# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/fh25862s1.fasta.nr -Q ../query/KIAA1686.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1686, 1175 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7821657 sequences Expectation_n fit: rho(ln(x))= 5.7618+/-0.000194; mu= 11.8985+/- 0.011 mean_var=99.4023+/-18.932, 0's: 34 Z-trim: 61 B-trim: 161 in 2/64 Lambda= 0.128640 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 39, opt: 27, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|119616798|gb|EAW96392.1| pleckstrin homology do (1174) 7768 1453.1 0 gi|119616800|gb|EAW96394.1| pleckstrin homology do (1179) 6161 1154.9 0 gi|109095897|ref|XP_001093182.1| PREDICTED: simila ( 965) 5672 1064.0 0 gi|114643774|ref|XP_520779.2| PREDICTED: pleckstri (1235) 5489 1030.2 0 gi|194382860|dbj|BAG58986.1| unnamed protein produ ( 977) 4793 900.9 0 gi|148678660|gb|EDL10607.1| pleckstrin homology do (1089) 4617 868.3 0 gi|194379232|dbj|BAG58167.1| unnamed protein produ (1183) 4529 852.0 0 gi|73997574|ref|XP_534874.2| PREDICTED: similar to (1284) 4428 833.3 0 gi|149049101|gb|EDM01555.1| pleckstrin homology do (1049) 4306 810.6 0 gi|110835706|ref|NP_659169.3| phosphoinositol 3-ph (1269) 4224 795.4 0 gi|119616802|gb|EAW96396.1| pleckstrin homology do (1060) 4169 785.1 0 gi|48474955|sp|Q9HAU0.1|PKHA5_HUMAN RecName: Full= (1116) 4169 785.2 0 gi|109472822|ref|XP_342782.3| PREDICTED: similar t (1186) 3839 723.9 1.3e-205 gi|119892926|ref|XP_612103.3| PREDICTED: similar t (1070) 3635 686.0 3e-194 gi|148678659|gb|EDL10606.1| pleckstrin homology do (1026) 3474 656.1 2.9e-185 gi|194386930|dbj|BAG59831.1| unnamed protein produ ( 914) 3423 646.6 1.9e-182 gi|219689123|ref|NP_001137293.1| pleckstrin homolo (1105) 3419 646.0 3.6e-182 gi|194378264|dbj|BAG57882.1| unnamed protein produ (1098) 3415 645.2 5.9e-182 gi|149049103|gb|EDM01557.1| pleckstrin homology do ( 574) 3336 630.3 9.5e-178 gi|21239256|gb|AAM44231.1|AF468695_1 phosphoinosit ( 574) 3329 629.0 2.3e-177 gi|117558782|gb|AAI27092.1| PLEKHA5 protein [Homo ( 874) 3289 621.8 5.5e-175 gi|34189241|gb|AAH13133.3| PLEKHA5 protein [Homo s ( 529) 3260 616.2 1.6e-173 gi|118083033|ref|XP_416414.2| PREDICTED: similar t (1075) 3227 610.3 1.9e-171 gi|149049102|gb|EDM01556.1| pleckstrin homology do ( 986) 3145 595.1 6.7e-167 gi|12654297|gb|AAH00969.1| PLEKHA5 protein [Homo s ( 492) 3072 581.3 4.8e-163 gi|10434907|dbj|BAB14419.1| unnamed protein produc ( 438) 2853 540.6 7.5e-151 gi|23274067|gb|AAH33481.1| Plekha5 protein [Mus mu ( 853) 2482 472.0 6.6e-130 gi|94732714|emb|CAI11873.2| novel protein similar (1137) 2387 454.4 1.6e-124 gi|194211759|ref|XP_001497882.2| PREDICTED: plecks ( 875) 2370 451.2 1.2e-123 gi|18204502|gb|AAH21505.1| Plekha5 protein [Mus mu ( 645) 2356 448.5 5.8e-123 gi|47124507|gb|AAH70174.1| PLEKHA5 protein [Homo s ( 320) 2119 404.2 6e-110 gi|21739814|emb|CAD38934.1| hypothetical protein [ ( 501) 2065 394.4 8.8e-107 gi|7022841|dbj|BAA91742.1| unnamed protein product ( 292) 1805 345.9 2e-92 gi|189517883|ref|XP_695683.3| PREDICTED: si:ch211- (1238) 1654 318.4 1.6e-83 gi|161611972|gb|AAI55855.1| Si:ch211-239h19.1 prot (1237) 1647 317.1 3.9e-83 gi|194037808|ref|XP_001925914.1| PREDICTED: simila ( 448) 1368 265.0 7e-68 gi|147721051|sp|Q3UIL6.2|PKHA7_MOUSE RecName: Full (1118) 1263 245.8 1e-61 gi|74147168|dbj|BAE27490.1| unnamed protein produc (1266) 1263 245.9 1.1e-61 gi|109107165|ref|XP_001086202.1| PREDICTED: simila (1430) 1237 241.1 3.5e-60 gi|47938135|gb|AAH71599.1| Pleckstrin homology dom (1121) 1233 240.3 4.8e-60 gi|215273867|sp|Q6IQ23.2|PKHA7_HUMAN RecName: Full (1121) 1231 239.9 6.2e-60 gi|168278373|dbj|BAG11066.1| pleckstrin homology d (1272) 1231 240.0 6.8e-60 gi|189521217|ref|XP_001344241.2| PREDICTED: simila (1266) 1207 235.5 1.5e-58 gi|126332423|ref|XP_001378708.1| PREDICTED: hypoth (1451) 1141 223.3 8.1e-55 gi|15928787|gb|AAH14853.1| Plekha5 protein [Mus mu ( 708) 1101 215.6 8.1e-53 gi|165970705|gb|AAI58708.1| Plekha5 protein [Rattu ( 270) 1081 211.5 5.2e-52 gi|83405611|gb|AAI10775.1| LOC733439 protein [Xeno (1257) 1054 207.1 5.3e-50 gi|47224468|emb|CAG08718.1| unnamed protein produc ( 812) 1038 204.0 3e-49 gi|170785873|gb|ACB38002.1| heart adaptor protein (1197) 1002 197.4 4.1e-47 gi|170785877|gb|ACB38004.1| heart adaptor protein (1220) 982 193.7 5.4e-46 >>gi|119616798|gb|EAW96392.1| pleckstrin homology domain (1174 aa) initn: 7768 init1: 7768 opt: 7768 Z-score: 7788.5 bits: 1453.1 E(): 0 Smith-Waterman score: 7768; 100.000% identity (100.000% similar) in 1174 aa overlap (2-1175:1-1174) 10 20 30 40 50 60 KIAA16 DMAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLP 10 20 30 40 50 70 80 90 100 110 120 KIAA16 TGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPI 60 70 80 90 100 110 130 140 150 160 170 180 KIAA16 SMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQ 120 130 140 150 160 170 190 200 210 220 230 240 KIAA16 DSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAA 180 190 200 210 220 230 250 260 270 280 290 300 KIAA16 HPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 HPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVL 240 250 260 270 280 290 310 320 330 340 350 360 KIAA16 IKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 IKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSAC 300 310 320 330 340 350 370 380 390 400 410 420 KIAA16 PAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIK 360 370 380 390 400 410 430 440 450 460 470 480 KIAA16 IQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 IQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPST 420 430 440 450 460 470 490 500 510 520 530 540 KIAA16 HDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 HDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMH 480 490 500 510 520 530 550 560 570 580 590 600 KIAA16 SIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPA 540 550 560 570 580 590 610 620 630 640 650 660 KIAA16 GLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEIL 600 610 620 630 640 650 670 680 690 700 710 720 KIAA16 SHHLQRNTIYLDHQLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SHHLQRNTIYLDHQLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHK 660 670 680 690 700 710 730 740 750 760 770 780 KIAA16 EKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 EKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWRE 720 730 740 750 760 770 790 800 810 820 830 840 KIAA16 YDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 YDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGT 780 790 800 810 820 830 850 860 870 880 890 900 KIAA16 TEIGMIGSKPFSTVKYKNEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TEIGMIGSKPFSTVKYKNEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKG 840 850 860 870 880 890 910 920 930 940 950 960 KIAA16 SHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMT 900 910 920 930 940 950 970 980 990 1000 1010 1020 KIAA16 VEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDT 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 KIAA16 AIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMM 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 KIAA16 DKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGN 1080 1090 1100 1110 1120 1130 1150 1160 1170 KIAA16 QTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV ::::::::::::::::::::::::::::::::::: gi|119 QTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV 1140 1150 1160 1170 >>gi|119616800|gb|EAW96394.1| pleckstrin homology domain (1179 aa) initn: 7374 init1: 4142 opt: 6161 Z-score: 6176.7 bits: 1154.9 E(): 0 Smith-Waterman score: 7140; 90.218% identity (90.218% similar) in 1237 aa overlap (2-1175:1-1179) 10 20 30 40 50 60 KIAA16 DMAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLP 10 20 30 40 50 70 80 90 100 110 120 KIAA16 TGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPI 60 70 80 90 100 110 130 140 150 160 170 180 KIAA16 SMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQ 120 130 140 150 160 170 190 200 210 220 230 240 KIAA16 DSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAA 180 190 200 210 220 230 250 260 270 280 290 300 KIAA16 HPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 HPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVL 240 250 260 270 280 290 310 320 330 340 350 360 KIAA16 IKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 IKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSAC 300 310 320 330 340 350 370 380 390 400 410 420 KIAA16 PAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIK 360 370 380 390 400 410 430 440 450 460 470 480 KIAA16 IQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 IQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPST 420 430 440 450 460 470 490 500 510 520 530 540 KIAA16 HDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 HDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMH 480 490 500 510 520 530 550 560 570 580 590 600 KIAA16 SIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPA 540 550 560 570 580 590 610 620 630 640 650 660 KIAA16 GLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEIL :::::::::::::::: gi|119 GLTLQSVSPQSLQGKT-------------------------------------------- 600 610 670 680 690 700 710 720 KIAA16 SHHLQRNTIYLDHQLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHK :::::::::::::::::::::::::::::::::::::::::::::: gi|119 --------------LSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHK 620 630 640 650 660 730 740 750 760 770 780 KIAA16 EKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 EKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWRE 670 680 690 700 710 720 790 800 810 820 830 840 KIAA16 YDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 YDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGT 730 740 750 760 770 780 850 KIAA16 TEIGMIGSKPFSTVKYKNE----------------------------------------- ::::::::::::::::::: gi|119 TEIGMIGSKPFSTVKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGP 790 800 810 820 830 840 860 870 880 890 KIAA16 ----------------------GPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSV :::::::::::::::::::::::::::::::::::::: gi|119 VHLPEEKKMYQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSV 850 860 870 880 890 900 900 910 920 930 940 950 KIAA16 VKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRP 910 920 930 940 950 960 960 970 980 990 1000 1010 KIAA16 RMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKE 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 KIAA16 LDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSV 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 KIAA16 EMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 EMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVS 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 KIAA16 RGNQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV :::::::::::::::::::::::::::::::::::::: gi|119 RGNQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV 1150 1160 1170 >>gi|109095897|ref|XP_001093182.1| PREDICTED: similar to (965 aa) initn: 5998 init1: 5672 opt: 5672 Z-score: 5687.4 bits: 1064.0 E(): 0 Smith-Waterman score: 5804; 92.435% identity (93.472% similar) in 965 aa overlap (2-903:1-965) 10 20 30 40 50 60 KIAA16 DMAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLP 10 20 30 40 50 70 80 90 100 110 120 KIAA16 TGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 TGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPI 60 70 80 90 100 110 130 140 150 160 170 180 KIAA16 SMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 SMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQ 120 130 140 150 160 170 190 200 210 220 230 240 KIAA16 DSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 DSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAA 180 190 200 210 220 230 250 260 270 280 290 300 KIAA16 HPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVL ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: gi|109 HPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKESNNIPNHRVL 240 250 260 270 280 290 310 320 330 340 350 360 KIAA16 IKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 IKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSAC 300 310 320 330 340 350 370 380 390 400 410 420 KIAA16 PAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIK ::::.::::.::.::::::::::::::::::::.:::::::::::::::::::::::::: gi|109 PAQTAHYRPVNLNSSENKIVNVSLADLRGGNRPSTGPLYTEADRVIQRTNSMQQLEQWIK 360 370 380 390 400 410 430 440 450 460 470 480 KIAA16 IQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPST ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: gi|109 IQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVAPST 420 430 440 450 460 470 490 500 510 520 530 540 KIAA16 HDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 HDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMH 480 490 500 510 520 530 550 560 570 580 590 600 KIAA16 SIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 SIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPA 540 550 560 570 580 590 610 620 630 640 650 660 KIAA16 GLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 GLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEIL 600 610 620 630 640 650 670 680 690 700 710 720 KIAA16 SHHLQRNTIYLDHQLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 SHHLQRNTIYLDHQLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHK 660 670 680 690 700 710 730 740 750 760 770 780 KIAA16 EKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 EKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWRE 720 730 740 750 760 770 790 800 810 820 830 840 KIAA16 YDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 YDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGT 780 790 800 810 820 830 850 KIAA16 TEIGMIGSKPFSTVKYKNE----------------------------------------- :::::.:::::::::::.: gi|109 TEIGMVGSKPFSTVKYKSEEEEVVPPRPPLPWSYDFTEQPPIIPPLPSDSSSLLCYSRGP 840 850 860 870 880 890 860 870 880 890 KIAA16 ----------------------GPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSV :::::::::::::::::::::::::::::::::::::: gi|109 VHLPEEKKMYQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSV 900 910 920 930 940 950 900 910 920 930 940 950 KIAA16 VKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRP :::.:. gi|109 VKGQHL 960 >>gi|114643774|ref|XP_520779.2| PREDICTED: pleckstrin ho (1235 aa) initn: 7505 init1: 5489 opt: 5489 Z-score: 5502.4 bits: 1030.2 E(): 0 Smith-Waterman score: 7383; 94.210% identity (94.541% similar) in 1209 aa overlap (32-1175:27-1235) 10 20 30 40 50 60 KIAA16 MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPT :::::::::::::::::::::::::::::: gi|114 MNLVVSKDLELKGIPVLHMVNLQASREEAKSTTWLHPVTGEAVVTGHRRQSTDLPT 10 20 30 40 50 70 80 90 100 110 120 KIAA16 GWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPIS 60 70 80 90 100 110 130 140 150 160 170 180 KIAA16 MINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 MINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD 120 130 140 150 160 170 190 200 210 220 230 240 KIAA16 STGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 STGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAH 180 190 200 210 220 230 250 260 270 280 290 300 KIAA16 PNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLI 240 250 260 270 280 290 310 320 330 340 350 360 KIAA16 KPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACP 300 310 320 330 340 350 370 380 390 400 410 420 KIAA16 AQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKI :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 AQTAHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKI 360 370 380 390 400 410 430 440 450 460 470 480 KIAA16 QKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTH 420 430 440 450 460 470 490 500 510 520 530 540 KIAA16 DKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHS 480 490 500 510 520 530 550 560 570 580 590 600 KIAA16 IPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAG 540 550 560 570 580 590 610 620 630 640 650 660 KIAA16 LTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILS 600 610 620 630 640 650 670 680 690 700 710 720 KIAA16 HHLQRNTIYLDHQLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 HHLQRNTIYLDHQLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKE 660 670 680 690 700 710 730 740 750 760 770 780 KIAA16 KYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREY 720 730 740 750 760 770 790 800 810 820 830 840 KIAA16 DKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTT 780 790 800 810 820 830 850 KIAA16 EIGMIGSKPFSTVKYKNE------------------------------------------ :::::::::::::::::: gi|114 EIGMIGSKPFSTVKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPV 840 850 860 870 880 890 860 870 880 890 KIAA16 ---------------------GPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVV ::::::::::::::::::::::::::::::::::::::: gi|114 HLPEEKKMYQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVV 900 910 920 930 940 950 900 910 920 930 940 950 KIAA16 KGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPR 960 970 980 990 1000 1010 960 970 980 990 1000 1010 KIAA16 MTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDD--K ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : gi|114 MTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDNVK 1020 1030 1040 1050 1060 1070 1020 1030 1040 1050 1060 1070 KIAA16 ELDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ELDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNS 1080 1090 1100 1110 1120 1130 1080 1090 1100 1110 1120 1130 KIAA16 VEMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEV ::::::::::.:::::::.::::::: .:::::::::::::::::::::::::::::::: gi|114 VEMMDKERNKEKMPEDVTYSPQDETQITNHKPEEHPEENTKNSVDEQEETVISYESTPEV 1140 1150 1160 1170 1180 1190 1140 1150 1160 1170 KIAA16 SRGNQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV ::::::::::::::::::::::::::::::::::::::: gi|114 SRGNQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV 1200 1210 1220 1230 >>gi|194382860|dbj|BAG58986.1| unnamed protein product [ (977 aa) initn: 6006 init1: 3396 opt: 4793 Z-score: 4805.7 bits: 900.9 E(): 0 Smith-Waterman score: 5772; 88.309% identity (88.309% similar) in 1035 aa overlap (110-1081:1-977) 80 90 100 110 120 130 KIAA16 ERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHP :::::::::::::::::::::::::::::: gi|194 MTSEEKKERPISMINEASNYNVTSDYAVHP 10 20 30 140 150 160 170 180 190 KIAA16 MSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 MSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLC 40 50 60 70 80 90 200 210 220 230 240 250 KIAA16 LFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 LFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMEL 100 110 120 130 140 150 260 270 280 290 300 310 KIAA16 WMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 WMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEE 160 170 180 190 200 210 320 330 340 350 360 370 KIAA16 KKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 KKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKI 220 230 240 250 260 270 380 390 400 410 420 430 KIAA16 VNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 VNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQT 280 290 300 310 320 330 440 450 460 470 480 490 KIAA16 LPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 LPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDD 340 350 360 370 380 390 500 510 520 530 540 550 KIAA16 TMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 TMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSP 400 410 420 430 440 450 560 570 580 590 600 610 KIAA16 QRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 QRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKT--- 460 470 480 490 500 620 630 640 650 660 670 KIAA16 LTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQLSQDE ::::: gi|194 -------------------------------------------------------LSQDE 510 680 690 700 710 720 730 KIAA16 GRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 GRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMH 520 530 540 550 560 570 740 750 760 770 780 790 KIAA16 ADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 ADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQL 580 590 600 610 620 630 800 810 820 830 840 850 KIAA16 DHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 DHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNE 640 650 660 670 680 690 KIAA16 ------------------------------------------------------------ gi|194 EEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNG 700 710 720 730 740 750 860 870 880 890 900 910 KIAA16 ---GPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 SHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPT 760 770 780 790 800 810 920 930 940 950 960 970 KIAA16 PESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 PESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACL 820 830 840 850 860 870 980 990 1000 1010 1020 1030 KIAA16 REKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 REKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPAT 880 890 900 910 920 930 1040 1050 1060 1070 1080 1090 KIAA16 EIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFS ::::::::::::::::::::::::::::::::::::::::::::: gi|194 EIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMD 940 950 960 970 1100 1110 1120 1130 1140 1150 KIAA16 PQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESSA >>gi|148678660|gb|EDL10607.1| pleckstrin homology domain (1089 aa) initn: 4430 init1: 2650 opt: 4617 Z-score: 4628.5 bits: 868.3 E(): 0 Smith-Waterman score: 5501; 75.107% identity (83.433% similar) in 1165 aa overlap (58-1157:1-1089) 30 40 50 60 70 80 KIAA16 FFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKH :::::::::::::::::::::::::::::: gi|148 DLPTGWEEAYTFEGARYYINHNERKVTCKH 10 20 30 90 100 110 120 130 140 KIAA16 PVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTS ::::::::::::::::.:::::::::.::::::::::::::::..::::::::::::::: gi|148 PVTGQPSQDNCIFVVNDQTVATMTSEDKKERPISMINEASNYNMASDYAVHPMSPVGRTS 40 50 60 70 80 90 150 160 170 180 190 200 KIAA16 RASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 RASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEK 100 110 120 130 140 150 210 220 230 240 250 260 KIAA16 EEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDA ::::::::::::::::.::.:::::::::::::::::::::::::::::::::::::::: gi|148 EEGILGSILLPSFQIAMLTAEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDA 160 170 180 190 200 210 270 280 290 300 310 320 KIAA16 ALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEK :::::::::::::::...: ::::::::::::::.::.::.:::::.::::::.:::::. gi|148 ALVQTEPVKRVDKITTDSASTKETNNIPNHRVLIRPEVQNHQKNKEISKIEEKRALEAER 220 230 240 250 260 270 330 340 350 360 370 380 KIAA16 YGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADL ::::::::::::::::::::::: :::::: :: :.:::::::..::..: :::::::. gi|148 YGFQKDGQDRPLTKINSVKLNSLLSEYESGPDCPPQNVHYRPINVNSSDGKAVNVSLADV 280 290 300 310 320 330 390 400 410 420 430 440 KIAA16 RGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSH :::..::.::: :::::::::::::::::::::.::::: ::: :::::::::::::::: gi|148 RGGSHPNAGPLATEADRVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQTLPRNMPSH 340 350 360 370 380 390 450 460 470 480 490 500 KIAA16 RAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEW ::::.:: :::::::::::::::::::::: : :.:: :::::::::::::::::::::: gi|148 RAQILARCPEGYRTLPRNSKTRPESICSVTSSGHEKT-GPGAEEKRRSMRDDTMWQLYEW 400 410 420 430 440 510 520 530 540 550 560 KIAA16 QQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEV ::::::.::::::::. :::::.::..:::::::::::::::: :::::.:::::::::: gi|148 QQRQFYHKQSTLPRHGCLSSPKAMVQVSDQTMHSIPTSPSHGSAAAYQGFSPQRTYRSEV 450 460 470 480 490 500 570 580 590 600 610 620 KIAA16 SSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEELTLLLIKL .::::::::::::::: :::::::: ::::.:::::::.::::::::.: gi|148 TSPIQRGDVTIDRRHRPHHPKHVYVADRRSMPAGLTLQAVSPQSLQGRT----------- 510 520 530 540 550 630 640 650 660 670 680 KIAA16 RRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQLSQDEGRGTLYKY ::::: ::::::: gi|148 -----------------------------------------------LSQDECRGTLYKY 560 570 690 700 710 720 730 740 KIAA16 RPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQ ::::. :::::::::::::::.:::::::::::::::::::::::::::::.:::::::: gi|148 RPEEAGIDAKLSRLCEQDKVVRALEEKLQQLHKEKYTLEQALLSASQEIEMNADNPAAIQ 580 590 600 610 620 630 750 760 770 780 790 800 KIAA16 TVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQT :::::::::::::::::::::::::::::::::::::::::::::.::: :::.:::::. gi|148 TVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRDQMQGQLDRLGEVQS 640 650 660 670 680 690 810 820 830 840 850 KIAA16 ESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNE-------- ::::::::::::::::::::::::::::::::..: :. ::::::.::::.: gi|148 ESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSETGLAGSKPFSSVKYKSEEEEVVPPR 700 710 720 730 740 750 860 KIAA16 -------------------------------------------------------GPDYR ::::: gi|148 PPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEDKKIHQVQGYPRNGSHCGPDYR 760 770 780 790 800 810 870 880 890 900 910 920 KIAA16 LYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIAS :::::::::::::::::::::::::::: :. ::::::::::: : :.:::::::::::: gi|148 LYKSEPELTTVAEVDESNGEEKSEPVSETEAPVVKGSHFPVGV-PLRTKSPTPESSTIAS 820 830 840 850 860 870 930 940 950 960 970 980 KIAA16 YVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLN ::::::::::..::::::::::::::::::.:::::::::.::::::::::::::::::. gi|148 YVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLERIRRHQQACLREKKKGLS 880 890 900 910 920 930 990 1000 1010 1020 1030 1040 KIAA16 VIGASDQSPLQSPSNLRDNPFRTTQTRRRDD--KELDTAIRENDVKPDHETPATEIVQLK :.:::: ::..::.:.: ::: :::: :::::. ::::::::.::::.. ..:. gi|148 VLGASD------PSDVRDSPLRLTQTLRRDDNVKELDTVHRENDVKPDYETPAAQCAHLE 940 950 960 970 980 1050 1060 1070 1080 1090 1100 KIAA16 ETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQDETQ ..::::.:....::..: ::. :::::. : :. .:::.:... : . :::.:: gi|148 DAEPQNADIGRKLKRSE-----MLYTPEPNGMASEEVTEKERQKEQVHADGSCSPQEETA 990 1000 1010 1020 1030 1110 1120 1130 1140 1150 1160 KIAA16 TANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESSASPVPST ..:. : ::: .:. :.:::. : : .::. : ::: :. . : ::: : gi|148 MTEHQMEGPPEEA--ESLHEEEETLASCEPAPEIPRENQTTAALA---SVESSQS 1040 1050 1060 1070 1080 1170 KIAA16 QPQLTEGSHFMCV >>gi|194379232|dbj|BAG58167.1| unnamed protein product [ (1183 aa) initn: 4365 init1: 2651 opt: 4529 Z-score: 4539.8 bits: 852.0 E(): 0 Smith-Waterman score: 6851; 90.488% identity (90.488% similar) in 1188 aa overlap (2-1081:1-1183) 10 20 30 40 50 60 KIAA16 DMAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLP 10 20 30 40 50 70 80 90 100 110 120 KIAA16 TGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 TGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPI 60 70 80 90 100 110 130 140 150 160 170 180 KIAA16 SMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 SMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQ 120 130 140 150 160 170 190 200 210 220 230 240 KIAA16 DSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 DSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAA 180 190 200 210 220 230 250 260 270 280 290 KIAA16 HPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKR------VDKITSENAPTKETNNI ::::::::::::::::::::::::::::::::::::: ::::::::::::::::: gi|194 HPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITSENAPTKETNNI 240 250 260 270 280 290 300 310 320 330 340 350 KIAA16 PNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 PNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEY 300 310 320 330 340 350 360 370 380 390 400 410 KIAA16 ESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 ESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQ 360 370 380 390 400 410 420 430 440 450 460 470 KIAA16 LEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 LEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESIC 420 430 440 450 460 470 480 490 500 510 520 530 KIAA16 SVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 SVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNI 480 490 500 510 520 530 540 550 560 570 580 590 KIAA16 SDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 SDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPD 540 550 560 570 580 590 600 610 620 630 640 650 KIAA16 RRSVPAGLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 RRSVPAGLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHS 600 610 620 630 640 650 660 670 KIAA16 PKNEILSHHLQRNTIYLDHQ---------------------------------------L :::::::::::::::::::: : gi|194 PKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKSKISLYCL 660 670 680 690 700 710 680 690 700 710 720 730 KIAA16 SQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 SQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQE 720 730 740 750 760 770 740 750 760 770 780 790 KIAA16 IEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 IEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQM 780 790 800 810 820 830 800 810 820 830 840 850 KIAA16 QEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVK :::::::::::::::::::::::::::::::::::::::::::: ::::::::::: gi|194 QEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRG-----MIGSKPFSTVK 840 850 860 870 880 890 KIAA16 YKNE-------------------------------------------------------- :::: gi|194 YKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGY 900 910 920 930 940 950 860 870 880 890 900 910 KIAA16 -------GPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRA ::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 PRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRA 960 970 980 990 1000 1010 920 930 940 950 960 970 KIAA16 KSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 KSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQ 1020 1030 1040 1050 1060 1070 980 990 1000 1010 1020 1030 KIAA16 QACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 QACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHE 1080 1090 1100 1110 1120 1130 1040 1050 1060 1070 1080 1090 KIAA16 TPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPED ::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 TPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMD 1140 1150 1160 1170 1180 1100 1110 1120 1130 1140 1150 KIAA16 VTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSP >>gi|73997574|ref|XP_534874.2| PREDICTED: similar to ple (1284 aa) initn: 4542 init1: 2558 opt: 4428 Z-score: 4438.0 bits: 833.3 E(): 0 Smith-Waterman score: 7081; 85.681% identity (89.416% similar) in 1285 aa overlap (2-1175:1-1284) 10 20 30 40 50 KIAA16 DMAADLNLEWI-SLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDL :::::::::: :::::::::::::::::::::::::::::::::::::::::::::.:: gi|739 MAADLNLEWICSLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSADL 10 20 30 40 50 60 70 80 90 100 110 KIAA16 PTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 PTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERP 60 70 80 90 100 110 120 130 140 150 160 170 KIAA16 ISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYK :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: gi|739 ISMINEASNYNMTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYK 120 130 140 150 160 170 180 190 200 210 220 230 KIAA16 QDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKA ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: gi|739 QDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIAMLTSEDHINRKYAFKA 180 190 200 210 220 230 240 250 260 270 280 290 KIAA16 AHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKR------VDKITSENAPTKETNN :::::::::::::::::::::::::::::::::::::: ::::::::::::: :: gi|739 AHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITSENAPTKEINN 240 250 260 270 280 290 300 310 320 330 340 350 KIAA16 IPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSE .::::::::::.::::::::.:: :::::::::::::::::::::::::::::::::::: gi|739 FPNHRVLIKPEVQNNQKNKEISKTEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSE 300 310 320 330 340 350 360 370 380 390 400 410 KIAA16 YESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQ :::::.::::. ::::.:..::::::::::::::::::.::::::..::::::::::::: gi|739 YESGSTCPAQAGHYRPVNVNSSENKIVNVSLADLRGGNHPNTGPLHAEADRVIQRTNSMQ 360 370 380 390 400 410 420 430 440 450 460 470 KIAA16 QLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESI :::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::: gi|739 QLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQVMARYPEGYRTLPRNSKTRPESI 420 430 440 450 460 470 480 490 500 510 520 530 KIAA16 CSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVN ::::::::::::: ::::::::::::::::::::::::::::::::::::::.::::::: gi|739 CSVTPSTHDKTLGTGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLTSPKTMVN 480 490 500 510 520 530 540 550 560 570 580 590 KIAA16 ISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 ISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVP 540 550 560 570 580 590 600 610 620 630 640 650 KIAA16 DRRSVPAGLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAH ::::.::::::::.:::::::::::::::::::::::::::::.:::::::::::::::: gi|739 DRRSMPAGLTLQSISPQSLQGKTPEELTLLLIKLRRQQAELSSVREHTLAQLMQLKLEAH 600 610 620 630 640 650 660 670 KIAA16 SPKNEILSHHLQRNTIYLDHQ--------------------------------------- :::::::::::::::.::::: gi|739 SPKNEILSHHLQRNTMYLDHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKNKISLYC 660 670 680 690 700 710 680 690 700 710 720 730 KIAA16 LSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQ ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 LSQDECRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQ 720 730 740 750 760 770 740 750 760 770 780 790 KIAA16 EIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQ ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 EIEMNADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQ 780 790 800 810 820 830 800 810 820 830 840 850 KIAA16 MQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTV ::::::.::::::::::::::::::::::::::::::::::::::::: :: :::::::: gi|739 MQEQLDRLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTETGMAGSKPFSTV 840 850 860 870 880 890 KIAA16 KYKNE------------------------------------------------------- ::::: gi|739 KYKNEEEEVAPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKIHQVQG 900 910 920 930 940 950 860 870 880 890 900 910 KIAA16 --------GPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPR :::::::::::::::::::::::::::::::::::::: ::::::::::::: gi|739 YPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSV-KGSHFPVGVVPPR 960 970 980 990 1000 1010 920 930 940 950 960 970 KIAA16 AKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRH .:::::::::::::::::::::::: :::::::::.:::::::::::::::::::::::: gi|739 TKSPTPESSTIASYVTLRKTKKMMDSRTERPRSAVDQLCLAESTRPRMTVEEQMERIRRH 1020 1030 1040 1050 1060 1070 980 990 1000 1010 1020 KIAA16 QQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDD--KELDTAIRENDVKP ::::::::::::::::: ::::::::: :::::::::: ::::: :::::..::::::: gi|739 QQACLREKKKGLNVIGALDQSPLQSPSVLRDNPFRTTQPRRRDDNIKELDTVVRENDVKP 1080 1090 1100 1110 1120 1130 1030 1040 1050 1060 1070 1080 KIAA16 DHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKM .:::::.:::::::.::::.:::::.::::.: . ::.::::::.: ::.::: :..:: gi|739 NHETPAAEIVQLKEAEPQNMDFSKEFKKTEDIFSKTLFKPEPNGVSSEEMIDKEGNQEKM 1140 1150 1160 1170 1180 1190 1090 1100 1110 1120 1130 1140 KIAA16 PEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLS ::::. ::::::: ::: : ::::: :... :::::..:::.:::.:: .::::::::: gi|739 PEDVSCSPQDETQIINHKAESHPEENIKDNIHEQEETIVSYEQTPEASRESQTMAVKSLS 1200 1210 1220 1230 1240 1250 1150 1160 1170 KIAA16 PSPESSASPVPSTQPQLTEGSHFMCV :::::::::::.:::::::::::::: gi|739 PSPESSASPVPATQPQLTEGSHFMCV 1260 1270 1280 >>gi|149049101|gb|EDM01555.1| pleckstrin homology domain (1049 aa) initn: 4128 init1: 2341 opt: 4306 Z-score: 4316.8 bits: 810.6 E(): 0 Smith-Waterman score: 5209; 74.506% identity (83.214% similar) in 1114 aa overlap (110-1157:1-1049) 80 90 100 110 120 130 KIAA16 ERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHP :::::::::::::::::::::..:::.::: gi|149 MTSEEKKERPISMINEASNYNMASDYTVHP 10 20 30 140 150 160 170 180 190 KIAA16 MSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 MSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLC 40 50 60 70 80 90 200 210 220 230 240 250 KIAA16 LFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMEL ::::::::::::::::::::::::.::.:::::::::::::::::::::::::::::::: gi|149 LFYYRDEKEEGILGSILLPSFQIAMLTAEDHINRKYAFKAAHPNMRTYYFCTDTGKEMEL 100 110 120 130 140 150 260 270 280 290 300 310 KIAA16 WMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEE :::::::::::::::::::::::.:.: ::::::::::::::.::.::::::::.::::: gi|149 WMKAMLDAALVQTEPVKRVDKITTESASTKETNNIPNHRVLIRPEVQNNQKNKEISKIEE 160 170 180 190 200 210 320 330 340 350 360 370 KIAA16 KKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKI :.:::::.:::::::::::::::::::::::::::::: ::: :..::::::...:..: gi|149 KRALEAERYGFQKDGQDRPLTKINSVKLNSLPSEYESGPACPPQNIHYRPINVNNSDSKA 220 230 240 250 260 270 380 390 400 410 420 430 KIAA16 VNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQT :::::::.:::..:::::: :::::::::::::::::::::.::::: ::: :::::::: gi|149 VNVSLADVRGGSHPNTGPLATEADRVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQT 280 290 300 310 320 330 440 450 460 470 480 490 KIAA16 LPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDD ::::::::::::.::::::::::::::::::::::::::: :.:: :::::::::::::: gi|149 LPRNMPSHRAQILARYPEGYRTLPRNSKTRPESICSVTPSGHEKT-GPGAEEKRRSMRDD 340 350 360 370 380 500 510 520 530 540 550 KIAA16 TMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSP ::::::::::::::.::::::::: :::::.: ..:::::::::::::: :::::.:: gi|149 TMWQLYEWQQRQFYHKQSTLPRHSCLSSPKAMGKVSDQTMHSIPTSPSHVPAAAYQGFSP 390 400 410 420 430 440 560 570 580 590 600 610 KIAA16 QRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEE :::::::::::::::::::::::: :::::::::::::.::::.::.::::::.:.: gi|149 QRTYRSEVSSPIQRGDVTIDRRHRPHHPKHVYVPDRRSMPAGLALQAVSPQSLHGRT--- 450 460 470 480 490 500 620 630 640 650 660 670 KIAA16 LTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQLSQDE ::::: gi|149 -------------------------------------------------------LSQDE 510 680 690 700 710 720 730 KIAA16 GRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMH ::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::. gi|149 CRGTLYKYRPEEVDIDAKLSRLCEQDKVVRALEEKLQQLHKEKYTLEQALLSASQEIEMN 520 530 540 550 560 570 740 750 760 770 780 790 KIAA16 ADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: gi|149 ADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQDQL 580 590 600 610 620 630 800 810 820 830 840 850 KIAA16 DHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNE :.:::::.::::::::::::::::::::::::::::::::..: :. : ::: .::::.: gi|149 DRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSETGLAGPKPFPAVKYKSE 640 650 660 670 680 690 KIAA16 ------------------------------------------------------------ gi|149 EEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKSHQVQGYPRNG 700 710 720 730 740 750 860 870 880 890 900 910 KIAA16 ---GPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPT ::::::::::::::::::::::::::::::.:: :. ::.:::::::: : :.:::: gi|149 SHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPASEAEAPVVRGSHFPVGV-PLRTKSPT 760 770 780 790 800 810 920 930 940 950 960 970 KIAA16 PESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACL ::::::::::::::::::..::::::::::::::::::::::::::::.::::::::::: gi|149 PESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESTRPRMTVEEQLERIRRHQQACL 820 830 840 850 860 870 980 990 1000 1010 1020 1030 KIAA16 REKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDD--KELDTAIRENDVKPDHETP :::::::::..::: :: ::::..::.: :. :: :::: ::::.. :::: :::..: gi|149 REKKKGLNVLSASDPSPSQSPSSVRDSPSRVPQTVRRDDNTKELDAVHRENDGKPDYDTS 880 890 900 910 920 930 1040 1050 1060 1070 1080 1090 KIAA16 ATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEP-NGVNSVEMMDKERNKDKMPEDV :.: .. .:.:::..: ...::.::.: ::::. ::: ::..: :.: :::.....:: . gi|149 AAETAHPEEAEPQSADVGRKLKRTESIFYEMLYTPEPLNGLTSEEVMAKERQEEQVPEGA 940 950 960 970 980 990 1100 1110 1120 1130 1140 1150 KIAA16 TFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPE . : :.:. :::. : ::: .:. :.::.. : : .::. : ::: :. :: : gi|149 VCSLQEEAAMANHQAEGPPEEA--ESLHEEEEALASCEPAPETPRENQTTAA---LPSVE 1000 1010 1020 1030 1040 1160 1170 KIAA16 SSASPVPSTQPQLTEGSHFMCV :. : gi|149 STQS >>gi|110835706|ref|NP_659169.3| phosphoinositol 3-phosph (1269 aa) initn: 3922 init1: 1790 opt: 4224 Z-score: 4233.4 bits: 795.4 E(): 0 Smith-Waterman score: 6382; 78.132% identity (85.992% similar) in 1285 aa overlap (2-1175:1-1269) 10 20 30 40 50 KIAA16 DMAADLNLEWI-SLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDL :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: gi|110 MAADLNLEWICSLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDL 10 20 30 40 50 60 70 80 90 100 110 KIAA16 PTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERP ::::::::::::::::::::::::::::::::::::::::::::.:::::::::.::::: gi|110 PTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNDQTVATMTSEDKKERP 60 70 80 90 100 110 120 130 140 150 160 170 KIAA16 ISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYK :::::::::::..::::::::::::::::::::::::::::::::::::::::::::::: gi|110 ISMINEASNYNMASDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYK 120 130 140 150 160 170 180 190 200 210 220 230 KIAA16 QDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKA ::::::::::::::::::::::::::::::::::::::::::::.::.:::::::::::: gi|110 QDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIAMLTAEDHINRKYAFKA 180 190 200 210 220 230 240 250 260 270 280 290 KIAA16 AHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKR------VDKITSENAPTKETNN :::::::::::::::::::::::::::::::::::::: :::::...: :::::: gi|110 AHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITTDSASTKETNN 240 250 260 270 280 290 300 310 320 330 340 350 KIAA16 IPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSE ::::::::.::.::.:::::.::::::.:::::.::::::::::::::::::::::: :: gi|110 IPNHRVLIRPEVQNHQKNKEISKIEEKRALEAERYGFQKDGQDRPLTKINSVKLNSLLSE 300 310 320 330 340 350 360 370 380 390 400 410 KIAA16 YESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQ :::: :: :.:::::::..::..: :::::::.:::..::.::: :::::::::::::: gi|110 YESGPDCPPQNVHYRPINVNSSDGKAVNVSLADVRGGSHPNAGPLATEADRVIQRTNSMQ 360 370 380 390 400 410 420 430 440 450 460 470 KIAA16 QLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESI :::::::.::::: ::: ::::::::::::::::::::.:: :::::::::::::::::: gi|110 QLEQWIKVQKGRGLEEEPRGVISYQTLPRNMPSHRAQILARCPEGYRTLPRNSKTRPESI 420 430 440 450 460 470 480 490 500 510 520 530 KIAA16 CSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVN :::: : :.:: ::::::::::::::::::::::::::::.::::::::. :::::.::. gi|110 CSVTSSGHEKT-GPGAEEKRRSMRDDTMWQLYEWQQRQFYHKQSTLPRHGCLSSPKAMVQ 480 490 500 510 520 530 540 550 560 570 580 590 KIAA16 ISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVP .:::::::::::::::: :::::.::::::::::.::::::::::::::: :::::::: gi|110 VSDQTMHSIPTSPSHGSAAAYQGFSPQRTYRSEVTSPIQRGDVTIDRRHRPHHPKHVYVA 540 550 560 570 580 590 600 610 620 630 640 650 KIAA16 DRRSVPAGLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAH ::::.:::::::.::::::::.:::::::::::::::::::::.:::::::::::::::: gi|110 DRRSMPAGLTLQAVSPQSLQGRTPEELTLLLIKLRRQQAELSSVREHTLAQLMQLKLEAH 600 610 620 630 640 650 660 670 KIAA16 SPKNEILSHHLQRNTIYLDHQ--------------------------------------- ::::::::::::::::::::: gi|110 SPKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKNKISLYC 660 670 680 690 700 710 680 690 700 710 720 730 KIAA16 LSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQ ::::: :::::::::::. :::::::::::::::.::::::::::::::::::::::::: gi|110 LSQDECRGTLYKYRPEEAGIDAKLSRLCEQDKVVRALEEKLQQLHKEKYTLEQALLSASQ 720 730 740 750 760 770 740 750 760 770 780 790 KIAA16 EIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQ ::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::.: gi|110 EIEMNADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRDQ 780 790 800 810 820 830 800 810 820 830 840 850 KIAA16 MQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTV :: :::.:::::.::::::::::::::::::::::::::::::::..: :. ::::::.: gi|110 MQGQLDRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSETGLAGSKPFSSV 840 850 860 870 880 890 KIAA16 KYKNE------------------------------------------------------- :::.: gi|110 KYKSEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEDKKIHQVQG 900 910 920 930 940 950 860 870 880 890 900 910 KIAA16 --------GPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPR ::::::::::::::::::::::::::::::::: :. ::::::::::: : : gi|110 YPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSETEAPVVKGSHFPVGV-PLR 960 970 980 990 1000 1010 920 930 940 950 960 970 KIAA16 AKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRH .::::::::::::::::::::::..::::::::::::::::::.:::::::::.:::::: gi|110 TKSPTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLERIRRH 1020 1030 1040 1050 1060 1070 980 990 1000 1010 1020 KIAA16 QQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDD--KELDTAIRENDVKP ::::::::::::.:.:::: ::..::.:.: ::: :::: :::::. ::::::: gi|110 QQACLREKKKGLSVLGASD------PSDVRDSPLRLTQTLRRDDNVKELDTVHRENDVKP 1080 1090 1100 1110 1120 1130 1030 1040 1050 1060 1070 1080 KIAA16 DHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKM :.::::.. ..:...::::.:....::..: ::. :::::. : :. .:::.:... gi|110 DYETPAAQCAHLEDAEPQNADIGRKLKRSE-----MLYTPEPNGMASEEVTEKERQKEQV 1140 1150 1160 1170 1180 1090 1100 1110 1120 1130 1140 KIAA16 PEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLS : . :::.:: ..:. : ::: .:. :.:::. : : .::. : ::: .:.::: gi|110 HADGSCSPQEETAMTEHQMEGPPEE--AESLHEEEETLASCEPAPEIPRENQT-TVRSLS 1190 1200 1210 1220 1230 1240 1150 1160 1170 KIAA16 PSPESSASPVPSTQPQLTEGSHFMCV :::.::.. : : ::: :::::::: gi|110 PSPDSSTAADPPTPPQLREGSHFMCV 1250 1260 1175 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Thu Mar 5 11:33:42 2009 done: Thu Mar 5 11:37:33 2009 Total Scan time: 1776.710 Total Display time: 1.040 Function used was FASTA [version 34.26.5 April 26, 2007]