# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/fj21373.fasta.nr -Q ../query/KIAA1801.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1801, 1227 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7802034 sequences Expectation_n fit: rho(ln(x))= 6.0386+/-0.000207; mu= 10.3836+/- 0.011 mean_var=152.1168+/-28.460, 0's: 25 Z-trim: 141 B-trim: 4 in 1/65 Lambda= 0.103989 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 40, opt: 28, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|166232938|sp|Q96JM4.2|LRIQ1_HUMAN RecName: Full (1336) 8027 1217.6 0 gi|119617801|gb|EAW97395.1| leucine-rich repeats a (1537) 8022 1217.0 0 gi|120953300|ref|NP_001073379.1| leucine-rich repe (1722) 8022 1217.0 0 gi|119617802|gb|EAW97396.1| leucine-rich repeats a (1311) 7152 1086.4 0 gi|149261033|ref|XP_001478078.1| PREDICTED: eucine (1726) 4200 643.6 2.9e-181 gi|149261417|ref|XP_001478466.1| PREDICTED: simila (1726) 4194 642.7 5.5e-181 gi|194226625|ref|XP_001915618.1| PREDICTED: leucin (1676) 3779 580.5 3e-162 gi|194667002|ref|XP_001249913.2| PREDICTED: simila (1667) 3607 554.7 1.7e-154 gi|10433748|dbj|BAB14022.1| unnamed protein produc ( 534) 2710 419.5 2.7e-114 gi|148689728|gb|EDL21675.1| mCG15787 [Mus musculus ( 866) 2465 383.0 4.3e-103 gi|149067053|gb|EDM16786.1| similar to leucine-ric ( 867) 2412 375.0 1.1e-100 gi|123785953|sp|Q0P5X1.1|LRIQ1_MOUSE IQ domain-con ( 814) 2204 343.8 2.5e-91 gi|109480540|ref|XP_235088.4| PREDICTED: similar t (1575) 1756 276.9 6.5e-71 gi|74153162|dbj|BAE34547.1| unnamed protein produc ( 496) 1404 223.5 2.5e-55 gi|118082461|ref|XP_416125.2| PREDICTED: hypotheti ( 874) 906 149.1 1.1e-32 gi|12854115|dbj|BAB29931.1| unnamed protein produc ( 319) 890 146.2 3.1e-32 gi|62202512|gb|AAH93088.1| LRRIQ1 protein [Homo sa ( 294) 803 133.1 2.5e-28 gi|119617800|gb|EAW97394.1| leucine-rich repeats a ( 242) 768 127.7 8.4e-27 gi|148725258|emb|CAK04168.2| novel protein [Danio (1290) 753 126.3 1.1e-25 gi|94732447|emb|CAK11129.1| novel protein [Danio r ( 810) 721 121.3 2.4e-24 gi|115651993|ref|XP_001200118.1| PREDICTED: hypoth (1783) 693 117.5 7.2e-23 gi|156228362|gb|EDO49161.1| predicted protein [Nem ( 956) 615 105.5 1.6e-19 gi|210126900|gb|EEA74585.1| hypothetical protein B (5553) 598 103.9 2.9e-18 gi|210106273|gb|EEA54265.1| hypothetical protein B (1376) 586 101.3 4.1e-18 gi|121907959|gb|EAY12843.1| hypothetical protein T (1578) 481 85.6 2.5e-13 gi|190588832|gb|EDV28854.1| predicted protein [Tri (1590) 473 84.5 5.8e-13 gi|121885594|gb|EAX91231.1| trichohyalin, putative (1071) 446 80.2 7.5e-12 gi|169803020|gb|EAL51210.2| hypothetical protein, (1753) 433 78.5 3.9e-11 gi|110758177|ref|XP_392462.3| PREDICTED: similar t (3978) 426 77.9 1.4e-10 gi|121906600|gb|EAY11507.1| hypothetical protein T (2240) 420 76.7 1.8e-10 gi|121900670|gb|EAY05701.1| conserved hypothetical (1602) 414 75.6 2.7e-10 gi|47220564|emb|CAG05590.1| unnamed protein produc ( 213) 401 72.6 2.9e-10 gi|121892196|gb|EAX97497.1| virulent strain associ (1078) 409 74.6 3.5e-10 gi|121897529|gb|EAY02647.1| hypothetical protein T (1462) 405 74.2 6.4e-10 gi|194210794|ref|XP_001492721.2| PREDICTED: simila (1183) 403 73.8 6.9e-10 gi|124411220|emb|CAK76423.1| unnamed protein produ ( 672) 398 72.7 8.2e-10 gi|156555835|ref|XP_001602470.1| PREDICTED: simila (2871) 405 74.6 9.8e-10 gi|157017970|gb|EAA07771.4| AGAP002737-PA [Anophel (6668) 404 74.9 1.9e-09 gi|189516065|ref|XP_001346292.2| PREDICTED: wu:fc1 (1057) 391 71.9 2.3e-09 gi|194160170|gb|EDW75071.1| GK19899 [Drosophila wi (1914) 394 72.7 2.4e-09 gi|124410407|emb|CAK75649.1| unnamed protein produ ( 729) 385 70.8 3.3e-09 gi|89286901|gb|EAR84895.1| hypothetical protein TT (1878) 390 72.1 3.6e-09 gi|3044185|gb|AAC13303.1| mature parasite-infected (1661) 385 71.3 5.6e-09 gi|124400529|emb|CAK66015.1| unnamed protein produ ( 730) 380 70.1 5.6e-09 gi|109509437|ref|XP_001077753.1| PREDICTED: hypoth ( 532) 366 67.8 2e-08 gi|121888096|gb|EAX93587.1| variable membrane prot (2191) 374 69.8 2.1e-08 gi|165899546|gb|EDR26122.1| trichohyalin, putative (1229) 370 68.9 2.2e-08 gi|89304731|gb|EAS02719.1| TPR Domain containing p (2086) 373 69.6 2.2e-08 gi|124430075|emb|CAK94864.1| unnamed protein produ (2950) 375 70.1 2.3e-08 gi|22945532|gb|AAF51469.2| CG2839 [Drosophila mela ( 826) 367 68.2 2.3e-08 >>gi|166232938|sp|Q96JM4.2|LRIQ1_HUMAN RecName: Full=Leu (1336 aa) initn: 8027 init1: 8027 opt: 8027 Z-score: 6514.6 bits: 1217.6 E(): 0 Smith-Waterman score: 8027; 99.918% identity (100.000% similar) in 1219 aa overlap (9-1227:118-1336) 10 20 30 KIAA18 RTRFKDQQEKEEFMRSKTDCATPDFVPEPSPHDLPMDE :::::::::::::::::::::::::::::: gi|166 VSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDE 90 100 110 120 130 140 40 50 60 70 80 90 KIAA18 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR 150 160 170 180 190 200 100 110 120 130 140 150 KIAA18 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR 210 220 230 240 250 260 160 170 180 190 200 210 KIAA18 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 270 280 290 300 310 320 220 230 240 250 260 270 KIAA18 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR 330 340 350 360 370 380 280 290 300 310 320 330 KIAA18 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM 390 400 410 420 430 440 340 350 360 370 380 390 KIAA18 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD 450 460 470 480 490 500 400 410 420 430 440 450 KIAA18 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK 510 520 530 540 550 560 460 470 480 490 500 510 KIAA18 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVREN 570 580 590 600 610 620 520 530 540 550 560 570 KIAA18 VILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 VILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGL 630 640 650 660 670 680 580 590 600 610 620 630 KIAA18 SNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 SNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIK 690 700 710 720 730 740 640 650 660 670 680 690 KIAA18 SFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQDLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 SFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQDLP 750 760 770 780 790 800 700 710 720 730 740 750 KIAA18 GCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLCVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 GCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLCVVL 810 820 830 840 850 860 760 770 780 790 800 810 KIAA18 LNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNTGFCHHLGTSTSYLSL ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: gi|166 LNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNAGFCHHLGTSTSYLSL 870 880 890 900 910 920 820 830 840 850 860 870 KIAA18 AQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 AQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGL 930 940 950 960 970 980 880 890 900 910 920 930 KIAA18 CDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 CDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSI 990 1000 1010 1020 1030 1040 940 950 960 970 980 990 KIAA18 STVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 STVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACY 1050 1060 1070 1080 1090 1100 1000 1010 1020 1030 1040 1050 KIAA18 SLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFLALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 SLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFLALC 1110 1120 1130 1140 1150 1160 1060 1070 1080 1090 1100 1110 KIAA18 QSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITKKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 QSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITKKDE 1170 1180 1190 1200 1210 1220 1120 1130 1140 1150 1160 1170 KIAA18 SEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCENME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 SEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCENME 1230 1240 1250 1260 1270 1280 1180 1190 1200 1210 1220 KIAA18 GRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKM ::::::::::::::::::::::::::::::::::::::::::::::::: gi|166 GRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKM 1290 1300 1310 1320 1330 >>gi|119617801|gb|EAW97395.1| leucine-rich repeats and I (1537 aa) initn: 8314 init1: 8022 opt: 8022 Z-score: 6509.9 bits: 1217.0 E(): 0 Smith-Waterman score: 8022; 99.836% identity (100.000% similar) in 1219 aa overlap (9-1227:118-1336) 10 20 30 KIAA18 RTRFKDQQEKEEFMRSKTDCATPDFVPEPSPHDLPMDE :::::::::::::::::::::::::::::: gi|119 VSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDE 90 100 110 120 130 140 40 50 60 70 80 90 KIAA18 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR 150 160 170 180 190 200 100 110 120 130 140 150 KIAA18 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR 210 220 230 240 250 260 160 170 180 190 200 210 KIAA18 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 270 280 290 300 310 320 220 230 240 250 260 270 KIAA18 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR 330 340 350 360 370 380 280 290 300 310 320 330 KIAA18 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM 390 400 410 420 430 440 340 350 360 370 380 390 KIAA18 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD 450 460 470 480 490 500 400 410 420 430 440 450 KIAA18 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK 510 520 530 540 550 560 460 470 480 490 500 510 KIAA18 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVREN 570 580 590 600 610 620 520 530 540 550 560 570 KIAA18 VILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGL 630 640 650 660 670 680 580 590 600 610 620 630 KIAA18 SNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIK 690 700 710 720 730 740 640 650 660 670 680 690 KIAA18 SFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQDLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQDLP 750 760 770 780 790 800 700 710 720 730 740 750 KIAA18 GCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLCVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLCVVL 810 820 830 840 850 860 760 770 780 790 800 810 KIAA18 LNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNTGFCHHLGTSTSYLSL ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: gi|119 LNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNAGFCHHLGTSTSYLSL 870 880 890 900 910 920 820 830 840 850 860 870 KIAA18 AQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGL 930 940 950 960 970 980 880 890 900 910 920 930 KIAA18 CDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 CDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSI 990 1000 1010 1020 1030 1040 940 950 960 970 980 990 KIAA18 STVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 STVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACY 1050 1060 1070 1080 1090 1100 1000 1010 1020 1030 1040 1050 KIAA18 SLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFLALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFLALC 1110 1120 1130 1140 1150 1160 1060 1070 1080 1090 1100 1110 KIAA18 QSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITKKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITKKDE 1170 1180 1190 1200 1210 1220 1120 1130 1140 1150 1160 1170 KIAA18 SEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCENME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCENME 1230 1240 1250 1260 1270 1280 1180 1190 1200 1210 1220 KIAA18 GRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKM ::::::::::::::::::::::::::::::::::::::::::::::::. gi|119 GRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKIMAAVVIQSYWR 1290 1300 1310 1320 1330 1340 gi|119 GYLMRRQTHFSTRLHTAATEGLPNSSIKNQTILKKGKRENIVNIRKQREKAAILIQAVWK 1350 1360 1370 1380 1390 1400 >>gi|120953300|ref|NP_001073379.1| leucine-rich repeats (1722 aa) initn: 8314 init1: 8022 opt: 8022 Z-score: 6509.3 bits: 1217.0 E(): 0 Smith-Waterman score: 8022; 99.836% identity (100.000% similar) in 1219 aa overlap (9-1227:118-1336) 10 20 30 KIAA18 RTRFKDQQEKEEFMRSKTDCATPDFVPEPSPHDLPMDE :::::::::::::::::::::::::::::: gi|120 VSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDE 90 100 110 120 130 140 40 50 60 70 80 90 KIAA18 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR 150 160 170 180 190 200 100 110 120 130 140 150 KIAA18 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR 210 220 230 240 250 260 160 170 180 190 200 210 KIAA18 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 270 280 290 300 310 320 220 230 240 250 260 270 KIAA18 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR 330 340 350 360 370 380 280 290 300 310 320 330 KIAA18 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM 390 400 410 420 430 440 340 350 360 370 380 390 KIAA18 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD 450 460 470 480 490 500 400 410 420 430 440 450 KIAA18 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK 510 520 530 540 550 560 460 470 480 490 500 510 KIAA18 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVREN 570 580 590 600 610 620 520 530 540 550 560 570 KIAA18 VILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 VILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGL 630 640 650 660 670 680 580 590 600 610 620 630 KIAA18 SNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 SNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIK 690 700 710 720 730 740 640 650 660 670 680 690 KIAA18 SFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQDLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 SFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQDLP 750 760 770 780 790 800 700 710 720 730 740 750 KIAA18 GCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLCVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 GCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLCVVL 810 820 830 840 850 860 760 770 780 790 800 810 KIAA18 LNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNTGFCHHLGTSTSYLSL ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: gi|120 LNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNAGFCHHLGTSTSYLSL 870 880 890 900 910 920 820 830 840 850 860 870 KIAA18 AQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 AQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGL 930 940 950 960 970 980 880 890 900 910 920 930 KIAA18 CDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 CDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSI 990 1000 1010 1020 1030 1040 940 950 960 970 980 990 KIAA18 STVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 STVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACY 1050 1060 1070 1080 1090 1100 1000 1010 1020 1030 1040 1050 KIAA18 SLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFLALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 SLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFLALC 1110 1120 1130 1140 1150 1160 1060 1070 1080 1090 1100 1110 KIAA18 QSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITKKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 QSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITKKDE 1170 1180 1190 1200 1210 1220 1120 1130 1140 1150 1160 1170 KIAA18 SEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCENME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|120 SEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCENME 1230 1240 1250 1260 1270 1280 1180 1190 1200 1210 1220 KIAA18 GRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKM ::::::::::::::::::::::::::::::::::::::::::::::::. gi|120 GRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKIMAAVVIQSYWR 1290 1300 1310 1320 1330 1340 gi|120 GYLMRRQTHFSTRLHTAATEGLPNSSIKNQTILKKGKRENIVNIRKQREKAAILIQAVWK 1350 1360 1370 1380 1390 1400 >>gi|119617802|gb|EAW97396.1| leucine-rich repeats and I (1311 aa) initn: 7087 init1: 7087 opt: 7152 Z-score: 5805.2 bits: 1086.4 E(): 0 Smith-Waterman score: 7793; 97.867% identity (97.949% similar) in 1219 aa overlap (9-1227:118-1311) 10 20 30 KIAA18 RTRFKDQQEKEEFMRSKTDCATPDFVPEPSPHDLPMDE :::::::::::::::::::::::::::::: gi|119 VSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDE 90 100 110 120 130 140 40 50 60 70 80 90 KIAA18 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR 150 160 170 180 190 200 100 110 120 130 140 150 KIAA18 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR ::::::::::::::::::: :::::::::::::::: gi|119 HCWMKQFKVEKKKLENIQK-------------------------EYIRNLHLQMEEERTR 210 220 230 240 160 170 180 190 200 210 KIAA18 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 250 260 270 280 290 300 220 230 240 250 260 270 KIAA18 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR 310 320 330 340 350 360 280 290 300 310 320 330 KIAA18 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM 370 380 390 400 410 420 340 350 360 370 380 390 KIAA18 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD 430 440 450 460 470 480 400 410 420 430 440 450 KIAA18 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK 490 500 510 520 530 540 460 470 480 490 500 510 KIAA18 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVREN 550 560 570 580 590 600 520 530 540 550 560 570 KIAA18 VILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGL 610 620 630 640 650 660 580 590 600 610 620 630 KIAA18 SNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIK 670 680 690 700 710 720 640 650 660 670 680 690 KIAA18 SFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQDLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQDLP 730 740 750 760 770 780 700 710 720 730 740 750 KIAA18 GCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLCVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLCVVL 790 800 810 820 830 840 760 770 780 790 800 810 KIAA18 LNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNTGFCHHLGTSTSYLSL ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: gi|119 LNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNAGFCHHLGTSTSYLSL 850 860 870 880 890 900 820 830 840 850 860 870 KIAA18 AQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGL 910 920 930 940 950 960 880 890 900 910 920 930 KIAA18 CDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 CDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSI 970 980 990 1000 1010 1020 940 950 960 970 980 990 KIAA18 STVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 STVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACY 1030 1040 1050 1060 1070 1080 1000 1010 1020 1030 1040 1050 KIAA18 SLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFLALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFLALC 1090 1100 1110 1120 1130 1140 1060 1070 1080 1090 1100 1110 KIAA18 QSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITKKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITKKDE 1150 1160 1170 1180 1190 1200 1120 1130 1140 1150 1160 1170 KIAA18 SEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCENME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCENME 1210 1220 1230 1240 1250 1260 1180 1190 1200 1210 1220 KIAA18 GRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKM ::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKM 1270 1280 1290 1300 1310 >>gi|149261033|ref|XP_001478078.1| PREDICTED: eucine-ric (1726 aa) initn: 3804 init1: 2324 opt: 4200 Z-score: 3410.4 bits: 643.6 E(): 2.9e-181 Smith-Waterman score: 4233; 54.870% identity (79.058% similar) in 1232 aa overlap (9-1224:121-1337) 10 20 30 KIAA18 RTRFKDQQEKEEFMRSKTDCATPDFVPEPSPHDLPMDE :::::::: . : : : : :::: gi|149 VTDSHMHLRTGSLPESKANAEQLMKILSVIEKEEFMRSLAPSARCVSVREIITPDTPMDE 100 110 120 130 140 150 40 50 60 70 80 90 KIAA18 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR ..:::.::..::: ::::.::.::::::.::.:::.:.:.::.:: .::.. ::::.::: gi|149 YILPDEADLSFGYFEVEERCRKSFEAWQDKQQELEEKDKETLEAQNEREKRTFQEEDEKR 160 170 180 190 200 210 100 110 120 130 140 150 KIAA18 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR .:::.::.::::.::..:::.::::::::.:::::::::..::::.::::::.::::::: gi|149 QCWMRQFEVEKKHLEDLQKQDQDKMNDELHKEEKIWKEKYRQHEEHIRNLHLKMEEERTR 220 230 240 250 260 270 160 170 180 190 200 210 KIAA18 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK ... ::::: :.: . .::::::: :.: :.:.::.::::::.:.:.:.::: :::::: gi|149 LSELQEKEKARLFKLRYDAAVKIQATYRASVTYRKYSPIIKEQMEKKRRRAQELKEKEAK 280 290 300 310 320 330 220 230 240 250 260 270 KIAA18 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR :::::::.:.:::::::..::.::. :::.:::.::::::.:..::::. ::: : :: gi|149 IRQKEEEKRRRLEEEQRVEEEKKKKMLEERRRREREYEEKKSILRQEREEQRSKEVIRLR 340 350 360 370 380 390 280 290 300 310 320 330 KIAA18 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM : : . :::. ::::. ..:. .. . . :: :::. :: :::::::. :... : gi|149 EHAHSPLIITCALKKGDCHGKQQAIAHVPKGKGTIAKESVDSNSKKQEDAC--LAQQLNK 400 410 420 430 440 340 350 360 370 380 KIAA18 KENVD-RQTILKESIQVKLKESISSQTILADFKMEEKNE---------NLAKKRCSEELV .::. .: .:.: .::: . :.::...::.:::: ::.:..:::. gi|149 RENTHVQQLAMKKSTGIKLKPN---QAILVELKMNEKNESLPKLKINENLSKNQCSEQPS 450 460 470 480 490 500 390 400 410 420 430 440 KIAA18 KQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIIL :: . ::.:.:.:: ::.:: ...::.: : :.::.: ::.. .:: .:..::.:. .. gi|149 DQEFNAENVDQKNELENSNLKESVNEQYPWQGLESDTQTEEHV-EHVREEKVGQETEKLF 510 520 530 540 550 560 450 460 470 480 490 500 KIAA18 GHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSL-SL : :::.: ... : ....... ...: .:. .:.: .... ::. :.:: :: gi|149 GFNQEVSAEDSKQAQGVMEETREGLAEEIEIKEMTQQGGP-SDENNSSPISM-QKSLPSL 570 580 590 600 610 620 510 520 530 540 550 560 KIAA18 TSENSKDVRENVILQE-KEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQD : .: . :...: :.: .: ::..::: :.... . ...:. :. .. ::. . :: gi|149 TPDNPEPVERSVTLEEDQETDLKSERIEEIPEEGVLSCDAAVINA-DASVHTEGEADLQD 630 640 650 660 670 680 570 580 590 600 610 620 KIAA18 YVLGRHAPCEGLSNYNAESSMVSKEV-NSLKSEIRNISEKCHENAPEPDS-MTCCVSEST . :. :: : ....:.. ....:: .: ::::.. :: ... : :. .:: ::. : gi|149 SASGKLAPSEEAGSHSANNLLATEEVEDSPKSEIQEALEKGQQTKAEADGVLTCSVSQLT 690 700 710 720 730 740 630 640 650 660 670 680 KIAA18 LLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWD .: :.:::::::.:.:::: :::.:::.::::...: :::: : : :: ::. ::: gi|149 VLSSVEERRLAWVKTFKPWAEIFEQNQHKKIVKKRRLVKCPPNTMPPLDPSAILQYGPWK 750 760 770 780 790 800 690 700 710 720 730 740 KIAA18 TLQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIE .:.:: ..::: :::: :::::::.:::.:::::::::::..::.: .:::::::::::: gi|149 SLKQVPVITFQGLPGCSLSTLAECSNLQILSLRRCGLTSLQGLSHCTRLKYIDAQENHIE 810 820 830 840 850 860 750 760 770 780 790 800 KIAA18 AIECENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNTG :: ::::::: :::::.: :::.::.:::::.: ::::.::::::. .:::.. :. :.: gi|149 AISCENLENLSVVLLNNNLLTSIHGFDGCTNLQSLELSHNKITRINLDFFLKRFLIKNAG 870 880 890 900 910 920 810 820 830 840 850 860 KIAA18 FCHHLGTSTSYLSLAQVWIPTGLCWSWIP--ITSLTKNSDCNFLISHLYWNCGLESLKNL : : ..: : : . : : . : .: : :. :. . .. .:: :::::: : gi|149 HCSHTSNSKLILPLPKQWPPLDILWVTMPDIIYSIMYNT--HVILENLYIPGGLESLKYL 930 940 950 960 970 870 880 890 900 910 920 KIAA18 QQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSL :.: .::::::.:::::..:::::::::::::: ..:. :::::::.::::::: : ::: gi|149 QELTVDHNQLISTKGLCEAPTIVYLDCSHNHLTGIDGIGNCGLLQIIKLQGNYLREPPSL 980 990 1000 1010 1020 1030 930 940 950 960 970 980 KIAA18 ENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHN .: ::::::::::::::.::..:: :::::: ..::::::. ::::::.:::::::::.: gi|149 RNHVLLRELHLDDNSISSVEGLSSCWLPLLQYLSISQNSLATIVPLFHLVSLEKLDVSNN 1040 1050 1060 1070 1080 1090 990 1000 1010 1020 1030 1040 KIAA18 CLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESR ::::: ... ::.:::::.:: :::::.::: :::::.::.:::::.:::..::: ...: gi|149 CLSDLTNVMCWFNACYSLRELCLTGNPVLQEINWRDSILKTLPALRVLNGDMLNSYANDR 1100 1110 1120 1130 1140 1150 1050 1060 1070 1080 1090 1100 KIAA18 TEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEY ::: . .::::: :..::::: :.::: : :..:: ... : .:.: :: :: : gi|149 IEEHYHQDLRCLLALCQYQLQEFNLLPEKYITQKRDILTLHAVDRLSQYYKDLMKLSHEC 1160 1170 1180 1190 1200 1210 1110 1120 1130 1140 1150 1160 KIAA18 RHAHERGDVTITKKDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSV :.:::.:::. :... .:..::: .:.::.::: .... . : ::: . .:.: gi|149 RRAHEQGDVNTTERSAAETNKNHPDFSNTDSALQNKTLHAQTNSCEADSPATSPNPLDTV 1220 1230 1240 1250 1260 1270 1170 1180 1190 1200 1210 1220 KIAA18 SSHSPLSKSATCENMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIE : .. ::...::.:: :. .: :.:. :: . : : :. :..: . ::.: : gi|149 FRPS----TSHCEELRGRNQEKLMAHKSEQSRISSRSNSRASFIEMKMADSPMSNHHNAE 1280 1290 1300 1310 1320 1330 KIAA18 PSEKM : gi|149 RSSPTKAAMVIQAQWRSYIAHRQINCSAEMHPTTTEPLQDPLINNQTTSNEERRKTNMDI 1340 1350 1360 1370 1380 1390 >>gi|149261417|ref|XP_001478466.1| PREDICTED: similar to (1726 aa) initn: 3798 init1: 2318 opt: 4194 Z-score: 3405.6 bits: 642.7 E(): 5.5e-181 Smith-Waterman score: 4227; 54.789% identity (78.977% similar) in 1232 aa overlap (9-1224:121-1337) 10 20 30 KIAA18 RTRFKDQQEKEEFMRSKTDCATPDFVPEPSPHDLPMDE :::::::: . : : : : :::: gi|149 VTDSHMHLRTGSLPESKANAEQLMKILSVIEKEEFMRSLAPSARCVSVREIITPDTPMDE 100 110 120 130 140 150 40 50 60 70 80 90 KIAA18 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR ..:::.::..::: ::::.::.::::::.::.:::.:.:.::.:: .::.. ::::.::: gi|149 YILPDEADLSFGYFEVEERCRKSFEAWQDKQQELEEKDKETLEAQNEREKRTFQEEDEKR 160 170 180 190 200 210 100 110 120 130 140 150 KIAA18 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR .:::.::.::::.::..:::.::::::::.:::::::::..::::.::::::.::::::: gi|149 QCWMRQFEVEKKHLEDLQKQDQDKMNDELHKEEKIWKEKYRQHEEHIRNLHLKMEEERTR 220 230 240 250 260 270 160 170 180 190 200 210 KIAA18 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK ... ::::: :.: . .::::::: :.: :.:.::.::::::.:.:.:.::: :::::: gi|149 LSELQEKEKARLFKLRYDAAVKIQATYRASVTYRKYSPIIKEQMEKKRRRAQELKEKEAK 280 290 300 310 320 330 220 230 240 250 260 270 KIAA18 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR :::::::.:.:::::::..::.::. :::.:::.::::::.:..::::. ::: : :: gi|149 IRQKEEEKRRRLEEEQRVEEEKKKKMLEERRRREREYEEKKSILRQEREEQRSKEVIRLR 340 350 360 370 380 390 280 290 300 310 320 330 KIAA18 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM : : . :::. ::::. ..:. .. . . :: :::. :: :::::::. :... : gi|149 EHAHSPLIITCALKKGDCHGKQQAIAHVPKGKGTIAKESVDSNSKKQEDAC--LAQQLNK 400 410 420 430 440 340 350 360 370 380 KIAA18 KENVD-RQTILKESIQVKLKESISSQTILADFKMEEKNE---------NLAKKRCSEELV .::. .: .:.: .::: . :.::...::.:::: ::.:..:::. gi|149 RENTHVQQLAMKKSTGIKLKPN---QAILVELKMNEKNESLPKLKINENLSKNQCSEQPS 450 460 470 480 490 500 390 400 410 420 430 440 KIAA18 KQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIIL :: . ::.:.:.:: ::.:: ...::.: : :.::.: ::.. .:: .:..::.:. .. gi|149 DQEFNAENVDQKNELENSNLKESVNEQYPWQGLESDTQTEEHV-EHVREEKVGQETEKLF 510 520 530 540 550 560 450 460 470 480 490 500 KIAA18 GHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSL-SL : :::.: ... : ....... ...: .:. .:.: .... ::. :.:: :: gi|149 GFNQEVSAEDSKQAQGVMEETREGLAEEIEIKEMTQQGGP-SDENNSSPISM-QKSLPSL 570 580 590 600 610 620 510 520 530 540 550 560 KIAA18 TSENSKDVRENVILQE-KEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQD : .: . :...: :.: .: ::..::: :.... . ...:. :. .. ::. . :: gi|149 TPDNPEPVERSVTLEEDQETDLKSERIEEIPEEGVLSCDAAVINA-DASVHTEGEADLQD 630 640 650 660 670 680 570 580 590 600 610 620 KIAA18 YVLGRHAPCEGLSNYNAESSMVSKEV-NSLKSEIRNISEKCHENAPEPDS-MTCCVSEST . :. :: : ....:.. ....:: .: ::::.. :: ... : :. .:: ::. : gi|149 SASGKLAPSEEAGSHSANNLLATEEVEDSPKSEIQEALEKGQQTKAEADGVLTCSVSQLT 690 700 710 720 730 740 630 640 650 660 670 680 KIAA18 LLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWD .: :.:::::::.:.:::: :::.:::.::::...: :::: : : :: ::. ::: gi|149 VLSSVEERRLAWVKTFKPWAEIFEQNQHKKIVKKRRLVKCPPNTMPPLDPSAILQYGPWK 750 760 770 780 790 800 690 700 710 720 730 740 KIAA18 TLQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIE .:.:: ..::: :::: :::::::.:::.:::::::::::..::.: .:::::::::::: gi|149 SLKQVPVITFQGLPGCSLSTLAECSNLQILSLRRCGLTSLQGLSHCTRLKYIDAQENHIE 810 820 830 840 850 860 750 760 770 780 790 800 KIAA18 AIECENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNTG :: ::::::: :::::.: :::.::.:::::.: ::::.::::::. .:::.. :. :.: gi|149 AISCENLENLSVVLLNNNLLTSIHGFDGCTNLQSLELSHNKITRINLDFFLKRFLIKNAG 870 880 890 900 910 920 810 820 830 840 850 860 KIAA18 FCHHLGTSTSYLSLAQVWIPTGLCWSWIP--ITSLTKNSDCNFLISHLYWNCGLESLKNL : : ..: : : . : : . : .: : :. :. . .. .:: :::::: : gi|149 HCSHTSNSKLILPLPKQWPPLDILWVTMPDIIYSIMYNT--HVILENLYIPGGLESLKYL 930 940 950 960 970 870 880 890 900 910 920 KIAA18 QQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSL :.: .::::::.:::::..:::::::::::::: ..:. :::::::.::::::: : ::: gi|149 QELTVDHNQLISTKGLCEAPTIVYLDCSHNHLTGIDGIGNCGLLQIIKLQGNYLREPPSL 980 990 1000 1010 1020 1030 930 940 950 960 970 980 KIAA18 ENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHN .: ::::::::::::::.::..:: :::::: ..::::::. ::::::.:::::::::.: gi|149 RNHVLLRELHLDDNSISSVEGLSSCWLPLLQYLSISQNSLATIVPLFHLVSLEKLDVSNN 1040 1050 1060 1070 1080 1090 990 1000 1010 1020 1030 1040 KIAA18 CLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESR ::::: ... ::.:::::.:: :::::.::: :::::.::.:::::.:::..::: ...: gi|149 CLSDLTNVMCWFNACYSLRELCLTGNPVLQEINWRDSILKTLPALRVLNGDMLNSYANDR 1100 1110 1120 1130 1140 1150 1050 1060 1070 1080 1090 1100 KIAA18 TEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEY ::: . .::::: :..::::: :.::: : :..:: ... : .:.: :: :: : gi|149 IEEHYHQDLRCLLALCQYQLQEFNLLPEKYITQKRDILTLHAVDRLSQYYKDLMKLSHEC 1160 1170 1180 1190 1200 1210 1110 1120 1130 1140 1150 1160 KIAA18 RHAHERGDVTITKKDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSV :.:::.:: . :... .:..::: .:.::.::: .... . : ::: . .:.: gi|149 RRAHEQGDFNTTERSAAETNKNHPDFSNTDSALQNKTLHAQTNSCEADSPATSPNPLDTV 1220 1230 1240 1250 1260 1270 1170 1180 1190 1200 1210 1220 KIAA18 SSHSPLSKSATCENMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIE : .. ::...::.:: :. .: :.:. :: . : : :. :..: . ::.: : gi|149 FRPS----TSHCEELRGRNQEKLMAHKSEQSRISSRSNSRASFIEMKMADSPMSNHHNAE 1280 1290 1300 1310 1320 1330 KIAA18 PSEKM : gi|149 RSSPTKAAMVIQAQWRSYIAHRQINCSAEMHPTTTEPLQDPLINNQTTSNEERRKTNMDI 1340 1350 1360 1370 1380 1390 >>gi|194226625|ref|XP_001915618.1| PREDICTED: leucine-ri (1676 aa) initn: 4534 init1: 2256 opt: 3779 Z-score: 3069.2 bits: 580.5 E(): 3e-162 Smith-Waterman score: 5412; 69.779% identity (84.275% similar) in 1221 aa overlap (9-1227:134-1287) 10 20 30 KIAA18 RTRFKDQQEKEEFMRSKTDCATPDFVPEPSPHDLPMDE :::::.:.:: ..:: ::::.::: :..: gi|194 VSNNHVHLKIELSTEDKANPEQLMKMLSEIEKEEFLRNKTHRGSPDSVPEPDPHDSPVNE 110 120 130 140 150 160 40 50 60 70 80 90 KIAA18 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR ::::.::::.::::::::.:.:::::::.:::::::.::.::::::.::::::::::::: gi|194 HVLPEDADIEFGYCEVEERCKQSFEAWQDKQKELEDQEKETLKAQREREEKQFQEEEEKR 170 180 190 200 210 220 100 110 120 130 140 150 KIAA18 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR :::::::.:::::::::::::::::::::..:::.::::::::::.:::::::::::: : gi|194 HCWMKQFEVEKKKLENIQKQEQDKMNDELHREEKMWKEKFKQHEEFIRNLHLQMEEERIR 230 240 250 260 270 280 160 170 180 190 200 210 KIAA18 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK :.: ::::: ::: :.:::.:::::::::::::::::::::::: :::::::::::::: gi|194 FRDLQEKEKMRLLKLQHNAAIKIQAKYKAFVAYQKYGPIIKEQIEIKKRKAQEWKEKEAK 290 300 310 320 330 340 220 230 240 250 260 270 KIAA18 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR ::: :::.::::::::::.:: ::::.:::::::::::.:::.:..:.:::..:::. :: gi|194 IRQMEEEKRKRLEEEQRIEEEIKKQKQEERKRREKEYEDKKNLVRREKEQLLNKEKLRLR 350 360 370 380 390 400 280 290 300 310 320 330 KIAA18 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM :.: .: :.: ::::. : :::..:. ...: ::::. .:.:.: : :::::: . gi|194 EEARKQQIVSRALKKGEGNAKHLTVEETTENKDDIAKKRGNEKSEKLEGDPLWLVEELSN 410 420 430 440 450 460 340 350 360 370 380 390 KIAA18 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD .:::::: ....::::.::::::.:.:::.::::::::::.:..::..::::::: :: : gi|194 RENVDRQLVFRQSIQVQLKESISNQAILAEFKMEEKNENLGKQQCSQKLVKQERKLENID 470 480 490 500 510 520 400 410 420 430 440 450 KIAA18 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQII-LGHNQEISEV .:.:: : ::: :. ::: ::::::..:::: .:: .:.::. :.:::: ::::::: gi|194 QKNELENPDLKENVTEQFQLQELKSQTQKEE-LMKPAITENVRQETQIIILGHNQEIIGE 530 540 550 560 570 580 460 470 480 490 500 510 KIAA18 KTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRE :.:: ::. ::::. ::::::::: .:::: :::... :.:.::. : : :::.:... gi|194 KNNEAQKVTKDNQHDKIQKVEKEE-REQNGTLYKENNISVMSMKQKLLPLKLENSEDIHK 590 600 610 620 630 640 520 530 540 550 560 570 KIAA18 NVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEG :::::::: :::: .:: :::: :. ::::..:. :..::: : :.:.:::..::: gi|194 NVILQEKERDLKSKETQENSKDNALNTD-VIFNVSDATIKVEGKINKQNYILGRQSPCED 650 660 670 680 690 700 580 590 600 610 620 630 KIAA18 LSNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDS-MTCCVSESTLLYSIEERRLAW :.. ::..:.. :::::.::....: :. ::: : . .:: : : .:: ::::.:::: gi|194 LGGCNAKNSLIFKEVNSVKSQMKEIPEEGHENRTECEIILTCSVPEPALLSSIEEKRLAW 710 720 730 740 750 760 640 650 660 670 680 690 KIAA18 IKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQD .::::::.:::::.::::::.::: :::::: : :. :::::::::.:::::::::::: gi|194 MKSFKPWFEIFKQSQQKKIVKRKRLVKCPANTMPPLNTLEILRCGPWNTLQQVTTVTFQD 770 780 790 800 810 820 700 710 720 730 740 750 KIAA18 LPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLCV :::: :::::::.:::::::.::::::::.::::::::::::::::::.: :::: .::: gi|194 LPGCSLSTLAECANLQFLSLQRCGLTSLHNLSNCKKLKYIDAQENHIETISCENLADLCV 830 840 850 860 870 880 760 770 780 790 800 810 KIAA18 VLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNTGFCHHLGTSTSYL :::.::::::.:::::::::: ::::.::::::: gi|194 VLLSKNQLTSFHGLDGCTNIQNLELSHNKITRIG-------------------------- 890 900 910 820 830 840 850 860 870 KIAA18 SLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTK :::::::::.::.::::::.:. gi|194 --------------------------------------GLESLKNLQRLIVDHNQLISTR 920 930 880 890 900 910 920 930 KIAA18 GLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDN ::::::::..::::.::::.:::.:::::::::::::::::::::::: ::::::::::: gi|194 GLCDTPTIIHLDCSYNHLTEVEGIENCGLLQILKLQGNYLSELPSLENHVLLRELHLDDN 940 950 960 970 980 990 940 950 960 970 980 990 KIAA18 SISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDA ::::::::::::::::::.:.::::::::.:::::.::::::::.:::::: :.:::::: gi|194 SISTVEAFSSYWLPLLQNLTLSQNSLTKIIPLFHFISLEKLDVSNNCLSDLTSTIKWFDA 1000 1010 1020 1030 1040 1050 1000 1010 1020 1030 1040 1050 KIAA18 CYSLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFLA ::::.:::::::::::: : : ::::.:::::::::..::: :: :::: :: . ::. gi|194 CYSLRELSLTGNPLLQEINSRHSLLKMLPALRILNGEMLNSYLESPTEEHCQLELGHFLV 1060 1070 1080 1090 1100 1110 1060 1070 1080 1090 1100 1110 KIAA18 LCQSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITKK ::::::::.::: ::::::::...:::.:::::::::::: ::.:::.:::.:::.:::: gi|194 LCQSQIRELNLLTENYITGKGNILTLDAAENLCHYFKKLMALSNEYRYAHEHGDVSITKK 1120 1130 1140 1150 1160 1170 1120 1130 1140 1150 1160 1170 KIAA18 DESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCEN ::::::.:::::::::. ::. ...: : : .:::::: :: .:: :: : .. . ::. gi|194 DESEAQQNHLAPTNSDGILQSRILHSYANEQKPDSPDISEKQVDSGPSHFPSTNLSLCED 1180 1190 1200 1210 1220 1230 1180 1190 1200 1210 1220 KIAA18 MEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKM . :.:: . ::::::::.:::: ::: : ::: :::::..::: ::. gi|194 TKKRNQEKVEGQKREDSKAGSIPTKRIPSMEGVMTRSLLRNNKNIENHEKIMAAMVIQAY 1240 1250 1260 1270 1280 1290 gi|194 WRGYVVRKQIHLSTRLNTAAPGPLTTQANSCIENQPISRKVKRENTVNIQEQREKAAILI 1300 1310 1320 1330 1340 1350 >>gi|194667002|ref|XP_001249913.2| PREDICTED: similar to (1667 aa) initn: 4725 init1: 1819 opt: 3607 Z-score: 2929.8 bits: 554.7 E(): 1.7e-154 Smith-Waterman score: 5180; 67.676% identity (82.079% similar) in 1222 aa overlap (9-1227:121-1272) 10 20 30 KIAA18 RTRFKDQQEKEEFMRSKTDCATPDFVPEPSPHDLPMDE :::::.::.: :..::.: : . :::.:: gi|194 VSNNHMHLRIELPTECKENPEQLIKMLSEIEKEEFLRSRTHCGSPDLVLESDLCDLPVDE 100 110 120 130 140 150 40 50 60 70 80 90 KIAA18 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR ::::::::::::: ::::.:::::::::.:::::::.::.:::..::.:::::::::::: gi|194 HVLPDDADINFGYREVEERCRQSFEAWQDKQKELEDQEKETLKVERDKEEKQFQEEEEKR 160 170 180 190 200 210 100 110 120 130 140 150 KIAA18 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR :: ::::.:::::::::::::::::::::.::::::::.:::: :.:::::::::::::. gi|194 HCLMKQFEVEKKKLENIQKQEQDKMNDELHKEEKIWKERFKQHAEFIRNLHLQMEEERTK 220 230 240 250 260 270 160 170 180 190 200 210 KIAA18 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK ::: ::::: : : :.:::::::::::::::::::::::::::::::.::::::::::: gi|194 FKDLQEKEKMRLSKLQHNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKKKAQEWKEKEAK 280 290 300 310 320 330 220 230 240 250 260 270 KIAA18 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR ::: :::.::::::.:::.:: .:: .: :::::::: ::::..::::::.. ::.::: gi|194 IRQIEEEKRKRLEEKQRIEEEIEKQMQEGRKRREKEYMGKKNILRQEREQLLKMEKLILR 340 350 360 370 380 390 280 290 300 310 320 330 KIAA18 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM : . .::::: ::::. :: ::: .:: :..: :: : : . : ::. ::.:::. gi|194 EATRKQLIISRALKKGEYNAKHLPIEDTSKNKDVGAKRLGDGKLKMWEDASPWLAEESDK 400 410 420 430 440 450 340 350 360 370 380 390 KIAA18 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD ..::::. .::::.::.::::.:::.::: ::.:::..::: . ::::.:::.:.::: : gi|194 RKNVDRELVLKESVQVQLKESMSSQAILAVFKVEEKKKNLAVQ-CSEEFVKQKRNYENRD 460 470 480 490 500 400 410 420 430 440 450 KIAA18 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK .:..: : :: ...::: :::.:..:::: ..: :::. :.::::::.::::.::: gi|194 QKNQLENLHLKEDVREQFQSQELQSQVQKEE-VLKPSINETMRQETQIILGNNQEIDEVK 510 520 530 540 550 560 460 470 480 490 500 510 KIAA18 TNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKD---KDTLVISVKQRSLSLTSENSKDV :: :::. ::::.:.:::::: :. : : ::.. :. :::.::... : :.:. . gi|194 DNESQKIVDDNQQNKMQKVEKE-ISGQLGTLYEENNIKEISVISMKQKQVPLKLEKSEHI 570 580 590 600 610 620 520 530 540 550 560 570 KIAA18 RENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPC ::..:::.:: :::: ::::. .: :: .: :::.:..::.::: : :.:.. ::: gi|194 GENTLLQEEEIDLKSKEAEENPNGSALNSDLV-FNTNDAVINVEGKINKQNYIVD--APC 630 640 650 660 670 680 580 590 600 610 620 630 KIAA18 EGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLA : :..:::.. .: ::::::::.:..: :.::::. : .... : : ::: ::::.::: gi|194 EDLGGYNAKNCLVFKEVNSLKSQIQEIPEECHENTAECENIVACSIEPTLLSSIEEKRLA 690 700 710 720 730 740 640 650 660 670 680 690 KIAA18 WIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQ :: :::::.::::::::::::.:.: .:::.: : :. :::::::::::::::.:.::: gi|194 WITSFKPWFEIFKQNQQKKIVKRRRIIKCPVNTMPPLNPLEILRCGPWDTLQQVATITFQ 750 760 770 780 790 800 700 710 720 730 740 750 KIAA18 DLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLC ::::: ::::::: ::::::::::::::::::::::.::::::::::::.:.:::::::: gi|194 DLPGCSLSTLAECPNLQFLSLRRCGLTSLHSLSNCKRLKYIDAQENHIETINCENLENLC 810 820 830 840 850 860 760 770 780 790 800 810 KIAA18 VVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNTGFCHHLGTSTSY .::::::::::::::::::::: ::::.::::::: gi|194 IVLLNKNQLTSLHGLDGCTNIQSLELSHNKITRIG------------------------- 870 880 890 820 830 840 850 860 870 KIAA18 LSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINT ::::::::::::.::::::.: gi|194 ---------------------------------------GLESLKNLQQLIVDHNQLIST 900 910 920 880 890 900 910 920 930 KIAA18 KGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDD :::::::..::::::::::.:::.:.:::::::::::::::::: : : :::::::::: gi|194 TGLCDTPTLMYLDCSHNHLTEVEGIEQCGLLQILKLQGNYLSELPFLGNHVLLRELHLDD 930 940 950 960 970 980 940 950 960 970 980 990 KIAA18 NSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFD :::::::.:::::::::: .::::::::::.::::::::::::::.:::::: ::::::: gi|194 NSISTVETFSSYWLPLLQILTISQNSLTKIAPLFHFVSLEKLDVSNNCLSDLTSAIKWFD 990 1000 1010 1020 1030 1040 1000 1010 1020 1030 1040 1050 KIAA18 ACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFL ::.::::::::::::::: ::: ::::.:::::::::..:.: .: .:: :.:: :: gi|194 ACFSLHELSLTGNPLLQEINWRHSLLKILPALRILNGEMLTSCTERHTEGHHQLELEHFL 1050 1060 1070 1080 1090 1100 1060 1070 1080 1090 1100 1110 KIAA18 ALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITK ::::::::::: :.:::: ..::::.:.:::.:::::: ::.: : .::.:::..:. gi|194 EHCQSQIREFNLLSEKYITGDRNIFTLDVAQNLCYYFKKLMTLSNECRCVHEHGDVSMTR 1110 1120 1130 1140 1150 1160 1120 1130 1140 1150 1160 1170 KIAA18 KDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCE . :::::.::: ::.::: :: :.:: : : . .:::: :::::: :::: .. . :: gi|194 RGESEAQQNHLPPTHSDSKQQNRVLYSSANEYKLNSPDISEKWMDSGSSHSSSTNPSLCE 1170 1180 1190 1200 1210 1220 1180 1190 1200 1210 1220 KIAA18 NMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKM . . :.:: .: :::::::.::.:. :::: :.: : ::.: :: : ::. gi|194 DTKERNQEEIVDQKREDSKTSSFPSKRIPFIETVRTRFLLENCQNTEHHEKIMAAMVIQA 1230 1240 1250 1260 1270 1280 gi|194 YWRGYIVRRQIHFSAKLHPATIGPLTSKPNSCIENQTILKKEKVKNTVNIQEQKEKAAIL 1290 1300 1310 1320 1330 1340 >>gi|10433748|dbj|BAB14022.1| unnamed protein product [H (534 aa) initn: 2710 init1: 2710 opt: 2710 Z-score: 2208.1 bits: 419.5 E(): 2.7e-114 Smith-Waterman score: 2710; 100.000% identity (100.000% similar) in 417 aa overlap (9-425:118-534) 10 20 30 KIAA18 RTRFKDQQEKEEFMRSKTDCATPDFVPEPSPHDLPMDE :::::::::::::::::::::::::::::: gi|104 VSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDE 90 100 110 120 130 140 40 50 60 70 80 90 KIAA18 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|104 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR 150 160 170 180 190 200 100 110 120 130 140 150 KIAA18 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|104 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR 210 220 230 240 250 260 160 170 180 190 200 210 KIAA18 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|104 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 270 280 290 300 310 320 220 230 240 250 260 270 KIAA18 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|104 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR 330 340 350 360 370 380 280 290 300 310 320 330 KIAA18 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|104 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM 390 400 410 420 430 440 340 350 360 370 380 390 KIAA18 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|104 KENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTD 450 460 470 480 490 500 400 410 420 430 440 450 KIAA18 NKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVK ::::::::::::::::::::::::::: gi|104 NKTELGNSDLKGNLKEQFPLQELKSDA 510 520 530 >>gi|148689728|gb|EDL21675.1| mCG15787 [Mus musculus] (866 aa) initn: 2042 init1: 1376 opt: 2465 Z-score: 2007.1 bits: 383.0 E(): 4.3e-103 Smith-Waterman score: 2465; 53.289% identity (79.597% similar) in 745 aa overlap (9-739:126-861) 10 20 30 KIAA18 RTRFKDQQEKEEFMRSKTDCATPDFVPEPSPHDLPMDE :::::::: . : : : : :::: gi|148 VTDSHMHLRTGSLPESKANAEQLMKILSVIEKEEFMRSLAPSARCVSVREIITPDTPMDE 100 110 120 130 140 150 40 50 60 70 80 90 KIAA18 HVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKR ..:::.::..::: ::::.::.::::::.::.:::.:.:.::.:: .::.. ::::.::: gi|148 YILPDEADLSFGYFEVEERCRKSFEAWQDKQQELEEKDKETLEAQNEREKRTFQEEDEKR 160 170 180 190 200 210 100 110 120 130 140 150 KIAA18 HCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTR .:::.::.::::.::..:::.::::::::.:::::::::..::::.::::::.::::::: gi|148 QCWMRQFEVEKKHLEDLQKQDQDKMNDELHKEEKIWKEKYRQHEEHIRNLHLKMEEERTR 220 230 240 250 260 270 160 170 180 190 200 210 KIAA18 FKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK ... ::::: :.: . .::::::: :.: :.:.::.::::::.:.:.:.::: :::::: gi|148 LSELQEKEKARLFKLRYDAAVKIQATYRASVTYRKYSPIIKEQMEKKRRRAQELKEKEAK 280 290 300 310 320 330 220 230 240 250 260 270 KIAA18 IRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILR :::::::.:.:::::::..::.::. :::.:::.::::::.:..::::. ::: : :: gi|148 IRQKEEEKRRRLEEEQRVEEEKKKKMLEERRRREREYEEKKSILRQEREEQRSKEVIRLR 340 350 360 370 380 390 280 290 300 310 320 330 KIAA18 EDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNM : : . :::. ::::. ..:. .. . . :: :::. :: :::::::. : ... : gi|148 EHAHSPLIITCALKKGDCHGKQQAIAHVPKGKGTIAKESVDSNSKKQEDACL--AQQLNK 400 410 420 430 440 450 340 350 360 370 380 KIAA18 KENVD-RQTILKESIQVKLKESISSQTILADFKMEEKNE---------NLAKKRCSEELV .::. .: .:.: .::: .:.::...::.:::: ::.:..:::. gi|148 RENTHVQQLAMKKSTGIKLKP---NQAILVELKMNEKNESLPKLKINENLSKNQCSEQPS 460 470 480 490 500 510 390 400 410 420 430 440 KIAA18 KQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIIL :: . ::.:.:.:: ::.:: ...::.: : :.::.: ::.. .:: .:..::.:. .. gi|148 DQEFNAENVDQKNELENSNLKESVNEQYPWQGLESDTQTEEHV-EHVREEKVGQETEKLF 520 530 540 550 560 450 460 470 480 490 500 KIAA18 GHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSL-SL : :::.: ... : ....... ...: .:. .:.: .... ::. :.:: :: gi|148 GFNQEVSAEDSKQAQGVMEETREGLAEEIEIKEMTQQGGP-SDENNSSPISM-QKSLPSL 570 580 590 600 610 620 510 520 530 540 550 560 KIAA18 TSENSKDVRENVILQE-KEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQD : .: . :...: :.: .: ::..::: :.... . ...:. :. .. ::. . :: gi|148 TPDNPEPVERSVTLEEDQETDLKSERIEEIPEEGVLSCDAAVINA-DASVHTEGEADLQD 630 640 650 660 670 680 570 580 590 600 610 620 KIAA18 YVLGRHAPCEGLSNYNAESSMVSKEV-NSLKSEIRNISEKCHENAPEPDS-MTCCVSEST . :. :: : ....:.. ....:: .: ::::.. :: ... : :. .:: ::. : gi|148 SASGKLAPSEEAGSHSANNLLATEEVEDSPKSEIQEALEKGQQTKAEADGVLTCSVSQLT 690 700 710 720 730 740 630 640 650 660 670 680 KIAA18 LLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWD .: :.:::::::.:.:::: :::.:::.::::...: :::: : : :: ::. ::: gi|148 VLSSVEERRLAWVKTFKPWAEIFEQNQHKKIVKKRRLVKCPPNTMPPLDPSAILQYGPWK 750 760 770 780 790 800 690 700 710 720 730 740 KIAA18 TLQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIE .:.:: ..::: :::: :::::::.:::.:::::::::::..::.: .::::::: gi|148 SLKQVPVITFQGLPGCSLSTLAECSNLQILSLRRCGLTSLQGLSHCTRLKYIDAQARKPH 810 820 830 840 850 860 750 760 770 780 790 800 KIAA18 AIECENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNTG 1227 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Thu Mar 5 19:24:43 2009 done: Thu Mar 5 19:28:28 2009 Total Scan time: 1793.180 Total Display time: 1.110 Function used was FASTA [version 34.26.5 April 26, 2007]