# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/fj07836.fasta.nr -Q ../query/KIAA1864.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1864, 660 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7821219 sequences Expectation_n fit: rho(ln(x))= 5.4972+/-0.000192; mu= 11.3202+/- 0.011 mean_var=96.3553+/-18.441, 0's: 33 Z-trim: 57 B-trim: 64 in 2/65 Lambda= 0.130658 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|148679512|gb|EDL11459.1| mCG132588 [Mus musculu ( 610) 3060 587.5 4.5e-165 gi|149038178|gb|EDL92538.1| rCG51059 [Rattus norve ( 613) 3055 586.5 8.6e-165 gi|114663428|ref|XP_511085.2| PREDICTED: similar t (5333) 2776 534.8 2.8e-148 gi|145558935|sp|Q4G0P3.2|HYDIN_HUMAN RecName: Full (5120) 2772 534.1 4.5e-148 gi|194208781|ref|XP_001498384.2| PREDICTED: hydroc (5072) 2284 442.1 2.2e-120 gi|81865798|sp|Q80W93.1|HYDIN_MOUSE RecName: Full= (5099) 2173 421.1 4.4e-114 gi|46361984|ref|NP_766504.3| hydrocephalus inducin (5154) 2173 421.1 4.4e-114 gi|109508134|ref|XP_226468.4| PREDICTED: similar t (5110) 2153 417.4 6e-113 gi|109508886|ref|XP_001077360.1| PREDICTED: simila (5113) 2153 417.4 6e-113 gi|210130249|gb|EEA77921.1| hypothetical protein B (5229) 1551 303.9 8.8e-79 gi|118096191|ref|XP_425112.2| PREDICTED: similar t (5084) 1521 298.2 4.4e-77 gi|115649643|ref|XP_785443.2| PREDICTED: similar t (5457) 1508 295.8 2.5e-76 gi|210094901|gb|EEA43074.1| hypothetical protein B (5045) 1495 293.3 1.3e-75 gi|198419267|ref|XP_002122036.1| PREDICTED: simila (5198) 1456 286.0 2.2e-73 gi|190581581|gb|EDV21657.1| hypothetical protein T (5018) 1359 267.7 6.7e-68 gi|221127248|ref|XP_002159512.1| PREDICTED: simila (4513) 1290 254.7 5.1e-64 gi|94733112|emb|CAK04745.1| novel protein similar (1387) 1261 248.7 9.7e-63 gi|169210335|ref|XP_001718164.1| PREDICTED: simila ( 139) 973 193.5 4.1e-47 gi|163777053|gb|EDQ90671.1| predicted protein [Mon (4710) 770 156.6 1.7e-34 gi|158283985|gb|EDP09735.1| hydin-like protein [Ch (4524) 684 140.4 1.3e-29 gi|121915080|gb|EAY19872.1| hypothetical protein T (3202) 616 127.5 7.1e-26 gi|124393268|emb|CAK58797.1| unnamed protein produ (3759) 564 117.7 7.1e-23 gi|121904276|gb|EAY09227.1| hypothetical protein T (3198) 528 110.9 6.9e-21 gi|212512647|gb|EEB15378.1| conserved hypothetical (4772) 523 110.1 1.8e-20 gi|121904986|gb|EAY09922.1| hypothetical protein T (3024) 494 104.4 5.7e-19 gi|121888974|gb|EAX94421.1| hypothetical protein T (3013) 492 104.1 7.3e-19 gi|121898354|gb|EAY03447.1| hypothetical protein T (3049) 483 102.4 2.4e-18 gi|121884956|gb|EAX90636.1| hypothetical protein T (2981) 462 98.4 3.7e-17 gi|89290958|gb|EAR88946.1| hypothetical protein TT (4925) 464 99.0 4.1e-17 gi|121917345|gb|EAY22120.1| hypothetical protein T (2875) 447 95.6 2.5e-16 gi|121912858|gb|EAY17674.1| hypothetical protein T (2935) 426 91.6 4e-15 gi|121915109|gb|EAY19901.1| hypothetical protein T (2932) 416 89.7 1.5e-14 gi|91083419|ref|XP_968967.1| PREDICTED: similar to (6206) 415 89.8 2.9e-14 gi|121901569|gb|EAY06578.1| hypothetical protein T (3111) 411 88.8 3e-14 gi|124400996|emb|CAK66478.1| unnamed protein produ (2189) 406 87.7 4.4e-14 gi|121889990|gb|EAX95386.1| hypothetical protein T (3163) 402 87.1 9.7e-14 gi|221501386|gb|EEE27165.1| conserved hypothetical (3303) 356 78.5 4.1e-11 gi|221481933|gb|EEE20299.1| conserved hypothetical (4705) 357 78.8 4.6e-11 gi|211965500|gb|EEB00696.1| hypothetical protein T (4703) 356 78.6 5.3e-11 gi|62360606|gb|AAX81018.1| hypothetical protein, c (4521) 349 77.3 1.3e-10 gi|134060883|emb|CAM37900.1| hypothetical protein, (5553) 262 61.0 1.3e-05 gi|68127855|emb|CAJ06335.1| hypothetical protein, (5561) 262 61.0 1.3e-05 gi|134071391|emb|CAM70078.1| hypothetical protein, (5559) 256 59.8 2.8e-05 gi|70866525|gb|EAN82029.1| hypothetical protein, c (1600) 230 54.4 0.00034 gi|115669873|ref|XP_001202789.1| PREDICTED: simila (2754) 219 52.6 0.0021 gi|70884992|gb|EAN97829.1| hypothetical protein, c (4506) 221 53.1 0.0023 gi|189442218|gb|AAI67433.1| LOC553381 protein [Dan ( 911) 205 49.5 0.006 >>gi|148679512|gb|EDL11459.1| mCG132588 [Mus musculus] (610 aa) initn: 3129 init1: 2437 opt: 3060 Z-score: 3119.9 bits: 587.5 E(): 4.5e-165 Smith-Waterman score: 3060; 73.659% identity (88.293% similar) in 615 aa overlap (52-659:1-610) 30 40 50 60 70 80 KIAA18 AEGDMIITIILEMRKLECSTVPPLTKVDVKMETIERKISVREQTMSEKEELNKKKRNMGD ::.::::.::::. . :: ..::. : . gi|148 MESIERKVSVREH--ATLEETTRKKKAMTE 10 20 90 100 110 120 130 140 KIAA18 VSMHGLPLVQDQEDSEGDISKDPDKQLAQKFKTYELTLKDVQNILMYWDRKQGVQLPPAG . .:. :.:::::::. :: ::.:::::: :.. ::::::::::::::::...: .: gi|148 YPLL-IPISQEQEDSEGDFLKDSDKNLAQKFKIYDMCLKDVQNILMYWDRKQGMMVPHTG 30 40 50 60 70 80 150 160 170 180 190 KIAA18 MEEAPHEPDDQRQVPSGG--RRGRKDRERERLEKER-----LEREKAERERLEKLRALEE .: :: :::::.:::: :.:::::::::::::: ::::::::::::::.:::: gi|148 TDEMSHEADDQRQAPSGGGGRKGRKDRERERLEKERAEKERLEREKAERERLEKLKALEE 90 100 110 120 130 140 200 210 220 230 240 250 KIAA18 RSDWEGEGEEDHEEKKEKDLGVPFLNIQTPDFEGLSWKQALESDRLPKGEQAQEEQTSSS ::: ::::::.:: :: ::::::.:::.:::::.:::::::::.::::.:::::: : gi|148 RSDVEGEGEEEHEGKK--DLGVPFINIQSPDFEGVSWKQALESDKLPKGDQAQEEQPSPP 150 160 170 180 190 200 260 270 280 290 300 310 KIAA18 KGGKQKMKEKIDQVFESQKDKRHMALNRKVLSGEPAGTISQLSDTDLDNFNGQHSQEKFT ::.:::.:.: .:: :.::.::. .:: : : .:.: .:: : ..:.:.:::::: gi|148 KGSKQKLKDKPEQVRETQKEKRRTYSSRKGLPGGTSGSIVPMSDIDQNSFDGEHSQEKFI 210 220 230 240 250 260 320 330 340 350 360 370 KIAA18 RLNHFRWIVPANGEVTLQVHFSSDEFGNFDQTFNFEILGTCCQYQLYCRGICTYPYICQD :::::::::: ::::::.::::: . ::.:::::::.::: ::::::::.:::::::.: gi|148 RLNHFRWIVPPNGEVTLRVHFSSLDVGNYDQTFNFELLGTRRQYQLYCRGVCTYPYICRD 270 280 290 300 310 320 380 390 400 410 420 430 KIAA18 PKVVFPQRKMDMKTNEVIFKKYVMSTETYYFGPLLCGKSRDKYKSSLFPGNMETLTILNT ::::: ::: ::: .::. ::::.: : .:::::::::::::::::::::::::::::: gi|148 PKVVFSQRKKDMKLKEVVVKKYVVSMEKFYFGPLLCGKSRDKYKSSLFPGNMETLTILND 330 340 350 360 370 380 440 450 460 470 480 490 KIAA18 SLMVVEASFYFQNDVKANTYFLEPNTMVLKPNEKQILNVWAYPTSVGVFEDSIVCCINDN : ::::: : ::.:.::.:::::: .:.::::::: ::::::::.::.:::::::::..: gi|148 SPMVVEAYFCFQHDIKASTYFLEPVNMTLKPNEKQALNVWAYPTAVGIFEDSIVCCIKEN 390 400 410 420 430 440 500 510 520 530 540 550 KIAA18 PEPAIFQLSCQGIRPELELEPRQLHFDRLLLHRQESRVVLLRNVTLLPVAWRITSLEHLG ::::::.:::::::::.:.::::::::::::::.:...:.::::: :::::::..::::: gi|148 PEPAIFKLSCQGIRPEIEVEPRQLHFDRLLLHRKETKIVILRNVTPLPVAWRISNLEHLG 450 460 470 480 490 500 560 570 580 590 600 610 KIAA18 DDFTVSLMQGTIPPEAEYGLHLYFQPTKPVNIKKAIRLEVLDAENLLGVVQIENIMVFAE .:::::.::::. :..::::...:::.::::::::::.::::::::.::::::::..::: gi|148 EDFTVSMMQGTMLPKGEYGLQVHFQPSKPVNIKKAIRIEVLDAENLVGVVQIENILIFAE 510 520 530 540 550 560 620 630 640 650 660 KIAA18 AYDIALDITFPKGAEGGLDFGIVRVTEEAKQPLQLKNRGKYEIAFR .:::::::::::::::::::: .:: ::.:: ::::::::::: : gi|148 SYDIALDITFPKGAEGGLDFGTLRVMEEVKQTLQLKNRGKYEIIF 570 580 590 600 610 >>gi|149038178|gb|EDL92538.1| rCG51059 [Rattus norvegicu (613 aa) initn: 2594 init1: 2128 opt: 3055 Z-score: 3114.8 bits: 586.5 E(): 8.6e-165 Smith-Waterman score: 3055; 73.139% identity (88.997% similar) in 618 aa overlap (50-659:1-613) 20 30 40 50 60 70 KIAA18 TPAEGDMIITIILEMRKLECSTVPPLTKVDVKMETIERKISVREQTMSEKEELNKKKRNM .:::.::::.::::. . : : ..::. gi|149 MKMESIERKVSVREHGLLE--ETTRKKKAT 10 20 80 90 100 110 120 130 KIAA18 GDVSMHGLPLVQDQEDSEGDISKDPDKQLAQKFKTYELTLKDVQNILMYWDRKQGVQLPP . .. :.:..:.::.::::. :: ::.::::::.:. ::::::::::::::::...: gi|149 TEYAF-GFPITQEQEESEGDFLKDSDKNLAQKFKVYDTCLKDVQNILMYWDRKQGMMVPH 30 40 50 60 70 80 140 150 160 170 180 190 KIAA18 AGMEEAPHEPDDQRQVPSGG--RRGRKDRERERLEKER-----LEREKAERERLEKLRAL .: .: ::: :::::.:::: :.:::::::::::::: ::::::::::::::::. gi|149 TGPDEIPHEVDDQRQAPSGGGGRKGRKDRERERLEKERAEKERLEREKAERERLEKLRAM 90 100 110 120 130 140 200 210 220 230 240 250 KIAA18 EERSDWEGEGEEDHEEKKEKDLGVPFLNIQTPDFEGLSWKQALESDRLPKGEQAQEEQTS ::::: ::::::.:: :: ::::::.:::::::::.:::::::::.::::.:::::: : gi|149 EERSDGEGEGEEEHEGKK--DLGVPFINIQTPDFEGISWKQALESDKLPKGDQAQEEQPS 150 160 170 180 190 200 260 270 280 290 300 310 KIAA18 S-SKGGKQKMKEKIDQVFESQKDKRHMALNRKVLSGEPAGTISQLSDTDLDNFNGQHSQE .::.::: :.: .:. :.:::::. .:: ::: .:... .:: : .::.:.:::: gi|149 PPAKGSKQKSKDKTEQARETQKDKRRTYSGRKGLSGGASGNLAPMSDIDQNNFDGEHSQE 210 220 230 240 250 260 320 330 340 350 360 370 KIAA18 KFTRLNHFRWIVPANGEVTLQVHFSSDEFGNFDQTFNFEILGTCCQYQLYCRGICTYPYI :: :::::::::: ::::::..:::: . ::.:::::::.::: ::::::::.:::::: gi|149 KFIRLNHFRWIVPPNGEVTLRMHFSSFDVGNYDQTFNFELLGTRRQYQLYCRGVCTYPYI 270 280 290 300 310 320 380 390 400 410 420 430 KIAA18 CQDPKVVFPQRKMDMKTNEVIFKKYVMSTETYYFGPLLCGKSRDKYKSSLFPGNMETLTI :.:::.:.:::: ::: .::. ::::.: . .::::::::::::::::::.: ::::::: gi|149 CKDPKIVYPQRKKDMKLKEVVVKKYVVSMDKFYFGPLLCGKSRDKYKSSLYPDNMETLTI 330 340 350 360 370 380 440 450 460 470 480 490 KIAA18 LNTSLMVVEASFYFQNDVKANTYFLEPNTMVLKPNEKQILNVWAYPTSVGVFEDSIVCCI :: : ::::: : ::.::::.:::::: .:.::::::::::::::::.:::::::::::: gi|149 LNDSPMVVEAYFCFQHDVKASTYFLEPVNMTLKPNEKQILNVWAYPTAVGVFEDSIVCCI 390 400 410 420 430 440 500 510 520 530 540 550 KIAA18 NDNPEPAIFQLSCQGIRPELELEPRQLHFDRLLLHRQESRVVLLRNVTLLPVAWRITSLE ..:::::::.. :::::::.:.::::::::::::::.::. ..::::: :::::::.::: gi|149 KENPEPAIFKICCQGIRPEIEVEPRQLHFDRLLLHRKESKSLVLRNVTSLPVAWRISSLE 450 460 470 480 490 500 560 570 580 590 600 610 KIAA18 HLGDDFTVSLMQGTIPPEAEYGLHLYFQPTKPVNIKKAIRLEVLDAENLLGVVQIENIMV :::.:::::.::::. :..:.::...:::.::::::::::.::::::::.::::::::.. gi|149 HLGEDFTVSMMQGTMLPKGEFGLQVHFQPSKPVNIKKAIRIEVLDAENLVGVVQIENILI 510 520 530 540 550 560 620 630 640 650 660 KIAA18 FAEAYDIALDITFPKGAEGGLDFGIVRVTEEAKQPLQLKNRGKYEIAFR :::.::::::::::::.::::::: .:: ::.:::::::::::::: : gi|149 FAESYDIALDITFPKGTEGGLDFGTLRVLEEVKQPLQLKNRGKYEIIF 570 580 590 600 610 >>gi|114663428|ref|XP_511085.2| PREDICTED: similar to hy (5333 aa) initn: 3693 init1: 2771 opt: 2776 Z-score: 2818.4 bits: 534.8 E(): 2.8e-148 Smith-Waterman score: 3936; 86.827% identity (88.244% similar) in 706 aa overlap (34-659:2589-3294) 10 20 30 40 50 60 KIAA18 LGTVNRSHHHLSPVSTTPAEGDMIITIILEMRKLECST--VPPLTKVDVKMETIERKISV :.: . .. :::::::::::::::::::. gi|114 QQELERQKEEDELKRRVKKGKQGPIKEEPPMKKSQAANKQVPPLTKVDVKMETIERKISA 2560 2570 2580 2590 2600 2610 70 80 90 100 110 120 KIAA18 REQTMSEKEELNKKKRNMGDVSMHGLPLVQDQEDSEGDISKDPDKQLAQKFKTYELTLKD ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: gi|114 REQTMSEKEELNKKKRNMGDVSMHGLPLVQDQEDSEGDISKDPDKQLAQKFKAYELTLKD 2620 2630 2640 2650 2660 2670 130 140 150 160 170 KIAA18 VQNILMYWDRKQGVQLPPAGMEEAPHEPDDQRQVPSGGRRGRKDRERERLEKER-----L :::::::::::::::::::::::::::::::::::::::::::::::::::::: : gi|114 VQNILMYWDRKQGVQLPPAGMEEAPHEPDDQRQVPSGGRRGRKDRERERLEKERTEKERL 2680 2690 2700 2710 2720 2730 180 190 200 210 220 230 KIAA18 EREKAERERLEKLRALEERSDWEGEGEEDHEEKKEKDLGVPFLNIQTPDFEGLSWKQALE ::::::::::::::::::::::::::::::: ::::::::::::::::::::.::::::: gi|114 EREKAERERLEKLRALEERSDWEGEGEEDHEGKKEKDLGVPFLNIQTPDFEGMSWKQALE 2740 2750 2760 2770 2780 2790 240 KIAA18 SDRLPKGEQ--------------------------------------------------- ::.:::::: gi|114 SDKLPKGEQILDILGLGSSGPPIPPPALFSIVSYPVKRPPLTMTDDLEHFVFVIPPSEDI 2800 2810 2820 2830 2840 2850 250 260 270 280 KIAA18 ----------------------AQEEQTSSSKGGKQKMKEKIDQVFESQKDKRHMALNRK :::::::::::::::::::::::::.:::::::::::: gi|114 SLDEKKEMEIESDFLATTNTTKAQEEQTSSSKGGKQKMKEKIDQVFETQKDKRHMALNRK 2860 2870 2880 2890 2900 2910 290 300 310 320 330 340 KIAA18 VLSGEPAGTISQLSDTDLDNFNGQHSQEKFTRLNHFRWIVPANGEVTLQVHFSSDEFGNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VLSGEPAGTISQLSDTDLDNFNGQHSQEKFTRLNHFRWIVPANGEVTLQVHFSSDEFGNF 2920 2930 2940 2950 2960 2970 350 360 370 380 390 400 KIAA18 DQTFNFEILGTCCQYQLYCRGICTYPYICQDPKVVFPQRKMDMKTNEVIFKKYVMSTETY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DQTFNFEILGTCCQYQLYCRGICTYPYICQDPKVVFPQRKMDMKTNEVIFKKYVMSTETY 2980 2990 3000 3010 3020 3030 410 420 430 440 450 460 KIAA18 YFGPLLCGKSRDKYKSSLFPGNMETLTILNTSLMVVEASFYFQNDVKANTYFLEPNTMVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 YFGPLLCGKSRDKYKSSLFPGNMETLTILNTSLMVVEASFYFQNDVKANTYFLEPNTMVL 3040 3050 3060 3070 3080 3090 470 480 490 500 510 520 KIAA18 KPNEKQILNVWAYPTSVGVFEDSIVCCINDNPEPAIFQLSCQGIRPELELEPRQLHFDRL :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: gi|114 KPNEKQILNVWAYPTSVGVFEDSIVCCINDNPEPAIFQLSCQGVRPELELEPRQLHFDRL 3100 3110 3120 3130 3140 3150 530 540 550 560 570 580 KIAA18 LLHRQESRVVLLRNVTLLPVAWRITSLEHLGDDFTVSLMQGTIPPEAEYGLHLYFQPTKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LLHRQESRVVLLRNVTLLPVAWRITSLEHLGDDFTVSLMQGTIPPEAEYGLHLYFQPTKP 3160 3170 3180 3190 3200 3210 590 600 610 620 630 640 KIAA18 VNIKKAIRLEVLDAENLLGVVQIENIMVFAEAYDIALDITFPKGAEGGLDFGIVRVTEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VNIKKAIRLEVLDAENLLGVVQIENIMVFAEAYDIALDITFPKGAEGGLDFGIVRVTEEA 3220 3230 3240 3250 3260 3270 650 660 KIAA18 KQPLQLKNRGKYEIAFR :::::::::::::::: gi|114 KQPLQLKNRGKYEIAFSFSVDSVGISTPNINSMISVQPKKGTLTPTEKPTNVQVFFHAKK 3280 3290 3300 3310 3320 3330 >>gi|145558935|sp|Q4G0P3.2|HYDIN_HUMAN RecName: Full=Hyd (5120 aa) initn: 3675 init1: 2767 opt: 2772 Z-score: 2814.6 bits: 534.1 E(): 4.5e-148 Smith-Waterman score: 3915; 86.827% identity (87.677% similar) in 706 aa overlap (34-659:2376-3081) 10 20 30 40 50 60 KIAA18 LGTVNRSHHHLSPVSTTPAEGDMIITIILEMRKLECST--VPPLTKVDVKMETIERKISV :.: . .. :::::::::::::::::::: gi|145 QQELERQKEEDELKRRVKKGKQGPIKEEPPMKKSQAANKQVPPLTKVDVKMETIERKISV 2350 2360 2370 2380 2390 2400 70 80 90 100 110 120 KIAA18 REQTMSEKEELNKKKRNMGDVSMHGLPLVQDQEDSEGDISKDPDKQLAQKFKTYELTLKD :::::::::::::::::::::::::::::::::::::: ::::::::: ::::::::::: gi|145 REQTMSEKEELNKKKRNMGDVSMHGLPLVQDQEDSEGDNSKDPDKQLAPKFKTYELTLKD 2410 2420 2430 2440 2450 2460 130 140 150 160 170 KIAA18 VQNILMYWDRKQGVQLPPAGMEEAPHEPDDQRQVPSGGRRGRKDRERERLEKER-----L ::::::::::::::::::::::::::::::::::: :::::::::::::::::: : gi|145 VQNILMYWDRKQGVQLPPAGMEEAPHEPDDQRQVPLGGRRGRKDRERERLEKERTEKERL 2470 2480 2490 2500 2510 2520 180 190 200 210 220 230 KIAA18 EREKAERERLEKLRALEERSDWEGEGEEDHEEKKEKDLGVPFLNIQTPDFEGLSWKQALE ::::::::::::::::::::::::::::::: :::::::::::.:::::::::::::::: gi|145 EREKAERERLEKLRALEERSDWEGEGEEDHEGKKEKDLGVPFLDIQTPDFEGLSWKQALE 2530 2540 2550 2560 2570 2580 240 KIAA18 SDRLPKGEQ--------------------------------------------------- ::.:::::: gi|145 SDKLPKGEQILDILGLGASGPPIPPPALFSIVSYPVKRPPLTMTDDLEHFVFVIPPSEDI 2590 2600 2610 2620 2630 2640 250 260 270 280 KIAA18 ----------------------AQEEQTSSSKGGKQKMKEKIDQVFESQKDKRHMALNRK ::::::::::::::::::::::::: :::::::::::: gi|145 SLDEKKEMEIESDFLATTNTTKAQEEQTSSSKGGKQKMKEKIDQVFEIQKDKRHMALNRK 2650 2660 2670 2680 2690 2700 290 300 310 320 330 340 KIAA18 VLSGEPAGTISQLSDTDLDNFNGQHSQEKFTRLNHFRWIVPANGEVTLQVHFSSDEFGNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|145 VLSGEPAGTISQLSDTDLDNFNGQHSQEKFTRLNHFRWIVPANGEVTLQVHFSSDEFGNF 2710 2720 2730 2740 2750 2760 350 360 370 380 390 400 KIAA18 DQTFNFEILGTCCQYQLYCRGICTYPYICQDPKVVFPQRKMDMKTNEVIFKKYVMSTETY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|145 DQTFNFEILGTCCQYQLYCRGICTYPYICQDPKVVFPQRKMDMKTNEVIFKKYVMSTETY 2770 2780 2790 2800 2810 2820 410 420 430 440 450 460 KIAA18 YFGPLLCGKSRDKYKSSLFPGNMETLTILNTSLMVVEASFYFQNDVKANTYFLEPNTMVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|145 YFGPLLCGKSRDKYKSSLFPGNMETLTILNTSLMVVEASFYFQNDVKANTYFLEPNTMVL 2830 2840 2850 2860 2870 2880 470 480 490 500 510 520 KIAA18 KPNEKQILNVWAYPTSVGVFEDSIVCCINDNPEPAIFQLSCQGIRPELELEPRQLHFDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|145 KPNEKQILNVWAYPTSVGVFEDSIVCCINDNPEPAIFQLSCQGIRPELELEPRQLHFDRL 2890 2900 2910 2920 2930 2940 530 540 550 560 570 580 KIAA18 LLHRQESRVVLLRNVTLLPVAWRITSLEHLGDDFTVSLMQGTIPPEAEYGLHLYFQPTKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|145 LLHRQESRVVLLRNVTLLPVAWRITSLEHLGDDFTVSLMQGTIPPEAEYGLHLYFQPTKP 2950 2960 2970 2980 2990 3000 590 600 610 620 630 640 KIAA18 VNIKKAIRLEVLDAENLLGVVQIENIMVFAEAYDIALDITFPKGAEGGLDFGIVRVTEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|145 VNIKKAIRLEVLDAENLLGVVQIENIMVFAEAYDIALDITFPKGAEGGLDFGIVRVTEEA 3010 3020 3030 3040 3050 3060 650 660 KIAA18 KQPLQLKNRGKYEIAFR :::::::::::::::: gi|145 KQPLQLKNRGKYEIAFSFSVDSVGISTPNINSMISVQPKKGSLTPTEKPTNVQVFFHAKK 3070 3080 3090 3100 3110 3120 >>gi|194208781|ref|XP_001498384.2| PREDICTED: hydrocepha (5072 aa) initn: 3215 init1: 2263 opt: 2284 Z-score: 2317.5 bits: 442.1 E(): 2.2e-120 Smith-Waterman score: 3097; 68.714% identity (81.286% similar) in 700 aa overlap (42-659:2337-3033) 20 30 40 50 60 70 KIAA18 HHLSPVSTTPAEGDMIITIILEMRKLECSTVPPLTKVDVKMETIERKISVREQTMSEKEE .: ..:.:::::.::::.:::::.:.:::: gi|194 DELKRKIKKPKPGAVKEEPPLKKSQAANRQIPTFSKLDVKMEAIERKVSVREQAMTEKEE 2310 2320 2330 2340 2350 2360 80 90 100 110 120 130 KIAA18 LNKKKRN-MGDVSMHGLPLVQDQEDSEGDISKDPDKQLAQKFKTYELTLKDVQNILMYWD :..:..: .... . :.::...:::::.:. :: ::.::::::.:::::::.:::: ::: gi|194 LSRKRKNQLAEIPL-GFPLAHEQEDSEADLPKDTDKHLAQKFKVYELTLKDIQNILAYWD 2370 2380 2390 2400 2410 2420 140 150 160 170 180 KIAA18 RKQGVQLPPAGMEEAPHEPDDQRQVPSGGRRGRKDRERERLEKER-----LEREKAERER :.::. :: :: :. :::::::::.::::::::::::::: :::: :::::::::: gi|194 RNQGALLPQAGAEDMPHEPDDQRQLPSGGRRGRKDRERERAEKERAEKERLEREKAERER 2430 2440 2450 2460 2470 2480 190 200 210 220 230 240 KIAA18 LEKLRALEERSDWEGEGEEDHEEKKEKDLGVPFLNIQTPDFEGLSWKQALESDRLPKGEQ ::::::::: . ::::::::: : :::::::.::::::.:: .::::::::.::::.: gi|194 LEKLRALEESDGGEGEGEEDHEGK--KDLGVPFINIQTPDLEGSNWKQALESDKLPKGDQ 2490 2500 2510 2520 2530 2540 KIAA18 A----------------------------------------------------------- gi|194 ILDILGLGTSGPPIPPPTLFSIISYPMKRQPLATTEVLKHFLFVLTPSEELSLLEEKREL 2550 2560 2570 2580 2590 2600 250 260 270 280 KIAA18 -----------------QEEQTSSSKGGKQKMKEKIDQVFESQKDKRHMALNRKVLSGEP :::: .: .:..::.::: ::. :.:::::.:: ::: :: gi|194 EAEELSTAMGAVKVESEQEEQITSLQGSRQKVKEKTDQARETQKDKRRMAYNRKGLSEGT 2610 2620 2630 2640 2650 2660 290 300 310 320 330 340 KIAA18 AGTISQLSDTDLDNFNGQHSQEKFTRLNHFRWIVPANGEVTLQVHFSSDEFGNFDQTFNF .:: . :::.: ..:. ::::::: :::::::::::::::::.:::::...::::: ::: gi|194 SGTTAPLSDADQNDFSEQHSQEKFIRLNHFRWIVPANGEVTLRVHFSSNDLGNFDQMFNF 2670 2680 2690 2700 2710 2720 350 360 370 380 390 400 KIAA18 EILGTCCQYQLYCRGICTYPYICQDPKVVFPQRKMDMKTNEVIFKKYVMSTETYYFGPLL :::::: ::::::.:.:::::::::::::::::: ::::::::.:::.:: . .:::::: gi|194 EILGTCHQYQLYCQGVCTYPYICQDPKVVFPQRKKDMKTNEVILKKYIMSMDRFYFGPLL 2730 2740 2750 2760 2770 2780 410 420 430 440 450 460 KIAA18 CGKSRDKYKSSLFPGNMETLTILNTSLMVVEASFYFQNDVKANTYFLEPNTMVLKPNEKQ ::::::::::::::::::::::::.: ::::. : ::::.::.::::::..:.:::::.: gi|194 CGKSRDKYKSSLFPGNMETLTILNNSPMVVEVFFCFQNDIKASTYFLEPTSMTLKPNEEQ 2790 2800 2810 2820 2830 2840 470 480 490 500 510 520 KIAA18 ILNVWAYPTSVGVFEDSIVCCINDNPEPAIFQLSCQGIRPELELEPRQLHFDRLLLHRQE .:.::::::.::::::::::::.::::::::.:::::.::::::.:::::::::::::.: gi|194 MLSVWAYPTAVGVFEDSIVCCIKDNPEPAIFRLSCQGVRPELELDPRQLHFDRLLLHRRE 2850 2860 2870 2880 2890 2900 530 540 550 560 570 580 KIAA18 SRVVLLRNVTLLPVAWRITSLEHLGDDFTVSLMQGTIPPEAEYGLHLYFQPTKPVNIKKA ::: ::::: ::::::::::::::::::::::::::: .:::.:..::::.:::::::: gi|194 FRVVHLRNVTPLPVAWRITSLEHLGDDFTVSLMQGTIPAKAEYSLKVYFQPSKPVNIKKA 2910 2920 2930 2940 2950 2960 590 600 610 620 630 640 KIAA18 IRLEVLDAENLLGVVQIENIMVFAEAYDIALDITFPKGAEGGLDFGIVRVTEEAKQPLQL ::::: ::.::.::::::::.::::.::::::::::::::::::::.:.: ::.:: ::: gi|194 IRLEVSDADNLVGVVQIENIVVFAESYDIALDITFPKGAEGGLDFGVVKVMEEVKQVLQL 2970 2980 2990 3000 3010 3020 650 660 KIAA18 KNRGKYEIAFR :::::::: : gi|194 KNRGKYEIMFSFSVDSLGTNLNSMISVQPPKGSLTTMDKPTSVQVFFHAKKEVKIEHQPI 3030 3040 3050 3060 3070 3080 >>gi|81865798|sp|Q80W93.1|HYDIN_MOUSE RecName: Full=Hydr (5099 aa) initn: 2887 init1: 2171 opt: 2173 Z-score: 2204.4 bits: 421.1 E(): 4.4e-114 Smith-Waterman score: 2922; 65.374% identity (79.023% similar) in 696 aa overlap (45-659:2375-3065) 20 30 40 50 60 70 KIAA18 SPVSTTPAEGDMIITIILEMRKLECSTVPPLTKVDVKMETIERKISVREQTMSEKEELNK ..:...:::.::::.::::. . :: .. gi|818 KVKRPKAGPAAKEEPPLKKAQGATNKQLAAVAKIELKMESIERKVSVREH--ATLEETTR 2350 2360 2370 2380 2390 2400 80 90 100 110 120 130 KIAA18 KKRNMGDVSMHGLPLVQDQEDSEGDISKDPDKQLAQKFKTYELTLKDVQNILMYWDRKQG ::. : . . .:. :.:::::::. :: ::.:::::: :.. :::::::::::::::: gi|818 KKKAMTEYPLL-IPISQEQEDSEGDFLKDSDKNLAQKFKIYDMCLKDVQNILMYWDRKQG 2410 2420 2430 2440 2450 2460 140 150 160 170 180 KIAA18 VQLPPAGMEEAPHEPDDQRQVPSGG--RRGRKDRERERLEKER-----LEREKAERERLE ...: .: .: :: :::::.:::: :.:::::::::::::: :::::::::::: gi|818 MMVPHTGTDEMSHEADDQRQAPSGGGGRKGRKDRERERLEKERAEKERLEREKAERERLE 2470 2480 2490 2500 2510 2520 190 200 210 220 230 240 KIAA18 KLRALEERSDWEGEGEEDHEEKKEKDLGVPFLNIQTPDFEGLSWKQALESDRLPKGEQ-- ::.::::::: ::::::.:: : :::::::.:::.:::::.:::::::::.::::.: gi|818 KLKALEERSDVEGEGEEEHEGK--KDLGVPFINIQSPDFEGVSWKQALESDKLPKGDQIL 2530 2540 2550 2560 2570 KIAA18 ------------------------------------------------------------ gi|818 DILGLGSSGPPIPPPVLFSIISYPAKRQSLVATEILKHFVFVIPPNDDIPLMDEKKDPEG 2580 2590 2600 2610 2620 2630 250 260 270 280 290 KIAA18 ------------AQEEQTSSSKGGKQKMKEKIDQVFESQKDKRHMALNRKVLSGEPAGTI ::::: : ::.:::.:.: .:: :.::.::. .:: : : .:.: gi|818 DSDIFLNTIITKAQEEQPSPPKGSKQKLKDKPEQVRETQKEKRRTYSSRKGLPGGTSGSI 2640 2650 2660 2670 2680 2690 300 310 320 330 340 350 KIAA18 SQLSDTDLDNFNGQHSQEKFTRLNHFRWIVPANGEVTLQVHFSSDEFGNFDQTFNFEILG .:: : ..:.:.:::::: :::::::::: ::::::.::::: . ::.:::::::.:: gi|818 VPMSDIDQNSFDGEHSQEKFIRLNHFRWIVPPNGEVTLRVHFSSLDVGNYDQTFNFELLG 2700 2710 2720 2730 2740 2750 360 370 380 390 400 410 KIAA18 TCCQYQLYCRGICTYPYICQDPKVVFPQRKMDMKTNEVIFKKYVMSTETYYFGPLLCGKS : ::::::::.:::::::.:::::: ::: ::: .::. ::::.: : .:::::::::: gi|818 TRRQYQLYCRGVCTYPYICRDPKVVFSQRKKDMKLKEVVVKKYVVSMEKFYFGPLLCGKS 2760 2770 2780 2790 2800 2810 420 430 440 450 460 470 KIAA18 RDKYKSSLFPGNMETLTILNTSLMVVEASFYFQNDVKANTYFLEPNTMVLKPNEKQILNV :::::::::::::::::::: : ::::: : ::.:.::.:::::: .:.::::::: ::: gi|818 RDKYKSSLFPGNMETLTILNDSPMVVEAYFCFQHDIKASTYFLEPVNMTLKPNEKQALNV 2820 2830 2840 2850 2860 2870 480 490 500 510 520 530 KIAA18 WAYPTSVGVFEDSIVCCINDNPEPAIFQLSCQGIRPELELEPRQLHFDRLLLHRQESRVV :::::.::.:::::::::..:::::::.:::::::::.:.::::::::::::::.:...: gi|818 WAYPTAVGIFEDSIVCCIKENPEPAIFKLSCQGIRPEIEVEPRQLHFDRLLLHRKETKIV 2880 2890 2900 2910 2920 2930 540 550 560 570 580 590 KIAA18 LLRNVTLLPVAWRITSLEHLGDDFTVSLMQGTIPPEAEYGLHLYFQPTKPVNIKKAIRLE .::::: :::::::..:::::.:::::.::::. :..::::...:::.::::::::::.: gi|818 ILRNVTPLPVAWRISNLEHLGEDFTVSMMQGTMLPKGEYGLQVHFQPSKPVNIKKAIRIE 2940 2950 2960 2970 2980 2990 600 610 620 630 640 650 KIAA18 VLDAENLLGVVQIENIMVFAEAYDIALDITFPKGAEGGLDFGIVRVTEEAKQPLQLKNRG :::::::.::::::::..:::.:::::::::::::::::::: .:: ::.:: ::::::: gi|818 VLDAENLVGVVQIENILIFAESYDIALDITFPKGAEGGLDFGTLRVMEEVKQTLQLKNRG 3000 3010 3020 3030 3040 3050 660 KIAA18 KYEIAFR :::: : gi|818 KYEIIFSFTVDTLGVLPTNLSSMISVQPKRGTLASIDKPTTVQVFFRARKEVKIDCQPIL 3060 3070 3080 3090 3100 3110 >>gi|46361984|ref|NP_766504.3| hydrocephalus inducing [M (5154 aa) initn: 2887 init1: 2171 opt: 2173 Z-score: 2204.3 bits: 421.1 E(): 4.4e-114 Smith-Waterman score: 2922; 65.374% identity (79.023% similar) in 696 aa overlap (45-659:2430-3120) 20 30 40 50 60 70 KIAA18 SPVSTTPAEGDMIITIILEMRKLECSTVPPLTKVDVKMETIERKISVREQTMSEKEELNK ..:...:::.::::.::::. . :: .. gi|463 KVKRPKAGPAAKEEPPLKKAQGATNKQLAAVAKIELKMESIERKVSVREH--ATLEETTR 2400 2410 2420 2430 2440 2450 80 90 100 110 120 130 KIAA18 KKRNMGDVSMHGLPLVQDQEDSEGDISKDPDKQLAQKFKTYELTLKDVQNILMYWDRKQG ::. : . . .:. :.:::::::. :: ::.:::::: :.. :::::::::::::::: gi|463 KKKAMTEYPLL-IPISQEQEDSEGDFLKDSDKNLAQKFKIYDMCLKDVQNILMYWDRKQG 2460 2470 2480 2490 2500 2510 140 150 160 170 180 KIAA18 VQLPPAGMEEAPHEPDDQRQVPSGG--RRGRKDRERERLEKER-----LEREKAERERLE ...: .: .: :: :::::.:::: :.:::::::::::::: :::::::::::: gi|463 MMVPHTGTDEMSHEADDQRQAPSGGGGRKGRKDRERERLEKERAEKERLEREKAERERLE 2520 2530 2540 2550 2560 2570 190 200 210 220 230 240 KIAA18 KLRALEERSDWEGEGEEDHEEKKEKDLGVPFLNIQTPDFEGLSWKQALESDRLPKGEQ-- ::.::::::: ::::::.:: : :::::::.:::.:::::.:::::::::.::::.: gi|463 KLKALEERSDVEGEGEEEHEGK--KDLGVPFINIQSPDFEGVSWKQALESDKLPKGDQIL 2580 2590 2600 2610 2620 2630 KIAA18 ------------------------------------------------------------ gi|463 DILGLGSSGPPIPPPVLFSIISYPAKRQSLVATEILKHFVFVIPPNDDIPLMDEKKDPEG 2640 2650 2660 2670 2680 2690 250 260 270 280 290 KIAA18 ------------AQEEQTSSSKGGKQKMKEKIDQVFESQKDKRHMALNRKVLSGEPAGTI ::::: : ::.:::.:.: .:: :.::.::. .:: : : .:.: gi|463 DSDIFLNTIITKAQEEQPSPPKGSKQKLKDKPEQVRETQKEKRRTYSSRKGLPGGTSGSI 2700 2710 2720 2730 2740 2750 300 310 320 330 340 350 KIAA18 SQLSDTDLDNFNGQHSQEKFTRLNHFRWIVPANGEVTLQVHFSSDEFGNFDQTFNFEILG .:: : ..:.:.:::::: :::::::::: ::::::.::::: . ::.:::::::.:: gi|463 VPMSDIDQNSFDGEHSQEKFIRLNHFRWIVPPNGEVTLRVHFSSLDVGNYDQTFNFELLG 2760 2770 2780 2790 2800 2810 360 370 380 390 400 410 KIAA18 TCCQYQLYCRGICTYPYICQDPKVVFPQRKMDMKTNEVIFKKYVMSTETYYFGPLLCGKS : ::::::::.:::::::.:::::: ::: ::: .::. ::::.: : .:::::::::: gi|463 TRRQYQLYCRGVCTYPYICRDPKVVFSQRKKDMKLKEVVVKKYVVSMEKFYFGPLLCGKS 2820 2830 2840 2850 2860 2870 420 430 440 450 460 470 KIAA18 RDKYKSSLFPGNMETLTILNTSLMVVEASFYFQNDVKANTYFLEPNTMVLKPNEKQILNV :::::::::::::::::::: : ::::: : ::.:.::.:::::: .:.::::::: ::: gi|463 RDKYKSSLFPGNMETLTILNDSPMVVEAYFCFQHDIKASTYFLEPVNMTLKPNEKQALNV 2880 2890 2900 2910 2920 2930 480 490 500 510 520 530 KIAA18 WAYPTSVGVFEDSIVCCINDNPEPAIFQLSCQGIRPELELEPRQLHFDRLLLHRQESRVV :::::.::.:::::::::..:::::::.:::::::::.:.::::::::::::::.:...: gi|463 WAYPTAVGIFEDSIVCCIKENPEPAIFKLSCQGIRPEIEVEPRQLHFDRLLLHRKETKIV 2940 2950 2960 2970 2980 2990 540 550 560 570 580 590 KIAA18 LLRNVTLLPVAWRITSLEHLGDDFTVSLMQGTIPPEAEYGLHLYFQPTKPVNIKKAIRLE .::::: :::::::..:::::.:::::.::::. :..::::...:::.::::::::::.: gi|463 ILRNVTPLPVAWRISNLEHLGEDFTVSMMQGTMLPKGEYGLQVHFQPSKPVNIKKAIRIE 3000 3010 3020 3030 3040 3050 600 610 620 630 640 650 KIAA18 VLDAENLLGVVQIENIMVFAEAYDIALDITFPKGAEGGLDFGIVRVTEEAKQPLQLKNRG :::::::.::::::::..:::.:::::::::::::::::::: .:: ::.:: ::::::: gi|463 VLDAENLVGVVQIENILIFAESYDIALDITFPKGAEGGLDFGTLRVMEEVKQTLQLKNRG 3060 3070 3080 3090 3100 3110 660 KIAA18 KYEIAFR :::: : gi|463 KYEIIFSFTVDTLGVLPTNLSSMISVQPKRGTLASIDKPTTVQVFFRARKEVKIDCQPIL 3120 3130 3140 3150 3160 3170 >>gi|109508134|ref|XP_226468.4| PREDICTED: similar to hy (5110 aa) initn: 2614 init1: 2128 opt: 2153 Z-score: 2184.0 bits: 417.4 E(): 6e-113 Smith-Waterman score: 2917; 64.857% identity (79.571% similar) in 700 aa overlap (42-659:2396-3090) 20 30 40 50 60 70 KIAA18 HHLSPVSTTPAEGDMIITIILEMRKLECSTVPPLTKVDVKMETIERKISVREQTMSEKEE .: ..:...:::.::::.::::. . :: gi|109 LKRKVKRPKPGPVAKEEPPLKKSQGPTNKQLPSVAKLEMKMESIERKVSVREHGLL--EE 2370 2380 2390 2400 2410 2420 80 90 100 110 120 130 KIAA18 LNKKKRNMGDVSMHGLPLVQDQEDSEGDISKDPDKQLAQKFKTYELTLKDVQNILMYWDR ..::. . .. :.:..:.::.::::. :: ::.::::::.:. ::::::::::::: gi|109 TTRKKKATTEYAF-GFPITQEQEESEGDFLKDSDKNLAQKFKVYDTCLKDVQNILMYWDR 2430 2440 2450 2460 2470 2480 140 150 160 170 180 KIAA18 KQGVQLPPAGMEEAPHEPDDQRQVPSGG--RRGRKDRERERLEKER-----LEREKAERE :::...: .: .: ::: :::::.:::: :.:::::::::::::: ::::::::: gi|109 KQGMMVPHTGPDEIPHEVDDQRQAPSGGGGRKGRKDRERERLEKERAEKERLEREKAERE 2490 2500 2510 2520 2530 2540 190 200 210 220 230 240 KIAA18 RLEKLRALEERSDWEGEGEEDHEEKKEKDLGVPFLNIQTPDFEGLSWKQALESDRLPKGE :::::::.::::: ::::::.:: : :::::::.:::::::::.:::::::::.::::. gi|109 RLEKLRAMEERSDGEGEGEEEHEGK--KDLGVPFINIQTPDFEGISWKQALESDKLPKGD 2550 2560 2570 2580 2590 2600 KIAA18 Q----------------------------------------------------------- : gi|109 QILNILGLGSSGPPIPPPVLFSIISYPAKRQSLVATEILKHFVFVIPPNDDLPLSDEKKD 2610 2620 2630 2640 2650 2660 250 260 270 280 KIAA18 ---------------AQEEQTSS-SKGGKQKMKEKIDQVFESQKDKRHMALNRKVLSGEP ::::: : .::.::: :.: .:. :.:::::. .:: ::: gi|109 MEGDSDLFLNTIVTKAQEEQPSPPAKGSKQKSKDKTEQARETQKDKRRTYSGRKGLSGGA 2670 2680 2690 2700 2710 2720 290 300 310 320 330 340 KIAA18 AGTISQLSDTDLDNFNGQHSQEKFTRLNHFRWIVPANGEVTLQVHFSSDEFGNFDQTFNF .:... .:: : .::.:.:::::: :::::::::: ::::::..:::: . ::.:::::: gi|109 SGNLAPMSDIDQNNFDGEHSQEKFIRLNHFRWIVPPNGEVTLRMHFSSFDVGNYDQTFNF 2730 2740 2750 2760 2770 2780 350 360 370 380 390 400 KIAA18 EILGTCCQYQLYCRGICTYPYICQDPKVVFPQRKMDMKTNEVIFKKYVMSTETYYFGPLL :.::: ::::::::.:::::::.:::.:.:::: ::: .::. ::::.: . .:::::: gi|109 ELLGTRRQYQLYCRGVCTYPYICKDPKIVYPQRKKDMKLKEVVVKKYVVSMDKFYFGPLL 2790 2800 2810 2820 2830 2840 410 420 430 440 450 460 KIAA18 CGKSRDKYKSSLFPGNMETLTILNTSLMVVEASFYFQNDVKANTYFLEPNTMVLKPNEKQ ::::::::::::.: ::::::::: : ::::: : ::.::::.:::::: .:.::::::: gi|109 CGKSRDKYKSSLYPDNMETLTILNDSPMVVEAYFCFQHDVKASTYFLEPVNMTLKPNEKQ 2850 2860 2870 2880 2890 2900 470 480 490 500 510 520 KIAA18 ILNVWAYPTSVGVFEDSIVCCINDNPEPAIFQLSCQGIRPELELEPRQLHFDRLLLHRQE :::::::::.::::::::::::..:::::::.. :::::::.:.::::::::::::::.: gi|109 ILNVWAYPTAVGVFEDSIVCCIKENPEPAIFKICCQGIRPEIEVEPRQLHFDRLLLHRKE 2910 2920 2930 2940 2950 2960 530 540 550 560 570 580 KIAA18 SRVVLLRNVTLLPVAWRITSLEHLGDDFTVSLMQGTIPPEAEYGLHLYFQPTKPVNIKKA :. ..::::: :::::::.::::::.:::::.::::. :..:.::...:::.:::::::: gi|109 SKSLVLRNVTSLPVAWRISSLEHLGEDFTVSMMQGTMLPKGEFGLQVHFQPSKPVNIKKA 2970 2980 2990 3000 3010 3020 590 600 610 620 630 640 KIAA18 IRLEVLDAENLLGVVQIENIMVFAEAYDIALDITFPKGAEGGLDFGIVRVTEEAKQPLQL ::.::::::::.::::::::..:::.::::::::::::.::::::: .:: ::.:::::: gi|109 IRIEVLDAENLVGVVQIENILIFAESYDIALDITFPKGTEGGLDFGTLRVLEEVKQPLQL 3030 3040 3050 3060 3070 3080 650 660 KIAA18 KNRGKYEIAFR :::::::: : gi|109 KNRGKYEIIFSFTVDSVGILPTNLSSMIWIQPKRGTLASIDKPTTVQVFFRARKEVKVES 3090 3100 3110 3120 3130 3140 >>gi|109508886|ref|XP_001077360.1| PREDICTED: similar to (5113 aa) initn: 2614 init1: 2128 opt: 2153 Z-score: 2184.0 bits: 417.4 E(): 6e-113 Smith-Waterman score: 2917; 64.857% identity (79.571% similar) in 700 aa overlap (42-659:2394-3088) 20 30 40 50 60 70 KIAA18 HHLSPVSTTPAEGDMIITIILEMRKLECSTVPPLTKVDVKMETIERKISVREQTMSEKEE .: ..:...:::.::::.::::. . :: gi|109 LKRKVKRPKPGPVAKEEPPLKKSQGPTNKQLPSVAKLEMKMESIERKVSVREHGLL--EE 2370 2380 2390 2400 2410 2420 80 90 100 110 120 130 KIAA18 LNKKKRNMGDVSMHGLPLVQDQEDSEGDISKDPDKQLAQKFKTYELTLKDVQNILMYWDR ..::. . .. :.:..:.::.::::. :: ::.::::::.:. ::::::::::::: gi|109 TTRKKKATTEYAF-GFPITQEQEESEGDFLKDSDKNLAQKFKVYDTCLKDVQNILMYWDR 2430 2440 2450 2460 2470 2480 140 150 160 170 180 KIAA18 KQGVQLPPAGMEEAPHEPDDQRQVPSGG--RRGRKDRERERLEKER-----LEREKAERE :::...: .: .: ::: :::::.:::: :.:::::::::::::: ::::::::: gi|109 KQGMMVPHTGPDEIPHEVDDQRQAPSGGGGRKGRKDRERERLEKERAEKERLEREKAERE 2490 2500 2510 2520 2530 2540 190 200 210 220 230 240 KIAA18 RLEKLRALEERSDWEGEGEEDHEEKKEKDLGVPFLNIQTPDFEGLSWKQALESDRLPKGE :::::::.::::: ::::::.:: : :::::::.:::::::::.:::::::::.::::. gi|109 RLEKLRAMEERSDGEGEGEEEHEGK--KDLGVPFINIQTPDFEGISWKQALESDKLPKGD 2550 2560 2570 2580 2590 KIAA18 Q----------------------------------------------------------- : gi|109 QILNILGLGSSGPPIPPPVLFSIISYPAKRQSLVATEILKHFVFVIPPNDDLPLSDEKKD 2600 2610 2620 2630 2640 2650 250 260 270 280 KIAA18 ---------------AQEEQTSS-SKGGKQKMKEKIDQVFESQKDKRHMALNRKVLSGEP ::::: : .::.::: :.: .:. :.:::::. .:: ::: gi|109 MEGDSDLFLNTIVTKAQEEQPSPPAKGSKQKSKDKTEQARETQKDKRRTYSGRKGLSGGA 2660 2670 2680 2690 2700 2710 290 300 310 320 330 340 KIAA18 AGTISQLSDTDLDNFNGQHSQEKFTRLNHFRWIVPANGEVTLQVHFSSDEFGNFDQTFNF .:... .:: : .::.:.:::::: :::::::::: ::::::..:::: . ::.:::::: gi|109 SGNLAPMSDIDQNNFDGEHSQEKFIRLNHFRWIVPPNGEVTLRMHFSSFDVGNYDQTFNF 2720 2730 2740 2750 2760 2770 350 360 370 380 390 400 KIAA18 EILGTCCQYQLYCRGICTYPYICQDPKVVFPQRKMDMKTNEVIFKKYVMSTETYYFGPLL :.::: ::::::::.:::::::.:::.:.:::: ::: .::. ::::.: . .:::::: gi|109 ELLGTRRQYQLYCRGVCTYPYICKDPKIVYPQRKKDMKLKEVVVKKYVVSMDKFYFGPLL 2780 2790 2800 2810 2820 2830 410 420 430 440 450 460 KIAA18 CGKSRDKYKSSLFPGNMETLTILNTSLMVVEASFYFQNDVKANTYFLEPNTMVLKPNEKQ ::::::::::::.: ::::::::: : ::::: : ::.::::.:::::: .:.::::::: gi|109 CGKSRDKYKSSLYPDNMETLTILNDSPMVVEAYFCFQHDVKASTYFLEPVNMTLKPNEKQ 2840 2850 2860 2870 2880 2890 470 480 490 500 510 520 KIAA18 ILNVWAYPTSVGVFEDSIVCCINDNPEPAIFQLSCQGIRPELELEPRQLHFDRLLLHRQE :::::::::.::::::::::::..:::::::.. :::::::.:.::::::::::::::.: gi|109 ILNVWAYPTAVGVFEDSIVCCIKENPEPAIFKICCQGIRPEIEVEPRQLHFDRLLLHRKE 2900 2910 2920 2930 2940 2950 530 540 550 560 570 580 KIAA18 SRVVLLRNVTLLPVAWRITSLEHLGDDFTVSLMQGTIPPEAEYGLHLYFQPTKPVNIKKA :. ..::::: :::::::.::::::.:::::.::::. :..:.::...:::.:::::::: gi|109 SKSLVLRNVTSLPVAWRISSLEHLGEDFTVSMMQGTMLPKGEFGLQVHFQPSKPVNIKKA 2960 2970 2980 2990 3000 3010 590 600 610 620 630 640 KIAA18 IRLEVLDAENLLGVVQIENIMVFAEAYDIALDITFPKGAEGGLDFGIVRVTEEAKQPLQL ::.::::::::.::::::::..:::.::::::::::::.::::::: .:: ::.:::::: gi|109 IRIEVLDAENLVGVVQIENILIFAESYDIALDITFPKGTEGGLDFGTLRVLEEVKQPLQL 3020 3030 3040 3050 3060 3070 650 660 KIAA18 KNRGKYEIAFR :::::::: : gi|109 KNRGKYEIIFSFTVDSVGILPTNLSSMIWIQPKRGTLASIDKPTTVQVFFRARKEVKVES 3080 3090 3100 3110 3120 3130 >>gi|210130249|gb|EEA77921.1| hypothetical protein BRAFL (5229 aa) initn: 1658 init1: 1468 opt: 1551 Z-score: 1570.6 bits: 303.9 E(): 8.8e-79 Smith-Waterman score: 1698; 41.345% identity (68.097% similar) in 699 aa overlap (68-659:2481-3173) 40 50 60 70 80 90 KIAA18 ECSTVPPLTKVDVKMETIERKISVREQTMSEKEELNKKKRNMGDVSMHGLPLVQD--QED ::.: .:::.. .: :. : .. gi|210 VSSHGAGEHGAKGSPSAAGRPESHETDKSDEKDEGGKKKKGKDG---KGRPVSTDVTAKE 2460 2470 2480 2490 2500 100 110 120 130 140 KIAA18 SEGDISKDP-------DKQLAQKFKTYELTLKDVQNILMYWDRKQGVQLPPAGMEEAPHE : . ....: . ::...::.:: : :... :: .::: : . :. :: . gi|210 SSATVGEEPVPEPPPEEVQLSNRFKAYEHTQKEISPILEFWDRTQLIVHRPTTPEEEKES 2510 2520 2530 2540 2550 2560 150 160 170 180 190 200 KIAA18 PDDQRQVPSGGRRGR-KDRERERLEKERLEREKAERERLEKLR--ALEERSDWEGE---- ::: : ...::: ::.:.::::::. :.:. :.:.::.:. : :. :: gi|210 ADDQ--PPPSAKRGRAKDKEKERLEKEKQEKERLEKEKLERLKEGAGTPTSQLGGEPFPA 2570 2580 2590 2600 2610 2620 210 220 230 KIAA18 -GEEDHEEKKEKDLGVP--FLNIQTPD-------------------FEGLSW-------- ... ::. ...:::: .:. . :: ..::. gi|210 DSDKGGEEQAKEELGVPHIILDASDPDDPCGPRLLTSGQLPPVDEILDGLGLGPGGPPIP 2630 2640 2650 2660 2670 2680 240 KIAA18 -----------------------------------KQALESDRLP--------------- .. :::: gi|210 PPATFSVVPYPVKRKSPPGTDVASHYIFVAASQDDPNVAPEDRLPDVEPDTESVTPDKST 2690 2700 2710 2720 2730 2740 250 260 270 280 290 KIAA18 KGEQAQ---EEQTSSSKGGKQKMKEKIDQVFESQKDKRHMALN---RKVLSGE--PAGTI : :.:. ::.:..:. :..: ..: . . .: ::.:. : :. ::. : :. gi|210 KPEKASTGMEEHTATSSRGRSKERDKRSGT-DSVKDRRKSASRKGRRSSLSAPSPPPGAA 2750 2760 2770 2780 2790 2800 300 310 320 330 340 350 KIAA18 SQLSDTDLDNFNGQHS---QEKFTRLNHFRWIVPANGEVTLQVHFSSDEFGNFDQTFNFE . :..: .. :. : ..: .:. :::..::.:.:::...:.:...:.::::.::: gi|210 TPGSEADGQSTIGDTSTAIEHKSPKLSTFRWVIPAGGDVTLRLRFTSEDLGQFDQTLNFE 2810 2820 2830 2840 2850 2860 360 370 380 390 400 410 KIAA18 ILGTCCQYQLYCRGICTYPYICQDPKVVFPQRKMDMKTNEVIFKKYVMSTETYYFGPLLC :.:: .:::::::::..: : ..:.::::.:: . :..:.: ::::..:: . :::::: gi|210 IVGTRRRYQLYCRGICAFPTISREPRVVFPHRKKSKKSDEIIHKKYVLGTEIMEFGPLLC 2870 2880 2890 2900 2910 2920 420 430 440 450 460 470 KIAA18 GKSRDKYKSSLFPGNMETLTILNTSLMVVEASFYFQNDVKANTYFLEPNTMVLKPNEKQI ::.::.:: . .: ::: :::.::: . .. .: ::.:..:.::.:.: .:.:::.:.: gi|210 GKTRDRYKEGRYPENMEKLTIMNTSPLEADITFCFQQDAQATTYLLDPPSMLLKPTESQE 2930 2940 2950 2960 2970 2980 480 490 500 510 520 530 KIAA18 LNVWAYPTSVGVFEDSIVCCINDNPEPAIFQLSCQGIRPELELEPRQLHFDRLLLHRQES :..:::: . : ::: .:::. .::::..:..::.:..::.:.. .:: :...::::... gi|210 LTIWAYPKTPGYFEDCLVCCVRENPEPVVFRISCHGVKPEIEMDRKQLFFEKVLLHRKDT 2990 3000 3010 3020 3030 3040 540 550 560 570 580 590 KIAA18 RVVLLRNVTLLPVAWRITSLEHLGDDFTVSLMQGTIPPEAEYGLHLYFQPTKPVNIKKAI ... ::: :::::::::...:.:::::..: ::.: :..: .:: .:. ::.: :: : gi|210 KTIYLRNPTLLPVAWRISGVENLGDDFSLSAEQGVIDPKSELALHAHFRAMKPTNTKKII 3050 3060 3070 3080 3090 3100 600 610 620 630 640 650 KIAA18 RLEVLDAENLLGVVQIENIMVFAEAYDIALDITFPKGAEGGLDFGIVRVTEEAKQPLQLK :::: :..:..:.:..:::.: :::::.:::..:::::.::::::..:: .:.:: : :: gi|210 RLEVSDVDNIMGLVDVENIQVHAEAYDVALDMSFPKGADGGLDFGVIRVMDETKQTLTLK 3110 3120 3130 3140 3150 3160 660 KIAA18 NRGKYEIAFR :.:.:::.. gi|210 NKGRYEIGYEFMFETSDPNLPEVGSLFSVLPQHGSLLPTDRPTQVQVIFRSRYEVNIKDQ 3170 3180 3190 3200 3210 3220 660 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Thu Mar 5 23:38:52 2009 done: Thu Mar 5 23:42:32 2009 Total Scan time: 1517.210 Total Display time: 0.830 Function used was FASTA [version 34.26.5 April 26, 2007]