hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080502/iprscan-20080502-03274986/chunk_1/iprscan-20080502-03274986.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA1459 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF07714.7.ls Protein tyrosine kinase 483.0 3.2e-142 1 PF07714.7.fs Protein tyrosine kinase 481.2 1.2e-141 1 PF00069.15.ls Protein kinase domain 150.6 3.9e-42 1 PF00069.15.fs Protein kinase domain 148.7 3.9e-42 1 PF01404.9.fs Ephrin receptor ligand binding domain 125.2 1.6e-36 1 PF00041.11.ls Fibronectin type III domain 120.0 6.1e-33 2 PF00041.11.fs Fibronectin type III domain 116.0 1.1e-32 2 PF00536.20.fs SAM domain (Sterile alpha motif) 92.4 1.4e-26 1 PF00536.20.ls SAM domain (Sterile alpha motif) 94.4 3.3e-25 1 PF07647.7.fs SAM domain (Sterile alpha motif) 63.7 5.1e-18 1 PF07647.7.ls SAM domain (Sterile alpha motif) 58.1 2.7e-14 1 PF01404.9.ls Ephrin receptor ligand binding domain -40.2 1.7e-06 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF01404.9.fs 1/1 1 52 [. 126 177 .] 125.2 1.6e-36 PF01404.9.ls 1/1 1 52 [. 1 177 [] -40.2 1.7e-06 PF00041.11.ls 1/2 177 273 .. 1 84 [] 39.4 1.2e-08 PF00041.11.fs 1/2 177 273 .. 1 84 [] 37.3 4.4e-10 PF00041.11.ls 2/2 285 372 .. 1 84 [] 80.7 4.3e-21 PF00041.11.fs 2/2 285 372 .. 1 84 [] 78.7 6e-22 PF00069.15.ls 1/1 483 740 .. 1 287 [] 150.6 3.9e-42 PF00069.15.fs 1/1 483 740 .. 1 287 [] 148.7 3.9e-42 PF07714.7.fs 1/1 483 740 .. 1 272 [] 481.2 1.2e-141 PF07714.7.ls 1/1 483 740 .. 1 272 [] 483.0 3.2e-142 PF07647.7.ls 1/1 775 842 .. 1 72 [] 58.1 2.7e-14 PF00536.20.fs 1/1 779 840 .. 1 65 [] 92.4 1.4e-26 PF00536.20.ls 1/1 779 840 .. 1 65 [] 94.4 3.3e-25 PF07647.7.fs 1/1 782 842 .. 8 72 .] 63.7 5.1e-18 Alignments of top-scoring domains: PF01404.9.fs: domain 1 of 1, from 1 to 52: score 125.2, E = 1.6e-36 *->SFtqvDlgdrvlKLNtEvRsvGPLsKkGFYLAFQDvGACiALvSVRV SFt +Dlg r+lKLNtEvRsvGPLsK+GFYLAFQD+GAC+A++S+R+ KIAA1459 1 SFTGADLGVRRLKLNTEVRSVGPLSKRGFYLAFQDIGACLAILSLRI 47 FYKKC<-* +YKKC KIAA1459 48 YYKKC 52 PF01404.9.ls: domain 1 of 1, from 1 to 52: score -40.2, E = 1.7e-06 *->EvtLLDtktatgELGWltyPpdGWeEvsglDEnnrpIrTYQVCnVme KIAA1459 - ----------------------------------------------- - pnQnNWLRTnwIeRrgAqRvyveLkFTvRDCnSlPgvlGtCKETFNLYYy KIAA1459 - -------------------------------------------------- - ESDedvgtalpawrenqyiKvDTIAADESFtqvDlgdrvlKLNtEvRsvG SFt +Dlg r+lKLNtEvRsvG KIAA1459 1 ----------------------------SFTGADLGVRRLKLNTEVRSVG 22 PLsKkGFYLAFQDvGACiALvSVRVFYKKC<-* PLsK+GFYLAFQD+GAC+A++S+R++YKKC KIAA1459 23 PLSKRGFYLAFQDIGACLAILSLRIYYKKC 52 PF00041.11.ls: domain 1 of 2, from 177 to 273: score 39.4, E = 1.2e-08 *->PsaPtnltvtdvtstsltlsWspPt..gngpitgYevtyR....... PsaP nl +++v+ ts+tl+W pP ++g++ Y+ +R+ + + KIAA1459 177 PSAPVNL-ISSVNGTSVTLEWAPPLdpGGRSDITYNAVCRrcpwals 222 ..qpkngge.wkeltvpgtttsytltgLkPgteYtvrVqAvnggG..Gpe + + +++g + + ++++ ++ s + +L ++++Y++++ Avng+ + +pe KIAA1459 223 rcEACGSGTrFVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSdlSPE 272 S<-* KIAA1459 273 P 273 PF00041.11.fs: domain 1 of 2, from 177 to 273: score 37.3, E = 4.4e-10 *->PsaPtnltvtdvtstsltlsWspPt..gngpitgYevtyR....... PsaP nl +++v+ ts+tl+W pP ++g++ Y+ +R+ + + KIAA1459 177 PSAPVNL-ISSVNGTSVTLEWAPPLdpGGRSDITYNAVCRrcpwals 222 ..qpkngge.wkeltvpgtttsytltgLkPgteYtvrVqAvnggG..Gpe + + +++g + + ++++ ++ s + +L ++++Y++++ Avng+ + +pe KIAA1459 223 rcEACGSGTrFVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSdlSPE 272 S<-* KIAA1459 273 P 273 PF00041.11.ls: domain 2 of 2, from 285 to 372: score 80.7, E = 4.3e-21 *->PsaPtnltvtdv...tstsltlsWspPt.gngpitgYevtyRqpkng aP+++ v+ +++ + ts++l W+ P+++ng i Ye++y ++k++ KIAA1459 285 QAAPSQVVVIRQeraGQTSVSLLWQEPEqPNGIILEYEIKY-YEKDK 330 gewkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* + t++ +tt++t++gLkPgt+Y+++V+A++ +G G++S KIAA1459 331 EMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGcGRFS 372 PF00041.11.fs: domain 2 of 2, from 285 to 372: score 78.7, E = 6e-22 *->PsaPtnltvtdv...tstsltlsWspPt.gngpitgYevtyRqpkng aP+++ v+ +++ + ts++l W+ P+++ng i Ye++y ++k++ KIAA1459 285 QAAPSQVVVIRQeraGQTSVSLLWQEPEqPNGIILEYEIKY-YEKDK 330 gewkeltvpgtttsytltgLkPgteYtvrVqAvnggG.GpeS<-* + t++ +tt++t++gLkPgt+Y+++V+A++ +G G++S KIAA1459 331 EMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGcGRFS 372 PF00069.15.ls: domain 1 of 1, from 483 to 740: score 150.6, E = 3.9e-42 *->yelleklGsGsfGtVykakhkgtgk...iVAvKiikkrkekskkdkt +++++++GsG +G+V+ ++ + g+++ VA+K +k ++ +++ KIAA1459 483 IHIEKIIGSGDSGEVCYGRLRVPGQrdvPVAIKALKAGYTER--QRR 527 arrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdy ++++ E++i+ ++HpNI+rl +v+++++ +V+Ey+e+G +L ++ KIAA1459 528 DFLS-EASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENG----SLDTF 572 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldn l+ +g + + ++ +++ + g+ YL + g +HRDL N+L+d+ KIAA1459 573 LR--THDGQF--TIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDS 618 ngvvdaflKiaDFGlAkkls..t.sss.lttfvGTpwYmAPEvllggngy n v+ K++DFGl+++l+++ + ++t+ +++ APE + + KIAA1459 619 NLVC----KVSDFGLSRVLEddPdAAYtTTGGKIPIRWTAPEAIA-FRTF 663 gtkvDvWSlGvilyellt.GkpPFsgevqds.ldqlqlirkilgpplefd ++++DvWS+Gv+++e+l G+ P+++ +++d + +++ + p + KIAA1459 664 SSASDVWSFGVVMWEVLAyGERPYWNM---TnRDVISSVEEGYRLPAPMG 710 spewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf< +p ++ +L+ +c++kD ++R+ + +i+ + KIAA1459 711 CP-----------------HALHQLMLDCWHKDRAQRPRFSQIVSV--L 740 -* KIAA1459 - - PF00069.15.fs: domain 1 of 1, from 483 to 740: score 148.7, E = 3.9e-42 *->yelleklGsGsfGtVykakhkgtgk...iVAvKiikkrkekskkdkt +++++++GsG +G+V+ ++ + g+++ VA+K +k ++ +++ KIAA1459 483 IHIEKIIGSGDSGEVCYGRLRVPGQrdvPVAIKALKAGYTER--QRR 527 arrlsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdy ++++ E++i+ ++HpNI+rl +v+++++ +V+Ey+e+G +L ++ KIAA1459 528 DFLS-EASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENG----SLDTF 572 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldn l+ +g + + ++ +++ + g+ YL + g +HRDL N+L+d+ KIAA1459 573 LR--THDGQF--TIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDS 618 ngvvdaflKiaDFGlAkkls..t.sss.lttfvGTpwYmAPEvllggngy n v+ K++DFGl+++l+++ + ++t+ +++ APE + + KIAA1459 619 NLVC----KVSDFGLSRVLEddPdAAYtTTGGKIPIRWTAPEAIA-FRTF 663 gtkvDvWSlGvilyellt.GkpPFsgevqds.ldqlqlirkilgpplefd ++++DvWS+Gv+++e+l G+ P+++ +++d + +++ + p + KIAA1459 664 SSASDVWSFGVVMWEVLAyGERPYWNM---TnRDVISSVEEGYRLPAPMG 710 spewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf< +p ++ +L+ +c++kD ++R+ + +i+ + KIAA1459 711 CP-----------------HALHQLMLDCWHKDRAQRPRFSQIVSV--L 740 -* KIAA1459 - - PF07714.7.fs: domain 1 of 1, from 483 to 740: score 481.2, E = 1.2e-141 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +++ k +G+G GeV+ G+l+ +++ +++VA+K Lk g++e++ KIAA1459 483 IHIEKIIGSGDSGEVCYGRLR-VPGQRDVPVAIKALKA-GYTERQ-- 525 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL r+dFl+EAsiM ++ dHpNi+rL Gv+t+ g+ +iVtEyme+G+L KIAA1459 526 RRDFLSEASIMGQF-DHPNIIRLEGVVTR-GRL----AMIVTEYMENGSL 569 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs ++fLr+h ++++t+ +L+++ + + +GM YL++ ++vHRDLAARN+LV+ KIAA1459 570 DTFLRTH--DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVD 617 enlvVKIsDFGLaRdi..ynddyYvrkkgggklPvkWmAPEslkygkFts +nlv+K+sDFGL+R +++++d Y +++ggk+P++W+APE+++++ F+s KIAA1459 618 SNLVCKVSDFGLSRVLedDPDAAY--TTTGGKIPIRWTAPEAIAFRTFSS 665 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd +SDVWSFGV++WE++ +Ge P Y++m+n +v+ + e+GyRLp+P++CP KIAA1459 666 ASDVWSFGVVMWEVLAYGERP-YWNMTNRDVISSV-EEGYRLPAPMGCPH 713 elYdlMlqCWaedPedRPtFselveeL<-* l++lMl+CW++d ++RP+Fs++v+ L KIAA1459 714 ALHQLMLDCWHKDRAQRPRFSQIVSVL 740 PF07714.7.ls: domain 1 of 1, from 483 to 740: score 483.0, E = 3.2e-142 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie +++ k +G+G GeV+ G+l+ +++ +++VA+K Lk g++e++ KIAA1459 483 IHIEKIIGSGDSGEVCYGRLR-VPGQRDVPVAIKALKA-GYTERQ-- 525 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL r+dFl+EAsiM ++ dHpNi+rL Gv+t+ g+ +iVtEyme+G+L KIAA1459 526 RRDFLSEASIMGQF-DHPNIIRLEGVVTR-GRL----AMIVTEYMENGSL 569 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs ++fLr+h ++++t+ +L+++ + + +GM YL++ ++vHRDLAARN+LV+ KIAA1459 570 DTFLRTH--DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVD 617 enlvVKIsDFGLaRdi..ynddyYvrkkgggklPvkWmAPEslkygkFts +nlv+K+sDFGL+R +++++d Y +++ggk+P++W+APE+++++ F+s KIAA1459 618 SNLVCKVSDFGLSRVLedDPDAAY--TTTGGKIPIRWTAPEAIAFRTFSS 665 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPd +SDVWSFGV++WE++ +Ge P Y++m+n +v+ + e+GyRLp+P++CP KIAA1459 666 ASDVWSFGVVMWEVLAYGERP-YWNMTNRDVISSV-EEGYRLPAPMGCPH 713 elYdlMlqCWaedPedRPtFselveeL<-* l++lMl+CW++d ++RP+Fs++v+ L KIAA1459 714 ALHQLMLDCWHKDRAQRPRFSQIVSVL 740 PF07647.7.ls: domain 1 of 1, from 775 to 842: score 58.1, E = 2.7e-14 *->veswslesvaeWLesiglegqYkdnFsdqgitglellllrlteedLa +v++WL+si++ g+Y+d F + g+++l ++ lr++++d KIAA1459 775 SGGGGGLTVGDWLDSIRM-GRYRDHFAAGGYSSLGMV-LRMNAQDV- 818 klalGitsvghRkkilkkiqelkqq<-* alGit+ gh+kkil +iq ++ q KIAA1459 819 R-ALGITLMGHQKKILGSIQTMRAQ 842 PF00536.20.fs: domain 1 of 1, from 779 to 840: score 92.4, E = 1.4e-26 *->dgwsfesVgeWLesiglgqYidnFlsagyidgdtllqlteeDLedlG +g +Vg+WL+si++g+Y+d+F++ gy+++ ++l++ ++D ++lG KIAA1459 779 GG---LTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRALG 822 vtllGHrkKIlssIqgLk<-* +tl+GH+kKIl sIq+++ KIAA1459 823 ITLMGHQKKILGSIQTMR 840 PF00536.20.ls: domain 1 of 1, from 779 to 840: score 94.4, E = 3.3e-25 *->dgwsfesVgeWLesiglgqYidnFlsagyidgdtllqlteeDLedlG +g +Vg+WL+si++g+Y+d+F++ gy+++ ++l++ ++D ++lG KIAA1459 779 GG---LTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRALG 822 vtllGHrkKIlssIqgLk<-* +tl+GH+kKIl sIq+++ KIAA1459 823 ITLMGHQKKILGSIQTMR 840 PF07647.7.fs: domain 1 of 1, from 782 to 842: score 63.7, E = 5.1e-18 *->svaeWLesiglegqYkdnFsdqgitglellllrlteedLaklalGit +v++WL+si++ g+Y+d F + g+++l ++ lr++++d alGit KIAA1459 782 TVGDWLDSIRM-GRYRDHFAAGGYSSLGMV-LRMNAQDV-R-ALGIT 824 svghRkkilkkiqelkqq<-* + gh+kkil +iq ++ q KIAA1459 825 LMGHQKKILGSIQTMRAQ 842 //