818 MNPVDINYLLTLMEDIICPESTEGPGFWEEAKGREDPITSTRGSVKPKENTWHPKPELAV 1680 1690 1700 1710 1720 1730 720 730 740 750 760 770 KIAA18 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFPQHHSHAQALRQLQTLKGGLGVQPGTWA : ::::.::.::::::::::.::.:.::.:: .:::::::::::..::: : :::: : gi|818 RGLWKDSVYRRCLYLQLEHVERELQLLGPQGFLHHHSHAQALRQLHVLKGHLWGQPGTPA 1740 1750 1760 1770 1780 1790 780 790 800 810 820 830 KIAA18 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV :. :. .::: :.::::::.::::::::.::::::::::::::::::.:::.::::::: gi|818 LAYPSTSRVSKSPRGLPWWCVLVGWLLVATTSGVAAFFTMLYGLHYGRVSSLKWLISMAV 1800 1810 1820 1830 1840 1850 840 850 860 870 880 890 KIAA18 SFVESVFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD :::::::.::::::::::::::::::: :::: :. .:::: .: : .:::.::.::. gi|818 SFVESVFITQPLKVLGFAAFFALVLKREDDEE-TLPLFPGHLSSPGPGVLFRSRRHSSER 1860 1870 1880 1890 1900 1910 900 910 920 930 940 950 KIAA18 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ .:::: :::::::::.:::::::::::::::::.:::::::::::::::.:::..:::. gi|818 AYQPPPMAAIEKMKTTRLKEQKAFALIREILAYLAFLWMLLLVAYGQRDPNAYHFHRHLE 1920 1930 1940 1950 1960 1970 960 970 980 990 KIAA18 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGKS .::..::: ::::: ::.:::::::.::::: :: gi|818 RSFSQGFSPVLGFRGFFEWANTTLVKNLYGHHPGFVTDGNSKLVGSAHIRQVRVRESSCA 1980 1990 2000 2010 2020 2030 gi|818 VAQQLQDSLDGCHGPYSLGIEDLVDYGEGWNASAYNNSNGFPQAWRYQSQSQRRGYPMWG 2040 2050 2060 2070 2080 2090 >>gi|213417890|ref|NP_083962.3| polycystin 1-like 2 [Mus (2461 aa) initn: 4967 init1: 2716 opt: 4975 Z-score: 5771.8 bits: 1080.8 E(): 0 Smith-Waterman score: 4975; 76.349% identity (88.797% similar) in 964 aa overlap (30-993:1059-2011) 10 20 30 40 50 KIAA18 NKHAEPPMGIKTHPHSDGEAGLPVVQEVWGLPRTLTFSSLPCHLCPHLVARIQPWSWQG ::: :. :. . . :::: :::: gi|213 NSSQVAYIVAQLLRVIDHFQSALLLGTLPGGLPAILVTPSISVY-----TDRIQPRSWQG 1030 1040 1050 1060 1070 1080 60 70 80 90 100 110 KIAA18 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV ::.. ::::.:: ::::. : .: .::::::..::: ..:::.::.:::::::::::. gi|213 SSVHTAAADSVTFTLPAATFLCPMEDSQEPVDIRMMSFSQNPFPSRSQFDVSGTVGGLRL 1090 1100 1110 1120 1130 1140 120 130 140 150 160 170 KIAA18 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR :: ::. :::::::.:::::::: : : .: .:.:.: ::: ::::.:...::::::: gi|213 TSSSGHPIPVKNLSQNIEILLPRISA-HIEPKMLSLASREALSVNVTAGDTALGIQLHWG 1150 1160 1170 1180 1190 1200 180 190 200 210 220 230 KIAA18 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES : . : ::::::::::..:::::::: :..: .:::::: :.:: :::::::: ::::. gi|213 PGVPLILSLGYGYHPNETSYDAQTHLPPVAATGDLPTWILHPEDLPFGEGVYYLRVVPEA 1210 1220 1230 1240 1250 1260 240 250 260 270 280 290 KIAA18 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST ::: . ::.:::::::::.:::::::.:::::::::::::::.: ::::::::::::::. gi|213 DLESSSGRNLTVGITTFLAHCVFWDETQETWDDSGCQVGPRTTPSQTHCLCNHLTFFGSS 1270 1280 1290 1300 1310 1320 300 310 320 330 340 350 KIAA18 FLVMPNAIDVHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL ::::::::::.:::::::::::::::::::::::..::::.::::::: ::::::::.:: gi|213 FLVMPNAIDVRQTAELFATFEDNPVVVTTVGCLCMLYVLVLIWARRKDIQDQAKVKVVVL 1330 1340 1350 1360 1370 1380 360 370 380 390 400 410 KIAA18 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA ::::::::::::::::::::::::::::::.:::: ::: :::::.:::. :::::.::. gi|213 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTLTLYGSDGESEPHHLSDPDAAVFERGGVDV 1390 1400 1410 1420 1430 1440 420 430 440 450 460 470 KIAA18 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV ::::::::::::.:::::::::::::::::::::::: :.:::::::::::::..::::: gi|213 FLLSTLFPLGELQSLRLWHDNSGDRPSWYVSRVLVYDSVVDRKWYFLCNSWLSVDVGDCV 1450 1460 1470 1480 1490 1500 480 490 500 510 520 530 KIAA18 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL ::::::::::::::::::::: :::.::::::::::.: .:::::::::::::::.:: gi|213 LDKVFPVATEQDRKQFSHLFFTKTSTGFQDGHIWYSVFCSATRSSFTRVQRVSCCFSMLL 1510 1520 1530 1540 1550 1560 540 550 560 570 580 590 KIAA18 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: gi|213 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFRNTRPR 1570 1580 1590 1600 1610 1620 600 610 620 630 640 650 KIAA18 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS . .. :. .: :::::: :: :.::::::. .. ..::::::::: :: :::: gi|213 LPMGKD-GRQKQGPPNLTPSAQPTEEGLLTPET---GIQSLISSLFKALKVQPPASGWDS 1630 1640 1650 1660 1670 660 670 680 690 700 710 KIAA18 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR .: .::: ::.:.::.: :..: : :::::: ::::.: : :: . ::.. :::. : gi|213 MNPVDINYLLTLMEDIICPESTEGPGFWEEAKGREDPITSTRGSVKPKENTWHPKPELAV 1680 1690 1700 1710 1720 1730 720 730 740 750 760 770 KIAA18 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFPQHHSHAQALRQLQTLKGGLGVQPGTWA : ::::.::.::::::::::.::.:.::.:: .:::::::::::..::: : :::: : gi|213 RGLWKDSVYRRCLYLQLEHVERELQLLGPQGFLHHHSHAQALRQLHVLKGHLWGQPGTPA 1740 1750 1760 1770 1780 1790 780 790 800 810 820 830 KIAA18 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV :. :. .::: :.::::::.::::::::.::::::::::::::::::.:::.::::::: gi|213 LAYPSTSRVSKSPRGLPWWCVLVGWLLVATTSGVAAFFTMLYGLHYGRVSSLKWLISMAV 1800 1810 1820 1830 1840 1850 840 850 860 870 880 890 KIAA18 SFVESVFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRD :::::::.::::::::::::::::::: :::: :. .:::: .: : .:::.::.::. gi|213 SFVESVFITQPLKVLGFAAFFALVLKREDDEE-TLPLFPGHLSSPGPGVLFRSRRHSSER 1860 1870 1880 1890 1900 1910 900 910 920 930 940 950 KIAA18 VYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ .:::: :::::::::.:::::::::::::::::.:::::::::::::::.:::..:::. gi|213 AYQPPPMAAIEKMKTTRLKEQKAFALIREILAYLAFLWMLLLVAYGQRDPNAYHFHRHLE 1920 1930 1940 1950 1960 1970 960 970 980 990 KIAA18 HSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGKS .::..::: ::::: ::.:::::::.::::: :: gi|213 RSFSQGFSPVLGFRGFFEWANTTLVKNLYGHHPGFVTDGNSKLVGSAHIRQVRVRESSCA 1980 1990 2000 2010 2020 2030 gi|213 VAQQLQDSLDGCHGPYSLGIEDLVDYGEGWNASAYNNSNGFPQAWRYQSQSQRRGYPMWG 2040 2050 2060 2070 2080 2090 >>gi|114663813|ref|XP_511127.2| PREDICTED: polycystin 1- (1810 aa) initn: 4878 init1: 4878 opt: 4886 Z-score: 5670.1 bits: 1061.5 E(): 0 Smith-Waterman score: 4886; 95.346% identity (97.473% similar) in 752 aa overlap (30-781:1058-1804) 10 20 30 40 50 KIAA18 NKHAEPPMGIKTHPHSDGEAGLPVVQEVWGLPRTLTFSSLPCHLCPHLVARIQPWSWQG ::: :. :. . . ::::::::: gi|114 ASSSQFATVPQLLGVVEHVQTALLLGKLPGGLPAMLATPSISVY-----TNRIQPWSWQG 1030 1040 1050 1060 1070 1080 60 70 80 90 100 110 KIAA18 SSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRV :::: :::::::: :::::::.::::::::::::.::::::::::::::::::::::::: gi|114 SSLRTDAADSATFTLPAASSLGSLEGGQEPVDIKMMSFPKSPFPARSHFDVSGTVGGLRV 1090 1100 1110 1120 1130 1140 120 130 140 150 160 170 KIAA18 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWR 1150 1160 1170 1180 1190 1200 180 190 200 210 220 230 KIAA18 PDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|114 PDIALTLSLGYGYHPNKSSYDAQTRLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPES 1210 1220 1230 1240 1250 1260 240 250 260 270 280 290 KIAA18 DLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGST ::::::::::::::::::::::.:::::::::::::::::::: :::::::::::::::: gi|114 DLEPAPGRDLTVGITTFLSHCVLWDEVQETWDDSGCQVGPRTSLYQTHCLCNHLTFFGST 1270 1280 1290 1300 1310 1320 300 310 320 330 340 350 KIAA18 FLVMPNAIDVHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL :::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FLVMPNAIDIHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVL 1330 1340 1350 1360 1370 1380 360 370 380 390 400 410 KIAA18 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDA ::::::::::::::::::::::::::::::::::::::: :::::::::: ::::::::: gi|114 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGESEPHHLADPDTLVFERGAVDA 1390 1400 1410 1420 1430 1440 420 430 440 450 460 470 KIAA18 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCV ::::::::::::::::::::::::::::::::::::::.::::::::::::::.:::::: gi|114 FLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLAMDRKWYFLCNSWLSVNVGDCV 1450 1460 1470 1480 1490 1500 480 490 500 510 520 530 KIAA18 LDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LNKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLL 1510 1520 1530 1540 1550 1560 540 550 560 570 580 590 KIAA18 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: gi|114 CTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFRNTRPR 1570 1580 1590 1600 1610 1620 600 610 620 630 640 650 KIAA18 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VAKEKNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDS 1630 1640 1650 1660 1670 1680 660 670 680 690 700 710 KIAA18 VNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: gi|114 VNLMDINSLLALVEDVICPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAAR 1690 1700 1710 1720 1730 1740 720 730 740 750 760 770 KIAA18 SGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFPQHHSHAQALRQLQTLKGGLGVQPGTWA ::::::::::::::::::::::.::::::::::: ::::.:::::::::::::::::::: gi|114 SGPWKDSAYRQCLYLQLEHVEQKLRLVGPRGFPQPHSHARALRQLQTLKGGLGVQPGTWA 1750 1760 1770 1780 1790 1800 780 790 800 810 820 830 KIAA18 PAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAV :: gi|114 PAMPALFG 1810 >>gi|148679628|gb|EDL11575.1| mCG4315 [Mus musculus] (1198 aa) initn: 4836 init1: 2716 opt: 4837 Z-score: 5615.5 bits: 1050.8 E(): 0 Smith-Waterman score: 4837; 77.936% identity (90.231% similar) in 911 aa overlap (83-993:1-905) 60 70 80 90 100 110 KIAA18 QPWSWQGSSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSG .: .::::::..::: ..:::.::.::::: gi|148 MEDSQEPVDIRMMSFSQNPFPSRSQFDVSG 10 20 30 120 130 140 150 160 170 KIAA18 TVGGLRVTSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATL ::::::.:: ::. :::::::.:::::::: : : .: .:.:.: ::: ::::.:...: gi|148 TVGGLRLTSSSGHPIPVKNLSQNIEILLPRISA-HIEPKMLSLASREALSVNVTAGDTAL 40 50 60 70 80 180 190 200 210 220 230 KIAA18 GIQLHWRPDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYY :::::: : . : ::::::::::..:::::::: :..: .:::::: :.:: ::::::: gi|148 GIQLHWGPGVPLILSLGYGYHPNETSYDAQTHLPPVAATGDLPTWILHPEDLPFGEGVYY 90 100 110 120 130 140 240 250 260 270 280 290 KIAA18 LTVVPESDLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNH : ::::.::: . ::.:::::::::.:::::::.:::::::::::::::.: :::::::: gi|148 LRVVPEADLESSSGRNLTVGITTFLAHCVFWDETQETWDDSGCQVGPRTTPSQTHCLCNH 150 160 170 180 190 200 300 310 320 330 340 350 KIAA18 LTFFGSTFLVMPNAIDVHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQA ::::::.::::::::::.:::::::::::::::::::::::..::::.::::::: :::: gi|148 LTFFGSSFLVMPNAIDVRQTAELFATFEDNPVVVTTVGCLCMLYVLVLIWARRKDIQDQA 210 220 230 240 250 260 360 370 380 390 400 410 KIAA18 KVKVTVLEDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVF ::::.::::::::::::::::::::::::::::::::.:::: ::: :::::.:::. :: gi|148 KVKVVVLEDNDPFAQYHYLVTVYTGHRRGAATSSKVTLTLYGSDGESEPHHLSDPDAAVF 270 280 290 300 310 320 420 430 440 450 460 470 KIAA18 ERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLS :::.::.::::::::::::.:::::::::::::::::::::::: :.::::::::::::: gi|148 ERGGVDVFLLSTLFPLGELQSLRLWHDNSGDRPSWYVSRVLVYDSVVDRKWYFLCNSWLS 330 340 350 360 370 380 480 490 500 510 520 530 KIAA18 INVGDCVLDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVS ..:::::::::::::::::::::::::: :::.::::::::::.: .::::::::::: gi|148 VDVGDCVLDKVFPVATEQDRKQFSHLFFTKTSTGFQDGHIWYSVFCSATRSSFTRVQRVS 390 400 410 420 430 440 540 550 560 570 580 590 KIAA18 CCFSLLLCTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQI ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 CCFSMLLCTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQI 450 460 470 480 490 500 600 610 620 630 640 650 KIAA18 FQNTRPRVAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPS :.:::::. .. :. .: :::::: :: :.::::::. .. ..::::::::: gi|148 FRNTRPRLPMGKD-GRQKQGPPNLTPSAQPTEEGLLTPET---GIQSLISSLFKALKVQP 510 520 530 540 550 560 660 670 680 690 700 710 KIAA18 PALGWDSVNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQC :: ::::.: .::: ::.:.::.: :..: : :::::: ::::.: : :: . ::.. gi|148 PASGWDSMNPVDINYLLTLMEDIICPESTEGPGFWEEAKGREDPITSTRGSVKPKENTWH 570 580 590 600 610 620 720 730 740 750 760 770 KIAA18 PKPKAARSGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFPQHHSHAQALRQLQTLKGGLG :::. : : ::::.::.::::::::::.::.:.::.:: .:::::::::::..::: : gi|148 PKPELAVRGLWKDSVYRRCLYLQLEHVERELQLLGPQGFLHHHSHAQALRQLHVLKGHLW 630 640 650 660 670 680 780 790 800 810 820 830 KIAA18 VQPGTWAPAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLR :::: : :. :. .::: :.::::::.::::::::.::::::::::::::::::.:::. gi|148 GQPGTPALAYPSTSRVSKSPRGLPWWCVLVGWLLVATTSGVAAFFTMLYGLHYGRVSSLK 690 700 710 720 730 740 840 850 860 870 880 890 KIAA18 WLISMAVSFVESVFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRA ::::::::::::::.::::::::::::::::::: :::: :. .:::: .: : .:::. gi|148 WLISMAVSFVESVFITQPLKVLGFAAFFALVLKREDDEE-TLPLFPGHLSSPGPGVLFRS 750 760 770 780 790 800 900 910 920 930 940 950 KIAA18 RRNSSRDVYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAY ::.::. .:::: :::::::::.:::::::::::::::::.:::::::::::::::.:: gi|148 RRHSSERAYQPPPMAAIEKMKTTRLKEQKAFALIREILAYLAFLWMLLLVAYGQRDPNAY 810 820 830 840 850 860 960 970 980 990 KIAA18 HLNRHLQHSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGKS :..:::..::..::: ::::: ::.:::::::.::::: :: gi|148 HFHRHLERSFSQGFSPVLGFRGFFEWANTTLVKNLYGHHPGSPLTLRQRGRPPGFVTDGN 870 880 890 900 910 920 gi|148 SKLVGSAHIRQVRVRESSCAVAQQLQDSLDGCHGPYSLGIEDLVDYGEGWNASAYNNSNG 930 940 950 960 970 980 995 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Fri Mar 6 00:39:23 2009 done: Fri Mar 6 00:42:52 2009 Total Scan time: 1685.650 Total Display time: 0.990 Function used was FASTA [version 34.26.5 April 26, 2007]