# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/fj14026s1.fasta.nr -Q ../query/KIAA1545.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1545, 968 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7809235 sequences Expectation_n fit: rho(ln(x))= 6.9904+/-0.000213; mu= 6.7023+/- 0.012 mean_var=157.5587+/-30.487, 0's: 29 Z-trim: 68 B-trim: 459 in 1/66 Lambda= 0.102177 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 39, opt: 27, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|172045935|sp|Q9HCM7.3|AUT2L_HUMAN RecName: Full ( 972) 6780 1012.0 0 gi|217416343|ref|NP_001136113.1| AUTS2-like protei (1045) 6780 1012.1 0 gi|29468246|gb|AAO85466.1| XTP9 [Homo sapiens] ( 667) 4721 708.4 2.9e-201 gi|194674598|ref|XP_001253535.2| PREDICTED: simila ( 549) 1538 239.1 4.5e-60 gi|126323919|ref|XP_001378040.1| PREDICTED: simila (1025) 1532 238.5 1.3e-59 gi|148688073|gb|EDL20020.1| RIKEN cDNA 2410025L10, ( 574) 1514 235.6 5.3e-59 gi|47124445|gb|AAH69994.1| 2410025L10Rik protein [ ( 476) 1511 235.0 6.3e-59 gi|148688074|gb|EDL20021.1| RIKEN cDNA 2410025L10, (1012) 1514 235.8 8e-59 gi|217416345|ref|NP_001136114.1| AUTS2-like protei (1031) 1514 235.8 8.1e-59 gi|109496207|ref|XP_222254.4| PREDICTED: similar t (1379) 1514 235.9 1e-58 gi|149063720|gb|EDM14043.1| rCG21227, isoform CRA_ ( 916) 1471 229.4 6e-57 gi|148688072|gb|EDL20019.1| RIKEN cDNA 2410025L10, ( 988) 1430 223.4 4.2e-55 gi|125347476|ref|NP_082872.2| AUTS2-like protein i ( 593) 1392 217.6 1.4e-53 gi|26327773|dbj|BAC27627.1| unnamed protein produc ( 603) 1390 217.3 1.8e-53 gi|149063721|gb|EDM14044.1| rCG21227, isoform CRA_ ( 892) 1388 217.2 2.9e-53 gi|73994943|ref|XP_852265.1| PREDICTED: hypothetic (1558) 1387 217.3 4.7e-53 gi|109497563|ref|XP_001080689.1| PREDICTED: simila ( 576) 1320 207.0 2.2e-50 gi|149581454|ref|XP_001521595.1| PREDICTED: simila (1002) 1273 200.3 3.9e-48 gi|118098411|ref|XP_415087.2| PREDICTED: similar t (1358) 1231 194.2 3.6e-46 gi|119909142|ref|XP_610315.3| PREDICTED: similar t ( 737) 1205 190.1 3.3e-45 gi|27817314|emb|CAD61164.1| novel protein similar ( 994) 955 153.4 5e-34 gi|189524331|ref|XP_684927.3| PREDICTED: similar t (1415) 932 150.1 6.8e-33 gi|194384724|dbj|BAG59522.1| unnamed protein produ ( 711) 838 136.0 6.2e-29 gi|37046711|gb|AAH58110.1| Auts2 protein [Mus musc ( 626) 830 134.8 1.3e-28 gi|47227693|emb|CAG09690.1| unnamed protein produc (1096) 812 132.3 1.2e-27 gi|40555743|gb|AAH64693.1| AUTS2 protein [Homo sap (1235) 781 127.8 3.1e-26 gi|118100039|ref|XP_415729.2| PREDICTED: similar t (1251) 780 127.7 3.5e-26 gi|126314127|ref|XP_001365993.1| PREDICTED: simila (1273) 778 127.4 4.3e-26 gi|189518871|ref|XP_685505.3| PREDICTED: similar t (1011) 772 126.4 6.7e-26 gi|126334662|ref|XP_001371549.1| PREDICTED: simila ( 740) 762 124.8 1.5e-25 gi|194218950|ref|XP_001914821.1| PREDICTED: autism (1158) 764 125.3 1.7e-25 gi|73957669|ref|XP_536837.2| PREDICTED: hypothetic (1014) 760 124.6 2.3e-25 gi|124486586|ref|NP_796021.2| autism susceptibilit (1261) 755 124.0 4.5e-25 gi|109066363|ref|XP_001089340.1| PREDICTED: simila (1066) 753 123.6 4.9e-25 gi|41472654|gb|AAS07468.1| unknown [Homo sapiens] (1011) 750 123.2 6.4e-25 gi|114613850|ref|XP_519135.2| PREDICTED: autism su (1216) 750 123.2 7.3e-25 gi|23396464|sp|Q8WXX7.1|AUTS2_HUMAN RecName: Full= (1259) 750 123.3 7.5e-25 gi|148726446|emb|CAN88581.1| novel protein similar ( 867) 734 120.8 2.9e-24 gi|149063128|gb|EDM13451.1| autism susceptibility ( 513) 720 118.5 8.4e-24 gi|109099593|ref|XP_001117851.1| PREDICTED: simila ( 99) 703 115.3 1.5e-23 gi|114662074|ref|XP_001144050.1| PREDICTED: hypoth (1196) 715 118.1 2.6e-23 gi|148687511|gb|EDL19458.1| mCG121910, isoform CRA (1068) 705 116.6 6.6e-23 gi|119628300|gb|EAX07895.1| autism susceptibility ( 801) 679 112.6 7.7e-22 gi|47213395|emb|CAF92390.1| unnamed protein produc ( 936) 654 109.0 1.1e-20 gi|73958394|ref|XP_849173.1| PREDICTED: similar to ( 842) 617 103.5 4.5e-19 gi|210098640|gb|EEA46747.1| hypothetical protein B (1075) 605 101.8 1.8e-18 gi|109128247|ref|XP_001101824.1| PREDICTED: simila ( 609) 600 100.9 2e-18 gi|148687509|gb|EDL19456.1| mCG121910, isoform CRA ( 811) 595 100.2 4.1e-18 gi|148685596|gb|EDL17543.1| mCG142079, isoform CRA ( 448) 581 97.9 1.1e-17 gi|148685598|gb|EDL17545.1| mCG142079, isoform CRA ( 466) 581 97.9 1.2e-17 >>gi|172045935|sp|Q9HCM7.3|AUT2L_HUMAN RecName: Full=AUT (972 aa) initn: 6780 init1: 6780 opt: 6780 Z-score: 5407.8 bits: 1012.0 E(): 0 Smith-Waterman score: 6780; 99.897% identity (100.000% similar) in 968 aa overlap (1-968:5-972) 10 20 30 40 50 KIAA15 EEEVIDGFAIASFSTLEALEKDMALKPHERKEKWERRLIKKPRESETCPPAEPSEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 MEAKEEEVIDGFAIASFSTLEALEKDMALKPHERKEKWERRLIKKPRESETCPPAEPSEN 10 20 30 40 50 60 60 70 80 90 100 110 KIAA15 RRPLEAGSPGQDLEPACDGARKVPLQPSKQMKVTVSKGGDRDSDDDSVLEATSSRDPLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 RRPLEAGSPGQDLEPACDGARKVPLQPSKQMKVTVSKGGDRDSDDDSVLEATSSRDPLSD 70 80 90 100 110 120 120 130 140 150 160 170 KIAA15 SSAHAVSGRGYSCDSESGPDDKASVGSEKLFAPGTDKGPALEKSEAKAGPVPKVSGLERS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 SSAHAVSGRGYSCDSESGPDDKASVGSEKLFAPGTDKGPALEKSEAKAGPVPKVSGLERS 130 140 150 160 170 180 180 190 200 210 220 230 KIAA15 RELSAESFLPTASPAPHAAPCPGPPPGSRANPLVKKEPPAPHRHTPQPPPPQPRGLLPTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 RELSAESFLPTASPAPHAAPCPGPPPGSRANPLVKKEPPAPHRHTPQPPPPQPRGLLPTH 190 200 210 220 230 240 240 250 260 270 280 290 KIAA15 VPASLGAFAGHSQAAANGLHGLSRSSSAPLGLGKHVSLSPHGPGPHLSTSHLALRSQAQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 VPASLGAFAGHSQAAANGLHGLSRSSSAPLGLGKHVSLSPHGPGPHLSTSHLALRSQAQH 250 260 270 280 290 300 300 310 320 330 340 350 KIAA15 QLHAAMFAAPPTLPPPPALPASSLVLPGHPADHELLRQELNTRFLVQSAERPGASLGPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 QLHAAMFAAPPTLPPPPALPASSLVLPGHPADHELLRQELNTRFLVQSAERPGASLGPGA 310 320 330 340 350 360 360 370 380 390 400 410 KIAA15 LLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGLPPTPPAAPPPFDKYAPKLDSPYFRHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 LLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGLPPTPPAAPPPFDKYAPKLDSPYFRHS 370 380 390 400 410 420 420 430 440 450 460 470 KIAA15 SVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 SVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLV 430 440 450 460 470 480 480 490 500 510 520 530 KIAA15 PPGRPRGARDSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAWQIYRHQQKIKEMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 PPGRPRGARDSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAWQIYRHQQKIKEMQ 490 500 510 520 530 540 540 550 560 570 580 590 KIAA15 LDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPASNPFGPSAHPGSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 LDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPASNPFGPSAHPGSF 550 560 570 580 590 600 600 610 620 630 640 650 KIAA15 LPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 LPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAW 610 620 630 640 650 660 660 670 680 690 700 710 KIAA15 NRLHRAPPSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 NRLHRAPPSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPAT 670 680 690 700 710 720 720 730 740 750 760 770 KIAA15 PAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKESRSPAKEEVAKMPARASPPHSKAAPG ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: gi|172 PAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKESRSPAKEEAAKMPARASPPHSKAAPG 730 740 750 760 770 780 780 790 800 810 820 830 KIAA15 DVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERLGAPGFAWEPFRGLELPRRAFPAAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 DVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERLGAPGFAWEPFRGLELPRRAFPAAAP 790 800 810 820 830 840 840 850 860 870 880 890 KIAA15 APGSAALLEPPERPYRDREPHGYSPERLRGELERARAPHLPPAAPALDGALLPSLGALHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 APGSAALLEPPERPYRDREPHGYSPERLRGELERARAPHLPPAAPALDGALLPSLGALHF 850 860 870 880 890 900 900 910 920 930 940 950 KIAA15 PRLSPAALHNGLLARTPPAAAALGAPPPLVTAAGPPTPPGPPRSRTTPLGGLGPGEARDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 PRLSPAALHNGLLARTPPAAAALGAPPPLVTAAGPPTPPGPPRSRTTPLGGLGPGEARDY 910 920 930 940 950 960 960 KIAA15 SPSRNPPEVEAR :::::::::::: gi|172 SPSRNPPEVEAR 970 >>gi|217416343|ref|NP_001136113.1| AUTS2-like protein [H (1045 aa) initn: 6780 init1: 6780 opt: 6780 Z-score: 5407.4 bits: 1012.1 E(): 0 Smith-Waterman score: 6780; 99.897% identity (100.000% similar) in 968 aa overlap (1-968:78-1045) 10 20 30 KIAA15 EEEVIDGFAIASFSTLEALEKDMALKPHER :::::::::::::::::::::::::::::: gi|217 GLRGAPPRGAAPAPRTARPPRRRRRESSSQEEEVIDGFAIASFSTLEALEKDMALKPHER 50 60 70 80 90 100 40 50 60 70 80 90 KIAA15 KEKWERRLIKKPRESETCPPAEPSENRRPLEAGSPGQDLEPACDGARKVPLQPSKQMKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 KEKWERRLIKKPRESETCPPAEPSENRRPLEAGSPGQDLEPACDGARKVPLQPSKQMKVT 110 120 130 140 150 160 100 110 120 130 140 150 KIAA15 VSKGGDRDSDDDSVLEATSSRDPLSDSSAHAVSGRGYSCDSESGPDDKASVGSEKLFAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 VSKGGDRDSDDDSVLEATSSRDPLSDSSAHAVSGRGYSCDSESGPDDKASVGSEKLFAPG 170 180 190 200 210 220 160 170 180 190 200 210 KIAA15 TDKGPALEKSEAKAGPVPKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPGSRANPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 TDKGPALEKSEAKAGPVPKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPGSRANPLV 230 240 250 260 270 280 220 230 240 250 260 270 KIAA15 KKEPPAPHRHTPQPPPPQPRGLLPTHVPASLGAFAGHSQAAANGLHGLSRSSSAPLGLGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 KKEPPAPHRHTPQPPPPQPRGLLPTHVPASLGAFAGHSQAAANGLHGLSRSSSAPLGLGK 290 300 310 320 330 340 280 290 300 310 320 330 KIAA15 HVSLSPHGPGPHLSTSHLALRSQAQHQLHAAMFAAPPTLPPPPALPASSLVLPGHPADHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 HVSLSPHGPGPHLSTSHLALRSQAQHQLHAAMFAAPPTLPPPPALPASSLVLPGHPADHE 350 360 370 380 390 400 340 350 360 370 380 390 KIAA15 LLRQELNTRFLVQSAERPGASLGPGALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 LLRQELNTRFLVQSAERPGASLGPGALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGL 410 420 430 440 450 460 400 410 420 430 440 450 KIAA15 PPTPPAAPPPFDKYAPKLDSPYFRHSSVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 PPTPPAAPPPFDKYAPKLDSPYFRHSSVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQP 470 480 490 500 510 520 460 470 480 490 500 510 KIAA15 KVSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGARDSRSLQKTWVGVAPAPLSASILSQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 KVSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGARDSRSLQKTWVGVAPAPLSASILSQK 530 540 550 560 570 580 520 530 540 550 560 570 KIAA15 PGRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 PGRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLA 590 600 610 620 630 640 580 590 600 610 620 630 KIAA15 RPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 RPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHA 650 660 670 680 690 700 640 650 660 670 680 690 KIAA15 LAPGGSIFAPKEGSSVHGLPSPHEAWNRLHRAPPSFPAPPPWPKSVDAERVSALTNHDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 LAPGGSIFAPKEGSSVHGLPSPHEAWNRLHRAPPSFPAPPPWPKSVDAERVSALTNHDRE 710 720 730 740 750 760 700 710 720 730 740 750 KIAA15 PDNGKEEQERDLLEKTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 PDNGKEEQERDLLEKTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKE 770 780 790 800 810 820 760 770 780 790 800 810 KIAA15 SRSPAKEEVAKMPARASPPHSKAAPGDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRER ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 SRSPAKEEAAKMPARASPPHSKAAPGDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRER 830 840 850 860 870 880 820 830 840 850 860 870 KIAA15 LGAPGFAWEPFRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERLRGELER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 LGAPGFAWEPFRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERLRGELER 890 900 910 920 930 940 880 890 900 910 920 930 KIAA15 ARAPHLPPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPPLVTAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|217 ARAPHLPPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPPLVTAAG 950 960 970 980 990 1000 940 950 960 KIAA15 PPTPPGPPRSRTTPLGGLGPGEARDYSPSRNPPEVEAR :::::::::::::::::::::::::::::::::::::: gi|217 PPTPPGPPRSRTTPLGGLGPGEARDYSPSRNPPEVEAR 1010 1020 1030 1040 >>gi|29468246|gb|AAO85466.1| XTP9 [Homo sapiens] gi| (667 aa) initn: 4721 init1: 4721 opt: 4721 Z-score: 3769.5 bits: 708.4 E(): 2.9e-201 Smith-Waterman score: 4721; 99.850% identity (100.000% similar) in 667 aa overlap (302-968:1-667) 280 290 300 310 320 330 KIAA15 VSLSPHGPGPHLSTSHLALRSQAQHQLHAAMFAAPPTLPPPPALPASSLVLPGHPADHEL :::::::::::::::::::::::::::::: gi|294 MFAAPPTLPPPPALPASSLVLPGHPADHEL 10 20 30 340 350 360 370 380 390 KIAA15 LRQELNTRFLVQSAERPGASLGPGALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|294 LRQELNTRFLVQSAERPGASLGPGALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGLP 40 50 60 70 80 90 400 410 420 430 440 450 KIAA15 PTPPAAPPPFDKYAPKLDSPYFRHSSVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|294 PTPPAAPPPFDKYAPKLDSPYFRHSSVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQPK 100 110 120 130 140 150 460 470 480 490 500 510 KIAA15 VSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGARDSRSLQKTWVGVAPAPLSASILSQKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|294 VSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGARDSRSLQKTWVGVAPAPLSASILSQKP 160 170 180 190 200 210 520 530 540 550 560 570 KIAA15 GRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|294 GRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLAR 220 230 240 250 260 270 580 590 600 610 620 630 KIAA15 PLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|294 PLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHAL 280 290 300 310 320 330 640 650 660 670 680 690 KIAA15 APGGSIFAPKEGSSVHGLPSPHEAWNRLHRAPPSFPAPPPWPKSVDAERVSALTNHDREP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|294 APGGSIFAPKEGSSVHGLPSPHEAWNRLHRAPPSFPAPPPWPKSVDAERVSALTNHDREP 340 350 360 370 380 390 700 710 720 730 740 750 KIAA15 DNGKEEQERDLLEKTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|294 DNGKEEQERDLLEKTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKES 400 410 420 430 440 450 760 770 780 790 800 810 KIAA15 RSPAKEEVAKMPARASPPHSKAAPGDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERL :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: gi|294 RSPAKEEAAKMPARASPPHSKAAPGDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERL 460 470 480 490 500 510 820 830 840 850 860 870 KIAA15 GAPGFAWEPFRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERLRGELERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|294 GAPGFAWEPFRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERLRGELERA 520 530 540 550 560 570 880 890 900 910 920 930 KIAA15 RAPHLPPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPPLVTAAGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|294 RAPHLPPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPPLVTAAGP 580 590 600 610 620 630 940 950 960 KIAA15 PTPPGPPRSRTTPLGGLGPGEARDYSPSRNPPEVEAR ::::::::::::::::::::::::::::::::::::: gi|294 PTPPGPPRSRTTPLGGLGPGEARDYSPSRNPPEVEAR 640 650 660 >>gi|194674598|ref|XP_001253535.2| PREDICTED: similar to (549 aa) initn: 1391 init1: 747 opt: 1538 Z-score: 1234.8 bits: 239.1 E(): 4.5e-60 Smith-Waterman score: 2202; 60.768% identity (72.621% similar) in 599 aa overlap (396-968:32-549) 370 380 390 400 410 420 KIAA15 QHTHQHTHQHTHQHQHTFAPFPAGLPPTPPAAPPPFDKYAPKLDSPYFRHSSVSFFPSFP .::: ::::.::::::::::: . : gi|194 TMGQLYPCGVLSVSVGSMAAVMAADTQVGASAPPMFDKYTPKLDSPYFRHSH-----DCP 10 20 30 40 50 430 440 450 460 470 480 KIAA15 PAIPGLPTLLPHP-GPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGA : : .:. . :.:. . ..... .: gi|194 PC--------SHTQAPLDPCRVLFSPSELPSHSTAIRAFSC------------------- 60 70 80 490 500 510 520 530 540 KIAA15 RDSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEV : :.:. : :. : ..: .:::.:::::::::::::.:::::: :::.::::.: gi|194 RLFRNLRMEDVQVSD-PYRTAI--RKPGKWCAVHVQIAWQIYHHQQKIK-MQLEPHKLDV 90 100 110 120 130 140 550 560 570 580 590 600 KIAA15 GAKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTD :.:::::.:::::::::::::::::::::: :.::.:::.:::::::::::::::: ::: gi|194 GTKLDLFSRPPAPGVFAGFHYPQDLARPLFSSSGATHPAANPFGPSAHPGSFLPTGHLTD 150 160 170 180 190 200 610 620 630 640 650 660 KIAA15 PFSRPSTFGGLGSLSSHAFGGLGSHALAPGG-SIFAPKEGSSVHGLPSPHEAWNRLHRAP :::: :::::::::.:.::::::::::.::: :::::::: ..::::::::::::::::: gi|194 PFSRSSTFGGLGSLGSNAFGGLGSHALTPGGGSIFAPKEGPTLHGLPSPHEAWNRLHRAP 210 220 230 240 250 260 670 680 690 700 710 720 KIAA15 PSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPATPAGHPVS ::::.:::::: .:::::::::::.:: :.::::..::::::::::::::::.:.::: : gi|194 PSFPTPPPWPKPLDAERVSALTNHNRELDKGKEERDRDLLEKTRLLSRASPAAPVGHPGS 270 280 290 300 310 320 730 740 750 760 KIAA15 GLLLRAQSELGRSGAPAEREAEPRVKESRSPAKEE------------------VAKMPAR ::.::.:.. :: : ::::::: :.:::::::.:. ... :.. gi|194 GLVLRGQGDPGRPGIPAEREAELRIKESRSPAREDGPKPSKMALGEGLRLAGLLGREPGK 330 340 350 360 370 380 770 780 790 800 810 820 KIAA15 ASPPHSKAAPGDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERLGAPGFAWEPFRGLE . .. .::::::::::: . :: : :: :::: gi|194 PQEALAEQPQSDVKVKEERGED-GEGPPQPGPGPA------GRER--------------- 390 400 410 420 830 840 850 860 870 880 KIAA15 LPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERLR----GELERARAPHLPPAAP .: :.:::::.:::::: ::::::: ::::::: :: gi|194 --KR--------------LRPPERPFRDREPHDYSPERLREARRDELERARAAHL----- 430 440 450 460 890 900 910 920 930 KIAA15 ALDGA-LLPSLGALHFPRLSPAALHNGLLARTPP-AAAALGAPPPLVTAAGPPTPPGPPR ::: :::.:::::.:::.::::::.::::::: ::::::::::::.:.::::::: :: gi|194 --DGATLLPALGALHYPRLAPAALHNSLLARTPPTAAAALGAPPPLVAAGGPPTPPGQPR 470 480 490 500 510 520 940 950 960 KIAA15 SRTTPLGGLGPGEARDYSPSRNPPEVEAR :::::::. .::::::::::::: ::::: gi|194 SRTTPLGARAPGEARDYSPSRNPQEVEAR 530 540 >>gi|126323919|ref|XP_001378040.1| PREDICTED: similar to (1025 aa) initn: 1920 init1: 725 opt: 1532 Z-score: 1226.6 bits: 238.5 E(): 1.3e-59 Smith-Waterman score: 2413; 45.872% identity (60.694% similar) in 1066 aa overlap (121-968:23-1025) 100 110 120 130 140 KIAA15 VSKGGDRDSDDDSVLEATSSRDPLSDSSAHAVSGRGYSCDSE-SGPDD--KASVGSEKLF : .::... .. : : :... . .. gi|126 MARKGKRMGSSEGRREERWTSLANTGRSWNRAADVRQPGDCGKSQTRRQDVL 10 20 30 40 50 150 160 170 180 190 KIAA15 APGTDKGPAL------EKSEAKAGPVPKVSGLERSRELSAES-FLPT--ASPAPHAAPCP . : . :. :: :::: :::::::::::::... ::: . ::: .: : gi|126 GAGLASDPSSLGFSLSEKPEAKAPIGPKVSGLERSRELSTDTPFLPPVPSPPAPTVATVP 60 70 80 90 100 110 200 210 220 230 240 250 KIAA15 -GPPPGSRANPLVKKEPPAPHRHTPQP----P-PPQPRGLLPTHVPASLGAFAGHSQAAA ::: :....:::::: : : : :::: : :::::. :.:: ::.. :: :. gi|126 LGPPSGTHTSPLVKKEAPPPPRLTPQPQQLQPAPPQPRAPPPAHVGPPLGTYPGHPPATH 120 130 140 150 160 170 260 270 280 290 300 KIAA15 NGLHGL---SRSSSAPLGLGKHVSLSPHGPGP-------HLSTSHLALRSQAQHQLHAA- ::::.: : ::.: :.: :::: :::::: .:.:::.::::::::: ::: gi|126 NGLHSLRSSSASSAASLSLPKHVS--PHGPGPALPLSISNLATSHFALRSQAQHQHHAAA 180 190 200 210 220 230 310 320 330 340 350 360 KIAA15 MFAAPPTLPPPPALPASSLVLPGHPADHELLRQELNTRFLVQSAERPGASLGPGALLRAE ::::::::::::.:::.:::.::::: .: . : ::.. . :.. gi|126 MFAAPPTLPPPPSLPANSLVIPGHPAGEEGAQP----RVLVSDWDLRGVA---------- 240 250 260 270 370 380 390 400 410 KIAA15 FHQHQHTHQHTHQHTHQHQHTFAPFPAGLPPTPPAAPPPFDKYAPKLDSPYFRHSSVS-- : . : : :.::: :. :::::.:::::::::::.:: gi|126 -----SRHLPSGGWTLASQS-----PGGLPF--PGDVRPFDKYGPKLDSPYFRHSNVSAL 280 290 300 310 320 420 KIAA15 -----------------------------------------------------FFPSFPP ::::.:: gi|126 PRVSAAFAPGGCRCRRDSLELEWAETSSTDKGQAFARALVRFSGPRGSCPLGQFFPSYPP 330 340 350 360 370 380 430 440 450 460 470 480 KIAA15 AIPGLPTLLPHPGPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGARD :.::. :: : :::::::::::::.:.: . :.. :: ... gi|126 AMPGMAPLLAHSGPFGSLQGAFQPKTSNP----IDVAS---------------RPSAVHH 390 400 410 420 490 500 510 520 530 540 KIAA15 SRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEVGA . :::: ::. : ... .:::.:::::::::::::.::::::.:.:::::::.:. gi|126 AL-LQKT-PGVSD-PYRTQV--RKPGKWCAVHVQIAWQIYHHQQKIKQMHLDPHKLEIGG 430 440 450 460 470 480 550 560 570 580 590 600 KIAA15 KLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPF :::::.:::::::: ::::::::::::: .::::: ...::::::: .:::::. ::::: gi|126 KLDLFSRPPAPGVFPGFHYPQDLARPLFSTTGAAHATTTPFGPSAHHSSFLPTSHLTDPF 490 500 510 520 530 540 610 620 630 640 650 660 KIAA15 SRPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAWNRLHRAPPSF :: .::.:::.:.:.::::::::::: . :::: ::....... .::: ::::::.:::: gi|126 SRSNTFSGLGNLGSNAFGGLGSHALAHN-SIFAHKEATTLQSFSNPHEPWNRLHRTPPSF 550 560 570 580 590 670 680 690 700 710 720 KIAA15 PAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPAT-PAGHPVSGL :.:: ::: : :: :::.::::.:..::::.:::.:.:.: .:.:::. :. : .:.: gi|126 PTPPQWPKPGDPERSSALSNHDRDPEKGKEERERDILDKSRHSNRSSPASAPVTHQISNL 600 610 620 630 640 650 730 740 750 760 KIAA15 LLRAQSE-----------LGRSGAPAE-REA---EPRVKESRSPAKEEVA--KMPAR--A . :..:. ::. : . :.: : .:::::::.:: .. : : . . gi|126 I-RSNSQTSMEPSRPAAGLGEREPPDRLRDAPLPEHKVKESRSPVKEAASLEKRPPEDAG 660 670 680 690 700 710 770 780 KIAA15 SP------PHSKAA-----------------------PGDVKVKEERGED---------- .: :.::.. .:::::::: :: gi|126 KPVIQSVSPYSKSGLSESLKLSGLVAAKELERNAELLKNDVKVKEERKEDSDVLVVGSEL 720 730 740 750 760 770 790 800 810 KIAA15 --EASEPPA-------------------GGLHP------------APLQLGL----GRER :: :: ::.: : .:. ::: gi|126 SREAPAAPALHGLPLSHSMAAASVPLAMGGVHSLGGVNVLDRSRVMTLLMGMSPLTGREM 780 790 800 810 820 830 820 830 840 850 KIAA15 LGAPGFAWEP--------FRGLELPRR------AFPAAAPAPGSAALLEPPERPYRDREP : :::.::: .:.:.: :: . : : : ... . ::::::::: gi|126 LPHPGFSWEPLRDPLRDPYRSLDLHRRMDLQLRSDPLAHRLPVAGSGFYDHERPYRDREP 840 850 860 870 880 890 860 870 880 890 KIAA15 HGYSPE---------------RLRGELERARAPHLPPAAPALDGAL------LPSLGALH : :.:: .:: ::::::: :: : : .:. : .: :...: gi|126 HDYTPESLLEARREQQERERLQLREELERARAHHLHP--PPIDSHLAHVPPFMPHLSGVH 900 910 920 930 940 950 900 910 920 930 940 950 KIAA15 FPRLSPAA---LHNGLLARTPPAAAALGAPPPLVTAAGPPTPPGPPRSRTTPLGGLGPGE .:::::.: ::::.::::::.:: :.:::::: :.: . :. :: ::::: . .: gi|126 YPRLSPSAATALHNGILARTPPTAA-LSAPPPLVPAGG--ARPASPR-RTTPLTN---SE 960 970 980 990 1000 960 KIAA15 ARDYSPSRNPPEVEAR :::::::::: ::::: gi|126 ARDYSPSRNPKEVEAR 1010 1020 >>gi|148688073|gb|EDL20020.1| RIKEN cDNA 2410025L10, iso (574 aa) initn: 1861 init1: 1348 opt: 1514 Z-score: 1215.4 bits: 235.6 E(): 5.3e-59 Smith-Waterman score: 2126; 58.970% identity (72.425% similar) in 602 aa overlap (398-968:54-574) 370 380 390 400 410 420 KIAA15 THQHTHQHTHQHQHTFAPFPAGLPPTPPAAPPPFDKYAPKLDSPYFRHSSVSFFPSFPPA : :::..:::::::::::..: :. gi|148 ALVTAQPSHGWVLVHWRAFGLYRKSDLRFLPLQFDKFSPKLDSPYFRHSNTS--NSIE-- 30 40 50 60 70 430 440 450 460 470 480 KIAA15 IPGLPTLLPHPGPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGARDS : : . . : : :: : : ::::::..:. gi|148 ITGRSSAV-HT--F--LQKA--PGVSDPYRTAVR-------------------------- 80 90 100 490 500 510 520 530 540 KIAA15 RSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEVGAK :::.:::::::::::::..:::.: :::::::::::.: gi|148 ----------------------KPGKWCAVHVQIAWQIYHQQQKMK-MQLDPHKLEVGTK 110 120 130 140 550 560 570 580 590 600 KIAA15 LDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPFS ::::.::::::.:.::::::::::::: ::::.::..:::::::: ::::::: :::::: gi|148 LDLFSRPPAPGMFSGFHYPQDLARPLFSSTGATHPTANPFGPSAHHGSFLPTGHLTDPFS 150 160 170 180 190 200 610 620 630 640 650 660 KIAA15 RPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAWNRLHRAPPSFP : ::::::::::.:::::::::::.::.::::::::... ::::::.:::::::.::::: gi|148 RSSTFGGLGSLSNHAFGGLGSHALTPGSSIFAPKEGTALLGLPSPHDAWNRLHRVPPSFP 210 220 230 240 250 260 670 680 690 700 710 720 KIAA15 APPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPATPAGHPVSGLLL .:::::: ::.::.:::::::::::.:.::.::::::::::::..::..:.:::.:.:: gi|148 TPPPWPKPVDTERLSALTNHDREPDKGQEEHERDLLEKTRLLSHGSPVAPVGHPISSLLQ 270 280 290 300 310 320 730 740 750 760 770 KIAA15 RAQSELGRSGAPAEREAEPRVKESRSPAKEEVAKMPARASPPHSKAA------------- :...::.: :. .::::: :::::.::.::. ::. :: :. ::: gi|148 RGSGELSRPGVLTEREAETRVKESHSPSKEDGAKLAARPPSPYCKAALGDCLRLAGLLGR 330 340 350 360 370 380 780 790 800 810 820 KIAA15 ------P----GDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERLGAPGFAWEP---- : ::::::::: :::. . . ..: . ..::: . ::.:.: gi|148 ESGKQTPDRPQGDVKVKEERREDETPDLTGVSVHSTATHMGLG-----TAGFVWDPPRDT 390 400 410 420 430 830 840 850 860 870 KIAA15 FRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERL----RGELERARAPHL .::::::::.::: :: : . . : :: ::::::: :::::: : ::::::.: gi|148 YRGLELPRRSFPAPPPAAGPSPF-ELSERAYRDREPHDYSPERLQEVRREELERARVPDS 440 450 460 470 480 490 880 890 900 910 920 930 KIAA15 PPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPPLVTAAGPPTPPG :: ::: :.:.:::.:.:::..::::::::::.::::::::::.: ::::. gi|148 DAAA------LLP---AVHYPRLAPGALHGALLARTPPAAAVLGAPPPLVTAGGVPTPPA 500 510 520 530 540 940 950 960 KIAA15 PPRSRTTPLGGLGPGEARDYSPSRNPPEVEAR ::. :::::::.:::. :::::::: gi|148 HPRTT------LGPGEAREYSPACNPPEVEAR 550 560 570 >>gi|47124445|gb|AAH69994.1| 2410025L10Rik protein [Mus (476 aa) initn: 1800 init1: 1348 opt: 1511 Z-score: 1214.1 bits: 235.0 E(): 6.3e-59 Smith-Waterman score: 2093; 65.784% identity (80.448% similar) in 491 aa overlap (509-968:8-476) 480 490 500 510 520 530 KIAA15 GRPRGARDSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAWQIYRHQQKIKEMQLD .:::.:::::::::::::..:::.: :::: gi|471 DPYRTAVRKPGKWCAVHVQIAWQIYHQQQKMK-MQLD 10 20 30 540 550 560 570 580 590 KIAA15 PHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPASNPFGPSAHPGSFLP :::::::.:::::.::::::.:.::::::::::::: ::::.::..:::::::: ::::: gi|471 PHKLEVGTKLDLFSRPPAPGMFSGFHYPQDLARPLFSSTGATHPTANPFGPSAHHGSFLP 40 50 60 70 80 90 600 610 620 630 640 650 KIAA15 TGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAWNR :: ::::::: ::::::::::.:::::::::::.::.::::::::... ::::::.:::: gi|471 TGHLTDPFSRSSTFGGLGSLSNHAFGGLGSHALTPGSSIFAPKEGTALLGLPSPHDAWNR 100 110 120 130 140 150 660 670 680 690 700 710 KIAA15 LHRAPPSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPATPA :::.:::::.:::::: ::.::.:::::::::::.:.::.::::::::::::..::..:. gi|471 LHRVPPSFPTPPPWPKPVDTERLSALTNHDREPDKGQEEHERDLLEKTRLLSHGSPVAPV 160 170 180 190 200 210 720 730 740 750 760 770 KIAA15 GHPVSGLLLRAQSELGRSGAPAEREAEPRVKESRSPAKEEVAKMPARASPPHSKAA---- :::.:.:: :...::.: :. .::::: :::::.::.::. ::. :: :. ::: gi|471 GHPISSLLQRGSGELSRPGVLTEREAETRVKESHSPSKEDGAKLAARPPSPYCKAALGDC 220 230 240 250 260 270 780 790 800 810 KIAA15 ---------------P----GDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERLGAPG : ::::::::: :::. . . ..: . ..::: . : gi|471 LRLAGLLGRESGKQTPDRPQGDVKVKEERREDETPDLTGVSVHSTATHMGLG-----TAG 280 290 300 310 320 330 820 830 840 850 860 KIAA15 FAWEP----FRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERL----RGE :.:.: .::::::::.::: :: : . . : :: ::::::: :::::: : : gi|471 FVWDPPRDTYRGLELPRRSFPAPPPAAGPSPF-ELSERAYRDREPHDYSPERLQEVRREE 340 350 360 370 380 390 870 880 890 900 910 920 KIAA15 LERARAPHLPPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPPLVT :::::.: :: ::: :.:.:::.:.:::..::::::::::.::::::::: gi|471 LERARVPDSDAAA------LLP---AVHYPRLAPGALHGALLARTPPAAAVLGAPPPLVT 400 410 420 430 440 930 940 950 960 KIAA15 AAGPPTPPGPPRSRTTPLGGLGPGEARDYSPSRNPPEVEAR :.: ::::. ::. :::::::.:::. :::::::: gi|471 AGGVPTPPAHPRTT------LGPGEAREYSPACNPPEVEAR 450 460 470 >>gi|148688074|gb|EDL20021.1| RIKEN cDNA 2410025L10, iso (1012 aa) initn: 2772 init1: 1348 opt: 1514 Z-score: 1212.3 bits: 235.8 E(): 8e-59 Smith-Waterman score: 4215; 66.895% identity (78.711% similar) in 1024 aa overlap (1-968:77-1012) 10 20 30 KIAA15 EEEVIDGFAIASFSTLEALEKDMALKPHER :::::::::::::::::::::::::::::: gi|148 AGLHGAPPQRPTPLRAARPPRRRRRESSSQEEEVIDGFAIASFSTLEALEKDMALKPHER 50 60 70 80 90 100 40 50 60 70 80 KIAA15 KEKWERRLIKKPRESETCPPAEPSENRRPLEAGSPGQDLEPACD-GARKVPLQPSKQMKV ::::..::.:::::::.:: :: ::::.:::.:::::: ::.:: :.::::::::::::: gi|148 KEKWDQRLVKKPRESENCPSAELSENRQPLEVGSPGQDAEPSCDEGTRKVPLQPSKQMKV 110 120 130 140 150 160 90 100 110 120 130 140 KIAA15 TVSKGGDRDSDDDSVLEATSS-----RDPLSDSSAHAVSGRGYSCDSESGPDDKASVGSE :...::::.:::::::::.:: :. ::::::.:::::::::::::: ::::::::: gi|148 TMARGGDRNSDDDSVLEASSSQRSSSREQLSDSSAQAVSGRGYSCDSESGVDDKASVGSE 170 180 190 200 210 220 150 160 170 180 190 200 KIAA15 KLFAPGTDKGPAL-EKSEAKAGPVPKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPG :::::. ::: . :::::::: :::::::::: :::.:.:::...::: :: :: gi|148 KLFAPAPDKGSGRGEKSEAKAGAVPKVSGLERSSELSTEAFLPATAPAPS-----GPAPG 230 240 250 260 270 280 210 220 230 240 250 KIAA15 SRANPLVKKEPPA-PHRHTPQPP-PPQPRGLLPTHVPASLGAFAGHS----QAAANGLH- . :.::::.: :. :: :.::: :: :: :::::: :::::.: . :.:...:: gi|148 TPASPLVKREAPVVPH-HVPQPQLTPQHRGSLPTHVPLSLGAFVGPGPGPGQVASSSLHL 290 300 310 320 330 340 260 270 280 290 300 310 KIAA15 -GLSRSSSA----PLGLGKHVSLSPHGPGPHLSTSHLALRSQAQHQLHAA-MFAAPPTLP .::::::. ::::.:::.:::::::::::::::::::::::: ::: ::::::::: gi|148 HSLSRSSSTVSGTPLGLAKHVTLSPHGPGPHLSTSHLALRSQAQHQHHAAAMFAAPPTLP 350 360 370 380 390 400 320 330 340 350 360 KIAA15 PPPALPASSLVLPGHPADHELLRQELNTRFLVQSAERPGASLGPGALLRAEFHQH--QHT :::::::::::.:::::::::::::::::::::.::::::::::::::::::::: ::: gi|148 PPPALPASSLVIPGHPADHELLRQELNTRFLVQNAERPGASLGPGALLRAEFHQHTHQHT 410 420 430 440 450 460 370 380 390 400 410 420 KIAA15 HQHTHQHTHQHQHTFAPFPAGLPPTP---PAAPPPFDKYAPKLDSPYFRHSSVSFFPSFP :::::::::::::::::: ::::::: :.:: ::::..:::::::::::..: :. gi|148 HQHTHQHTHQHQHTFAPF-AGLPPTPLMPPTAPSPFDKFSPKLDSPYFRHSNTS--NSIE 470 480 490 500 510 430 440 450 460 470 480 KIAA15 PAIPGLPTLLPHPGPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGAR : : . . : : :: : : ::::::..:. gi|148 --ITGRSSAV-HT--F--LQKA--PGVSDPYRTAVR------------------------ 520 530 540 490 500 510 520 530 540 KIAA15 DSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEVG :::.:::::::::::::..:::.: ::::::::::: gi|148 ------------------------KPGKWCAVHVQIAWQIYHQQQKMK-MQLDPHKLEVG 550 560 570 550 560 570 580 590 600 KIAA15 AKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDP .:::::.::::::.:.::::::::::::: ::::.::..:::::::: ::::::: :::: gi|148 TKLDLFSRPPAPGMFSGFHYPQDLARPLFSSTGATHPTANPFGPSAHHGSFLPTGHLTDP 580 590 600 610 620 630 610 620 630 640 650 660 KIAA15 FSRPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAWNRLHRAPPS ::: ::::::::::.:::::::::::.::.::::::::... ::::::.:::::::.::: gi|148 FSRSSTFGGLGSLSNHAFGGLGSHALTPGSSIFAPKEGTALLGLPSPHDAWNRLHRVPPS 640 650 660 670 680 690 670 680 690 700 710 720 KIAA15 FPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPATPAGHPVSGL ::.:::::: ::.::.:::::::::::.:.::.::::::::::::..::..:.:::.:.: gi|148 FPTPPPWPKPVDTERLSALTNHDREPDKGQEEHERDLLEKTRLLSHGSPVAPVGHPISSL 700 710 720 730 740 750 730 740 750 760 770 KIAA15 LLRAQSELGRSGAPAEREAEPRVKESRSPAKEEVAKMPARASPPHSKAA----------- : :...::.: :. .::::: :::::.::.::. ::. :: :. ::: gi|148 LQRGSGELSRPGVLTEREAETRVKESHSPSKEDGAKLAARPPSPYCKAALGDCLRLAGLL 760 770 780 790 800 810 780 790 800 810 820 KIAA15 --------P----GDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERLGAPGFAWEP-- : ::::::::: :::. . . ..: . ..::: . ::.:.: gi|148 GRESGKQTPDRPQGDVKVKEERREDETPDLTGVSVHSTATHMGLG-----TAGFVWDPPR 820 830 840 850 860 870 830 840 850 860 870 KIAA15 --FRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERL----RGELERARAP .::::::::.::: :: : . . : :: ::::::: :::::: : ::::::.: gi|148 DTYRGLELPRRSFPAPPPAAGPSPF-ELSERAYRDREPHDYSPERLQEVRREELERARVP 880 890 900 910 920 930 880 890 900 910 920 930 KIAA15 HLPPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPPLVTAAGPPTP :: ::: :.:.:::.:.:::..::::::::::.::::::::::.: ::: gi|148 DSDAAA------LLP---AVHYPRLAPGALHGALLARTPPAAAVLGAPPPLVTAGGVPTP 940 950 960 970 980 940 950 960 KIAA15 PGPPRSRTTPLGGLGPGEARDYSPSRNPPEVEAR :. ::. :::::::.:::. :::::::: gi|148 PAHPRTT------LGPGEAREYSPACNPPEVEAR 990 1000 1010 >>gi|217416345|ref|NP_001136114.1| AUTS2-like protein is (1031 aa) initn: 2891 init1: 1348 opt: 1514 Z-score: 1212.2 bits: 235.8 E(): 8.1e-59 Smith-Waterman score: 4142; 65.359% identity (76.938% similar) in 1045 aa overlap (1-968:77-1031) 10 20 30 KIAA15 EEEVIDGFAIASFSTLEALEKDMALKPHER :::::::::::::::::::::::::::::: gi|217 AGLHGAPPQRPTPLRAARPPRRRRRESSSQEEEVIDGFAIASFSTLEALEKDMALKPHER 50 60 70 80 90 100 40 50 60 70 80 KIAA15 KEKWERRLIKKPRESETCPPAEPSENRRPLEAGSPGQDLEPACD-GARKVPLQPSKQMKV ::::..::.:::::::.:: :: ::::.:::.:::::: ::.:: :.::::::::::::: gi|217 KEKWDQRLVKKPRESENCPSAELSENRQPLEVGSPGQDAEPSCDEGTRKVPLQPSKQMKV 110 120 130 140 150 160 90 100 110 120 130 140 KIAA15 TVSKGGDRDSDDDSVLEATSS-----RDPLSDSSAHAVSGRGYSCDSESGPDDKASVGSE :...::::.:::::::::.:: :. ::::::.:::::::::::::: ::::::::: gi|217 TMARGGDRNSDDDSVLEASSSQRSSSREQLSDSSAQAVSGRGYSCDSESGVDDKASVGSE 170 180 190 200 210 220 150 160 170 180 190 200 KIAA15 KLFAPGTDKGPAL-EKSEAKAGPVPKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPG :::::. ::: . :::::::: :::::::::: :::.:.:::...::: :: :: gi|217 KLFAPAPDKGSGRGEKSEAKAGAVPKVSGLERSSELSTEAFLPATAPAPS-----GPAPG 230 240 250 260 270 280 210 220 230 240 250 KIAA15 SRANPLVKKEPPA-PHRHTPQPP-PPQPRGLLPTHVPASLGAFAGHS----QAAANGLH- . :.::::.: :. :: :.::: :: :: :::::: :::::.: . :.:...:: gi|217 TPASPLVKREAPVVPH-HVPQPQLTPQHRGSLPTHVPLSLGAFVGPGPGPGQVASSSLHL 290 300 310 320 330 340 260 270 280 290 300 310 KIAA15 -GLSRSSSA----PLGLGKHVSLSPHGPGPHLSTSHLALRSQAQHQLHAA-MFAAPPTLP .::::::. ::::.:::.:::::::::::::::::::::::: ::: ::::::::: gi|217 HSLSRSSSTVSGTPLGLAKHVTLSPHGPGPHLSTSHLALRSQAQHQHHAAAMFAAPPTLP 350 360 370 380 390 400 320 330 340 KIAA15 PPPALPASSLVLPGHPAD-----------------------HELLRQELNTRFLVQSAER :::::::::::.:::::: :::::::::::::::.::: gi|217 PPPALPASSLVIPGHPADASLLISFNQPIMYCQPHSGILIDHELLRQELNTRFLVQNAER 410 420 430 440 450 460 350 360 370 380 390 400 KIAA15 PGASLGPGALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGLPPTP---PAAPPPFDKY :::::::::::::::::: ::::::::::::::::::: ::::::: :.:: ::::. gi|217 PGASLGPGALLRAEFHQH--THQHTHQHTHQHQHTFAPF-AGLPPTPLMPPTAPSPFDKF 470 480 490 500 510 410 420 430 440 450 460 KIAA15 APKLDSPYFRHSSVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQPKVSDPYRAVVKVST .:::::::::::..: :. : : . . : : :: : : ::::::..:. gi|217 SPKLDSPYFRHSNTS--NSIE--ITGRSSAV-HT--F--LQKA--PGVSDPYRTAVR--- 520 530 540 550 560 470 480 490 500 510 520 KIAA15 CWEGPWQGRTLVPPGRPRGARDSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAWQ :::.::::::::::: gi|217 ---------------------------------------------KPGKWCAVHVQIAWQ 570 530 540 550 560 570 580 KIAA15 IYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPAS ::..:::.: :::::::::::.:::::.::::::.:.::::::::::::: ::::.::.. gi|217 IYHQQQKMK-MQLDPHKLEVGTKLDLFSRPPAPGMFSGFHYPQDLARPLFSSTGATHPTA 580 590 600 610 620 630 590 600 610 620 630 640 KIAA15 NPFGPSAHPGSFLPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEGS :::::::: ::::::: ::::::: ::::::::::.:::::::::::.::.::::::::. gi|217 NPFGPSAHHGSFLPTGHLTDPFSRSSTFGGLGSLSNHAFGGLGSHALTPGSSIFAPKEGT 640 650 660 670 680 690 650 660 670 680 690 700 KIAA15 SVHGLPSPHEAWNRLHRAPPSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLE .. ::::::.:::::::.:::::.:::::: ::.::.:::::::::::.:.::.:::::: gi|217 ALLGLPSPHDAWNRLHRVPPSFPTPPPWPKPVDTERLSALTNHDREPDKGQEEHERDLLE 700 710 720 730 740 750 710 720 730 740 750 760 KIAA15 KTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKESRSPAKEEVAKMPA ::::::..::..:.:::.:.:: :...::.: :. .::::: :::::.::.::. ::. : gi|217 KTRLLSHGSPVAPVGHPISSLLQRGSGELSRPGVLTEREAETRVKESHSPSKEDGAKLAA 760 770 780 790 800 810 770 780 790 800 KIAA15 RASPPHSKAA-------------------P----GDVKVKEERGEDEASEPPAGGLHPAP : :. ::: : ::::::::: :::. . . ..: . gi|217 RPPSPYCKAALGDCLRLAGLLGRESGKQTPDRPQGDVKVKEERREDETPDLTGVSVHSTA 820 830 840 850 860 870 810 820 830 840 850 KIAA15 LQLGLGRERLGAPGFAWEP----FRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPH ..::: . ::.:.: .::::::::.::: :: : . . : :: ::::::: gi|217 THMGLG-----TAGFVWDPPRDTYRGLELPRRSFPAPPPAAGPSPF-ELSERAYRDREPH 880 890 900 910 920 930 860 870 880 890 900 910 KIAA15 GYSPERL----RGELERARAPHLPPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTP :::::: : ::::::.: :: ::: :.:.:::.:.:::..:::::: gi|217 DYSPERLQEVRREELERARVPDSDAAA------LLP---AVHYPRLAPGALHGALLARTP 940 950 960 970 980 920 930 940 950 960 KIAA15 PAAAALGAPPPLVTAAGPPTPPGPPRSRTTPLGGLGPGEARDYSPSRNPPEVEAR ::::.::::::::::.: ::::. ::. :::::::.:::. :::::::: gi|217 PAAAVLGAPPPLVTAGGVPTPPAHPRTT------LGPGEAREYSPACNPPEVEAR 990 1000 1010 1020 1030 >>gi|109496207|ref|XP_222254.4| PREDICTED: similar to au (1379 aa) initn: 2826 init1: 1320 opt: 1514 Z-score: 1210.6 bits: 235.9 E(): 1e-58 Smith-Waterman score: 3362; 59.259% identity (70.370% similar) in 999 aa overlap (53-968:514-1379) 30 40 50 60 70 KIAA15 MALKPHERKEKWERRLIKKPRESETCPPAEPSENRRPLEAGSPGQDLEP-----ACDG-A :.. :: : : . :. . : : gi|109 PSLLGQPGLAPQPLLRPLCQLRRQSLLGLVPARRPRPSILGHPFRPLRSQWTRHSAPGVA 490 500 510 520 530 540 80 90 100 110 120 130 KIAA15 RKVPLQPSKQMKVTVSKGGDRDSDDDSVLEATSS-----RDPLSDSSAHAVSGRGYSCDS :..: .::::...::::.:::::::::.:: :: ::::::.:::::::: gi|109 RQAP-----SMKVTMARGGDRNSDDDSVLEASSSQHSSSRDQLSDSSAQAVSGRGYS--- 550 560 570 580 590 140 150 160 170 180 190 KIAA15 ESGPDDKASVGSEKLFAPGTDKGPALEKSEAKAGPVPKVSGLERSRELSAESFLPTASPA :::::::::::. ::: :: gi|109 -------ASVGSEKLFAPAPDKG----------------SG------------------- 600 610 200 210 220 230 240 KIAA15 PHAAPCP-GPPPGSRANPLVKKEPP-APHRHTPQPP-PPQPRGLLPTHVPASLGAFAGHS :: : :: ::.::.::::.: : .:: :.::: :: :: :::::: :::::.: . gi|109 --RAPTPSGPLPGARASPLVKREAPIVPH-HVPQPQLTPQHRGSLPTHVPLSLGAFVGPG 620 630 640 650 660 670 250 260 270 280 290 KIAA15 ----QAAANGLHGLS-RSSSA----PLGLGKHVSLSPHGPGPHLSTSHLALRSQAQHQLH :.:.:.:: : ::::. ::::.:::.:::::::::::::::::::::::: : gi|109 PGPGQVASNSLHLHSLRSSSTVSGTPLGLAKHVTLSPHGPGPHLSTSHLALRSQAQHQHH 680 690 700 710 720 730 300 310 320 330 KIAA15 AA-MFAAPPTLPPPPALPASSLVLPGHPAD-----------------------HELLRQE :: ::::::::::::::::::::.::::.: ::::::: gi|109 AAAMFAAPPTLPPPPALPASSLVIPGHPTDASLLISFNQPIMYCQPHSGILIDHELLRQE 740 750 760 770 780 790 340 350 360 370 380 390 KIAA15 LNTRFLVQSAERPGASLGPGALLRAEFHQH--QHTHQHTHQHTHQHQHTFAPFPAGLPPT ::::::::.::::::::::::::::::::: ::::::::::::::::::::: :::::: gi|109 LNTRFLVQNAERPGASLGPGALLRAEFHQHTHQHTHQHTHQHTHQHQHTFAPF-AGLPPT 800 810 820 830 840 400 410 420 430 440 450 KIAA15 P---PAAPPPFDKYAPKLDSPYFRHSSVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQP : :.:: ::::..:::::::::::..: :. : : . . : : :: : : gi|109 PLMPPTAPSPFDKFSPKLDSPYFRHSNTS--NSI--EITGRSSAV-HT--F--LQKA--P 850 860 870 880 890 460 470 480 490 500 510 KIAA15 KVSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGARDSRSLQKTWVGVAPAPLSASILSQK ::::::..:. : gi|109 GVSDPYRTAVR------------------------------------------------K 900 910 520 530 540 550 560 570 KIAA15 PGRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLA ::.:::::::::::::..:::.: :::::::::::.:::::.:::: :.:.::::::::: gi|109 PGKWCAVHVQIAWQIYHQQQKMK-MQLDPHKLEVGTKLDLFSRPPAQGMFSGFHYPQDLA 920 930 940 950 960 580 590 600 610 620 630 KIAA15 RPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHA :::: ::::.::..:::::::: ::::::: ::::::: ::::::::::.:::::::::: gi|109 RPLFSSTGATHPTANPFGPSAHHGSFLPTGHLTDPFSRSSTFGGLGSLSNHAFGGLGSHA 970 980 990 1000 1010 1020 640 650 660 670 680 690 KIAA15 LAPGGSIFAPKEGSSVHGLPSPHEAWNRLHRAPPSFPAPPPWPKSVDAERVSALTNHDRE :.::.::::::::... ::::::.:::::::.:::::.:::::: .:.::.::::::::: gi|109 LTPGSSIFAPKEGTALLGLPSPHDAWNRLHRVPPSFPTPPPWPKPMDTERLSALTNHDRE 1030 1040 1050 1060 1070 1080 700 710 720 730 740 750 KIAA15 PDNGKEEQERDLLEKTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKE ::.:.::.::.:::::::::..:: .:.:::.:.:: : ..::.: :. .::::: :::: gi|109 PDKGQEEHERNLLEKTRLLSHGSPIAPVGHPISSLLQRDSGELSRPGVLTEREAETRVKE 1090 1100 1110 1120 1130 1140 760 770 780 KIAA15 SRSPAKEEVAKMPARASPPHSKAA-------------------P----GDVKVKEERGED ..::.::. ::. :: :. ::: : ::::::::: :: gi|109 NHSPSKEDGAKLAARPPSPYCKAALGDCLRLAGLLGRESGKQTPDRPQGDVKVKEERRED 1150 1160 1170 1180 1190 1200 790 800 810 820 830 840 KIAA15 EASEPPAGGLHPAPLQLGLGRERLGAPGFAWEP----FRGLELPRRAFPAAAPAPGSAAL :. . . ..: . .:: ::. ::.:.: .:::.::::.::: :: : : . gi|109 ETPDLTGVSVHSTATHLG-----LGTSGFVWDPPRDTYRGLDLPRRSFPAPPPAAGPAPF 1210 1220 1230 1240 1250 1260 850 860 870 880 890 KIAA15 LEPPERPYRDREPHGYSPERLRG----ELERARAPHLPPAAPALDGALLPSLGALHFPRL : :: ::::: : ::::::: :::::::: :.:::: :.:.::: gi|109 -ELSERAYRDRESHDYSPERLREVRREELERARAPDS-------DAALLP---AMHYPRL 1270 1280 1290 1300 1310 900 910 920 930 940 950 KIAA15 SPAALHNGLLARTPPAAAALGAPPPLVTAAGPPTPPGPPRSRTTPLGGLGPGEARDYSPS .:.:::..:::::::::::::::::::::.: ::::. :: ::::. :::::::::::. gi|109 APGALHGALLARTPPAAAALGAPPPLVTAGGVPTPPARPR--TTPLA-LGPGEARDYSPA 1320 1330 1340 1350 1360 1370 960 KIAA15 RNPPEVEAR :::::::: gi|109 CNPPEVEAR 968 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Thu Mar 5 01:41:23 2009 done: Thu Mar 5 01:44:49 2009 Total Scan time: 1691.850 Total Display time: 0.610 Function used was FASTA [version 34.26.5 April 26, 2007]