# /usr/local/bin/fasta34 -b50 -d10 -E0.01 -H -O./tmp/hg00622.fasta.huge -Q ../query/KIAA1818.ptfa ./tmplib.25089 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1818, 1157 aa vs ./tmplib.25089 library 1986348 residues in 2037 sequences Expectation_n fit: rho(ln(x))= 15.7316+/-0.0132; mu= -33.5368+/- 0.894 mean_var=889.9131+/-212.153, 0's: 0 Z-trim: 18 B-trim: 0 in 0/40 Lambda= 0.042993 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 39, opt: 27, open/ext: -10/-2, width: 16 The best scores are: opt bits E(2037) KIAA1819 ( 1173 res) hh00456 (1173) 374 39.6 0.0033 KIAA0192 ( 2124 res) ha02370 (2124) 378 40.1 0.0042 KIAA0181 ( 2079 res) ha02522s1 (2079) 362 39.1 0.0083 >>KIAA1819 ( 1173 res) hh00456 (1173 aa) initn: 1407 init1: 288 opt: 374 Z-score: 149.3 bits: 39.6 E(): 0.0033 Smith-Waterman score: 425; 23.362% identity (49.573% similar) in 702 aa overlap (474-1155:339-966) 450 460 470 480 490 KIAA18 QIYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPF-----QKNPKHASVLAES ::.. : : . : .: . .. .: KIAA18 FPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQS 310 320 330 340 350 360 500 510 520 530 540 550 KIAA18 GINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPPPL . .: :.. ...: .. . . . . :. : : . . ..: : . KIAA18 QRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPPS-AGPAFSMANSALSTSSPIPSV 370 380 390 400 410 420 560 570 580 590 600 610 KIAA18 PQPQAAGSQPPAGPPAVQPQPQPQPQTQPQPV-QAPAKAQPAITTGGSAAVLAGTIKTSV :: :: :: .: : . :. : .. : . : :. : : ... KIAA18 PQSQA---QPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSAL 430 440 450 460 470 480 620 630 640 650 660 670 KIAA18 TGTSMPTGAVSGNVIVNTIAGVPAATF-QSINKRLASPVAPGALTTPGGSAPAQVVHT-- ... :. . :. .:. .: :. . .::. :: . :::. ..:. . KIAA18 PSSAGPSPGPFGQ------EKIPSPSFGQQTFSPQSSPM-PG---VAGGSGQSKVMANYM 490 500 510 520 530 680 690 700 710 720 730 KIAA18 -QPPPRAVGSPATATPDLVSMATTQGV-RAVTSVTASAVVTTNLTPVQTPARSLVPQVSQ . : : :. :.. . : . :. . : . : : .. : :. KIAA18 YKAGPSAQGGHL----DVLMQQKPQDLSRSFINNPHPA-----MEPRQGNTKPLFHFNSD 540 550 560 570 580 740 750 760 770 780 KIAA18 ATGVQLPGKTIT---PAHFQLLRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTTTSQV .. :.:. . :. .. .::::::::::::::::::::::::::::::.. ..: KIAA18 QANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQ 590 600 610 620 630 640 790 800 810 820 830 840 KIAA18 QVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQKLQMPPQPPPPQAQSAPPQPTAQVQVQT : : : .. : : . . .. ..:.:. :. :: ::: : :: ... KIAA18 Q--QQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPL----LRS 650 660 670 680 690 850 860 870 880 890 900 KIAA18 SQPPQQQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQTQAPQPAQV : ::. . : : . ::.. : .: .. :: .:.: KIAA18 PLPLQQKLLLQQMQNQPIAG--------MGYQVSQQQR--QDQHSVVGQNTGPSPSP--- 700 710 720 730 740 910 920 930 940 950 960 KIAA18 ALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQ .: :.:.. . :: . ..: . ::. : ....: : :.: KIAA18 ---NP---------CSNPNTGSGYMNSQ--QSLLNQQLMGKKQTLQRQIMEQKQQLLLQQ 750 760 770 780 790 970 980 990 1000 1010 1020 KIAA18 QAVQQQKAIQPQAAQGPAAVQQKITAQQITTPGAQQKVAYAAQPALKTQFLTTPISQAQK : . . . : :: ...... ...:. ::. . . .. :: .. KIAA18 QMLADAEKIAPQDQ-----INRHLSRPPPDYKDQRRNVG-NMQPTAQYSGGSSTISLNSN 800 810 820 830 840 1030 1040 1050 1060 1070 1080 KIAA18 LAGAQQVQTQIQVAKLPQVVQQQTPVASIQQVASASQQASPQTVALTQATAAG---QQVQ : :. :.:. . :: .:. ... .... : .:.. ... .. .: . KIAA18 QALANPVSTHTIL----------TPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPN 850 860 870 880 890 1090 1100 1110 1120 1130 1140 KIAA18 MIPAVTATAQVVQQKLIQQQVVTTASAPLQTP---GAPNPAQVPASSDSPSQQPKLQMRV .... :..::. .: ... . . : : : .: :. . : . :.: KIAA18 TYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNV-ATFGAGSVGNSQQLR- 900 910 920 930 940 950 1150 KIAA18 PAVRLKTPTKPPCQ : . . . :: KIAA18 PNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPN 960 970 980 990 1000 1010 >>KIAA0192 ( 2124 res) ha02370 (2124 aa) initn: 1343 init1: 268 opt: 378 Z-score: 147.6 bits: 40.1 E(): 0.0042 Smith-Waterman score: 408; 27.531% identity (47.957% similar) in 563 aa overlap (374-874:1579-2122) 350 360 370 380 390 400 KIAA18 FAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVS- :. :.::: :: . : . :. .:.. KIAA01 SQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCE-PQGSLIDT 1550 1560 1570 1580 1590 1600 410 420 430 440 KIAA18 --DVVNSCSRIYRSSK-QCRNRYENVIIPRE--EGKSKNNRPL--------RTSQIYAQD . . . . :... : .. . : : . :: : . :: :... :. KIAA01 KGNKIAGFDSIFKKEGLQVSTKQK--ISPWDLFEGL-KPSAPLSWGWFGTVRVDRRVARG 1610 1620 1630 1640 1650 1660 450 460 470 480 490 500 KIAA18 ENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPI :. . :: .: . :. ..:: . : ...: ..: . : :: KIAA01 EEQQRLLLYHTH-----LRPRPRAYYLEPL-PLPPEDEEPPAPTLLEP---EKKAPEPPK 1670 1680 1690 1700 1710 510 520 530 540 550 KIAA18 QVASLRAERIAKEKKALADQ-QKAQQPAVAQPP----PPQPQP-----PPPPQQPPPPLP : ..:.: . . .: .:::. : . : :: . : : KIAA01 TDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGS 1720 1730 1740 1750 1760 1770 560 570 580 590 600 KIAA18 QPQAAGSQPPAG-PPAVQPQPQPQPQTQP-QPVQAPAKAQPA---------ITTGGSAAV . : : :: : :...: .::. : . :. : : .. KIAA01 ITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGL 1780 1790 1800 1810 1820 1830 610 620 630 640 650 660 KIAA18 LAGTIKTSVTGTSMPTGAVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTPGGSAP .. :::: ..:. . .:. . . . . :: ... .: . .: : : .: KIAA01 EPSSYKTSVYRQQQPA-VPQGQRLRQQLQQSQGMLGQSSVHQM-TPSSSYGLQTSQGYTP 1840 1850 1860 1870 1880 1890 670 680 690 700 710 KIAA18 --AQV---VHTQP-----PPRAVGSPATAT-----PDLVSMATTQGVRAVTSVTASA-VV ..: :: : :: ..: .: : ::. . : : .: . KIAA01 YVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTY 1900 1910 1920 1930 1940 1950 720 730 740 750 760 KIAA18 TTNLTPVQTPARSLV---PQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQQ .:: .: ... . :..: : .. : .: .:::::::::::::::: KIAA01 GHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQ 1960 1970 1980 1990 2000 2010 770 780 790 800 810 820 KIAA18 QQQQQQQQQQ-----QQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQKLQ :::::::::: ::: : : : : : :. : . . .: ..:.:. KIAA01 QQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQH--QQQQQQQA 2020 2030 2040 2050 2060 2070 830 840 850 860 870 880 KIAA18 MPPQPPP---PQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVANLQ :::: : :: : : : : : ::. .: . ::.. : :.:.. . : KIAA01 APPQPQPQSQPQFQRQGLQQTQQQQ-QTAALVRQLQQQLSN-TQPQPSTNIFGRY 2080 2090 2100 2110 2120 890 900 910 920 930 940 KIAA18 VARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISV >>KIAA0181 ( 2079 res) ha02522s1 (2079 aa) initn: 585 init1: 219 opt: 362 Z-score: 142.3 bits: 39.1 E(): 0.0083 Smith-Waterman score: 457; 27.273% identity (51.923% similar) in 572 aa overlap (623-1157:168-698) 600 610 620 630 640 650 KIAA18 PAKAQPAITTGGSAAVLAGTIKTSVTGTSMPTGAVSGNVIVNTIAGVPAATFQSINKRLA : :: :: : :: : :. .: :. KIAA01 LGILSVQIEGEGAINLALAQNRSQDVRMNGPMGA--GNS-VRMEAGFPMASGPGII-RMN 140 150 160 170 180 190 660 670 680 690 700 710 KIAA18 SPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATATPDLVSMATTQGVRAVTSVTASAVV .:.. .. :::.. .... : :. .: : : : : . .. KIAA01 NPAT--VMIPPGGNVSSSMMAPGPNPEL--QPRTPRPASQSDAMDPLLSGL--------- 200 210 220 230 240 720 730 740 750 760 770 KIAA18 TTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQQQQQ .. . :. ::.: :.. .. ..::.: :.:::::::::::::::::::: KIAA01 --HIQQQSHPSGSLAPPHHPMQPVSV-NRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQ 250 260 270 280 290 780 790 800 810 KIAA18 QQQQ------QQQQQQT--------TTTSQVQVP----QI-QGQAQSPAQIKAVGKLTPE :::: ::.::: :. .:: :: :. .: : : ..: .: . KIAA01 QQQQLQARPPQQHQQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTAN 300 310 320 330 340 350 820 830 840 850 860 KIAA18 HLIK-------MQKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAP . : :: :.:: :. :. : :: : . :.:: . . ::... KIAA01 QGWKKAPLPGPMQ-QQLQARPSLATVQTPSHPPPPYPFGSQQASQA-HTNFPQMSN---- 360 370 380 390 400 410 870 880 890 900 910 920 KIAA18 RPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSS :: . :. . .:: . .:::: : . .. : .:.. ..: .: :.. .. KIAA01 -PGQF-TAPQMKSLQGGP-SRVPTPLQQPHLTNKSPASSPSSFQQGSP--ASSPTVNQTQ 420 430 440 450 460 930 940 950 960 970 980 KIAA18 PGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHMQ-QLLKLKQQAVQQ-QKAIQPQAAQ . : . . .. :: .. :.. ..: .. ... ..:: .: ....: . KIAA01 QQMGPRPPQNNPLPQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGG 470 480 490 500 510 520 990 1000 1010 1020 1030 1040 KIAA18 GPAAVQQKITAQQITTPGAQQKV--AYAAQPALK--TQFLTTPISQAQKLAGAQQVQTQI : . ..: : . : .: . :. :. . :. .. : :: :.:. KIAA01 MPKRLPPGFSAGQANPNFMQGQVPSTTATTPGNSGAPQLQANQNVQHAGGQGAGPPQNQM 530 540 550 560 570 580 1050 1060 1070 1080 1090 1100 KIAA18 QVAKLPQVVQQQTPVASIQQVASASQQASPQTVALTQATAAGQQVQMIPAVTATAQVVQQ ::.. : ..: . . .:. . .: .. . .. .. :: : :. : KIAA01 QVSHGPPNMMQPS-LMGIHGNMNNQQAGTSGVPQVNLSNMQGQPQQGPPS--------QL 590 600 610 620 630 1110 1120 1130 1140 1150 KIAA18 KLIQQQVVTTASAPLQTPGAPNPAQVPASSDSPSQQPKLQMRV--PAVRL-KTPTK--PP ..::.: . . .: :. :: : : . . .:. :: : :. : .: . :: KIAA01 MGMHQQIVPSQGQMVQQQGTLNP-QNPMILSRAQLMPQGQMMVNPPSQNLGPSPQRMTPP 640 650 660 670 680 690 KIAA18 CQ : KIAA01 KQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKQQFNTQNQSNVMPGP 700 710 720 730 740 750 1157 residues in 1 query sequences 1986348 residues in 2037 library sequences Scomplib [34.26] start: Thu Dec 18 15:18:13 2008 done: Thu Dec 18 15:18:14 2008 Total Scan time: 0.750 Total Display time: 0.170 Function used was FASTA [version 34.26.5 April 26, 2007]