# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/hh15184.fasta.nr -Q ../query/KIAA1625.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1625, 859 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7822579 sequences Expectation_n fit: rho(ln(x))= 5.4217+/-0.000188; mu= 13.4609+/- 0.011 mean_var=88.4578+/-17.146, 0's: 43 Z-trim: 71 B-trim: 0 in 0/65 Lambda= 0.136366 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|17865625|sp|Q9HCE7.2|SMUF1_HUMAN RecName: Full= ( 757) 5212 1035.8 0 gi|114614808|ref|XP_528043.2| PREDICTED: Smad ubiq ( 794) 5105 1014.8 0 gi|119597092|gb|EAW76686.1| SMAD specific E3 ubiqu ( 582) 4021 801.4 0 gi|149635098|ref|XP_001510726.1| PREDICTED: hypoth ( 748) 3563 711.4 3.6e-202 gi|114670061|ref|XP_511577.2| PREDICTED: SMAD spec (1009) 3553 709.5 1.7e-201 gi|218547425|sp|A2A5Z6.1|SMUF2_MOUSE RecName: Full ( 748) 3551 709.0 1.8e-201 gi|149054600|gb|EDM06417.1| SMAD specific E3 ubiqu ( 748) 3541 707.1 7.2e-201 gi|12018151|gb|AAG45422.1| E3 ubiquitin ligase SMU ( 748) 3540 706.9 8.2e-201 gi|17865624|sp|Q9HAU4.1|SMUF2_HUMAN RecName: Full= ( 748) 3539 706.7 9.4e-201 gi|56407185|gb|AAV87906.1| E3 ubiquitin ligase SMU ( 748) 3539 706.7 9.4e-201 gi|118099762|ref|XP_425380.2| PREDICTED: similar t ( 753) 3528 704.5 4.2e-200 gi|123896339|sp|Q2TAS2.1|SMUF2_XENLA RecName: Full ( 751) 3495 698.0 3.8e-198 gi|109116811|ref|XP_001109913.1| PREDICTED: simila ( 898) 3489 696.9 9.9e-198 gi|194216751|ref|XP_001917141.1| PREDICTED: SMAD s ( 753) 3476 694.3 5.1e-197 gi|73965391|ref|XP_537589.2| PREDICTED: similar to ( 738) 3474 693.9 6.6e-197 gi|119912571|ref|XP_613331.3| PREDICTED: similar t ( 904) 3452 689.6 1.5e-195 gi|123241747|emb|CAM16224.1| SMAD specific E3 ubiq ( 735) 3382 675.8 1.8e-191 gi|119614601|gb|EAW94195.1| SMAD specific E3 ubiqu ( 735) 3370 673.4 9.5e-191 gi|126308844|ref|XP_001379303.1| PREDICTED: hypoth ( 848) 3364 672.3 2.4e-190 gi|210131071|gb|EEA78741.1| hypothetical protein B ( 762) 3237 647.3 7.3e-183 gi|3694664|gb|AAC62434.1| similar to NEDD-4 (KIA00 ( 712) 3194 638.8 2.5e-180 gi|6446606|gb|AAF08298.2| E3 ubiquitin ligase SMUR ( 722) 3194 638.8 2.5e-180 gi|51094634|gb|EAL23886.1| E3 ubiquitin ligase SMU ( 731) 3194 638.8 2.5e-180 gi|194218685|ref|XP_001494592.2| PREDICTED: SMAD s ( 722) 3186 637.2 7.4e-180 gi|85681896|sp|Q9CUN6.2|SMUF1_MOUSE RecName: Full= ( 731) 3171 634.3 5.8e-179 gi|74181841|dbj|BAE32623.1| unnamed protein produc ( 731) 3161 632.3 2.3e-178 gi|194678687|ref|XP_591663.3| PREDICTED: similar t ( 837) 3150 630.2 1.1e-177 gi|73958097|ref|XP_851049.1| PREDICTED: similar to ( 740) 3146 629.3 1.8e-177 gi|219518262|gb|AAI44415.1| SMURF1 protein [Homo s ( 728) 3142 628.5 3e-177 gi|126334572|ref|XP_001369671.1| PREDICTED: simila ( 742) 3138 627.8 5.3e-177 gi|148687064|gb|EDL19011.1| SMAD specific E3 ubiqu ( 710) 3137 627.6 5.8e-177 gi|20810398|gb|AAH29097.1| SMAD specific E3 ubiqui ( 728) 3137 627.6 5.9e-177 gi|87044886|ref|NP_083714.3| Smad ubiquitination r ( 728) 3137 627.6 5.9e-177 gi|149034904|gb|EDL89624.1| rCG42768 [Rattus norve ( 728) 3137 627.6 5.9e-177 gi|26381191|dbj|BAB29770.2| unnamed protein produc ( 553) 3133 626.7 8.4e-177 gi|149409162|ref|XP_001512326.1| PREDICTED: simila ( 750) 3130 626.2 1.6e-176 gi|118097811|ref|XP_414794.2| PREDICTED: similar t ( 729) 3106 621.5 4.1e-175 gi|198435628|ref|XP_002127387.1| PREDICTED: simila ( 758) 3106 621.5 4.2e-175 gi|17865628|sp|Q9PUN2.1|SMUF1_XENLA RecName: Full= ( 731) 2980 596.7 1.2e-167 gi|37590632|gb|AAH59201.1| WW domain containing E3 ( 731) 2936 588.0 4.8e-165 gi|47223927|emb|CAG06104.1| unnamed protein produc ( 734) 2760 553.4 1.3e-154 gi|119614600|gb|EAW94194.1| SMAD specific E3 ubiqu ( 507) 2629 527.5 5.5e-147 gi|218547424|sp|A9JRZ0.1|SMUF2_DANRE RecName: Full ( 765) 2537 509.5 2.1e-141 gi|26330149|dbj|BAC28813.1| unnamed protein produc ( 355) 2416 485.4 1.7e-134 gi|110760799|ref|XP_396318.3| PREDICTED: similar t ( 779) 2259 454.9 6.2e-125 gi|75765918|pdb|1ZVD|A Chain A, Regulation Of Smur ( 380) 2248 452.4 1.6e-124 gi|47209050|emb|CAF92291.1| unnamed protein produc ( 774) 2229 449.0 3.7e-123 gi|119597095|gb|EAW76689.1| SMAD specific E3 ubiqu ( 581) 2156 434.5 6.3e-119 gi|156549821|ref|XP_001606601.1| PREDICTED: simila ( 905) 2059 415.6 4.9e-113 gi|193911060|gb|EDW09927.1| GI18790 [Drosophila mo (1087) 2017 407.4 1.7e-110 >>gi|17865625|sp|Q9HCE7.2|SMUF1_HUMAN RecName: Full=E3 u (757 aa) initn: 5212 init1: 5212 opt: 5212 Z-score: 5539.1 bits: 1035.8 E(): 0 Smith-Waterman score: 5212; 100.000% identity (100.000% similar) in 757 aa overlap (103-859:1-757) 80 90 100 110 120 130 KIAA16 VTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRLTVLCAKNLAKKDF :::::::::::::::::::::::::::::: gi|178 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDF 10 20 30 140 150 160 170 180 190 KIAA16 FRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 FRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQ 40 50 60 70 80 90 200 210 220 230 240 250 KIAA16 GAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 GAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVV 100 110 120 130 140 150 260 270 280 290 300 310 KIAA16 DCRGLLENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 DCRGLLENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQ 160 170 180 190 200 210 320 330 340 350 360 370 KIAA16 RLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 RLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSP 220 230 240 250 260 270 380 390 400 410 420 430 KIAA16 SGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 SGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNR 280 290 300 310 320 330 440 450 460 470 480 490 KIAA16 TTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 TTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELS 340 350 360 370 380 390 500 510 520 530 540 550 KIAA16 LQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 LQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYL 400 410 420 430 440 450 560 570 580 590 600 610 KIAA16 LCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 LCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGF 460 470 480 490 500 510 620 630 640 650 660 670 KIAA16 TVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 TVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHEL 520 530 540 550 560 570 680 690 700 710 720 730 KIAA16 KPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 KPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELEL 580 590 600 610 620 630 740 750 760 770 780 790 KIAA16 IIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 IIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQ 640 650 660 670 680 690 800 810 820 830 840 850 KIAA16 GFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|178 GFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE 700 710 720 730 740 750 KIAA16 TCGFAVE ::::::: gi|178 TCGFAVE >>gi|114614808|ref|XP_528043.2| PREDICTED: Smad ubiquiti (794 aa) initn: 5105 init1: 5105 opt: 5105 Z-score: 5425.0 bits: 1014.8 E(): 0 Smith-Waterman score: 5105; 99.596% identity (99.865% similar) in 743 aa overlap (117-859:52-794) 90 100 110 120 130 140 KIAA16 WGAVALDPRLPDRWREMSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDG .: :.::::::::::::::::::::::::: gi|114 LTAEENYTVDSHYSQDYSELRQSSLVNAQTLRETLLCAKNLAKKDFFRLPDPFAKIVVDG 30 40 50 60 70 80 150 160 170 180 190 200 KIAA16 SGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNA 90 100 110 120 130 140 210 220 230 240 250 260 KIAA16 ISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYE 150 160 170 180 190 200 270 280 290 300 310 320 KIAA16 DSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTP 210 220 230 240 250 260 330 340 350 360 370 380 KIAA16 QNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYE 270 280 290 300 310 320 390 400 410 420 430 440 KIAA16 FLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMN 330 340 350 360 370 380 450 460 470 480 490 500 KIAA16 HQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 HQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVS 390 400 410 420 430 440 510 520 530 540 550 560 KIAA16 REEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 REEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQ 450 460 470 480 490 500 570 580 590 600 610 620 KIAA16 YSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 YSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQ 510 520 530 540 550 560 630 640 650 660 670 680 KIAA16 LSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENK 570 580 590 600 610 620 690 700 710 720 730 740 KIAA16 KEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWK 630 640 650 660 670 680 750 760 770 780 790 800 KIAA16 SNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGP 690 700 710 720 730 740 810 820 830 840 850 KIAA16 RLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE ::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 RLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 750 760 770 780 790 >>gi|119597092|gb|EAW76686.1| SMAD specific E3 ubiquitin (582 aa) initn: 4021 init1: 4021 opt: 4021 Z-score: 4274.3 bits: 801.4 E(): 0 Smith-Waterman score: 4021; 100.000% identity (100.000% similar) in 582 aa overlap (278-859:1-582) 250 260 270 280 290 300 KIAA16 GGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQ :::::::::::::::::::::::::::::: gi|119 MEEPAPYTDSTGAAAGGGNCRFVESPSQDQ 10 20 30 310 320 330 340 350 360 KIAA16 RLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDP 40 50 60 70 80 90 370 380 390 400 410 420 KIAA16 RIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFV 100 110 120 130 140 150 430 440 450 460 470 480 KIAA16 DHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVL 160 170 180 190 200 210 490 500 510 520 530 540 KIAA16 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAR 220 230 240 250 260 270 550 560 570 580 590 600 KIAA16 EWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 EWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHY 280 290 300 310 320 330 610 620 630 640 650 660 KIAA16 INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRI 340 350 360 370 380 390 670 680 690 700 710 720 KIAA16 LQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQ 400 410 420 430 440 450 730 740 750 760 770 780 KIAA16 KELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGST 460 470 480 490 500 510 790 800 810 820 830 840 KIAA16 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 520 530 540 550 560 570 850 KIAA16 TAVEETCGFAVE :::::::::::: gi|119 TAVEETCGFAVE 580 >>gi|149635098|ref|XP_001510726.1| PREDICTED: hypothetic (748 aa) initn: 3292 init1: 1997 opt: 3563 Z-score: 3785.9 bits: 711.4 E(): 3.6e-202 Smith-Waterman score: 3839; 72.854% identity (83.460% similar) in 792 aa overlap (103-859:1-748) 80 90 100 110 120 130 KIAA16 VTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRLTVLCAKNLAKKDF ::::: :::: .:.::::::::::.:::: gi|149 MSNPGGRRNGP-VKLRLTVLCAKNLVKKDF 10 20 140 150 160 170 180 190 KIAA16 FRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQ :::::::::.:::::::::::::::::::::::::::::.::.::.:::::::::::::: gi|149 FRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQ 30 40 50 60 70 80 200 210 220 230 240 250 KIAA16 GAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVV :::::::::::::::.:::::::::::::::.:.:.:.::::::::::.::::::::.:: gi|149 GAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVV 90 100 110 120 130 140 260 270 280 KIAA16 DCRGLLENE------------GTVY-------------------EDSGPGRPLSCFMEEP :: :..:. : . : :.::::::::..: gi|149 DCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDEN 150 160 170 180 190 200 290 300 310 320 330 340 KIAA16 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEG .: : ..::..: :.: :: .:.:. :. . .: : : :.:::: gi|149 TPITGTNGATSG---------QSSDPRLAERRVRSQRHRNYM----SRTHLHTPPDLPEG 210 220 230 240 250 350 360 370 380 390 400 KIAA16 YEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNS :::::: ::::::::::::::::::::.: :::.. gi|149 YEQRTTQQGQVYFLHTQTGVSTWHDPRVP--------------------------RDLSN 260 270 280 290 410 420 430 440 450 KIAA16 VNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----HHIMNHQCQLKEPSQP .::.::::::::::.:.:..::.::::::::::::::::: : ..:.: :::. .: gi|149 INCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQ 300 310 320 330 340 350 460 470 480 490 500 510 KIAA16 LPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQ : : : : : . ::.::::::::.::.::: :::::::::::::::::::::::: gi|149 -QLVSLCPDEAECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQ 360 370 380 390 400 520 530 540 550 560 570 KIAA16 IMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQI .:::::::: ::::.::::::::::::::::::::: :::::::::::::: :.:: ::: gi|149 VMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQI 410 420 430 440 450 460 580 590 600 610 620 630 KIAA16 NPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPEL ::::..::.:::::::::::::.::::::::.::::.::::::::::: :.:.: :::.: gi|149 NPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLDDMELVDPDL 470 480 490 500 510 520 640 650 660 670 680 690 KIAA16 HKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWR :.::::::::::: ::::::::::::.:.:.::::::::...:::::::::::::::::: gi|149 HNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWR 530 540 550 560 570 580 700 710 720 730 740 750 KIAA16 FMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVAD :.::::::::::::::::.::::::: ::.::::::: :: :::..::: :::::::. : gi|149 FLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPD 590 600 610 620 630 640 760 770 780 790 800 810 KIAA16 SNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDAN ::::.:::.::: ::::::::::::::::.:::::::::::: :::::::::: :::. gi|149 SNIVKWFWKAVELFDEERRARLLQFVTGSSRVPLQGFKALQG---AAGPRLFTIHQIDAS 650 660 670 680 690 700 820 830 840 850 KIAA16 TDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE :.::::::::::::::::::::::::::::::.::::::::: gi|149 TNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 710 720 730 740 >>gi|114670061|ref|XP_511577.2| PREDICTED: SMAD specific (1009 aa) initn: 3273 init1: 1983 opt: 3553 Z-score: 3773.5 bits: 709.5 E(): 1.7e-201 Smith-Waterman score: 3830; 68.439% identity (79.422% similar) in 865 aa overlap (33-859:204-1009) 10 20 30 40 50 KIAA16 RKRRGRRASGSEVVEAAEAAAARDWARLEAARVRAPQQAPISRLDH---PPAARTPGPRS :: ::. : . : :::. . .: . gi|114 GGAGGGGAGGRGCRFVVRPGPRKEKWEEGGARRPAPSAAHGDDSRHIRDPPAVAAAAPAA 180 190 200 210 220 230 60 70 80 90 100 110 KIAA16 LCPGSDPGAQPGAVTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRL :. :.::. : ::: : .::::: :::: .:.:: gi|114 RAPA------PAAVVT---------PPRLAVAPVPPAAPAAGDMSNPGGRRNGP-VKLRL 240 250 260 270 120 130 140 150 160 170 KIAA16 TVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSIT ::::::::.:::::::::::::.:::::::::::::::::::::::::::::.::.::.: gi|114 TVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVT 280 290 300 310 320 330 180 190 200 210 220 230 KIAA16 ISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSL ::::::::::::::::::::::::::::.:::::::::::::::.:.:.:.::::::::: gi|114 ISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSL 340 350 360 370 380 390 240 250 260 KIAA16 QTRDRIGTGGSVVDCRGLLENE------------GTVY-------------------EDS :.::::::::.:::: :..:. : . : : gi|114 QSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYS 400 410 420 430 440 450 270 280 290 300 310 320 KIAA16 GPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQN .::::::::..: .: . ..::. : :.: :: .:.:. :. . . gi|114 SPGRPLSCFVDENTPISGTNGATCG---------QSSDPRLAERRVRSQRHRNYM----S 460 470 480 490 500 330 340 350 360 370 380 KIAA16 RPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFL : : : :.:::::::::: ::::::::::::::::::::.: gi|114 RTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP------------------ 510 520 530 540 390 400 410 420 430 440 KIAA16 LQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----HHI :::...::.::::::::::.:.:..::.::::::::::::::::: : . gi|114 --------RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLV 550 560 570 580 590 450 460 470 480 490 500 KIAA16 MNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIE .:.: :::. .: . : . : : . ::.::::::::.::.::: ::::::::::: gi|114 LNRQNQLKDQQQQ-QVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIE 600 610 620 630 640 650 510 520 530 540 550 560 KIAA16 VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGL :::::::::::::.:::::::: ::::.::::::::::::::::::::: :::::::::: gi|114 VSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGL 660 670 680 690 700 710 570 580 590 600 610 620 KIAA16 FQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP :::: :.:: :::::::..::.:::::::::::::.::::::::.::::.::::::::: gi|114 FQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS 720 730 740 750 760 770 630 640 650 660 670 680 KIAA16 IQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEE : :.:.: :::.::.::::::::::: ::::::::::::.:.:.::::::::...::.:: gi|114 ITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEE 780 790 800 810 820 830 690 700 710 720 730 740 KIAA16 NKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLND ::::::::::::::.::::::::::::::::.::::::: ::.::::::: :: :::.:: gi|114 NKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVND 840 850 860 870 880 890 750 760 770 780 790 800 KIAA16 WKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAA :: :::::::. :::::.:::.::: ::::::::::::::::.:::::::::::: :: gi|114 WKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQG---AA 900 910 920 930 940 950 810 820 830 840 850 KIAA16 GPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE :::::::: ::: :.::::::::::::::::::::::::::::::.::::::::: gi|114 GPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 960 970 980 990 1000 >>gi|218547425|sp|A2A5Z6.1|SMUF2_MOUSE RecName: Full=E3 (748 aa) initn: 3274 init1: 1981 opt: 3551 Z-score: 3773.1 bits: 709.0 E(): 1.8e-201 Smith-Waterman score: 3820; 72.348% identity (83.207% similar) in 792 aa overlap (103-859:1-748) 80 90 100 110 120 130 KIAA16 VTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRLTVLCAKNLAKKDF ::::: :::: .:.::::::::::.:::: gi|218 MSNPGGRRNGP-VKLRLTVLCAKNLVKKDF 10 20 140 150 160 170 180 190 KIAA16 FRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQ :::::::::.:::::::::::::::::::::::::::::.::.::.:::::::::::::: gi|218 FRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQ 30 40 50 60 70 80 200 210 220 230 240 250 KIAA16 GAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVV :::::::::::::::.:::::::::::::::.:.:.:.::::::::::.::::::::.:: gi|218 GAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVV 90 100 110 120 130 140 260 270 280 KIAA16 DCRGLLENE------------GTVY-------------------EDSGPGRPLSCFMEEP :: :..:. : . : :.::::::::..: gi|218 DCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDEN 150 160 170 180 190 200 290 300 310 320 330 340 KIAA16 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEG .: : ..::. : :.: :: .:.:. :. . .: : : :.:::: gi|218 TPITGTNGATCG---------HSSDPRLAERRVRSQRHRNYM----SRTHLHTPPDLPEG 210 220 230 240 250 350 360 370 380 390 400 KIAA16 YEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNS :::::: ::::::::::::::::::::.: :::.. gi|218 YEQRTTQQGQVYFLHTQTGVSTWHDPRVP--------------------------RDLSN 260 270 280 290 410 420 430 440 450 KIAA16 VNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----HHIMNHQCQLKEPSQP .::.::::::::::.:.:..::.::::::::::::::::: : ..:.: :::. .: gi|218 INCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQ 300 310 320 330 340 350 460 470 480 490 500 510 KIAA16 LPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQ .: . . : : . ::.::::::::.::.::: :::::::::::::::::::::::: gi|218 QVVPLCPD-DTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQ 360 370 380 390 400 520 530 540 550 560 570 KIAA16 IMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQI .:::::::: ::::.::::::::::::::::::::: :::::::::::::: :.:: ::: gi|218 VMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQI 410 420 430 440 450 460 580 590 600 610 620 630 KIAA16 NPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPEL ::::..::.:::::::::::::.::::::::.::::.::::::::: : :.:.: :::.: gi|218 NPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDL 470 480 490 500 510 520 640 650 660 670 680 690 KIAA16 HKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWR :.::::::::::: ::::::::::::.:.:.::::::::...:::::::::::::::::: gi|218 HNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWR 530 540 550 560 570 580 700 710 720 730 740 750 KIAA16 FMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVAD :.::::::::::::::::.::::::: ::.::::::: :: :::..::: :::::::. : gi|218 FLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPD 590 600 610 620 630 640 760 770 780 790 800 810 KIAA16 SNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDAN ::.:.:::.::: ::::::::::::::::.:::::::::::: :::::::::: ::: gi|218 SNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQG---AAGPRLFTIHQIDAC 650 660 670 680 690 700 820 830 840 850 KIAA16 TDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE :.::::::::::::::::::::::::::::::.::::::::: gi|218 TNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 710 720 730 740 >>gi|149054600|gb|EDM06417.1| SMAD specific E3 ubiquitin (748 aa) initn: 3278 init1: 1985 opt: 3541 Z-score: 3762.5 bits: 707.1 E(): 7.2e-201 Smith-Waterman score: 3818; 72.348% identity (83.207% similar) in 792 aa overlap (103-859:1-748) 80 90 100 110 120 130 KIAA16 VTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRLTVLCAKNLAKKDF ::::: :::: .:.::::::::::.:::: gi|149 MSNPGGRRNGP-VKLRLTVLCAKNLVKKDF 10 20 140 150 160 170 180 190 KIAA16 FRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQ :::::::::.:::::::::::::::::::::::::::::.::.::.:::::::::::::: gi|149 FRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQ 30 40 50 60 70 80 200 210 220 230 240 250 KIAA16 GAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVV :::::::::::::::.:::::::::::::::.:.:.:.::::::::::.::::::::.:: gi|149 GAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVV 90 100 110 120 130 140 260 270 280 KIAA16 DCRGLLENE------------GTVY-------------------EDSGPGRPLSCFMEEP :: :..:. : . : :.::::::::..: gi|149 DCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDEN 150 160 170 180 190 200 290 300 310 320 330 340 KIAA16 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEG .: : ..::. : :.: :: .:.:. :. . .: : : :.:::: gi|149 TPITGTNGATCG---------QSSDPRLAERRVRSQRHRNYM----SRTHLHTPPDLPEG 210 220 230 240 250 350 360 370 380 390 400 KIAA16 YEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNS :::::: ::::::::::::::::::::.: :::.. gi|149 YEQRTTQQGQVYFLHTQTGVSTWHDPRVP--------------------------RDLSN 260 270 280 290 410 420 430 440 450 KIAA16 VNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----HHIMNHQCQLKEPSQP .::.::::::::::.:.:..::.::::::::::::::::: : ..:.: :::. .: gi|149 INCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQ 300 310 320 330 340 350 460 470 480 490 500 510 KIAA16 LPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQ . : . : : . ::.::::::::.::.::: :::::::::::::::::::::::: gi|149 -QVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQ 360 370 380 390 400 520 530 540 550 560 570 KIAA16 IMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQI .:::::::: ::::.::::::::::::::::::::: :::::::::::::: :.:: ::: gi|149 VMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQI 410 420 430 440 450 460 580 590 600 610 620 630 KIAA16 NPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPEL ::::..::.:::::::::::::.::::::::.::::.::::::::: : :.:.: :::.: gi|149 NPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDL 470 480 490 500 510 520 640 650 660 670 680 690 KIAA16 HKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWR :.::::::::::: ::::::::::::.:.:.::::::::...:::::::::::::::::: gi|149 HNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWR 530 540 550 560 570 580 700 710 720 730 740 750 KIAA16 FMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVAD :.::::::::::::::::.::::::: ::.::::::: :: :::..:::.:::::::. : gi|149 FLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKANTRLKHCTPD 590 600 610 620 630 640 760 770 780 790 800 810 KIAA16 SNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDAN ::.:.:::.::: ::::::::::::::::.:::::::::::: :::::::::: ::: gi|149 SNVVKWFWKAVELFDEERRARLLQFVTGSSRVPLQGFKALQG---AAGPRLFTIHQIDAC 650 660 670 680 690 700 820 830 840 850 KIAA16 TDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE :.::::::::::::::::::::::::::::::.::::::::: gi|149 TNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 710 720 730 740 >>gi|12018151|gb|AAG45422.1| E3 ubiquitin ligase SMURF2 (748 aa) initn: 3280 init1: 1983 opt: 3540 Z-score: 3761.4 bits: 706.9 E(): 8.2e-201 Smith-Waterman score: 3814; 72.348% identity (83.081% similar) in 792 aa overlap (103-859:1-748) 80 90 100 110 120 130 KIAA16 VTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRLTVLCAKNLAKKDF ::::: :::: .:.::::::::::.:::: gi|120 MSNPGRRRNGP-VKLRLTVLCAKNLVKKDF 10 20 140 150 160 170 180 190 KIAA16 FRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQ :::::::::.:::::::::::::::::::::::::::::.::.::.:::::::::::::: gi|120 FRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQ 30 40 50 60 70 80 200 210 220 230 240 250 KIAA16 GAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVV :::::::::::::::.:::::::::::::::.:.:.:.::::::::::.::::::::.:: gi|120 GAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVV 90 100 110 120 130 140 260 270 280 KIAA16 DCRGLLENE------------GTVY-------------------EDSGPGRPLSCFMEEP :: :..:. : . : :.::::::::..: gi|120 DCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDEN 150 160 170 180 190 200 290 300 310 320 330 340 KIAA16 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEG .: . ..::. : :.: :: .:.:. :. . .: : : :.:::: gi|120 TPISGTNGATCG---------QSSDPRLAERRVRSQRHRNYM----SRTHLHTPPDLPEG 210 220 230 240 250 350 360 370 380 390 400 KIAA16 YEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNS :::::: ::::::::::::::::::::.: :::.. gi|120 YEQRTTQQGQVYFLHTQTGVSTWHDPRVP--------------------------RDLSN 260 270 280 290 410 420 430 440 450 KIAA16 VNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----HHIMNHQCQLKEPSQP .::.::::::::::.:.:..::.::::::::::::::::: : ..:.: :::. .: gi|120 INCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQ 300 310 320 330 340 350 460 470 480 490 500 510 KIAA16 LPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQ . : . : : . ::.::::::::.::.::: :::::::::::::::::::::::: gi|120 -QVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQ 360 370 380 390 400 520 530 540 550 560 570 KIAA16 IMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQI .:::::::: ::::.::::::::::::::::::::: :::::::::::::: :.:: ::: gi|120 VMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQI 410 420 430 440 450 460 580 590 600 610 620 630 KIAA16 NPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPEL ::::..::.:::::::::::::.::::::::.::::.::::::::: : :.:.: :::.: gi|120 NPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDL 470 480 490 500 510 520 640 650 660 670 680 690 KIAA16 HKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWR :.::::::::::: ::::::::::::.:.:.::::::::...::.::::::::::::::: gi|120 HNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWR 530 540 550 560 570 580 700 710 720 730 740 750 KIAA16 FMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVAD :.::::::::::::::::.::::::: ::.::::::: :: :::.:::: :::::::. : gi|120 FLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPD 590 600 610 620 630 640 760 770 780 790 800 810 KIAA16 SNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDAN ::::.:::.::: ::::::::::::::::.:::::::::::: :::::::::: ::: gi|120 SNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQG---AAGPRLFTIHQIDAC 650 660 670 680 690 700 820 830 840 850 KIAA16 TDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE :.::::::::::::::::::::::::::::::.::::::::: gi|120 TNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 710 720 730 740 >>gi|17865624|sp|Q9HAU4.1|SMUF2_HUMAN RecName: Full=E3 u (748 aa) initn: 3273 init1: 1983 opt: 3539 Z-score: 3760.4 bits: 706.7 E(): 9.4e-201 Smith-Waterman score: 3813; 72.348% identity (83.081% similar) in 792 aa overlap (103-859:1-748) 80 90 100 110 120 130 KIAA16 VTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRLTVLCAKNLAKKDF ::::: :::: .:.::::::::::.:::: gi|178 MSNPGGRRNGP-VKLRLTVLCAKNLVKKDF 10 20 140 150 160 170 180 190 KIAA16 FRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQ :::::::::.:::::::::::::::::::::::::::::.::.::.:::::::::::::: gi|178 FRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQ 30 40 50 60 70 80 200 210 220 230 240 250 KIAA16 GAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVV :::::::::::::::.:::::::::::::::.:.:.:.::::::::::.::::::::.:: gi|178 GAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVV 90 100 110 120 130 140 260 270 280 KIAA16 DCRGLLENE------------GTVY-------------------EDSGPGRPLSCFMEEP :: :..:. : . : :.::::::::..: gi|178 DCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDEN 150 160 170 180 190 200 290 300 310 320 330 340 KIAA16 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEG .: . ..::. : :.: :: .:.:. :. . .: : : :.:::: gi|178 TPISGTNGATCG---------QSSDPRLAERRVRSQRHRNYM----SRTHLHTPPDLPEG 210 220 230 240 250 350 360 370 380 390 400 KIAA16 YEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNS :::::: ::::::::::::::::::::.: :::.. gi|178 YEQRTTQQGQVYFLHTQTGVSTWHDPRVP--------------------------RDLSN 260 270 280 290 410 420 430 440 450 KIAA16 VNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----HHIMNHQCQLKEPSQP .::.::::::::::.:.:..::.::::::::::::::::: : ..:.: :::. .: gi|178 INCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQ 300 310 320 330 340 350 460 470 480 490 500 510 KIAA16 LPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQ . : . : : . ::.::::::::.::.::: :::::::::::::::::::::::: gi|178 -QVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQ 360 370 380 390 400 520 530 540 550 560 570 KIAA16 IMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQI .:::::::: ::::.::::::::::::::::::::: :::::::::::::: :.:: ::: gi|178 VMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQI 410 420 430 440 450 460 580 590 600 610 620 630 KIAA16 NPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPEL ::::..::.:::::::::::::.::::::::.::::.::::::::: : :.:.: :::.: gi|178 NPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDL 470 480 490 500 510 520 640 650 660 670 680 690 KIAA16 HKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWR :.::::::::::: ::::::::::::.:.:.::::::::...::.::::::::::::::: gi|178 HNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWR 530 540 550 560 570 580 700 710 720 730 740 750 KIAA16 FMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVAD :.::::::::::::::::.::::::: ::.::::::: :: :::.:::: :::::::. : gi|178 FLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPD 590 600 610 620 630 640 760 770 780 790 800 810 KIAA16 SNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDAN ::::.:::.::: ::::::::::::::::.:::::::::::: :::::::::: ::: gi|178 SNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQG---AAGPRLFTIHQIDAC 650 660 670 680 690 700 820 830 840 850 KIAA16 TDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE :.::::::::::::::::::::::::::::::.::::::::: gi|178 TNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 710 720 730 740 >>gi|56407185|gb|AAV87906.1| E3 ubiquitin ligase SMURF2 (748 aa) initn: 3262 init1: 1981 opt: 3539 Z-score: 3760.4 bits: 706.7 E(): 9.4e-201 Smith-Waterman score: 3808; 72.222% identity (83.081% similar) in 792 aa overlap (103-859:1-748) 80 90 100 110 120 130 KIAA16 VTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRLTVLCAKNLAKKDF ::::: :::: .:.::::::::::.:::: gi|564 MSNPGGRRNGP-VKLRLTVLCAKNLVKKDF 10 20 140 150 160 170 180 190 KIAA16 FRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQ :::::::::.:::::::::::::::::::::::::::::.::.::.:::::::::::::: gi|564 FRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQ 30 40 50 60 70 80 200 210 220 230 240 250 KIAA16 GAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVV :::::::::::::::.:::::::::::::::.:.:.:.:: :::::::.::::::::.:: gi|564 GAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRVQIVVSLQSRDRIGTGGQVV 90 100 110 120 130 140 260 270 280 KIAA16 DCRGLLENE------------GTVY-------------------EDSGPGRPLSCFMEEP :: :..:. : . : :.::::::::..: gi|564 DCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDEN 150 160 170 180 190 200 290 300 310 320 330 340 KIAA16 APYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEG .: : ..::. : :.: :: .:.:. :. . .: : : :.:::: gi|564 TPITGTNGATCG---------HSSDPRLAERRVRSQRHRNYM----SRTHLHTPPDLPEG 210 220 230 240 250 350 360 370 380 390 400 KIAA16 YEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNS :::::: ::::::::::::::::::::.: :::.. gi|564 YEQRTTQQGQVYFLHTQTGVSTWHDPRVP--------------------------RDLSN 260 270 280 290 410 420 430 440 450 KIAA16 VNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----HHIMNHQCQLKEPSQP .::.::::::::::.:.:..::.::::::::::::::::: : ..:.: :::. .: gi|564 INCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQ 300 310 320 330 340 350 460 470 480 490 500 510 KIAA16 LPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQ .: . . : : . ::.::::::::.::.::: :::::::::::::::::::::::: gi|564 QVVPLCPD-DTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQ 360 370 380 390 400 520 530 540 550 560 570 KIAA16 IMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQI .:::::::: ::::.::::::::::::::::::::: :::::::::::::: :.:: ::: gi|564 VMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQI 410 420 430 440 450 460 580 590 600 610 620 630 KIAA16 NPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPEL ::::..::.:::::::::::::.::::::::.::::.::::::::: : :.:.: :::.: gi|564 NPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDL 470 480 490 500 510 520 640 650 660 670 680 690 KIAA16 HKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWR :.::::::::::: ::::::::::::.:.:.::::::::...:::::::::::::::::: gi|564 HNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWR 530 540 550 560 570 580 700 710 720 730 740 750 KIAA16 FMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVAD :.::::::::::::::::.::::::: ::.::::::: :: :::..::: :::::::. : gi|564 FLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPD 590 600 610 620 630 640 760 770 780 790 800 810 KIAA16 SNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDAN ::.:.:::.::: ::::::::::::::::.:::::::::::: :::::::::: ::: gi|564 SNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQG---AAGPRLFTIHQIDAC 650 660 670 680 690 700 820 830 840 850 KIAA16 TDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE :.::::::::::::::::::::::::::::::.::::::::: gi|564 TNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 710 720 730 740 859 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Thu Mar 5 06:51:43 2009 done: Thu Mar 5 06:55:19 2009 Total Scan time: 1606.070 Total Display time: 0.490 Function used was FASTA [version 34.26.5 April 26, 2007]